-- dump date 20140619_165238 -- class Genbank::misc_feature -- table misc_feature_note -- id note 446468000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 446468000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468000003 Walker A motif; other site 446468000004 ATP binding site [chemical binding]; other site 446468000005 Walker B motif; other site 446468000006 arginine finger; other site 446468000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 446468000008 DnaA box-binding interface [nucleotide binding]; other site 446468000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 446468000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446468000011 putative DNA binding surface [nucleotide binding]; other site 446468000012 dimer interface [polypeptide binding]; other site 446468000013 beta-clamp/clamp loader binding surface; other site 446468000014 beta-clamp/translesion DNA polymerase binding surface; other site 446468000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446468000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 446468000017 recombination protein F; Reviewed; Region: recF; PRK00064 446468000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 446468000019 Walker A/P-loop; other site 446468000020 ATP binding site [chemical binding]; other site 446468000021 Q-loop/lid; other site 446468000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468000023 ABC transporter signature motif; other site 446468000024 Walker B; other site 446468000025 D-loop; other site 446468000026 H-loop/switch region; other site 446468000027 Protein of unknown function (DUF721); Region: DUF721; pfam05258 446468000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 446468000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468000030 Mg2+ binding site [ion binding]; other site 446468000031 G-X-G motif; other site 446468000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446468000033 anchoring element; other site 446468000034 dimer interface [polypeptide binding]; other site 446468000035 ATP binding site [chemical binding]; other site 446468000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 446468000037 active site 446468000038 putative metal-binding site [ion binding]; other site 446468000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446468000040 DNA gyrase subunit A; Validated; Region: PRK05560 446468000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446468000042 CAP-like domain; other site 446468000043 active site 446468000044 primary dimer interface [polypeptide binding]; other site 446468000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 446468000052 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468000053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468000054 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468000055 von Willebrand factor type A domain; Region: VWA_2; pfam13519 446468000056 metal ion-dependent adhesion site (MIDAS); other site 446468000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468000058 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468000059 putative substrate translocation pore; other site 446468000060 thiamine pyrophosphate protein; Provisional; Region: PRK08273 446468000061 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 446468000062 PYR/PP interface [polypeptide binding]; other site 446468000063 dimer interface [polypeptide binding]; other site 446468000064 tetramer interface [polypeptide binding]; other site 446468000065 TPP binding site [chemical binding]; other site 446468000066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446468000067 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 446468000068 TPP-binding site [chemical binding]; other site 446468000069 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 446468000070 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446468000071 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 446468000072 tetramer interface [polypeptide binding]; other site 446468000073 heme binding pocket [chemical binding]; other site 446468000074 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 446468000075 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468000076 molybdopterin cofactor binding site; other site 446468000077 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468000078 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468000079 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 446468000080 molybdopterin cofactor binding site; other site 446468000081 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 446468000082 4Fe-4S binding domain; Region: Fer4; pfam00037 446468000083 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 446468000084 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 446468000085 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468000086 active site 446468000087 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446468000088 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446468000089 tetramer interface [polypeptide binding]; other site 446468000090 TPP-binding site [chemical binding]; other site 446468000091 heterodimer interface [polypeptide binding]; other site 446468000092 phosphorylation loop region [posttranslational modification] 446468000093 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446468000094 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446468000095 alpha subunit interface [polypeptide binding]; other site 446468000096 TPP binding site [chemical binding]; other site 446468000097 heterodimer interface [polypeptide binding]; other site 446468000098 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468000099 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468000100 E3 interaction surface; other site 446468000101 lipoyl attachment site [posttranslational modification]; other site 446468000102 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446468000103 e3 binding domain; Region: E3_binding; pfam02817 446468000104 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446468000105 hypothetical protein; Provisional; Region: PRK07338 446468000106 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 446468000107 metal binding site [ion binding]; metal-binding site 446468000108 dimer interface [polypeptide binding]; other site 446468000109 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 446468000110 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 446468000111 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468000112 dimerization interface [polypeptide binding]; other site 446468000113 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446468000114 putative DNA binding site [nucleotide binding]; other site 446468000115 putative Zn2+ binding site [ion binding]; other site 446468000116 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468000117 AsnC family; Region: AsnC_trans_reg; pfam01037 446468000118 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 446468000119 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 446468000120 substrate binding site [chemical binding]; other site 446468000121 dimer interface [polypeptide binding]; other site 446468000122 NADP binding site [chemical binding]; other site 446468000123 catalytic residues [active] 446468000124 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446468000125 active site 2 [active] 446468000126 active site 1 [active] 446468000127 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446468000128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468000129 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 446468000130 putative deacylase active site [active] 446468000131 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446468000132 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 446468000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468000134 active site 446468000135 ATP binding site [chemical binding]; other site 446468000136 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468000137 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468000138 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468000139 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 446468000140 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446468000141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468000142 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468000143 NAD(P) binding site [chemical binding]; other site 446468000144 active site 446468000145 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446468000146 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468000147 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446468000148 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446468000149 Walker A/P-loop; other site 446468000150 ATP binding site [chemical binding]; other site 446468000151 Q-loop/lid; other site 446468000152 ABC transporter signature motif; other site 446468000153 Walker B; other site 446468000154 D-loop; other site 446468000155 H-loop/switch region; other site 446468000156 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446468000157 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446468000158 Walker A/P-loop; other site 446468000159 ATP binding site [chemical binding]; other site 446468000160 Q-loop/lid; other site 446468000161 ABC transporter signature motif; other site 446468000162 Walker B; other site 446468000163 D-loop; other site 446468000164 H-loop/switch region; other site 446468000165 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446468000166 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468000167 TM-ABC transporter signature motif; other site 446468000168 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446468000169 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446468000170 TM-ABC transporter signature motif; other site 446468000171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468000172 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446468000173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468000174 NAD(P) binding site [chemical binding]; other site 446468000175 active site 446468000176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468000177 MarR family; Region: MarR_2; cl17246 446468000178 GAF domain; Region: GAF; pfam01590 446468000179 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468000180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468000181 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 446468000182 NAD(P) binding site [chemical binding]; other site 446468000183 active site 446468000184 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 446468000185 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468000186 MarR family; Region: MarR; pfam01047 446468000187 acyl-CoA synthetase; Validated; Region: PRK07788 446468000188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468000189 AMP binding site [chemical binding]; other site 446468000190 active site 446468000191 acyl-activating enzyme (AAE) consensus motif; other site 446468000192 CoA binding site [chemical binding]; other site 446468000193 Peptidase family M23; Region: Peptidase_M23; pfam01551 446468000194 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 446468000195 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 446468000196 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446468000197 DNA binding site [nucleotide binding] 446468000198 active site 446468000199 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 446468000200 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 446468000201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468000202 AlkA N-terminal domain; Region: AlkA_N; pfam06029 446468000203 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 446468000204 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446468000205 minor groove reading motif; other site 446468000206 helix-hairpin-helix signature motif; other site 446468000207 substrate binding pocket [chemical binding]; other site 446468000208 active site 446468000209 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 446468000210 B12 binding site [chemical binding]; other site 446468000211 cobalt ligand [ion binding]; other site 446468000212 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446468000213 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446468000214 CoA-ligase; Region: Ligase_CoA; pfam00549 446468000215 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446468000216 CoA binding domain; Region: CoA_binding; smart00881 446468000217 CoA-ligase; Region: Ligase_CoA; pfam00549 446468000218 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468000219 Protein of unknown function (DUF805); Region: DUF805; cl01224 446468000220 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 446468000221 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 446468000222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468000223 ATP binding site [chemical binding]; other site 446468000224 putative Mg++ binding site [ion binding]; other site 446468000225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468000226 nucleotide binding region [chemical binding]; other site 446468000227 ATP-binding site [chemical binding]; other site 446468000228 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 446468000229 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 446468000230 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468000231 active site 446468000232 nucleotide binding site [chemical binding]; other site 446468000233 HIGH motif; other site 446468000234 KMSKS motif; other site 446468000235 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 446468000236 ligand-binding site [chemical binding]; other site 446468000237 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12333 446468000238 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 446468000239 homodimer interface [polypeptide binding]; other site 446468000240 metal binding site [ion binding]; metal-binding site 446468000241 hypothetical protein; Provisional; Region: PRK07236 446468000242 FAD binding domain; Region: FAD_binding_3; pfam01494 446468000243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468000244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468000245 enolase; Provisional; Region: eno; PRK00077 446468000246 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 446468000247 dimer interface [polypeptide binding]; other site 446468000248 metal binding site [ion binding]; metal-binding site 446468000249 substrate binding pocket [chemical binding]; other site 446468000250 Septum formation initiator; Region: DivIC; cl17659 446468000251 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 446468000252 Protein of unknown function (DUF501); Region: DUF501; pfam04417 446468000253 exopolyphosphatase; Region: exo_poly_only; TIGR03706 446468000254 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 446468000255 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446468000256 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 446468000257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468000258 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468000259 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446468000260 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 446468000261 NAD(P) binding site [chemical binding]; other site 446468000262 catalytic residues [active] 446468000263 Proline dehydrogenase; Region: Pro_dh; cl03282 446468000264 Bax inhibitor 1 like; Region: BaxI_1; cl17691 446468000265 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 446468000266 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 446468000267 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446468000268 dimer interface [polypeptide binding]; other site 446468000269 active site 446468000270 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 446468000271 active site 446468000272 catalytic triad [active] 446468000273 oxyanion hole [active] 446468000274 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 446468000275 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446468000276 dimer interface [polypeptide binding]; other site 446468000277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468000278 catalytic residue [active] 446468000279 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 446468000280 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 446468000281 trimer interface [polypeptide binding]; other site 446468000282 active site 446468000283 substrate binding site [chemical binding]; other site 446468000284 CoA binding site [chemical binding]; other site 446468000285 cystathionine gamma-synthase; Provisional; Region: PRK07811 446468000286 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446468000287 homodimer interface [polypeptide binding]; other site 446468000288 substrate-cofactor binding pocket; other site 446468000289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468000290 catalytic residue [active] 446468000291 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468000292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468000293 DNA-binding site [nucleotide binding]; DNA binding site 446468000294 UTRA domain; Region: UTRA; pfam07702 446468000295 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468000296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468000297 DNA-binding site [nucleotide binding]; DNA binding site 446468000298 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446468000299 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 446468000300 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446468000301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 446468000302 FIST N domain; Region: FIST; pfam08495 446468000303 FIST C domain; Region: FIST_C; pfam10442 446468000304 RDD family; Region: RDD; pfam06271 446468000305 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 446468000306 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 446468000307 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446468000308 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 446468000309 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446468000310 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 446468000311 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 446468000312 catalytic residues [active] 446468000313 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468000314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468000315 active site 446468000316 ATP binding site [chemical binding]; other site 446468000317 substrate binding site [chemical binding]; other site 446468000318 activation loop (A-loop); other site 446468000319 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446468000320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468000321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468000322 DNA binding residues [nucleotide binding] 446468000323 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446468000324 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446468000325 catalytic residue [active] 446468000326 putative FPP diphosphate binding site; other site 446468000327 putative FPP binding hydrophobic cleft; other site 446468000328 dimer interface [polypeptide binding]; other site 446468000329 putative IPP diphosphate binding site; other site 446468000330 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 446468000331 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 446468000332 putative active site [active] 446468000333 PhoH-like protein; Region: PhoH; pfam02562 446468000334 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446468000335 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446468000336 catalytic residue [active] 446468000337 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446468000338 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446468000339 catalytic residue [active] 446468000340 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468000341 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468000342 active site 446468000343 ATP binding site [chemical binding]; other site 446468000344 substrate binding site [chemical binding]; other site 446468000345 activation loop (A-loop); other site 446468000346 fumarate hydratase; Reviewed; Region: fumC; PRK00485 446468000347 Class II fumarases; Region: Fumarase_classII; cd01362 446468000348 active site 446468000349 tetramer interface [polypeptide binding]; other site 446468000350 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468000351 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446468000352 RNHCP domain; Region: RNHCP; pfam12647 446468000353 RNHCP domain; Region: RNHCP; pfam12647 446468000354 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468000355 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468000356 Probable transposase; Region: OrfB_IS605; pfam01385 446468000357 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468000358 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 446468000359 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 446468000360 putative active site [active] 446468000361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468000362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468000363 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 446468000364 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 446468000365 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446468000366 DNA binding residues [nucleotide binding] 446468000367 putative dimer interface [polypeptide binding]; other site 446468000368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446468000369 catalytic residues [active] 446468000370 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 446468000371 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 446468000372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468000373 active site 446468000374 DNA binding site [nucleotide binding] 446468000375 Int/Topo IB signature motif; other site 446468000376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468000377 DNA-binding site [nucleotide binding]; DNA binding site 446468000378 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468000379 UTRA domain; Region: UTRA; pfam07702 446468000380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468000381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468000382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468000383 Coenzyme A binding pocket [chemical binding]; other site 446468000384 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 446468000385 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 446468000386 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 446468000387 generic binding surface II; other site 446468000388 generic binding surface I; other site 446468000389 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 446468000390 RmuC family; Region: RmuC; pfam02646 446468000391 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468000392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468000393 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 446468000394 GTP-binding protein YchF; Reviewed; Region: PRK09601 446468000395 YchF GTPase; Region: YchF; cd01900 446468000396 G1 box; other site 446468000397 GTP/Mg2+ binding site [chemical binding]; other site 446468000398 Switch I region; other site 446468000399 G2 box; other site 446468000400 Switch II region; other site 446468000401 G3 box; other site 446468000402 G4 box; other site 446468000403 G5 box; other site 446468000404 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 446468000405 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446468000406 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 446468000407 putative acyl-acceptor binding pocket; other site 446468000408 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 446468000409 TcpE family; Region: TcpE; pfam12648 446468000410 AAA domain; Region: AAA_31; pfam13614 446468000411 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446468000412 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446468000413 AAA-like domain; Region: AAA_10; pfam12846 446468000414 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 446468000415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468000416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468000417 active site 446468000418 ATP binding site [chemical binding]; other site 446468000419 substrate binding site [chemical binding]; other site 446468000420 activation loop (A-loop); other site 446468000421 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468000422 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468000423 thymidine kinase; Provisional; Region: PRK04296 446468000424 Ion transport protein; Region: Ion_trans; pfam00520 446468000425 Ribosomal protein L21e; Region: Ribosomal_L21e; cl00937 446468000426 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 446468000427 Leucine-rich repeats; other site 446468000428 Substrate binding site [chemical binding]; other site 446468000429 Family of unknown function (DUF695); Region: DUF695; pfam05117 446468000430 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 446468000431 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 446468000432 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446468000433 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 446468000434 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 446468000435 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 446468000436 nucleotide binding pocket [chemical binding]; other site 446468000437 K-X-D-G motif; other site 446468000438 catalytic site [active] 446468000439 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 446468000440 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 446468000441 Helix-hairpin-helix motif; Region: HHH; pfam00633 446468000442 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 446468000443 Dimer interface [polypeptide binding]; other site 446468000444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446468000445 metal binding site [ion binding]; metal-binding site 446468000446 active site 446468000447 I-site; other site 446468000448 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446468000449 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 446468000450 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446468000451 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 446468000452 TQXA domain; Region: TQXA_dom; TIGR03934 446468000453 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446468000454 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 446468000455 TQXA domain; Region: TQXA_dom; TIGR03934 446468000456 TQXA domain; Region: TQXA_dom; TIGR03934 446468000457 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 446468000458 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 446468000459 GatB domain; Region: GatB_Yqey; smart00845 446468000460 PAS domain S-box; Region: sensory_box; TIGR00229 446468000461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468000462 putative active site [active] 446468000463 heme pocket [chemical binding]; other site 446468000464 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446468000465 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446468000466 metal binding site [ion binding]; metal-binding site 446468000467 active site 446468000468 I-site; other site 446468000469 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 446468000470 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 446468000471 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446468000472 PYR/PP interface [polypeptide binding]; other site 446468000473 dimer interface [polypeptide binding]; other site 446468000474 TPP binding site [chemical binding]; other site 446468000475 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446468000476 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 446468000477 TPP-binding site [chemical binding]; other site 446468000478 dimer interface [polypeptide binding]; other site 446468000479 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 446468000480 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 446468000481 putative valine binding site [chemical binding]; other site 446468000482 dimer interface [polypeptide binding]; other site 446468000483 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 446468000484 ketol-acid reductoisomerase; Provisional; Region: PRK05479 446468000485 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 446468000486 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 446468000487 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 446468000488 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 446468000489 ligand binding site [chemical binding]; other site 446468000490 NAD binding site [chemical binding]; other site 446468000491 dimerization interface [polypeptide binding]; other site 446468000492 catalytic site [active] 446468000493 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 446468000494 putative L-serine binding site [chemical binding]; other site 446468000495 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 446468000496 tartrate dehydrogenase; Region: TTC; TIGR02089 446468000497 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 446468000498 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 446468000499 homodimer interface [polypeptide binding]; other site 446468000500 substrate-cofactor binding pocket; other site 446468000501 catalytic residue [active] 446468000502 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 446468000503 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 446468000504 active site 446468000505 catalytic residues [active] 446468000506 metal binding site [ion binding]; metal-binding site 446468000507 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 446468000508 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 446468000509 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 446468000510 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 446468000511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446468000512 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446468000513 active site 446468000514 oxyanion hole [active] 446468000515 catalytic triad [active] 446468000516 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 446468000517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468000518 active site 446468000519 HIGH motif; other site 446468000520 nucleotide binding site [chemical binding]; other site 446468000521 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 446468000522 active site 446468000523 KMSKS motif; other site 446468000524 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446468000525 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468000526 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468000527 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 446468000528 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 446468000529 substrate binding site [chemical binding]; other site 446468000530 ligand binding site [chemical binding]; other site 446468000531 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 446468000532 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 446468000533 substrate binding site [chemical binding]; other site 446468000534 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 446468000535 IHF dimer interface [polypeptide binding]; other site 446468000536 IHF - DNA interface [nucleotide binding]; other site 446468000537 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 446468000538 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446468000539 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446468000540 putative acyl-acceptor binding pocket; other site 446468000541 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 446468000542 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 446468000543 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 446468000544 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 446468000545 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446468000546 homodimer interface [polypeptide binding]; other site 446468000547 substrate-cofactor binding pocket; other site 446468000548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468000549 catalytic residue [active] 446468000550 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446468000551 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446468000552 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468000553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468000554 putative active site [active] 446468000555 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 446468000556 RNA ligase; Region: RNA_ligase; pfam09414 446468000557 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 446468000558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468000559 Walker A/P-loop; other site 446468000560 ATP binding site [chemical binding]; other site 446468000561 Q-loop/lid; other site 446468000562 ABC transporter signature motif; other site 446468000563 Walker B; other site 446468000564 D-loop; other site 446468000565 H-loop/switch region; other site 446468000566 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 446468000567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468000568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468000569 Walker A/P-loop; other site 446468000570 ATP binding site [chemical binding]; other site 446468000571 Q-loop/lid; other site 446468000572 ABC transporter signature motif; other site 446468000573 Walker B; other site 446468000574 D-loop; other site 446468000575 H-loop/switch region; other site 446468000576 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 446468000577 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446468000578 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446468000579 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446468000580 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446468000581 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 446468000582 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 446468000583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468000584 AsnC family; Region: AsnC_trans_reg; pfam01037 446468000585 thiamine monophosphate kinase; Provisional; Region: PRK05731 446468000586 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 446468000587 ATP binding site [chemical binding]; other site 446468000588 dimerization interface [polypeptide binding]; other site 446468000589 Cellulose binding domain; Region: CBM_2; cl17741 446468000590 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 446468000591 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 446468000592 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 446468000593 generic binding surface II; other site 446468000594 ssDNA binding site; other site 446468000595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468000596 ATP binding site [chemical binding]; other site 446468000597 putative Mg++ binding site [ion binding]; other site 446468000598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468000599 nucleotide binding region [chemical binding]; other site 446468000600 ATP-binding site [chemical binding]; other site 446468000601 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 446468000602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468000603 S-adenosylmethionine binding site [chemical binding]; other site 446468000604 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 446468000605 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 446468000606 active site 446468000607 (T/H)XGH motif; other site 446468000608 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 446468000609 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 446468000610 ribonuclease III; Reviewed; Region: rnc; PRK00102 446468000611 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 446468000612 dimerization interface [polypeptide binding]; other site 446468000613 active site 446468000614 metal binding site [ion binding]; metal-binding site 446468000615 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 446468000616 dsRNA binding site [nucleotide binding]; other site 446468000617 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 446468000618 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 446468000619 DNA binding site [nucleotide binding] 446468000620 catalytic residue [active] 446468000621 H2TH interface [polypeptide binding]; other site 446468000622 putative catalytic residues [active] 446468000623 turnover-facilitating residue; other site 446468000624 intercalation triad [nucleotide binding]; other site 446468000625 8OG recognition residue [nucleotide binding]; other site 446468000626 putative reading head residues; other site 446468000627 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446468000628 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446468000629 acylphosphatase; Provisional; Region: PRK14422 446468000630 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446468000631 AAA domain; Region: AAA_23; pfam13476 446468000632 Walker A/P-loop; other site 446468000633 ATP binding site [chemical binding]; other site 446468000634 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 446468000635 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 446468000636 ABC transporter signature motif; other site 446468000637 Walker B; other site 446468000638 D-loop; other site 446468000639 H-loop/switch region; other site 446468000640 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446468000641 Peptidase S8 family domain, uncharacterized subfamily 5; Region: Peptidases_S8_5; cd07489 446468000642 active site 446468000643 catalytic triad [active] 446468000644 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 446468000645 PA/protease or protease-like domain interface [polypeptide binding]; other site 446468000646 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446468000647 catalytic residues [active] 446468000648 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 446468000649 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468000650 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468000651 intersubunit interface [polypeptide binding]; other site 446468000652 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468000653 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468000654 ABC-ATPase subunit interface; other site 446468000655 putative PBP binding regions; other site 446468000656 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 446468000657 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 446468000658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468000659 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 446468000660 signal recognition particle protein; Provisional; Region: PRK10867 446468000661 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 446468000662 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 446468000663 P loop; other site 446468000664 GTP binding site [chemical binding]; other site 446468000665 Signal peptide binding domain; Region: SRP_SPB; pfam02978 446468000666 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 446468000667 hypothetical protein; Provisional; Region: PRK02821 446468000668 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 446468000669 G-X-X-G motif; other site 446468000670 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 446468000671 RimM N-terminal domain; Region: RimM; pfam01782 446468000672 PRC-barrel domain; Region: PRC; pfam05239 446468000673 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 446468000674 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 446468000675 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 446468000676 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 446468000677 Catalytic site [active] 446468000678 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 446468000679 hypothetical protein; Reviewed; Region: PRK12497 446468000680 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 446468000681 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446468000682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468000683 Walker A motif; other site 446468000684 ATP binding site [chemical binding]; other site 446468000685 Walker B motif; other site 446468000686 arginine finger; other site 446468000687 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 446468000688 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 446468000689 DNA protecting protein DprA; Region: dprA; TIGR00732 446468000690 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468000691 homotrimer interaction site [polypeptide binding]; other site 446468000692 putative active site [active] 446468000693 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446468000694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468000695 active site 446468000696 DNA binding site [nucleotide binding] 446468000697 Int/Topo IB signature motif; other site 446468000698 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 446468000699 rRNA interaction site [nucleotide binding]; other site 446468000700 S8 interaction site; other site 446468000701 putative laminin-1 binding site; other site 446468000702 elongation factor Ts; Provisional; Region: tsf; PRK09377 446468000703 UBA/TS-N domain; Region: UBA; pfam00627 446468000704 Elongation factor TS; Region: EF_TS; pfam00889 446468000705 Elongation factor TS; Region: EF_TS; pfam00889 446468000706 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 446468000707 putative nucleotide binding site [chemical binding]; other site 446468000708 uridine monophosphate binding site [chemical binding]; other site 446468000709 homohexameric interface [polypeptide binding]; other site 446468000710 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 446468000711 ribosome recycling factor; Reviewed; Region: frr; PRK00083 446468000712 hinge region; other site 446468000713 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 446468000714 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 446468000715 aminotransferase; Validated; Region: PRK07777 446468000716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468000717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468000718 homodimer interface [polypeptide binding]; other site 446468000719 catalytic residue [active] 446468000720 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446468000721 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468000722 glycogen branching enzyme; Provisional; Region: PRK05402 446468000723 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 446468000724 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 446468000725 active site 446468000726 catalytic site [active] 446468000727 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 446468000728 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 446468000729 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 446468000730 trehalose synthase; Region: treS_nterm; TIGR02456 446468000731 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 446468000732 active site 446468000733 catalytic site [active] 446468000734 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 446468000735 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 446468000736 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 446468000737 active site 446468000738 homodimer interface [polypeptide binding]; other site 446468000739 catalytic site [active] 446468000740 acceptor binding site [chemical binding]; other site 446468000741 Transglycosylase; Region: Transgly; pfam00912 446468000742 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 446468000743 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446468000744 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 446468000745 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446468000746 Walker A/P-loop; other site 446468000747 ATP binding site [chemical binding]; other site 446468000748 ABC transporter; Region: ABC_tran; pfam00005 446468000749 Q-loop/lid; other site 446468000750 ABC transporter signature motif; other site 446468000751 Walker B; other site 446468000752 D-loop; other site 446468000753 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446468000754 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446468000755 Walker A/P-loop; other site 446468000756 ATP binding site [chemical binding]; other site 446468000757 Q-loop/lid; other site 446468000758 ABC transporter signature motif; other site 446468000759 Walker B; other site 446468000760 D-loop; other site 446468000761 H-loop/switch region; other site 446468000762 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 446468000763 enoyl-CoA hydratase; Provisional; Region: PRK07657 446468000764 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468000765 substrate binding site [chemical binding]; other site 446468000766 oxyanion hole (OAH) forming residues; other site 446468000767 trimer interface [polypeptide binding]; other site 446468000768 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468000769 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468000770 active site 446468000771 ATP binding site [chemical binding]; other site 446468000772 substrate binding site [chemical binding]; other site 446468000773 activation loop (A-loop); other site 446468000774 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446468000775 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 446468000776 Ligand binding site [chemical binding]; other site 446468000777 Electron transfer flavoprotein domain; Region: ETF; pfam01012 446468000778 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 446468000779 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 446468000780 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 446468000781 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 446468000782 nucleotide binding site [chemical binding]; other site 446468000783 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446468000784 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446468000785 Domain of unknown function DUF21; Region: DUF21; pfam01595 446468000786 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446468000787 Transporter associated domain; Region: CorC_HlyC; smart01091 446468000788 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446468000789 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468000790 NAD(P) binding site [chemical binding]; other site 446468000791 catalytic residues [active] 446468000792 Methyltransferase domain; Region: Methyltransf_11; pfam08241 446468000793 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446468000794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468000795 S-adenosylmethionine binding site [chemical binding]; other site 446468000796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 446468000797 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 446468000798 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446468000799 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 446468000800 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 446468000801 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 446468000802 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468000803 FAD binding domain; Region: FAD_binding_4; pfam01565 446468000804 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446468000805 short chain dehydrogenase; Validated; Region: PRK08264 446468000806 classical (c) SDRs; Region: SDR_c; cd05233 446468000807 NAD(P) binding site [chemical binding]; other site 446468000808 active site 446468000809 MFS/sugar transport protein; Region: MFS_2; pfam13347 446468000810 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 446468000811 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446468000812 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 446468000813 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446468000814 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468000815 G1 box; other site 446468000816 GTP/Mg2+ binding site [chemical binding]; other site 446468000817 G2 box; other site 446468000818 Switch I region; other site 446468000819 G3 box; other site 446468000820 Switch II region; other site 446468000821 G5 box; other site 446468000822 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468000823 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 446468000824 Nitrate and nitrite sensing; Region: NIT; pfam08376 446468000825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468000826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468000827 ATP binding site [chemical binding]; other site 446468000828 Mg2+ binding site [ion binding]; other site 446468000829 G-X-G motif; other site 446468000830 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 446468000831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468000832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468000833 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 446468000834 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 446468000835 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468000836 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446468000837 Walker A/P-loop; other site 446468000838 ATP binding site [chemical binding]; other site 446468000839 Q-loop/lid; other site 446468000840 ABC transporter signature motif; other site 446468000841 Walker B; other site 446468000842 D-loop; other site 446468000843 H-loop/switch region; other site 446468000844 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 446468000845 Active_site [active] 446468000846 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 446468000847 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 446468000848 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446468000849 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446468000850 active site 446468000851 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446468000852 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 446468000853 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446468000854 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446468000855 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 446468000856 metal binding site [ion binding]; metal-binding site 446468000857 putative dimer interface [polypeptide binding]; other site 446468000858 Peptidase family M48; Region: Peptidase_M48; pfam01435 446468000859 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 446468000860 elongation factor G; Reviewed; Region: PRK12740 446468000861 G1 box; other site 446468000862 putative GEF interaction site [polypeptide binding]; other site 446468000863 GTP/Mg2+ binding site [chemical binding]; other site 446468000864 Switch I region; other site 446468000865 G2 box; other site 446468000866 G3 box; other site 446468000867 Switch II region; other site 446468000868 G4 box; other site 446468000869 G5 box; other site 446468000870 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446468000871 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 446468000872 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446468000873 CAAX protease self-immunity; Region: Abi; pfam02517 446468000874 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468000875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468000876 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468000877 putative substrate translocation pore; other site 446468000878 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446468000879 active site 446468000880 catalytic residues [active] 446468000881 metal binding site [ion binding]; metal-binding site 446468000882 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446468000883 active site 446468000884 NTP binding site [chemical binding]; other site 446468000885 metal binding triad [ion binding]; metal-binding site 446468000886 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 446468000887 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446468000888 active site 446468000889 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 446468000890 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 446468000891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468000892 active site 446468000893 phosphorylation site [posttranslational modification] 446468000894 intermolecular recognition site; other site 446468000895 dimerization interface [polypeptide binding]; other site 446468000896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468000897 DNA binding site [nucleotide binding] 446468000898 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446468000899 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446468000900 Ligand Binding Site [chemical binding]; other site 446468000901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468000902 dimer interface [polypeptide binding]; other site 446468000903 phosphorylation site [posttranslational modification] 446468000904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468000905 ATP binding site [chemical binding]; other site 446468000906 G-X-G motif; other site 446468000907 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468000908 FAD binding domain; Region: FAD_binding_4; pfam01565 446468000909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468000910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468000911 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446468000912 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468000913 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468000914 bile acid transporter; Region: bass; TIGR00841 446468000915 Sodium Bile acid symporter family; Region: SBF; cl17470 446468000916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468000917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468000918 active site 446468000919 phosphorylation site [posttranslational modification] 446468000920 intermolecular recognition site; other site 446468000921 dimerization interface [polypeptide binding]; other site 446468000922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468000923 DNA binding residues [nucleotide binding] 446468000924 Putative sensor; Region: Sensor; pfam13796 446468000925 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468000926 Histidine kinase; Region: HisKA_3; pfam07730 446468000927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468000928 Mg2+ binding site [ion binding]; other site 446468000929 G-X-G motif; other site 446468000930 Histidine kinase; Region: HisKA_3; pfam07730 446468000931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468000932 ATP binding site [chemical binding]; other site 446468000933 Mg2+ binding site [ion binding]; other site 446468000934 G-X-G motif; other site 446468000935 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446468000936 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446468000937 Walker A/P-loop; other site 446468000938 ATP binding site [chemical binding]; other site 446468000939 Q-loop/lid; other site 446468000940 ABC transporter signature motif; other site 446468000941 Walker B; other site 446468000942 D-loop; other site 446468000943 H-loop/switch region; other site 446468000944 Tubby C 2; Region: Tub_2; cl02043 446468000945 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 446468000946 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446468000947 active site 446468000948 catalytic site [active] 446468000949 substrate binding site [chemical binding]; other site 446468000950 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446468000951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468000952 active site 446468000953 phosphorylation site [posttranslational modification] 446468000954 intermolecular recognition site; other site 446468000955 dimerization interface [polypeptide binding]; other site 446468000956 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446468000957 tRNA binding surface [nucleotide binding]; other site 446468000958 anticodon binding site; other site 446468000959 diaminopimelate decarboxylase; Region: lysA; TIGR01048 446468000960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 446468000961 active site 446468000962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468000963 substrate binding site [chemical binding]; other site 446468000964 catalytic residues [active] 446468000965 dimer interface [polypeptide binding]; other site 446468000966 homoserine dehydrogenase; Provisional; Region: PRK06349 446468000967 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 446468000968 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 446468000969 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 446468000970 threonine synthase; Reviewed; Region: PRK06721 446468000971 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446468000972 homodimer interface [polypeptide binding]; other site 446468000973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468000974 catalytic residue [active] 446468000975 homoserine kinase; Provisional; Region: PRK01212 446468000976 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 446468000977 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 446468000978 transcription termination factor Rho; Provisional; Region: PRK12608 446468000979 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 446468000980 RNA binding site [nucleotide binding]; other site 446468000981 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 446468000982 multimer interface [polypeptide binding]; other site 446468000983 Walker A motif; other site 446468000984 ATP binding site [chemical binding]; other site 446468000985 Walker B motif; other site 446468000986 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 446468000987 L-lactate permease; Region: Lactate_perm; cl00701 446468000988 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 446468000989 peptide chain release factor 1; Validated; Region: prfA; PRK00591 446468000990 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446468000991 RF-1 domain; Region: RF-1; pfam00472 446468000992 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446468000993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468000994 S-adenosylmethionine binding site [chemical binding]; other site 446468000995 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 446468000996 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 446468000997 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 446468000998 Mg++ binding site [ion binding]; other site 446468000999 putative catalytic motif [active] 446468001000 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 446468001001 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 446468001002 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 446468001003 ATP synthase subunit C; Region: ATP-synt_C; cl00466 446468001004 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 446468001005 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 446468001006 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 446468001007 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 446468001008 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446468001009 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 446468001010 beta subunit interaction interface [polypeptide binding]; other site 446468001011 Walker A motif; other site 446468001012 ATP binding site [chemical binding]; other site 446468001013 Walker B motif; other site 446468001014 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446468001015 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 446468001016 core domain interface [polypeptide binding]; other site 446468001017 delta subunit interface [polypeptide binding]; other site 446468001018 epsilon subunit interface [polypeptide binding]; other site 446468001019 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 446468001020 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 446468001021 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 446468001022 alpha subunit interaction interface [polypeptide binding]; other site 446468001023 Walker A motif; other site 446468001024 ATP binding site [chemical binding]; other site 446468001025 Walker B motif; other site 446468001026 inhibitor binding site; inhibition site 446468001027 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 446468001028 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 446468001029 gamma subunit interface [polypeptide binding]; other site 446468001030 epsilon subunit interface [polypeptide binding]; other site 446468001031 LBP interface [polypeptide binding]; other site 446468001032 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 446468001033 Domain of unknown function DUF77; Region: DUF77; pfam01910 446468001034 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 446468001035 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446468001036 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 446468001037 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446468001038 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 446468001039 PA/protease or protease-like domain interface [polypeptide binding]; other site 446468001040 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 446468001041 Peptidase family M28; Region: Peptidase_M28; pfam04389 446468001042 active site 446468001043 metal binding site [ion binding]; metal-binding site 446468001044 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468001045 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446468001046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468001047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468001048 active site 446468001049 phosphorylation site [posttranslational modification] 446468001050 intermolecular recognition site; other site 446468001051 dimerization interface [polypeptide binding]; other site 446468001052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468001053 DNA binding residues [nucleotide binding] 446468001054 dimerization interface [polypeptide binding]; other site 446468001055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468001056 Histidine kinase; Region: HisKA_3; pfam07730 446468001057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468001058 ATP binding site [chemical binding]; other site 446468001059 G-X-G motif; other site 446468001060 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468001061 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446468001062 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468001063 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468001064 Walker A/P-loop; other site 446468001065 ATP binding site [chemical binding]; other site 446468001066 Q-loop/lid; other site 446468001067 ABC transporter signature motif; other site 446468001068 Walker B; other site 446468001069 D-loop; other site 446468001070 H-loop/switch region; other site 446468001071 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 446468001072 hypothetical protein; Provisional; Region: PRK03298 446468001073 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 446468001074 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446468001075 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446468001076 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446468001077 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468001078 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468001079 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 446468001080 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468001081 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 446468001082 dimer interface [polypeptide binding]; other site 446468001083 substrate binding site [chemical binding]; other site 446468001084 metal binding site [ion binding]; metal-binding site 446468001085 putative acyltransferase; Provisional; Region: PRK05790 446468001086 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446468001087 dimer interface [polypeptide binding]; other site 446468001088 active site 446468001089 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 446468001090 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 446468001091 Walker A; other site 446468001092 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468001093 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468001094 active site 446468001095 Cellulose binding domain; Region: CBM_2; pfam00553 446468001096 Glyco_18 domain; Region: Glyco_18; smart00636 446468001097 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446468001098 active site 446468001099 Cellulose binding domain; Region: CBM_2; pfam00553 446468001100 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446468001101 Glyco_18 domain; Region: Glyco_18; smart00636 446468001102 active site 446468001103 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468001104 MarR family; Region: MarR; pfam01047 446468001105 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 446468001106 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 446468001107 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446468001108 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 446468001109 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 446468001110 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 446468001111 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446468001112 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446468001113 putative NAD(P) binding site [chemical binding]; other site 446468001114 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 446468001115 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 446468001116 Htaa; Region: HtaA; pfam04213 446468001117 Htaa; Region: HtaA; pfam04213 446468001118 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 446468001119 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468001120 putative hemin binding site; other site 446468001121 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468001122 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468001123 ABC-ATPase subunit interface; other site 446468001124 dimer interface [polypeptide binding]; other site 446468001125 putative PBP binding regions; other site 446468001126 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 446468001127 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468001128 Walker A/P-loop; other site 446468001129 ATP binding site [chemical binding]; other site 446468001130 Q-loop/lid; other site 446468001131 ABC transporter signature motif; other site 446468001132 Walker B; other site 446468001133 D-loop; other site 446468001134 H-loop/switch region; other site 446468001135 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 446468001136 active site 446468001137 catalytic site [active] 446468001138 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446468001139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468001140 ATP binding site [chemical binding]; other site 446468001141 putative Mg++ binding site [ion binding]; other site 446468001142 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 446468001143 active site 446468001144 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 446468001145 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 446468001146 active site 446468001147 HIGH motif; other site 446468001148 dimer interface [polypeptide binding]; other site 446468001149 KMSKS motif; other site 446468001150 Isochorismatase family; Region: Isochorismatase; pfam00857 446468001151 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446468001152 catalytic triad [active] 446468001153 conserved cis-peptide bond; other site 446468001154 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 446468001155 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 446468001156 active site 446468001157 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 446468001158 MPN+ (JAMM) motif; other site 446468001159 Zinc-binding site [ion binding]; other site 446468001160 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 446468001161 MoaE interaction surface [polypeptide binding]; other site 446468001162 MoeB interaction surface [polypeptide binding]; other site 446468001163 thiocarboxylated glycine; other site 446468001164 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446468001165 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 446468001166 dimer interface [polypeptide binding]; other site 446468001167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468001168 catalytic residue [active] 446468001169 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446468001170 ribonuclease PH; Reviewed; Region: rph; PRK00173 446468001171 Ribonuclease PH; Region: RNase_PH_bact; cd11362 446468001172 hexamer interface [polypeptide binding]; other site 446468001173 active site 446468001174 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 446468001175 active site 446468001176 dimerization interface [polypeptide binding]; other site 446468001177 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446468001178 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446468001179 Transglycosylase; Region: Transgly; pfam00912 446468001180 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446468001181 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 446468001182 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468001183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468001184 S-adenosylmethionine binding site [chemical binding]; other site 446468001185 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468001186 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446468001187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468001188 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468001189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446468001190 quinolinate synthetase; Provisional; Region: PRK09375 446468001191 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446468001192 nudix motif; other site 446468001193 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446468001194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468001195 motif II; other site 446468001196 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446468001197 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 446468001198 Walker A/P-loop; other site 446468001199 ATP binding site [chemical binding]; other site 446468001200 Q-loop/lid; other site 446468001201 ABC transporter signature motif; other site 446468001202 Walker B; other site 446468001203 D-loop; other site 446468001204 H-loop/switch region; other site 446468001205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001206 dimer interface [polypeptide binding]; other site 446468001207 conserved gate region; other site 446468001208 ABC-ATPase subunit interface; other site 446468001209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446468001210 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446468001211 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 446468001212 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 446468001213 tandem repeat interface [polypeptide binding]; other site 446468001214 oligomer interface [polypeptide binding]; other site 446468001215 active site residues [active] 446468001216 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 446468001217 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 446468001218 tandem repeat interface [polypeptide binding]; other site 446468001219 oligomer interface [polypeptide binding]; other site 446468001220 active site residues [active] 446468001221 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446468001222 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446468001223 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446468001224 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446468001225 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446468001226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468001227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468001228 active site 446468001229 ATP binding site [chemical binding]; other site 446468001230 substrate binding site [chemical binding]; other site 446468001231 activation loop (A-loop); other site 446468001232 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446468001233 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 446468001234 catalytic triad [active] 446468001235 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446468001236 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446468001237 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446468001238 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 446468001239 dimer interface [polypeptide binding]; other site 446468001240 active site 446468001241 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468001242 substrate binding site [chemical binding]; other site 446468001243 catalytic residue [active] 446468001244 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 446468001245 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 446468001246 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 446468001247 putative active site [active] 446468001248 putative substrate binding site [chemical binding]; other site 446468001249 putative cosubstrate binding site; other site 446468001250 catalytic site [active] 446468001251 Asp23 family; Region: Asp23; pfam03780 446468001252 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 446468001253 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468001254 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446468001255 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468001256 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 446468001257 active site 446468001258 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446468001259 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446468001260 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446468001261 putative active site [active] 446468001262 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 446468001263 Na binding site [ion binding]; other site 446468001264 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 446468001265 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 446468001266 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 446468001267 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 446468001268 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 446468001269 dimer interface [polypeptide binding]; other site 446468001270 active site 446468001271 glycine-pyridoxal phosphate binding site [chemical binding]; other site 446468001272 folate binding site [chemical binding]; other site 446468001273 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446468001274 lipoyl attachment site [posttranslational modification]; other site 446468001275 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 446468001276 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446468001277 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 446468001278 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 446468001279 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 446468001280 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446468001281 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468001282 acyl-activating enzyme (AAE) consensus motif; other site 446468001283 AMP binding site [chemical binding]; other site 446468001284 active site 446468001285 CoA binding site [chemical binding]; other site 446468001286 Short C-terminal domain; Region: SHOCT; pfam09851 446468001287 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 446468001288 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 446468001289 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446468001290 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 446468001291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446468001292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468001293 L-asparaginase II; Region: Asparaginase_II; pfam06089 446468001294 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446468001295 active site 446468001296 catalytic site [active] 446468001297 substrate binding site [chemical binding]; other site 446468001298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468001299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468001300 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468001301 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446468001302 CGNR zinc finger; Region: zf-CGNR; pfam11706 446468001303 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 446468001304 heme binding pocket [chemical binding]; other site 446468001305 heme ligand [chemical binding]; other site 446468001306 Response regulator receiver domain; Region: Response_reg; pfam00072 446468001307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468001308 active site 446468001309 phosphorylation site [posttranslational modification] 446468001310 intermolecular recognition site; other site 446468001311 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468001312 CHASE3 domain; Region: CHASE3; pfam05227 446468001313 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468001314 dimerization interface [polypeptide binding]; other site 446468001315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468001316 dimer interface [polypeptide binding]; other site 446468001317 phosphorylation site [posttranslational modification] 446468001318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468001319 ATP binding site [chemical binding]; other site 446468001320 Mg2+ binding site [ion binding]; other site 446468001321 G-X-G motif; other site 446468001322 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446468001323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468001324 active site 446468001325 phosphorylation site [posttranslational modification] 446468001326 intermolecular recognition site; other site 446468001327 dimerization interface [polypeptide binding]; other site 446468001328 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446468001329 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 446468001330 active site 446468001331 Fructosamine kinase; Region: Fructosamin_kin; cl17579 446468001332 Phosphotransferase enzyme family; Region: APH; pfam01636 446468001333 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 446468001334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468001335 motif II; other site 446468001336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468001337 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446468001338 active site 446468001339 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 446468001340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468001341 putative NAD(P) binding site [chemical binding]; other site 446468001342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468001343 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468001344 putative oxidoreductase; Provisional; Region: PRK11579 446468001345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468001346 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446468001347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446468001348 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 446468001349 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468001350 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468001351 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446468001352 Helix-turn-helix domain; Region: HTH_38; pfam13936 446468001353 MarR family; Region: MarR_2; cl17246 446468001354 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468001355 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446468001356 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446468001357 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 446468001358 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446468001359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468001360 NAD(P) binding site [chemical binding]; other site 446468001361 active site 446468001362 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 446468001363 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468001364 DNA binding residues [nucleotide binding] 446468001365 putative dimer interface [polypeptide binding]; other site 446468001366 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 446468001367 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446468001368 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446468001369 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446468001370 Family description; Region: UvrD_C_2; pfam13538 446468001371 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468001372 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446468001373 putative active site [active] 446468001374 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446468001375 putative active site [active] 446468001376 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446468001377 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 446468001378 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 446468001379 putative active site [active] 446468001380 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446468001381 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446468001382 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446468001383 putative active site [active] 446468001384 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468001385 Septum formation; Region: Septum_form; pfam13845 446468001386 Septum formation; Region: Septum_form; pfam13845 446468001387 Septum formation; Region: Septum_form; pfam13845 446468001388 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446468001389 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468001390 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468001391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001392 dimer interface [polypeptide binding]; other site 446468001393 conserved gate region; other site 446468001394 putative PBP binding loops; other site 446468001395 ABC-ATPase subunit interface; other site 446468001396 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 446468001397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001398 dimer interface [polypeptide binding]; other site 446468001399 conserved gate region; other site 446468001400 putative PBP binding loops; other site 446468001401 ABC-ATPase subunit interface; other site 446468001402 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468001403 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001404 Walker A/P-loop; other site 446468001405 ATP binding site [chemical binding]; other site 446468001406 Q-loop/lid; other site 446468001407 ABC transporter signature motif; other site 446468001408 Walker B; other site 446468001409 D-loop; other site 446468001410 H-loop/switch region; other site 446468001411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468001412 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468001413 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001414 Walker A/P-loop; other site 446468001415 ATP binding site [chemical binding]; other site 446468001416 Q-loop/lid; other site 446468001417 ABC transporter signature motif; other site 446468001418 Walker B; other site 446468001419 D-loop; other site 446468001420 H-loop/switch region; other site 446468001421 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468001422 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 446468001423 substrate binding site [chemical binding]; other site 446468001424 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468001425 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446468001426 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 446468001427 NAD(P) binding site [chemical binding]; other site 446468001428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468001430 ATP binding site [chemical binding]; other site 446468001431 Mg2+ binding site [ion binding]; other site 446468001432 G-X-G motif; other site 446468001433 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446468001434 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468001435 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446468001436 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468001437 G1 box; other site 446468001438 GTP/Mg2+ binding site [chemical binding]; other site 446468001439 G2 box; other site 446468001440 Switch I region; other site 446468001441 G3 box; other site 446468001442 Switch II region; other site 446468001443 G4 box; other site 446468001444 G5 box; other site 446468001445 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446468001446 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446468001447 active site 446468001448 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446468001449 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446468001450 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446468001451 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446468001452 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446468001453 active site 446468001454 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446468001455 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446468001456 Enoylreductase; Region: PKS_ER; smart00829 446468001457 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446468001458 putative NADP binding site [chemical binding]; other site 446468001459 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446468001460 active site 446468001461 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446468001462 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446468001463 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 446468001464 active site 446468001465 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446468001466 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446468001467 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446468001468 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 446468001469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 446468001470 active site 446468001471 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 446468001472 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 446468001473 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 446468001474 putative NADP binding site [chemical binding]; other site 446468001475 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 446468001476 active site 446468001477 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 446468001478 Thioesterase; Region: PKS_TE; smart00824 446468001479 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 446468001480 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468001481 ATP binding site [chemical binding]; other site 446468001482 putative Mg++ binding site [ion binding]; other site 446468001483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468001484 nucleotide binding region [chemical binding]; other site 446468001485 ATP-binding site [chemical binding]; other site 446468001486 Helicase associated domain (HA2); Region: HA2; pfam04408 446468001487 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 446468001488 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 446468001489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468001490 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 446468001491 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 446468001492 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 446468001493 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 446468001494 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468001495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 446468001496 Walker A/P-loop; other site 446468001497 ATP binding site [chemical binding]; other site 446468001498 Q-loop/lid; other site 446468001499 ABC transporter signature motif; other site 446468001500 Walker B; other site 446468001501 D-loop; other site 446468001502 H-loop/switch region; other site 446468001503 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 446468001504 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446468001505 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 446468001506 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 446468001507 catalytic residues [active] 446468001508 catalytic nucleophile [active] 446468001509 Recombinase; Region: Recombinase; pfam07508 446468001510 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 446468001511 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 446468001512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468001513 non-specific DNA binding site [nucleotide binding]; other site 446468001514 salt bridge; other site 446468001515 sequence-specific DNA binding site [nucleotide binding]; other site 446468001516 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 446468001517 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468001518 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468001519 DNA-binding site [nucleotide binding]; DNA binding site 446468001520 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468001521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468001522 NAD(P) binding site [chemical binding]; other site 446468001523 active site 446468001524 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468001525 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468001526 ATP binding site [chemical binding]; other site 446468001527 Mg2+ binding site [ion binding]; other site 446468001528 G-X-G motif; other site 446468001529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468001530 non-specific DNA binding site [nucleotide binding]; other site 446468001531 salt bridge; other site 446468001532 sequence-specific DNA binding site [nucleotide binding]; other site 446468001533 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468001534 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468001535 intersubunit interface [polypeptide binding]; other site 446468001536 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468001537 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446468001538 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446468001539 TrkA-N domain; Region: TrkA_N; pfam02254 446468001540 TrkA-C domain; Region: TrkA_C; pfam02080 446468001541 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446468001542 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446468001543 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 446468001544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468001545 dimerization interface [polypeptide binding]; other site 446468001546 putative DNA binding site [nucleotide binding]; other site 446468001547 putative Zn2+ binding site [ion binding]; other site 446468001548 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 446468001549 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446468001550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468001551 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468001552 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468001553 DNA binding residues [nucleotide binding] 446468001554 HEAT repeats; Region: HEAT_2; pfam13646 446468001555 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468001556 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468001557 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 446468001558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468001559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001560 putative PBP binding loops; other site 446468001561 dimer interface [polypeptide binding]; other site 446468001562 ABC-ATPase subunit interface; other site 446468001563 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 446468001564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001565 dimer interface [polypeptide binding]; other site 446468001566 conserved gate region; other site 446468001567 putative PBP binding loops; other site 446468001568 ABC-ATPase subunit interface; other site 446468001569 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468001570 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001571 Walker A/P-loop; other site 446468001572 ATP binding site [chemical binding]; other site 446468001573 Q-loop/lid; other site 446468001574 ABC transporter signature motif; other site 446468001575 Walker B; other site 446468001576 D-loop; other site 446468001577 H-loop/switch region; other site 446468001578 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468001579 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446468001580 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001581 Walker A/P-loop; other site 446468001582 ATP binding site [chemical binding]; other site 446468001583 Q-loop/lid; other site 446468001584 ABC transporter signature motif; other site 446468001585 Walker B; other site 446468001586 D-loop; other site 446468001587 H-loop/switch region; other site 446468001588 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446468001589 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446468001590 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468001591 Amb_all domain; Region: Amb_all; smart00656 446468001592 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468001593 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 446468001594 putative ADP-binding pocket [chemical binding]; other site 446468001595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446468001596 Interdomain contacts; other site 446468001597 Cytokine receptor motif; other site 446468001598 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 446468001599 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 446468001600 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468001601 WHG domain; Region: WHG; pfam13305 446468001602 short chain dehydrogenase; Provisional; Region: PRK12937 446468001603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468001604 NAD(P) binding site [chemical binding]; other site 446468001605 active site 446468001606 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 446468001607 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 446468001608 NAD binding site [chemical binding]; other site 446468001609 ligand binding site [chemical binding]; other site 446468001610 catalytic site [active] 446468001611 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468001612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468001613 DNA-binding site [nucleotide binding]; DNA binding site 446468001614 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468001615 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 446468001616 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446468001617 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446468001618 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 446468001619 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446468001620 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446468001621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468001622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468001623 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446468001624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001625 dimer interface [polypeptide binding]; other site 446468001626 conserved gate region; other site 446468001627 putative PBP binding loops; other site 446468001628 ABC-ATPase subunit interface; other site 446468001629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468001630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001631 dimer interface [polypeptide binding]; other site 446468001632 conserved gate region; other site 446468001633 putative PBP binding loops; other site 446468001634 ABC-ATPase subunit interface; other site 446468001635 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 446468001636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468001637 DNA-binding site [nucleotide binding]; DNA binding site 446468001638 FCD domain; Region: FCD; pfam07729 446468001639 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 446468001640 catalytic site [active] 446468001641 putative active site [active] 446468001642 putative substrate binding site [chemical binding]; other site 446468001643 dimer interface [polypeptide binding]; other site 446468001644 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 446468001645 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446468001646 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446468001647 metal ion-dependent adhesion site (MIDAS); other site 446468001648 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446468001649 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446468001650 metal ion-dependent adhesion site (MIDAS); other site 446468001651 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446468001652 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446468001653 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 446468001654 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 446468001655 putative ligand binding site [chemical binding]; other site 446468001656 putative NAD binding site [chemical binding]; other site 446468001657 catalytic site [active] 446468001658 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 446468001659 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 446468001660 active site 446468001661 DNA binding site [nucleotide binding] 446468001662 catalytic site [active] 446468001663 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468001664 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468001665 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 446468001666 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 446468001667 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446468001668 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446468001669 active site 446468001670 catalytic site [active] 446468001671 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 446468001672 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 446468001673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468001674 catalytic residue [active] 446468001675 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446468001676 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 446468001677 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446468001678 active site 446468001679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468001680 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 446468001681 putative ADP-binding pocket [chemical binding]; other site 446468001682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468001683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468001684 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468001685 dimerization interface [polypeptide binding]; other site 446468001686 aspartate aminotransferase; Provisional; Region: PRK05764 446468001687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468001688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468001689 homodimer interface [polypeptide binding]; other site 446468001690 catalytic residue [active] 446468001691 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468001692 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 446468001693 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446468001694 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446468001695 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446468001696 nudix motif; other site 446468001697 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 446468001698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468001699 DNA-binding site [nucleotide binding]; DNA binding site 446468001700 UTRA domain; Region: UTRA; pfam07702 446468001701 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 446468001702 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446468001703 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468001704 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 446468001705 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 446468001706 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; Region: SUA7; COG1405 446468001707 Helix-turn-helix domain; Region: HTH_17; pfam12728 446468001708 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468001709 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468001710 active site 446468001711 DNA binding site [nucleotide binding] 446468001712 Int/Topo IB signature motif; other site 446468001713 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446468001714 dimer interface [polypeptide binding]; other site 446468001715 substrate binding site [chemical binding]; other site 446468001716 ATP binding site [chemical binding]; other site 446468001717 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446468001718 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446468001719 Domain of unknown function (DUF368); Region: DUF368; pfam04018 446468001720 acyl-CoA synthetase; Validated; Region: PRK07798 446468001721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468001722 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 446468001723 acyl-activating enzyme (AAE) consensus motif; other site 446468001724 acyl-activating enzyme (AAE) consensus motif; other site 446468001725 putative AMP binding site [chemical binding]; other site 446468001726 putative active site [active] 446468001727 putative CoA binding site [chemical binding]; other site 446468001728 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468001729 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 446468001730 inhibitor-cofactor binding pocket; inhibition site 446468001731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468001732 catalytic residue [active] 446468001733 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446468001734 active site 446468001735 oxyanion hole [active] 446468001736 catalytic triad [active] 446468001737 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468001738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468001739 catalytic residue [active] 446468001740 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468001741 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 446468001742 inhibitor-cofactor binding pocket; inhibition site 446468001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468001744 catalytic residue [active] 446468001745 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 446468001746 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 446468001747 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446468001748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468001749 DNA-binding site [nucleotide binding]; DNA binding site 446468001750 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468001751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468001752 homodimer interface [polypeptide binding]; other site 446468001753 catalytic residue [active] 446468001754 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 446468001755 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 446468001756 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 446468001757 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446468001758 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446468001759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468001760 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 446468001761 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 446468001762 active site 446468001763 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 446468001764 putative active site [active] 446468001765 putative catalytic site [active] 446468001766 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446468001767 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 446468001768 metal binding site [ion binding]; metal-binding site 446468001769 substrate binding pocket [chemical binding]; other site 446468001770 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 446468001771 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 446468001772 hexamer interface [polypeptide binding]; other site 446468001773 ligand binding site [chemical binding]; other site 446468001774 putative active site [active] 446468001775 NAD(P) binding site [chemical binding]; other site 446468001776 allantoinase; Region: allantoinase; TIGR03178 446468001777 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468001778 active site 446468001779 Copper resistance protein D; Region: CopD; cl00563 446468001780 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446468001781 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446468001782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468001783 Walker A/P-loop; other site 446468001784 ATP binding site [chemical binding]; other site 446468001785 Q-loop/lid; other site 446468001786 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 446468001787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468001788 ABC transporter signature motif; other site 446468001789 Walker B; other site 446468001790 D-loop; other site 446468001791 H-loop/switch region; other site 446468001792 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 446468001793 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468001794 active site 446468001795 metal binding site [ion binding]; metal-binding site 446468001796 DNA binding site [nucleotide binding] 446468001797 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 446468001798 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446468001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468001800 S-adenosylmethionine binding site [chemical binding]; other site 446468001801 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 446468001802 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446468001803 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 446468001804 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468001805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001806 dimer interface [polypeptide binding]; other site 446468001807 conserved gate region; other site 446468001808 putative PBP binding loops; other site 446468001809 ABC-ATPase subunit interface; other site 446468001810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468001811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001812 dimer interface [polypeptide binding]; other site 446468001813 ABC-ATPase subunit interface; other site 446468001814 putative PBP binding loops; other site 446468001815 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468001816 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001817 Walker A/P-loop; other site 446468001818 ATP binding site [chemical binding]; other site 446468001819 Q-loop/lid; other site 446468001820 ABC transporter signature motif; other site 446468001821 Walker B; other site 446468001822 D-loop; other site 446468001823 H-loop/switch region; other site 446468001824 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468001825 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468001826 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468001827 Walker A/P-loop; other site 446468001828 ATP binding site [chemical binding]; other site 446468001829 Q-loop/lid; other site 446468001830 ABC transporter signature motif; other site 446468001831 Walker B; other site 446468001832 D-loop; other site 446468001833 H-loop/switch region; other site 446468001834 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468001835 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 446468001836 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446468001837 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 446468001838 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446468001839 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 446468001840 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 446468001841 putative active site [active] 446468001842 putative dimer interface [polypeptide binding]; other site 446468001843 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 446468001844 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 446468001845 dihydrodipicolinate reductase; Provisional; Region: PRK00048 446468001846 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 446468001847 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 446468001848 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446468001849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468001850 S-adenosylmethionine binding site [chemical binding]; other site 446468001851 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 446468001852 UbiA prenyltransferase family; Region: UbiA; pfam01040 446468001853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468001854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468001855 Coenzyme A binding pocket [chemical binding]; other site 446468001856 Predicted membrane protein [Function unknown]; Region: COG1950 446468001857 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446468001858 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 446468001859 dimer interface [polypeptide binding]; other site 446468001860 active site 446468001861 catalytic residue [active] 446468001862 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 446468001863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468001864 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 446468001865 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 446468001866 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468001867 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 446468001868 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 446468001869 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 446468001870 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446468001871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468001872 FeS/SAM binding site; other site 446468001873 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446468001874 Competence-damaged protein; Region: CinA; pfam02464 446468001875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468001876 sequence-specific DNA binding site [nucleotide binding]; other site 446468001877 salt bridge; other site 446468001878 Predicted transcriptional regulator [Transcription]; Region: COG1959 446468001879 Transcriptional regulator; Region: Rrf2; pfam02082 446468001880 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446468001881 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446468001882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468001883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001884 dimer interface [polypeptide binding]; other site 446468001885 conserved gate region; other site 446468001886 putative PBP binding loops; other site 446468001887 ABC-ATPase subunit interface; other site 446468001888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001889 dimer interface [polypeptide binding]; other site 446468001890 putative PBP binding loops; other site 446468001891 ABC-ATPase subunit interface; other site 446468001892 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468001893 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446468001894 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468001895 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468001896 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468001897 Coenzyme A binding pocket [chemical binding]; other site 446468001898 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446468001899 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446468001900 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446468001901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468001902 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468001903 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468001904 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 446468001905 ATP binding site [chemical binding]; other site 446468001906 putative Mg++ binding site [ion binding]; other site 446468001907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468001908 nucleotide binding region [chemical binding]; other site 446468001909 ATP-binding site [chemical binding]; other site 446468001910 DEAD/H associated; Region: DEAD_assoc; pfam08494 446468001911 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 446468001912 recombinase A; Provisional; Region: recA; PRK09354 446468001913 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 446468001914 hexamer interface [polypeptide binding]; other site 446468001915 Walker A motif; other site 446468001916 ATP binding site [chemical binding]; other site 446468001917 Walker B motif; other site 446468001918 recombination regulator RecX; Reviewed; Region: recX; PRK00117 446468001919 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468001920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001922 dimer interface [polypeptide binding]; other site 446468001923 conserved gate region; other site 446468001924 putative PBP binding loops; other site 446468001925 ABC-ATPase subunit interface; other site 446468001926 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446468001927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468001928 dimer interface [polypeptide binding]; other site 446468001929 conserved gate region; other site 446468001930 putative PBP binding loops; other site 446468001931 ABC-ATPase subunit interface; other site 446468001932 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446468001933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446468001934 substrate binding pocket [chemical binding]; other site 446468001935 membrane-bound complex binding site; other site 446468001936 hinge residues; other site 446468001937 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446468001938 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446468001939 Walker A/P-loop; other site 446468001940 ATP binding site [chemical binding]; other site 446468001941 Q-loop/lid; other site 446468001942 ABC transporter signature motif; other site 446468001943 Walker B; other site 446468001944 D-loop; other site 446468001945 H-loop/switch region; other site 446468001946 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 446468001947 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 446468001948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468001949 FeS/SAM binding site; other site 446468001950 TRAM domain; Region: TRAM; cl01282 446468001951 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468001952 Cytochrome P450; Region: p450; cl12078 446468001953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468001954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468001955 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 446468001956 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 446468001957 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 446468001958 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446468001959 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 446468001960 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446468001961 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468001962 DNA binding residues [nucleotide binding] 446468001963 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446468001964 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 446468001965 Cysteine-rich domain; Region: CCG; pfam02754 446468001966 Cysteine-rich domain; Region: CCG; pfam02754 446468001967 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468001968 FAD binding domain; Region: FAD_binding_4; pfam01565 446468001969 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 446468001970 FAD binding domain; Region: FAD_binding_4; pfam01565 446468001971 malate synthase A; Region: malate_syn_A; TIGR01344 446468001972 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 446468001973 active site 446468001974 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 446468001975 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 446468001976 HflX GTPase family; Region: HflX; cd01878 446468001977 G1 box; other site 446468001978 GTP/Mg2+ binding site [chemical binding]; other site 446468001979 Switch I region; other site 446468001980 G2 box; other site 446468001981 G3 box; other site 446468001982 Switch II region; other site 446468001983 G4 box; other site 446468001984 G5 box; other site 446468001985 imidazolonepropionase; Validated; Region: PRK09356 446468001986 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 446468001987 active site 446468001988 hypothetical protein; Reviewed; Region: PRK07914 446468001989 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 446468001990 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 446468001991 Competence protein; Region: Competence; pfam03772 446468001992 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468001993 SLBB domain; Region: SLBB; pfam10531 446468001994 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 446468001995 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 446468001996 GTP-binding protein LepA; Provisional; Region: PRK05433 446468001997 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 446468001998 G1 box; other site 446468001999 putative GEF interaction site [polypeptide binding]; other site 446468002000 GTP/Mg2+ binding site [chemical binding]; other site 446468002001 Switch I region; other site 446468002002 G2 box; other site 446468002003 G3 box; other site 446468002004 Switch II region; other site 446468002005 G4 box; other site 446468002006 G5 box; other site 446468002007 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 446468002008 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 446468002009 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 446468002010 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468002011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468002012 dimer interface [polypeptide binding]; other site 446468002013 conserved gate region; other site 446468002014 putative PBP binding loops; other site 446468002015 ABC-ATPase subunit interface; other site 446468002016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468002017 dimer interface [polypeptide binding]; other site 446468002018 conserved gate region; other site 446468002019 putative PBP binding loops; other site 446468002020 ABC-ATPase subunit interface; other site 446468002021 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 446468002022 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468002023 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446468002024 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446468002025 active site 446468002026 catalytic site [active] 446468002027 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446468002028 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468002029 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468002030 DNA binding site [nucleotide binding] 446468002031 domain linker motif; other site 446468002032 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 446468002033 putative dimerization interface [polypeptide binding]; other site 446468002034 putative ligand binding site [chemical binding]; other site 446468002035 coproporphyrinogen III oxidase; Validated; Region: PRK05628 446468002036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468002037 FeS/SAM binding site; other site 446468002038 Tic20-like protein; Region: Tic20; pfam09685 446468002039 Tic20-like protein; Region: Tic20; pfam09685 446468002040 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 446468002041 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 446468002042 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 446468002043 chaperone protein DnaJ; Provisional; Region: PRK14278 446468002044 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446468002045 HSP70 interaction site [polypeptide binding]; other site 446468002046 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446468002047 Zn binding sites [ion binding]; other site 446468002048 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446468002049 dimer interface [polypeptide binding]; other site 446468002050 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 446468002051 RNA methyltransferase, RsmE family; Region: TIGR00046 446468002052 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446468002053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468002054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468002055 DNA binding residues [nucleotide binding] 446468002056 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 446468002057 nucleotide binding site/active site [active] 446468002058 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 446468002059 PhoH-like protein; Region: PhoH; pfam02562 446468002060 metal-binding heat shock protein; Provisional; Region: PRK00016 446468002061 Domain of unknown function DUF21; Region: DUF21; pfam01595 446468002062 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 446468002063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446468002064 Transporter associated domain; Region: CorC_HlyC; smart01091 446468002065 GTPase Era; Reviewed; Region: era; PRK00089 446468002066 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 446468002067 G1 box; other site 446468002068 GTP/Mg2+ binding site [chemical binding]; other site 446468002069 Switch I region; other site 446468002070 G2 box; other site 446468002071 Switch II region; other site 446468002072 G3 box; other site 446468002073 G4 box; other site 446468002074 G5 box; other site 446468002075 KH domain; Region: KH_2; pfam07650 446468002076 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468002077 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468002078 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468002079 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 446468002080 allantoinase; Region: allantoinase; TIGR03178 446468002081 active site 446468002082 allantoicase; Provisional; Region: PRK13257 446468002083 Allantoicase repeat; Region: Allantoicase; pfam03561 446468002084 Allantoicase repeat; Region: Allantoicase; pfam03561 446468002085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468002086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468002087 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446468002088 putative dimerization interface [polypeptide binding]; other site 446468002089 xanthine permease; Region: pbuX; TIGR03173 446468002090 urate oxidase; Region: urate_oxi; TIGR03383 446468002091 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446468002092 active site 446468002093 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 446468002094 active site 446468002095 homotetramer interface [polypeptide binding]; other site 446468002096 putative OHCU decarboxylase; Provisional; Region: PRK13798 446468002097 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 446468002098 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 446468002099 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446468002100 glyoxylate carboligase; Provisional; Region: PRK11269 446468002101 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446468002102 PYR/PP interface [polypeptide binding]; other site 446468002103 dimer interface [polypeptide binding]; other site 446468002104 TPP binding site [chemical binding]; other site 446468002105 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446468002106 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446468002107 TPP-binding site [chemical binding]; other site 446468002108 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446468002109 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446468002110 FMN binding site [chemical binding]; other site 446468002111 active site 446468002112 substrate binding site [chemical binding]; other site 446468002113 catalytic residue [active] 446468002114 2-isopropylmalate synthase; Validated; Region: PRK03739 446468002115 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 446468002116 active site 446468002117 catalytic residues [active] 446468002118 metal binding site [ion binding]; metal-binding site 446468002119 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 446468002120 Protein of unknown function DUF2625; Region: DUF2625; cl08177 446468002121 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446468002122 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 446468002123 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 446468002124 Recombination protein O N terminal; Region: RecO_N; pfam11967 446468002125 Recombination protein O C terminal; Region: RecO_C; pfam02565 446468002126 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 446468002127 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446468002128 catalytic residue [active] 446468002129 putative FPP diphosphate binding site; other site 446468002130 putative FPP binding hydrophobic cleft; other site 446468002131 dimer interface [polypeptide binding]; other site 446468002132 putative IPP diphosphate binding site; other site 446468002133 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446468002134 active site 446468002135 catalytic triad [active] 446468002136 oxyanion hole [active] 446468002137 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446468002138 active site 446468002139 catalytic triad [active] 446468002140 oxyanion hole [active] 446468002141 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446468002142 metal binding site 2 [ion binding]; metal-binding site 446468002143 putative DNA binding helix; other site 446468002144 metal binding site 1 [ion binding]; metal-binding site 446468002145 dimer interface [polypeptide binding]; other site 446468002146 structural Zn2+ binding site [ion binding]; other site 446468002147 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446468002148 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468002149 ABC-ATPase subunit interface; other site 446468002150 dimer interface [polypeptide binding]; other site 446468002151 putative PBP binding regions; other site 446468002152 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446468002153 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446468002154 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446468002155 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446468002156 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446468002157 glycyl-tRNA synthetase; Provisional; Region: PRK04173 446468002158 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446468002159 motif 1; other site 446468002160 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 446468002161 dimer interface [polypeptide binding]; other site 446468002162 active site 446468002163 motif 2; other site 446468002164 motif 3; other site 446468002165 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 446468002166 anticodon binding site; other site 446468002167 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468002168 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468002169 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468002170 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 446468002171 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 446468002172 pyruvate phosphate dikinase; Provisional; Region: PRK09279 446468002173 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446468002174 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446468002175 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446468002176 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446468002177 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 446468002178 putative active site [active] 446468002179 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 446468002180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468002181 Zn2+ binding site [ion binding]; other site 446468002182 Mg2+ binding site [ion binding]; other site 446468002183 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 446468002184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468002185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468002186 DNA binding site [nucleotide binding] 446468002187 domain linker motif; other site 446468002188 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 446468002189 ligand binding site [chemical binding]; other site 446468002190 dimerization interface (open form) [polypeptide binding]; other site 446468002191 dimerization interface (closed form) [polypeptide binding]; other site 446468002192 ribulokinase; Provisional; Region: PRK04123 446468002193 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 446468002194 N- and C-terminal domain interface [polypeptide binding]; other site 446468002195 active site 446468002196 MgATP binding site [chemical binding]; other site 446468002197 catalytic site [active] 446468002198 metal binding site [ion binding]; metal-binding site 446468002199 carbohydrate binding site [chemical binding]; other site 446468002200 homodimer interface [polypeptide binding]; other site 446468002201 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 446468002202 intersubunit interface [polypeptide binding]; other site 446468002203 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 446468002204 active site 446468002205 Zn2+ binding site [ion binding]; other site 446468002206 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 446468002207 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 446468002208 hexamer (dimer of trimers) interface [polypeptide binding]; other site 446468002209 trimer interface [polypeptide binding]; other site 446468002210 substrate binding site [chemical binding]; other site 446468002211 Mn binding site [ion binding]; other site 446468002212 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468002213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468002214 dimer interface [polypeptide binding]; other site 446468002215 conserved gate region; other site 446468002216 putative PBP binding loops; other site 446468002217 ABC-ATPase subunit interface; other site 446468002218 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468002219 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468002220 dimer interface [polypeptide binding]; other site 446468002221 conserved gate region; other site 446468002222 putative PBP binding loops; other site 446468002223 ABC-ATPase subunit interface; other site 446468002224 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 446468002225 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 446468002226 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 446468002227 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 446468002228 putative ligand binding site [chemical binding]; other site 446468002229 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446468002230 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468002231 Walker A/P-loop; other site 446468002232 ATP binding site [chemical binding]; other site 446468002233 Q-loop/lid; other site 446468002234 ABC transporter signature motif; other site 446468002235 Walker B; other site 446468002236 D-loop; other site 446468002237 H-loop/switch region; other site 446468002238 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446468002239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468002240 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468002241 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468002242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468002243 TM-ABC transporter signature motif; other site 446468002244 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 446468002245 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446468002246 metal ion-dependent adhesion site (MIDAS); other site 446468002247 DNA primase, catalytic core; Region: dnaG; TIGR01391 446468002248 CHC2 zinc finger; Region: zf-CHC2; pfam01807 446468002249 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 446468002250 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 446468002251 active site 446468002252 metal binding site [ion binding]; metal-binding site 446468002253 interdomain interaction site; other site 446468002254 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 446468002255 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 446468002256 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 446468002257 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446468002258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468002259 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468002260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468002261 DNA binding residues [nucleotide binding] 446468002262 Glyco_18 domain; Region: Glyco_18; smart00636 446468002263 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 446468002264 active site 446468002265 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468002266 FAD binding domain; Region: FAD_binding_4; pfam01565 446468002267 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446468002268 Cysteine-rich domain; Region: CCG; pfam02754 446468002269 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 446468002270 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468002271 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446468002272 RibD C-terminal domain; Region: RibD_C; cl17279 446468002273 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 446468002274 catalytic motif [active] 446468002275 Zn binding site [ion binding]; other site 446468002276 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468002277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468002278 ATP binding site [chemical binding]; other site 446468002279 putative Mg++ binding site [ion binding]; other site 446468002280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468002281 nucleotide binding region [chemical binding]; other site 446468002282 ATP-binding site [chemical binding]; other site 446468002283 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 446468002284 malate dehydrogenase; Provisional; Region: PRK05442 446468002285 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 446468002286 NAD(P) binding site [chemical binding]; other site 446468002287 dimer interface [polypeptide binding]; other site 446468002288 malate binding site [chemical binding]; other site 446468002289 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 446468002290 active site 446468002291 catalytic triad [active] 446468002292 oxyanion hole [active] 446468002293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468002294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468002295 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 446468002296 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 446468002297 active site 446468002298 catalytic site [active] 446468002299 metal binding site [ion binding]; metal-binding site 446468002300 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468002301 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446468002302 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468002303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468002304 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446468002305 active site 446468002306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468002307 Histidine kinase; Region: HisKA_3; pfam07730 446468002308 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468002309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468002311 active site 446468002312 phosphorylation site [posttranslational modification] 446468002313 intermolecular recognition site; other site 446468002314 dimerization interface [polypeptide binding]; other site 446468002315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468002316 DNA binding residues [nucleotide binding] 446468002317 dimerization interface [polypeptide binding]; other site 446468002318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 446468002319 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 446468002320 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446468002321 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468002322 putative DNA binding site [nucleotide binding]; other site 446468002323 putative Zn2+ binding site [ion binding]; other site 446468002324 AsnC family; Region: AsnC_trans_reg; pfam01037 446468002325 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 446468002326 kynureninase; Region: kynureninase; TIGR01814 446468002327 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468002328 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468002329 catalytic residue [active] 446468002330 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468002331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468002332 putative DNA binding site [nucleotide binding]; other site 446468002333 putative Zn2+ binding site [ion binding]; other site 446468002334 AsnC family; Region: AsnC_trans_reg; pfam01037 446468002335 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 446468002336 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446468002337 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446468002338 dimer interface [polypeptide binding]; other site 446468002339 active site 446468002340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468002341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468002342 Walker A/P-loop; other site 446468002343 ATP binding site [chemical binding]; other site 446468002344 Q-loop/lid; other site 446468002345 ABC transporter signature motif; other site 446468002346 Walker B; other site 446468002347 D-loop; other site 446468002348 H-loop/switch region; other site 446468002349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468002350 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 446468002351 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 446468002352 substrate-cofactor binding pocket; other site 446468002353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468002354 catalytic residue [active] 446468002355 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468002356 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446468002357 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 446468002358 PAC2 family; Region: PAC2; pfam09754 446468002359 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 446468002360 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 446468002361 quinone interaction residues [chemical binding]; other site 446468002362 active site 446468002363 catalytic residues [active] 446468002364 FMN binding site [chemical binding]; other site 446468002365 substrate binding site [chemical binding]; other site 446468002366 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 446468002367 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 446468002368 NodB motif; other site 446468002369 active site 446468002370 catalytic site [active] 446468002371 metal binding site [ion binding]; metal-binding site 446468002372 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 446468002373 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 446468002374 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 446468002375 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 446468002376 THF binding site; other site 446468002377 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 446468002378 substrate binding site [chemical binding]; other site 446468002379 THF binding site; other site 446468002380 zinc-binding site [ion binding]; other site 446468002381 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 446468002382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468002383 Walker A/P-loop; other site 446468002384 ATP binding site [chemical binding]; other site 446468002385 Q-loop/lid; other site 446468002386 ABC transporter signature motif; other site 446468002387 Walker B; other site 446468002388 D-loop; other site 446468002389 H-loop/switch region; other site 446468002390 NIL domain; Region: NIL; pfam09383 446468002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468002392 dimer interface [polypeptide binding]; other site 446468002393 conserved gate region; other site 446468002394 ABC-ATPase subunit interface; other site 446468002395 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446468002396 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446468002397 beta-galactosidase; Region: BGL; TIGR03356 446468002398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468002399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468002400 DNA binding site [nucleotide binding] 446468002401 domain linker motif; other site 446468002402 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 446468002403 putative dimerization interface [polypeptide binding]; other site 446468002404 putative ligand binding site [chemical binding]; other site 446468002405 chaperone protein DnaJ; Provisional; Region: PRK14282 446468002406 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446468002407 Nitrate and nitrite sensing; Region: NIT; pfam08376 446468002408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468002410 ATP binding site [chemical binding]; other site 446468002411 Mg2+ binding site [ion binding]; other site 446468002412 G-X-G motif; other site 446468002413 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446468002414 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468002415 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446468002416 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468002417 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 446468002418 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 446468002419 nucleotide binding site/active site [active] 446468002420 HIT family signature motif; other site 446468002421 catalytic residue [active] 446468002422 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446468002423 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 446468002424 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 446468002425 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 446468002426 putative acyl-acceptor binding pocket; other site 446468002427 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446468002428 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 446468002429 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 446468002430 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 446468002431 active site 446468002432 multimer interface [polypeptide binding]; other site 446468002433 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 446468002434 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 446468002435 predicted active site [active] 446468002436 catalytic triad [active] 446468002437 hypothetical protein; Validated; Region: PRK00110 446468002438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468002439 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 446468002440 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446468002441 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 446468002442 tartrate dehydrogenase; Provisional; Region: PRK08194 446468002443 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446468002444 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468002445 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468002446 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468002447 dimerization interface [polypeptide binding]; other site 446468002448 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446468002449 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468002450 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446468002451 nudix motif; other site 446468002452 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446468002453 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 446468002454 active site 446468002455 putative DNA-binding cleft [nucleotide binding]; other site 446468002456 dimer interface [polypeptide binding]; other site 446468002457 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 446468002458 RuvA N terminal domain; Region: RuvA_N; pfam01330 446468002459 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 446468002460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468002461 Walker A motif; other site 446468002462 ATP binding site [chemical binding]; other site 446468002463 Walker B motif; other site 446468002464 arginine finger; other site 446468002465 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 446468002466 Preprotein translocase subunit; Region: YajC; pfam02699 446468002467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468002468 active site 446468002469 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446468002470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468002471 Zn2+ binding site [ion binding]; other site 446468002472 Mg2+ binding site [ion binding]; other site 446468002473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446468002474 synthetase active site [active] 446468002475 NTP binding site [chemical binding]; other site 446468002476 metal binding site [ion binding]; metal-binding site 446468002477 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446468002478 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 446468002479 Domain of unknown function (DUF385); Region: DUF385; cl04387 446468002480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468002481 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468002482 active site 446468002483 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446468002484 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468002485 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 446468002486 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446468002487 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468002488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468002489 catalytic residue [active] 446468002490 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468002491 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468002492 Walker A/P-loop; other site 446468002493 ATP binding site [chemical binding]; other site 446468002494 Q-loop/lid; other site 446468002495 ABC transporter signature motif; other site 446468002496 Walker B; other site 446468002497 D-loop; other site 446468002498 H-loop/switch region; other site 446468002499 FtsX-like permease family; Region: FtsX; pfam02687 446468002500 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468002501 DinB superfamily; Region: DinB_2; pfam12867 446468002502 primosome assembly protein PriA; Provisional; Region: PRK14873 446468002503 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 446468002504 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 446468002505 putative active site [active] 446468002506 substrate binding site [chemical binding]; other site 446468002507 putative cosubstrate binding site; other site 446468002508 catalytic site [active] 446468002509 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446468002510 substrate binding site [chemical binding]; other site 446468002511 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 446468002512 putative RNA binding site [nucleotide binding]; other site 446468002513 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 446468002514 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 446468002515 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 446468002516 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 446468002517 substrate binding site [chemical binding]; other site 446468002518 hexamer interface [polypeptide binding]; other site 446468002519 metal binding site [ion binding]; metal-binding site 446468002520 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 446468002521 active site 446468002522 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 446468002523 Lumazine binding domain; Region: Lum_binding; pfam00677 446468002524 Lumazine binding domain; Region: Lum_binding; pfam00677 446468002525 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 446468002526 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 446468002527 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 446468002528 dimerization interface [polypeptide binding]; other site 446468002529 active site 446468002530 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 446468002531 homopentamer interface [polypeptide binding]; other site 446468002532 active site 446468002533 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446468002534 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 446468002535 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 446468002536 XdhC Rossmann domain; Region: XdhC_C; pfam13478 446468002537 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 446468002538 metal-binding site 446468002539 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 446468002540 active site 446468002541 catalytic residues [active] 446468002542 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446468002543 YCII-related domain; Region: YCII; cl00999 446468002544 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446468002545 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468002546 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468002547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468002548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468002549 active site 446468002550 ATP binding site [chemical binding]; other site 446468002551 substrate binding site [chemical binding]; other site 446468002552 activation loop (A-loop); other site 446468002553 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 446468002554 Uncharacterized conserved protein [Function unknown]; Region: COG2353 446468002555 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468002556 MarR family; Region: MarR_2; pfam12802 446468002557 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 446468002558 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 446468002559 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 446468002560 Tetramer interface [polypeptide binding]; other site 446468002561 active site 446468002562 FMN-binding site [chemical binding]; other site 446468002563 shikimate kinase; Reviewed; Region: aroK; PRK00131 446468002564 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 446468002565 ADP binding site [chemical binding]; other site 446468002566 magnesium binding site [ion binding]; other site 446468002567 putative shikimate binding site; other site 446468002568 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 446468002569 active site 446468002570 dimer interface [polypeptide binding]; other site 446468002571 metal binding site [ion binding]; metal-binding site 446468002572 elongation factor P; Validated; Region: PRK00529 446468002573 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 446468002574 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 446468002575 RNA binding site [nucleotide binding]; other site 446468002576 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 446468002577 RNA binding site [nucleotide binding]; other site 446468002578 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 446468002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468002580 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 446468002581 active site 446468002582 DNA polymerase IV; Validated; Region: PRK02406 446468002583 DNA binding site [nucleotide binding] 446468002584 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446468002585 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446468002586 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446468002587 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446468002588 Protein of unknown function DUF58; Region: DUF58; pfam01882 446468002589 MoxR-like ATPases [General function prediction only]; Region: COG0714 446468002590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468002591 Walker A motif; other site 446468002592 ATP binding site [chemical binding]; other site 446468002593 Walker B motif; other site 446468002594 arginine finger; other site 446468002595 cell division protein MraZ; Reviewed; Region: PRK00326 446468002596 MraZ protein; Region: MraZ; pfam02381 446468002597 MraZ protein; Region: MraZ; pfam02381 446468002598 MraW methylase family; Region: Methyltransf_5; cl17771 446468002599 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 446468002600 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446468002601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446468002602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446468002603 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 446468002604 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 446468002605 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446468002606 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446468002607 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468002608 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446468002609 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446468002610 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 446468002611 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468002612 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 446468002613 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 446468002614 Mg++ binding site [ion binding]; other site 446468002615 putative catalytic motif [active] 446468002616 putative substrate binding site [chemical binding]; other site 446468002617 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 446468002618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468002619 cell division protein FtsW; Region: ftsW; TIGR02614 446468002620 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446468002621 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446468002622 active site 446468002623 homodimer interface [polypeptide binding]; other site 446468002624 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 446468002625 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446468002626 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468002627 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446468002628 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 446468002629 Cell division protein FtsQ; Region: FtsQ; pfam03799 446468002630 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 446468002631 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 446468002632 nucleotide binding site [chemical binding]; other site 446468002633 SulA interaction site; other site 446468002634 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 446468002635 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 446468002636 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 446468002637 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468002638 catalytic residue [active] 446468002639 Protein of unknown function (DUF552); Region: DUF552; pfam04472 446468002640 Predicted integral membrane protein [Function unknown]; Region: COG0762 446468002641 DivIVA domain; Region: DivI1A_domain; TIGR03544 446468002642 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 446468002643 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 446468002644 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 446468002645 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 446468002646 HIGH motif; other site 446468002647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468002648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468002649 active site 446468002650 KMSKS motif; other site 446468002651 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 446468002652 tRNA binding surface [nucleotide binding]; other site 446468002653 anticodon binding site; other site 446468002654 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468002655 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468002656 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 446468002657 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 446468002658 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 446468002659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446468002660 RNA binding surface [nucleotide binding]; other site 446468002661 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 446468002662 active site 446468002663 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468002664 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468002665 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446468002666 putative dimerization interface [polypeptide binding]; other site 446468002667 thiamine pyrophosphate protein; Validated; Region: PRK08199 446468002668 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446468002669 PYR/PP interface [polypeptide binding]; other site 446468002670 dimer interface [polypeptide binding]; other site 446468002671 TPP binding site [chemical binding]; other site 446468002672 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446468002673 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 446468002674 TPP-binding site [chemical binding]; other site 446468002675 AzlC protein; Region: AzlC; cl00570 446468002676 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446468002677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468002678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468002679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468002680 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446468002681 CoenzymeA binding site [chemical binding]; other site 446468002682 subunit interaction site [polypeptide binding]; other site 446468002683 PHB binding site; other site 446468002684 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446468002685 putative catalytic site [active] 446468002686 putative metal binding site [ion binding]; other site 446468002687 putative phosphate binding site [ion binding]; other site 446468002688 Cellulose binding domain; Region: CBM_2; pfam00553 446468002689 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446468002690 metal binding site [ion binding]; metal-binding site 446468002691 active site 446468002692 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 446468002693 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446468002694 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446468002695 NAD synthetase; Provisional; Region: PRK13981 446468002696 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446468002697 multimer interface [polypeptide binding]; other site 446468002698 active site 446468002699 catalytic triad [active] 446468002700 protein interface 1 [polypeptide binding]; other site 446468002701 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446468002702 homodimer interface [polypeptide binding]; other site 446468002703 NAD binding pocket [chemical binding]; other site 446468002704 ATP binding pocket [chemical binding]; other site 446468002705 Mg binding site [ion binding]; other site 446468002706 active-site loop [active] 446468002707 Predicted ATPase [General function prediction only]; Region: COG3899 446468002708 AAA ATPase domain; Region: AAA_16; pfam13191 446468002709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446468002710 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468002711 binding surface 446468002712 TPR motif; other site 446468002713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468002714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468002715 DNA binding residues [nucleotide binding] 446468002716 dimerization interface [polypeptide binding]; other site 446468002717 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 446468002718 active site 446468002719 Ca binding site [ion binding]; other site 446468002720 catalytic site [active] 446468002721 Aamy_C domain; Region: Aamy_C; smart00632 446468002722 Starch binding domain; Region: CBM_20; pfam00686 446468002723 starch-binding site 2 [chemical binding]; other site 446468002724 starch-binding site 1 [chemical binding]; other site 446468002725 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 446468002726 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446468002727 metal binding triad; other site 446468002728 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446468002729 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 446468002730 metal binding triad; other site 446468002731 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 446468002732 glutamine synthetase, type I; Region: GlnA; TIGR00653 446468002733 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 446468002734 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 446468002735 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446468002736 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446468002737 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446468002738 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446468002739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468002740 non-specific DNA binding site [nucleotide binding]; other site 446468002741 salt bridge; other site 446468002742 sequence-specific DNA binding site [nucleotide binding]; other site 446468002743 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 446468002744 lipoyl synthase; Provisional; Region: PRK05481 446468002745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468002746 FeS/SAM binding site; other site 446468002747 lipoate-protein ligase B; Provisional; Region: PRK14345 446468002748 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 446468002749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468002750 NAD(P) binding site [chemical binding]; other site 446468002751 active site 446468002752 Predicted flavoprotein [General function prediction only]; Region: COG0431 446468002753 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468002754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468002755 E3 interaction surface; other site 446468002756 lipoyl attachment site [posttranslational modification]; other site 446468002757 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468002758 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446468002759 E3 interaction surface; other site 446468002760 lipoyl attachment site [posttranslational modification]; other site 446468002761 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446468002762 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 446468002763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468002764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446468002765 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446468002766 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446468002767 interface (dimer of trimers) [polypeptide binding]; other site 446468002768 Substrate-binding/catalytic site; other site 446468002769 Zn-binding sites [ion binding]; other site 446468002770 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 446468002771 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 446468002772 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468002773 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468002774 active site 446468002775 catalytic tetrad [active] 446468002776 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 446468002777 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 446468002778 heat shock protein HtpX; Provisional; Region: PRK02391 446468002779 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 446468002780 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446468002781 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468002782 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446468002783 CoenzymeA binding site [chemical binding]; other site 446468002784 subunit interaction site [polypeptide binding]; other site 446468002785 PHB binding site; other site 446468002786 DNA polymerase I; Provisional; Region: PRK05755 446468002787 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 446468002788 active site 446468002789 putative 5' ssDNA interaction site; other site 446468002790 metal binding site 3; metal-binding site 446468002791 metal binding site 1 [ion binding]; metal-binding site 446468002792 metal binding site 2 [ion binding]; metal-binding site 446468002793 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 446468002794 putative DNA binding site [nucleotide binding]; other site 446468002795 putative metal binding site [ion binding]; other site 446468002796 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 446468002797 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 446468002798 active site 446468002799 DNA binding site [nucleotide binding] 446468002800 catalytic site [active] 446468002801 hypothetical protein; Provisional; Region: PRK09256 446468002802 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 446468002803 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 446468002804 RNA binding site [nucleotide binding]; other site 446468002805 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 446468002806 RNA binding site [nucleotide binding]; other site 446468002807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446468002808 RNA binding site [nucleotide binding]; other site 446468002809 S1 RNA binding domain; Region: S1; pfam00575 446468002810 RNA binding site [nucleotide binding]; other site 446468002811 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 446468002812 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 446468002813 CoA-binding site [chemical binding]; other site 446468002814 ATP-binding [chemical binding]; other site 446468002815 excinuclease ABC subunit B; Provisional; Region: PRK05298 446468002816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468002817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468002818 nucleotide binding region [chemical binding]; other site 446468002819 ATP-binding site [chemical binding]; other site 446468002820 Ultra-violet resistance protein B; Region: UvrB; pfam12344 446468002821 UvrB/uvrC motif; Region: UVR; pfam02151 446468002822 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 446468002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468002824 Coenzyme A binding pocket [chemical binding]; other site 446468002825 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 446468002826 active site 446468002827 catalytic residues [active] 446468002828 metal binding site [ion binding]; metal-binding site 446468002829 CTP synthetase; Validated; Region: pyrG; PRK05380 446468002830 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 446468002831 Catalytic site [active] 446468002832 active site 446468002833 UTP binding site [chemical binding]; other site 446468002834 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 446468002835 active site 446468002836 putative oxyanion hole; other site 446468002837 catalytic triad [active] 446468002838 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446468002839 dimer interface [polypeptide binding]; other site 446468002840 active site 446468002841 ADP-ribose binding site [chemical binding]; other site 446468002842 nudix motif; other site 446468002843 metal binding site [ion binding]; metal-binding site 446468002844 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468002845 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 446468002846 active site 446468002847 DNA binding site [nucleotide binding] 446468002848 Int/Topo IB signature motif; other site 446468002849 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446468002850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446468002851 P-loop; other site 446468002852 Magnesium ion binding site [ion binding]; other site 446468002853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446468002854 Magnesium ion binding site [ion binding]; other site 446468002855 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 446468002856 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 446468002857 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 446468002858 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 446468002859 active site 446468002860 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 446468002861 homotrimer interaction site [polypeptide binding]; other site 446468002862 active site 446468002863 prephenate dehydrogenase; Validated; Region: PRK06545 446468002864 prephenate dehydrogenase; Validated; Region: PRK08507 446468002865 cytidylate kinase; Provisional; Region: cmk; PRK00023 446468002866 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 446468002867 CMP-binding site; other site 446468002868 The sites determining sugar specificity; other site 446468002869 GTP-binding protein Der; Reviewed; Region: PRK03003 446468002870 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 446468002871 G1 box; other site 446468002872 GTP/Mg2+ binding site [chemical binding]; other site 446468002873 Switch I region; other site 446468002874 G2 box; other site 446468002875 Switch II region; other site 446468002876 G3 box; other site 446468002877 G4 box; other site 446468002878 G5 box; other site 446468002879 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 446468002880 G1 box; other site 446468002881 GTP/Mg2+ binding site [chemical binding]; other site 446468002882 Switch I region; other site 446468002883 G2 box; other site 446468002884 G3 box; other site 446468002885 Switch II region; other site 446468002886 G4 box; other site 446468002887 G5 box; other site 446468002888 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468002889 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468002890 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468002891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468002892 putative substrate translocation pore; other site 446468002893 Predicted membrane protein [Function unknown]; Region: COG2311 446468002894 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468002895 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 446468002896 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 446468002897 Uncharacterized conserved protein [Function unknown]; Region: COG1683 446468002898 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446468002899 RibD C-terminal domain; Region: RibD_C; cl17279 446468002900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468002901 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 446468002902 substrate binding site [chemical binding]; other site 446468002903 active site 446468002904 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 446468002905 Na binding site [ion binding]; other site 446468002906 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468002907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468002908 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468002909 NAD(P) binding site [chemical binding]; other site 446468002910 active site 446468002911 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446468002912 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468002913 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468002914 DNA binding residues [nucleotide binding] 446468002915 SnoaL-like domain; Region: SnoaL_2; pfam12680 446468002916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 446468002917 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446468002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446468002919 aconitate hydratase; Validated; Region: PRK09277 446468002920 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446468002921 substrate binding site [chemical binding]; other site 446468002922 ligand binding site [chemical binding]; other site 446468002923 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 446468002924 substrate binding site [chemical binding]; other site 446468002925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468002926 DNA-binding site [nucleotide binding]; DNA binding site 446468002927 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468002928 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468002929 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446468002930 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446468002931 substrate binding pocket [chemical binding]; other site 446468002932 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468002933 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446468002934 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446468002935 FMN binding site [chemical binding]; other site 446468002936 active site 446468002937 substrate binding site [chemical binding]; other site 446468002938 catalytic residue [active] 446468002939 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446468002940 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468002941 DNA binding residues [nucleotide binding] 446468002942 putative dimer interface [polypeptide binding]; other site 446468002943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468002944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468002945 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468002946 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 446468002947 Ca binding site [ion binding]; other site 446468002948 Ca binding site (active) [ion binding]; other site 446468002949 ligand binding site [chemical binding]; other site 446468002950 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 446468002951 Methane oxygenase PmoA; Region: PmoA; pfam14100 446468002952 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468002953 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468002954 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446468002955 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468002956 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468002957 DNA binding site [nucleotide binding] 446468002958 domain linker motif; other site 446468002959 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468002960 ligand binding site [chemical binding]; other site 446468002961 dimerization interface [polypeptide binding]; other site 446468002962 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446468002963 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 446468002964 active site 446468002965 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468002966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468002967 putative substrate translocation pore; other site 446468002968 allantoate amidohydrolase; Reviewed; Region: PRK09290 446468002969 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 446468002970 active site 446468002971 metal binding site [ion binding]; metal-binding site 446468002972 dimer interface [polypeptide binding]; other site 446468002973 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468002974 TspO/MBR family; Region: TspO_MBR; pfam03073 446468002975 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468002976 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468002977 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468002978 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446468002979 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446468002980 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446468002981 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446468002982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468002983 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446468002984 metal binding site 2 [ion binding]; metal-binding site 446468002985 putative DNA binding helix; other site 446468002986 metal binding site 1 [ion binding]; metal-binding site 446468002987 dimer interface [polypeptide binding]; other site 446468002988 structural Zn2+ binding site [ion binding]; other site 446468002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468002990 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 446468002991 NAD(P) binding site [chemical binding]; other site 446468002992 active site 446468002993 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446468002994 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446468002995 Isochorismatase family; Region: Isochorismatase; pfam00857 446468002996 catalytic triad [active] 446468002997 conserved cis-peptide bond; other site 446468002998 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 446468002999 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468003000 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468003001 active site 446468003002 CoA binding site [chemical binding]; other site 446468003003 AMP binding site [chemical binding]; other site 446468003004 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 446468003005 Condensation domain; Region: Condensation; pfam00668 446468003006 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468003007 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468003008 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468003009 acyl-activating enzyme (AAE) consensus motif; other site 446468003010 AMP binding site [chemical binding]; other site 446468003011 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468003012 Condensation domain; Region: Condensation; pfam00668 446468003013 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468003014 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468003015 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468003016 acyl-activating enzyme (AAE) consensus motif; other site 446468003017 AMP binding site [chemical binding]; other site 446468003018 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468003019 Condensation domain; Region: Condensation; pfam00668 446468003020 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468003021 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468003022 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468003023 acyl-activating enzyme (AAE) consensus motif; other site 446468003024 AMP binding site [chemical binding]; other site 446468003025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468003026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468003027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468003028 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 446468003029 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 446468003030 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 446468003031 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468003032 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446468003033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003034 S-adenosylmethionine binding site [chemical binding]; other site 446468003035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468003036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468003038 Walker A/P-loop; other site 446468003039 ATP binding site [chemical binding]; other site 446468003040 Q-loop/lid; other site 446468003041 ABC transporter signature motif; other site 446468003042 Walker B; other site 446468003043 D-loop; other site 446468003044 H-loop/switch region; other site 446468003045 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468003046 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468003047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003048 Walker A/P-loop; other site 446468003049 ATP binding site [chemical binding]; other site 446468003050 Q-loop/lid; other site 446468003051 ABC transporter signature motif; other site 446468003052 Walker B; other site 446468003053 D-loop; other site 446468003054 H-loop/switch region; other site 446468003055 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468003056 Cytochrome P450; Region: p450; cl12078 446468003057 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 446468003058 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 446468003059 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446468003060 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 446468003061 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468003062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468003063 ABC-ATPase subunit interface; other site 446468003064 putative PBP binding loops; other site 446468003065 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446468003066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003067 Walker A/P-loop; other site 446468003068 ATP binding site [chemical binding]; other site 446468003069 Q-loop/lid; other site 446468003070 ABC transporter signature motif; other site 446468003071 Walker B; other site 446468003072 D-loop; other site 446468003073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468003074 Walker A/P-loop; other site 446468003075 ATP binding site [chemical binding]; other site 446468003076 Q-loop/lid; other site 446468003077 ABC transporter signature motif; other site 446468003078 Walker B; other site 446468003079 D-loop; other site 446468003080 H-loop/switch region; other site 446468003081 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 446468003082 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468003083 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468003084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468003085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468003086 ABC-ATPase subunit interface; other site 446468003087 putative PBP binding loops; other site 446468003088 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468003089 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468003090 Walker A/P-loop; other site 446468003091 ATP binding site [chemical binding]; other site 446468003092 Q-loop/lid; other site 446468003093 ABC transporter signature motif; other site 446468003094 Walker B; other site 446468003095 D-loop; other site 446468003096 H-loop/switch region; other site 446468003097 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468003098 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446468003099 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468003100 Walker A/P-loop; other site 446468003101 ATP binding site [chemical binding]; other site 446468003102 Q-loop/lid; other site 446468003103 ABC transporter signature motif; other site 446468003104 Walker B; other site 446468003105 D-loop; other site 446468003106 H-loop/switch region; other site 446468003107 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468003108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003109 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468003110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468003111 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446468003112 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 446468003113 active site pocket [active] 446468003114 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 446468003115 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 446468003116 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 446468003117 active site 446468003118 Zn binding site [ion binding]; other site 446468003119 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 446468003120 lipoyl attachment site [posttranslational modification]; other site 446468003121 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468003122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468003123 substrate binding site [chemical binding]; other site 446468003124 oxyanion hole (OAH) forming residues; other site 446468003125 trimer interface [polypeptide binding]; other site 446468003126 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468003127 Zn2+ binding site [ion binding]; other site 446468003128 Mg2+ binding site [ion binding]; other site 446468003129 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 446468003130 synthetase active site [active] 446468003131 NTP binding site [chemical binding]; other site 446468003132 metal binding site [ion binding]; metal-binding site 446468003133 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 446468003134 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446468003135 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 446468003136 active site 446468003137 FMN binding site [chemical binding]; other site 446468003138 substrate binding site [chemical binding]; other site 446468003139 homotetramer interface [polypeptide binding]; other site 446468003140 catalytic residue [active] 446468003141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468003142 putative DNA binding site [nucleotide binding]; other site 446468003143 dimerization interface [polypeptide binding]; other site 446468003144 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446468003145 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 446468003146 Predicted membrane protein [Function unknown]; Region: COG2311 446468003147 Protein of unknown function (DUF418); Region: DUF418; cl12135 446468003148 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 446468003149 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468003150 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003151 putative substrate translocation pore; other site 446468003152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468003155 dimerization interface [polypeptide binding]; other site 446468003156 putative DNA binding site [nucleotide binding]; other site 446468003157 putative Zn2+ binding site [ion binding]; other site 446468003158 Cupin domain; Region: Cupin_2; pfam07883 446468003159 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 446468003160 IucA / IucC family; Region: IucA_IucC; pfam04183 446468003161 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 446468003162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 446468003163 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 446468003164 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 446468003165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468003166 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 446468003167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468003168 catalytic residue [active] 446468003169 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 446468003170 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468003171 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468003172 Walker A/P-loop; other site 446468003173 ATP binding site [chemical binding]; other site 446468003174 Q-loop/lid; other site 446468003175 ABC transporter signature motif; other site 446468003176 Walker B; other site 446468003177 D-loop; other site 446468003178 H-loop/switch region; other site 446468003179 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468003180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468003181 active site 446468003182 phosphorylation site [posttranslational modification] 446468003183 intermolecular recognition site; other site 446468003184 dimerization interface [polypeptide binding]; other site 446468003185 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468003186 DNA binding residues [nucleotide binding] 446468003187 dimerization interface [polypeptide binding]; other site 446468003188 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446468003189 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468003190 Methyltransferase domain; Region: Methyltransf_12; pfam08242 446468003191 S-adenosylmethionine binding site [chemical binding]; other site 446468003192 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 446468003193 active site 446468003194 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468003195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468003196 dimer interface [polypeptide binding]; other site 446468003197 conserved gate region; other site 446468003198 putative PBP binding loops; other site 446468003199 ABC-ATPase subunit interface; other site 446468003200 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 446468003201 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468003202 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446468003203 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446468003204 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446468003205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468003206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468003207 DNA binding site [nucleotide binding] 446468003208 domain linker motif; other site 446468003209 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468003210 dimerization interface [polypeptide binding]; other site 446468003211 ligand binding site [chemical binding]; other site 446468003212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468003213 salt bridge; other site 446468003214 non-specific DNA binding site [nucleotide binding]; other site 446468003215 sequence-specific DNA binding site [nucleotide binding]; other site 446468003216 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468003217 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468003218 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 446468003219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468003221 putative substrate translocation pore; other site 446468003222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003224 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 446468003225 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468003226 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 446468003227 acyl-activating enzyme (AAE) consensus motif; other site 446468003228 acyl-activating enzyme (AAE) consensus motif; other site 446468003229 putative AMP binding site [chemical binding]; other site 446468003230 putative active site [active] 446468003231 putative CoA binding site [chemical binding]; other site 446468003232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468003233 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 446468003234 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446468003235 active site 446468003236 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 446468003237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 446468003238 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446468003239 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446468003240 Predicted acetyltransferase [General function prediction only]; Region: COG2388 446468003241 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446468003242 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446468003243 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468003244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468003245 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468003246 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446468003247 Isochorismatase family; Region: Isochorismatase; pfam00857 446468003248 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 446468003249 catalytic triad [active] 446468003250 dimer interface [polypeptide binding]; other site 446468003251 conserved cis-peptide bond; other site 446468003252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468003253 Coenzyme A binding pocket [chemical binding]; other site 446468003254 FOG: CBS domain [General function prediction only]; Region: COG0517 446468003255 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446468003256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446468003257 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 446468003258 Winged helix-turn helix; Region: HTH_29; pfam13551 446468003259 Integrase core domain; Region: rve; pfam00665 446468003260 Integrase core domain; Region: rve_3; pfam13683 446468003261 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 446468003262 BON domain; Region: BON; pfam04972 446468003263 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 446468003264 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 446468003265 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 446468003266 Universal stress protein family; Region: Usp; pfam00582 446468003267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468003268 Ligand Binding Site [chemical binding]; other site 446468003269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468003270 Ligand Binding Site [chemical binding]; other site 446468003271 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446468003272 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446468003273 dimer interface [polypeptide binding]; other site 446468003274 putative functional site; other site 446468003275 putative MPT binding site; other site 446468003276 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003278 putative substrate translocation pore; other site 446468003279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468003282 Coenzyme A binding pocket [chemical binding]; other site 446468003283 mannose-6-phosphate isomerase; Region: PLN02288 446468003284 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446468003285 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446468003286 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446468003287 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468003288 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468003289 active site 446468003290 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003291 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468003292 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446468003293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003295 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 446468003296 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468003297 Walker A/P-loop; other site 446468003298 ATP binding site [chemical binding]; other site 446468003299 Q-loop/lid; other site 446468003300 ABC transporter signature motif; other site 446468003301 Walker B; other site 446468003302 D-loop; other site 446468003303 H-loop/switch region; other site 446468003304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468003305 Histidine kinase; Region: HisKA_3; pfam07730 446468003306 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468003307 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468003308 phosphorylation site [posttranslational modification] 446468003309 intermolecular recognition site; other site 446468003310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468003311 dimerization interface [polypeptide binding]; other site 446468003312 DNA binding residues [nucleotide binding] 446468003313 Domain of unknown function (DUF385); Region: DUF385; pfam04075 446468003314 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 446468003315 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446468003316 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446468003317 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446468003318 acyl-activating enzyme (AAE) consensus motif; other site 446468003319 putative AMP binding site [chemical binding]; other site 446468003320 putative active site [active] 446468003321 putative CoA binding site [chemical binding]; other site 446468003322 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468003323 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468003324 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468003325 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446468003326 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 446468003327 hypothetical protein; Validated; Region: PRK06201 446468003328 DctM-like transporters; Region: DctM; pfam06808 446468003329 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 446468003330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468003331 dimerization interface [polypeptide binding]; other site 446468003332 putative DNA binding site [nucleotide binding]; other site 446468003333 putative Zn2+ binding site [ion binding]; other site 446468003334 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468003335 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468003336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468003337 ATP binding site [chemical binding]; other site 446468003338 Mg2+ binding site [ion binding]; other site 446468003339 G-X-G motif; other site 446468003340 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 446468003341 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468003342 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446468003343 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468003344 G2 box; other site 446468003345 Switch I region; other site 446468003346 G3 box; other site 446468003347 Switch II region; other site 446468003348 G4 box; other site 446468003349 G5 box; other site 446468003350 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468003351 oxidoreductase; Provisional; Region: PRK06196 446468003352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468003353 NAD(P) binding site [chemical binding]; other site 446468003354 active site 446468003355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468003356 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468003357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003358 O-methyltransferase; Region: Methyltransf_2; pfam00891 446468003359 NAD-dependent deacetylase; Provisional; Region: PRK05333 446468003360 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 446468003361 pyruvate carboxylase; Reviewed; Region: PRK12999 446468003362 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468003363 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468003364 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446468003365 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 446468003366 active site 446468003367 catalytic residues [active] 446468003368 metal binding site [ion binding]; metal-binding site 446468003369 homodimer binding site [polypeptide binding]; other site 446468003370 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446468003371 carboxyltransferase (CT) interaction site; other site 446468003372 biotinylation site [posttranslational modification]; other site 446468003373 Protein of unknown function, DUF488; Region: DUF488; pfam04343 446468003374 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 446468003375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003376 Hemerythrin-like domain; Region: Hr-like; cd12108 446468003377 Fe binding site [ion binding]; other site 446468003378 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 446468003379 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 446468003380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468003381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468003382 DNA binding site [nucleotide binding] 446468003383 domain linker motif; other site 446468003384 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468003385 ligand binding site [chemical binding]; other site 446468003386 dimerization interface [polypeptide binding]; other site 446468003387 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446468003388 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446468003389 metal binding site [ion binding]; metal-binding site 446468003390 substrate binding pocket [chemical binding]; other site 446468003391 PQQ-like domain; Region: PQQ_2; pfam13360 446468003392 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 446468003393 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468003394 intersubunit interface [polypeptide binding]; other site 446468003395 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446468003396 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468003397 ABC-ATPase subunit interface; other site 446468003398 dimer interface [polypeptide binding]; other site 446468003399 putative PBP binding regions; other site 446468003400 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468003401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003402 Walker A/P-loop; other site 446468003403 ATP binding site [chemical binding]; other site 446468003404 Q-loop/lid; other site 446468003405 ABC transporter signature motif; other site 446468003406 Walker B; other site 446468003407 D-loop; other site 446468003408 H-loop/switch region; other site 446468003409 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 446468003410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003411 putative substrate translocation pore; other site 446468003412 potassium/proton antiporter; Reviewed; Region: PRK05326 446468003413 TrkA-C domain; Region: TrkA_C; pfam02080 446468003414 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468003415 Ligand Binding Site [chemical binding]; other site 446468003416 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468003417 Ligand Binding Site [chemical binding]; other site 446468003418 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 446468003419 putative hydrophobic ligand binding site [chemical binding]; other site 446468003420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468003421 dimerization interface [polypeptide binding]; other site 446468003422 putative DNA binding site [nucleotide binding]; other site 446468003423 putative Zn2+ binding site [ion binding]; other site 446468003424 prephenate dehydrogenase; Validated; Region: PRK06545 446468003425 prephenate dehydrogenase; Validated; Region: PRK08507 446468003426 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 446468003427 homotrimer interaction site [polypeptide binding]; other site 446468003428 active site 446468003429 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446468003430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468003432 putative substrate translocation pore; other site 446468003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468003436 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446468003437 NAD(P) binding site [chemical binding]; other site 446468003438 active site 446468003439 Cupin domain; Region: Cupin_2; pfam07883 446468003440 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 446468003441 active site 446468003442 cosubstrate binding site; other site 446468003443 substrate binding site [chemical binding]; other site 446468003444 catalytic site [active] 446468003445 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 446468003446 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 446468003447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468003448 active site 446468003449 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468003450 FAD binding domain; Region: FAD_binding_4; pfam01565 446468003451 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cl10037 446468003452 homotrimer interaction site [polypeptide binding]; other site 446468003453 active site 446468003454 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 446468003455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003457 active site 446468003458 catalytic tetrad [active] 446468003459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468003460 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446468003461 active site 446468003462 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468003463 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 446468003464 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468003465 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446468003466 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468003467 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446468003468 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468003469 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 446468003470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468003471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468003472 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 446468003473 putative dimerization interface [polypeptide binding]; other site 446468003474 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 446468003475 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446468003476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468003477 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468003478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468003479 DNA binding residues [nucleotide binding] 446468003480 Low molecular weight phosphatase family; Region: LMWPc; cl00105 446468003481 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 446468003482 transcription termination factor Rho; Provisional; Region: PRK12678 446468003483 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 446468003484 Protein of unknown function (DUF690); Region: DUF690; cl04939 446468003485 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446468003486 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 446468003487 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446468003488 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468003489 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446468003490 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468003491 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468003492 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446468003493 active site 446468003494 catalytic residues [active] 446468003495 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 446468003496 active site 446468003497 conformational flexibility of ligand binding pocket; other site 446468003498 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468003499 ADP-ribosylating toxin turn-turn motif; other site 446468003500 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 446468003501 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468003502 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468003503 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 446468003504 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446468003505 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446468003506 Walker A motif; other site 446468003507 ATP binding site [chemical binding]; other site 446468003508 Walker B motif; other site 446468003509 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 446468003510 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446468003511 ligand binding site [chemical binding]; other site 446468003512 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 446468003513 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 446468003514 putative dimer interface [polypeptide binding]; other site 446468003515 N-terminal domain interface [polypeptide binding]; other site 446468003516 putative substrate binding pocket (H-site) [chemical binding]; other site 446468003517 hypothetical protein; Provisional; Region: PRK06185 446468003518 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468003519 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468003520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003521 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446468003522 dihydropteroate synthase; Region: DHPS; TIGR01496 446468003523 substrate binding pocket [chemical binding]; other site 446468003524 dimer interface [polypeptide binding]; other site 446468003525 inhibitor binding site; inhibition site 446468003526 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 446468003527 active site 446468003528 metal binding site [ion binding]; metal-binding site 446468003529 hypothetical protein; Provisional; Region: PRK14059 446468003530 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446468003531 Protease prsW family; Region: PrsW-protease; pfam13367 446468003532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468003533 PQQ-like domain; Region: PQQ_2; pfam13360 446468003534 SCP-2 sterol transfer family; Region: SCP2; pfam02036 446468003535 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446468003536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468003537 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446468003538 dimerization interface [polypeptide binding]; other site 446468003539 substrate binding pocket [chemical binding]; other site 446468003540 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468003541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468003542 substrate binding site [chemical binding]; other site 446468003543 oxyanion hole (OAH) forming residues; other site 446468003544 trimer interface [polypeptide binding]; other site 446468003545 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446468003546 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468003547 acyl-activating enzyme (AAE) consensus motif; other site 446468003548 AMP binding site [chemical binding]; other site 446468003549 active site 446468003550 CoA binding site [chemical binding]; other site 446468003551 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468003552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003553 putative substrate translocation pore; other site 446468003554 PAP2 superfamily; Region: PAP2; pfam01569 446468003555 active site 446468003556 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 446468003557 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446468003558 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446468003559 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 446468003560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468003561 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 446468003562 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 446468003563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003564 S-adenosylmethionine binding site [chemical binding]; other site 446468003565 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 446468003566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003567 S-adenosylmethionine binding site [chemical binding]; other site 446468003568 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 446468003569 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446468003570 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 446468003571 NAD binding site [chemical binding]; other site 446468003572 substrate binding site [chemical binding]; other site 446468003573 catalytic Zn binding site [ion binding]; other site 446468003574 structural Zn binding site [ion binding]; other site 446468003575 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 446468003576 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003577 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468003578 Walker A/P-loop; other site 446468003579 ATP binding site [chemical binding]; other site 446468003580 Q-loop/lid; other site 446468003581 ABC transporter signature motif; other site 446468003582 Walker B; other site 446468003583 D-loop; other site 446468003584 H-loop/switch region; other site 446468003585 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468003586 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468003587 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468003588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003589 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 446468003590 active site 446468003591 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446468003592 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468003593 RNA polymerase factor sigma-70; Validated; Region: PRK08241 446468003594 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468003595 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468003596 DNA binding residues [nucleotide binding] 446468003597 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 446468003598 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468003599 DNA-binding site [nucleotide binding]; DNA binding site 446468003600 RNA-binding motif; other site 446468003601 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446468003602 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468003603 ATP binding site [chemical binding]; other site 446468003604 Mg++ binding site [ion binding]; other site 446468003605 motif III; other site 446468003606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468003607 nucleotide binding region [chemical binding]; other site 446468003608 ATP-binding site [chemical binding]; other site 446468003609 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468003610 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468003611 DNA binding residues [nucleotide binding] 446468003612 dimer interface [polypeptide binding]; other site 446468003613 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468003614 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468003615 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 446468003616 Uncharacterized conserved protein [Function unknown]; Region: COG1262 446468003617 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468003618 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468003619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003620 S-adenosylmethionine binding site [chemical binding]; other site 446468003621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003623 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446468003624 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468003625 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446468003626 catalytic site [active] 446468003627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468003628 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446468003629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003631 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 446468003632 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446468003633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003634 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468003635 Walker A/P-loop; other site 446468003636 ATP binding site [chemical binding]; other site 446468003637 Q-loop/lid; other site 446468003638 ABC transporter signature motif; other site 446468003639 Walker B; other site 446468003640 D-loop; other site 446468003641 H-loop/switch region; other site 446468003642 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446468003643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468003644 Walker A/P-loop; other site 446468003645 ATP binding site [chemical binding]; other site 446468003646 Q-loop/lid; other site 446468003647 ABC transporter signature motif; other site 446468003648 Walker B; other site 446468003649 D-loop; other site 446468003650 H-loop/switch region; other site 446468003651 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446468003652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003653 S-adenosylmethionine binding site [chemical binding]; other site 446468003654 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 446468003655 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 446468003656 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 446468003657 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 446468003658 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 446468003659 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 446468003660 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 446468003661 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 446468003662 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003664 S-adenosylmethionine binding site [chemical binding]; other site 446468003665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468003666 sequence-specific DNA binding site [nucleotide binding]; other site 446468003667 salt bridge; other site 446468003668 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468003669 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 446468003670 sequence-specific DNA binding site [nucleotide binding]; other site 446468003671 salt bridge; other site 446468003672 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468003673 Protein kinase domain; Region: Pkinase; pfam00069 446468003674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468003675 active site 446468003676 ATP binding site [chemical binding]; other site 446468003677 substrate binding site [chemical binding]; other site 446468003678 activation loop (A-loop); other site 446468003679 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468003680 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468003681 active site 446468003682 ATP binding site [chemical binding]; other site 446468003683 substrate binding site [chemical binding]; other site 446468003684 activation loop (A-loop); other site 446468003685 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468003686 MarR family; Region: MarR; pfam01047 446468003687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446468003688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468003689 NAD(P) binding site [chemical binding]; other site 446468003690 active site 446468003691 Homeodomain-like domain; Region: HTH_23; cl17451 446468003692 Beta/Gamma crystallin; Region: Crystall; cl02528 446468003693 PQQ-like domain; Region: PQQ_2; pfam13360 446468003694 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446468003695 PQQ-like domain; Region: PQQ_2; pfam13360 446468003696 active site 446468003697 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 446468003698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003699 S-adenosylmethionine binding site [chemical binding]; other site 446468003700 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446468003701 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468003702 Transposase; Region: DEDD_Tnp_IS110; pfam01548 446468003703 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468003704 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468003705 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003706 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003707 active site 446468003708 catalytic tetrad [active] 446468003709 Predicted transcriptional regulators [Transcription]; Region: COG1733 446468003710 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446468003711 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 446468003712 substrate binding pocket [chemical binding]; other site 446468003713 substrate-Mg2+ binding site; other site 446468003714 aspartate-rich region 1; other site 446468003715 aspartate-rich region 2; other site 446468003716 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 446468003717 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 446468003718 catalytic residue [active] 446468003719 putative FPP diphosphate binding site; other site 446468003720 putative FPP binding hydrophobic cleft; other site 446468003721 dimer interface [polypeptide binding]; other site 446468003722 putative IPP diphosphate binding site; other site 446468003723 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 446468003724 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446468003725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446468003726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468003727 Phosphotransferase enzyme family; Region: APH; pfam01636 446468003728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468003729 active site 446468003730 substrate binding site [chemical binding]; other site 446468003731 ATP binding site [chemical binding]; other site 446468003732 short chain dehydrogenase; Provisional; Region: PRK06523 446468003733 classical (c) SDRs; Region: SDR_c; cd05233 446468003734 NAD(P) binding site [chemical binding]; other site 446468003735 active site 446468003736 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003738 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 446468003739 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446468003740 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 446468003741 putative sugar binding site [chemical binding]; other site 446468003742 catalytic residues [active] 446468003743 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 446468003744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468003745 S-adenosylmethionine binding site [chemical binding]; other site 446468003746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468003747 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468003748 sequence-specific DNA binding site [nucleotide binding]; other site 446468003749 salt bridge; other site 446468003750 short chain dehydrogenase; Provisional; Region: PRK05854 446468003751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468003752 NAD(P) binding site [chemical binding]; other site 446468003753 active site 446468003754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003755 putative substrate translocation pore; other site 446468003756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468003757 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446468003758 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 446468003759 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468003760 NAD binding site [chemical binding]; other site 446468003761 catalytic residues [active] 446468003762 BCCT family transporter; Region: BCCT; pfam02028 446468003763 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468003764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468003765 non-specific DNA binding site [nucleotide binding]; other site 446468003766 salt bridge; other site 446468003767 sequence-specific DNA binding site [nucleotide binding]; other site 446468003768 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446468003769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003770 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468003771 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 446468003772 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446468003773 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 446468003774 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446468003775 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446468003776 active site 446468003777 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468003778 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468003779 DNA binding residues [nucleotide binding] 446468003780 dimer interface [polypeptide binding]; other site 446468003781 Sodium Bile acid symporter family; Region: SBF; cl17470 446468003782 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446468003783 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446468003784 Thioredoxin; Region: Thioredoxin_4; pfam13462 446468003785 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446468003786 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 446468003787 Penicillinase repressor; Region: Pencillinase_R; pfam03965 446468003788 Thioredoxin; Region: Thioredoxin_4; pfam13462 446468003789 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446468003790 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446468003791 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446468003792 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446468003793 iron-sulfur cluster [ion binding]; other site 446468003794 [2Fe-2S] cluster binding site [ion binding]; other site 446468003795 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446468003796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468003797 Coenzyme A binding pocket [chemical binding]; other site 446468003798 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446468003799 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 446468003800 dimerization interface [polypeptide binding]; other site 446468003801 Cytochrome P450; Region: p450; cl12078 446468003802 Predicted acyl esterases [General function prediction only]; Region: COG2936 446468003803 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 446468003804 urea carboxylase; Region: urea_carbox; TIGR02712 446468003805 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003806 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003807 active site 446468003808 catalytic tetrad [active] 446468003809 classical (c) SDRs; Region: SDR_c; cd05233 446468003810 NAD(P) binding site [chemical binding]; other site 446468003811 active site 446468003812 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468003813 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 446468003814 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 446468003815 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 446468003816 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446468003817 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 446468003818 Clp amino terminal domain; Region: Clp_N; pfam02861 446468003819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468003820 Walker A motif; other site 446468003821 ATP binding site [chemical binding]; other site 446468003822 Walker B motif; other site 446468003823 arginine finger; other site 446468003824 UvrB/uvrC motif; Region: UVR; pfam02151 446468003825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468003826 Walker A motif; other site 446468003827 ATP binding site [chemical binding]; other site 446468003828 Walker B motif; other site 446468003829 arginine finger; other site 446468003830 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446468003831 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468003832 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468003833 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446468003834 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468003835 Predicted ATPase [General function prediction only]; Region: COG3903 446468003836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 446468003837 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 446468003838 ligand binding site [chemical binding]; other site 446468003839 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446468003840 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468003841 Walker A/P-loop; other site 446468003842 ATP binding site [chemical binding]; other site 446468003843 Q-loop/lid; other site 446468003844 ABC transporter signature motif; other site 446468003845 Walker B; other site 446468003846 D-loop; other site 446468003847 H-loop/switch region; other site 446468003848 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446468003849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468003850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468003851 TM-ABC transporter signature motif; other site 446468003852 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446468003853 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 446468003854 putative NAD(P) binding site [chemical binding]; other site 446468003855 catalytic Zn binding site [ion binding]; other site 446468003856 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 446468003857 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468003858 classical (c) SDRs; Region: SDR_c; cd05233 446468003859 NAD(P) binding site [chemical binding]; other site 446468003860 active site 446468003861 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468003862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468003863 DNA-binding site [nucleotide binding]; DNA binding site 446468003864 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468003865 galactonate dehydratase; Provisional; Region: PRK14017 446468003866 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 446468003867 metal binding site [ion binding]; metal-binding site 446468003868 substrate binding pocket [chemical binding]; other site 446468003869 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446468003870 Strictosidine synthase; Region: Str_synth; pfam03088 446468003871 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446468003872 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468003873 substrate binding site [chemical binding]; other site 446468003874 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 446468003875 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446468003876 active site 446468003877 intersubunit interface [polypeptide binding]; other site 446468003878 catalytic residue [active] 446468003879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003881 active site 446468003882 catalytic tetrad [active] 446468003883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468003884 D-xylulose kinase; Region: XylB; TIGR01312 446468003885 nucleotide binding site [chemical binding]; other site 446468003886 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 446468003887 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 446468003888 active site residue [active] 446468003889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468003890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468003891 DNA binding site [nucleotide binding] 446468003892 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 446468003893 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 446468003894 putative pectinesterase; Region: PLN02432; cl01911 446468003895 Pectinesterase; Region: Pectinesterase; pfam01095 446468003896 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 446468003897 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 446468003898 dimerization interface [polypeptide binding]; other site 446468003899 DPS ferroxidase diiron center [ion binding]; other site 446468003900 ion pore; other site 446468003901 sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; Region: ATPase-IIC_X-K; TIGR01106 446468003902 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468003903 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003904 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003905 active site 446468003906 catalytic tetrad [active] 446468003907 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468003908 homotrimer interaction site [polypeptide binding]; other site 446468003909 putative active site [active] 446468003910 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 446468003911 EamA-like transporter family; Region: EamA; pfam00892 446468003912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003914 NAD-dependent deacetylase; Provisional; Region: PRK00481 446468003915 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 446468003916 NAD+ binding site [chemical binding]; other site 446468003917 substrate binding site [chemical binding]; other site 446468003918 Zn binding site [ion binding]; other site 446468003919 NACHT domain; Region: NACHT; pfam05729 446468003920 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 446468003921 ligand binding site [chemical binding]; other site 446468003922 active site 446468003923 UGI interface [polypeptide binding]; other site 446468003924 catalytic site [active] 446468003925 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 446468003926 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468003927 putative NAD(P) binding site [chemical binding]; other site 446468003928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003930 WHG domain; Region: WHG; pfam13305 446468003931 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446468003932 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446468003933 Predicted membrane protein [Function unknown]; Region: COG2364 446468003934 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 446468003935 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446468003936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468003937 DNA-binding site [nucleotide binding]; DNA binding site 446468003938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468003939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468003940 homodimer interface [polypeptide binding]; other site 446468003941 catalytic residue [active] 446468003942 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 446468003943 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468003944 PGAP1-like protein; Region: PGAP1; pfam07819 446468003945 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 446468003946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468003947 FeS/SAM binding site; other site 446468003948 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 446468003949 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 446468003950 hypothetical protein; Reviewed; Region: PRK09588 446468003951 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 446468003952 active site 446468003953 Polycystin cation channel protein; Provisional; Region: PLN03223 446468003954 Dodecin; Region: Dodecin; pfam07311 446468003955 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446468003956 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446468003957 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446468003958 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446468003959 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 446468003960 putative DNA binding site [nucleotide binding]; other site 446468003961 putative Zn2+ binding site [ion binding]; other site 446468003962 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 446468003963 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468003964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468003965 DNA-binding site [nucleotide binding]; DNA binding site 446468003966 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468003967 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 446468003968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468003969 putative substrate translocation pore; other site 446468003970 CAAX protease self-immunity; Region: Abi; pfam02517 446468003971 Transposase IS200 like; Region: Y1_Tnp; pfam01797 446468003972 Probable transposase; Region: OrfB_IS605; pfam01385 446468003973 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468003974 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 446468003975 isocitrate lyase; Provisional; Region: PRK15063 446468003976 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446468003977 tetramer interface [polypeptide binding]; other site 446468003978 active site 446468003979 Mg2+/Mn2+ binding site [ion binding]; other site 446468003980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468003981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468003982 non-specific DNA binding site [nucleotide binding]; other site 446468003983 salt bridge; other site 446468003984 sequence-specific DNA binding site [nucleotide binding]; other site 446468003985 Domain of unknown function (DUF955); Region: DUF955; pfam06114 446468003986 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468003987 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468003988 active site 446468003989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468003990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468003991 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446468003992 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 446468003993 DNA binding residues [nucleotide binding] 446468003994 putative dimer interface [polypeptide binding]; other site 446468003995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468003996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468003997 active site 446468003998 catalytic tetrad [active] 446468003999 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446468004000 Part of AAA domain; Region: AAA_19; pfam13245 446468004001 anthranilate synthase; Provisional; Region: PRK13566 446468004002 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446468004003 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446468004004 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446468004005 glutamine binding [chemical binding]; other site 446468004006 catalytic triad [active] 446468004007 Thymidylate synthase complementing protein; Region: Thy1; pfam02511 446468004008 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468004009 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446468004010 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 446468004011 metal binding site [ion binding]; metal-binding site 446468004012 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 446468004013 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468004014 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468004015 EF-hand domain pair; Region: EF_hand_5; pfam13499 446468004016 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 446468004017 Ca2+ binding site [ion binding]; other site 446468004018 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 446468004019 Ca2+ binding site [ion binding]; other site 446468004020 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446468004021 EF-hand domain pair; Region: EF_hand_5; pfam13499 446468004022 Ca2+ binding site [ion binding]; other site 446468004023 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446468004024 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446468004025 inhibitor-cofactor binding pocket; inhibition site 446468004026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004027 catalytic residue [active] 446468004028 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 446468004029 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446468004030 inhibitor-cofactor binding pocket; inhibition site 446468004031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004032 catalytic residue [active] 446468004033 UbiA prenyltransferase family; Region: UbiA; pfam01040 446468004034 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 446468004035 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446468004036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004037 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468004038 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446468004039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468004040 acyl-activating enzyme (AAE) consensus motif; other site 446468004041 AMP binding site [chemical binding]; other site 446468004042 active site 446468004043 CoA binding site [chemical binding]; other site 446468004044 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468004045 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446468004046 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468004047 acyl-activating enzyme (AAE) consensus motif; other site 446468004048 AMP binding site [chemical binding]; other site 446468004049 active site 446468004050 CoA binding site [chemical binding]; other site 446468004051 hypothetical protein; Provisional; Region: PRK08317 446468004052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004053 S-adenosylmethionine binding site [chemical binding]; other site 446468004054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468004055 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446468004056 hydrophobic ligand binding site; other site 446468004057 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446468004058 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446468004059 putative sugar binding sites [chemical binding]; other site 446468004060 Q-X-W motif; other site 446468004061 Chorismate mutase type II; Region: CM_2; cl00693 446468004062 PRC-barrel domain; Region: PRC; pfam05239 446468004063 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 446468004064 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446468004065 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004066 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 446468004067 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 446468004068 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 446468004069 active site 446468004070 Substrate binding site; other site 446468004071 Mg++ binding site; other site 446468004072 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 446468004073 putative trimer interface [polypeptide binding]; other site 446468004074 putative CoA binding site [chemical binding]; other site 446468004075 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 446468004076 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 446468004077 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 446468004078 Double zinc ribbon; Region: DZR; pfam12773 446468004079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446468004080 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446468004081 phosphopeptide binding site; other site 446468004082 Bifunctional nuclease; Region: DNase-RNase; pfam02577 446468004083 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468004084 DNA binding residues [nucleotide binding] 446468004085 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468004086 glycine dehydrogenase; Provisional; Region: PRK05367 446468004087 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446468004088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004089 tetramer interface [polypeptide binding]; other site 446468004090 catalytic residue [active] 446468004091 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 446468004092 tetramer interface [polypeptide binding]; other site 446468004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004094 catalytic residue [active] 446468004095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468004096 binding surface 446468004097 TPR motif; other site 446468004098 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468004099 Uncharacterized conserved protein [Function unknown]; Region: COG2966 446468004100 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 446468004101 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 446468004102 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468004103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468004104 active site 446468004105 phosphorylation site [posttranslational modification] 446468004106 intermolecular recognition site; other site 446468004107 dimerization interface [polypeptide binding]; other site 446468004108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468004109 DNA binding residues [nucleotide binding] 446468004110 dimerization interface [polypeptide binding]; other site 446468004111 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446468004112 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 446468004113 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446468004114 active site 446468004115 putative substrate binding region [chemical binding]; other site 446468004116 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468004117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004118 salt bridge; other site 446468004119 non-specific DNA binding site [nucleotide binding]; other site 446468004120 sequence-specific DNA binding site [nucleotide binding]; other site 446468004121 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468004122 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468004123 nucleotide binding site [chemical binding]; other site 446468004124 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 446468004125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468004126 proteasome ATPase; Region: pup_AAA; TIGR03689 446468004127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468004128 Walker A motif; other site 446468004129 ATP binding site [chemical binding]; other site 446468004130 Walker B motif; other site 446468004131 arginine finger; other site 446468004132 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446468004133 Domain of unknown function DUF21; Region: DUF21; pfam01595 446468004134 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446468004135 Transporter associated domain; Region: CorC_HlyC; smart01091 446468004136 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 446468004137 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446468004138 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468004139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004140 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468004141 putative substrate translocation pore; other site 446468004142 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 446468004143 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 446468004144 active site 446468004145 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446468004146 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 446468004147 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 446468004148 Pup-like protein; Region: Pup; pfam05639 446468004149 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 446468004150 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 446468004151 active site 446468004152 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 446468004153 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446468004154 active site 446468004155 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 446468004156 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446468004157 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 446468004158 active site 446468004159 cosubstrate binding site; other site 446468004160 substrate binding site [chemical binding]; other site 446468004161 catalytic site [active] 446468004162 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 446468004163 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 446468004164 Predicted transcriptional regulator [Transcription]; Region: COG2378 446468004165 WYL domain; Region: WYL; pfam13280 446468004166 Predicted transcriptional regulator [Transcription]; Region: COG2378 446468004167 WYL domain; Region: WYL; pfam13280 446468004168 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 446468004169 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 446468004170 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 446468004171 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468004172 SpoOM protein; Region: Spo0M; pfam07070 446468004173 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446468004174 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468004175 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468004176 active site 446468004177 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 446468004178 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 446468004179 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446468004180 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446468004181 K+-transporting ATPase, c chain; Region: KdpC; cl00944 446468004182 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446468004183 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 446468004184 Ligand Binding Site [chemical binding]; other site 446468004185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468004186 ATP binding site [chemical binding]; other site 446468004187 Mg2+ binding site [ion binding]; other site 446468004188 G-X-G motif; other site 446468004189 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468004190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468004191 active site 446468004192 phosphorylation site [posttranslational modification] 446468004193 intermolecular recognition site; other site 446468004194 dimerization interface [polypeptide binding]; other site 446468004195 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468004196 DNA binding site [nucleotide binding] 446468004197 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 446468004198 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 446468004199 diacylglycerol kinase; Reviewed; Region: PRK11914 446468004200 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446468004201 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468004202 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468004203 ATP binding site [chemical binding]; other site 446468004204 putative Mg++ binding site [ion binding]; other site 446468004205 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468004206 nucleotide binding region [chemical binding]; other site 446468004207 ATP-binding site [chemical binding]; other site 446468004208 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 446468004209 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 446468004210 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 446468004211 tetramerization interface [polypeptide binding]; other site 446468004212 active site 446468004213 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446468004214 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 446468004215 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 446468004216 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468004217 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468004218 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004219 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468004220 Walker A/P-loop; other site 446468004221 ATP binding site [chemical binding]; other site 446468004222 Q-loop/lid; other site 446468004223 ABC transporter signature motif; other site 446468004224 Walker B; other site 446468004225 D-loop; other site 446468004226 H-loop/switch region; other site 446468004227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004228 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468004229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004230 S-adenosylmethionine binding site [chemical binding]; other site 446468004231 Cupin superfamily protein; Region: Cupin_4; pfam08007 446468004232 Cupin-like domain; Region: Cupin_8; pfam13621 446468004233 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 446468004234 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446468004235 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468004236 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 446468004237 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 446468004238 Walker A/P-loop; other site 446468004239 ATP binding site [chemical binding]; other site 446468004240 Q-loop/lid; other site 446468004241 ABC transporter signature motif; other site 446468004242 Walker B; other site 446468004243 D-loop; other site 446468004244 H-loop/switch region; other site 446468004245 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 446468004246 putative active site [active] 446468004247 catalytic triad [active] 446468004248 putative dimer interface [polypeptide binding]; other site 446468004249 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 446468004250 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446468004251 nucleoside/Zn binding site; other site 446468004252 dimer interface [polypeptide binding]; other site 446468004253 catalytic motif [active] 446468004254 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 446468004255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446468004256 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446468004257 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 446468004258 NRDE protein; Region: NRDE; cl01315 446468004259 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 446468004260 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 446468004261 active site 446468004262 catalytic residues [active] 446468004263 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446468004264 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446468004265 putative sugar binding sites [chemical binding]; other site 446468004266 Q-X-W motif; other site 446468004267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004268 non-specific DNA binding site [nucleotide binding]; other site 446468004269 salt bridge; other site 446468004270 sequence-specific DNA binding site [nucleotide binding]; other site 446468004271 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468004272 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 446468004273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468004274 active site 446468004275 HIGH motif; other site 446468004276 nucleotide binding site [chemical binding]; other site 446468004277 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468004278 active site 446468004279 KMSKS motif; other site 446468004280 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446468004281 tRNA binding surface [nucleotide binding]; other site 446468004282 anticodon binding site; other site 446468004283 Domain of unknown function (DUF385); Region: DUF385; cl04387 446468004284 PAC2 family; Region: PAC2; pfam09754 446468004285 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 446468004286 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 446468004287 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 446468004288 substrate binding pocket [chemical binding]; other site 446468004289 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 446468004290 B12 binding site [chemical binding]; other site 446468004291 cobalt ligand [ion binding]; other site 446468004292 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 446468004293 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 446468004294 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446468004295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468004296 motif II; other site 446468004297 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468004298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468004299 dimer interface [polypeptide binding]; other site 446468004300 conserved gate region; other site 446468004301 putative PBP binding loops; other site 446468004302 ABC-ATPase subunit interface; other site 446468004303 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446468004304 peptide binding site [polypeptide binding]; other site 446468004305 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468004306 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468004307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468004308 dimer interface [polypeptide binding]; other site 446468004309 conserved gate region; other site 446468004310 putative PBP binding loops; other site 446468004311 ABC-ATPase subunit interface; other site 446468004312 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446468004313 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468004314 Walker A/P-loop; other site 446468004315 ATP binding site [chemical binding]; other site 446468004316 Q-loop/lid; other site 446468004317 ABC transporter signature motif; other site 446468004318 Walker B; other site 446468004319 D-loop; other site 446468004320 H-loop/switch region; other site 446468004321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468004322 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468004323 Walker A/P-loop; other site 446468004324 ATP binding site [chemical binding]; other site 446468004325 Q-loop/lid; other site 446468004326 ABC transporter signature motif; other site 446468004327 Walker B; other site 446468004328 D-loop; other site 446468004329 H-loop/switch region; other site 446468004330 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468004331 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 446468004332 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 446468004333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468004334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004335 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 446468004336 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446468004337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004338 putative substrate translocation pore; other site 446468004339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468004340 MarR family; Region: MarR; pfam01047 446468004341 MarR family; Region: MarR_2; cl17246 446468004342 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 446468004343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004344 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468004345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004346 non-specific DNA binding site [nucleotide binding]; other site 446468004347 salt bridge; other site 446468004348 sequence-specific DNA binding site [nucleotide binding]; other site 446468004349 Cupin domain; Region: Cupin_2; pfam07883 446468004350 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 446468004351 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 446468004352 putative active site [active] 446468004353 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 446468004354 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 446468004355 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 446468004356 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468004357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468004358 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 446468004359 active site 446468004360 motif I; other site 446468004361 motif II; other site 446468004362 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 446468004363 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 446468004364 putative active site [active] 446468004365 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446468004366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468004367 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446468004368 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446468004369 putative ADP-binding pocket [chemical binding]; other site 446468004370 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 446468004371 dimer interface [polypeptide binding]; other site 446468004372 active site 446468004373 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446468004374 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468004375 active site 446468004376 HIGH motif; other site 446468004377 nucleotide binding site [chemical binding]; other site 446468004378 classical (c) SDRs; Region: SDR_c; cd05233 446468004379 NAD(P) binding site [chemical binding]; other site 446468004380 active site 446468004381 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468004382 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 446468004383 NAD binding site [chemical binding]; other site 446468004384 putative substrate binding site 2 [chemical binding]; other site 446468004385 putative substrate binding site 1 [chemical binding]; other site 446468004386 active site 446468004387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468004388 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446468004389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468004390 active site 446468004391 DinB superfamily; Region: DinB_2; pfam12867 446468004392 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 446468004393 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 446468004394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468004395 active site 446468004396 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 446468004397 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 446468004398 Dehydroquinase class II; Region: DHquinase_II; pfam01220 446468004399 active site 446468004400 trimer interface [polypeptide binding]; other site 446468004401 dimer interface [polypeptide binding]; other site 446468004402 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 446468004403 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468004404 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 446468004405 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 446468004406 putative molybdopterin cofactor binding site [chemical binding]; other site 446468004407 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 446468004408 putative molybdopterin cofactor binding site; other site 446468004409 PAS domain; Region: PAS; smart00091 446468004410 PAS domain; Region: PAS_9; pfam13426 446468004411 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468004412 GAF domain; Region: GAF; pfam01590 446468004413 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468004414 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 446468004415 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446468004416 NAD binding site [chemical binding]; other site 446468004417 catalytic Zn binding site [ion binding]; other site 446468004418 structural Zn binding site [ion binding]; other site 446468004419 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 446468004420 active site 446468004421 catalytic residues [active] 446468004422 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446468004423 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468004424 siderophore binding site; other site 446468004425 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446468004426 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446468004427 FAD binding pocket [chemical binding]; other site 446468004428 FAD binding motif [chemical binding]; other site 446468004429 phosphate binding motif [ion binding]; other site 446468004430 NAD binding pocket [chemical binding]; other site 446468004431 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468004432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004433 Walker A/P-loop; other site 446468004434 ATP binding site [chemical binding]; other site 446468004435 Q-loop/lid; other site 446468004436 ABC transporter signature motif; other site 446468004437 Walker B; other site 446468004438 D-loop; other site 446468004439 H-loop/switch region; other site 446468004440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468004441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468004442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004443 Walker A/P-loop; other site 446468004444 ATP binding site [chemical binding]; other site 446468004445 Q-loop/lid; other site 446468004446 ABC transporter signature motif; other site 446468004447 Walker B; other site 446468004448 D-loop; other site 446468004449 H-loop/switch region; other site 446468004450 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 446468004451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004452 Walker A/P-loop; other site 446468004453 ATP binding site [chemical binding]; other site 446468004454 Q-loop/lid; other site 446468004455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004456 ABC transporter signature motif; other site 446468004457 Walker B; other site 446468004458 D-loop; other site 446468004459 H-loop/switch region; other site 446468004460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004461 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 446468004462 Walker A/P-loop; other site 446468004463 ATP binding site [chemical binding]; other site 446468004464 Q-loop/lid; other site 446468004465 ABC transporter signature motif; other site 446468004466 Walker B; other site 446468004467 D-loop; other site 446468004468 H-loop/switch region; other site 446468004469 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446468004470 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446468004471 FAD binding pocket [chemical binding]; other site 446468004472 FAD binding motif [chemical binding]; other site 446468004473 phosphate binding motif [ion binding]; other site 446468004474 NAD binding pocket [chemical binding]; other site 446468004475 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446468004476 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468004477 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468004478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468004479 DNA-binding site [nucleotide binding]; DNA binding site 446468004480 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446468004481 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468004482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004483 homodimer interface [polypeptide binding]; other site 446468004484 catalytic residue [active] 446468004485 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446468004486 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446468004487 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468004488 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468004489 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446468004490 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446468004491 carboxyltransferase (CT) interaction site; other site 446468004492 biotinylation site [posttranslational modification]; other site 446468004493 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 446468004494 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446468004495 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446468004496 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446468004497 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468004498 intersubunit interface [polypeptide binding]; other site 446468004499 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468004500 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468004501 ABC-ATPase subunit interface; other site 446468004502 dimer interface [polypeptide binding]; other site 446468004503 putative PBP binding regions; other site 446468004504 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468004505 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468004506 Walker A/P-loop; other site 446468004507 ATP binding site [chemical binding]; other site 446468004508 Q-loop/lid; other site 446468004509 ABC transporter signature motif; other site 446468004510 Walker B; other site 446468004511 D-loop; other site 446468004512 H-loop/switch region; other site 446468004513 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 446468004514 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 446468004515 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 446468004516 precorrin 6A synthase; Provisional; Region: PRK08284 446468004517 active site 446468004518 homodimer interface [polypeptide binding]; other site 446468004519 SAM binding site [chemical binding]; other site 446468004520 Cobyric acid synthase [Coenzyme metabolism]; Region: CobQ; COG1492 446468004521 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468004522 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446468004523 catalytic triad [active] 446468004524 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 446468004525 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468004526 putative active site [active] 446468004527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468004528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004529 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446468004530 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 446468004531 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468004532 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 446468004533 catalytic triad [active] 446468004534 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 446468004535 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 446468004536 Walker A motif; other site 446468004537 homodimer interface [polypeptide binding]; other site 446468004538 ATP binding site [chemical binding]; other site 446468004539 hydroxycobalamin binding site [chemical binding]; other site 446468004540 Walker B motif; other site 446468004541 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 446468004542 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 446468004543 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 446468004544 metal ion-dependent adhesion site (MIDAS); other site 446468004545 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 446468004546 active site 446468004547 putative homodimer interface [polypeptide binding]; other site 446468004548 SAM binding site [chemical binding]; other site 446468004549 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 446468004550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004551 S-adenosylmethionine binding site [chemical binding]; other site 446468004552 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 446468004553 active site 446468004554 SAM binding site [chemical binding]; other site 446468004555 homodimer interface [polypeptide binding]; other site 446468004556 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 446468004557 active site 446468004558 SAM binding site [chemical binding]; other site 446468004559 homodimer interface [polypeptide binding]; other site 446468004560 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 446468004561 active site 446468004562 SAM binding site [chemical binding]; other site 446468004563 homodimer interface [polypeptide binding]; other site 446468004564 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 446468004565 Precorrin-8X methylmutase; Region: CbiC; pfam02570 446468004566 precorrin-3B synthase; Region: CobG; TIGR02435 446468004567 Right handed beta helix region; Region: Beta_helix; pfam13229 446468004568 Right handed beta helix region; Region: Beta_helix; pfam13229 446468004569 stage V sporulation protein K; Region: spore_V_K; TIGR02881 446468004570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468004571 Walker A motif; other site 446468004572 ATP binding site [chemical binding]; other site 446468004573 Walker B motif; other site 446468004574 arginine finger; other site 446468004575 stage V sporulation protein K; Region: spore_V_K; TIGR02881 446468004576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468004577 Walker A motif; other site 446468004578 ATP binding site [chemical binding]; other site 446468004579 Walker B motif; other site 446468004580 arginine finger; other site 446468004581 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 446468004582 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 446468004583 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 446468004584 homodimer interface [polypeptide binding]; other site 446468004585 substrate-cofactor binding pocket; other site 446468004586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004587 catalytic residue [active] 446468004588 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468004589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468004590 DNA-binding site [nucleotide binding]; DNA binding site 446468004591 FCD domain; Region: FCD; pfam07729 446468004592 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 446468004593 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446468004594 Ligand Binding Site [chemical binding]; other site 446468004595 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 446468004596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468004597 dimer interface [polypeptide binding]; other site 446468004598 phosphorylation site [posttranslational modification] 446468004599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468004600 Mg2+ binding site [ion binding]; other site 446468004601 G-X-G motif; other site 446468004602 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 446468004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468004604 active site 446468004605 phosphorylation site [posttranslational modification] 446468004606 intermolecular recognition site; other site 446468004607 dimerization interface [polypeptide binding]; other site 446468004608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468004609 DNA binding site [nucleotide binding] 446468004610 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 446468004611 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 446468004612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004613 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446468004614 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004615 Sulphur transport; Region: Sulf_transp; pfam04143 446468004616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468004617 Ligand Binding Site [chemical binding]; other site 446468004618 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468004619 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468004620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004621 S-adenosylmethionine binding site [chemical binding]; other site 446468004622 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468004623 Coenzyme A binding pocket [chemical binding]; other site 446468004624 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446468004625 Ligand Binding Site [chemical binding]; other site 446468004626 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468004627 DNA binding residues [nucleotide binding] 446468004628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004629 sequence-specific DNA binding site [nucleotide binding]; other site 446468004630 salt bridge; other site 446468004631 Flavoprotein; Region: Flavoprotein; pfam02441 446468004632 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 446468004633 putative active site; other site 446468004634 signature motif; other site 446468004635 putative triphosphate binding site [ion binding]; other site 446468004636 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468004637 DNA binding residues [nucleotide binding] 446468004638 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468004639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468004640 Mg2+ binding site [ion binding]; other site 446468004641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004642 sequence-specific DNA binding site [nucleotide binding]; other site 446468004643 salt bridge; other site 446468004644 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468004645 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468004646 Cupin domain; Region: Cupin_2; pfam07883 446468004647 Helix-turn-helix domain; Region: HTH_18; pfam12833 446468004648 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468004649 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446468004650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468004651 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 446468004652 Phosphotransferase enzyme family; Region: APH; pfam01636 446468004653 putative active site [active] 446468004654 putative substrate binding site [chemical binding]; other site 446468004655 ATP binding site [chemical binding]; other site 446468004656 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468004657 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468004658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468004659 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446468004660 active site 446468004661 substrate binding site [chemical binding]; other site 446468004662 trimer interface [polypeptide binding]; other site 446468004663 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446468004664 CoA binding site [chemical binding]; other site 446468004665 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446468004666 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 446468004667 metal binding site [ion binding]; metal-binding site 446468004668 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 446468004669 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468004670 homotrimer interaction site [polypeptide binding]; other site 446468004671 putative active site [active] 446468004672 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 446468004673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468004674 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468004675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004676 putative substrate translocation pore; other site 446468004677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468004678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468004679 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468004680 dimerization interface [polypeptide binding]; other site 446468004681 Histidine kinase; Region: HisKA_3; pfam07730 446468004682 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468004683 Predicted membrane protein [Function unknown]; Region: COG2311 446468004684 Protein of unknown function (DUF418); Region: DUF418; cl12135 446468004685 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468004686 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468004687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468004688 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446468004689 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468004690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446468004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004693 putative substrate translocation pore; other site 446468004694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468004695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468004696 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446468004697 dimerization interface [polypeptide binding]; other site 446468004698 substrate binding pocket [chemical binding]; other site 446468004699 Domain of unknown function (DUF427); Region: DUF427; pfam04248 446468004700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004701 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468004702 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468004703 Walker A/P-loop; other site 446468004704 ATP binding site [chemical binding]; other site 446468004705 Q-loop/lid; other site 446468004706 ABC transporter signature motif; other site 446468004707 Walker B; other site 446468004708 D-loop; other site 446468004709 H-loop/switch region; other site 446468004710 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 446468004711 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468004712 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468004713 Walker A/P-loop; other site 446468004714 ATP binding site [chemical binding]; other site 446468004715 Q-loop/lid; other site 446468004716 ABC transporter signature motif; other site 446468004717 Walker B; other site 446468004718 D-loop; other site 446468004719 H-loop/switch region; other site 446468004720 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468004721 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004722 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 446468004723 active site pocket [active] 446468004724 oxyanion hole [active] 446468004725 catalytic triad [active] 446468004726 active site nucleophile [active] 446468004727 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468004728 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468004729 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468004730 OPT oligopeptide transporter protein; Region: OPT; cl14607 446468004731 OPT oligopeptide transporter protein; Region: OPT; cl14607 446468004732 AroM protein; Region: AroM; cl17601 446468004733 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446468004734 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 446468004735 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446468004736 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 446468004737 putative NAD(P) binding site [chemical binding]; other site 446468004738 putative substrate binding site [chemical binding]; other site 446468004739 catalytic Zn binding site [ion binding]; other site 446468004740 structural Zn binding site [ion binding]; other site 446468004741 dimer interface [polypeptide binding]; other site 446468004742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004743 salt bridge; other site 446468004744 non-specific DNA binding site [nucleotide binding]; other site 446468004745 sequence-specific DNA binding site [nucleotide binding]; other site 446468004746 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 446468004747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468004748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468004749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468004750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468004751 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446468004752 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 446468004753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468004754 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468004755 Uncharacterized conserved protein [Function unknown]; Region: COG2128 446468004756 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 446468004757 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 446468004758 Strictosidine synthase; Region: Str_synth; pfam03088 446468004759 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446468004760 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446468004761 MarR family; Region: MarR; pfam01047 446468004762 SnoaL-like domain; Region: SnoaL_2; pfam12680 446468004763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004764 sequence-specific DNA binding site [nucleotide binding]; other site 446468004765 salt bridge; other site 446468004766 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 446468004767 nucleotide binding site/active site [active] 446468004768 HIT family signature motif; other site 446468004769 catalytic residue [active] 446468004770 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468004771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004772 putative substrate translocation pore; other site 446468004773 tetracycline repressor protein TetR; Provisional; Region: PRK13756 446468004774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004775 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468004776 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446468004777 putative homotetramer interface [polypeptide binding]; other site 446468004778 putative homodimer interface [polypeptide binding]; other site 446468004779 putative allosteric switch controlling residues; other site 446468004780 putative metal binding site [ion binding]; other site 446468004781 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446468004782 active site residue [active] 446468004783 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446468004784 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446468004785 active site residue [active] 446468004786 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446468004787 active site residue [active] 446468004788 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446468004789 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 446468004790 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 446468004791 active site 446468004792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468004793 sequence-specific DNA binding site [nucleotide binding]; other site 446468004794 salt bridge; other site 446468004795 Cupin domain; Region: Cupin_2; pfam07883 446468004796 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446468004797 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468004798 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468004799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468004800 dimerization interface [polypeptide binding]; other site 446468004801 putative DNA binding site [nucleotide binding]; other site 446468004802 putative Zn2+ binding site [ion binding]; other site 446468004803 Thioredoxin; Region: Thioredoxin_4; pfam13462 446468004804 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 446468004805 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 446468004806 putative active site [active] 446468004807 redox center [active] 446468004808 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468004809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468004810 NAD(P) binding site [chemical binding]; other site 446468004811 active site 446468004812 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446468004813 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446468004814 Ligand binding site; other site 446468004815 Putative Catalytic site; other site 446468004816 DXD motif; other site 446468004817 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 446468004818 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468004819 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 446468004820 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 446468004821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468004822 putative substrate translocation pore; other site 446468004823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468004824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468004825 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 446468004826 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468004827 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 446468004828 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 446468004829 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 446468004830 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468004831 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 446468004832 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446468004833 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 446468004834 E3 Ubiquitin ligase; Region: GIDE; pfam12483 446468004835 enoyl-CoA hydratase; Provisional; Region: PRK06494 446468004836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468004837 substrate binding site [chemical binding]; other site 446468004838 oxyanion hole (OAH) forming residues; other site 446468004839 trimer interface [polypeptide binding]; other site 446468004840 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468004841 substrate binding site [chemical binding]; other site 446468004842 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468004843 oxyanion hole (OAH) forming residues; other site 446468004844 trimer interface [polypeptide binding]; other site 446468004845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 446468004846 dimerization interface [polypeptide binding]; other site 446468004847 DNA binding residues [nucleotide binding] 446468004848 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468004849 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468004850 trimer interface [polypeptide binding]; other site 446468004851 oxyanion hole (OAH) forming residues; other site 446468004852 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 446468004853 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 446468004854 malonyl-CoA binding site [chemical binding]; other site 446468004855 dimer interface [polypeptide binding]; other site 446468004856 active site 446468004857 product binding site; other site 446468004858 Condensation domain; Region: Condensation; pfam00668 446468004859 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004860 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468004861 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004862 acyl-activating enzyme (AAE) consensus motif; other site 446468004863 AMP binding site [chemical binding]; other site 446468004864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004865 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 446468004866 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468004867 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004868 acyl-activating enzyme (AAE) consensus motif; other site 446468004869 AMP binding site [chemical binding]; other site 446468004870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004871 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446468004872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468004873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468004874 homodimer interface [polypeptide binding]; other site 446468004875 catalytic residue [active] 446468004876 MbtH-like protein; Region: MbtH; cl01279 446468004877 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468004878 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004879 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468004880 acyl-activating enzyme (AAE) consensus motif; other site 446468004881 AMP binding site [chemical binding]; other site 446468004882 Condensation domain; Region: Condensation; pfam00668 446468004883 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004884 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468004885 acyl-activating enzyme (AAE) consensus motif; other site 446468004886 AMP binding site [chemical binding]; other site 446468004887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004888 Condensation domain; Region: Condensation; pfam00668 446468004889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004890 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468004891 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004892 acyl-activating enzyme (AAE) consensus motif; other site 446468004893 AMP binding site [chemical binding]; other site 446468004894 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004895 Condensation domain; Region: Condensation; pfam00668 446468004896 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004897 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468004898 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468004899 acyl-activating enzyme (AAE) consensus motif; other site 446468004900 AMP binding site [chemical binding]; other site 446468004901 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004902 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468004903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004904 S-adenosylmethionine binding site [chemical binding]; other site 446468004905 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468004906 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468004907 DNA binding residues [nucleotide binding] 446468004908 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 446468004909 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 446468004910 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 446468004911 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 446468004912 acyl-activating enzyme (AAE) consensus motif; other site 446468004913 active site 446468004914 AMP binding site [chemical binding]; other site 446468004915 substrate binding site [chemical binding]; other site 446468004916 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446468004917 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468004918 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446468004919 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 446468004920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004921 S-adenosylmethionine binding site [chemical binding]; other site 446468004922 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446468004923 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468004924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468004925 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468004926 Walker A/P-loop; other site 446468004927 ATP binding site [chemical binding]; other site 446468004928 Q-loop/lid; other site 446468004929 ABC transporter signature motif; other site 446468004930 Walker B; other site 446468004931 D-loop; other site 446468004932 H-loop/switch region; other site 446468004933 SnoaL-like domain; Region: SnoaL_3; pfam13474 446468004934 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446468004935 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446468004936 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 446468004937 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468004938 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 446468004939 Condensation domain; Region: Condensation; pfam00668 446468004940 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004941 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468004942 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468004943 acyl-activating enzyme (AAE) consensus motif; other site 446468004944 AMP binding site [chemical binding]; other site 446468004945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468004946 S-adenosylmethionine binding site [chemical binding]; other site 446468004947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468004948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004949 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 446468004950 Condensation domain; Region: Condensation; pfam00668 446468004951 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004952 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468004953 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468004954 acyl-activating enzyme (AAE) consensus motif; other site 446468004955 AMP binding site [chemical binding]; other site 446468004956 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004957 Condensation domain; Region: Condensation; pfam00668 446468004958 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468004959 Nonribosomal peptide synthase; Region: NRPS; pfam08415 446468004960 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 446468004961 acyl-activating enzyme (AAE) consensus motif; other site 446468004962 AMP binding site [chemical binding]; other site 446468004963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468004964 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 446468004965 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446468004966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468004967 acyl-activating enzyme (AAE) consensus motif; other site 446468004968 AMP binding site [chemical binding]; other site 446468004969 active site 446468004970 CoA binding site [chemical binding]; other site 446468004971 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446468004972 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446468004973 glutamine binding [chemical binding]; other site 446468004974 catalytic triad [active] 446468004975 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 446468004976 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446468004977 chorismate binding enzyme; Region: Chorismate_bind; cl10555 446468004978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468004979 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468004980 DNA binding residues [nucleotide binding] 446468004981 dimerization interface [polypeptide binding]; other site 446468004982 Predicted transcriptional regulators [Transcription]; Region: COG1733 446468004983 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446468004984 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468004985 homotrimer interaction site [polypeptide binding]; other site 446468004986 putative active site [active] 446468004987 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446468004988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468004989 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468004990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468004991 DNA binding residues [nucleotide binding] 446468004992 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468004993 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468004994 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 446468004995 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 446468004996 hypothetical protein; Provisional; Region: PRK06771 446468004997 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 446468004998 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 446468004999 Cu(I) binding site [ion binding]; other site 446468005000 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446468005001 Protein of unknown function (DUF461); Region: DUF461; pfam04314 446468005002 Probable transposase; Region: OrfB_IS605; pfam01385 446468005003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468005004 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468005005 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 446468005006 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 446468005007 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446468005008 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 446468005009 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 446468005010 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 446468005011 short chain dehydrogenase; Provisional; Region: PRK06701 446468005012 NAD binding site [chemical binding]; other site 446468005013 metal binding site [ion binding]; metal-binding site 446468005014 active site 446468005015 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468005016 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468005017 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 446468005018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005020 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446468005021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468005023 putative DNA binding site [nucleotide binding]; other site 446468005024 putative Zn2+ binding site [ion binding]; other site 446468005025 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 446468005026 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446468005027 Soluble P-type ATPase [General function prediction only]; Region: COG4087 446468005028 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 446468005029 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 446468005030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468005031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446468005032 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446468005033 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 446468005034 active site 446468005035 substrate binding site [chemical binding]; other site 446468005036 trimer interface [polypeptide binding]; other site 446468005037 CoA binding site [chemical binding]; other site 446468005038 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446468005039 NB-ARC domain; Region: NB-ARC; pfam00931 446468005040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468005041 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468005042 tartrate dehydrogenase; Region: TTC; TIGR02089 446468005043 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 446468005044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468005045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468005046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468005047 dimerization interface [polypeptide binding]; other site 446468005048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468005049 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468005050 Probable transposase; Region: OrfB_IS605; pfam01385 446468005051 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446468005052 catalytic residues [active] 446468005053 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468005054 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468005055 DNA binding site [nucleotide binding] 446468005056 domain linker motif; other site 446468005057 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468005058 dimerization interface [polypeptide binding]; other site 446468005059 ligand binding site [chemical binding]; other site 446468005060 AAA ATPase domain; Region: AAA_16; pfam13191 446468005061 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 446468005062 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 446468005063 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446468005064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468005065 binding surface 446468005066 TPR motif; other site 446468005067 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468005068 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 446468005069 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 446468005070 active site 446468005071 homodimer interface [polypeptide binding]; other site 446468005072 Response regulator receiver domain; Region: Response_reg; pfam00072 446468005073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005074 active site 446468005075 phosphorylation site [posttranslational modification] 446468005076 intermolecular recognition site; other site 446468005077 dimerization interface [polypeptide binding]; other site 446468005078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005079 DNA binding residues [nucleotide binding] 446468005080 Histidine kinase; Region: HisKA_3; pfam07730 446468005081 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468005082 ATP binding site [chemical binding]; other site 446468005083 Mg2+ binding site [ion binding]; other site 446468005084 G-X-G motif; other site 446468005085 CAAX protease self-immunity; Region: Abi; pfam02517 446468005086 Protein of unknown function (DUF419); Region: DUF419; cl15265 446468005087 hypothetical protein; Provisional; Region: PRK07758 446468005088 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 446468005089 active site 446468005090 SUMO-1 interface [polypeptide binding]; other site 446468005091 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 446468005092 Winged helix-turn helix; Region: HTH_29; pfam13551 446468005093 Integrase core domain; Region: rve; pfam00665 446468005094 Integrase core domain; Region: rve_3; pfam13683 446468005095 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446468005096 putative metal binding residues [ion binding]; other site 446468005097 signature motif; other site 446468005098 dimer interface [polypeptide binding]; other site 446468005099 active site 446468005100 polyP binding site; other site 446468005101 substrate binding site [chemical binding]; other site 446468005102 acceptor-phosphate pocket; other site 446468005103 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 446468005104 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 446468005105 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 446468005106 Predicted acetyltransferase [General function prediction only]; Region: COG3153 446468005107 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468005108 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468005109 Probable transposase; Region: OrfB_IS605; pfam01385 446468005110 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468005111 GTPase RsgA; Reviewed; Region: PRK01889 446468005112 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446468005113 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446468005114 GTP/Mg2+ binding site [chemical binding]; other site 446468005115 G4 box; other site 446468005116 G5 box; other site 446468005117 G1 box; other site 446468005118 Switch I region; other site 446468005119 G2 box; other site 446468005120 G3 box; other site 446468005121 Switch II region; other site 446468005122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468005123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468005124 dimerization interface [polypeptide binding]; other site 446468005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468005126 dimer interface [polypeptide binding]; other site 446468005127 phosphorylation site [posttranslational modification] 446468005128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468005129 ATP binding site [chemical binding]; other site 446468005130 Mg2+ binding site [ion binding]; other site 446468005131 G-X-G motif; other site 446468005132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468005133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005134 active site 446468005135 phosphorylation site [posttranslational modification] 446468005136 intermolecular recognition site; other site 446468005137 dimerization interface [polypeptide binding]; other site 446468005138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468005139 DNA binding site [nucleotide binding] 446468005140 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 446468005141 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493 446468005142 Na binding site [ion binding]; other site 446468005143 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446468005144 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 446468005145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446468005146 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446468005147 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468005148 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446468005149 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468005150 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 446468005151 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 446468005152 active site 446468005153 citrylCoA binding site [chemical binding]; other site 446468005154 oxalacetate binding site [chemical binding]; other site 446468005155 coenzyme A binding site [chemical binding]; other site 446468005156 catalytic triad [active] 446468005157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468005158 Ligand Binding Site [chemical binding]; other site 446468005159 Universal stress protein family; Region: Usp; pfam00582 446468005160 Ligand Binding Site [chemical binding]; other site 446468005161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005162 putative substrate translocation pore; other site 446468005163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005164 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468005165 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468005166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005167 Walker A/P-loop; other site 446468005168 ATP binding site [chemical binding]; other site 446468005169 Q-loop/lid; other site 446468005170 ABC transporter signature motif; other site 446468005171 Walker B; other site 446468005172 D-loop; other site 446468005173 H-loop/switch region; other site 446468005174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005175 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468005176 Walker A/P-loop; other site 446468005177 ATP binding site [chemical binding]; other site 446468005178 Q-loop/lid; other site 446468005179 ABC transporter signature motif; other site 446468005180 Walker B; other site 446468005181 D-loop; other site 446468005182 H-loop/switch region; other site 446468005183 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446468005184 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446468005185 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468005186 dimerization interface [polypeptide binding]; other site 446468005187 putative DNA binding site [nucleotide binding]; other site 446468005188 putative Zn2+ binding site [ion binding]; other site 446468005189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468005190 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446468005191 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446468005192 TIGR03086 family protein; Region: TIGR03086 446468005193 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446468005194 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446468005195 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 446468005196 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 446468005197 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 446468005198 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446468005199 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446468005200 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 446468005201 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 446468005202 dimanganese center [ion binding]; other site 446468005203 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 446468005204 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 446468005205 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 446468005206 active site 446468005207 metal binding site [ion binding]; metal-binding site 446468005208 homotetramer interface [polypeptide binding]; other site 446468005209 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446468005210 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446468005211 putative acyl-acceptor binding pocket; other site 446468005212 threonine dehydratase; Provisional; Region: PRK08246 446468005213 hypothetical protein; Provisional; Region: PRK06815 446468005214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468005215 catalytic residue [active] 446468005216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468005217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468005218 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446468005219 putative dimerization interface [polypeptide binding]; other site 446468005220 Predicted membrane protein [Function unknown]; Region: COG2860 446468005221 UPF0126 domain; Region: UPF0126; pfam03458 446468005222 UPF0126 domain; Region: UPF0126; pfam03458 446468005223 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 446468005224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468005225 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468005226 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446468005227 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 446468005228 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 446468005229 FAD binding pocket [chemical binding]; other site 446468005230 FAD binding motif [chemical binding]; other site 446468005231 phosphate binding motif [ion binding]; other site 446468005232 NAD binding pocket [chemical binding]; other site 446468005233 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 446468005234 hypothetical protein; Provisional; Region: PRK01346 446468005235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468005236 Coenzyme A binding pocket [chemical binding]; other site 446468005237 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468005238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005239 Walker A/P-loop; other site 446468005240 ATP binding site [chemical binding]; other site 446468005241 Q-loop/lid; other site 446468005242 ABC transporter signature motif; other site 446468005243 Walker B; other site 446468005244 D-loop; other site 446468005245 H-loop/switch region; other site 446468005246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468005247 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 446468005248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446468005249 ligand binding site [chemical binding]; other site 446468005250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468005251 hypothetical protein; Provisional; Region: PRK01346 446468005252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468005253 Coenzyme A binding pocket [chemical binding]; other site 446468005254 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446468005255 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468005256 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468005257 catalytic residue [active] 446468005258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468005259 MarR family; Region: MarR; pfam01047 446468005260 MarR family; Region: MarR_2; cl17246 446468005261 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468005262 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 446468005263 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468005264 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 446468005265 fumarylacetoacetase; Region: PLN02856 446468005266 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 446468005267 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 446468005268 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468005269 DNA binding residues [nucleotide binding] 446468005270 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468005271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468005272 Mg2+ binding site [ion binding]; other site 446468005273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468005274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468005275 non-specific DNA binding site [nucleotide binding]; other site 446468005276 salt bridge; other site 446468005277 sequence-specific DNA binding site [nucleotide binding]; other site 446468005278 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468005279 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468005280 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005281 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005282 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005283 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005284 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005285 Beta propeller repeats in Physarum polycephalum tectonins, Limulus lectin L-6 and animal hypothetical proteins; Region: TECPR; smart00706 446468005286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005287 S-adenosylmethionine binding site [chemical binding]; other site 446468005288 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468005289 DNA-binding site [nucleotide binding]; DNA binding site 446468005290 RNA-binding motif; other site 446468005291 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446468005292 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 446468005293 F0F1-type ATP synthase, beta subunit [Energy production and conversion]; Region: AtpD; COG0055 446468005294 Protein of unknown function (DUF998); Region: DUF998; pfam06197 446468005295 YCII-related domain; Region: YCII; cl00999 446468005296 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446468005297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468005298 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468005299 DNA binding residues [nucleotide binding] 446468005300 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 446468005301 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446468005302 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446468005303 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446468005304 AAA domain; Region: AAA_21; pfam13304 446468005305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005306 S-adenosylmethionine binding site [chemical binding]; other site 446468005307 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468005308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468005309 sequence-specific DNA binding site [nucleotide binding]; other site 446468005310 salt bridge; other site 446468005311 Cupin domain; Region: Cupin_2; pfam07883 446468005312 AAA ATPase domain; Region: AAA_16; pfam13191 446468005313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005315 DNA binding residues [nucleotide binding] 446468005316 dimerization interface [polypeptide binding]; other site 446468005317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468005318 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 446468005319 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446468005320 substrate binding pocket [chemical binding]; other site 446468005321 catalytic triad [active] 446468005322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468005323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468005324 salt bridge; other site 446468005325 non-specific DNA binding site [nucleotide binding]; other site 446468005326 sequence-specific DNA binding site [nucleotide binding]; other site 446468005327 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468005328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468005329 NAD(P) binding site [chemical binding]; other site 446468005330 active site 446468005331 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468005332 PAS domain; Region: PAS_9; pfam13426 446468005333 putative active site [active] 446468005334 heme pocket [chemical binding]; other site 446468005335 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468005336 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446468005337 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468005338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005340 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 446468005341 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468005342 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 446468005343 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 446468005344 inhibitor site; inhibition site 446468005345 active site 446468005346 dimer interface [polypeptide binding]; other site 446468005347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468005348 NAD(P) binding site [chemical binding]; other site 446468005349 active site 446468005350 BCCT family transporter; Region: BCCT; pfam02028 446468005351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005353 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 446468005354 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446468005355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005356 Walker A/P-loop; other site 446468005357 ATP binding site [chemical binding]; other site 446468005358 Q-loop/lid; other site 446468005359 ABC transporter signature motif; other site 446468005360 Walker B; other site 446468005361 D-loop; other site 446468005362 H-loop/switch region; other site 446468005363 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446468005364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468005365 dimer interface [polypeptide binding]; other site 446468005366 conserved gate region; other site 446468005367 putative PBP binding loops; other site 446468005368 ABC-ATPase subunit interface; other site 446468005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446468005370 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 446468005371 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446468005372 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 446468005373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468005374 ligand binding site [chemical binding]; other site 446468005375 dimerization interface [polypeptide binding]; other site 446468005376 YCII-related domain; Region: YCII; cl00999 446468005377 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446468005378 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468005379 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446468005380 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468005381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468005382 NAD(P) binding site [chemical binding]; other site 446468005383 active site 446468005384 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446468005385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005386 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446468005387 classical (c) SDRs; Region: SDR_c; cd05233 446468005388 NAD(P) binding site [chemical binding]; other site 446468005389 active site 446468005390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468005391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468005392 DNA binding site [nucleotide binding] 446468005393 domain linker motif; other site 446468005394 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468005395 ligand binding site [chemical binding]; other site 446468005396 dimerization interface [polypeptide binding]; other site 446468005397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468005398 putative PBP binding loops; other site 446468005399 ABC-ATPase subunit interface; other site 446468005400 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446468005401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468005402 dimer interface [polypeptide binding]; other site 446468005403 conserved gate region; other site 446468005404 putative PBP binding loops; other site 446468005405 ABC-ATPase subunit interface; other site 446468005406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468005407 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468005408 Probable transposase; Region: OrfB_IS605; pfam01385 446468005409 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468005410 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446468005411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005412 Walker A/P-loop; other site 446468005413 ATP binding site [chemical binding]; other site 446468005414 Q-loop/lid; other site 446468005415 ABC transporter signature motif; other site 446468005416 Walker B; other site 446468005417 D-loop; other site 446468005418 H-loop/switch region; other site 446468005419 TOBE domain; Region: TOBE_2; pfam08402 446468005420 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 446468005421 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446468005422 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 446468005423 active site 446468005424 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 446468005425 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468005426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468005427 active site 446468005428 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 446468005429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005431 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 446468005432 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 446468005433 NAD(P) binding site [chemical binding]; other site 446468005434 catalytic residues [active] 446468005435 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446468005436 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 446468005437 D-pathway; other site 446468005438 Putative ubiquinol binding site [chemical binding]; other site 446468005439 Low-spin heme (heme b) binding site [chemical binding]; other site 446468005440 Putative water exit pathway; other site 446468005441 Binuclear center (heme o3/CuB) [ion binding]; other site 446468005442 K-pathway; other site 446468005443 Putative proton exit pathway; other site 446468005444 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 446468005445 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 446468005446 NodB motif; other site 446468005447 active site 446468005448 catalytic site [active] 446468005449 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 446468005450 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 446468005451 putative substrate binding pocket [chemical binding]; other site 446468005452 AC domain interface; other site 446468005453 catalytic triad [active] 446468005454 AB domain interface; other site 446468005455 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 446468005456 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468005457 tetrameric interface [polypeptide binding]; other site 446468005458 NAD binding site [chemical binding]; other site 446468005459 catalytic residues [active] 446468005460 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468005461 MarR family; Region: MarR; pfam01047 446468005462 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 446468005463 carbon starvation protein A; Provisional; Region: PRK15015 446468005464 Carbon starvation protein CstA; Region: CstA; pfam02554 446468005465 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 446468005466 Protein of unknown function (DUF466); Region: DUF466; pfam04328 446468005467 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446468005468 Domain of unknown function DUF21; Region: DUF21; pfam01595 446468005469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446468005470 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 446468005471 Domain of unknown function DUF21; Region: DUF21; pfam01595 446468005472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 446468005473 Transporter associated domain; Region: CorC_HlyC; smart01091 446468005474 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446468005475 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 446468005476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005477 S-adenosylmethionine binding site [chemical binding]; other site 446468005478 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 446468005479 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 446468005480 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 446468005481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005483 short chain dehydrogenase; Provisional; Region: PRK06197 446468005484 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446468005485 putative NAD(P) binding site [chemical binding]; other site 446468005486 active site 446468005487 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 446468005488 DNA binding residues [nucleotide binding] 446468005489 putative dimer interface [polypeptide binding]; other site 446468005490 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 446468005491 DNA binding residues [nucleotide binding] 446468005492 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468005493 putative dimer interface [polypeptide binding]; other site 446468005494 Erythromycin esterase; Region: Erythro_esteras; pfam05139 446468005495 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468005496 nudix motif; other site 446468005497 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 446468005498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468005499 motif II; other site 446468005500 hypothetical protein; Provisional; Region: PRK13685 446468005501 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446468005502 metal ion-dependent adhesion site (MIDAS); other site 446468005503 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446468005504 Protein of unknown function DUF58; Region: DUF58; pfam01882 446468005505 MoxR-like ATPases [General function prediction only]; Region: COG0714 446468005506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468005507 Walker A motif; other site 446468005508 ATP binding site [chemical binding]; other site 446468005509 Walker B motif; other site 446468005510 arginine finger; other site 446468005511 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 446468005512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005513 putative substrate translocation pore; other site 446468005514 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468005515 acyl-activating enzyme (AAE) consensus motif; other site 446468005516 active site 446468005517 AMP binding site [chemical binding]; other site 446468005518 CoA binding site [chemical binding]; other site 446468005519 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468005520 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468005521 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005523 active site 446468005524 phosphorylation site [posttranslational modification] 446468005525 intermolecular recognition site; other site 446468005526 dimerization interface [polypeptide binding]; other site 446468005527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005528 DNA binding residues [nucleotide binding] 446468005529 dimerization interface [polypeptide binding]; other site 446468005530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468005531 Histidine kinase; Region: HisKA_3; pfam07730 446468005532 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468005533 ATP binding site [chemical binding]; other site 446468005534 G-X-G motif; other site 446468005535 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 446468005536 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 446468005537 active site 446468005538 catalytic residues [active] 446468005539 metal binding site [ion binding]; metal-binding site 446468005540 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 446468005541 RNA/DNA hybrid binding site [nucleotide binding]; other site 446468005542 active site 446468005543 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 446468005544 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 446468005545 DNA binding residues [nucleotide binding] 446468005546 dimer interface [polypeptide binding]; other site 446468005547 [2Fe-2S] cluster binding site [ion binding]; other site 446468005548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005549 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 446468005550 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446468005551 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 446468005552 active site 446468005553 purine riboside binding site [chemical binding]; other site 446468005554 Short C-terminal domain; Region: SHOCT; pfam09851 446468005555 Histidine kinase; Region: HisKA_3; pfam07730 446468005556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005558 active site 446468005559 phosphorylation site [posttranslational modification] 446468005560 intermolecular recognition site; other site 446468005561 dimerization interface [polypeptide binding]; other site 446468005562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005563 dimerization interface [polypeptide binding]; other site 446468005564 DNA binding residues [nucleotide binding] 446468005565 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446468005566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468005567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468005568 catalytic residue [active] 446468005569 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468005570 DNA binding residues [nucleotide binding] 446468005571 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468005572 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 446468005573 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446468005574 hypothetical protein; Provisional; Region: PRK07236 446468005575 FAD binding domain; Region: FAD_binding_3; pfam01494 446468005576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005578 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468005579 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446468005580 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446468005581 putative dimer interface [polypeptide binding]; other site 446468005582 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 446468005583 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446468005584 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005585 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005586 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446468005587 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468005588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468005589 catalytic residue [active] 446468005590 Phosphotransferase enzyme family; Region: APH; pfam01636 446468005591 serine/threonine protein kinase; Provisional; Region: PRK14879 446468005592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468005593 MarR family; Region: MarR_2; cl17246 446468005594 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468005595 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446468005596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468005597 putative DNA binding site [nucleotide binding]; other site 446468005598 putative Zn2+ binding site [ion binding]; other site 446468005599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468005600 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 446468005601 ribonuclease Z; Reviewed; Region: PRK00055 446468005602 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446468005603 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446468005604 active site 446468005605 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 446468005606 active site 1 [active] 446468005607 dimer interface [polypeptide binding]; other site 446468005608 hexamer interface [polypeptide binding]; other site 446468005609 active site 2 [active] 446468005610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468005611 short chain dehydrogenase; Provisional; Region: PRK12937 446468005612 NAD(P) binding site [chemical binding]; other site 446468005613 active site 446468005614 Helix-turn-helix domain; Region: HTH_31; pfam13560 446468005615 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468005616 active site 446468005617 substrate binding site [chemical binding]; other site 446468005618 ATP binding site [chemical binding]; other site 446468005619 Phosphotransferase enzyme family; Region: APH; pfam01636 446468005620 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446468005621 dimer interface [polypeptide binding]; other site 446468005622 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468005623 HTH domain; Region: HTH_11; pfam08279 446468005624 WYL domain; Region: WYL; pfam13280 446468005625 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446468005626 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446468005627 oligomer interface [polypeptide binding]; other site 446468005628 metal binding site [ion binding]; metal-binding site 446468005629 metal binding site [ion binding]; metal-binding site 446468005630 putative Cl binding site [ion binding]; other site 446468005631 basic sphincter; other site 446468005632 hydrophobic gate; other site 446468005633 periplasmic entrance; other site 446468005634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005635 WHG domain; Region: WHG; pfam13305 446468005636 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 446468005637 active site 446468005638 catalytic triad [active] 446468005639 oxyanion hole [active] 446468005640 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 446468005641 Uncharacterized conserved protein [Function unknown]; Region: COG1656 446468005642 Protein of unknown function DUF82; Region: DUF82; pfam01927 446468005643 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 446468005644 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468005645 MOSC domain; Region: MOSC; pfam03473 446468005646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468005647 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468005648 NAD(P) binding site [chemical binding]; other site 446468005649 active site 446468005650 FAD binding domain; Region: FAD_binding_4; pfam01565 446468005651 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 446468005652 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 446468005653 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468005654 DNA-binding site [nucleotide binding]; DNA binding site 446468005655 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468005656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468005657 homodimer interface [polypeptide binding]; other site 446468005658 catalytic residue [active] 446468005659 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 446468005660 catalytic core [active] 446468005661 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 446468005662 intracellular protease, PfpI family; Region: PfpI; TIGR01382 446468005663 proposed catalytic triad [active] 446468005664 conserved cys residue [active] 446468005665 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 446468005666 Na2 binding site [ion binding]; other site 446468005667 putative substrate binding site 1 [chemical binding]; other site 446468005668 Na binding site 1 [ion binding]; other site 446468005669 putative substrate binding site 2 [chemical binding]; other site 446468005670 Pirin-related protein [General function prediction only]; Region: COG1741 446468005671 Pirin; Region: Pirin; pfam02678 446468005672 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 446468005673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468005674 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468005675 Protein of unknown function (DUF993); Region: DUF993; pfam06187 446468005676 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 446468005677 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446468005678 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 446468005679 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446468005680 catalytic residue [active] 446468005681 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 446468005682 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446468005683 active site pocket [active] 446468005684 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 446468005685 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446468005686 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005688 active site 446468005689 phosphorylation site [posttranslational modification] 446468005690 intermolecular recognition site; other site 446468005691 dimerization interface [polypeptide binding]; other site 446468005692 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005693 DNA binding residues [nucleotide binding] 446468005694 dimerization interface [polypeptide binding]; other site 446468005695 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468005696 Histidine kinase; Region: HisKA_3; pfam07730 446468005697 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468005698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005699 S-adenosylmethionine binding site [chemical binding]; other site 446468005700 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 446468005701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468005702 non-specific DNA binding site [nucleotide binding]; other site 446468005703 salt bridge; other site 446468005704 sequence-specific DNA binding site [nucleotide binding]; other site 446468005705 Cupin domain; Region: Cupin_2; pfam07883 446468005706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468005707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468005708 DNA binding site [nucleotide binding] 446468005709 domain linker motif; other site 446468005710 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468005711 dimerization interface [polypeptide binding]; other site 446468005712 ligand binding site [chemical binding]; other site 446468005713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468005714 extended (e) SDRs; Region: SDR_e; cd08946 446468005715 NAD(P) binding site [chemical binding]; other site 446468005716 active site 446468005717 substrate binding site [chemical binding]; other site 446468005718 Methane oxygenase PmoA; Region: PmoA; pfam14100 446468005719 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468005720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468005721 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468005722 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468005723 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446468005724 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446468005725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468005726 dimer interface [polypeptide binding]; other site 446468005727 putative PBP binding loops; other site 446468005728 ABC-ATPase subunit interface; other site 446468005729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468005730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468005731 dimer interface [polypeptide binding]; other site 446468005732 conserved gate region; other site 446468005733 putative PBP binding loops; other site 446468005734 ABC-ATPase subunit interface; other site 446468005735 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468005736 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468005737 EamA-like transporter family; Region: EamA; pfam00892 446468005738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 446468005739 Cupin domain; Region: Cupin_2; pfam07883 446468005740 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468005741 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468005742 Isochorismatase family; Region: Isochorismatase; pfam00857 446468005743 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446468005744 catalytic triad [active] 446468005745 conserved cis-peptide bond; other site 446468005746 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 446468005747 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446468005748 conserved cys residue [active] 446468005749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468005750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468005751 glutamate dehydrogenase; Provisional; Region: PRK09414 446468005752 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 446468005753 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 446468005754 NAD(P) binding pocket [chemical binding]; other site 446468005755 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468005756 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468005757 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468005758 active site 446468005759 catalytic tetrad [active] 446468005760 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468005761 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468005762 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468005763 DNA binding residues [nucleotide binding] 446468005764 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468005765 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468005766 active site 446468005767 metal binding site [ion binding]; metal-binding site 446468005768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468005769 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 446468005770 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446468005771 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446468005772 conserved cys residue [active] 446468005773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468005774 Cupin domain; Region: Cupin_2; cl17218 446468005775 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 446468005776 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468005777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468005778 Coenzyme A binding pocket [chemical binding]; other site 446468005779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005780 S-adenosylmethionine binding site [chemical binding]; other site 446468005781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005783 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468005784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005785 Walker A/P-loop; other site 446468005786 ATP binding site [chemical binding]; other site 446468005787 Q-loop/lid; other site 446468005788 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446468005789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005790 Walker A/P-loop; other site 446468005791 ATP binding site [chemical binding]; other site 446468005792 Q-loop/lid; other site 446468005793 ABC transporter; Region: ABC_tran; pfam00005 446468005794 ABC transporter signature motif; other site 446468005795 Walker B; other site 446468005796 D-loop; other site 446468005797 H-loop/switch region; other site 446468005798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005799 Walker A/P-loop; other site 446468005800 ATP binding site [chemical binding]; other site 446468005801 Q-loop/lid; other site 446468005802 ABC transporter signature motif; other site 446468005803 Walker B; other site 446468005804 D-loop; other site 446468005805 H-loop/switch region; other site 446468005806 Predicted transcriptional regulator [Transcription]; Region: COG2378 446468005807 WYL domain; Region: WYL; pfam13280 446468005808 DinB superfamily; Region: DinB_2; pfam12867 446468005809 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005810 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005811 maltose O-acetyltransferase; Provisional; Region: PRK10092 446468005812 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 446468005813 active site 446468005814 substrate binding site [chemical binding]; other site 446468005815 trimer interface [polypeptide binding]; other site 446468005816 CoA binding site [chemical binding]; other site 446468005817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468005818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005819 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468005820 Walker A/P-loop; other site 446468005821 ATP binding site [chemical binding]; other site 446468005822 Q-loop/lid; other site 446468005823 ABC transporter signature motif; other site 446468005824 Walker B; other site 446468005825 D-loop; other site 446468005826 H-loop/switch region; other site 446468005827 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 446468005828 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446468005829 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468005830 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468005831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468005832 dimerization interface [polypeptide binding]; other site 446468005833 Putative sensor; Region: Sensor; pfam13796 446468005834 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 446468005835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005837 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468005838 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468005839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005840 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005841 DNA binding residues [nucleotide binding] 446468005842 Predicted ATPase [General function prediction only]; Region: COG3903 446468005843 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 446468005844 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468005845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468005846 Coenzyme A binding pocket [chemical binding]; other site 446468005847 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468005848 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 446468005849 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446468005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005851 S-adenosylmethionine binding site [chemical binding]; other site 446468005852 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 446468005853 dimer interface [polypeptide binding]; other site 446468005854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005855 S-adenosylmethionine binding site [chemical binding]; other site 446468005856 Histidine kinase; Region: HisKA_3; pfam07730 446468005857 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468005858 Mg2+ binding site [ion binding]; other site 446468005859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005861 active site 446468005862 phosphorylation site [posttranslational modification] 446468005863 intermolecular recognition site; other site 446468005864 dimerization interface [polypeptide binding]; other site 446468005865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005866 DNA binding residues [nucleotide binding] 446468005867 dimerization interface [polypeptide binding]; other site 446468005868 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468005869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005870 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 446468005871 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 446468005872 Histidine kinase; Region: HisKA_3; pfam07730 446468005873 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468005874 ATP binding site [chemical binding]; other site 446468005875 Mg2+ binding site [ion binding]; other site 446468005876 G-X-G motif; other site 446468005877 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468005879 active site 446468005880 phosphorylation site [posttranslational modification] 446468005881 intermolecular recognition site; other site 446468005882 dimerization interface [polypeptide binding]; other site 446468005883 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005884 DNA binding residues [nucleotide binding] 446468005885 dimerization interface [polypeptide binding]; other site 446468005886 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446468005887 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446468005888 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446468005889 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468005890 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468005891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468005892 Coenzyme A binding pocket [chemical binding]; other site 446468005893 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468005894 putative active site [active] 446468005895 HTH domain; Region: HTH_11; pfam08279 446468005896 Predicted transcriptional regulator [Transcription]; Region: COG2378 446468005897 WYL domain; Region: WYL; pfam13280 446468005898 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468005899 homotrimer interaction site [polypeptide binding]; other site 446468005900 putative active site [active] 446468005901 Amidinotransferase; Region: Amidinotransf; cl12043 446468005902 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446468005903 yiaA/B two helix domain; Region: YiaAB; cl01759 446468005904 biotin synthase; Validated; Region: PRK06256 446468005905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468005906 FeS/SAM binding site; other site 446468005907 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 446468005908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468005909 active site 446468005910 substrate binding site [chemical binding]; other site 446468005911 ATP binding site [chemical binding]; other site 446468005912 Phosphotransferase enzyme family; Region: APH; pfam01636 446468005913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005915 WHG domain; Region: WHG; pfam13305 446468005916 short chain dehydrogenase; Provisional; Region: PRK06197 446468005917 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446468005918 putative NAD(P) binding site [chemical binding]; other site 446468005919 active site 446468005920 SnoaL-like domain; Region: SnoaL_4; pfam13577 446468005921 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 446468005922 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468005923 motif II; other site 446468005924 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 446468005925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005926 putative substrate translocation pore; other site 446468005927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468005928 Short C-terminal domain; Region: SHOCT; pfam09851 446468005929 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446468005930 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446468005931 glutamine binding [chemical binding]; other site 446468005932 catalytic triad [active] 446468005933 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 446468005934 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 446468005935 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446468005936 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 446468005937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 446468005938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005939 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446468005940 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 446468005941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468005942 S-adenosylmethionine binding site [chemical binding]; other site 446468005943 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 446468005944 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446468005945 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446468005946 FeoA domain; Region: FeoA; pfam04023 446468005947 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468005948 putative active site [active] 446468005949 PhoD-like phosphatase; Region: PhoD; pfam09423 446468005950 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446468005951 putative active site [active] 446468005952 putative metal binding site [ion binding]; other site 446468005953 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468005954 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 446468005955 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468005956 NAD binding site [chemical binding]; other site 446468005957 substrate binding site [chemical binding]; other site 446468005958 putative active site [active] 446468005959 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468005960 MarR family; Region: MarR_2; pfam12802 446468005961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468005962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468005963 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468005964 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468005965 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468005966 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 446468005967 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 446468005968 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 446468005969 active site 446468005970 catalytic site [active] 446468005971 substrate binding site [chemical binding]; other site 446468005972 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 446468005973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468005974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468005975 Walker A/P-loop; other site 446468005976 ATP binding site [chemical binding]; other site 446468005977 Q-loop/lid; other site 446468005978 ABC transporter signature motif; other site 446468005979 Walker B; other site 446468005980 D-loop; other site 446468005981 H-loop/switch region; other site 446468005982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468005983 Histidine kinase; Region: HisKA_3; pfam07730 446468005984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468005985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468005986 DNA binding residues [nucleotide binding] 446468005987 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468005988 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468005989 active site 446468005990 ATP binding site [chemical binding]; other site 446468005991 substrate binding site [chemical binding]; other site 446468005992 activation loop (A-loop); other site 446468005993 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446468005994 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468005995 YCII-related domain; Region: YCII; cl00999 446468005996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468005997 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446468005998 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468005999 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 446468006000 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 446468006001 metal binding site [ion binding]; metal-binding site 446468006002 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446468006003 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 446468006004 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 446468006005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006006 ABC-ATPase subunit interface; other site 446468006007 dimer interface [polypeptide binding]; other site 446468006008 putative PBP binding regions; other site 446468006009 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468006010 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446468006011 putative NAD(P) binding site [chemical binding]; other site 446468006012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468006013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468006014 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446468006015 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 446468006016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446468006017 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 446468006018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468006019 active site 446468006020 metal binding site [ion binding]; metal-binding site 446468006021 hexamer interface [polypeptide binding]; other site 446468006022 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 446468006023 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446468006024 active site 2 [active] 446468006025 active site 1 [active] 446468006026 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 446468006027 active site 1 [active] 446468006028 active site 2 [active] 446468006029 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446468006030 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468006031 DNA binding residues [nucleotide binding] 446468006032 dimer interface [polypeptide binding]; other site 446468006033 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446468006034 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446468006035 dimer interface [polypeptide binding]; other site 446468006036 ADP-ribose binding site [chemical binding]; other site 446468006037 active site 446468006038 nudix motif; other site 446468006039 metal binding site [ion binding]; metal-binding site 446468006040 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468006041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468006042 Walker A/P-loop; other site 446468006043 ATP binding site [chemical binding]; other site 446468006044 Q-loop/lid; other site 446468006045 ABC transporter signature motif; other site 446468006046 Walker B; other site 446468006047 D-loop; other site 446468006048 H-loop/switch region; other site 446468006049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468006050 Walker A/P-loop; other site 446468006051 ATP binding site [chemical binding]; other site 446468006052 Q-loop/lid; other site 446468006053 ABC transporter signature motif; other site 446468006054 Walker B; other site 446468006055 D-loop; other site 446468006056 Predicted transcriptional regulator [Transcription]; Region: COG2378 446468006057 HTH domain; Region: HTH_11; pfam08279 446468006058 WYL domain; Region: WYL; pfam13280 446468006059 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468006060 homotrimer interaction site [polypeptide binding]; other site 446468006061 putative active site [active] 446468006062 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 446468006063 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468006064 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 446468006065 AsnC family; Region: AsnC_trans_reg; pfam01037 446468006066 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468006067 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468006068 DNA binding residues [nucleotide binding] 446468006069 dimer interface [polypeptide binding]; other site 446468006070 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468006071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468006072 S-adenosylmethionine binding site [chemical binding]; other site 446468006073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468006074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468006075 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006076 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468006077 NAD(P) binding site [chemical binding]; other site 446468006078 active site 446468006079 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 446468006080 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 446468006081 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446468006082 [4Fe-4S] binding site [ion binding]; other site 446468006083 molybdopterin cofactor binding site; other site 446468006084 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 446468006085 molybdopterin cofactor binding site; other site 446468006086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 446468006087 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446468006088 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446468006089 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 446468006090 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468006091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006092 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446468006093 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 446468006094 catalytic residues [active] 446468006095 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 446468006096 nitrite reductase subunit NirD; Provisional; Region: PRK14989 446468006097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468006098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468006099 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 446468006100 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446468006101 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 446468006102 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 446468006103 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446468006104 active site 446468006105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468006106 DNA binding site [nucleotide binding] 446468006107 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446468006108 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446468006109 putative active site [active] 446468006110 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 446468006111 putative active site [active] 446468006112 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446468006113 active site 446468006114 catalytic residues [active] 446468006115 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 446468006116 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 446468006117 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 446468006118 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 446468006119 Part of AAA domain; Region: AAA_19; pfam13245 446468006120 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446468006121 AAA domain; Region: AAA_12; pfam13087 446468006122 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468006123 active site 446468006124 DNA binding site [nucleotide binding] 446468006125 Int/Topo IB signature motif; other site 446468006126 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 446468006127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468006128 Histidine kinase; Region: HisKA_3; pfam07730 446468006129 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468006130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468006131 active site 446468006132 phosphorylation site [posttranslational modification] 446468006133 intermolecular recognition site; other site 446468006134 dimerization interface [polypeptide binding]; other site 446468006135 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468006136 DNA binding residues [nucleotide binding] 446468006137 dimerization interface [polypeptide binding]; other site 446468006138 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446468006139 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446468006140 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468006141 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 446468006142 putative active site [active] 446468006143 putative catalytic site [active] 446468006144 putative DNA binding site [nucleotide binding]; other site 446468006145 putative phosphate binding site [ion binding]; other site 446468006146 metal binding site A [ion binding]; metal-binding site 446468006147 putative AP binding site [nucleotide binding]; other site 446468006148 putative metal binding site B [ion binding]; other site 446468006149 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468006150 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 446468006151 active site 446468006152 DNA binding site [nucleotide binding] 446468006153 Int/Topo IB signature motif; other site 446468006154 Acetokinase family; Region: Acetate_kinase; cl17229 446468006155 putative phosphoketolase; Provisional; Region: PRK05261 446468006156 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 446468006157 TPP-binding site; other site 446468006158 XFP C-terminal domain; Region: XFP_C; pfam09363 446468006159 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 446468006160 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468006161 acyl-activating enzyme (AAE) consensus motif; other site 446468006162 AMP binding site [chemical binding]; other site 446468006163 active site 446468006164 CoA binding site [chemical binding]; other site 446468006165 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 446468006166 aromatic arch; other site 446468006167 DCoH dimer interaction site [polypeptide binding]; other site 446468006168 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 446468006169 DCoH tetramer interaction site [polypeptide binding]; other site 446468006170 substrate binding site [chemical binding]; other site 446468006171 Nitrate and nitrite sensing; Region: NIT; pfam08376 446468006172 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468006173 ATP binding site [chemical binding]; other site 446468006174 Mg2+ binding site [ion binding]; other site 446468006175 G-X-G motif; other site 446468006176 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 446468006177 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468006178 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446468006179 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468006180 G1 box; other site 446468006181 GTP/Mg2+ binding site [chemical binding]; other site 446468006182 G2 box; other site 446468006183 Switch I region; other site 446468006184 G3 box; other site 446468006185 Switch II region; other site 446468006186 G4 box; other site 446468006187 G5 box; other site 446468006188 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468006189 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468006190 Walker A/P-loop; other site 446468006191 ATP binding site [chemical binding]; other site 446468006192 Q-loop/lid; other site 446468006193 ABC transporter signature motif; other site 446468006194 Walker B; other site 446468006195 D-loop; other site 446468006196 H-loop/switch region; other site 446468006197 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 446468006198 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006199 ABC-ATPase subunit interface; other site 446468006200 dimer interface [polypeptide binding]; other site 446468006201 putative PBP binding regions; other site 446468006202 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468006203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006204 ABC-ATPase subunit interface; other site 446468006205 dimer interface [polypeptide binding]; other site 446468006206 putative PBP binding regions; other site 446468006207 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 446468006208 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446468006209 siderophore binding site; other site 446468006210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468006211 hypothetical protein; Provisional; Region: PRK10621 446468006212 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446468006213 Predicted esterase [General function prediction only]; Region: COG0400 446468006214 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 446468006215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468006216 Zn binding site [ion binding]; other site 446468006217 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 446468006218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468006219 Zn binding site [ion binding]; other site 446468006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006221 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468006222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468006223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468006224 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 446468006225 putative dimerization interface [polypeptide binding]; other site 446468006226 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 446468006227 classical (c) SDRs; Region: SDR_c; cd05233 446468006228 NAD(P) binding site [chemical binding]; other site 446468006229 active site 446468006230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468006231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468006232 active site 446468006233 ATP binding site [chemical binding]; other site 446468006234 substrate binding site [chemical binding]; other site 446468006235 activation loop (A-loop); other site 446468006236 Cytochrome P450; Region: p450; cl12078 446468006237 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468006238 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446468006239 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 446468006240 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 446468006241 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446468006242 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446468006243 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446468006244 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446468006245 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468006246 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 446468006247 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 446468006248 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446468006249 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 446468006250 catalytic loop [active] 446468006251 iron binding site [ion binding]; other site 446468006252 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446468006253 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 446468006254 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 446468006255 active site 446468006256 putative substrate binding pocket [chemical binding]; other site 446468006257 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 446468006258 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 446468006259 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446468006260 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446468006261 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 446468006262 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446468006263 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 446468006264 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 446468006265 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 446468006266 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446468006267 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446468006268 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 446468006269 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 446468006270 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 446468006271 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 446468006272 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468006273 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468006274 acyl-activating enzyme (AAE) consensus motif; other site 446468006275 AMP binding site [chemical binding]; other site 446468006276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468006277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006278 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446468006279 NAD(P) binding site [chemical binding]; other site 446468006280 active site 446468006281 active site 446468006282 iron coordination sites [ion binding]; other site 446468006283 substrate binding pocket [chemical binding]; other site 446468006284 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 446468006285 classical (c) SDRs; Region: SDR_c; cd05233 446468006286 NAD(P) binding site [chemical binding]; other site 446468006287 active site 446468006288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468006289 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 446468006290 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446468006291 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468006292 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 446468006293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468006294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468006295 homodimer interface [polypeptide binding]; other site 446468006296 catalytic residue [active] 446468006297 GAF domain; Region: GAF; pfam01590 446468006298 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446468006299 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468006300 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 446468006301 agmatinase; Region: agmatinase; TIGR01230 446468006302 oligomer interface [polypeptide binding]; other site 446468006303 putative active site [active] 446468006304 Mn binding site [ion binding]; other site 446468006305 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468006306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468006307 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468006308 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468006309 Probable transposase; Region: OrfB_IS605; pfam01385 446468006310 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468006311 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 446468006312 Amidinotransferase; Region: Amidinotransf; cl12043 446468006313 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 446468006314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468006315 Cellulose binding domain; Region: CBM_2; pfam00553 446468006316 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 446468006317 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 446468006318 DNA binding site [nucleotide binding] 446468006319 heterodimer interface [polypeptide binding]; other site 446468006320 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 446468006321 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446468006322 NAD binding site [chemical binding]; other site 446468006323 catalytic Zn binding site [ion binding]; other site 446468006324 substrate binding site [chemical binding]; other site 446468006325 structural Zn binding site [ion binding]; other site 446468006326 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 446468006327 FAD binding domain; Region: FAD_binding_2; pfam00890 446468006328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 446468006329 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 446468006330 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446468006331 Uncharacterized conserved protein [Function unknown]; Region: COG3402 446468006332 Bacterial PH domain; Region: DUF304; pfam03703 446468006333 Bacterial PH domain; Region: DUF304; pfam03703 446468006334 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446468006335 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468006336 anti sigma factor interaction site; other site 446468006337 regulatory phosphorylation site [posttranslational modification]; other site 446468006338 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468006339 nudix motif; other site 446468006340 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 446468006341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006342 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468006343 putative substrate translocation pore; other site 446468006344 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 446468006345 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446468006346 NAD binding site [chemical binding]; other site 446468006347 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 446468006348 active site 446468006349 catalytic residues [active] 446468006350 metal binding site [ion binding]; metal-binding site 446468006351 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 446468006352 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468006353 dimerization interface [polypeptide binding]; other site 446468006354 putative DNA binding site [nucleotide binding]; other site 446468006355 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468006356 putative Zn2+ binding site [ion binding]; other site 446468006357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006358 Phosphotransferase enzyme family; Region: APH; pfam01636 446468006359 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468006360 active site 446468006361 ATP binding site [chemical binding]; other site 446468006362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468006363 S-adenosylmethionine binding site [chemical binding]; other site 446468006364 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 446468006365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468006366 S-adenosylmethionine binding site [chemical binding]; other site 446468006367 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468006368 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 446468006369 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 446468006370 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 446468006371 catalytic site [active] 446468006372 active site 446468006373 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 446468006374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468006375 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 446468006376 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 446468006377 active site 446468006378 catalytic site [active] 446468006379 PBP superfamily domain; Region: PBP_like_2; cl17296 446468006380 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446468006381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468006382 active site 446468006383 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468006384 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468006385 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468006386 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 446468006387 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468006388 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446468006389 active site 446468006390 catalytic site [active] 446468006391 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 446468006392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006393 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468006394 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468006395 active site 446468006396 SNF2 Helicase protein; Region: DUF3670; pfam12419 446468006397 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 446468006398 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468006399 ATP binding site [chemical binding]; other site 446468006400 putative Mg++ binding site [ion binding]; other site 446468006401 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446468006402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468006403 nucleotide binding region [chemical binding]; other site 446468006404 ATP-binding site [chemical binding]; other site 446468006405 Uncharacterized conserved protein [Function unknown]; Region: COG4279 446468006406 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468006407 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 446468006408 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468006409 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446468006410 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468006411 Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit [Lipid metabolism]; Region: AtoA; COG2057 446468006412 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 446468006413 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 446468006414 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468006415 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468006416 CGNR zinc finger; Region: zf-CGNR; pfam11706 446468006417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 446468006418 ACT domain; Region: ACT_3; pfam10000 446468006419 Family description; Region: ACT_7; pfam13840 446468006420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468006421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468006422 active site 446468006423 catalytic tetrad [active] 446468006424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468006425 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468006426 active site 446468006427 catalytic tetrad [active] 446468006428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468006429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468006430 Coenzyme A binding pocket [chemical binding]; other site 446468006431 maltodextrin glucosidase; Provisional; Region: PRK10785 446468006432 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 446468006433 homodimer interface [polypeptide binding]; other site 446468006434 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 446468006435 active site 446468006436 homodimer interface [polypeptide binding]; other site 446468006437 catalytic site [active] 446468006438 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 446468006439 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468006440 Domain of unknown function (DUF718); Region: DUF718; pfam05336 446468006441 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 446468006442 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 446468006443 ligand binding site [chemical binding]; other site 446468006444 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468006445 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468006446 TM-ABC transporter signature motif; other site 446468006447 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468006448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468006449 TM-ABC transporter signature motif; other site 446468006450 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446468006451 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468006452 Walker A/P-loop; other site 446468006453 ATP binding site [chemical binding]; other site 446468006454 Q-loop/lid; other site 446468006455 ABC transporter signature motif; other site 446468006456 Walker B; other site 446468006457 D-loop; other site 446468006458 H-loop/switch region; other site 446468006459 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446468006460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468006461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468006462 DNA binding site [nucleotide binding] 446468006463 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468006464 ligand binding site [chemical binding]; other site 446468006465 dimerization interface [polypeptide binding]; other site 446468006466 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 446468006467 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468006468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468006469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468006470 non-specific DNA binding site [nucleotide binding]; other site 446468006471 salt bridge; other site 446468006472 sequence-specific DNA binding site [nucleotide binding]; other site 446468006473 Predicted ATPase [General function prediction only]; Region: COG4637 446468006474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468006475 Walker A/P-loop; other site 446468006476 ATP binding site [chemical binding]; other site 446468006477 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 446468006478 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468006479 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468006480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468006482 putative substrate translocation pore; other site 446468006483 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 446468006484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468006485 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468006486 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468006487 intersubunit interface [polypeptide binding]; other site 446468006488 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468006489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006490 ABC-ATPase subunit interface; other site 446468006491 dimer interface [polypeptide binding]; other site 446468006492 putative PBP binding regions; other site 446468006493 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006494 ABC-ATPase subunit interface; other site 446468006495 dimer interface [polypeptide binding]; other site 446468006496 putative PBP binding regions; other site 446468006497 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468006498 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468006499 Walker A/P-loop; other site 446468006500 ATP binding site [chemical binding]; other site 446468006501 Q-loop/lid; other site 446468006502 ABC transporter signature motif; other site 446468006503 Walker B; other site 446468006504 D-loop; other site 446468006505 H-loop/switch region; other site 446468006506 Trehalose utilisation; Region: ThuA; pfam06283 446468006507 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446468006508 FOG: PKD repeat [General function prediction only]; Region: COG3291 446468006509 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 446468006510 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 446468006511 metal binding site [ion binding]; metal-binding site 446468006512 ligand binding site [chemical binding]; other site 446468006513 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 446468006514 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 446468006515 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 446468006516 UbiA prenyltransferase family; Region: UbiA; pfam01040 446468006517 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 446468006518 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446468006519 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 446468006520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468006521 active site 446468006522 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446468006523 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 446468006524 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 446468006525 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446468006526 intersubunit interface [polypeptide binding]; other site 446468006527 active site 446468006528 Zn2+ binding site [ion binding]; other site 446468006529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446468006530 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446468006531 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468006532 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 446468006533 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468006534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468006535 DNA-binding site [nucleotide binding]; DNA binding site 446468006536 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468006537 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446468006538 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468006539 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468006540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468006541 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468006542 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 446468006543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468006544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468006545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468006546 DNA binding site [nucleotide binding] 446468006547 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446468006548 putative ligand binding site [chemical binding]; other site 446468006549 putative dimerization interface [polypeptide binding]; other site 446468006550 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468006551 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468006552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468006553 dimer interface [polypeptide binding]; other site 446468006554 conserved gate region; other site 446468006555 putative PBP binding loops; other site 446468006556 ABC-ATPase subunit interface; other site 446468006557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468006558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468006559 dimer interface [polypeptide binding]; other site 446468006560 conserved gate region; other site 446468006561 putative PBP binding loops; other site 446468006562 ABC-ATPase subunit interface; other site 446468006563 Gas vesicle protein K; Region: GvpK; pfam05121 446468006564 Gas vesicle protein; Region: Gas_vesicle; pfam00741 446468006565 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 446468006566 Gas vesicle protein; Region: Gas_vesicle; pfam00741 446468006567 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 446468006568 putative hydrophobic ligand binding site [chemical binding]; other site 446468006569 Gas vesicle protein G; Region: GvpG; pfam05120 446468006570 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 446468006571 gas vesicle synthesis-like protein; Reviewed; Region: PRK09368 446468006572 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 446468006573 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 446468006574 intersubunit interface [polypeptide binding]; other site 446468006575 active site 446468006576 zinc binding site [ion binding]; other site 446468006577 Na+ binding site [ion binding]; other site 446468006578 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446468006579 putative substrate binding site [chemical binding]; other site 446468006580 putative ATP binding site [chemical binding]; other site 446468006581 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468006582 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468006583 nucleotide binding site [chemical binding]; other site 446468006584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468006585 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446468006586 dimer interface [polypeptide binding]; other site 446468006587 active site 446468006588 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446468006589 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468006590 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 446468006591 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468006592 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 446468006593 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 446468006594 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 446468006595 active site 446468006596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468006597 putative PBP binding loops; other site 446468006598 ABC-ATPase subunit interface; other site 446468006599 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468006600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468006601 dimer interface [polypeptide binding]; other site 446468006602 conserved gate region; other site 446468006603 putative PBP binding loops; other site 446468006604 ABC-ATPase subunit interface; other site 446468006605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468006606 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468006607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468006608 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468006609 sequence-specific DNA binding site [nucleotide binding]; other site 446468006610 salt bridge; other site 446468006611 short chain dehydrogenase; Provisional; Region: PRK05854 446468006612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006613 NAD(P) binding site [chemical binding]; other site 446468006614 active site 446468006615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006616 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468006617 putative substrate translocation pore; other site 446468006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006619 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 446468006620 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446468006621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468006622 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446468006623 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446468006624 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 446468006625 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468006626 Leucine carboxyl methyltransferase; Region: LCM; cl01306 446468006627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468006628 salt bridge; other site 446468006629 non-specific DNA binding site [nucleotide binding]; other site 446468006630 sequence-specific DNA binding site [nucleotide binding]; other site 446468006631 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 446468006632 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 446468006633 N- and C-terminal domain interface [polypeptide binding]; other site 446468006634 active site 446468006635 ATP binding site [chemical binding]; other site 446468006636 carbohydrate binding site [chemical binding]; other site 446468006637 short chain dehydrogenase; Validated; Region: PRK08324 446468006638 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 446468006639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006640 NAD(P) binding site [chemical binding]; other site 446468006641 active site 446468006642 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 446468006643 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 446468006644 LysE type translocator; Region: LysE; cl00565 446468006645 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 446468006646 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468006647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468006648 dimerization interface [polypeptide binding]; other site 446468006649 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446468006650 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 446468006651 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446468006652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468006653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468006654 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446468006655 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446468006656 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446468006657 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 446468006658 putative active site [active] 446468006659 catalytic site [active] 446468006660 putative metal binding site [ion binding]; other site 446468006661 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446468006662 amidase catalytic site [active] 446468006663 Zn binding residues [ion binding]; other site 446468006664 substrate binding site [chemical binding]; other site 446468006665 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468006666 MarR family; Region: MarR_2; pfam12802 446468006667 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 446468006668 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 446468006669 NAD binding site [chemical binding]; other site 446468006670 catalytic Zn binding site [ion binding]; other site 446468006671 substrate binding site [chemical binding]; other site 446468006672 structural Zn binding site [ion binding]; other site 446468006673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468006674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006675 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468006676 putative substrate translocation pore; other site 446468006677 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 446468006678 A new structural DNA glycosylase; Region: AlkD_like; cd06561 446468006679 active site 446468006680 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446468006681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468006682 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468006683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468006684 DNA binding residues [nucleotide binding] 446468006685 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446468006686 Cation efflux family; Region: Cation_efflux; pfam01545 446468006687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468006688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468006689 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468006690 CAAX protease self-immunity; Region: Abi; pfam02517 446468006691 acyl-CoA synthetase; Validated; Region: PRK08316 446468006692 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468006693 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 446468006694 acyl-activating enzyme (AAE) consensus motif; other site 446468006695 acyl-activating enzyme (AAE) consensus motif; other site 446468006696 putative AMP binding site [chemical binding]; other site 446468006697 putative active site [active] 446468006698 putative CoA binding site [chemical binding]; other site 446468006699 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468006700 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468006701 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 446468006702 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446468006703 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446468006704 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446468006705 DNA binding site [nucleotide binding] 446468006706 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468006707 AAA ATPase domain; Region: AAA_16; pfam13191 446468006708 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468006709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006710 NAD(P) binding site [chemical binding]; other site 446468006711 active site 446468006712 Predicted transcriptional regulators [Transcription]; Region: COG1733 446468006713 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446468006714 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446468006715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468006716 NAD(P) binding site [chemical binding]; other site 446468006717 active site 446468006718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468006719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468006720 salt bridge; other site 446468006721 non-specific DNA binding site [nucleotide binding]; other site 446468006722 sequence-specific DNA binding site [nucleotide binding]; other site 446468006723 GTP cyclohydrolase I; Provisional; Region: PLN03044 446468006724 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 446468006725 active site 446468006726 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 446468006727 Ligand Binding Site [chemical binding]; other site 446468006728 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468006729 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468006730 DNA binding residues [nucleotide binding] 446468006731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468006732 S-adenosylmethionine binding site [chemical binding]; other site 446468006733 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 446468006734 active site 446468006735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468006737 putative substrate translocation pore; other site 446468006738 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 446468006739 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 446468006740 dimer interface [polypeptide binding]; other site 446468006741 active site 446468006742 metal binding site [ion binding]; metal-binding site 446468006743 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 446468006744 proline aminopeptidase P II; Provisional; Region: PRK10879 446468006745 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 446468006746 active site 446468006747 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 446468006748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468006749 Coenzyme A binding pocket [chemical binding]; other site 446468006750 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446468006751 SnoaL-like domain; Region: SnoaL_2; pfam12680 446468006752 Cupin domain; Region: Cupin_2; cl17218 446468006753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468006754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468006755 active site 446468006756 phosphorylation site [posttranslational modification] 446468006757 intermolecular recognition site; other site 446468006758 dimerization interface [polypeptide binding]; other site 446468006759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468006760 DNA binding residues [nucleotide binding] 446468006761 dimerization interface [polypeptide binding]; other site 446468006762 Putative sensor; Region: Sensor; pfam13796 446468006763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468006764 Histidine kinase; Region: HisKA_3; pfam07730 446468006765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468006766 ATP binding site [chemical binding]; other site 446468006767 Mg2+ binding site [ion binding]; other site 446468006768 G-X-G motif; other site 446468006769 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 446468006770 adenylosuccinate lyase; Region: purB; TIGR00928 446468006771 tetramer interface [polypeptide binding]; other site 446468006772 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 446468006773 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 446468006774 tetramer interface [polypeptide binding]; other site 446468006775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468006776 catalytic residue [active] 446468006777 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446468006778 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468006779 intersubunit interface [polypeptide binding]; other site 446468006780 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446468006781 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006782 ABC-ATPase subunit interface; other site 446468006783 putative PBP binding regions; other site 446468006784 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006785 dimer interface [polypeptide binding]; other site 446468006786 ABC-ATPase subunit interface; other site 446468006787 putative PBP binding regions; other site 446468006788 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468006789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468006790 Domain of unknown function (DUF364); Region: DUF364; pfam04016 446468006791 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446468006792 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468006793 catalytic residue [active] 446468006794 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 446468006795 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446468006796 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446468006797 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446468006798 Cellulose binding domain; Region: CBM_2; pfam00553 446468006799 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446468006800 Cellulose binding domain; Region: CBM_2; pfam00553 446468006801 Cellulose binding domain; Region: CBM_2; pfam00553 446468006802 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 446468006803 Cellulose binding domain; Region: CBM_2; pfam00553 446468006804 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446468006805 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 446468006806 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468006807 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446468006808 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 446468006809 NADP binding site [chemical binding]; other site 446468006810 substrate binding site [chemical binding]; other site 446468006811 active site 446468006812 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468006813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468006814 dimerization interface [polypeptide binding]; other site 446468006815 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 446468006816 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 446468006817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446468006818 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468006819 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468006820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468006821 putative DNA binding site [nucleotide binding]; other site 446468006822 putative Zn2+ binding site [ion binding]; other site 446468006823 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468006824 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 446468006825 Dak1 domain; Region: Dak1; pfam02733 446468006826 DAK2 domain; Region: Dak2; pfam02734 446468006827 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 446468006828 inhibitor binding site; inhibition site 446468006829 active site 446468006830 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468006831 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468006832 active site 446468006833 Uncharacterized conserved protein [Function unknown]; Region: COG1359 446468006834 Peptidase_C39 like family; Region: DUF3335; pfam11814 446468006835 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468006836 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 446468006837 ABC-ATPase subunit interface; other site 446468006838 dimer interface [polypeptide binding]; other site 446468006839 putative PBP binding regions; other site 446468006840 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468006841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468006842 ABC-ATPase subunit interface; other site 446468006843 dimer interface [polypeptide binding]; other site 446468006844 putative PBP binding regions; other site 446468006845 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446468006846 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468006847 siderophore binding site; other site 446468006848 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468006849 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468006850 Walker A/P-loop; other site 446468006851 ATP binding site [chemical binding]; other site 446468006852 Q-loop/lid; other site 446468006853 ABC transporter signature motif; other site 446468006854 Walker B; other site 446468006855 D-loop; other site 446468006856 H-loop/switch region; other site 446468006857 Cupin domain; Region: Cupin_2; cl17218 446468006858 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 446468006859 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468006860 BCCT family transporter; Region: BCCT; pfam02028 446468006861 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 446468006862 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468006863 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468006864 hypothetical protein; Provisional; Region: PRK08204 446468006865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468006866 active site 446468006867 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468006868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468006869 DNA binding site [nucleotide binding] 446468006870 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468006871 dimerization interface [polypeptide binding]; other site 446468006872 ligand binding site [chemical binding]; other site 446468006873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468006874 putative substrate translocation pore; other site 446468006875 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468006876 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468006877 active site 446468006878 ATP binding site [chemical binding]; other site 446468006879 substrate binding site [chemical binding]; other site 446468006880 activation loop (A-loop); other site 446468006881 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446468006882 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446468006883 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446468006884 CoenzymeA binding site [chemical binding]; other site 446468006885 subunit interaction site [polypeptide binding]; other site 446468006886 PHB binding site; other site 446468006887 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 446468006888 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 446468006889 FAD binding pocket [chemical binding]; other site 446468006890 FAD binding motif [chemical binding]; other site 446468006891 phosphate binding motif [ion binding]; other site 446468006892 beta-alpha-beta structure motif; other site 446468006893 NAD(p) ribose binding residues [chemical binding]; other site 446468006894 NAD binding pocket [chemical binding]; other site 446468006895 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 446468006896 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446468006897 catalytic loop [active] 446468006898 iron binding site [ion binding]; other site 446468006899 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 446468006900 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446468006901 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 446468006902 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 446468006903 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 446468006904 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 446468006905 enoyl-CoA hydratase; Provisional; Region: PRK06688 446468006906 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468006907 substrate binding site [chemical binding]; other site 446468006908 oxyanion hole (OAH) forming residues; other site 446468006909 trimer interface [polypeptide binding]; other site 446468006910 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 446468006911 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446468006912 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446468006913 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468006914 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468006915 substrate binding site [chemical binding]; other site 446468006916 oxyanion hole (OAH) forming residues; other site 446468006917 trimer interface [polypeptide binding]; other site 446468006918 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 446468006919 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446468006920 dimer interface [polypeptide binding]; other site 446468006921 active site 446468006922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468006923 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 446468006924 acyl-activating enzyme (AAE) consensus motif; other site 446468006925 AMP binding site [chemical binding]; other site 446468006926 active site 446468006927 CoA binding site [chemical binding]; other site 446468006928 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446468006929 active site 446468006930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468006931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468006932 active site 446468006933 phosphorylation site [posttranslational modification] 446468006934 intermolecular recognition site; other site 446468006935 dimerization interface [polypeptide binding]; other site 446468006936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468006937 dimerization interface [polypeptide binding]; other site 446468006938 DNA binding residues [nucleotide binding] 446468006939 Histidine kinase; Region: HisKA_3; pfam07730 446468006940 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468006941 Mg2+ binding site [ion binding]; other site 446468006942 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446468006943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468006944 Walker A/P-loop; other site 446468006945 ATP binding site [chemical binding]; other site 446468006946 Q-loop/lid; other site 446468006947 ABC transporter signature motif; other site 446468006948 Walker B; other site 446468006949 D-loop; other site 446468006950 H-loop/switch region; other site 446468006951 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 446468006952 putative active site [active] 446468006953 putative metal binding residues [ion binding]; other site 446468006954 signature motif; other site 446468006955 putative triphosphate binding site [ion binding]; other site 446468006956 dimer interface [polypeptide binding]; other site 446468006957 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 446468006958 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 446468006959 active site 446468006960 tetramer interface [polypeptide binding]; other site 446468006961 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446468006962 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 446468006963 dimer interface [polypeptide binding]; other site 446468006964 NADP binding site [chemical binding]; other site 446468006965 catalytic residues [active] 446468006966 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 446468006967 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446468006968 putative active site [active] 446468006969 catalytic residue [active] 446468006970 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468006971 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 446468006972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 446468006973 dimerization interface [polypeptide binding]; other site 446468006974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 446468006975 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 446468006976 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 446468006977 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468006978 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468006979 active site 446468006980 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 446468006981 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446468006982 PYR/PP interface [polypeptide binding]; other site 446468006983 dimer interface [polypeptide binding]; other site 446468006984 TPP binding site [chemical binding]; other site 446468006985 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468006986 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446468006987 TPP-binding site [chemical binding]; other site 446468006988 dimer interface [polypeptide binding]; other site 446468006989 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468006990 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468006991 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446468006992 TrkA-N domain; Region: TrkA_N; pfam02254 446468006993 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468006994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468006995 DNA-binding site [nucleotide binding]; DNA binding site 446468006996 FCD domain; Region: FCD; pfam07729 446468006997 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 446468006998 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 446468006999 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 446468007000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468007001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468007002 DNA binding site [nucleotide binding] 446468007003 domain linker motif; other site 446468007004 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468007005 ligand binding site [chemical binding]; other site 446468007006 dimerization interface [polypeptide binding]; other site 446468007007 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 446468007008 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468007009 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 446468007010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468007011 salt bridge; other site 446468007012 non-specific DNA binding site [nucleotide binding]; other site 446468007013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468007014 sequence-specific DNA binding site [nucleotide binding]; other site 446468007015 short chain dehydrogenase; Provisional; Region: PRK08219 446468007016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468007017 NAD(P) binding site [chemical binding]; other site 446468007018 active site 446468007019 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007020 active site 446468007021 conformational flexibility of ligand binding pocket; other site 446468007022 ADP-ribosylating toxin turn-turn motif; other site 446468007023 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007024 active site 446468007025 ADP-ribosylating toxin turn-turn motif; other site 446468007026 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007027 active site 446468007028 conformational flexibility of ligand binding pocket; other site 446468007029 ADP-ribosylating toxin turn-turn motif; other site 446468007030 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007031 active site 446468007032 ADP-ribosylating toxin turn-turn motif; other site 446468007033 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007034 active site 446468007035 ADP-ribosylating toxin turn-turn motif; other site 446468007036 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007037 active site 446468007038 conformational flexibility of ligand binding pocket; other site 446468007039 ADP-ribosylating toxin turn-turn motif; other site 446468007040 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 446468007041 active site 446468007042 ADP-ribosylating toxin turn-turn motif; other site 446468007043 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468007044 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446468007045 beta-galactosidase; Region: BGL; TIGR03356 446468007046 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 446468007047 O-methyltransferase; Region: Methyltransf_2; pfam00891 446468007048 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 446468007049 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 446468007050 oligomer interface [polypeptide binding]; other site 446468007051 metal binding site [ion binding]; metal-binding site 446468007052 metal binding site [ion binding]; metal-binding site 446468007053 putative Cl binding site [ion binding]; other site 446468007054 basic sphincter; other site 446468007055 hydrophobic gate; other site 446468007056 periplasmic entrance; other site 446468007057 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 446468007058 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 446468007059 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468007060 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446468007061 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446468007062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468007063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468007064 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446468007065 putative dimerization interface [polypeptide binding]; other site 446468007066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468007067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468007068 putative DNA binding site [nucleotide binding]; other site 446468007069 putative Zn2+ binding site [ion binding]; other site 446468007070 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 446468007071 putative dimerization interface [polypeptide binding]; other site 446468007072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468007073 Coenzyme A binding pocket [chemical binding]; other site 446468007074 Predicted membrane protein [Function unknown]; Region: COG1289 446468007075 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 446468007076 Putative cyclase; Region: Cyclase; cl00814 446468007077 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446468007078 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446468007079 putative acyl-acceptor binding pocket; other site 446468007080 ferredoxin-NADP+ reductase; Region: PLN02852 446468007081 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468007082 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446468007083 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446468007084 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446468007085 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 446468007086 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 446468007087 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 446468007088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468007089 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446468007090 Walker A/P-loop; other site 446468007091 ATP binding site [chemical binding]; other site 446468007092 Q-loop/lid; other site 446468007093 ABC transporter signature motif; other site 446468007094 Walker B; other site 446468007095 D-loop; other site 446468007096 H-loop/switch region; other site 446468007097 TOBE domain; Region: TOBE; cl01440 446468007098 sulfate transport protein; Provisional; Region: cysT; CHL00187 446468007099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468007100 putative PBP binding loops; other site 446468007101 ABC-ATPase subunit interface; other site 446468007102 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 446468007103 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 446468007104 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468007105 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468007106 DNA binding residues [nucleotide binding] 446468007107 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 446468007108 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 446468007109 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 446468007110 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446468007111 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 446468007112 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 446468007113 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 446468007114 dimer interface [polypeptide binding]; other site 446468007115 tetramer interface [polypeptide binding]; other site 446468007116 PYR/PP interface [polypeptide binding]; other site 446468007117 TPP binding site [chemical binding]; other site 446468007118 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446468007119 TPP-binding site [chemical binding]; other site 446468007120 O-succinylbenzoate synthase; Provisional; Region: PRK02901 446468007121 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 446468007122 active site 446468007123 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468007124 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 446468007125 substrate binding site [chemical binding]; other site 446468007126 oxyanion hole (OAH) forming residues; other site 446468007127 trimer interface [polypeptide binding]; other site 446468007128 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468007129 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 446468007130 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468007131 acyl-activating enzyme (AAE) consensus motif; other site 446468007132 acyl-activating enzyme (AAE) consensus motif; other site 446468007133 AMP binding site [chemical binding]; other site 446468007134 active site 446468007135 CoA binding site [chemical binding]; other site 446468007136 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446468007137 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446468007138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468007139 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468007140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468007141 DNA binding residues [nucleotide binding] 446468007142 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 446468007143 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 446468007144 Predicted transcriptional regulators [Transcription]; Region: COG1725 446468007145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468007146 DNA-binding site [nucleotide binding]; DNA binding site 446468007147 SpoOM protein; Region: Spo0M; pfam07070 446468007148 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 446468007149 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 446468007150 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468007151 Walker A/P-loop; other site 446468007152 ATP binding site [chemical binding]; other site 446468007153 Q-loop/lid; other site 446468007154 ABC transporter signature motif; other site 446468007155 Walker B; other site 446468007156 D-loop; other site 446468007157 H-loop/switch region; other site 446468007158 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468007159 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468007160 Walker A/P-loop; other site 446468007161 ATP binding site [chemical binding]; other site 446468007162 Q-loop/lid; other site 446468007163 ABC transporter signature motif; other site 446468007164 Walker B; other site 446468007165 D-loop; other site 446468007166 H-loop/switch region; other site 446468007167 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468007168 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468007169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468007170 dimer interface [polypeptide binding]; other site 446468007171 conserved gate region; other site 446468007172 putative PBP binding loops; other site 446468007173 ABC-ATPase subunit interface; other site 446468007174 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468007175 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468007176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468007177 non-specific DNA binding site [nucleotide binding]; other site 446468007178 salt bridge; other site 446468007179 sequence-specific DNA binding site [nucleotide binding]; other site 446468007180 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468007181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468007182 Mg2+ binding site [ion binding]; other site 446468007183 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468007184 DNA binding residues [nucleotide binding] 446468007185 B12 binding domain; Region: B12-binding_2; pfam02607 446468007186 B12 binding domain; Region: B12-binding; pfam02310 446468007187 B12 binding site [chemical binding]; other site 446468007188 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468007189 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 446468007190 peptide binding site [polypeptide binding]; other site 446468007191 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468007192 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468007193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468007194 dimer interface [polypeptide binding]; other site 446468007195 conserved gate region; other site 446468007196 putative PBP binding loops; other site 446468007197 ABC-ATPase subunit interface; other site 446468007198 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468007199 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007201 ABC transporter; Region: ABC_tran_2; pfam12848 446468007202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007203 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 446468007204 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 446468007205 active site 446468007206 dimer interface [polypeptide binding]; other site 446468007207 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 446468007208 dimer interface [polypeptide binding]; other site 446468007209 active site 446468007210 Ion transport protein; Region: Ion_trans; pfam00520 446468007211 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468007212 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468007213 DNA-binding site [nucleotide binding]; DNA binding site 446468007214 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468007215 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446468007216 Cysteine-rich domain; Region: CCG; pfam02754 446468007217 Cysteine-rich domain; Region: CCG; pfam02754 446468007218 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 446468007219 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 446468007220 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 446468007221 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 446468007222 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 446468007223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468007224 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 446468007225 RNA ligase; Region: RNA_ligase; pfam09414 446468007226 AAA domain; Region: AAA_33; pfam13671 446468007227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468007228 Coenzyme A binding pocket [chemical binding]; other site 446468007229 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446468007230 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468007231 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 446468007232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468007233 trimer interface [polypeptide binding]; other site 446468007234 oxyanion hole (OAH) forming residues; other site 446468007235 transcriptional regulator NanR; Provisional; Region: PRK03837 446468007236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468007237 DNA-binding site [nucleotide binding]; DNA binding site 446468007238 FCD domain; Region: FCD; pfam07729 446468007239 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 446468007240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468007241 catalytic core [active] 446468007242 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446468007243 TIGR02680 family protein; Region: TIGR02680 446468007244 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 446468007245 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 446468007246 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 446468007247 Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786 446468007248 Predicted membrane protein [Function unknown]; Region: COG4270 446468007249 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468007250 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468007251 active site 446468007252 metal binding site [ion binding]; metal-binding site 446468007253 putative phosphoesterase; Region: acc_ester; TIGR03729 446468007254 isopentenyl-diphosphate delta-isomerase; Provisional; Region: PRK03759 446468007255 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 446468007256 nudix motif; other site 446468007257 tocopherol O-methyltransferase; Region: PLN02244 446468007258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468007259 S-adenosylmethionine binding site [chemical binding]; other site 446468007260 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 446468007261 substrate binding pocket [chemical binding]; other site 446468007262 substrate-Mg2+ binding site; other site 446468007263 aspartate-rich region 1; other site 446468007264 aspartate-rich region 2; other site 446468007265 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446468007266 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446468007267 ligand binding site [chemical binding]; other site 446468007268 flexible hinge region; other site 446468007269 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 446468007270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 446468007271 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 446468007272 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 446468007273 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468007274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468007275 DNA-binding site [nucleotide binding]; DNA binding site 446468007276 UTRA domain; Region: UTRA; pfam07702 446468007277 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 446468007278 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 446468007279 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468007280 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446468007281 Walker A/P-loop; other site 446468007282 ATP binding site [chemical binding]; other site 446468007283 Q-loop/lid; other site 446468007284 ABC transporter signature motif; other site 446468007285 Walker B; other site 446468007286 D-loop; other site 446468007287 H-loop/switch region; other site 446468007288 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 446468007289 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468007290 binding surface 446468007291 TPR motif; other site 446468007292 TPR repeat; Region: TPR_11; pfam13414 446468007293 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468007294 binding surface 446468007295 TPR motif; other site 446468007296 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468007297 classical (c) SDRs; Region: SDR_c; cd05233 446468007298 NAD(P) binding site [chemical binding]; other site 446468007299 active site 446468007300 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468007301 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 446468007302 putative NAD(P) binding site [chemical binding]; other site 446468007303 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 446468007304 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446468007305 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446468007306 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468007307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468007308 PAS domain; Region: PAS_9; pfam13426 446468007309 putative active site [active] 446468007310 heme pocket [chemical binding]; other site 446468007311 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446468007312 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468007313 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468007314 anti sigma factor interaction site; other site 446468007315 regulatory phosphorylation site [posttranslational modification]; other site 446468007316 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 446468007317 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 446468007318 tetramer interface [polypeptide binding]; other site 446468007319 active site 446468007320 Mg2+/Mn2+ binding site [ion binding]; other site 446468007321 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 446468007322 SWIM zinc finger; Region: SWIM; pfam04434 446468007323 Transcriptional regulator; Region: Rrf2; pfam02082 446468007324 Rrf2 family protein; Region: rrf2_super; TIGR00738 446468007325 Transcriptional regulator; Region: Rrf2; cl17282 446468007326 SnoaL-like domain; Region: SnoaL_2; pfam12680 446468007327 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 446468007328 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446468007329 nudix motif; other site 446468007330 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468007331 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468007332 Walker A/P-loop; other site 446468007333 ATP binding site [chemical binding]; other site 446468007334 Q-loop/lid; other site 446468007335 ABC transporter signature motif; other site 446468007336 Walker B; other site 446468007337 D-loop; other site 446468007338 H-loop/switch region; other site 446468007339 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468007340 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468007341 ABC-ATPase subunit interface; other site 446468007342 dimer interface [polypeptide binding]; other site 446468007343 putative PBP binding regions; other site 446468007344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468007345 S-adenosylmethionine binding site [chemical binding]; other site 446468007346 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468007347 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446468007348 intersubunit interface [polypeptide binding]; other site 446468007349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468007350 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468007351 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468007352 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446468007353 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468007354 DNA binding residues [nucleotide binding] 446468007355 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 446468007356 RibD C-terminal domain; Region: RibD_C; cl17279 446468007357 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468007358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468007359 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468007360 putative substrate translocation pore; other site 446468007361 acetylornithine deacetylase; Provisional; Region: PRK06837 446468007362 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 446468007363 metal binding site [ion binding]; metal-binding site 446468007364 dimer interface [polypeptide binding]; other site 446468007365 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446468007366 catalytic residues [active] 446468007367 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468007368 nudix motif; other site 446468007369 BCCT family transporter; Region: BCCT; pfam02028 446468007370 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 446468007371 Protein of unknown function, DUF600; Region: DUF600; cl04640 446468007372 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468007374 binding surface 446468007375 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007376 TPR motif; other site 446468007377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468007378 binding surface 446468007379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007380 TPR motif; other site 446468007381 Hemerythrin-like domain; Region: Hr-like; cd12108 446468007382 Fe binding site [ion binding]; other site 446468007383 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446468007384 Part of AAA domain; Region: AAA_19; pfam13245 446468007385 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446468007386 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446468007387 ligand binding site [chemical binding]; other site 446468007388 flexible hinge region; other site 446468007389 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 446468007390 SEC-C motif; Region: SEC-C; pfam02810 446468007391 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 446468007392 MgtC family; Region: MgtC; pfam02308 446468007393 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 446468007394 HTH domain; Region: HTH_11; pfam08279 446468007395 WYL domain; Region: WYL; pfam13280 446468007396 Epoxide hydrolase N terminus; Region: EHN; pfam06441 446468007397 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468007398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468007399 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468007400 active site 446468007401 metal binding site [ion binding]; metal-binding site 446468007402 hypothetical protein; Provisional; Region: PRK04233 446468007403 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 446468007404 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468007405 active site 446468007406 ATP binding site [chemical binding]; other site 446468007407 substrate binding site [chemical binding]; other site 446468007408 activation loop (A-loop); other site 446468007409 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468007410 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468007411 active site 446468007412 ATP binding site [chemical binding]; other site 446468007413 substrate binding site [chemical binding]; other site 446468007414 activation loop (A-loop); other site 446468007415 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468007416 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468007417 active site 446468007418 ATP binding site [chemical binding]; other site 446468007419 substrate binding site [chemical binding]; other site 446468007420 activation loop (A-loop); other site 446468007421 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446468007422 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446468007423 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468007424 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468007425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468007426 salt bridge; other site 446468007427 non-specific DNA binding site [nucleotide binding]; other site 446468007428 sequence-specific DNA binding site [nucleotide binding]; other site 446468007429 Glucose dehydrogenase; Region: glucose_DH; cd08230 446468007430 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446468007431 NADP binding site [chemical binding]; other site 446468007432 catalytic Zn binding site [ion binding]; other site 446468007433 structural Zn binding site [ion binding]; other site 446468007434 dimer interface [polypeptide binding]; other site 446468007435 acyl-CoA synthetase; Validated; Region: PRK07787 446468007436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468007437 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468007438 acyl-activating enzyme (AAE) consensus motif; other site 446468007439 acyl-activating enzyme (AAE) consensus motif; other site 446468007440 AMP binding site [chemical binding]; other site 446468007441 active site 446468007442 CoA binding site [chemical binding]; other site 446468007443 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 446468007444 metal binding site 2 [ion binding]; metal-binding site 446468007445 putative DNA binding helix; other site 446468007446 metal binding site 1 [ion binding]; metal-binding site 446468007447 dimer interface [polypeptide binding]; other site 446468007448 structural Zn2+ binding site [ion binding]; other site 446468007449 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 446468007450 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 446468007451 tetramer interface [polypeptide binding]; other site 446468007452 heme binding pocket [chemical binding]; other site 446468007453 NADPH binding site [chemical binding]; other site 446468007454 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 446468007455 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 446468007456 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 446468007457 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 446468007458 CBD_II domain; Region: CBD_II; smart00637 446468007459 Rdx family; Region: Rdx; cl01407 446468007460 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468007461 Zn2+ binding site [ion binding]; other site 446468007462 Mg2+ binding site [ion binding]; other site 446468007463 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 446468007464 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 446468007465 putative metal binding site [ion binding]; other site 446468007466 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446468007467 active site 446468007468 Protein of unknown function (DUF419); Region: DUF419; pfam04237 446468007469 glycogen branching enzyme; Provisional; Region: PRK14705 446468007470 Caspase domain; Region: Peptidase_C14; pfam00656 446468007471 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 446468007472 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446468007473 amidase catalytic site [active] 446468007474 Zn binding residues [ion binding]; other site 446468007475 substrate binding site [chemical binding]; other site 446468007476 Predicted helicase [General function prediction only]; Region: COG4889 446468007477 Part of AAA domain; Region: AAA_19; pfam13245 446468007478 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 446468007479 AAA domain; Region: AAA_12; pfam13087 446468007480 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 446468007481 putative active site [active] 446468007482 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468007483 ATP binding site [chemical binding]; other site 446468007484 putative Mg++ binding site [ion binding]; other site 446468007485 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468007486 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 446468007487 nucleotide binding region [chemical binding]; other site 446468007488 ATP-binding site [chemical binding]; other site 446468007489 Methyltransferase domain; Region: Methyltransf_26; pfam13659 446468007490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468007491 ATP-binding site [chemical binding]; other site 446468007492 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446468007493 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 446468007494 PLD-like domain; Region: PLDc_2; pfam13091 446468007495 putative active site [active] 446468007496 catalytic site [active] 446468007497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468007498 S-adenosylmethionine binding site [chemical binding]; other site 446468007499 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468007500 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468007501 active site 446468007502 ATP binding site [chemical binding]; other site 446468007503 substrate binding site [chemical binding]; other site 446468007504 activation loop (A-loop); other site 446468007505 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446468007506 Part of AAA domain; Region: AAA_19; pfam13245 446468007507 Family description; Region: UvrD_C_2; pfam13538 446468007508 Uncharacterized conserved protein [Function unknown]; Region: COG1479 446468007509 Protein of unknown function DUF262; Region: DUF262; pfam03235 446468007510 Uncharacterized conserved protein [Function unknown]; Region: COG3472 446468007511 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446468007512 metal ion-dependent adhesion site (MIDAS); other site 446468007513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468007514 active site 446468007515 ATP binding site [chemical binding]; other site 446468007516 substrate binding site [chemical binding]; other site 446468007517 activation loop (A-loop); other site 446468007518 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 446468007519 active site 446468007520 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 446468007521 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 446468007522 Sodium Bile acid symporter family; Region: SBF; pfam01758 446468007523 Restriction endonuclease; Region: Mrr_cat; pfam04471 446468007524 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 446468007525 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468007526 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 446468007527 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468007528 hypothetical protein; Provisional; Region: PRK06834 446468007529 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468007530 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468007531 Walker A/P-loop; other site 446468007532 ATP binding site [chemical binding]; other site 446468007533 Q-loop/lid; other site 446468007534 ABC transporter signature motif; other site 446468007535 Walker B; other site 446468007536 D-loop; other site 446468007537 H-loop/switch region; other site 446468007538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468007540 Cytochrome P450; Region: p450; cl12078 446468007541 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468007542 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446468007543 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468007544 G1 box; other site 446468007545 GTP/Mg2+ binding site [chemical binding]; other site 446468007546 G2 box; other site 446468007547 Switch I region; other site 446468007548 G3 box; other site 446468007549 Switch II region; other site 446468007550 G5 box; other site 446468007551 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468007552 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 446468007553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468007554 ATP binding site [chemical binding]; other site 446468007555 Mg2+ binding site [ion binding]; other site 446468007556 G-X-G motif; other site 446468007557 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446468007558 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446468007559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468007560 active site 446468007561 motif I; other site 446468007562 motif II; other site 446468007563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468007564 conserved hypothetical protein; Region: TIGR03843 446468007565 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 446468007566 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 446468007567 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468007568 catalytic core [active] 446468007569 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468007570 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468007571 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468007572 active site 446468007573 catalytic tetrad [active] 446468007574 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468007575 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446468007576 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468007577 FAD binding domain; Region: FAD_binding_4; pfam01565 446468007578 Berberine and berberine like; Region: BBE; pfam08031 446468007579 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468007580 MarR family; Region: MarR_2; pfam12802 446468007581 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 446468007582 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468007583 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468007584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468007585 non-specific DNA binding site [nucleotide binding]; other site 446468007586 salt bridge; other site 446468007587 sequence-specific DNA binding site [nucleotide binding]; other site 446468007588 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468007589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468007590 Mg2+ binding site [ion binding]; other site 446468007591 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468007592 DNA binding residues [nucleotide binding] 446468007593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468007594 MarR family; Region: MarR_2; cl17246 446468007595 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468007596 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468007597 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468007598 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468007599 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 446468007600 classical (c) SDRs; Region: SDR_c; cd05233 446468007601 NAD(P) binding site [chemical binding]; other site 446468007602 active site 446468007603 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446468007604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468007605 NAD(P) binding site [chemical binding]; other site 446468007606 active site 446468007607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468007608 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 446468007609 NAD(P) binding site [chemical binding]; other site 446468007610 active site 446468007611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468007612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468007613 active site 446468007614 phosphorylation site [posttranslational modification] 446468007615 intermolecular recognition site; other site 446468007616 dimerization interface [polypeptide binding]; other site 446468007617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468007618 dimerization interface [polypeptide binding]; other site 446468007619 DNA binding residues [nucleotide binding] 446468007620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468007621 Predicted membrane protein (DUF2053); Region: DUF2053; pfam09767 446468007622 Histidine kinase; Region: HisKA_3; pfam07730 446468007623 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468007624 ATP binding site [chemical binding]; other site 446468007625 Mg2+ binding site [ion binding]; other site 446468007626 G-X-G motif; other site 446468007627 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468007628 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468007629 Walker A/P-loop; other site 446468007630 ATP binding site [chemical binding]; other site 446468007631 Q-loop/lid; other site 446468007632 ABC transporter signature motif; other site 446468007633 Walker B; other site 446468007634 D-loop; other site 446468007635 H-loop/switch region; other site 446468007636 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446468007637 FtsX-like permease family; Region: FtsX; pfam02687 446468007638 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 446468007639 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 446468007640 Ligand binding site; other site 446468007641 DXD motif; other site 446468007642 Putative Catalytic site; other site 446468007643 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468007644 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446468007645 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468007646 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 446468007647 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 446468007648 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468007649 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468007650 active site 446468007651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468007652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468007653 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 446468007654 dimerization interface [polypeptide binding]; other site 446468007655 substrate binding pocket [chemical binding]; other site 446468007656 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468007657 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446468007658 Uncharacterized conserved protein [Function unknown]; Region: COG0398 446468007659 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 446468007660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468007661 HAMP domain; Region: HAMP; pfam00672 446468007662 dimerization interface [polypeptide binding]; other site 446468007663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468007664 dimer interface [polypeptide binding]; other site 446468007665 phosphorylation site [posttranslational modification] 446468007666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468007667 ATP binding site [chemical binding]; other site 446468007668 Mg2+ binding site [ion binding]; other site 446468007669 G-X-G motif; other site 446468007670 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 446468007671 Predicted permease; Region: DUF318; cl17795 446468007672 Predicted permease; Region: DUF318; cl17795 446468007673 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446468007674 amino acid carrier protein; Region: agcS; TIGR00835 446468007675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468007676 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468007677 putative substrate translocation pore; other site 446468007678 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446468007679 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468007680 ATP binding site [chemical binding]; other site 446468007681 Mg++ binding site [ion binding]; other site 446468007682 motif III; other site 446468007683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468007684 nucleotide binding region [chemical binding]; other site 446468007685 ATP-binding site [chemical binding]; other site 446468007686 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468007687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468007688 substrate binding site [chemical binding]; other site 446468007689 oxyanion hole (OAH) forming residues; other site 446468007690 trimer interface [polypeptide binding]; other site 446468007691 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468007692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468007693 Walker A/P-loop; other site 446468007694 ATP binding site [chemical binding]; other site 446468007695 Q-loop/lid; other site 446468007696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468007698 Domain of unknown function DUF20; Region: UPF0118; pfam01594 446468007699 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 446468007700 hypothetical protein; Provisional; Region: PRK11770 446468007701 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446468007702 Domain of unknown function (DUF307); Region: DUF307; pfam03733 446468007703 Transcription factor WhiB; Region: Whib; pfam02467 446468007704 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468007705 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 446468007706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468007707 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468007708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468007709 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468007710 Protein of unknown function, DUF599; Region: DUF599; cl01575 446468007711 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 446468007712 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446468007713 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 446468007714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446468007715 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 446468007716 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 446468007717 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446468007718 Active Sites [active] 446468007719 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 446468007720 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 446468007721 putative active site [active] 446468007722 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 446468007723 putative active site [active] 446468007724 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 446468007725 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468007726 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446468007727 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 446468007728 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468007729 active site 446468007730 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 446468007731 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 446468007732 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 446468007733 active site 446468007734 catalytic site [active] 446468007735 hypothetical protein; Provisional; Region: PRK14059 446468007736 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 446468007737 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468007738 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468007739 DNA-binding site [nucleotide binding]; DNA binding site 446468007740 UTRA domain; Region: UTRA; pfam07702 446468007741 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 446468007742 SelR domain; Region: SelR; pfam01641 446468007743 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 446468007744 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 446468007745 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 446468007746 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 446468007747 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468007748 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 446468007749 Prefoldin subunit; Region: Prefoldin_2; pfam01920 446468007750 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 446468007751 substrate binding site [chemical binding]; other site 446468007752 active site 446468007753 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 446468007754 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 446468007755 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 446468007756 catalytic site [active] 446468007757 putative active site [active] 446468007758 putative substrate binding site [chemical binding]; other site 446468007759 HRDC domain; Region: HRDC; pfam00570 446468007760 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007761 Tetratricopeptide repeat; Region: TPR_10; cl17452 446468007762 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007763 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468007764 binding surface 446468007765 TPR motif; other site 446468007766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007767 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468007768 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446468007769 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 446468007770 dimer interface [polypeptide binding]; other site 446468007771 active site 446468007772 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468007773 substrate binding site [chemical binding]; other site 446468007774 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 446468007775 oxyanion hole (OAH) forming residues; other site 446468007776 trimer interface [polypeptide binding]; other site 446468007777 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 446468007778 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 446468007779 YrhK-like protein; Region: YrhK; pfam14145 446468007780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468007781 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468007782 MarR family; Region: MarR_2; pfam12802 446468007783 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 446468007784 Protein export membrane protein; Region: SecD_SecF; cl14618 446468007785 MMPL family; Region: MMPL; pfam03176 446468007786 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 446468007787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468007788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468007789 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446468007790 ferredoxin-NADP+ reductase; Region: PLN02852 446468007791 ferredoxin-NADP+ reductase; Region: PLN02852 446468007792 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 446468007793 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 446468007794 TPP-binding site; other site 446468007795 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446468007796 PYR/PP interface [polypeptide binding]; other site 446468007797 dimer interface [polypeptide binding]; other site 446468007798 TPP binding site [chemical binding]; other site 446468007799 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468007800 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 446468007801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468007802 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468007803 TM-ABC transporter signature motif; other site 446468007804 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468007805 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 446468007806 Walker A/P-loop; other site 446468007807 ATP binding site [chemical binding]; other site 446468007808 Q-loop/lid; other site 446468007809 ABC transporter signature motif; other site 446468007810 Walker B; other site 446468007811 D-loop; other site 446468007812 H-loop/switch region; other site 446468007813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468007814 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468007815 Probable transposase; Region: OrfB_IS605; pfam01385 446468007816 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468007817 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 446468007818 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468007819 MarR family; Region: MarR_2; pfam12802 446468007820 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468007821 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468007822 nucleotide binding site [chemical binding]; other site 446468007823 hypothetical protein; Provisional; Region: PRK06547 446468007824 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468007825 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468007826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468007827 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468007828 Ion channel; Region: Ion_trans_2; pfam07885 446468007829 Protein kinase domain; Region: Pkinase; pfam00069 446468007830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468007831 active site 446468007832 ATP binding site [chemical binding]; other site 446468007833 substrate binding site [chemical binding]; other site 446468007834 activation loop (A-loop); other site 446468007835 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 446468007836 putative hydrophobic ligand binding site [chemical binding]; other site 446468007837 aconitate hydratase; Validated; Region: PRK09277 446468007838 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 446468007839 substrate binding site [chemical binding]; other site 446468007840 ligand binding site [chemical binding]; other site 446468007841 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 446468007842 substrate binding site [chemical binding]; other site 446468007843 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446468007844 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468007845 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 446468007846 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468007847 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468007848 DNA binding residues [nucleotide binding] 446468007849 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468007850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468007851 Walker A/P-loop; other site 446468007852 ATP binding site [chemical binding]; other site 446468007853 Q-loop/lid; other site 446468007854 ABC transporter signature motif; other site 446468007855 Walker B; other site 446468007856 D-loop; other site 446468007857 H-loop/switch region; other site 446468007858 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 446468007859 TRAM domain; Region: TRAM; pfam01938 446468007860 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446468007861 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 446468007862 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446468007863 TrkA-N domain; Region: TrkA_N; pfam02254 446468007864 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 446468007865 TrkA-N domain; Region: TrkA_N; pfam02254 446468007866 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 446468007867 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 446468007868 reactive center loop; other site 446468007869 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 446468007870 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 446468007871 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446468007872 trimer interface [polypeptide binding]; other site 446468007873 active site 446468007874 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 446468007875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468007876 active site 446468007877 HIGH motif; other site 446468007878 nucleotide binding site [chemical binding]; other site 446468007879 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468007880 active site 446468007881 KMSKS motif; other site 446468007882 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 446468007883 tRNA binding surface [nucleotide binding]; other site 446468007884 anticodon binding site; other site 446468007885 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 446468007886 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 446468007887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468007888 dimerization interface [polypeptide binding]; other site 446468007889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468007890 dimer interface [polypeptide binding]; other site 446468007891 phosphorylation site [posttranslational modification] 446468007892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468007893 ATP binding site [chemical binding]; other site 446468007894 Mg2+ binding site [ion binding]; other site 446468007895 G-X-G motif; other site 446468007896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468007897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468007898 active site 446468007899 phosphorylation site [posttranslational modification] 446468007900 intermolecular recognition site; other site 446468007901 dimerization interface [polypeptide binding]; other site 446468007902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468007903 DNA binding site [nucleotide binding] 446468007904 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446468007905 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 446468007906 active site 446468007907 dimerization interface [polypeptide binding]; other site 446468007908 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468007909 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468007910 ferrochelatase; Reviewed; Region: hemH; PRK00035 446468007911 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 446468007912 C-terminal domain interface [polypeptide binding]; other site 446468007913 active site 446468007914 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 446468007915 active site 446468007916 N-terminal domain interface [polypeptide binding]; other site 446468007917 FAD binding domain; Region: FAD_binding_4; pfam01565 446468007918 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446468007919 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446468007920 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 446468007921 Bacterial PH domain; Region: DUF304; pfam03703 446468007922 Predicted membrane protein [Function unknown]; Region: COG3428 446468007923 Bacterial PH domain; Region: DUF304; cl01348 446468007924 Bacterial PH domain; Region: DUF304; cl01348 446468007925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468007926 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468007927 Probable transposase; Region: OrfB_IS605; pfam01385 446468007928 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468007930 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468007931 Walker A/P-loop; other site 446468007932 ATP binding site [chemical binding]; other site 446468007933 Q-loop/lid; other site 446468007934 ABC transporter signature motif; other site 446468007935 Walker B; other site 446468007936 D-loop; other site 446468007937 H-loop/switch region; other site 446468007938 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 446468007939 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468007940 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468007941 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468007942 Predicted ATPase [General function prediction only]; Region: COG3903 446468007943 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446468007944 substrate binding site [chemical binding]; other site 446468007945 Sec24-related protein; Provisional; Region: PTZ00395 446468007946 Sec24-related protein; Provisional; Region: PTZ00395 446468007947 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446468007948 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446468007949 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468007950 anti sigma factor interaction site; other site 446468007951 regulatory phosphorylation site [posttranslational modification]; other site 446468007952 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 446468007953 active site clefts [active] 446468007954 zinc binding site [ion binding]; other site 446468007955 dimer interface [polypeptide binding]; other site 446468007956 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 446468007957 Putative zinc ribbon domain; Region: DUF164; pfam02591 446468007958 Uncharacterized conserved protein [Function unknown]; Region: COG0327 446468007959 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 446468007960 HTH domain; Region: HTH_11; pfam08279 446468007961 WYL domain; Region: WYL; pfam13280 446468007962 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468007963 FAD binding domain; Region: FAD_binding_4; pfam01565 446468007964 Berberine and berberine like; Region: BBE; pfam08031 446468007965 AP endonuclease family 2; Region: AP2Ec; smart00518 446468007966 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 446468007967 AP (apurinic/apyrimidinic) site pocket; other site 446468007968 DNA interaction; other site 446468007969 Metal-binding active site; metal-binding site 446468007970 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468007971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468007972 dimerization interface [polypeptide binding]; other site 446468007973 putative DNA binding site [nucleotide binding]; other site 446468007974 putative Zn2+ binding site [ion binding]; other site 446468007975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468007976 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 446468007977 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 446468007978 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 446468007979 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 446468007980 RNA binding site [nucleotide binding]; other site 446468007981 Predicted acyl esterases [General function prediction only]; Region: COG2936 446468007982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468007983 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 446468007984 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468007985 Carboxylesterase family; Region: COesterase; pfam00135 446468007986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 446468007987 substrate binding pocket [chemical binding]; other site 446468007988 catalytic triad [active] 446468007989 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 446468007990 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468007991 NAD(P) binding site [chemical binding]; other site 446468007992 Predicted acetyltransferase [General function prediction only]; Region: COG2388 446468007993 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 446468007994 classical (c) SDRs; Region: SDR_c; cd05233 446468007995 NAD(P) binding site [chemical binding]; other site 446468007996 active site 446468007997 classical (c) SDRs; Region: SDR_c; cd05233 446468007998 NAD(P) binding site [chemical binding]; other site 446468007999 active site 446468008000 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 446468008001 putative active site [active] 446468008002 putative substrate binding site [chemical binding]; other site 446468008003 ATP binding site [chemical binding]; other site 446468008004 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468008005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468008006 active site 446468008007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468008008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468008009 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 446468008010 HD domain; Region: HD_4; pfam13328 446468008011 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 446468008012 putative dimer interface [polypeptide binding]; other site 446468008013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468008014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468008015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468008016 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468008017 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468008018 Walker A/P-loop; other site 446468008019 ATP binding site [chemical binding]; other site 446468008020 Q-loop/lid; other site 446468008021 ABC transporter signature motif; other site 446468008022 Walker B; other site 446468008023 D-loop; other site 446468008024 H-loop/switch region; other site 446468008025 FecCD transport family; Region: FecCD; pfam01032 446468008026 dimer interface [polypeptide binding]; other site 446468008027 putative PBP binding regions; other site 446468008028 ABC-ATPase subunit interface; other site 446468008029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468008030 ABC-ATPase subunit interface; other site 446468008031 dimer interface [polypeptide binding]; other site 446468008032 putative PBP binding regions; other site 446468008033 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 446468008034 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468008035 siderophore binding site; other site 446468008036 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446468008037 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 446468008038 Ca binding site [ion binding]; other site 446468008039 active site 446468008040 catalytic site [active] 446468008041 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 446468008042 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468008043 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446468008044 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446468008045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468008046 Walker A motif; other site 446468008047 ATP binding site [chemical binding]; other site 446468008048 Walker B motif; other site 446468008049 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446468008050 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446468008051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468008052 Walker A motif; other site 446468008053 ATP binding site [chemical binding]; other site 446468008054 Walker B motif; other site 446468008055 arginine finger; other site 446468008056 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446468008057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468008058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468008059 Amb_all domain; Region: Amb_all; smart00656 446468008060 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446468008061 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446468008062 putative sugar binding sites [chemical binding]; other site 446468008063 Q-X-W motif; other site 446468008064 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 446468008065 active site 446468008066 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 446468008067 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 446468008068 dimer interface [polypeptide binding]; other site 446468008069 catalytic triad [active] 446468008070 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 446468008071 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 446468008072 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 446468008073 putative active site [active] 446468008074 putative metal binding site [ion binding]; other site 446468008075 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468008076 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468008077 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 446468008078 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 446468008079 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446468008080 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446468008081 dimer interface [polypeptide binding]; other site 446468008082 active site 446468008083 CoA binding pocket [chemical binding]; other site 446468008084 acyl carrier protein; Provisional; Region: acpP; PRK00982 446468008085 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446468008086 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446468008087 dimer interface [polypeptide binding]; other site 446468008088 active site 446468008089 EAL domain; Region: EAL; pfam00563 446468008090 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 446468008091 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 446468008092 active site 446468008093 catalytic triad [active] 446468008094 oxyanion hole [active] 446468008095 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 446468008096 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 446468008097 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 446468008098 trimerization site [polypeptide binding]; other site 446468008099 active site 446468008100 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 446468008101 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 446468008102 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468008103 catalytic residue [active] 446468008104 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 446468008105 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 446468008106 Walker A/P-loop; other site 446468008107 ATP binding site [chemical binding]; other site 446468008108 Q-loop/lid; other site 446468008109 ABC transporter signature motif; other site 446468008110 Walker B; other site 446468008111 D-loop; other site 446468008112 H-loop/switch region; other site 446468008113 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 446468008114 [2Fe-2S] cluster binding site [ion binding]; other site 446468008115 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 446468008116 FeS assembly protein SufD; Region: sufD; TIGR01981 446468008117 FeS assembly protein SufB; Region: sufB; TIGR01980 446468008118 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 446468008119 Predicted transcriptional regulator [Transcription]; Region: COG2345 446468008120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468008121 putative DNA binding site [nucleotide binding]; other site 446468008122 putative Zn2+ binding site [ion binding]; other site 446468008123 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468008124 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468008125 Walker A/P-loop; other site 446468008126 ATP binding site [chemical binding]; other site 446468008127 Q-loop/lid; other site 446468008128 ABC transporter signature motif; other site 446468008129 Walker B; other site 446468008130 D-loop; other site 446468008131 H-loop/switch region; other site 446468008132 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468008133 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468008134 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 446468008135 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 446468008136 putative sugar binding sites [chemical binding]; other site 446468008137 Q-X-W motif; other site 446468008138 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 446468008139 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 446468008140 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 446468008141 Protease prsW family; Region: PrsW-protease; pfam13367 446468008142 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 446468008143 UbiA prenyltransferase family; Region: UbiA; pfam01040 446468008144 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 446468008145 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 446468008146 TPP-binding site [chemical binding]; other site 446468008147 dimer interface [polypeptide binding]; other site 446468008148 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446468008149 PYR/PP interface [polypeptide binding]; other site 446468008150 dimer interface [polypeptide binding]; other site 446468008151 TPP binding site [chemical binding]; other site 446468008152 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468008153 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 446468008154 putative active site [active] 446468008155 transaldolase; Provisional; Region: PRK03903 446468008156 catalytic residue [active] 446468008157 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446468008158 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446468008159 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446468008160 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 446468008161 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 446468008162 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 446468008163 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 446468008164 putative active site [active] 446468008165 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 446468008166 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468008167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 446468008168 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446468008169 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468008170 CRISPR-associated protein; Region: TIGR03986 446468008171 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 446468008172 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 446468008173 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446468008174 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446468008175 Na binding site [ion binding]; other site 446468008176 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446468008177 Lsr2; Region: Lsr2; pfam11774 446468008178 imidazolonepropionase; Provisional; Region: PRK14085 446468008179 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 446468008180 active site 446468008181 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 446468008182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468008183 active site 446468008184 allantoate amidohydrolase; Reviewed; Region: PRK09290 446468008185 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 446468008186 active site 446468008187 metal binding site [ion binding]; metal-binding site 446468008188 dimer interface [polypeptide binding]; other site 446468008189 urocanate hydratase; Provisional; Region: PRK05414 446468008190 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446468008191 active sites [active] 446468008192 tetramer interface [polypeptide binding]; other site 446468008193 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468008194 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 446468008195 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468008196 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 446468008197 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 446468008198 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 446468008199 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 446468008200 triosephosphate isomerase; Provisional; Region: PRK14567 446468008201 substrate binding site [chemical binding]; other site 446468008202 dimer interface [polypeptide binding]; other site 446468008203 catalytic triad [active] 446468008204 Phosphoglycerate kinase; Region: PGK; pfam00162 446468008205 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 446468008206 substrate binding site [chemical binding]; other site 446468008207 hinge regions; other site 446468008208 ADP binding site [chemical binding]; other site 446468008209 catalytic site [active] 446468008210 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 446468008211 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 446468008212 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 446468008213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 446468008214 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 446468008215 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 446468008216 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 446468008217 putative substrate binding pocket [chemical binding]; other site 446468008218 dimer interface [polypeptide binding]; other site 446468008219 phosphate binding site [ion binding]; other site 446468008220 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 446468008221 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 446468008222 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446468008223 GIY-YIG motif/motif A; other site 446468008224 active site 446468008225 catalytic site [active] 446468008226 putative DNA binding site [nucleotide binding]; other site 446468008227 metal binding site [ion binding]; metal-binding site 446468008228 UvrB/uvrC motif; Region: UVR; pfam02151 446468008229 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 446468008230 Helix-hairpin-helix motif; Region: HHH; pfam00633 446468008231 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 446468008232 Mechanosensitive ion channel; Region: MS_channel; pfam00924 446468008233 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446468008234 iron-sulfur cluster [ion binding]; other site 446468008235 [2Fe-2S] cluster binding site [ion binding]; other site 446468008236 RDD family; Region: RDD; pfam06271 446468008237 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 446468008238 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446468008239 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 446468008240 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 446468008241 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 446468008242 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468008243 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446468008244 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446468008245 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446468008246 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 446468008247 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 446468008248 Thiamine pyrophosphokinase; Region: TPK; cl08415 446468008249 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 446468008250 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 446468008251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008252 Walker A/P-loop; other site 446468008253 ATP binding site [chemical binding]; other site 446468008254 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 446468008255 ABC transporter signature motif; other site 446468008256 Walker B; other site 446468008257 D-loop; other site 446468008258 H-loop/switch region; other site 446468008259 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 446468008260 ATP-NAD kinase; Region: NAD_kinase; pfam01513 446468008261 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 446468008262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 446468008263 RNA binding surface [nucleotide binding]; other site 446468008264 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 446468008265 SCP-2 sterol transfer family; Region: SCP2; pfam02036 446468008266 Uncharacterized conserved protein [Function unknown]; Region: COG4198 446468008267 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 446468008268 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468008269 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468008270 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 446468008271 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 446468008272 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 446468008273 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446468008274 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446468008275 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468008276 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468008277 nudix motif; other site 446468008278 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 446468008279 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 446468008280 active site 446468008281 HIGH motif; other site 446468008282 dimer interface [polypeptide binding]; other site 446468008283 KMSKS motif; other site 446468008284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446468008285 RNA binding surface [nucleotide binding]; other site 446468008286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468008287 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468008288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468008289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468008290 WHG domain; Region: WHG; pfam13305 446468008291 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446468008292 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446468008293 Predicted dehydrogenase [General function prediction only]; Region: COG0579 446468008294 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468008295 Nitrate and nitrite sensing; Region: NIT; pfam08376 446468008296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468008297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468008298 ATP binding site [chemical binding]; other site 446468008299 Mg2+ binding site [ion binding]; other site 446468008300 G-X-G motif; other site 446468008301 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 446468008302 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468008303 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 446468008304 G1 box; other site 446468008305 GTP/Mg2+ binding site [chemical binding]; other site 446468008306 G2 box; other site 446468008307 Switch I region; other site 446468008308 G3 box; other site 446468008309 Switch II region; other site 446468008310 G4 box; other site 446468008311 G5 box; other site 446468008312 Protein of unknown function (DUF742); Region: DUF742; pfam05331 446468008313 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 446468008314 Nitrate and nitrite sensing; Region: NIT; pfam08376 446468008315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468008316 ATP binding site [chemical binding]; other site 446468008317 Mg2+ binding site [ion binding]; other site 446468008318 G-X-G motif; other site 446468008319 argininosuccinate lyase; Provisional; Region: PRK00855 446468008320 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 446468008321 active sites [active] 446468008322 tetramer interface [polypeptide binding]; other site 446468008323 arginine repressor; Provisional; Region: PRK03341 446468008324 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 446468008325 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 446468008326 ornithine carbamoyltransferase; Provisional; Region: PRK00779 446468008327 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446468008328 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446468008329 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 446468008330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468008331 inhibitor-cofactor binding pocket; inhibition site 446468008332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468008333 catalytic residue [active] 446468008334 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 446468008335 homohexameric interface [polypeptide binding]; other site 446468008336 feedback inhibition sensing region; other site 446468008337 carbamate kinase; Reviewed; Region: PRK12686 446468008338 nucleotide binding site [chemical binding]; other site 446468008339 N-acetyl-L-glutamate binding site [chemical binding]; other site 446468008340 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 446468008341 active site pocket [active] 446468008342 cleavage site 446468008343 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 446468008344 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446468008345 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 446468008346 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 446468008347 MarR family; Region: MarR; pfam01047 446468008348 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468008349 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 446468008350 inhibitor-cofactor binding pocket; inhibition site 446468008351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468008352 catalytic residue [active] 446468008353 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 446468008354 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 446468008355 putative tRNA-binding site [nucleotide binding]; other site 446468008356 B3/4 domain; Region: B3_4; pfam03483 446468008357 tRNA synthetase B5 domain; Region: B5; smart00874 446468008358 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 446468008359 dimer interface [polypeptide binding]; other site 446468008360 motif 1; other site 446468008361 motif 3; other site 446468008362 motif 2; other site 446468008363 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 446468008364 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 446468008365 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 446468008366 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 446468008367 dimer interface [polypeptide binding]; other site 446468008368 motif 1; other site 446468008369 active site 446468008370 motif 2; other site 446468008371 motif 3; other site 446468008372 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446468008373 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 446468008374 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446468008375 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 446468008376 23S rRNA binding site [nucleotide binding]; other site 446468008377 L21 binding site [polypeptide binding]; other site 446468008378 L13 binding site [polypeptide binding]; other site 446468008379 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 446468008380 translation initiation factor IF-3; Region: infC; TIGR00168 446468008381 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 446468008382 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 446468008383 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 446468008384 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 446468008385 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 446468008386 YceG-like family; Region: YceG; pfam02618 446468008387 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 446468008388 dimerization interface [polypeptide binding]; other site 446468008389 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 446468008390 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 446468008391 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 446468008392 motif 1; other site 446468008393 active site 446468008394 motif 2; other site 446468008395 motif 3; other site 446468008396 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 446468008397 Protein of unknown function DUF262; Region: DUF262; pfam03235 446468008398 Uncharacterized conserved protein [Function unknown]; Region: COG1479 446468008399 Protein of unknown function DUF262; Region: DUF262; pfam03235 446468008400 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446468008401 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 446468008402 HsdM N-terminal domain; Region: HsdM_N; pfam12161 446468008403 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 446468008404 Methyltransferase domain; Region: Methyltransf_26; pfam13659 446468008405 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 446468008406 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 446468008407 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 446468008408 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 446468008409 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468008410 ATP binding site [chemical binding]; other site 446468008411 putative Mg++ binding site [ion binding]; other site 446468008412 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 446468008413 AAA domain; Region: AAA_23; pfam13476 446468008414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008416 Walker A/P-loop; other site 446468008417 Walker A/P-loop; other site 446468008418 ATP binding site [chemical binding]; other site 446468008419 ATP binding site [chemical binding]; other site 446468008420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008421 ABC transporter signature motif; other site 446468008422 Walker B; other site 446468008423 D-loop; other site 446468008424 H-loop/switch region; other site 446468008425 Protein kinase domain; Region: Pkinase; pfam00069 446468008426 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468008427 active site 446468008428 ATP binding site [chemical binding]; other site 446468008429 substrate binding site [chemical binding]; other site 446468008430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468008431 active site 446468008432 ATP binding site [chemical binding]; other site 446468008433 substrate binding site [chemical binding]; other site 446468008434 activation loop (A-loop); other site 446468008435 recombination factor protein RarA; Reviewed; Region: PRK13342 446468008436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468008437 Walker A motif; other site 446468008438 ATP binding site [chemical binding]; other site 446468008439 Walker B motif; other site 446468008440 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 446468008441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468008442 PAS domain; Region: PAS_9; pfam13426 446468008443 putative active site [active] 446468008444 heme pocket [chemical binding]; other site 446468008445 PAS fold; Region: PAS_3; pfam08447 446468008446 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468008447 GAF domain; Region: GAF; pfam01590 446468008448 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468008449 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 446468008450 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 446468008451 dimer interface [polypeptide binding]; other site 446468008452 anticodon binding site; other site 446468008453 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 446468008454 homodimer interface [polypeptide binding]; other site 446468008455 motif 1; other site 446468008456 active site 446468008457 motif 2; other site 446468008458 GAD domain; Region: GAD; pfam02938 446468008459 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446468008460 active site 446468008461 motif 3; other site 446468008462 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446468008463 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446468008464 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446468008465 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 446468008466 S-adenosylmethionine synthetase; Validated; Region: PRK05250 446468008467 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 446468008468 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 446468008469 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 446468008470 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 446468008471 Flavoprotein; Region: Flavoprotein; pfam02441 446468008472 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 446468008473 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 446468008474 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 446468008475 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 446468008476 catalytic site [active] 446468008477 G-X2-G-X-G-K; other site 446468008478 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 446468008479 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 446468008480 active site 446468008481 dimer interface [polypeptide binding]; other site 446468008482 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 446468008483 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 446468008484 heterodimer interface [polypeptide binding]; other site 446468008485 active site 446468008486 FMN binding site [chemical binding]; other site 446468008487 homodimer interface [polypeptide binding]; other site 446468008488 substrate binding site [chemical binding]; other site 446468008489 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 446468008490 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 446468008491 FAD binding pocket [chemical binding]; other site 446468008492 FAD binding motif [chemical binding]; other site 446468008493 phosphate binding motif [ion binding]; other site 446468008494 beta-alpha-beta structure motif; other site 446468008495 NAD binding pocket [chemical binding]; other site 446468008496 Iron coordination center [ion binding]; other site 446468008497 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 446468008498 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468008499 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468008500 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 446468008501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468008502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468008503 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 446468008504 IMP binding site; other site 446468008505 dimer interface [polypeptide binding]; other site 446468008506 interdomain contacts; other site 446468008507 partial ornithine binding site; other site 446468008508 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 446468008509 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 446468008510 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 446468008511 catalytic site [active] 446468008512 subunit interface [polypeptide binding]; other site 446468008513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468008514 dihydroorotase; Validated; Region: pyrC; PRK09357 446468008515 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 446468008516 active site 446468008517 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 446468008518 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 446468008519 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 446468008520 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 446468008521 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468008522 active site 446468008523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468008524 non-specific DNA binding site [nucleotide binding]; other site 446468008525 salt bridge; other site 446468008526 sequence-specific DNA binding site [nucleotide binding]; other site 446468008527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468008528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468008529 Coenzyme A binding pocket [chemical binding]; other site 446468008530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 446468008531 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 446468008532 FAD binding site [chemical binding]; other site 446468008533 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446468008534 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446468008535 substrate binding pocket [chemical binding]; other site 446468008536 chain length determination region; other site 446468008537 substrate-Mg2+ binding site; other site 446468008538 catalytic residues [active] 446468008539 aspartate-rich region 1; other site 446468008540 active site lid residues [active] 446468008541 aspartate-rich region 2; other site 446468008542 Predicted membrane protein [Function unknown]; Region: COG2311 446468008543 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468008544 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 446468008545 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468008546 NADP binding site [chemical binding]; other site 446468008547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446468008548 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468008549 NAD(P) binding site [chemical binding]; other site 446468008550 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 446468008551 thiamine phosphate binding site [chemical binding]; other site 446468008552 active site 446468008553 pyrophosphate binding site [ion binding]; other site 446468008554 Helix-turn-helix domain; Region: HTH_17; cl17695 446468008555 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 446468008556 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 446468008557 thiS-thiF/thiG interaction site; other site 446468008558 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 446468008559 ThiS interaction site; other site 446468008560 putative active site [active] 446468008561 tetramer interface [polypeptide binding]; other site 446468008562 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468008563 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468008564 active site 446468008565 ATP binding site [chemical binding]; other site 446468008566 substrate binding site [chemical binding]; other site 446468008567 activation loop (A-loop); other site 446468008568 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468008569 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468008570 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468008571 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468008572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468008573 active site 446468008574 phosphorylation site [posttranslational modification] 446468008575 intermolecular recognition site; other site 446468008576 dimerization interface [polypeptide binding]; other site 446468008577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468008578 DNA binding residues [nucleotide binding] 446468008579 dimerization interface [polypeptide binding]; other site 446468008580 phosphofructokinase; Region: PFK_mixed; TIGR02483 446468008581 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 446468008582 active site 446468008583 ADP/pyrophosphate binding site [chemical binding]; other site 446468008584 dimerization interface [polypeptide binding]; other site 446468008585 allosteric effector site; other site 446468008586 fructose-1,6-bisphosphate binding site; other site 446468008587 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 446468008588 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 446468008589 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 446468008590 Ligand Binding Site [chemical binding]; other site 446468008591 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 446468008592 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 446468008593 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446468008594 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 446468008595 Moco binding site; other site 446468008596 metal coordination site [ion binding]; other site 446468008597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468008598 ATP binding site [chemical binding]; other site 446468008599 Mg2+ binding site [ion binding]; other site 446468008600 G-X-G motif; other site 446468008601 Esterase/lipase [General function prediction only]; Region: COG1647 446468008602 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 446468008603 catalytic site [active] 446468008604 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 446468008605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 446468008606 putative acyl-acceptor binding pocket; other site 446468008607 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446468008608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468008609 nucleotide binding site [chemical binding]; other site 446468008610 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446468008611 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446468008612 acyl-activating enzyme (AAE) consensus motif; other site 446468008613 putative AMP binding site [chemical binding]; other site 446468008614 putative active site [active] 446468008615 putative CoA binding site [chemical binding]; other site 446468008616 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 446468008617 heme bH binding site [chemical binding]; other site 446468008618 intrachain domain interface; other site 446468008619 heme bL binding site [chemical binding]; other site 446468008620 interchain domain interface [polypeptide binding]; other site 446468008621 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 446468008622 Qo binding site; other site 446468008623 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 446468008624 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446468008625 iron-sulfur cluster [ion binding]; other site 446468008626 [2Fe-2S] cluster binding site [ion binding]; other site 446468008627 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446468008628 Cytochrome c; Region: Cytochrom_C; pfam00034 446468008629 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 446468008630 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 446468008631 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 446468008632 Subunit I/III interface [polypeptide binding]; other site 446468008633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446468008634 active site 446468008635 phosphorylation site [posttranslational modification] 446468008636 intermolecular recognition site; other site 446468008637 dimerization interface [polypeptide binding]; other site 446468008638 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 446468008639 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446468008640 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446468008641 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 446468008642 active site 446468008643 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468008644 AsnC family; Region: AsnC_trans_reg; pfam01037 446468008645 Rhomboid family; Region: Rhomboid; pfam01694 446468008646 hypothetical protein; Validated; Region: PRK07883 446468008647 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446468008648 active site 446468008649 catalytic site [active] 446468008650 substrate binding site [chemical binding]; other site 446468008651 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 446468008652 GIY-YIG motif/motif A; other site 446468008653 active site 446468008654 catalytic site [active] 446468008655 putative DNA binding site [nucleotide binding]; other site 446468008656 metal binding site [ion binding]; metal-binding site 446468008657 YacP-like NYN domain; Region: NYN_YacP; cl01491 446468008658 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 446468008659 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468008660 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468008661 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468008662 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468008663 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446468008664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468008665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446468008666 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446468008667 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446468008668 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 446468008669 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 446468008670 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 446468008671 D-pathway; other site 446468008672 Low-spin heme binding site [chemical binding]; other site 446468008673 Putative water exit pathway; other site 446468008674 Binuclear center (active site) [active] 446468008675 K-pathway; other site 446468008676 Putative proton exit pathway; other site 446468008677 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 446468008678 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 446468008679 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 446468008680 CPxP motif; other site 446468008681 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 446468008682 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 446468008683 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446468008684 RNA binding surface [nucleotide binding]; other site 446468008685 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468008686 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 446468008687 substrate binding site [chemical binding]; other site 446468008688 ATP binding site [chemical binding]; other site 446468008689 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 446468008690 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446468008691 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446468008692 Walker A/P-loop; other site 446468008693 ATP binding site [chemical binding]; other site 446468008694 Q-loop/lid; other site 446468008695 ABC transporter signature motif; other site 446468008696 Walker B; other site 446468008697 D-loop; other site 446468008698 H-loop/switch region; other site 446468008699 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446468008700 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446468008701 TM-ABC transporter signature motif; other site 446468008702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468008703 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446468008704 TM-ABC transporter signature motif; other site 446468008705 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 446468008706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468008707 active site 446468008708 phosphorylation site [posttranslational modification] 446468008709 intermolecular recognition site; other site 446468008710 dimerization interface [polypeptide binding]; other site 446468008711 ANTAR domain; Region: ANTAR; pfam03861 446468008712 Helix-turn-helix; Region: HTH_3; pfam01381 446468008713 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 446468008714 pyruvate kinase; Provisional; Region: PRK06247 446468008715 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 446468008716 domain interfaces; other site 446468008717 active site 446468008718 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 446468008719 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 446468008720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468008721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468008722 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 446468008723 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 446468008724 active site 446468008725 dimer interface [polypeptide binding]; other site 446468008726 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 446468008727 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 446468008728 active site 446468008729 FMN binding site [chemical binding]; other site 446468008730 substrate binding site [chemical binding]; other site 446468008731 3Fe-4S cluster binding site [ion binding]; other site 446468008732 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 446468008733 domain interface; other site 446468008734 Protein of unknown function DUF43; Region: DUF43; pfam01861 446468008735 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 446468008736 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 446468008737 catalytic residues [active] 446468008738 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 446468008739 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 446468008740 substrate binding site [chemical binding]; other site 446468008741 active site 446468008742 catalytic residues [active] 446468008743 heterodimer interface [polypeptide binding]; other site 446468008744 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 446468008745 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 446468008746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468008747 catalytic residue [active] 446468008748 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 446468008749 active site 446468008750 ribulose/triose binding site [chemical binding]; other site 446468008751 phosphate binding site [ion binding]; other site 446468008752 substrate (anthranilate) binding pocket [chemical binding]; other site 446468008753 product (indole) binding pocket [chemical binding]; other site 446468008754 Interferon-induced transmembrane protein; Region: CD225; pfam04505 446468008755 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 446468008756 Interferon-induced transmembrane protein; Region: CD225; pfam04505 446468008757 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 446468008758 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468008759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468008760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008761 Walker A/P-loop; other site 446468008762 ATP binding site [chemical binding]; other site 446468008763 Q-loop/lid; other site 446468008764 ABC transporter signature motif; other site 446468008765 Walker B; other site 446468008766 D-loop; other site 446468008767 H-loop/switch region; other site 446468008768 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468008769 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468008770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468008771 Walker A/P-loop; other site 446468008772 ATP binding site [chemical binding]; other site 446468008773 Q-loop/lid; other site 446468008774 ABC transporter signature motif; other site 446468008775 Walker B; other site 446468008776 D-loop; other site 446468008777 H-loop/switch region; other site 446468008778 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 446468008779 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446468008780 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 446468008781 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446468008782 substrate binding site [chemical binding]; other site 446468008783 glutamase interaction surface [polypeptide binding]; other site 446468008784 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 446468008785 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 446468008786 catalytic residues [active] 446468008787 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 446468008788 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 446468008789 putative active site [active] 446468008790 oxyanion strand; other site 446468008791 catalytic triad [active] 446468008792 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 446468008793 putative active site pocket [active] 446468008794 4-fold oligomerization interface [polypeptide binding]; other site 446468008795 metal binding residues [ion binding]; metal-binding site 446468008796 3-fold/trimer interface [polypeptide binding]; other site 446468008797 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 446468008798 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468008799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468008800 homodimer interface [polypeptide binding]; other site 446468008801 catalytic residue [active] 446468008802 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 446468008803 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 446468008804 NAD binding site [chemical binding]; other site 446468008805 dimerization interface [polypeptide binding]; other site 446468008806 product binding site; other site 446468008807 substrate binding site [chemical binding]; other site 446468008808 zinc binding site [ion binding]; other site 446468008809 catalytic residues [active] 446468008810 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 446468008811 Ferritin-like domain; Region: Ferritin; pfam00210 446468008812 ferroxidase diiron center [ion binding]; other site 446468008813 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 446468008814 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 446468008815 putative deacylase active site [active] 446468008816 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 446468008817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468008818 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 446468008819 acyl-activating enzyme (AAE) consensus motif; other site 446468008820 putative AMP binding site [chemical binding]; other site 446468008821 putative active site [active] 446468008822 putative CoA binding site [chemical binding]; other site 446468008823 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446468008824 DinB superfamily; Region: DinB_2; pfam12867 446468008825 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468008826 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446468008827 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 446468008828 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 446468008829 active site 446468008830 PHP Thumb interface [polypeptide binding]; other site 446468008831 metal binding site [ion binding]; metal-binding site 446468008832 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 446468008833 generic binding surface II; other site 446468008834 generic binding surface I; other site 446468008835 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468008836 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468008837 active site 446468008838 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446468008839 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 446468008840 heme-binding site [chemical binding]; other site 446468008841 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 446468008842 FAD binding pocket [chemical binding]; other site 446468008843 FAD binding motif [chemical binding]; other site 446468008844 phosphate binding motif [ion binding]; other site 446468008845 beta-alpha-beta structure motif; other site 446468008846 NAD binding pocket [chemical binding]; other site 446468008847 Heme binding pocket [chemical binding]; other site 446468008848 Rrf2 family protein; Region: rrf2_super; TIGR00738 446468008849 Transcriptional regulator; Region: Rrf2; pfam02082 446468008850 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468008851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468008852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468008853 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 446468008854 oligomerization interface [polypeptide binding]; other site 446468008855 active site 446468008856 metal binding site [ion binding]; metal-binding site 446468008857 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468008858 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 446468008859 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 446468008860 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 446468008861 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446468008862 active site 446468008863 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 446468008864 SxDxEG motif; other site 446468008865 active site 446468008866 metal binding site [ion binding]; metal-binding site 446468008867 homopentamer interface [polypeptide binding]; other site 446468008868 hypothetical protein; Provisional; Region: PRK07906 446468008869 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446468008870 putative metal binding site [ion binding]; other site 446468008871 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 446468008872 dimer interface [polypeptide binding]; other site 446468008873 catalytic triad [active] 446468008874 Cupin; Region: Cupin_6; pfam12852 446468008875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468008876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468008877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468008878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468008879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468008880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468008881 Predicted transcriptional regulators [Transcription]; Region: COG1733 446468008882 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 446468008883 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 446468008884 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468008885 putative NAD(P) binding site [chemical binding]; other site 446468008886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468008887 sequence-specific DNA binding site [nucleotide binding]; other site 446468008888 salt bridge; other site 446468008889 acyl-coenzyme A oxidase; Region: PLN02636 446468008890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468008891 active site 446468008892 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468008893 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446468008894 active site 446468008895 metal binding site [ion binding]; metal-binding site 446468008896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468008897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468008898 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 446468008899 beta-galactosidase; Region: BGL; TIGR03356 446468008900 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468008901 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446468008902 active site 446468008903 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446468008904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468008905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468008906 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 446468008907 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446468008908 carboxyltransferase (CT) interaction site; other site 446468008909 biotinylation site [posttranslational modification]; other site 446468008910 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 446468008911 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446468008912 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 446468008913 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 446468008914 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 446468008915 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 446468008916 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 446468008917 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 446468008918 active site 446468008919 catalytic motif [active] 446468008920 Zn binding site [ion binding]; other site 446468008921 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468008922 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446468008923 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446468008924 TM-ABC transporter signature motif; other site 446468008925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468008926 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 446468008927 TM-ABC transporter signature motif; other site 446468008928 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 446468008929 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468008930 Walker A/P-loop; other site 446468008931 ATP binding site [chemical binding]; other site 446468008932 Q-loop/lid; other site 446468008933 ABC transporter signature motif; other site 446468008934 Walker B; other site 446468008935 D-loop; other site 446468008936 H-loop/switch region; other site 446468008937 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446468008938 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 446468008939 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 446468008940 ligand binding site [chemical binding]; other site 446468008941 Lipase (class 2); Region: Lipase_2; pfam01674 446468008942 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468008943 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468008944 E3 interaction surface; other site 446468008945 lipoyl attachment site [posttranslational modification]; other site 446468008946 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446468008947 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446468008948 alpha subunit interface [polypeptide binding]; other site 446468008949 TPP binding site [chemical binding]; other site 446468008950 heterodimer interface [polypeptide binding]; other site 446468008951 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468008952 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 446468008953 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446468008954 tetramer interface [polypeptide binding]; other site 446468008955 TPP-binding site [chemical binding]; other site 446468008956 heterodimer interface [polypeptide binding]; other site 446468008957 phosphorylation loop region [posttranslational modification] 446468008958 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468008959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468008960 putative DNA binding site [nucleotide binding]; other site 446468008961 putative Zn2+ binding site [ion binding]; other site 446468008962 AsnC family; Region: AsnC_trans_reg; pfam01037 446468008963 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 446468008964 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 446468008965 active site 446468008966 substrate binding site [chemical binding]; other site 446468008967 metal binding site [ion binding]; metal-binding site 446468008968 purine nucleoside phosphorylase; Provisional; Region: PRK08202 446468008969 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446468008970 NAD(P) binding site [chemical binding]; other site 446468008971 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 446468008972 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468008973 NAD(P) binding site [chemical binding]; other site 446468008974 catalytic residues [active] 446468008975 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 446468008976 intersubunit interface [polypeptide binding]; other site 446468008977 active site 446468008978 catalytic residue [active] 446468008979 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468008980 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 446468008981 Protein of unknown function (DUF418); Region: DUF418; cl12135 446468008982 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 446468008983 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 446468008984 acyl-activating enzyme (AAE) consensus motif; other site 446468008985 putative AMP binding site [chemical binding]; other site 446468008986 putative active site [active] 446468008987 putative CoA binding site [chemical binding]; other site 446468008988 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446468008989 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 446468008990 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 446468008991 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 446468008992 putative homodimer interface [polypeptide binding]; other site 446468008993 putative homotetramer interface [polypeptide binding]; other site 446468008994 putative allosteric switch controlling residues; other site 446468008995 putative metal binding site [ion binding]; other site 446468008996 putative homodimer-homodimer interface [polypeptide binding]; other site 446468008997 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 446468008998 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 446468008999 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 446468009000 FAD binding pocket [chemical binding]; other site 446468009001 FAD binding motif [chemical binding]; other site 446468009002 phosphate binding motif [ion binding]; other site 446468009003 beta-alpha-beta structure motif; other site 446468009004 NAD binding pocket [chemical binding]; other site 446468009005 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446468009006 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 446468009007 Moco binding site; other site 446468009008 metal coordination site [ion binding]; other site 446468009009 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468009010 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009011 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446468009012 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446468009013 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446468009014 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 446468009015 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468009016 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468009017 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 446468009018 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446468009019 carboxyltransferase (CT) interaction site; other site 446468009020 biotinylation site [posttranslational modification]; other site 446468009021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468009022 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468009023 active site 446468009024 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 446468009025 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 446468009026 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 446468009027 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 446468009028 active site 446468009029 dimer interface [polypeptide binding]; other site 446468009030 motif 1; other site 446468009031 motif 2; other site 446468009032 motif 3; other site 446468009033 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 446468009034 anticodon binding site; other site 446468009035 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 446468009036 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 446468009037 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446468009038 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 446468009039 homodimer interface [polypeptide binding]; other site 446468009040 substrate-cofactor binding pocket; other site 446468009041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468009042 catalytic residue [active] 446468009043 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 446468009044 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468009045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468009046 DNA-binding site [nucleotide binding]; DNA binding site 446468009047 FCD domain; Region: FCD; pfam07729 446468009048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468009049 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468009050 putative substrate translocation pore; other site 446468009051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468009052 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446468009053 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 446468009054 putative NAD(P) binding site [chemical binding]; other site 446468009055 catalytic Zn binding site [ion binding]; other site 446468009056 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 446468009057 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 446468009058 putative active site pocket [active] 446468009059 putative metal binding site [ion binding]; other site 446468009060 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468009061 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446468009062 ATP binding site [chemical binding]; other site 446468009063 substrate binding site [chemical binding]; other site 446468009064 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 446468009065 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 446468009066 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 446468009067 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446468009068 active site 446468009069 intersubunit interface [polypeptide binding]; other site 446468009070 catalytic residue [active] 446468009071 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468009072 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446468009073 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 446468009074 DNA binding residues [nucleotide binding] 446468009075 dimer interface [polypeptide binding]; other site 446468009076 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 446468009077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 446468009078 active site 446468009079 metal binding site [ion binding]; metal-binding site 446468009080 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 446468009081 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468009082 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 446468009083 substrate binding site [chemical binding]; other site 446468009084 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 446468009085 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 446468009086 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 446468009087 active site 446468009088 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468009089 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 446468009090 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446468009091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468009092 CHAT domain; Region: CHAT; pfam12770 446468009093 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 446468009094 enoyl-CoA hydratase; Provisional; Region: PRK07827 446468009095 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468009096 substrate binding site [chemical binding]; other site 446468009097 oxyanion hole (OAH) forming residues; other site 446468009098 trimer interface [polypeptide binding]; other site 446468009099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468009100 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468009101 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446468009102 CoA binding domain; Region: CoA_binding_2; pfam13380 446468009103 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446468009104 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446468009105 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468009106 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446468009107 substrate binding site [chemical binding]; other site 446468009108 ATP binding site [chemical binding]; other site 446468009109 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 446468009110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468009111 ATP binding site [chemical binding]; other site 446468009112 putative Mg++ binding site [ion binding]; other site 446468009113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468009114 nucleotide binding region [chemical binding]; other site 446468009115 ATP-binding site [chemical binding]; other site 446468009116 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 446468009117 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 446468009118 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 446468009119 CAP-like domain; other site 446468009120 active site 446468009121 primary dimer interface [polypeptide binding]; other site 446468009122 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 446468009123 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 446468009124 active site clefts [active] 446468009125 zinc binding site [ion binding]; other site 446468009126 dimer interface [polypeptide binding]; other site 446468009127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468009128 binding surface 446468009129 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446468009130 TPR motif; other site 446468009131 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446468009132 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 446468009133 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446468009134 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468009135 catalytic residue [active] 446468009136 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 446468009137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468009138 ATP binding site [chemical binding]; other site 446468009139 Mg2+ binding site [ion binding]; other site 446468009140 G-X-G motif; other site 446468009141 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 446468009142 anchoring element; other site 446468009143 dimer interface [polypeptide binding]; other site 446468009144 ATP binding site [chemical binding]; other site 446468009145 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 446468009146 active site 446468009147 metal binding site [ion binding]; metal-binding site 446468009148 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 446468009149 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468009150 hypothetical protein; Validated; Region: PRK02101 446468009151 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 446468009152 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 446468009153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468009154 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468009155 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468009156 DNA binding residues [nucleotide binding] 446468009157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468009158 putative active site [active] 446468009159 PAS fold; Region: PAS_3; pfam08447 446468009160 heme pocket [chemical binding]; other site 446468009161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468009162 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446468009163 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446468009164 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468009165 large tegument protein UL36; Provisional; Region: PHA03247 446468009166 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 446468009167 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 446468009168 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 446468009169 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 446468009170 active site 446468009171 Substrate binding site; other site 446468009172 Mg++ binding site; other site 446468009173 stage V sporulation protein K; Region: spore_V_K; TIGR02881 446468009174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468009175 Walker A motif; other site 446468009176 ATP binding site [chemical binding]; other site 446468009177 Walker B motif; other site 446468009178 arginine finger; other site 446468009179 stage V sporulation protein K; Region: spore_V_K; TIGR02881 446468009180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468009181 Walker A motif; other site 446468009182 ATP binding site [chemical binding]; other site 446468009183 Walker B motif; other site 446468009184 arginine finger; other site 446468009185 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 446468009186 RNA/DNA hybrid binding site [nucleotide binding]; other site 446468009187 active site 446468009188 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446468009189 SPFH domain / Band 7 family; Region: Band_7; pfam01145 446468009190 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 446468009191 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446468009192 SPFH domain / Band 7 family; Region: Band_7; pfam01145 446468009193 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 446468009194 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 446468009195 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 446468009196 protein-splicing catalytic site; other site 446468009197 thioester formation/cholesterol transfer; other site 446468009198 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 446468009199 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 446468009200 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 446468009201 protein-splicing catalytic site; other site 446468009202 thioester formation/cholesterol transfer; other site 446468009203 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 446468009204 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 446468009205 TSCPD domain; Region: TSCPD; pfam12637 446468009206 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 446468009207 ATP cone domain; Region: ATP-cone; pfam03477 446468009208 LexA repressor; Validated; Region: PRK00215 446468009209 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 446468009210 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 446468009211 Catalytic site [active] 446468009212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468009213 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 446468009214 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 446468009215 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 446468009216 HIGH motif; other site 446468009217 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 446468009218 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468009219 active site 446468009220 KMSKS motif; other site 446468009221 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 446468009222 tRNA binding surface [nucleotide binding]; other site 446468009223 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 446468009224 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 446468009225 acyl-activating enzyme (AAE) consensus motif; other site 446468009226 putative AMP binding site [chemical binding]; other site 446468009227 putative active site [active] 446468009228 putative CoA binding site [chemical binding]; other site 446468009229 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468009230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009231 dimer interface [polypeptide binding]; other site 446468009232 conserved gate region; other site 446468009233 putative PBP binding loops; other site 446468009234 ABC-ATPase subunit interface; other site 446468009235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009236 dimer interface [polypeptide binding]; other site 446468009237 conserved gate region; other site 446468009238 putative PBP binding loops; other site 446468009239 ABC-ATPase subunit interface; other site 446468009240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468009241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468009242 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 446468009243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009244 S-adenosylmethionine binding site [chemical binding]; other site 446468009245 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468009246 FAD binding domain; Region: FAD_binding_4; pfam01565 446468009247 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468009248 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446468009249 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 446468009250 DEAD/DEAH box helicase; Region: DEAD; pfam00270 446468009251 ATP binding site [chemical binding]; other site 446468009252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 446468009253 putative Mg++ binding site [ion binding]; other site 446468009254 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 446468009255 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 446468009256 putative hydrophobic ligand binding site [chemical binding]; other site 446468009257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468009258 putative DNA binding site [nucleotide binding]; other site 446468009259 putative Zn2+ binding site [ion binding]; other site 446468009260 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446468009261 oligomerisation interface [polypeptide binding]; other site 446468009262 mobile loop; other site 446468009263 roof hairpin; other site 446468009264 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468009265 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009266 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468009267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468009268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468009269 Walker A/P-loop; other site 446468009270 ATP binding site [chemical binding]; other site 446468009271 Q-loop/lid; other site 446468009272 ABC transporter signature motif; other site 446468009273 Walker B; other site 446468009274 D-loop; other site 446468009275 H-loop/switch region; other site 446468009276 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446468009277 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 446468009278 phosphate binding site [ion binding]; other site 446468009279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468009280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009281 dimer interface [polypeptide binding]; other site 446468009282 conserved gate region; other site 446468009283 putative PBP binding loops; other site 446468009284 ABC-ATPase subunit interface; other site 446468009285 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468009286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009287 dimer interface [polypeptide binding]; other site 446468009288 conserved gate region; other site 446468009289 putative PBP binding loops; other site 446468009290 ABC-ATPase subunit interface; other site 446468009291 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468009292 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468009293 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 446468009294 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 446468009295 active site 446468009296 catalytic site [active] 446468009297 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 446468009298 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468009299 catalytic core [active] 446468009300 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 446468009301 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 446468009302 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 446468009303 active site 446468009304 (T/H)XGH motif; other site 446468009305 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 446468009306 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468009307 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 446468009308 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 446468009309 putative catalytic cysteine [active] 446468009310 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468009311 active site 446468009312 CoA binding site [chemical binding]; other site 446468009313 AMP binding site [chemical binding]; other site 446468009314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468009315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468009316 active site 446468009317 catalytic tetrad [active] 446468009318 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468009319 MarR family; Region: MarR_2; pfam12802 446468009320 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 446468009321 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 446468009322 dimer interface [polypeptide binding]; other site 446468009323 active site 446468009324 CoA binding pocket [chemical binding]; other site 446468009325 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446468009326 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446468009327 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 446468009328 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 446468009329 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468009330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 446468009331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468009332 hypothetical protein; Provisional; Region: PRK06184 446468009333 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468009334 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468009335 AMP-binding enzyme; Region: AMP-binding; pfam00501 446468009336 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 446468009337 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446468009338 gamma-glutamyl kinase; Provisional; Region: PRK05429 446468009339 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 446468009340 homotetrameric interface [polypeptide binding]; other site 446468009341 putative phosphate binding site [ion binding]; other site 446468009342 putative allosteric binding site; other site 446468009343 nucleotide binding site [chemical binding]; other site 446468009344 PUA domain; Region: PUA; pfam01472 446468009345 GTPase CgtA; Reviewed; Region: obgE; PRK12296 446468009346 GTP1/OBG; Region: GTP1_OBG; pfam01018 446468009347 Obg GTPase; Region: Obg; cd01898 446468009348 G1 box; other site 446468009349 GTP/Mg2+ binding site [chemical binding]; other site 446468009350 Switch I region; other site 446468009351 G2 box; other site 446468009352 G3 box; other site 446468009353 Switch II region; other site 446468009354 G4 box; other site 446468009355 G5 box; other site 446468009356 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 446468009357 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 446468009358 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 446468009359 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 446468009360 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 446468009361 homodimer interface [polypeptide binding]; other site 446468009362 oligonucleotide binding site [chemical binding]; other site 446468009363 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 446468009364 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 446468009365 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 446468009366 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 446468009367 B12 binding site [chemical binding]; other site 446468009368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468009369 FeS/SAM binding site; other site 446468009370 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 446468009371 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 446468009372 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446468009373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446468009374 rod shape-determining protein MreC; Provisional; Region: PRK13922 446468009375 rod shape-determining protein MreC; Region: MreC; pfam04085 446468009376 rod shape-determining protein MreB; Provisional; Region: PRK13927 446468009377 MreB and similar proteins; Region: MreB_like; cd10225 446468009378 nucleotide binding site [chemical binding]; other site 446468009379 Mg binding site [ion binding]; other site 446468009380 putative protofilament interaction site [polypeptide binding]; other site 446468009381 RodZ interaction site [polypeptide binding]; other site 446468009382 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 446468009383 active site 446468009384 multimer interface [polypeptide binding]; other site 446468009385 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 446468009386 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446468009387 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468009388 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 446468009389 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 446468009390 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 446468009391 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 446468009392 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446468009393 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 446468009394 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 446468009395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468009396 Walker A motif; other site 446468009397 ATP binding site [chemical binding]; other site 446468009398 Walker B motif; other site 446468009399 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 446468009400 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446468009401 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446468009402 oligomer interface [polypeptide binding]; other site 446468009403 active site residues [active] 446468009404 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446468009405 Clp protease; Region: CLP_protease; pfam00574 446468009406 oligomer interface [polypeptide binding]; other site 446468009407 active site residues [active] 446468009408 trigger factor; Provisional; Region: tig; PRK01490 446468009409 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 446468009410 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 446468009411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 446468009412 active site 446468009413 HIGH motif; other site 446468009414 nucleotide binding site [chemical binding]; other site 446468009415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468009416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468009417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468009418 Walker A/P-loop; other site 446468009419 ATP binding site [chemical binding]; other site 446468009420 Q-loop/lid; other site 446468009421 ABC transporter signature motif; other site 446468009422 Walker B; other site 446468009423 D-loop; other site 446468009424 H-loop/switch region; other site 446468009425 Peptidase family M23; Region: Peptidase_M23; pfam01551 446468009426 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 446468009427 MgtE intracellular N domain; Region: MgtE_N; pfam03448 446468009428 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 446468009429 Divalent cation transporter; Region: MgtE; pfam01769 446468009430 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468009431 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 446468009432 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 446468009433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468009434 NAD binding site [chemical binding]; other site 446468009435 catalytic residues [active] 446468009436 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 446468009437 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446468009438 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 446468009439 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 446468009440 Zn binding site [ion binding]; other site 446468009441 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 446468009442 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 446468009443 Amidase; Region: Amidase; cl11426 446468009444 Nuclease-related domain; Region: NERD; pfam08378 446468009445 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 446468009446 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 446468009447 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 446468009448 oligomeric interface; other site 446468009449 putative active site [active] 446468009450 homodimer interface [polypeptide binding]; other site 446468009451 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 446468009452 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446468009453 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468009454 active site 446468009455 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 446468009456 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468009457 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 446468009458 active site 446468009459 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 446468009460 apolar tunnel; other site 446468009461 heme binding site [chemical binding]; other site 446468009462 dimerization interface [polypeptide binding]; other site 446468009463 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 446468009464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468009465 Walker A/P-loop; other site 446468009466 ATP binding site [chemical binding]; other site 446468009467 Q-loop/lid; other site 446468009468 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468009469 ABC transporter; Region: ABC_tran_2; pfam12848 446468009470 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468009471 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 446468009472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 446468009473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 446468009474 metal binding site [ion binding]; metal-binding site 446468009475 active site 446468009476 I-site; other site 446468009477 YfjP GTPase; Region: YfjP; cd11383 446468009478 G1 box; other site 446468009479 GTP/Mg2+ binding site [chemical binding]; other site 446468009480 Switch I region; other site 446468009481 G2 box; other site 446468009482 Switch II region; other site 446468009483 G3 box; other site 446468009484 G4 box; other site 446468009485 G5 box; other site 446468009486 Protein of unknown function, DUF258; Region: DUF258; pfam03193 446468009487 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446468009488 Dynamin family; Region: Dynamin_N; pfam00350 446468009489 G1 box; other site 446468009490 GTP/Mg2+ binding site [chemical binding]; other site 446468009491 G2 box; other site 446468009492 Switch I region; other site 446468009493 G3 box; other site 446468009494 Switch II region; other site 446468009495 G4 box; other site 446468009496 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 446468009497 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446468009498 active site 446468009499 SAM binding site [chemical binding]; other site 446468009500 homodimer interface [polypeptide binding]; other site 446468009501 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 446468009502 FMN binding site [chemical binding]; other site 446468009503 dimer interface [polypeptide binding]; other site 446468009504 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 446468009505 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 446468009506 putative dimer interface [polypeptide binding]; other site 446468009507 active site pocket [active] 446468009508 putative cataytic base [active] 446468009509 hypothetical protein; Provisional; Region: PRK07908 446468009510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468009511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468009512 homodimer interface [polypeptide binding]; other site 446468009513 catalytic residue [active] 446468009514 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446468009515 amidase catalytic site [active] 446468009516 Zn binding residues [ion binding]; other site 446468009517 substrate binding site [chemical binding]; other site 446468009518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468009519 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468009520 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468009521 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468009522 active site 446468009523 ATP binding site [chemical binding]; other site 446468009524 substrate binding site [chemical binding]; other site 446468009525 activation loop (A-loop); other site 446468009526 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 446468009527 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 446468009528 NADP binding site [chemical binding]; other site 446468009529 dimer interface [polypeptide binding]; other site 446468009530 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446468009531 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446468009532 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 446468009533 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446468009534 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446468009535 active site 446468009536 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 446468009537 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468009538 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446468009539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468009540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009541 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 446468009542 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 446468009543 Int/Topo IB signature motif; other site 446468009544 Phosphotransferase enzyme family; Region: APH; pfam01636 446468009545 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468009546 substrate binding site [chemical binding]; other site 446468009547 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 446468009548 active site 446468009549 GIY-YIG motif/motif A; other site 446468009550 catalytic site [active] 446468009551 metal binding site [ion binding]; metal-binding site 446468009552 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468009553 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468009554 PQQ-like domain; Region: PQQ_2; pfam13360 446468009555 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 446468009556 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 446468009557 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 446468009558 NAD binding site [chemical binding]; other site 446468009559 catalytic Zn binding site [ion binding]; other site 446468009560 structural Zn binding site [ion binding]; other site 446468009561 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 446468009562 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 446468009563 Int/Topo IB signature motif; other site 446468009564 Phosphotransferase enzyme family; Region: APH; pfam01636 446468009565 serine/threonine protein kinase; Provisional; Region: PRK11768 446468009566 putative methyltransferase; Provisional; Region: PRK14967 446468009567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009568 S-adenosylmethionine binding site [chemical binding]; other site 446468009569 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 446468009570 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 446468009571 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 446468009572 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 446468009573 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468009574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468009575 active site 446468009576 metal binding site [ion binding]; metal-binding site 446468009577 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468009578 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 446468009579 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468009580 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468009581 Walker A/P-loop; other site 446468009582 ATP binding site [chemical binding]; other site 446468009583 Q-loop/lid; other site 446468009584 ABC transporter signature motif; other site 446468009585 Walker B; other site 446468009586 D-loop; other site 446468009587 H-loop/switch region; other site 446468009588 FtsX-like permease family; Region: FtsX; pfam02687 446468009589 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446468009590 substrate binding pocket [chemical binding]; other site 446468009591 chain length determination region; other site 446468009592 substrate-Mg2+ binding site; other site 446468009593 catalytic residues [active] 446468009594 aspartate-rich region 1; other site 446468009595 active site lid residues [active] 446468009596 aspartate-rich region 2; other site 446468009597 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446468009598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468009599 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446468009600 substrate binding site [chemical binding]; other site 446468009601 ATP binding site [chemical binding]; other site 446468009602 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 446468009603 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 446468009604 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 446468009605 putative active site [active] 446468009606 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446468009607 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 446468009608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009609 dimer interface [polypeptide binding]; other site 446468009610 conserved gate region; other site 446468009611 putative PBP binding loops; other site 446468009612 ABC-ATPase subunit interface; other site 446468009613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468009614 dimer interface [polypeptide binding]; other site 446468009615 conserved gate region; other site 446468009616 putative PBP binding loops; other site 446468009617 ABC-ATPase subunit interface; other site 446468009618 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 446468009619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468009620 Walker A/P-loop; other site 446468009621 ATP binding site [chemical binding]; other site 446468009622 Q-loop/lid; other site 446468009623 ABC transporter signature motif; other site 446468009624 Walker B; other site 446468009625 D-loop; other site 446468009626 H-loop/switch region; other site 446468009627 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468009628 catalytic core [active] 446468009629 argininosuccinate synthase; Validated; Region: PRK05370 446468009630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009631 S-adenosylmethionine binding site [chemical binding]; other site 446468009632 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446468009633 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468009634 DNA binding residues [nucleotide binding] 446468009635 high affinity sulphate transporter 1; Region: sulP; TIGR00815 446468009636 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 446468009637 Sulfate transporter family; Region: Sulfate_transp; pfam00916 446468009638 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 446468009639 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 446468009640 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 446468009641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468009642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009643 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468009644 Cytochrome P450; Region: p450; cl12078 446468009645 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 446468009646 classical (c) SDRs; Region: SDR_c; cd05233 446468009647 NAD(P) binding site [chemical binding]; other site 446468009648 active site 446468009649 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009650 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468009651 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446468009652 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 446468009653 metal binding site [ion binding]; metal-binding site 446468009654 active site 446468009655 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446468009656 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 446468009657 NAD binding site [chemical binding]; other site 446468009658 substrate binding site [chemical binding]; other site 446468009659 catalytic Zn binding site [ion binding]; other site 446468009660 structural Zn binding site [ion binding]; other site 446468009661 Domain of unknown function DUF59; Region: DUF59; pfam01883 446468009662 Amidohydrolase; Region: Amidohydro_2; pfam04909 446468009663 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 446468009664 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468009665 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468009666 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468009667 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446468009668 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446468009669 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446468009670 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 446468009671 intermolecular salt bridges; other site 446468009672 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 446468009673 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446468009674 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 446468009675 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 446468009676 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 446468009677 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468009678 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468009679 Walker A/P-loop; other site 446468009680 ATP binding site [chemical binding]; other site 446468009681 Q-loop/lid; other site 446468009682 ABC transporter signature motif; other site 446468009683 Walker B; other site 446468009684 D-loop; other site 446468009685 H-loop/switch region; other site 446468009686 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 446468009687 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468009688 substrate binding site [chemical binding]; other site 446468009689 ATP binding site [chemical binding]; other site 446468009690 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468009691 classical (c) SDRs; Region: SDR_c; cd05233 446468009692 NAD(P) binding site [chemical binding]; other site 446468009693 active site 446468009694 HTH domain; Region: HTH_11; pfam08279 446468009695 WYL domain; Region: WYL; pfam13280 446468009696 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446468009697 active site 446468009698 catalytic triad [active] 446468009699 dimer interface [polypeptide binding]; other site 446468009700 Histidine kinase; Region: HisKA_3; pfam07730 446468009701 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468009702 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468009703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468009704 active site 446468009705 phosphorylation site [posttranslational modification] 446468009706 intermolecular recognition site; other site 446468009707 dimerization interface [polypeptide binding]; other site 446468009708 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468009709 DNA binding residues [nucleotide binding] 446468009710 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446468009711 Cellulose binding domain; Region: CBM_2; pfam00553 446468009712 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446468009713 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 446468009714 short chain dehydrogenase; Provisional; Region: PRK06914 446468009715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468009716 NAD(P) binding site [chemical binding]; other site 446468009717 active site 446468009718 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 446468009719 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468009720 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446468009721 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 446468009722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009723 S-adenosylmethionine binding site [chemical binding]; other site 446468009724 hypothetical protein; Provisional; Region: PRK08317 446468009725 Benzoate membrane transport protein; Region: BenE; pfam03594 446468009726 benzoate transporter; Region: benE; TIGR00843 446468009727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468009728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468009729 Coenzyme A binding pocket [chemical binding]; other site 446468009730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 446468009731 active site 446468009732 NTP binding site [chemical binding]; other site 446468009733 metal binding triad [ion binding]; metal-binding site 446468009734 Predicted membrane protein [Function unknown]; Region: COG2311 446468009735 Protein of unknown function (DUF418); Region: DUF418; cl12135 446468009736 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468009737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468009738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468009739 Phosphotransferase enzyme family; Region: APH; pfam01636 446468009740 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 446468009741 active site 446468009742 substrate binding site [chemical binding]; other site 446468009743 ATP binding site [chemical binding]; other site 446468009744 BCCT family transporter; Region: BCCT; pfam02028 446468009745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468009746 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468009747 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468009748 active site 446468009749 catalytic tetrad [active] 446468009750 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 446468009751 Prostaglandin dehydrogenases; Region: PGDH; cd05288 446468009752 NAD(P) binding site [chemical binding]; other site 446468009753 substrate binding site [chemical binding]; other site 446468009754 dimer interface [polypeptide binding]; other site 446468009755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468009756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468009757 LysR substrate binding domain; Region: LysR_substrate; pfam03466 446468009758 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 446468009759 putative metal binding site [ion binding]; other site 446468009760 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446468009761 putative catalytic site [active] 446468009762 putative phosphate binding site [ion binding]; other site 446468009763 putative metal binding site [ion binding]; other site 446468009764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468009765 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 446468009766 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 446468009767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468009768 active site 446468009769 motif I; other site 446468009770 motif II; other site 446468009771 putative acetyltransferase; Provisional; Region: PRK03624 446468009772 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468009773 Coenzyme A binding pocket [chemical binding]; other site 446468009774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009775 S-adenosylmethionine binding site [chemical binding]; other site 446468009776 Cupin; Region: Cupin_6; pfam12852 446468009777 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468009778 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468009779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468009780 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468009781 NAD(P) binding site [chemical binding]; other site 446468009782 active site 446468009783 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468009784 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 446468009785 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446468009786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468009787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468009788 putative substrate translocation pore; other site 446468009789 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 446468009790 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 446468009791 conserved cys residue [active] 446468009792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468009793 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 446468009794 metal ion-dependent adhesion site (MIDAS); other site 446468009795 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 446468009796 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 446468009797 Domain of unknown function (DUF892); Region: DUF892; pfam05974 446468009798 hypothetical protein; Provisional; Region: PRK05463 446468009799 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 446468009800 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 446468009801 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 446468009802 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 446468009803 putative active site [active] 446468009804 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 446468009805 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468009806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468009807 DNA-binding site [nucleotide binding]; DNA binding site 446468009808 FCD domain; Region: FCD; pfam07729 446468009809 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446468009810 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 446468009811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009812 S-adenosylmethionine binding site [chemical binding]; other site 446468009813 hypothetical protein; Provisional; Region: PRK09266 446468009814 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 446468009815 substrate-cofactor binding pocket; other site 446468009816 homodimer interface [polypeptide binding]; other site 446468009817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468009818 catalytic residue [active] 446468009819 MMPL family; Region: MMPL; pfam03176 446468009820 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 446468009821 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468009822 putative NAD(P) binding site [chemical binding]; other site 446468009823 putative active site [active] 446468009824 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 446468009825 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 446468009826 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468009827 DNA binding residues [nucleotide binding] 446468009828 B12 binding domain; Region: B12-binding_2; pfam02607 446468009829 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 446468009830 lycopene cyclase; Region: lycopene_cycl; TIGR01789 446468009831 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446468009832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009833 S-adenosylmethionine binding site [chemical binding]; other site 446468009834 Uncharacterized conserved protein [Function unknown]; Region: COG3349 446468009835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468009836 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 446468009837 iron-sulfur cluster [ion binding]; other site 446468009838 [2Fe-2S] cluster binding site [ion binding]; other site 446468009839 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 446468009840 active site lid residues [active] 446468009841 substrate binding pocket [chemical binding]; other site 446468009842 catalytic residues [active] 446468009843 substrate-Mg2+ binding site; other site 446468009844 aspartate-rich region 1; other site 446468009845 aspartate-rich region 2; other site 446468009846 phytoene desaturase; Region: crtI_fam; TIGR02734 446468009847 hydroxyglutarate oxidase; Provisional; Region: PRK11728 446468009848 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446468009849 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446468009850 substrate binding pocket [chemical binding]; other site 446468009851 chain length determination region; other site 446468009852 substrate-Mg2+ binding site; other site 446468009853 catalytic residues [active] 446468009854 aspartate-rich region 1; other site 446468009855 active site lid residues [active] 446468009856 aspartate-rich region 2; other site 446468009857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468009858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468009859 putative DNA binding site [nucleotide binding]; other site 446468009860 putative Zn2+ binding site [ion binding]; other site 446468009861 BCCT family transporter; Region: BCCT; pfam02028 446468009862 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446468009863 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446468009864 putative dimer interface [polypeptide binding]; other site 446468009865 Protein of unknown function (DUF461); Region: DUF461; pfam04314 446468009866 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 446468009867 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446468009868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468009869 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468009870 DNA binding residues [nucleotide binding] 446468009871 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 446468009872 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 446468009873 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 446468009874 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 446468009875 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 446468009876 oligomer interface [polypeptide binding]; other site 446468009877 RNA binding site [nucleotide binding]; other site 446468009878 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 446468009879 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 446468009880 RNase E interface [polypeptide binding]; other site 446468009881 trimer interface [polypeptide binding]; other site 446468009882 active site 446468009883 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 446468009884 putative nucleic acid binding region [nucleotide binding]; other site 446468009885 G-X-X-G motif; other site 446468009886 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 446468009887 RNA binding site [nucleotide binding]; other site 446468009888 domain interface; other site 446468009889 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 446468009890 16S/18S rRNA binding site [nucleotide binding]; other site 446468009891 S13e-L30e interaction site [polypeptide binding]; other site 446468009892 25S rRNA binding site [nucleotide binding]; other site 446468009893 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 446468009894 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 446468009895 active site 446468009896 Riboflavin kinase; Region: Flavokinase; pfam01687 446468009897 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 446468009898 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 446468009899 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468009900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 446468009901 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 446468009902 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 446468009903 RNA binding site [nucleotide binding]; other site 446468009904 active site 446468009905 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 446468009906 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 446468009907 Protein of unknown function (DUF503); Region: DUF503; pfam04456 446468009908 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446468009909 translation initiation factor IF-2; Region: IF-2; TIGR00487 446468009910 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 446468009911 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 446468009912 G1 box; other site 446468009913 putative GEF interaction site [polypeptide binding]; other site 446468009914 GTP/Mg2+ binding site [chemical binding]; other site 446468009915 Switch I region; other site 446468009916 G2 box; other site 446468009917 G3 box; other site 446468009918 Switch II region; other site 446468009919 G4 box; other site 446468009920 G5 box; other site 446468009921 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 446468009922 Translation-initiation factor 2; Region: IF-2; pfam11987 446468009923 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 446468009924 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 446468009925 NusA N-terminal domain; Region: NusA_N; pfam08529 446468009926 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 446468009927 RNA binding site [nucleotide binding]; other site 446468009928 homodimer interface [polypeptide binding]; other site 446468009929 NusA-like KH domain; Region: KH_5; pfam13184 446468009930 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 446468009931 G-X-X-G motif; other site 446468009932 Sm and related proteins; Region: Sm_like; cl00259 446468009933 ribosome maturation protein RimP; Reviewed; Region: PRK00092 446468009934 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 446468009935 putative oligomer interface [polypeptide binding]; other site 446468009936 putative RNA binding site [nucleotide binding]; other site 446468009937 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 446468009938 dinuclear metal binding motif [ion binding]; other site 446468009939 prolyl-tRNA synthetase; Provisional; Region: PRK09194 446468009940 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 446468009941 dimer interface [polypeptide binding]; other site 446468009942 motif 1; other site 446468009943 active site 446468009944 motif 2; other site 446468009945 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 446468009946 putative deacylase active site [active] 446468009947 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446468009948 active site 446468009949 motif 3; other site 446468009950 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 446468009951 anticodon binding site; other site 446468009952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468009953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468009954 Histidine kinase; Region: HisKA_3; pfam07730 446468009955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468009956 ATP binding site [chemical binding]; other site 446468009957 Mg2+ binding site [ion binding]; other site 446468009958 G-X-G motif; other site 446468009959 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468009960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468009961 active site 446468009962 phosphorylation site [posttranslational modification] 446468009963 intermolecular recognition site; other site 446468009964 dimerization interface [polypeptide binding]; other site 446468009965 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468009966 DNA binding residues [nucleotide binding] 446468009967 dimerization interface [polypeptide binding]; other site 446468009968 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 446468009969 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 446468009970 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 446468009971 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 446468009972 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 446468009973 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 446468009974 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 446468009975 G2 box; other site 446468009976 Switch I region; other site 446468009977 G3 box; other site 446468009978 Switch II region; other site 446468009979 G4 box; other site 446468009980 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 446468009981 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 446468009982 dimer interface [polypeptide binding]; other site 446468009983 motif 1; other site 446468009984 active site 446468009985 motif 2; other site 446468009986 motif 3; other site 446468009987 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 446468009988 anticodon binding site; other site 446468009989 AAA ATPase domain; Region: AAA_16; pfam13191 446468009990 Predicted ATPase [General function prediction only]; Region: COG3903 446468009991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468009992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468009993 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468009994 DNA binding residues [nucleotide binding] 446468009995 dimerization interface [polypeptide binding]; other site 446468009996 Predicted ATPase [General function prediction only]; Region: COG3903 446468009997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 446468009998 TPR motif; other site 446468009999 binding surface 446468010000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468010001 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468010002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468010003 DNA binding residues [nucleotide binding] 446468010004 dimerization interface [polypeptide binding]; other site 446468010005 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468010006 acyl-activating enzyme (AAE) consensus motif; other site 446468010007 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468010008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446468010009 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 446468010010 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468010011 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468010012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468010013 putative substrate translocation pore; other site 446468010014 Predicted acetyltransferase [General function prediction only]; Region: COG3393 446468010015 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 446468010016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468010017 Coenzyme A binding pocket [chemical binding]; other site 446468010018 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468010019 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468010020 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 446468010021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468010022 putative DNA binding site [nucleotide binding]; other site 446468010023 putative Zn2+ binding site [ion binding]; other site 446468010024 AsnC family; Region: AsnC_trans_reg; pfam01037 446468010025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468010026 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 446468010027 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446468010028 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 446468010029 putative active site [active] 446468010030 catalytic triad [active] 446468010031 putative dimer interface [polypeptide binding]; other site 446468010032 amino acid transporter; Region: 2A0306; TIGR00909 446468010033 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 446468010034 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 446468010035 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 446468010036 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 446468010037 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446468010038 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 446468010039 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 446468010040 active site 446468010041 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 446468010042 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 446468010043 putative substrate binding region [chemical binding]; other site 446468010044 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 446468010045 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 446468010046 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 446468010047 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 446468010048 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 446468010049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468010050 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 446468010051 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 446468010052 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468010053 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446468010054 NAD(P) binding site [chemical binding]; other site 446468010055 catalytic residues [active] 446468010056 thymidylate kinase; Region: DTMP_kinase; TIGR00041 446468010057 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446468010058 Protein of unknown function, DUF393; Region: DUF393; cl01136 446468010059 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 446468010060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468010061 Walker A/P-loop; other site 446468010062 ATP binding site [chemical binding]; other site 446468010063 Q-loop/lid; other site 446468010064 ABC transporter signature motif; other site 446468010065 Walker B; other site 446468010066 D-loop; other site 446468010067 H-loop/switch region; other site 446468010068 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446468010069 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468010070 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468010071 Walker A/P-loop; other site 446468010072 ATP binding site [chemical binding]; other site 446468010073 Q-loop/lid; other site 446468010074 ABC transporter signature motif; other site 446468010075 Walker B; other site 446468010076 D-loop; other site 446468010077 H-loop/switch region; other site 446468010078 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446468010079 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468010080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010081 putative PBP binding loops; other site 446468010082 dimer interface [polypeptide binding]; other site 446468010083 ABC-ATPase subunit interface; other site 446468010084 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468010085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010086 dimer interface [polypeptide binding]; other site 446468010087 conserved gate region; other site 446468010088 putative PBP binding loops; other site 446468010089 ABC-ATPase subunit interface; other site 446468010090 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 446468010091 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468010092 peptide binding site [polypeptide binding]; other site 446468010093 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 446468010094 AAA domain; Region: AAA_33; pfam13671 446468010095 ATP-binding site [chemical binding]; other site 446468010096 Gluconate-6-phosphate binding site [chemical binding]; other site 446468010097 Transcriptional regulators [Transcription]; Region: FadR; COG2186 446468010098 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 446468010099 DNA-binding site [nucleotide binding]; DNA binding site 446468010100 FCD domain; Region: FCD; pfam07729 446468010101 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 446468010102 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468010103 AAA ATPase domain; Region: AAA_16; pfam13191 446468010104 WD domain, G-beta repeat; Region: WD40; pfam00400 446468010105 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446468010106 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 446468010107 structural tetrad; other site 446468010108 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446468010109 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446468010110 structural tetrad; other site 446468010111 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 446468010112 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 446468010113 conserved cys residue [active] 446468010114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468010115 MarR family; Region: MarR_2; pfam12802 446468010116 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 446468010117 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468010118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468010119 catalytic residue [active] 446468010120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468010121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468010122 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468010123 glycerol kinase; Provisional; Region: glpK; PRK00047 446468010124 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 446468010125 N- and C-terminal domain interface [polypeptide binding]; other site 446468010126 active site 446468010127 MgATP binding site [chemical binding]; other site 446468010128 catalytic site [active] 446468010129 metal binding site [ion binding]; metal-binding site 446468010130 putative homotetramer interface [polypeptide binding]; other site 446468010131 glycerol binding site [chemical binding]; other site 446468010132 homodimer interface [polypeptide binding]; other site 446468010133 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 446468010134 amphipathic channel; other site 446468010135 Asn-Pro-Ala signature motifs; other site 446468010136 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 446468010137 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 446468010138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468010139 DNA-binding site [nucleotide binding]; DNA binding site 446468010140 RNA-binding motif; other site 446468010141 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 446468010142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468010143 Walker A/P-loop; other site 446468010144 ATP binding site [chemical binding]; other site 446468010145 Q-loop/lid; other site 446468010146 ABC transporter signature motif; other site 446468010147 Walker B; other site 446468010148 D-loop; other site 446468010149 H-loop/switch region; other site 446468010150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446468010151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468010152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468010153 Walker A/P-loop; other site 446468010154 ATP binding site [chemical binding]; other site 446468010155 Q-loop/lid; other site 446468010156 ABC transporter signature motif; other site 446468010157 Walker B; other site 446468010158 D-loop; other site 446468010159 H-loop/switch region; other site 446468010160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468010161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468010162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010163 dimer interface [polypeptide binding]; other site 446468010164 conserved gate region; other site 446468010165 putative PBP binding loops; other site 446468010166 ABC-ATPase subunit interface; other site 446468010167 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468010168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010169 dimer interface [polypeptide binding]; other site 446468010170 conserved gate region; other site 446468010171 putative PBP binding loops; other site 446468010172 ABC-ATPase subunit interface; other site 446468010173 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 446468010174 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 446468010175 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468010176 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468010177 DNA binding site [nucleotide binding] 446468010178 domain linker motif; other site 446468010179 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468010180 ligand binding site [chemical binding]; other site 446468010181 dimerization interface [polypeptide binding]; other site 446468010182 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 446468010183 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 446468010184 putative DNA binding site [nucleotide binding]; other site 446468010185 catalytic residue [active] 446468010186 putative H2TH interface [polypeptide binding]; other site 446468010187 putative catalytic residues [active] 446468010188 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 446468010189 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 446468010190 DNA helicase, putative; Region: TIGR00376 446468010191 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446468010192 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468010193 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 446468010194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468010195 inhibitor-cofactor binding pocket; inhibition site 446468010196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468010197 catalytic residue [active] 446468010198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468010199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468010200 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 446468010201 putative dimerization interface [polypeptide binding]; other site 446468010202 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 446468010203 Citrate transporter; Region: CitMHS; pfam03600 446468010204 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 446468010205 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 446468010206 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468010207 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468010208 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 446468010209 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468010210 inhibitor-cofactor binding pocket; inhibition site 446468010211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468010212 catalytic residue [active] 446468010213 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 446468010214 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 446468010215 tetrameric interface [polypeptide binding]; other site 446468010216 NAD binding site [chemical binding]; other site 446468010217 catalytic residues [active] 446468010218 Predicted amidohydrolase [General function prediction only]; Region: COG0388 446468010219 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 446468010220 putative active site [active] 446468010221 catalytic triad [active] 446468010222 putative dimer interface [polypeptide binding]; other site 446468010223 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468010224 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468010225 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468010226 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468010227 Walker A/P-loop; other site 446468010228 ATP binding site [chemical binding]; other site 446468010229 Q-loop/lid; other site 446468010230 ABC transporter signature motif; other site 446468010231 Walker B; other site 446468010232 D-loop; other site 446468010233 H-loop/switch region; other site 446468010234 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 446468010235 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 446468010236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468010237 FeS/SAM binding site; other site 446468010238 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 446468010239 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468010240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 446468010241 Penicillinase repressor; Region: Pencillinase_R; pfam03965 446468010242 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 446468010243 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446468010244 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 446468010245 TPP-binding site [chemical binding]; other site 446468010246 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 446468010247 PYR/PP interface [polypeptide binding]; other site 446468010248 dimer interface [polypeptide binding]; other site 446468010249 TPP binding site [chemical binding]; other site 446468010250 Uncharacterized conserved protein [Function unknown]; Region: COG3595 446468010251 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 446468010252 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468010253 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468010254 putative DNA binding site [nucleotide binding]; other site 446468010255 Malic enzyme, N-terminal domain; Region: malic; pfam00390 446468010256 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 446468010257 putative NAD(P) binding site [chemical binding]; other site 446468010258 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446468010259 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446468010260 substrate binding pocket [chemical binding]; other site 446468010261 membrane-bound complex binding site; other site 446468010262 hinge residues; other site 446468010263 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446468010264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446468010265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010266 ABC-ATPase subunit interface; other site 446468010267 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446468010268 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 446468010269 Walker A/P-loop; other site 446468010270 ATP binding site [chemical binding]; other site 446468010271 Q-loop/lid; other site 446468010272 ABC transporter signature motif; other site 446468010273 Walker B; other site 446468010274 D-loop; other site 446468010275 H-loop/switch region; other site 446468010276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468010277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468010278 S-adenosylmethionine binding site [chemical binding]; other site 446468010279 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468010280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468010281 Coenzyme A binding pocket [chemical binding]; other site 446468010282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446468010283 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 446468010284 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468010285 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 446468010286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468010287 DNA binding residues [nucleotide binding] 446468010288 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 446468010289 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 446468010290 Transcription factor WhiB; Region: Whib; pfam02467 446468010291 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 446468010292 PAS fold; Region: PAS_4; pfam08448 446468010293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 446468010294 Histidine kinase; Region: HisKA_2; pfam07568 446468010295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468010296 ATP binding site [chemical binding]; other site 446468010297 Mg2+ binding site [ion binding]; other site 446468010298 G-X-G motif; other site 446468010299 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468010300 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468010301 DNA-binding site [nucleotide binding]; DNA binding site 446468010302 UTRA domain; Region: UTRA; pfam07702 446468010303 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 446468010304 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 446468010305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468010306 Zn2+ binding site [ion binding]; other site 446468010307 Mg2+ binding site [ion binding]; other site 446468010308 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 446468010309 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446468010310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468010311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468010312 DNA binding residues [nucleotide binding] 446468010313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468010314 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 446468010315 ThiC-associated domain; Region: ThiC-associated; pfam13667 446468010316 ThiC family; Region: ThiC; pfam01964 446468010317 Uncharacterized conserved protein [Function unknown]; Region: COG2135 446468010318 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 446468010319 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 446468010320 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 446468010321 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446468010322 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 446468010323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468010324 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446468010325 active site 446468010326 oxyanion hole [active] 446468010327 catalytic triad [active] 446468010328 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446468010329 Interdomain contacts; other site 446468010330 Cytokine receptor motif; other site 446468010331 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446468010332 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468010333 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 446468010334 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 446468010335 active site 446468010336 dimer interface [polypeptide binding]; other site 446468010337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468010338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468010339 active site 446468010340 catalytic tetrad [active] 446468010341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 446468010342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468010343 S-adenosylmethionine binding site [chemical binding]; other site 446468010344 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468010345 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468010346 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 446468010347 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 446468010348 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446468010349 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 446468010350 SmpB-tmRNA interface; other site 446468010351 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 446468010352 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 446468010353 FtsX-like permease family; Region: FtsX; pfam02687 446468010354 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 446468010355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468010356 Walker A/P-loop; other site 446468010357 ATP binding site [chemical binding]; other site 446468010358 Q-loop/lid; other site 446468010359 ABC transporter signature motif; other site 446468010360 Walker B; other site 446468010361 D-loop; other site 446468010362 H-loop/switch region; other site 446468010363 peptide chain release factor 2; Validated; Region: prfB; PRK00578 446468010364 This domain is found in peptide chain release factors; Region: PCRF; smart00937 446468010365 RF-1 domain; Region: RF-1; pfam00472 446468010366 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 446468010367 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 446468010368 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 446468010369 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 446468010370 epoxide hydrolase N-terminal domain-like phosphatase; Region: HAD-1A3-hyp; TIGR02247 446468010371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468010372 motif II; other site 446468010373 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 446468010374 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446468010375 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 446468010376 HPr interaction site; other site 446468010377 glycerol kinase (GK) interaction site [polypeptide binding]; other site 446468010378 active site 446468010379 phosphorylation site [posttranslational modification] 446468010380 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 446468010381 active site turn [active] 446468010382 phosphorylation site [posttranslational modification] 446468010383 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 446468010384 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446468010385 dimer interface [polypeptide binding]; other site 446468010386 active site 446468010387 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446468010388 dimer interface [polypeptide binding]; other site 446468010389 active site 446468010390 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468010391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468010392 DNA-binding site [nucleotide binding]; DNA binding site 446468010393 UTRA domain; Region: UTRA; pfam07702 446468010394 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 446468010395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468010396 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 446468010397 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 446468010398 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468010399 putative DNA binding site [nucleotide binding]; other site 446468010400 putative Zn2+ binding site [ion binding]; other site 446468010401 AsnC family; Region: AsnC_trans_reg; pfam01037 446468010402 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 446468010403 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 446468010404 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 446468010405 nucleotide binding region [chemical binding]; other site 446468010406 SEC-C motif; Region: SEC-C; pfam02810 446468010407 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 446468010408 30S subunit binding site; other site 446468010409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468010410 active site 446468010411 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 446468010412 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446468010413 lipoprotein LpqB; Provisional; Region: PRK13613 446468010414 Sporulation and spore germination; Region: Germane; pfam10646 446468010415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468010416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468010417 dimerization interface [polypeptide binding]; other site 446468010418 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468010419 dimer interface [polypeptide binding]; other site 446468010420 phosphorylation site [posttranslational modification] 446468010421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468010422 ATP binding site [chemical binding]; other site 446468010423 Mg2+ binding site [ion binding]; other site 446468010424 G-X-G motif; other site 446468010425 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468010426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468010427 active site 446468010428 phosphorylation site [posttranslational modification] 446468010429 intermolecular recognition site; other site 446468010430 dimerization interface [polypeptide binding]; other site 446468010431 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468010432 DNA binding site [nucleotide binding] 446468010433 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 446468010434 MoxR-like ATPases [General function prediction only]; Region: COG0714 446468010435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468010436 Walker A motif; other site 446468010437 ATP binding site [chemical binding]; other site 446468010438 Walker B motif; other site 446468010439 arginine finger; other site 446468010440 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446468010441 Protein of unknown function DUF58; Region: DUF58; pfam01882 446468010442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446468010443 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468010444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468010445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468010446 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 446468010447 RDD family; Region: RDD; pfam06271 446468010448 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 446468010449 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446468010450 homotetramer interface [polypeptide binding]; other site 446468010451 ligand binding site [chemical binding]; other site 446468010452 catalytic site [active] 446468010453 NAD binding site [chemical binding]; other site 446468010454 Adenosylhomocysteinase; Provisional; Region: PTZ00075 446468010455 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 446468010456 homotetramer interface [polypeptide binding]; other site 446468010457 ligand binding site [chemical binding]; other site 446468010458 catalytic site [active] 446468010459 NAD binding site [chemical binding]; other site 446468010460 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468010461 DNA binding residues [nucleotide binding] 446468010462 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468010463 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468010464 active site 446468010465 ATP binding site [chemical binding]; other site 446468010466 substrate binding site [chemical binding]; other site 446468010467 activation loop (A-loop); other site 446468010468 Uncharacterized conserved protein [Function unknown]; Region: COG2835 446468010469 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 446468010470 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 446468010471 active site 446468010472 substrate binding site [chemical binding]; other site 446468010473 metal binding site [ion binding]; metal-binding site 446468010474 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 446468010475 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 446468010476 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446468010477 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 446468010478 Probable Catalytic site; other site 446468010479 metal-binding site 446468010480 Transcription factor WhiB; Region: Whib; pfam02467 446468010481 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 446468010482 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 446468010483 phosphate binding site [ion binding]; other site 446468010484 dimer interface [polypeptide binding]; other site 446468010485 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 446468010486 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 446468010487 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 446468010488 putative FMN binding site [chemical binding]; other site 446468010489 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 446468010490 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 446468010491 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 446468010492 putative active site [active] 446468010493 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 446468010494 aromatic chitin/cellulose binding site residues [chemical binding]; other site 446468010495 FO synthase; Reviewed; Region: fbiC; PRK09234 446468010496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468010497 FeS/SAM binding site; other site 446468010498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468010499 FeS/SAM binding site; other site 446468010500 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 446468010501 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 446468010502 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468010503 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 446468010504 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 446468010505 Ligand binding site; other site 446468010506 Putative Catalytic site; other site 446468010507 DXD motif; other site 446468010508 TIGR03089 family protein; Region: TIGR03089 446468010509 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 446468010510 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 446468010511 active site 446468010512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468010513 non-specific DNA binding site [nucleotide binding]; other site 446468010514 salt bridge; other site 446468010515 sequence-specific DNA binding site [nucleotide binding]; other site 446468010516 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446468010517 active site 446468010518 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 446468010519 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 446468010520 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468010521 catalytic residue [active] 446468010522 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 446468010523 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 446468010524 hinge; other site 446468010525 active site 446468010526 Predicted GTPases [General function prediction only]; Region: COG1162 446468010527 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446468010528 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446468010529 GTP/Mg2+ binding site [chemical binding]; other site 446468010530 G4 box; other site 446468010531 G1 box; other site 446468010532 Switch I region; other site 446468010533 G2 box; other site 446468010534 G3 box; other site 446468010535 Switch II region; other site 446468010536 Predicted transcriptional regulators [Transcription]; Region: COG1733 446468010537 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468010538 dimerization interface [polypeptide binding]; other site 446468010539 putative DNA binding site [nucleotide binding]; other site 446468010540 putative Zn2+ binding site [ion binding]; other site 446468010541 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 446468010542 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 446468010543 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 446468010544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468010545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468010546 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 446468010547 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 446468010548 active site 446468010549 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 446468010550 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446468010551 FtsX-like permease family; Region: FtsX; pfam02687 446468010552 HlyD family secretion protein; Region: HlyD_3; pfam13437 446468010553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468010554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468010555 Walker A/P-loop; other site 446468010556 ATP binding site [chemical binding]; other site 446468010557 Q-loop/lid; other site 446468010558 ABC transporter signature motif; other site 446468010559 Walker B; other site 446468010560 D-loop; other site 446468010561 H-loop/switch region; other site 446468010562 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 446468010563 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 446468010564 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 446468010565 protein binding site [polypeptide binding]; other site 446468010566 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 446468010567 MoaE homodimer interface [polypeptide binding]; other site 446468010568 MoaD interaction [polypeptide binding]; other site 446468010569 active site residues [active] 446468010570 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468010571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468010572 NAD(P) binding site [chemical binding]; other site 446468010573 active site 446468010574 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446468010575 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446468010576 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 446468010577 nudix motif; other site 446468010578 Protein of unknown function DUF45; Region: DUF45; pfam01863 446468010579 Transcription factor WhiB; Region: Whib; pfam02467 446468010580 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446468010581 Part of AAA domain; Region: AAA_19; pfam13245 446468010582 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446468010583 Family description; Region: UvrD_C_2; pfam13538 446468010584 HRDC domain; Region: HRDC; pfam00570 446468010585 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 446468010586 catalytic residues [active] 446468010587 ANTAR domain; Region: ANTAR; pfam03861 446468010588 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 446468010589 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 446468010590 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 446468010591 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 446468010592 putative NADH binding site [chemical binding]; other site 446468010593 putative active site [active] 446468010594 nudix motif; other site 446468010595 putative metal binding site [ion binding]; other site 446468010596 hypothetical protein; Provisional; Region: PRK08201 446468010597 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 446468010598 metal binding site [ion binding]; metal-binding site 446468010599 putative dimer interface [polypeptide binding]; other site 446468010600 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 446468010601 EF-hand domain pair; Region: EF_hand_5; pfam13499 446468010602 Ca2+ binding site [ion binding]; other site 446468010603 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 446468010604 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 446468010605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010606 dimer interface [polypeptide binding]; other site 446468010607 conserved gate region; other site 446468010608 putative PBP binding loops; other site 446468010609 ABC-ATPase subunit interface; other site 446468010610 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 446468010611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468010612 dimer interface [polypeptide binding]; other site 446468010613 conserved gate region; other site 446468010614 putative PBP binding loops; other site 446468010615 ABC-ATPase subunit interface; other site 446468010616 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 446468010617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468010618 Walker A/P-loop; other site 446468010619 ATP binding site [chemical binding]; other site 446468010620 Q-loop/lid; other site 446468010621 ABC transporter signature motif; other site 446468010622 Walker B; other site 446468010623 D-loop; other site 446468010624 H-loop/switch region; other site 446468010625 TOBE domain; Region: TOBE_2; pfam08402 446468010626 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 446468010627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468010628 motif II; other site 446468010629 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 446468010630 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468010631 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468010632 DNA-binding site [nucleotide binding]; DNA binding site 446468010633 UTRA domain; Region: UTRA; pfam07702 446468010634 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446468010635 Part of AAA domain; Region: AAA_19; pfam13245 446468010636 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446468010637 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 446468010638 Part of AAA domain; Region: AAA_19; pfam13245 446468010639 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 446468010640 Family description; Region: UvrD_C_2; pfam13538 446468010641 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 446468010642 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 446468010643 active site 446468010644 DNA binding site [nucleotide binding] 446468010645 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 446468010646 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 446468010647 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 446468010648 ATP binding site [chemical binding]; other site 446468010649 substrate interface [chemical binding]; other site 446468010650 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446468010651 active site residue [active] 446468010652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468010653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468010654 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 446468010655 dinuclear metal binding motif [ion binding]; other site 446468010656 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446468010657 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468010658 ATP binding site [chemical binding]; other site 446468010659 Mg++ binding site [ion binding]; other site 446468010660 motif III; other site 446468010661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468010662 nucleotide binding region [chemical binding]; other site 446468010663 ATP-binding site [chemical binding]; other site 446468010664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468010665 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468010666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468010667 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 446468010668 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446468010669 active site 446468010670 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 446468010671 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 446468010672 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 446468010673 G1 box; other site 446468010674 putative GEF interaction site [polypeptide binding]; other site 446468010675 GTP/Mg2+ binding site [chemical binding]; other site 446468010676 Switch I region; other site 446468010677 G2 box; other site 446468010678 G3 box; other site 446468010679 Switch II region; other site 446468010680 G4 box; other site 446468010681 G5 box; other site 446468010682 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 446468010683 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 446468010684 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 446468010685 active site 446468010686 8-oxo-dGMP binding site [chemical binding]; other site 446468010687 nudix motif; other site 446468010688 metal binding site [ion binding]; metal-binding site 446468010689 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 446468010690 AAA domain; Region: AAA_30; pfam13604 446468010691 Family description; Region: UvrD_C_2; pfam13538 446468010692 Protein of unknown function (DUF419); Region: DUF419; pfam04237 446468010693 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468010694 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468010695 active site 446468010696 ATP binding site [chemical binding]; other site 446468010697 substrate binding site [chemical binding]; other site 446468010698 activation loop (A-loop); other site 446468010699 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 446468010700 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468010701 active site 446468010702 metal binding site [ion binding]; metal-binding site 446468010703 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 446468010704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468010705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468010706 active site 446468010707 phosphorylation site [posttranslational modification] 446468010708 intermolecular recognition site; other site 446468010709 dimerization interface [polypeptide binding]; other site 446468010710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468010711 DNA binding site [nucleotide binding] 446468010712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468010713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468010714 dimer interface [polypeptide binding]; other site 446468010715 phosphorylation site [posttranslational modification] 446468010716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468010717 ATP binding site [chemical binding]; other site 446468010718 Mg2+ binding site [ion binding]; other site 446468010719 G-X-G motif; other site 446468010720 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446468010721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468010722 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 446468010723 active site 446468010724 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 446468010725 homodimer interface [polypeptide binding]; other site 446468010726 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 446468010727 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 446468010728 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 446468010729 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446468010730 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 446468010731 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 446468010732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468010733 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 446468010734 putative FMN binding site [chemical binding]; other site 446468010735 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468010736 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 446468010737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446468010738 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468010739 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 446468010740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468010741 ATP binding site [chemical binding]; other site 446468010742 Mg2+ binding site [ion binding]; other site 446468010743 G-X-G motif; other site 446468010744 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 446468010745 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 446468010746 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 446468010747 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446468010748 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468010749 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468010750 MarR family; Region: MarR; pfam01047 446468010751 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468010752 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 446468010753 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 446468010754 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 446468010755 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 446468010756 active site 446468010757 metal binding site [ion binding]; metal-binding site 446468010758 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 446468010759 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 446468010760 active site 446468010761 metal-binding site 446468010762 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 446468010763 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 446468010764 Walker A/P-loop; other site 446468010765 ATP binding site [chemical binding]; other site 446468010766 Q-loop/lid; other site 446468010767 ABC transporter signature motif; other site 446468010768 Walker B; other site 446468010769 D-loop; other site 446468010770 H-loop/switch region; other site 446468010771 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 446468010772 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446468010773 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 446468010774 substrate binding site; other site 446468010775 dimer interface; other site 446468010776 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 446468010777 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 446468010778 active site 446468010779 metal binding site [ion binding]; metal-binding site 446468010780 catalytic site [active] 446468010781 Short C-terminal domain; Region: SHOCT; pfam09851 446468010782 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 446468010783 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446468010784 Ligand binding site; other site 446468010785 TM2 domain; Region: TM2; pfam05154 446468010786 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446468010787 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 446468010788 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 446468010789 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 446468010790 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446468010791 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 446468010792 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446468010793 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 446468010794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468010795 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468010796 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468010797 AIR carboxylase; Region: AIRC; pfam00731 446468010798 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 446468010799 ATP-grasp domain; Region: ATP-grasp; pfam02222 446468010800 Predicted membrane protein [Function unknown]; Region: COG2246 446468010801 GtrA-like protein; Region: GtrA; pfam04138 446468010802 CAAX protease self-immunity; Region: Abi; pfam02517 446468010803 Domain of unknown function DUF59; Region: DUF59; cl00941 446468010804 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446468010805 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 446468010806 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468010807 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 446468010808 Putative zinc-finger; Region: zf-HC2; pfam13490 446468010809 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 446468010810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468010811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468010812 DNA binding residues [nucleotide binding] 446468010813 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 446468010814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468010815 S-adenosylmethionine binding site [chemical binding]; other site 446468010816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468010817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468010818 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 446468010819 interface (dimer of trimers) [polypeptide binding]; other site 446468010820 multifunctional aminopeptidase A; Provisional; Region: PRK00913 446468010821 Substrate-binding/catalytic site; other site 446468010822 Zn-binding sites [ion binding]; other site 446468010823 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 446468010824 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 446468010825 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 446468010826 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 446468010827 metal binding site [ion binding]; metal-binding site 446468010828 putative dimer interface [polypeptide binding]; other site 446468010829 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 446468010830 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 446468010831 trimer interface [polypeptide binding]; other site 446468010832 active site 446468010833 substrate binding site [chemical binding]; other site 446468010834 CoA binding site [chemical binding]; other site 446468010835 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 446468010836 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468010837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468010838 homodimer interface [polypeptide binding]; other site 446468010839 catalytic residue [active] 446468010840 Ferredoxin [Energy production and conversion]; Region: COG1146 446468010841 4Fe-4S binding domain; Region: Fer4; pfam00037 446468010842 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 446468010843 Peptidase family M50; Region: Peptidase_M50; pfam02163 446468010844 active site 446468010845 putative substrate binding region [chemical binding]; other site 446468010846 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 446468010847 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 446468010848 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 446468010849 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468010850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468010851 active site 446468010852 ATP binding site [chemical binding]; other site 446468010853 substrate binding site [chemical binding]; other site 446468010854 activation loop (A-loop); other site 446468010855 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468010856 active site 446468010857 ATP binding site [chemical binding]; other site 446468010858 substrate binding site [chemical binding]; other site 446468010859 activation loop (A-loop); other site 446468010860 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 446468010861 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446468010862 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468010863 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 446468010864 Arc-like DNA binding domain; Region: Arc; pfam03869 446468010865 Fic/DOC family; Region: Fic; cl00960 446468010866 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 446468010867 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 446468010868 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 446468010869 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 446468010870 L-aspartate oxidase; Provisional; Region: PRK06175 446468010871 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446468010872 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 446468010873 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 446468010874 putative Iron-sulfur protein interface [polypeptide binding]; other site 446468010875 proximal heme binding site [chemical binding]; other site 446468010876 distal heme binding site [chemical binding]; other site 446468010877 putative dimer interface [polypeptide binding]; other site 446468010878 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468010879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468010880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446468010881 dimerization interface [polypeptide binding]; other site 446468010882 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 446468010883 L-aspartate oxidase; Provisional; Region: PRK06175 446468010884 L-aspartate oxidase; Provisional; Region: PRK06175 446468010885 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446468010886 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 446468010887 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446468010888 catalytic loop [active] 446468010889 iron binding site [ion binding]; other site 446468010890 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468010891 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468010892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468010893 non-specific DNA binding site [nucleotide binding]; other site 446468010894 salt bridge; other site 446468010895 sequence-specific DNA binding site [nucleotide binding]; other site 446468010896 T5orf172 domain; Region: T5orf172; cl17462 446468010897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468010898 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 446468010899 cyclase homology domain; Region: CHD; cd07302 446468010900 nucleotidyl binding site; other site 446468010901 metal binding site [ion binding]; metal-binding site 446468010902 dimer interface [polypeptide binding]; other site 446468010903 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 446468010904 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 446468010905 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 446468010906 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468010907 putative active site [active] 446468010908 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 446468010909 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 446468010910 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 446468010911 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 446468010912 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 446468010913 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 446468010914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 446468010915 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468010916 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 446468010917 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 446468010918 carboxyltransferase (CT) interaction site; other site 446468010919 biotinylation site [posttranslational modification]; other site 446468010920 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 446468010921 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 446468010922 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468010923 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468010924 active site 446468010925 AAA domain; Region: AAA_17; pfam13207 446468010926 AAA domain; Region: AAA_18; pfam13238 446468010927 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 446468010928 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 446468010929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468010930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468010931 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446468010932 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 446468010933 putative active site pocket [active] 446468010934 dimerization interface [polypeptide binding]; other site 446468010935 putative catalytic residue [active] 446468010936 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 446468010937 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 446468010938 adenosine deaminase; Provisional; Region: PRK09358 446468010939 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446468010940 active site 446468010941 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 446468010942 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 446468010943 metal binding site [ion binding]; metal-binding site 446468010944 putative dimer interface [polypeptide binding]; other site 446468010945 carboxylate-amine ligase; Provisional; Region: PRK13517 446468010946 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446468010947 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 446468010948 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446468010949 galactokinase; Provisional; Region: PRK00555 446468010950 Transcriptional regulator [Transcription]; Region: LytR; COG1316 446468010951 isocitrate dehydrogenase; Validated; Region: PRK08299 446468010952 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 446468010953 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446468010954 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446468010955 phosphopeptide binding site; other site 446468010956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468010957 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 446468010958 DNA binding residues [nucleotide binding] 446468010959 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 446468010960 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 446468010961 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 446468010962 homodimer interface [polypeptide binding]; other site 446468010963 NADP binding site [chemical binding]; other site 446468010964 substrate binding site [chemical binding]; other site 446468010965 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 446468010966 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 446468010967 purine monophosphate binding site [chemical binding]; other site 446468010968 dimer interface [polypeptide binding]; other site 446468010969 putative catalytic residues [active] 446468010970 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 446468010971 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 446468010972 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 446468010973 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 446468010974 active site 446468010975 substrate binding site [chemical binding]; other site 446468010976 cosubstrate binding site; other site 446468010977 catalytic site [active] 446468010978 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 446468010979 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 446468010980 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 446468010981 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 446468010982 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446468010983 active site 446468010984 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 446468010985 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468010986 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 446468010987 Coenzyme A binding pocket [chemical binding]; other site 446468010988 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 446468010989 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 446468010990 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 446468010991 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 446468010992 calcium binding site 2 [ion binding]; other site 446468010993 active site 446468010994 catalytic triad [active] 446468010995 calcium binding site 1 [ion binding]; other site 446468010996 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 446468010997 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 446468010998 CysD dimerization site [polypeptide binding]; other site 446468010999 G1 box; other site 446468011000 putative GEF interaction site [polypeptide binding]; other site 446468011001 GTP/Mg2+ binding site [chemical binding]; other site 446468011002 Switch I region; other site 446468011003 G2 box; other site 446468011004 G3 box; other site 446468011005 Switch II region; other site 446468011006 G4 box; other site 446468011007 G5 box; other site 446468011008 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 446468011009 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 446468011010 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 446468011011 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 446468011012 Active Sites [active] 446468011013 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 446468011014 active site 446468011015 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 446468011016 Bacterial sugar transferase; Region: Bac_transf; pfam02397 446468011017 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 446468011018 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 446468011019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011021 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 446468011022 active site 446468011023 catalytic triad [active] 446468011024 oxyanion hole [active] 446468011025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468011026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468011027 DNA binding site [nucleotide binding] 446468011028 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 446468011029 putative dimerization interface [polypeptide binding]; other site 446468011030 putative ligand binding site [chemical binding]; other site 446468011031 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 446468011032 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 446468011033 putative active site [active] 446468011034 catalytic residue [active] 446468011035 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 446468011036 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 446468011037 5S rRNA interface [nucleotide binding]; other site 446468011038 CTC domain interface [polypeptide binding]; other site 446468011039 L16 interface [polypeptide binding]; other site 446468011040 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 446468011041 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 446468011042 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468011043 active site 446468011044 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 446468011045 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 446468011046 Substrate binding site; other site 446468011047 Mg++ binding site; other site 446468011048 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 446468011049 active site 446468011050 substrate binding site [chemical binding]; other site 446468011051 CoA binding site [chemical binding]; other site 446468011052 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 446468011053 Fatty acid desaturase; Region: FA_desaturase; pfam00487 446468011054 Di-iron ligands [ion binding]; other site 446468011055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011057 MarR family; Region: MarR_2; cl17246 446468011058 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468011059 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 446468011060 active site 446468011061 catalytic triad [active] 446468011062 oxyanion hole [active] 446468011063 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 446468011064 catalytic residues [active] 446468011065 dimer interface [polypeptide binding]; other site 446468011066 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468011067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468011068 ABC transporter; Region: ABC_tran_2; pfam12848 446468011069 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468011070 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 446468011071 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 446468011072 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 446468011073 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 446468011074 putative NAD(P) binding site [chemical binding]; other site 446468011075 catalytic Zn binding site [ion binding]; other site 446468011076 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468011077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468011078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468011079 dimer interface [polypeptide binding]; other site 446468011080 conserved gate region; other site 446468011081 putative PBP binding loops; other site 446468011082 ABC-ATPase subunit interface; other site 446468011083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468011084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468011085 putative PBP binding loops; other site 446468011086 ABC-ATPase subunit interface; other site 446468011087 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 446468011088 PYR/PP interface [polypeptide binding]; other site 446468011089 dimer interface [polypeptide binding]; other site 446468011090 TPP binding site [chemical binding]; other site 446468011091 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468011092 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 446468011093 TPP-binding site [chemical binding]; other site 446468011094 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 446468011095 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468011096 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468011097 active site 446468011098 ATP binding site [chemical binding]; other site 446468011099 substrate binding site [chemical binding]; other site 446468011100 activation loop (A-loop); other site 446468011101 GMP synthase; Reviewed; Region: guaA; PRK00074 446468011102 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 446468011103 AMP/PPi binding site [chemical binding]; other site 446468011104 candidate oxyanion hole; other site 446468011105 catalytic triad [active] 446468011106 potential glutamine specificity residues [chemical binding]; other site 446468011107 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 446468011108 ATP Binding subdomain [chemical binding]; other site 446468011109 Ligand Binding sites [chemical binding]; other site 446468011110 Dimerization subdomain; other site 446468011111 UDP-glucose 4-epimerase; Region: PLN02240 446468011112 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 446468011113 NAD binding site [chemical binding]; other site 446468011114 homodimer interface [polypeptide binding]; other site 446468011115 active site 446468011116 substrate binding site [chemical binding]; other site 446468011117 Histidine kinase; Region: HisKA_3; pfam07730 446468011118 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468011119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468011120 active site 446468011121 phosphorylation site [posttranslational modification] 446468011122 intermolecular recognition site; other site 446468011123 dimerization interface [polypeptide binding]; other site 446468011124 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468011125 DNA binding residues [nucleotide binding] 446468011126 dimerization interface [polypeptide binding]; other site 446468011127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468011128 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446468011129 Walker A/P-loop; other site 446468011130 ATP binding site [chemical binding]; other site 446468011131 Q-loop/lid; other site 446468011132 ABC transporter signature motif; other site 446468011133 Walker B; other site 446468011134 D-loop; other site 446468011135 H-loop/switch region; other site 446468011136 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446468011137 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446468011138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 446468011139 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 446468011140 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 446468011141 generic binding surface I; other site 446468011142 generic binding surface II; other site 446468011143 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 446468011144 putative active site [active] 446468011145 putative catalytic site [active] 446468011146 putative Mg binding site IVb [ion binding]; other site 446468011147 putative phosphate binding site [ion binding]; other site 446468011148 putative DNA binding site [nucleotide binding]; other site 446468011149 putative Mg binding site IVa [ion binding]; other site 446468011150 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 446468011151 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468011152 active site 446468011153 metal binding site [ion binding]; metal-binding site 446468011154 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 446468011155 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 446468011156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468011157 S-adenosylmethionine binding site [chemical binding]; other site 446468011158 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468011159 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 446468011160 intersubunit interface [polypeptide binding]; other site 446468011161 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 446468011162 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 446468011163 N-acetyl-D-glucosamine binding site [chemical binding]; other site 446468011164 catalytic residue [active] 446468011165 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 446468011166 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446468011167 active site 446468011168 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 446468011169 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 446468011170 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 446468011171 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 446468011172 active site 446468011173 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 446468011174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468011175 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468011176 DNA binding residues [nucleotide binding] 446468011177 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446468011178 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446468011179 ring oligomerisation interface [polypeptide binding]; other site 446468011180 ATP/Mg binding site [chemical binding]; other site 446468011181 stacking interactions; other site 446468011182 hinge regions; other site 446468011183 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 446468011184 oligomerisation interface [polypeptide binding]; other site 446468011185 mobile loop; other site 446468011186 roof hairpin; other site 446468011187 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468011188 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 446468011189 NAD(P) binding site [chemical binding]; other site 446468011190 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 446468011191 nudix motif; other site 446468011192 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 446468011193 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 446468011194 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468011195 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468011196 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468011197 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468011198 5-dehydro-4-deoxyglucarate dehydratase; Provisional; Region: PRK03620 446468011199 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 446468011200 catalytic residue [active] 446468011201 fructuronate transporter; Provisional; Region: PRK10034; cl15264 446468011202 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 446468011203 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 446468011204 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 446468011205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468011206 Coenzyme A binding pocket [chemical binding]; other site 446468011207 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 446468011208 Glycoprotease family; Region: Peptidase_M22; pfam00814 446468011209 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 446468011210 alanine racemase; Reviewed; Region: alr; PRK00053 446468011211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446468011212 active site 446468011213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468011214 dimer interface [polypeptide binding]; other site 446468011215 substrate binding site [chemical binding]; other site 446468011216 catalytic residues [active] 446468011217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468011218 putative DNA binding site [nucleotide binding]; other site 446468011219 putative Zn2+ binding site [ion binding]; other site 446468011220 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468011221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468011222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468011223 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468011224 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468011225 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446468011226 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 446468011227 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 446468011228 Walker A/P-loop; other site 446468011229 ATP binding site [chemical binding]; other site 446468011230 Q-loop/lid; other site 446468011231 ABC transporter signature motif; other site 446468011232 Walker B; other site 446468011233 D-loop; other site 446468011234 H-loop/switch region; other site 446468011235 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 446468011236 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468011237 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468011238 TM-ABC transporter signature motif; other site 446468011239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468011240 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 446468011241 TM-ABC transporter signature motif; other site 446468011242 Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300 446468011243 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 446468011244 putative ligand binding site [chemical binding]; other site 446468011245 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446468011246 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 446468011247 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 446468011248 sensor kinase CusS; Provisional; Region: PRK09835 446468011249 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 446468011250 active site clefts [active] 446468011251 zinc binding site [ion binding]; other site 446468011252 dimer interface [polypeptide binding]; other site 446468011253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011255 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 446468011256 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 446468011257 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 446468011258 ribosome small subunit-dependent GTPase A; Region: TIGR00157 446468011259 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 446468011260 GTPase/Zn-binding domain interface [polypeptide binding]; other site 446468011261 GTP/Mg2+ binding site [chemical binding]; other site 446468011262 G4 box; other site 446468011263 G5 box; other site 446468011264 G1 box; other site 446468011265 Switch I region; other site 446468011266 G2 box; other site 446468011267 G3 box; other site 446468011268 Switch II region; other site 446468011269 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 446468011270 active site 446468011271 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 446468011272 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 446468011273 active site 446468011274 HIGH motif; other site 446468011275 KMSKS motif; other site 446468011276 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 446468011277 tRNA binding surface [nucleotide binding]; other site 446468011278 anticodon binding site; other site 446468011279 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 446468011280 Protein export membrane protein; Region: SecD_SecF; cl14618 446468011281 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 446468011282 Protein export membrane protein; Region: SecD_SecF; pfam02355 446468011283 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 446468011284 Predicted methyltransferases [General function prediction only]; Region: COG0313 446468011285 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 446468011286 putative SAM binding site [chemical binding]; other site 446468011287 putative homodimer interface [polypeptide binding]; other site 446468011288 RRXRR protein; Region: RRXRR; pfam14239 446468011289 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468011290 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 446468011291 active site 446468011292 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 446468011293 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468011294 DNA-binding site [nucleotide binding]; DNA binding site 446468011295 RNA-binding motif; other site 446468011296 sec-independent translocase; Provisional; Region: PRK01371 446468011297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468011298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468011299 active site 446468011300 phosphorylation site [posttranslational modification] 446468011301 intermolecular recognition site; other site 446468011302 dimerization interface [polypeptide binding]; other site 446468011303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468011304 DNA binding residues [nucleotide binding] 446468011305 dimerization interface [polypeptide binding]; other site 446468011306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011307 WHG domain; Region: WHG; pfam13305 446468011308 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468011309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468011310 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 446468011311 MPT binding site; other site 446468011312 trimer interface [polypeptide binding]; other site 446468011313 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 446468011314 trimer interface [polypeptide binding]; other site 446468011315 dimer interface [polypeptide binding]; other site 446468011316 putative active site [active] 446468011317 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 446468011318 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 446468011319 dimer interface [polypeptide binding]; other site 446468011320 putative functional site; other site 446468011321 putative MPT binding site; other site 446468011322 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 446468011323 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 446468011324 active site 446468011325 tetramer interface; other site 446468011326 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 446468011327 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 446468011328 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 446468011329 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 446468011330 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 446468011331 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 446468011332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011333 hypothetical protein; Provisional; Region: PRK07588 446468011334 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468011335 hypothetical protein; Provisional; Region: PRK07236 446468011336 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 446468011337 PLD-like domain; Region: PLDc_2; pfam13091 446468011338 putative active site [active] 446468011339 catalytic site [active] 446468011340 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 446468011341 PLD-like domain; Region: PLDc_2; pfam13091 446468011342 putative active site [active] 446468011343 catalytic site [active] 446468011344 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468011345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468011346 S-adenosylmethionine binding site [chemical binding]; other site 446468011347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 446468011348 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 446468011349 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 446468011350 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 446468011351 Leucine-rich repeats; other site 446468011352 Sulfatase; Region: Sulfatase; cl17466 446468011353 coproporphyrinogen III oxidase; Validated; Region: PRK08208 446468011354 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468011355 FeS/SAM binding site; other site 446468011356 HemN C-terminal domain; Region: HemN_C; pfam06969 446468011357 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468011358 FeS/SAM binding site; other site 446468011359 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 446468011360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468011361 active site 446468011362 motif I; other site 446468011363 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 446468011364 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468011365 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468011366 DNA-binding site [nucleotide binding]; DNA binding site 446468011367 FCD domain; Region: FCD; pfam07729 446468011368 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 446468011369 MPT binding site; other site 446468011370 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 446468011371 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 446468011372 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 446468011373 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446468011374 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468011375 molybdopterin cofactor binding site; other site 446468011376 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 446468011377 molybdopterin cofactor binding site; other site 446468011378 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446468011379 putative dimer interface [polypeptide binding]; other site 446468011380 [2Fe-2S] cluster binding site [ion binding]; other site 446468011381 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 446468011382 SLBB domain; Region: SLBB; pfam10531 446468011383 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 446468011384 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446468011385 catalytic loop [active] 446468011386 iron binding site [ion binding]; other site 446468011387 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 446468011388 4Fe-4S binding domain; Region: Fer4; pfam00037 446468011389 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468011390 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 446468011391 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 446468011392 CoA binding domain; Region: CoA_binding; smart00881 446468011393 CoA-ligase; Region: Ligase_CoA; pfam00549 446468011394 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 446468011395 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 446468011396 CoA-ligase; Region: Ligase_CoA; pfam00549 446468011397 hypothetical protein; Provisional; Region: PRK05858 446468011398 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 446468011399 PYR/PP interface [polypeptide binding]; other site 446468011400 dimer interface [polypeptide binding]; other site 446468011401 TPP binding site [chemical binding]; other site 446468011402 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 446468011403 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 446468011404 TPP-binding site; other site 446468011405 dimer interface [polypeptide binding]; other site 446468011406 formyl-coenzyme A transferase; Provisional; Region: PRK05398 446468011407 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468011408 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 446468011409 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 446468011410 CoA binding domain; Region: CoA_binding_2; pfam13380 446468011411 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 446468011412 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446468011413 Protein of unknown function, DUF485; Region: DUF485; pfam04341 446468011414 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 446468011415 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 446468011416 Na binding site [ion binding]; other site 446468011417 Histidine kinase; Region: His_kinase; pfam06580 446468011418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468011419 ATP binding site [chemical binding]; other site 446468011420 Mg2+ binding site [ion binding]; other site 446468011421 G-X-G motif; other site 446468011422 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 446468011423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468011424 active site 446468011425 phosphorylation site [posttranslational modification] 446468011426 intermolecular recognition site; other site 446468011427 dimerization interface [polypeptide binding]; other site 446468011428 LytTr DNA-binding domain; Region: LytTR; smart00850 446468011429 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446468011430 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 446468011431 Na binding site [ion binding]; other site 446468011432 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 446468011433 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 446468011434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468011435 NAD(P) binding site [chemical binding]; other site 446468011436 active site 446468011437 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468011438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468011439 ATP binding site [chemical binding]; other site 446468011440 Mg2+ binding site [ion binding]; other site 446468011441 G-X-G motif; other site 446468011442 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468011443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468011444 non-specific DNA binding site [nucleotide binding]; other site 446468011445 salt bridge; other site 446468011446 sequence-specific DNA binding site [nucleotide binding]; other site 446468011447 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468011448 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468011449 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468011450 Mg2+ binding site [ion binding]; other site 446468011451 G-X-G motif; other site 446468011452 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 446468011453 RHS Repeat; Region: RHS_repeat; pfam05593 446468011454 RHS Repeat; Region: RHS_repeat; cl11982 446468011455 RHS Repeat; Region: RHS_repeat; cl11982 446468011456 RHS Repeat; Region: RHS_repeat; pfam05593 446468011457 RHS Repeat; Region: RHS_repeat; cl11982 446468011458 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 446468011459 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 446468011460 active site 446468011461 substrate-binding site [chemical binding]; other site 446468011462 metal-binding site [ion binding] 446468011463 GTP binding site [chemical binding]; other site 446468011464 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 446468011465 Part of AAA domain; Region: AAA_19; pfam13245 446468011466 pantothenate kinase; Provisional; Region: PRK05439 446468011467 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 446468011468 ATP-binding site [chemical binding]; other site 446468011469 CoA-binding site [chemical binding]; other site 446468011470 Mg2+-binding site [ion binding]; other site 446468011471 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 446468011472 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 446468011473 glutaminase active site [active] 446468011474 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 446468011475 dimer interface [polypeptide binding]; other site 446468011476 active site 446468011477 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 446468011478 dimer interface [polypeptide binding]; other site 446468011479 active site 446468011480 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468011481 anti sigma factor interaction site; other site 446468011482 regulatory phosphorylation site [posttranslational modification]; other site 446468011483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446468011484 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468011485 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468011486 non-specific DNA binding site [nucleotide binding]; other site 446468011487 salt bridge; other site 446468011488 sequence-specific DNA binding site [nucleotide binding]; other site 446468011489 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468011490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 446468011491 Radical SAM superfamily; Region: Radical_SAM; pfam04055 446468011492 FeS/SAM binding site; other site 446468011493 putative phosphate acyltransferase; Provisional; Region: PRK05331 446468011494 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 446468011495 arginine-tRNA ligase; Region: PLN02286 446468011496 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 446468011497 active site 446468011498 HIGH motif; other site 446468011499 KMSK motif region; other site 446468011500 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 446468011501 tRNA binding surface [nucleotide binding]; other site 446468011502 anticodon binding site; other site 446468011503 YceI-like domain; Region: YceI; pfam04264 446468011504 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468011505 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 446468011506 substrate binding site [chemical binding]; other site 446468011507 dimer interface [polypeptide binding]; other site 446468011508 ATP binding site [chemical binding]; other site 446468011509 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 446468011510 putative catalytic site [active] 446468011511 putative phosphate binding site [ion binding]; other site 446468011512 active site 446468011513 metal binding site A [ion binding]; metal-binding site 446468011514 DNA binding site [nucleotide binding] 446468011515 putative AP binding site [nucleotide binding]; other site 446468011516 putative metal binding site B [ion binding]; other site 446468011517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 446468011518 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446468011519 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 446468011520 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 446468011521 dimer interface [polypeptide binding]; other site 446468011522 active site 446468011523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011524 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 446468011525 putative substrate translocation pore; other site 446468011526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468011528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468011529 active site 446468011530 PAS fold; Region: PAS_3; pfam08447 446468011531 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468011532 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446468011533 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468011534 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468011535 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 446468011536 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 446468011537 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 446468011538 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 446468011539 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468011540 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446468011541 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 446468011542 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 446468011543 ligand binding site [chemical binding]; other site 446468011544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 446468011545 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468011546 catalytic residue [active] 446468011547 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 446468011548 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446468011549 active site 446468011550 catalytic site [active] 446468011551 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 446468011552 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 446468011553 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 446468011554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011556 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 446468011557 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 446468011558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468011559 S-adenosylmethionine binding site [chemical binding]; other site 446468011560 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 446468011561 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 446468011562 MOSC domain; Region: MOSC; pfam03473 446468011563 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 446468011564 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468011565 DNA-binding site [nucleotide binding]; DNA binding site 446468011566 RNA-binding motif; other site 446468011567 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 446468011568 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 446468011569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468011570 nucleotide binding region [chemical binding]; other site 446468011571 ATP-binding site [chemical binding]; other site 446468011572 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 446468011573 active site 446468011574 diiron metal binding site [ion binding]; other site 446468011575 Zeta toxin; Region: Zeta_toxin; pfam06414 446468011576 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 446468011577 Cellulose binding domain; Region: CBM_2; pfam00553 446468011578 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 446468011579 nudix motif; other site 446468011580 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468011581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468011582 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 446468011583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468011584 ABC transporter signature motif; other site 446468011585 Walker B; other site 446468011586 D-loop; other site 446468011587 H-loop/switch region; other site 446468011588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468011589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468011590 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 446468011591 Walker A/P-loop; other site 446468011592 ATP binding site [chemical binding]; other site 446468011593 Q-loop/lid; other site 446468011594 ABC transporter signature motif; other site 446468011595 Walker B; other site 446468011596 D-loop; other site 446468011597 H-loop/switch region; other site 446468011598 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 446468011599 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 446468011600 ring oligomerisation interface [polypeptide binding]; other site 446468011601 ATP/Mg binding site [chemical binding]; other site 446468011602 stacking interactions; other site 446468011603 hinge regions; other site 446468011604 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468011605 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468011606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468011607 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468011608 Walker A/P-loop; other site 446468011609 ATP binding site [chemical binding]; other site 446468011610 Q-loop/lid; other site 446468011611 ABC transporter signature motif; other site 446468011612 Walker B; other site 446468011613 D-loop; other site 446468011614 H-loop/switch region; other site 446468011615 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468011616 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468011617 putative acetyltransferase; Provisional; Region: PRK03624 446468011618 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468011619 Coenzyme A binding pocket [chemical binding]; other site 446468011620 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 446468011621 MoaE interaction surface [polypeptide binding]; other site 446468011622 MoeB interaction surface [polypeptide binding]; other site 446468011623 thiocarboxylated glycine; other site 446468011624 threonine synthase; Validated; Region: PRK07591 446468011625 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 446468011626 homodimer interface [polypeptide binding]; other site 446468011627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468011628 catalytic residue [active] 446468011629 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 446468011630 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 446468011631 active site 446468011632 homotetramer interface [polypeptide binding]; other site 446468011633 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 446468011634 Methyltransferase domain; Region: Methyltransf_11; pfam08241 446468011635 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 446468011636 active site 446468011637 catalytic residues [active] 446468011638 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 446468011639 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 446468011640 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 446468011641 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468011642 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468011643 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 446468011644 heterotetramer interface [polypeptide binding]; other site 446468011645 active site pocket [active] 446468011646 cleavage site 446468011647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468011648 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 446468011649 NAD(P) binding site [chemical binding]; other site 446468011650 active site 446468011651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468011653 putative substrate translocation pore; other site 446468011654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011655 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468011656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468011658 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468011659 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 446468011660 EF-hand domain pair; Region: EF_hand_5; pfam13499 446468011661 Ca2+ binding site [ion binding]; other site 446468011662 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468011663 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 446468011664 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 446468011665 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446468011666 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 446468011667 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 446468011668 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 446468011669 putative NAD(P) binding site [chemical binding]; other site 446468011670 catalytic Zn binding site [ion binding]; other site 446468011671 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 446468011672 active site 446468011673 phosphorylation site [posttranslational modification] 446468011674 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 446468011675 active site 446468011676 P-loop; other site 446468011677 phosphorylation site [posttranslational modification] 446468011678 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 446468011679 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 446468011680 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468011681 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446468011682 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468011683 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 446468011684 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 446468011685 putative substrate binding site [chemical binding]; other site 446468011686 putative ATP binding site [chemical binding]; other site 446468011687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 446468011688 dimerization domain swap beta strand [polypeptide binding]; other site 446468011689 regulatory protein interface [polypeptide binding]; other site 446468011690 active site 446468011691 regulatory phosphorylation site [posttranslational modification]; other site 446468011692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468011693 NAD(P) binding site [chemical binding]; other site 446468011694 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446468011695 active site 446468011696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468011697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468011698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446468011699 dimerization interface [polypeptide binding]; other site 446468011700 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 446468011701 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 446468011702 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446468011703 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446468011704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468011705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468011706 putative substrate translocation pore; other site 446468011707 Nitronate monooxygenase; Region: NMO; pfam03060 446468011708 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 446468011709 FMN binding site [chemical binding]; other site 446468011710 substrate binding site [chemical binding]; other site 446468011711 putative catalytic residue [active] 446468011712 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446468011713 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 446468011714 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 446468011715 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446468011716 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 446468011717 cofactor binding site; other site 446468011718 DNA binding site [nucleotide binding] 446468011719 substrate interaction site [chemical binding]; other site 446468011720 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446468011721 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 446468011722 GIY-YIG motif/motif A; other site 446468011723 active site 446468011724 catalytic site [active] 446468011725 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468011726 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468011727 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468011728 non-specific DNA binding site [nucleotide binding]; other site 446468011729 salt bridge; other site 446468011730 sequence-specific DNA binding site [nucleotide binding]; other site 446468011731 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468011732 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468011733 Mg2+ binding site [ion binding]; other site 446468011734 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 446468011735 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 446468011736 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 446468011737 active site 446468011738 short chain dehydrogenase; Provisional; Region: PRK06197 446468011739 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 446468011740 putative NAD(P) binding site [chemical binding]; other site 446468011741 active site 446468011742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011744 WHG domain; Region: WHG; pfam13305 446468011745 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 446468011746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468011747 Histidine kinase; Region: HisKA_3; pfam07730 446468011748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468011749 Mg2+ binding site [ion binding]; other site 446468011750 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468011751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468011752 active site 446468011753 phosphorylation site [posttranslational modification] 446468011754 intermolecular recognition site; other site 446468011755 dimerization interface [polypeptide binding]; other site 446468011756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468011757 DNA binding residues [nucleotide binding] 446468011758 dimerization interface [polypeptide binding]; other site 446468011759 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 446468011760 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446468011761 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 446468011762 Walker A/P-loop; other site 446468011763 ATP binding site [chemical binding]; other site 446468011764 Q-loop/lid; other site 446468011765 ABC transporter signature motif; other site 446468011766 Walker B; other site 446468011767 D-loop; other site 446468011768 H-loop/switch region; other site 446468011769 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 446468011770 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 446468011771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468011772 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468011773 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 446468011774 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446468011775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446468011776 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 446468011777 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468011778 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 446468011779 dimerization interface [polypeptide binding]; other site 446468011780 Domain of unknown function (DUF305); Region: DUF305; pfam03713 446468011781 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446468011782 hydrophobic ligand binding site; other site 446468011783 Phosphopantetheine attachment site; Region: PP-binding; cl09936 446468011784 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 446468011785 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 446468011786 active site 446468011787 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 446468011788 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 446468011789 dimer interface [polypeptide binding]; other site 446468011790 active site 446468011791 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 446468011792 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 446468011793 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 446468011794 dimer interface [polypeptide binding]; other site 446468011795 putative PBP binding regions; other site 446468011796 ABC-ATPase subunit interface; other site 446468011797 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 446468011798 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 446468011799 Walker A/P-loop; other site 446468011800 ATP binding site [chemical binding]; other site 446468011801 Q-loop/lid; other site 446468011802 ABC transporter signature motif; other site 446468011803 Walker B; other site 446468011804 D-loop; other site 446468011805 H-loop/switch region; other site 446468011806 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 446468011807 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 446468011808 intersubunit interface [polypeptide binding]; other site 446468011809 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446468011810 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 446468011811 BCCT family transporter; Region: BCCT; cl00569 446468011812 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446468011813 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 446468011814 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 446468011815 DNA binding residues [nucleotide binding] 446468011816 RibD C-terminal domain; Region: RibD_C; cl17279 446468011817 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 446468011818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011819 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468011820 CAAX protease self-immunity; Region: Abi; pfam02517 446468011821 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446468011822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011824 CAAX protease self-immunity; Region: Abi; pfam02517 446468011825 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446468011826 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 446468011827 FMN binding site [chemical binding]; other site 446468011828 active site 446468011829 substrate binding site [chemical binding]; other site 446468011830 catalytic residue [active] 446468011831 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 446468011832 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468011833 DNA binding residues [nucleotide binding] 446468011834 putative dimer interface [polypeptide binding]; other site 446468011835 Transcriptional regulator [Transcription]; Region: LysR; COG0583 446468011836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 446468011837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 446468011838 dimerization interface [polypeptide binding]; other site 446468011839 Predicted membrane protein [Function unknown]; Region: COG4125 446468011840 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 446468011841 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 446468011842 Protein of unknown function (DUF418); Region: DUF418; cl12135 446468011843 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468011844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468011845 DNA-binding site [nucleotide binding]; DNA binding site 446468011846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011848 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468011849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468011850 Walker A/P-loop; other site 446468011851 ATP binding site [chemical binding]; other site 446468011852 Q-loop/lid; other site 446468011853 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 446468011854 dimer interface [polypeptide binding]; other site 446468011855 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468011856 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446468011857 putative NAD(P) binding site [chemical binding]; other site 446468011858 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 446468011859 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 446468011860 putative active site [active] 446468011861 metal binding site [ion binding]; metal-binding site 446468011862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468011863 MarR family; Region: MarR_2; pfam12802 446468011864 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 446468011865 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 446468011866 NAD binding site [chemical binding]; other site 446468011867 catalytic Zn binding site [ion binding]; other site 446468011868 structural Zn binding site [ion binding]; other site 446468011869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 446468011870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011871 CAAX protease self-immunity; Region: Abi; cl00558 446468011872 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 446468011873 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468011874 acyl-activating enzyme (AAE) consensus motif; other site 446468011875 AMP binding site [chemical binding]; other site 446468011876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468011877 Condensation domain; Region: Condensation; pfam00668 446468011878 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468011879 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468011880 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468011881 acyl-activating enzyme (AAE) consensus motif; other site 446468011882 AMP binding site [chemical binding]; other site 446468011883 active site 446468011884 CoA binding site [chemical binding]; other site 446468011885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468011886 Condensation domain; Region: Condensation; pfam00668 446468011887 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 446468011888 Condensation domain; Region: Condensation; pfam00668 446468011889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468011890 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468011891 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468011892 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468011893 acyl-activating enzyme (AAE) consensus motif; other site 446468011894 AMP binding site [chemical binding]; other site 446468011895 active site 446468011896 CoA binding site [chemical binding]; other site 446468011897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468011898 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468011899 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468011900 Condensation domain; Region: Condensation; pfam00668 446468011901 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 446468011902 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468011903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468011904 acyl-activating enzyme (AAE) consensus motif; other site 446468011905 AMP binding site [chemical binding]; other site 446468011906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468011907 Condensation domain; Region: Condensation; pfam00668 446468011908 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 446468011909 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 446468011910 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468011911 acyl-activating enzyme (AAE) consensus motif; other site 446468011912 AMP binding site [chemical binding]; other site 446468011913 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 446468011914 Condensation domain; Region: Condensation; pfam00668 446468011915 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 446468011916 MbtH-like protein; Region: MbtH; pfam03621 446468011917 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 446468011918 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 446468011919 active site 446468011920 DNA binding site [nucleotide binding] 446468011921 Int/Topo IB signature motif; other site 446468011922 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 446468011923 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 446468011924 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 446468011925 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 446468011926 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446468011927 active site 446468011928 HIGH motif; other site 446468011929 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 446468011930 KMSKS motif; other site 446468011931 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 446468011932 tRNA binding surface [nucleotide binding]; other site 446468011933 anticodon binding site; other site 446468011934 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446468011935 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 446468011936 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468011937 NAD(P) binding site [chemical binding]; other site 446468011938 active site 446468011939 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 446468011940 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 446468011941 homotrimer interaction site [polypeptide binding]; other site 446468011942 zinc binding site [ion binding]; other site 446468011943 CDP-binding sites; other site 446468011944 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 446468011945 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 446468011946 PhoU domain; Region: PhoU; pfam01895 446468011947 PhoU domain; Region: PhoU; pfam01895 446468011948 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446468011949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468011950 dimer interface [polypeptide binding]; other site 446468011951 phosphorylation site [posttranslational modification] 446468011952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468011953 ATP binding site [chemical binding]; other site 446468011954 Mg2+ binding site [ion binding]; other site 446468011955 G-X-G motif; other site 446468011956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468011957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468011958 active site 446468011959 phosphorylation site [posttranslational modification] 446468011960 intermolecular recognition site; other site 446468011961 dimerization interface [polypeptide binding]; other site 446468011962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468011963 DNA binding site [nucleotide binding] 446468011964 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 446468011965 putative active site [active] 446468011966 dimerization interface [polypeptide binding]; other site 446468011967 putative tRNAtyr binding site [nucleotide binding]; other site 446468011968 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 446468011969 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446468011970 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 446468011971 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468011972 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 446468011973 nucleophilic elbow; other site 446468011974 catalytic triad; other site 446468011975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468011976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468011977 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 446468011978 Penicillinase repressor; Region: Pencillinase_R; pfam03965 446468011979 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 446468011980 DNA photolyase; Region: DNA_photolyase; pfam00875 446468011981 Protein of unknown function (DUF523); Region: DUF523; pfam04463 446468011982 Uncharacterized conserved protein [Function unknown]; Region: COG3272 446468011983 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 446468011984 Putative esterase; Region: Esterase; pfam00756 446468011985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 446468011986 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446468011987 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 446468011988 putative ADP-binding pocket [chemical binding]; other site 446468011989 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 446468011990 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468011991 catalytic core [active] 446468011992 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468011993 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 446468011994 E3 Ubiquitin ligase; Region: GIDE; pfam12483 446468011995 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 446468011996 heme-binding site [chemical binding]; other site 446468011997 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 446468011998 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 446468011999 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 446468012000 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446468012001 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 446468012002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468012003 non-specific DNA binding site [nucleotide binding]; other site 446468012004 salt bridge; other site 446468012005 sequence-specific DNA binding site [nucleotide binding]; other site 446468012006 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 446468012007 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 446468012008 putative NAD(P) binding site [chemical binding]; other site 446468012009 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 446468012010 catalytic triad [active] 446468012011 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 446468012012 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 446468012013 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 446468012014 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446468012015 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446468012016 active site residue [active] 446468012017 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446468012018 active site residue [active] 446468012019 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446468012020 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446468012021 catalytic residues [active] 446468012022 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 446468012023 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 446468012024 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 446468012025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012026 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446468012027 NAD(P) binding site [chemical binding]; other site 446468012028 active site 446468012029 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468012030 catalytic core [active] 446468012031 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 446468012032 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468012033 inhibitor-cofactor binding pocket; inhibition site 446468012034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468012035 catalytic residue [active] 446468012036 RloB-like protein; Region: RloB; pfam13707 446468012037 AAA domain; Region: AAA_21; pfam13304 446468012038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012039 Walker A/P-loop; other site 446468012040 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 446468012041 ATP binding site [chemical binding]; other site 446468012042 ABC transporter signature motif; other site 446468012043 Walker B; other site 446468012044 D-loop; other site 446468012045 H-loop/switch region; other site 446468012046 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 446468012047 active site 446468012048 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 446468012049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468012050 Histidine kinase; Region: HisKA_3; pfam07730 446468012051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468012052 Mg2+ binding site [ion binding]; other site 446468012053 G-X-G motif; other site 446468012054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012056 active site 446468012057 phosphorylation site [posttranslational modification] 446468012058 intermolecular recognition site; other site 446468012059 dimerization interface [polypeptide binding]; other site 446468012060 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012061 DNA binding residues [nucleotide binding] 446468012062 dimerization interface [polypeptide binding]; other site 446468012063 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446468012064 active site 446468012065 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 446468012066 nucleotide binding site [chemical binding]; other site 446468012067 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 446468012068 dimer interface [polypeptide binding]; other site 446468012069 active site 446468012070 Schiff base residues; other site 446468012071 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 446468012072 active site 446468012073 SAM binding site [chemical binding]; other site 446468012074 homodimer interface [polypeptide binding]; other site 446468012075 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 446468012076 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 446468012077 active site 446468012078 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 446468012079 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 446468012080 domain interfaces; other site 446468012081 active site 446468012082 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 446468012083 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 446468012084 tRNA; other site 446468012085 putative tRNA binding site [nucleotide binding]; other site 446468012086 putative NADP binding site [chemical binding]; other site 446468012087 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 446468012088 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 446468012089 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 446468012090 CoA binding domain; Region: CoA_binding; smart00881 446468012091 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 446468012092 charged pocket; other site 446468012093 Ubiquitin-like proteins; Region: UBQ; cl00155 446468012094 hydrophobic patch; other site 446468012095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468012096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468012097 DNA binding site [nucleotide binding] 446468012098 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 446468012099 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468012100 Coenzyme A binding pocket [chemical binding]; other site 446468012101 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 446468012102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468012103 dimer interface [polypeptide binding]; other site 446468012104 conserved gate region; other site 446468012105 ABC-ATPase subunit interface; other site 446468012106 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446468012107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468012108 dimer interface [polypeptide binding]; other site 446468012109 conserved gate region; other site 446468012110 putative PBP binding loops; other site 446468012111 ABC-ATPase subunit interface; other site 446468012112 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 446468012113 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446468012114 Walker A/P-loop; other site 446468012115 ATP binding site [chemical binding]; other site 446468012116 Q-loop/lid; other site 446468012117 ABC transporter signature motif; other site 446468012118 Walker B; other site 446468012119 D-loop; other site 446468012120 H-loop/switch region; other site 446468012121 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 446468012122 active site 446468012123 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 446468012124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468012125 non-specific DNA binding site [nucleotide binding]; other site 446468012126 salt bridge; other site 446468012127 sequence-specific DNA binding site [nucleotide binding]; other site 446468012128 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 446468012129 amidophosphoribosyltransferase; Provisional; Region: PRK07847 446468012130 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 446468012131 active site 446468012132 tetramer interface [polypeptide binding]; other site 446468012133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468012134 active site 446468012135 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 446468012136 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 446468012137 dimerization interface [polypeptide binding]; other site 446468012138 putative ATP binding site [chemical binding]; other site 446468012139 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468012140 DNA binding residues [nucleotide binding] 446468012141 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 446468012142 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 446468012143 active site 446468012144 metal binding site [ion binding]; metal-binding site 446468012145 DivIVA domain; Region: DivI1A_domain; TIGR03544 446468012146 DivIVA domain; Region: DivI1A_domain; TIGR03544 446468012147 DivIVA domain; Region: DivI1A_domain; TIGR03544 446468012148 Peptidase family M48; Region: Peptidase_M48; cl12018 446468012149 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 446468012150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446468012151 substrate binding pocket [chemical binding]; other site 446468012152 membrane-bound complex binding site; other site 446468012153 hinge residues; other site 446468012154 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446468012155 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446468012156 phosphopeptide binding site; other site 446468012157 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 446468012158 metal ion-dependent adhesion site (MIDAS); other site 446468012159 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446468012160 active site 446468012161 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468012162 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468012163 active site 446468012164 ATP binding site [chemical binding]; other site 446468012165 substrate binding site [chemical binding]; other site 446468012166 activation loop (A-loop); other site 446468012167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468012168 binding surface 446468012169 Tetratricopeptide repeat; Region: TPR_16; pfam13432 446468012170 TPR motif; other site 446468012171 Predicted ATPase [General function prediction only]; Region: COG3911 446468012172 AAA domain; Region: AAA_28; pfam13521 446468012173 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012174 glycosyltransferase, MGT family; Region: MGT; TIGR01426 446468012175 active site 446468012176 TDP-binding site; other site 446468012177 acceptor substrate-binding pocket; other site 446468012178 homodimer interface [polypeptide binding]; other site 446468012179 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 446468012180 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 446468012181 Citrate synthase; Region: Citrate_synt; pfam00285 446468012182 oxalacetate binding site [chemical binding]; other site 446468012183 citrylCoA binding site [chemical binding]; other site 446468012184 coenzyme A binding site [chemical binding]; other site 446468012185 catalytic triad [active] 446468012186 Peptide chain release factor RF-3 [Translation, ribosomal structure and biogenesis]; Region: PrfC; COG4108 446468012187 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 446468012188 G1 box; other site 446468012189 putative GEF interaction site [polypeptide binding]; other site 446468012190 GTP/Mg2+ binding site [chemical binding]; other site 446468012191 Switch I region; other site 446468012192 G2 box; other site 446468012193 G3 box; other site 446468012194 Switch II region; other site 446468012195 G4 box; other site 446468012196 G5 box; other site 446468012197 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 446468012198 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468012199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468012201 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 446468012202 active site 446468012203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012204 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 446468012205 NAD(P) binding site [chemical binding]; other site 446468012206 active site 446468012207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468012208 Histidine kinase; Region: HisKA_3; pfam07730 446468012209 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012211 active site 446468012212 phosphorylation site [posttranslational modification] 446468012213 intermolecular recognition site; other site 446468012214 dimerization interface [polypeptide binding]; other site 446468012215 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012216 DNA binding residues [nucleotide binding] 446468012217 dimerization interface [polypeptide binding]; other site 446468012218 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 446468012219 glutaminase; Provisional; Region: PRK00971 446468012220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468012221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468012222 active site 446468012223 ATP binding site [chemical binding]; other site 446468012224 substrate binding site [chemical binding]; other site 446468012225 activation loop (A-loop); other site 446468012226 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468012227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 446468012228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446468012229 metal-binding site [ion binding] 446468012230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446468012231 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 446468012232 metal-binding site [ion binding] 446468012233 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446468012234 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446468012235 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468012236 Coenzyme A binding pocket [chemical binding]; other site 446468012237 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 446468012238 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 446468012239 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 446468012240 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 446468012241 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 446468012242 [4Fe-4S] binding site [ion binding]; other site 446468012243 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468012244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468012245 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468012246 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 446468012247 molybdopterin cofactor binding site; other site 446468012248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468012249 cyanate transporter; Region: CynX; TIGR00896 446468012250 putative substrate translocation pore; other site 446468012251 RRNA methyltransferase AviRa; Region: AviRa; pfam11599 446468012252 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 446468012253 RNA binding surface [nucleotide binding]; other site 446468012254 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468012255 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468012256 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 446468012257 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446468012258 ATP binding site [chemical binding]; other site 446468012259 active site 446468012260 substrate binding site [chemical binding]; other site 446468012261 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468012262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468012263 DNA-binding site [nucleotide binding]; DNA binding site 446468012264 UTRA domain; Region: UTRA; pfam07702 446468012265 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 446468012266 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 446468012267 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 446468012268 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 446468012269 cofactor binding site; other site 446468012270 DNA binding site [nucleotide binding] 446468012271 substrate interaction site [chemical binding]; other site 446468012272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 446468012273 Walker A motif; other site 446468012274 ATP binding site [chemical binding]; other site 446468012275 Helix-turn-helix domain; Region: HTH_17; pfam12728 446468012276 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 446468012277 active site 446468012278 catalytic residues [active] 446468012279 DNA binding site [nucleotide binding] 446468012280 Int/Topo IB signature motif; other site 446468012281 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468012282 DNA binding site [nucleotide binding] 446468012283 active site 446468012284 Int/Topo IB signature motif; other site 446468012285 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 446468012286 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 446468012287 active site 446468012288 metal binding site [ion binding]; metal-binding site 446468012289 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 446468012290 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468012291 PspC domain; Region: PspC; pfam04024 446468012292 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468012293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012294 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 446468012295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 446468012296 DNA-binding site [nucleotide binding]; DNA binding site 446468012297 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468012298 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 446468012299 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468012300 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 446468012301 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468012302 Predicted flavoprotein [General function prediction only]; Region: COG0431 446468012303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468012304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012305 hypothetical protein; Provisional; Region: PRK07236 446468012306 hypothetical protein; Validated; Region: PRK05868 446468012307 hypothetical protein; Provisional; Region: PRK07236 446468012308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468012309 putative substrate translocation pore; other site 446468012310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468012311 MarR family; Region: MarR; pfam01047 446468012312 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 446468012313 homotrimer interaction site [polypeptide binding]; other site 446468012314 putative active site [active] 446468012315 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 446468012316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468012317 substrate binding site [chemical binding]; other site 446468012318 oxyanion hole (OAH) forming residues; other site 446468012319 trimer interface [polypeptide binding]; other site 446468012320 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 446468012321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012322 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 446468012323 DEAD-like helicases superfamily; Region: DEXDc; smart00487 446468012324 ATP binding site [chemical binding]; other site 446468012325 Mg++ binding site [ion binding]; other site 446468012326 motif III; other site 446468012327 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468012328 nucleotide binding region [chemical binding]; other site 446468012329 ATP-binding site [chemical binding]; other site 446468012330 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 446468012331 DNA-binding site [nucleotide binding]; DNA binding site 446468012332 RNA-binding motif; other site 446468012333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468012334 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012335 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 446468012336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468012337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012338 NAD(P) binding site [chemical binding]; other site 446468012339 active site 446468012340 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 446468012341 dimer interface [polypeptide binding]; other site 446468012342 ADP-ribose binding site [chemical binding]; other site 446468012343 active site 446468012344 nudix motif; other site 446468012345 metal binding site [ion binding]; metal-binding site 446468012346 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 446468012347 Ligand Binding Site [chemical binding]; other site 446468012348 Molecular Tunnel; other site 446468012349 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 446468012350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468012351 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468012352 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468012353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468012354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468012355 non-specific DNA binding site [nucleotide binding]; other site 446468012356 salt bridge; other site 446468012357 sequence-specific DNA binding site [nucleotide binding]; other site 446468012358 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468012359 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468012360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468012361 dimerization interface [polypeptide binding]; other site 446468012362 putative DNA binding site [nucleotide binding]; other site 446468012363 putative Zn2+ binding site [ion binding]; other site 446468012364 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 446468012365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468012366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 446468012367 Coenzyme A binding pocket [chemical binding]; other site 446468012368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446468012369 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446468012370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468012371 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 446468012372 arsenical-resistance protein; Region: acr3; TIGR00832 446468012373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468012374 putative DNA binding site [nucleotide binding]; other site 446468012375 dimerization interface [polypeptide binding]; other site 446468012376 putative Zn2+ binding site [ion binding]; other site 446468012377 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 446468012378 Low molecular weight phosphatase family; Region: LMWPc; cd00115 446468012379 active site 446468012380 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 446468012381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446468012382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446468012383 Walker A/P-loop; other site 446468012384 ATP binding site [chemical binding]; other site 446468012385 Q-loop/lid; other site 446468012386 ABC transporter signature motif; other site 446468012387 Walker B; other site 446468012388 D-loop; other site 446468012389 H-loop/switch region; other site 446468012390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446468012391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 446468012392 NMT1/THI5 like; Region: NMT1; pfam09084 446468012393 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 446468012394 pyrimidine utilization protein A; Region: RutA; TIGR03612 446468012395 active site 446468012396 dimer interface [polypeptide binding]; other site 446468012397 non-prolyl cis peptide bond; other site 446468012398 insertion regions; other site 446468012399 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 446468012400 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468012401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468012402 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468012403 putative substrate translocation pore; other site 446468012404 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 446468012405 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 446468012406 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 446468012407 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 446468012408 transmembrane helices; other site 446468012409 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 446468012410 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 446468012411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468012412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468012413 dimerization interface [polypeptide binding]; other site 446468012414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468012415 dimer interface [polypeptide binding]; other site 446468012416 phosphorylation site [posttranslational modification] 446468012417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468012418 ATP binding site [chemical binding]; other site 446468012419 Mg2+ binding site [ion binding]; other site 446468012420 G-X-G motif; other site 446468012421 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468012422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012423 active site 446468012424 phosphorylation site [posttranslational modification] 446468012425 intermolecular recognition site; other site 446468012426 dimerization interface [polypeptide binding]; other site 446468012427 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468012428 DNA binding site [nucleotide binding] 446468012429 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468012430 AAA ATPase domain; Region: AAA_16; pfam13191 446468012431 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468012432 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468012433 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468012434 DoxX; Region: DoxX; pfam07681 446468012435 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 446468012436 MarR family; Region: MarR_2; pfam12802 446468012437 MarR family; Region: MarR_2; cl17246 446468012438 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 446468012439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468012440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012441 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 446468012442 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446468012443 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 446468012444 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012445 Helix-turn-helix domain; Region: HTH_18; pfam12833 446468012446 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 446468012447 TIGR03086 family protein; Region: TIGR03086 446468012448 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 446468012449 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468012450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468012451 Walker A/P-loop; other site 446468012452 ATP binding site [chemical binding]; other site 446468012453 Q-loop/lid; other site 446468012454 ABC transporter signature motif; other site 446468012455 Walker B; other site 446468012456 D-loop; other site 446468012457 H-loop/switch region; other site 446468012458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 446468012459 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 446468012460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468012461 Walker A/P-loop; other site 446468012462 ATP binding site [chemical binding]; other site 446468012463 Q-loop/lid; other site 446468012464 ABC transporter signature motif; other site 446468012465 Walker B; other site 446468012466 D-loop; other site 446468012467 H-loop/switch region; other site 446468012468 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446468012469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468012470 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 446468012471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468012472 dimer interface [polypeptide binding]; other site 446468012473 conserved gate region; other site 446468012474 putative PBP binding loops; other site 446468012475 ABC-ATPase subunit interface; other site 446468012476 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468012477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468012478 dimer interface [polypeptide binding]; other site 446468012479 conserved gate region; other site 446468012480 putative PBP binding loops; other site 446468012481 ABC-ATPase subunit interface; other site 446468012482 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 446468012483 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468012484 Rhomboid family; Region: Rhomboid; pfam01694 446468012485 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 446468012486 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 446468012487 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 446468012488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468012489 dimer interface [polypeptide binding]; other site 446468012490 conserved gate region; other site 446468012491 ABC-ATPase subunit interface; other site 446468012492 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 446468012493 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 446468012494 Walker A/P-loop; other site 446468012495 ATP binding site [chemical binding]; other site 446468012496 Q-loop/lid; other site 446468012497 ABC transporter signature motif; other site 446468012498 Walker B; other site 446468012499 D-loop; other site 446468012500 H-loop/switch region; other site 446468012501 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 446468012502 trimer interface [polypeptide binding]; other site 446468012503 active site 446468012504 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 446468012505 putative active site [active] 446468012506 putative metal binding residues [ion binding]; other site 446468012507 signature motif; other site 446468012508 putative triphosphate binding site [ion binding]; other site 446468012509 dimer interface [polypeptide binding]; other site 446468012510 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012512 DNA binding residues [nucleotide binding] 446468012513 dimerization interface [polypeptide binding]; other site 446468012514 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468012515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012516 active site 446468012517 phosphorylation site [posttranslational modification] 446468012518 intermolecular recognition site; other site 446468012519 dimerization interface [polypeptide binding]; other site 446468012520 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468012521 DNA binding site [nucleotide binding] 446468012522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468012523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468012524 dimerization interface [polypeptide binding]; other site 446468012525 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468012526 dimer interface [polypeptide binding]; other site 446468012527 phosphorylation site [posttranslational modification] 446468012528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468012529 ATP binding site [chemical binding]; other site 446468012530 Mg2+ binding site [ion binding]; other site 446468012531 G-X-G motif; other site 446468012532 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446468012533 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468012534 Cupin; Region: Cupin_6; pfam12852 446468012535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468012536 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 446468012537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 446468012538 Cytochrome P450; Region: p450; cl12078 446468012539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468012540 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468012541 Cytochrome P450; Region: p450; cl12078 446468012542 Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810 446468012543 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 446468012544 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 446468012545 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 446468012546 Cellulose binding domain; Region: CBM_2; pfam00553 446468012547 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446468012548 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 446468012549 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 446468012550 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 446468012551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468012552 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468012553 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 446468012554 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 446468012555 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446468012556 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446468012557 short chain dehydrogenase; Provisional; Region: PRK07825 446468012558 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 446468012559 putative NAD(P) binding site [chemical binding]; other site 446468012560 active site 446468012561 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 446468012562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468012563 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446468012564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 446468012565 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 446468012566 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 446468012567 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 446468012568 metal ion-dependent adhesion site (MIDAS); other site 446468012569 MoxR-like ATPases [General function prediction only]; Region: COG0714 446468012570 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 446468012571 SWIM zinc finger; Region: SWIM; pfam04434 446468012572 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468012573 Cytochrome P450; Region: p450; cl12078 446468012574 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468012575 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 446468012576 hydroperoxidase II; Provisional; Region: katE; PRK11249 446468012577 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 446468012578 tetramer interface [polypeptide binding]; other site 446468012579 heme binding pocket [chemical binding]; other site 446468012580 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 446468012581 short chain dehydrogenase; Provisional; Region: PRK06701 446468012582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012583 NAD(P) binding site [chemical binding]; other site 446468012584 active site 446468012585 ChaB; Region: ChaB; pfam06150 446468012586 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 446468012587 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468012588 Domain of unknown function (DUF222); Region: DUF222; pfam02720 446468012589 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468012590 active site 446468012591 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468012592 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 446468012593 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 446468012594 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 446468012595 TM-ABC transporter signature motif; other site 446468012596 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 446468012597 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 446468012598 TM-ABC transporter signature motif; other site 446468012599 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 446468012600 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 446468012601 Walker A/P-loop; other site 446468012602 ATP binding site [chemical binding]; other site 446468012603 Q-loop/lid; other site 446468012604 ABC transporter signature motif; other site 446468012605 Walker B; other site 446468012606 D-loop; other site 446468012607 H-loop/switch region; other site 446468012608 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 446468012609 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 446468012610 Walker A/P-loop; other site 446468012611 ATP binding site [chemical binding]; other site 446468012612 Q-loop/lid; other site 446468012613 ABC transporter signature motif; other site 446468012614 Walker B; other site 446468012615 D-loop; other site 446468012616 H-loop/switch region; other site 446468012617 AAA ATPase domain; Region: AAA_16; pfam13191 446468012618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012619 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012620 DNA binding residues [nucleotide binding] 446468012621 dimerization interface [polypeptide binding]; other site 446468012622 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 446468012623 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 446468012624 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 446468012625 putative active cleft [active] 446468012626 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 446468012627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012628 NAD(P) binding site [chemical binding]; other site 446468012629 active site 446468012630 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468012631 Acyltransferase family; Region: Acyl_transf_3; pfam01757 446468012632 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 446468012633 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 446468012634 homodimer interface [polypeptide binding]; other site 446468012635 NAD binding pocket [chemical binding]; other site 446468012636 ATP binding pocket [chemical binding]; other site 446468012637 Mg binding site [ion binding]; other site 446468012638 active-site loop [active] 446468012639 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 446468012640 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 446468012641 Na binding site [ion binding]; other site 446468012642 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446468012643 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468012644 NB-ARC domain; Region: NB-ARC; pfam00931 446468012645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468012646 TPR motif; other site 446468012647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468012648 binding surface 446468012649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 446468012650 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468012651 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 446468012652 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 446468012653 dimer interface [polypeptide binding]; other site 446468012654 putative radical transfer pathway; other site 446468012655 diiron center [ion binding]; other site 446468012656 tyrosyl radical; other site 446468012657 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 446468012658 Class I ribonucleotide reductase; Region: RNR_I; cd01679 446468012659 active site 446468012660 dimer interface [polypeptide binding]; other site 446468012661 catalytic residues [active] 446468012662 effector binding site; other site 446468012663 R2 peptide binding site; other site 446468012664 LabA_like proteins; Region: LabA_like; cd06167 446468012665 putative metal binding site [ion binding]; other site 446468012666 Uncharacterized conserved protein [Function unknown]; Region: COG1432 446468012667 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 446468012668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468012669 DNA binding residues [nucleotide binding] 446468012670 Putative zinc-finger; Region: zf-HC2; pfam13490 446468012671 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446468012672 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 446468012673 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 446468012674 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 446468012675 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446468012676 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468012677 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446468012678 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468012679 RDD family; Region: RDD; pfam06271 446468012680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468012681 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468012682 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 446468012683 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468012684 active site 446468012685 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 446468012686 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 446468012687 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 446468012688 active site 446468012689 intersubunit interface [polypeptide binding]; other site 446468012690 zinc binding site [ion binding]; other site 446468012691 Na+ binding site [ion binding]; other site 446468012692 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 446468012693 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 446468012694 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 446468012695 GDP-binding site [chemical binding]; other site 446468012696 ACT binding site; other site 446468012697 IMP binding site; other site 446468012698 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 446468012699 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 446468012700 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 446468012701 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 446468012702 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 446468012703 ATP binding site [chemical binding]; other site 446468012704 active site 446468012705 substrate binding site [chemical binding]; other site 446468012706 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 446468012707 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 446468012708 hinge; other site 446468012709 active site 446468012710 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 446468012711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468012712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468012713 homodimer interface [polypeptide binding]; other site 446468012714 catalytic residue [active] 446468012715 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 446468012716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468012717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468012718 DNA binding residues [nucleotide binding] 446468012719 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468012720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468012721 DNA-binding site [nucleotide binding]; DNA binding site 446468012722 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468012723 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 446468012724 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 446468012725 putative active site pocket [active] 446468012726 metal binding site [ion binding]; metal-binding site 446468012727 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 446468012728 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 446468012729 transmembrane helices; other site 446468012730 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 446468012731 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468012732 DNA binding residues [nucleotide binding] 446468012733 putative dimer interface [polypeptide binding]; other site 446468012734 HEAT repeats; Region: HEAT_2; pfam13646 446468012735 HEAT repeats; Region: HEAT_2; pfam13646 446468012736 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012738 active site 446468012739 phosphorylation site [posttranslational modification] 446468012740 intermolecular recognition site; other site 446468012741 dimerization interface [polypeptide binding]; other site 446468012742 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012743 DNA binding residues [nucleotide binding] 446468012744 dimerization interface [polypeptide binding]; other site 446468012745 Histidine kinase; Region: HisKA_3; pfam07730 446468012746 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468012747 CAAX protease self-immunity; Region: Abi; pfam02517 446468012748 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 446468012749 Serine hydrolase; Region: Ser_hydrolase; cl17834 446468012750 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468012751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012752 NAD(P) binding site [chemical binding]; other site 446468012753 active site 446468012754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468012755 metabolite-proton symporter; Region: 2A0106; TIGR00883 446468012756 putative substrate translocation pore; other site 446468012757 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 446468012758 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468012759 classical (c) SDRs; Region: SDR_c; cd05233 446468012760 NAD(P) binding site [chemical binding]; other site 446468012761 active site 446468012762 SnoaL-like domain; Region: SnoaL_4; pfam13577 446468012763 Transcriptional regulator [Transcription]; Region: IclR; COG1414 446468012764 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 446468012765 Bacterial transcriptional regulator; Region: IclR; pfam01614 446468012766 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 446468012767 [4Fe-4S] binding site [ion binding]; other site 446468012768 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 446468012769 molybdopterin cofactor binding site; other site 446468012770 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 446468012771 molybdopterin cofactor binding site; other site 446468012772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468012773 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 446468012774 FAD binding domain; Region: FAD_binding_4; pfam01565 446468012775 Berberine and berberine like; Region: BBE; pfam08031 446468012776 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 446468012777 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446468012778 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468012779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012780 active site 446468012781 phosphorylation site [posttranslational modification] 446468012782 intermolecular recognition site; other site 446468012783 dimerization interface [polypeptide binding]; other site 446468012784 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468012785 DNA binding site [nucleotide binding] 446468012786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468012787 dimerization interface [polypeptide binding]; other site 446468012788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468012789 dimer interface [polypeptide binding]; other site 446468012790 phosphorylation site [posttranslational modification] 446468012791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468012792 ATP binding site [chemical binding]; other site 446468012793 Mg2+ binding site [ion binding]; other site 446468012794 G-X-G motif; other site 446468012795 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446468012796 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 446468012797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012798 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 446468012799 Walker A/P-loop; other site 446468012800 ATP binding site [chemical binding]; other site 446468012801 Q-loop/lid; other site 446468012802 ABC transporter signature motif; other site 446468012803 Walker B; other site 446468012804 D-loop; other site 446468012805 H-loop/switch region; other site 446468012806 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468012807 DNA binding residues [nucleotide binding] 446468012808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468012809 non-specific DNA binding site [nucleotide binding]; other site 446468012810 sequence-specific DNA binding site [nucleotide binding]; other site 446468012811 salt bridge; other site 446468012812 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468012813 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 446468012814 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468012815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012816 Walker A/P-loop; other site 446468012817 ATP binding site [chemical binding]; other site 446468012818 Q-loop/lid; other site 446468012819 ABC transporter signature motif; other site 446468012820 Walker B; other site 446468012821 D-loop; other site 446468012822 H-loop/switch region; other site 446468012823 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468012824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468012825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012827 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468012828 NAD(P) binding site [chemical binding]; other site 446468012829 active site 446468012830 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468012831 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468012832 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 446468012833 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468012834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468012835 active site 446468012836 phosphorylation site [posttranslational modification] 446468012837 intermolecular recognition site; other site 446468012838 dimerization interface [polypeptide binding]; other site 446468012839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468012840 DNA binding residues [nucleotide binding] 446468012841 dimerization interface [polypeptide binding]; other site 446468012842 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468012843 Cytochrome P450; Region: p450; cl12078 446468012844 Methyltransferase domain; Region: Methyltransf_24; pfam13578 446468012845 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468012846 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446468012847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012848 Walker A/P-loop; other site 446468012849 ATP binding site [chemical binding]; other site 446468012850 Q-loop/lid; other site 446468012851 ABC transporter signature motif; other site 446468012852 Walker B; other site 446468012853 D-loop; other site 446468012854 H-loop/switch region; other site 446468012855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 446468012856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012857 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468012858 Walker A/P-loop; other site 446468012859 ATP binding site [chemical binding]; other site 446468012860 Q-loop/lid; other site 446468012861 ABC transporter signature motif; other site 446468012862 Walker B; other site 446468012863 D-loop; other site 446468012864 H-loop/switch region; other site 446468012865 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 446468012866 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446468012867 active site 446468012868 zinc binding site [ion binding]; other site 446468012869 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 446468012870 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 446468012871 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 446468012872 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 446468012873 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 446468012874 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446468012875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468012876 inhibitor-cofactor binding pocket; inhibition site 446468012877 catalytic residue [active] 446468012878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468012879 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468012880 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012881 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012882 homodimer interface [polypeptide binding]; other site 446468012883 active site 446468012884 TDP-binding site; other site 446468012885 acceptor substrate-binding pocket; other site 446468012886 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012887 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012888 homodimer interface [polypeptide binding]; other site 446468012889 active site 446468012890 TDP-binding site; other site 446468012891 acceptor substrate-binding pocket; other site 446468012892 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468012893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468012894 Walker A/P-loop; other site 446468012895 ATP binding site [chemical binding]; other site 446468012896 Q-loop/lid; other site 446468012897 ABC transporter signature motif; other site 446468012898 Walker B; other site 446468012899 D-loop; other site 446468012900 H-loop/switch region; other site 446468012901 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446468012902 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 446468012903 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 446468012904 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446468012905 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012906 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012907 homodimer interface [polypeptide binding]; other site 446468012908 active site 446468012909 TDP-binding site; other site 446468012910 acceptor substrate-binding pocket; other site 446468012911 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 446468012912 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 446468012913 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 446468012914 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 446468012915 inhibitor-cofactor binding pocket; inhibition site 446468012916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468012917 catalytic residue [active] 446468012918 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 446468012919 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012920 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012921 homodimer interface [polypeptide binding]; other site 446468012922 active site 446468012923 TDP-binding site; other site 446468012924 acceptor substrate-binding pocket; other site 446468012925 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 446468012926 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468012927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468012928 S-adenosylmethionine binding site [chemical binding]; other site 446468012929 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 446468012930 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468012931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468012932 NAD(P) binding site [chemical binding]; other site 446468012933 active site 446468012934 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 446468012935 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 446468012936 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 446468012937 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012938 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012939 homodimer interface [polypeptide binding]; other site 446468012940 active site 446468012941 TDP-binding site; other site 446468012942 acceptor substrate-binding pocket; other site 446468012943 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012944 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012945 homodimer interface [polypeptide binding]; other site 446468012946 active site 446468012947 TDP-binding site; other site 446468012948 acceptor substrate-binding pocket; other site 446468012949 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 446468012950 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 446468012951 active site 446468012952 catalytic tetrad [active] 446468012953 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468012954 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 446468012955 acyl-activating enzyme (AAE) consensus motif; other site 446468012956 AMP binding site [chemical binding]; other site 446468012957 active site 446468012958 CoA binding site [chemical binding]; other site 446468012959 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 446468012960 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 446468012961 active site 446468012962 hypothetical protein; Validated; Region: PRK06840 446468012963 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 446468012964 dimer interface [polypeptide binding]; other site 446468012965 active site 446468012966 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 446468012967 active sites [active] 446468012968 tetramer interface [polypeptide binding]; other site 446468012969 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 446468012970 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 446468012971 AMP binding site [chemical binding]; other site 446468012972 active site 446468012973 acyl-activating enzyme (AAE) consensus motif; other site 446468012974 CoA binding site [chemical binding]; other site 446468012975 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 446468012976 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 446468012977 NAD binding site [chemical binding]; other site 446468012978 substrate binding site [chemical binding]; other site 446468012979 homodimer interface [polypeptide binding]; other site 446468012980 active site 446468012981 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 446468012982 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 446468012983 substrate binding site; other site 446468012984 tetramer interface; other site 446468012985 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012986 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012987 homodimer interface [polypeptide binding]; other site 446468012988 active site 446468012989 TDP-binding site; other site 446468012990 acceptor substrate-binding pocket; other site 446468012991 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 446468012992 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 446468012993 homodimer interface [polypeptide binding]; other site 446468012994 active site 446468012995 TDP-binding site; other site 446468012996 acceptor substrate-binding pocket; other site 446468012997 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468012998 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468012999 active site 446468013000 ATP binding site [chemical binding]; other site 446468013001 substrate binding site [chemical binding]; other site 446468013002 activation loop (A-loop); other site 446468013003 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 446468013004 active site 446468013005 zinc binding site [ion binding]; other site 446468013006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468013007 S-adenosylmethionine binding site [chemical binding]; other site 446468013008 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468013009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013010 Walker A/P-loop; other site 446468013011 ATP binding site [chemical binding]; other site 446468013012 Q-loop/lid; other site 446468013013 ABC transporter signature motif; other site 446468013014 Walker B; other site 446468013015 D-loop; other site 446468013016 H-loop/switch region; other site 446468013017 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468013018 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468013019 ABC-2 type transporter; Region: ABC2_membrane; cl17235 446468013020 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446468013021 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 446468013022 active site 446468013023 intersubunit interface [polypeptide binding]; other site 446468013024 catalytic residue [active] 446468013025 phosphogluconate dehydratase; Validated; Region: PRK09054 446468013026 6-phosphogluconate dehydratase; Region: edd; TIGR01196 446468013027 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 446468013028 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 446468013029 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 446468013030 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468013031 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468013032 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468013033 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 446468013034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468013035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013036 active site 446468013037 phosphorylation site [posttranslational modification] 446468013038 intermolecular recognition site; other site 446468013039 dimerization interface [polypeptide binding]; other site 446468013040 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468013041 DNA binding residues [nucleotide binding] 446468013042 dimerization interface [polypeptide binding]; other site 446468013043 putative amidase; Provisional; Region: PRK06169 446468013044 Amidase; Region: Amidase; pfam01425 446468013045 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 446468013046 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 446468013047 NAD binding site [chemical binding]; other site 446468013048 ligand binding site [chemical binding]; other site 446468013049 catalytic site [active] 446468013050 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 446468013051 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446468013052 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 446468013053 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468013054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468013055 DNA-binding site [nucleotide binding]; DNA binding site 446468013056 FCD domain; Region: FCD; pfam07729 446468013057 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 446468013058 succinic semialdehyde dehydrogenase; Region: PLN02278 446468013059 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 446468013060 tetramerization interface [polypeptide binding]; other site 446468013061 NAD(P) binding site [chemical binding]; other site 446468013062 catalytic residues [active] 446468013063 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 446468013064 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468013065 inhibitor-cofactor binding pocket; inhibition site 446468013066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468013067 catalytic residue [active] 446468013068 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 446468013069 substrate binding pocket [chemical binding]; other site 446468013070 catalytic residues [active] 446468013071 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 446468013072 active site 446468013073 catalytic residues [active] 446468013074 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 446468013075 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 446468013076 FAD binding domain; Region: FAD_binding_4; pfam01565 446468013077 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 446468013078 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446468013079 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 446468013080 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 446468013081 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 446468013082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468013083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468013084 DNA binding residues [nucleotide binding] 446468013085 Asp23 family; Region: Asp23; pfam03780 446468013086 Asp23 family; Region: Asp23; cl00574 446468013087 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 446468013088 ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182 446468013089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013090 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468013091 Walker A/P-loop; other site 446468013092 ATP binding site [chemical binding]; other site 446468013093 Q-loop/lid; other site 446468013094 ABC transporter signature motif; other site 446468013095 Walker B; other site 446468013096 D-loop; other site 446468013097 H-loop/switch region; other site 446468013098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468013099 dimerization interface [polypeptide binding]; other site 446468013100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468013101 dimer interface [polypeptide binding]; other site 446468013102 phosphorylation site [posttranslational modification] 446468013103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013104 ATP binding site [chemical binding]; other site 446468013105 Mg2+ binding site [ion binding]; other site 446468013106 G-X-G motif; other site 446468013107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468013108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013109 active site 446468013110 phosphorylation site [posttranslational modification] 446468013111 intermolecular recognition site; other site 446468013112 dimerization interface [polypeptide binding]; other site 446468013113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468013114 DNA binding site [nucleotide binding] 446468013115 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446468013116 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468013117 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 446468013118 Walker A/P-loop; other site 446468013119 ATP binding site [chemical binding]; other site 446468013120 Q-loop/lid; other site 446468013121 ABC transporter signature motif; other site 446468013122 Walker B; other site 446468013123 D-loop; other site 446468013124 H-loop/switch region; other site 446468013125 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 446468013126 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 446468013127 FtsX-like permease family; Region: FtsX; pfam02687 446468013128 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 446468013129 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 446468013130 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 446468013131 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468013132 dimerization interface [polypeptide binding]; other site 446468013133 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468013134 dimer interface [polypeptide binding]; other site 446468013135 phosphorylation site [posttranslational modification] 446468013136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013137 ATP binding site [chemical binding]; other site 446468013138 Mg2+ binding site [ion binding]; other site 446468013139 G-X-G motif; other site 446468013140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468013141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013142 active site 446468013143 phosphorylation site [posttranslational modification] 446468013144 intermolecular recognition site; other site 446468013145 dimerization interface [polypeptide binding]; other site 446468013146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468013147 DNA binding site [nucleotide binding] 446468013148 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 446468013149 putative metal binding residues [ion binding]; other site 446468013150 signature motif; other site 446468013151 dimer interface [polypeptide binding]; other site 446468013152 active site 446468013153 polyP binding site; other site 446468013154 substrate binding site [chemical binding]; other site 446468013155 acceptor-phosphate pocket; other site 446468013156 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 446468013157 AAA domain; Region: AAA_33; pfam13671 446468013158 active site 446468013159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468013160 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468013161 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 446468013162 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 446468013163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468013164 motif II; other site 446468013165 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 446468013166 hydrophobic ligand binding site; other site 446468013167 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 446468013168 active site 446468013169 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 446468013170 Transcriptional regulators [Transcription]; Region: GntR; COG1802 446468013171 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468013172 DNA-binding site [nucleotide binding]; DNA binding site 446468013173 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 446468013174 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 446468013175 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446468013176 tetramer interface [polypeptide binding]; other site 446468013177 TPP-binding site [chemical binding]; other site 446468013178 heterodimer interface [polypeptide binding]; other site 446468013179 phosphorylation loop region [posttranslational modification] 446468013180 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446468013181 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446468013182 alpha subunit interface [polypeptide binding]; other site 446468013183 TPP binding site [chemical binding]; other site 446468013184 heterodimer interface [polypeptide binding]; other site 446468013185 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468013186 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 446468013187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468013188 E3 interaction surface; other site 446468013189 lipoyl attachment site [posttranslational modification]; other site 446468013190 e3 binding domain; Region: E3_binding; pfam02817 446468013191 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446468013192 Protein of unknown function (DUF952); Region: DUF952; cl01393 446468013193 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 446468013194 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446468013195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468013196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468013197 DNA-binding site [nucleotide binding]; DNA binding site 446468013198 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446468013199 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 446468013200 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 446468013201 aspartate kinase; Reviewed; Region: PRK06635 446468013202 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 446468013203 putative nucleotide binding site [chemical binding]; other site 446468013204 putative catalytic residues [active] 446468013205 putative Mg ion binding site [ion binding]; other site 446468013206 putative aspartate binding site [chemical binding]; other site 446468013207 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 446468013208 putative allosteric regulatory site; other site 446468013209 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 446468013210 putative allosteric regulatory residue; other site 446468013211 recombination protein RecR; Reviewed; Region: recR; PRK00076 446468013212 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 446468013213 RecR protein; Region: RecR; pfam02132 446468013214 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 446468013215 putative active site [active] 446468013216 putative metal-binding site [ion binding]; other site 446468013217 tetramer interface [polypeptide binding]; other site 446468013218 hypothetical protein; Validated; Region: PRK00153 446468013219 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468013220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468013221 S-adenosylmethionine binding site [chemical binding]; other site 446468013222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468013223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468013224 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 446468013225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468013226 Walker A motif; other site 446468013227 ATP binding site [chemical binding]; other site 446468013228 Walker B motif; other site 446468013229 arginine finger; other site 446468013230 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 446468013231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 446468013232 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 446468013233 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 446468013234 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 446468013235 active site 446468013236 FMN binding site [chemical binding]; other site 446468013237 2,4-decadienoyl-CoA binding site; other site 446468013238 catalytic residue [active] 446468013239 4Fe-4S cluster binding site [ion binding]; other site 446468013240 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 446468013241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468013242 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 446468013243 iron-sulfur cluster [ion binding]; other site 446468013244 [2Fe-2S] cluster binding site [ion binding]; other site 446468013245 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468013246 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468013247 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 446468013248 MarR family; Region: MarR_2; pfam12802 446468013249 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468013250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468013251 nucleotide binding site [chemical binding]; other site 446468013252 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 446468013253 Melibiase; Region: Melibiase; pfam02065 446468013254 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 446468013255 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446468013256 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446468013257 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446468013258 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 446468013259 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468013260 ligand binding site [chemical binding]; other site 446468013261 dimerization interface [polypeptide binding]; other site 446468013262 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 446468013263 nucleoside/Zn binding site; other site 446468013264 dimer interface [polypeptide binding]; other site 446468013265 catalytic motif [active] 446468013266 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 446468013267 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 446468013268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468013269 active site 446468013270 Bacterial PH domain; Region: DUF304; pfam03703 446468013271 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 446468013272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013273 Walker A/P-loop; other site 446468013274 ATP binding site [chemical binding]; other site 446468013275 Q-loop/lid; other site 446468013276 ABC transporter signature motif; other site 446468013277 Walker B; other site 446468013278 D-loop; other site 446468013279 H-loop/switch region; other site 446468013280 ABC transporter; Region: ABC_tran_2; pfam12848 446468013281 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 446468013282 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 446468013283 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446468013284 Walker A motif; other site 446468013285 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 446468013286 Homing endonuclease; Region: Hom_end; pfam05204 446468013287 replicative DNA helicase; Region: DnaB; TIGR00665 446468013288 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 446468013289 ATP binding site [chemical binding]; other site 446468013290 Walker B motif; other site 446468013291 DNA binding loops [nucleotide binding] 446468013292 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 446468013293 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 446468013294 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446468013295 substrate binding site [chemical binding]; other site 446468013296 amidase catalytic site [active] 446468013297 Zn binding residues [ion binding]; other site 446468013298 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 446468013299 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 446468013300 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 446468013301 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 446468013302 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 446468013303 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 446468013304 dimer interface [polypeptide binding]; other site 446468013305 ssDNA binding site [nucleotide binding]; other site 446468013306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 446468013307 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 446468013308 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446468013309 Transglycosylase; Region: Transgly; pfam00912 446468013310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446468013311 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 446468013312 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 446468013313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468013314 S-adenosylmethionine binding site [chemical binding]; other site 446468013315 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 446468013316 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 446468013317 active site 446468013318 NTP binding site [chemical binding]; other site 446468013319 metal binding triad [ion binding]; metal-binding site 446468013320 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 446468013321 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 446468013322 Zn2+ binding site [ion binding]; other site 446468013323 Mg2+ binding site [ion binding]; other site 446468013324 integral membrane protein MviN; Region: mviN; TIGR01695 446468013325 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 446468013326 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 446468013327 MviN-like protein; Region: MVIN; pfam03023 446468013328 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 446468013329 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 446468013330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468013331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468013332 DNA binding residues [nucleotide binding] 446468013333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468013334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013335 active site 446468013336 phosphorylation site [posttranslational modification] 446468013337 intermolecular recognition site; other site 446468013338 dimerization interface [polypeptide binding]; other site 446468013339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468013340 DNA binding residues [nucleotide binding] 446468013341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468013342 Histidine kinase; Region: HisKA_3; pfam07730 446468013343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013344 ATP binding site [chemical binding]; other site 446468013345 Mg2+ binding site [ion binding]; other site 446468013346 G-X-G motif; other site 446468013347 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 446468013348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 446468013349 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468013350 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446468013351 catalytic residues [active] 446468013352 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 446468013353 ParB-like nuclease domain; Region: ParB; smart00470 446468013354 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 446468013355 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446468013356 P-loop; other site 446468013357 Magnesium ion binding site [ion binding]; other site 446468013358 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 446468013359 Magnesium ion binding site [ion binding]; other site 446468013360 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 446468013361 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 446468013362 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 446468013363 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 446468013364 G-X-X-G motif; other site 446468013365 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 446468013366 RxxxH motif; other site 446468013367 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446468013368 Haemolytic domain; Region: Haemolytic; pfam01809 446468013369 Ribonuclease P; Region: Ribonuclease_P; cl00457 446468013370 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 446468013371 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 446468013372 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 446468013373 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 446468013374 active site 446468013375 metal binding site [ion binding]; metal-binding site 446468013376 nudix motif; other site 446468013377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468013378 NAD(P) binding site [chemical binding]; other site 446468013379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468013380 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 446468013381 active site 446468013382 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468013383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013384 active site 446468013385 phosphorylation site [posttranslational modification] 446468013386 intermolecular recognition site; other site 446468013387 dimerization interface [polypeptide binding]; other site 446468013388 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468013389 DNA binding residues [nucleotide binding] 446468013390 dimerization interface [polypeptide binding]; other site 446468013391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468013392 Histidine kinase; Region: HisKA_3; pfam07730 446468013393 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468013394 Ubiquitin-like proteins; Region: UBQ; cl00155 446468013395 charged pocket; other site 446468013396 hydrophobic patch; other site 446468013397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468013398 SnoaL-like domain; Region: SnoaL_2; pfam12680 446468013399 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 446468013400 CodY GAF-like domain; Region: CodY; pfam06018 446468013401 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 446468013402 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 446468013403 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 446468013404 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468013405 NAD(P) binding site [chemical binding]; other site 446468013406 catalytic residues [active] 446468013407 Protein of unknown function (DUF779); Region: DUF779; pfam05610 446468013408 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468013409 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468013410 DNA binding residues [nucleotide binding] 446468013411 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 446468013412 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 446468013413 putative dimer interface [polypeptide binding]; other site 446468013414 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 446468013415 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468013416 DNA binding residues [nucleotide binding] 446468013417 putative dimer interface [polypeptide binding]; other site 446468013418 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 446468013419 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 446468013420 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 446468013421 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 446468013422 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468013423 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 446468013424 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 446468013425 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468013426 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 446468013427 MarR family; Region: MarR; pfam01047 446468013428 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446468013429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446468013430 oligomer interface [polypeptide binding]; other site 446468013431 active site residues [active] 446468013432 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 446468013433 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 446468013434 oligomer interface [polypeptide binding]; other site 446468013435 active site residues [active] 446468013436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468013437 non-specific DNA binding site [nucleotide binding]; other site 446468013438 salt bridge; other site 446468013439 sequence-specific DNA binding site [nucleotide binding]; other site 446468013440 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 446468013441 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468013442 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468013443 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 446468013444 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 446468013445 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 446468013446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468013447 NAD(P) binding site [chemical binding]; other site 446468013448 active site 446468013449 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 446468013450 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 446468013451 dimer interface [polypeptide binding]; other site 446468013452 active site 446468013453 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 446468013454 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 446468013455 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 446468013456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468013457 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468013458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013459 dimer interface [polypeptide binding]; other site 446468013460 conserved gate region; other site 446468013461 putative PBP binding loops; other site 446468013462 ABC-ATPase subunit interface; other site 446468013463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468013464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013465 dimer interface [polypeptide binding]; other site 446468013466 conserved gate region; other site 446468013467 putative PBP binding loops; other site 446468013468 ABC-ATPase subunit interface; other site 446468013469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 446468013470 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 446468013471 Probable transposase; Region: OrfB_IS605; pfam01385 446468013472 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 446468013473 Melibiase; Region: Melibiase; pfam02065 446468013474 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 446468013475 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 446468013476 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 446468013477 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 446468013478 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 446468013479 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 446468013480 dimer interface [polypeptide binding]; other site 446468013481 substrate binding site [chemical binding]; other site 446468013482 ATP binding site [chemical binding]; other site 446468013483 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 446468013484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468013485 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468013486 Predicted membrane protein [Function unknown]; Region: COG2311 446468013487 Protein of unknown function (DUF418); Region: DUF418; pfam04235 446468013488 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 446468013489 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 446468013490 heme-binding site [chemical binding]; other site 446468013491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468013492 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468013493 Walker A/P-loop; other site 446468013494 ATP binding site [chemical binding]; other site 446468013495 Q-loop/lid; other site 446468013496 ABC transporter signature motif; other site 446468013497 Walker B; other site 446468013498 D-loop; other site 446468013499 H-loop/switch region; other site 446468013500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468013501 Histidine kinase; Region: HisKA_3; pfam07730 446468013502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013503 ATP binding site [chemical binding]; other site 446468013504 Mg2+ binding site [ion binding]; other site 446468013505 G-X-G motif; other site 446468013506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468013507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013508 active site 446468013509 phosphorylation site [posttranslational modification] 446468013510 intermolecular recognition site; other site 446468013511 dimerization interface [polypeptide binding]; other site 446468013512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468013513 DNA binding residues [nucleotide binding] 446468013514 dimerization interface [polypeptide binding]; other site 446468013515 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446468013516 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446468013517 substrate binding pocket [chemical binding]; other site 446468013518 chain length determination region; other site 446468013519 substrate-Mg2+ binding site; other site 446468013520 catalytic residues [active] 446468013521 aspartate-rich region 1; other site 446468013522 active site lid residues [active] 446468013523 aspartate-rich region 2; other site 446468013524 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 446468013525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013526 Walker A/P-loop; other site 446468013527 ATP binding site [chemical binding]; other site 446468013528 Q-loop/lid; other site 446468013529 ABC transporter signature motif; other site 446468013530 Walker B; other site 446468013531 D-loop; other site 446468013532 H-loop/switch region; other site 446468013533 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 446468013534 putative alpha-glucosidase; Provisional; Region: PRK10658 446468013535 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 446468013536 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 446468013537 active site 446468013538 homotrimer interface [polypeptide binding]; other site 446468013539 catalytic site [active] 446468013540 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 446468013541 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468013542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013543 dimer interface [polypeptide binding]; other site 446468013544 conserved gate region; other site 446468013545 putative PBP binding loops; other site 446468013546 ABC-ATPase subunit interface; other site 446468013547 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 446468013548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013549 dimer interface [polypeptide binding]; other site 446468013550 conserved gate region; other site 446468013551 putative PBP binding loops; other site 446468013552 ABC-ATPase subunit interface; other site 446468013553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468013554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468013555 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468013556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468013557 DNA binding site [nucleotide binding] 446468013558 domain linker motif; other site 446468013559 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 446468013560 aconitate hydratase; Validated; Region: PRK07229 446468013561 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 446468013562 substrate binding site [chemical binding]; other site 446468013563 ligand binding site [chemical binding]; other site 446468013564 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 446468013565 substrate binding site [chemical binding]; other site 446468013566 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446468013567 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 446468013568 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 446468013569 active site 446468013570 iron coordination sites [ion binding]; other site 446468013571 substrate binding pocket [chemical binding]; other site 446468013572 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 446468013573 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 446468013574 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 446468013575 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 446468013576 Walker A/P-loop; other site 446468013577 ATP binding site [chemical binding]; other site 446468013578 Q-loop/lid; other site 446468013579 ABC transporter signature motif; other site 446468013580 Walker B; other site 446468013581 D-loop; other site 446468013582 H-loop/switch region; other site 446468013583 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 446468013584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013585 putative PBP binding loops; other site 446468013586 ABC-ATPase subunit interface; other site 446468013587 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 446468013588 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 446468013589 active site 446468013590 non-prolyl cis peptide bond; other site 446468013591 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 446468013592 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 446468013593 Cytochrome P450; Region: p450; cl12078 446468013594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 446468013595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468013596 dimerization interface [polypeptide binding]; other site 446468013597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468013598 dimer interface [polypeptide binding]; other site 446468013599 phosphorylation site [posttranslational modification] 446468013600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013601 ATP binding site [chemical binding]; other site 446468013602 G-X-G motif; other site 446468013603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468013604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468013605 active site 446468013606 phosphorylation site [posttranslational modification] 446468013607 intermolecular recognition site; other site 446468013608 dimerization interface [polypeptide binding]; other site 446468013609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468013610 DNA binding site [nucleotide binding] 446468013611 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 446468013612 cleavage site 446468013613 active site 446468013614 substrate binding sites [chemical binding]; other site 446468013615 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468013616 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 446468013617 hypothetical protein; Provisional; Region: PRK07906 446468013618 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 446468013619 putative metal binding site [ion binding]; other site 446468013620 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 446468013621 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 446468013622 active site 446468013623 interdomain interaction site; other site 446468013624 putative metal-binding site [ion binding]; other site 446468013625 nucleotide binding site [chemical binding]; other site 446468013626 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 446468013627 domain I; other site 446468013628 phosphate binding site [ion binding]; other site 446468013629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 446468013630 domain II; other site 446468013631 domain III; other site 446468013632 nucleotide binding site [chemical binding]; other site 446468013633 DNA binding groove [nucleotide binding] 446468013634 catalytic site [active] 446468013635 domain IV; other site 446468013636 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446468013637 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446468013638 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 446468013639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468013640 thymidylate kinase; Validated; Region: tmk; PRK00698 446468013641 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 446468013642 TMP-binding site; other site 446468013643 ATP-binding site [chemical binding]; other site 446468013644 DNA polymerase III subunit delta'; Validated; Region: PRK07940 446468013645 DNA polymerase III subunit delta'; Validated; Region: PRK08485 446468013646 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 446468013647 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468013648 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 446468013649 active site 446468013650 catalytic site [active] 446468013651 substrate binding site [chemical binding]; other site 446468013652 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 446468013653 dimer interface [polypeptide binding]; other site 446468013654 substrate binding site [chemical binding]; other site 446468013655 metal binding sites [ion binding]; metal-binding site 446468013656 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 446468013657 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 446468013658 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 446468013659 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 446468013660 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 446468013661 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 446468013662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 446468013663 active site 446468013664 FtsH Extracellular; Region: FtsH_ext; pfam06480 446468013665 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 446468013666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468013667 Walker A motif; other site 446468013668 ATP binding site [chemical binding]; other site 446468013669 Walker B motif; other site 446468013670 arginine finger; other site 446468013671 Peptidase family M41; Region: Peptidase_M41; pfam01434 446468013672 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 446468013673 homodecamer interface [polypeptide binding]; other site 446468013674 GTP cyclohydrolase I; Provisional; Region: PLN03044 446468013675 active site 446468013676 putative catalytic site residues [active] 446468013677 zinc binding site [ion binding]; other site 446468013678 GTP-CH-I/GFRP interaction surface; other site 446468013679 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 446468013680 dihydropteroate synthase; Region: DHPS; TIGR01496 446468013681 substrate binding pocket [chemical binding]; other site 446468013682 dimer interface [polypeptide binding]; other site 446468013683 inhibitor binding site; inhibition site 446468013684 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 446468013685 SnoaL-like domain; Region: SnoaL_3; pfam13474 446468013686 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 446468013687 homooctamer interface [polypeptide binding]; other site 446468013688 active site 446468013689 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 446468013690 catalytic center binding site [active] 446468013691 ATP binding site [chemical binding]; other site 446468013692 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 446468013693 Bacterial PH domain; Region: DUF304; cl01348 446468013694 Bacterial PH domain; Region: DUF304; pfam03703 446468013695 Bacterial PH domain; Region: DUF304; pfam03703 446468013696 Rossmann-like domain; Region: Rossmann-like; pfam10727 446468013697 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 446468013698 Pantoate-beta-alanine ligase; Region: PanC; cd00560 446468013699 pantoate--beta-alanine ligase; Region: panC; TIGR00018 446468013700 active site 446468013701 ATP-binding site [chemical binding]; other site 446468013702 pantoate-binding site; other site 446468013703 HXXH motif; other site 446468013704 L-aspartate oxidase; Provisional; Region: PRK07804 446468013705 L-aspartate oxidase; Provisional; Region: PRK06175 446468013706 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 446468013707 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 446468013708 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 446468013709 dimerization interface [polypeptide binding]; other site 446468013710 active site 446468013711 pantothenate kinase; Reviewed; Region: PRK13318 446468013712 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 446468013713 putative active site [active] 446468013714 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 446468013715 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 446468013716 Cation efflux family; Region: Cation_efflux; pfam01545 446468013717 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 446468013718 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 446468013719 dimer interface [polypeptide binding]; other site 446468013720 putative anticodon binding site; other site 446468013721 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 446468013722 motif 1; other site 446468013723 dimer interface [polypeptide binding]; other site 446468013724 active site 446468013725 motif 2; other site 446468013726 motif 3; other site 446468013727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 446468013728 dimerization interface [polypeptide binding]; other site 446468013729 DNA binding residues [nucleotide binding] 446468013730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468013731 Coenzyme A binding pocket [chemical binding]; other site 446468013732 Lsr2; Region: Lsr2; pfam11774 446468013733 Clp protease ATP binding subunit; Region: clpC; CHL00095 446468013734 Clp amino terminal domain; Region: Clp_N; pfam02861 446468013735 Clp amino terminal domain; Region: Clp_N; pfam02861 446468013736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468013737 Walker A motif; other site 446468013738 ATP binding site [chemical binding]; other site 446468013739 Walker B motif; other site 446468013740 arginine finger; other site 446468013741 UvrB/uvrC motif; Region: UVR; pfam02151 446468013742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468013743 Walker A motif; other site 446468013744 ATP binding site [chemical binding]; other site 446468013745 Walker B motif; other site 446468013746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446468013747 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 446468013748 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 446468013749 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446468013750 minor groove reading motif; other site 446468013751 helix-hairpin-helix signature motif; other site 446468013752 substrate binding pocket [chemical binding]; other site 446468013753 active site 446468013754 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 446468013755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468013756 catalytic core [active] 446468013757 Subtilisin inhibitor-like; Region: SSI; cl11594 446468013758 DNA repair protein RadA; Provisional; Region: PRK11823 446468013759 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446468013760 Walker A motif; other site 446468013761 ATP binding site [chemical binding]; other site 446468013762 Walker B motif; other site 446468013763 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 446468013764 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 446468013765 active site 446468013766 catalytic triad [active] 446468013767 oxyanion hole [active] 446468013768 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468013769 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468013770 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 446468013771 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 446468013772 pyrroline-5-carboxylate reductase; Region: PLN02688 446468013773 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 446468013774 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 446468013775 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 446468013776 active site 446468013777 Zn binding site [ion binding]; other site 446468013778 DNA binding domain, excisionase family; Region: excise; TIGR01764 446468013779 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 446468013780 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446468013781 catalytic residues [active] 446468013782 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 446468013783 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 446468013784 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 446468013785 ResB-like family; Region: ResB; pfam05140 446468013786 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 446468013787 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468013788 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468013789 DNA binding site [nucleotide binding] 446468013790 domain linker motif; other site 446468013791 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468013792 dimerization interface [polypeptide binding]; other site 446468013793 ligand binding site [chemical binding]; other site 446468013794 Amb_all domain; Region: Amb_all; smart00656 446468013795 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 446468013796 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 446468013797 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 446468013798 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468013799 DNA binding residues [nucleotide binding] 446468013800 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468013801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 446468013802 dimerization interface [polypeptide binding]; other site 446468013803 putative DNA binding site [nucleotide binding]; other site 446468013804 Transcriptional regulators [Transcription]; Region: MarR; COG1846 446468013805 putative Zn2+ binding site [ion binding]; other site 446468013806 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 446468013807 hypothetical protein; Provisional; Region: PRK07538 446468013808 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 446468013809 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 446468013810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468013811 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 446468013812 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 446468013813 ParB-like nuclease domain; Region: ParBc; pfam02195 446468013814 Phenazine biosynthesis protein A/B; Region: PHZA_PHZB; pfam03284 446468013815 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 446468013816 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 446468013817 Isochorismatase family; Region: Isochorismatase; pfam00857 446468013818 catalytic triad [active] 446468013819 conserved cis-peptide bond; other site 446468013820 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 446468013821 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 446468013822 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 446468013823 Glutamine amidotransferase class-I; Region: GATase; pfam00117 446468013824 glutamine binding [chemical binding]; other site 446468013825 catalytic triad [active] 446468013826 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 446468013827 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 446468013828 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 446468013829 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 446468013830 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 446468013831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 446468013832 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 446468013833 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 446468013834 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446468013835 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468013836 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468013837 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468013838 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468013839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468013840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468013841 non-specific DNA binding site [nucleotide binding]; other site 446468013842 salt bridge; other site 446468013843 sequence-specific DNA binding site [nucleotide binding]; other site 446468013844 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468013845 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468013846 Mg2+ binding site [ion binding]; other site 446468013847 Protein of unknown function, DUF600; Region: DUF600; cl04640 446468013848 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 446468013849 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 446468013850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468013851 S-adenosylmethionine binding site [chemical binding]; other site 446468013852 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 446468013853 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468013854 NADH dehydrogenase subunit A; Validated; Region: PRK07928 446468013855 NADH dehydrogenase subunit B; Validated; Region: PRK06411 446468013856 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 446468013857 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 446468013858 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 446468013859 NADH dehydrogenase subunit D; Validated; Region: PRK06075 446468013860 NADH dehydrogenase subunit E; Validated; Region: PRK07539 446468013861 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 446468013862 putative dimer interface [polypeptide binding]; other site 446468013863 [2Fe-2S] cluster binding site [ion binding]; other site 446468013864 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 446468013865 SLBB domain; Region: SLBB; pfam10531 446468013866 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 446468013867 NADH dehydrogenase subunit G; Validated; Region: PRK07860 446468013868 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 446468013869 catalytic loop [active] 446468013870 iron binding site [ion binding]; other site 446468013871 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 446468013872 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468013873 molybdopterin cofactor binding site; other site 446468013874 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 446468013875 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 446468013876 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 446468013877 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 446468013878 4Fe-4S binding domain; Region: Fer4; pfam00037 446468013879 4Fe-4S binding domain; Region: Fer4; pfam00037 446468013880 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 446468013881 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 446468013882 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 446468013883 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 446468013884 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 446468013885 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468013886 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 446468013887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468013888 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 446468013889 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 446468013890 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 446468013891 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 446468013892 substrate binding pocket [chemical binding]; other site 446468013893 chain length determination region; other site 446468013894 substrate-Mg2+ binding site; other site 446468013895 catalytic residues [active] 446468013896 aspartate-rich region 1; other site 446468013897 active site lid residues [active] 446468013898 aspartate-rich region 2; other site 446468013899 Predicted permeases [General function prediction only]; Region: RarD; COG2962 446468013900 EamA-like transporter family; Region: EamA; cl17759 446468013901 methionine sulfoxide reductase A; Provisional; Region: PRK00058 446468013902 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468013903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013904 putative PBP binding loops; other site 446468013905 dimer interface [polypeptide binding]; other site 446468013906 ABC-ATPase subunit interface; other site 446468013907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468013908 dimer interface [polypeptide binding]; other site 446468013909 conserved gate region; other site 446468013910 putative PBP binding loops; other site 446468013911 ABC-ATPase subunit interface; other site 446468013912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468013913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 446468013914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468013915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468013916 DNA binding site [nucleotide binding] 446468013917 domain linker motif; other site 446468013918 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468013919 dimerization interface [polypeptide binding]; other site 446468013920 ligand binding site [chemical binding]; other site 446468013921 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 446468013922 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 446468013923 active site 446468013924 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 446468013925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 446468013926 putative active site [active] 446468013927 heme pocket [chemical binding]; other site 446468013928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468013929 ATP binding site [chemical binding]; other site 446468013930 Mg2+ binding site [ion binding]; other site 446468013931 G-X-G motif; other site 446468013932 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 446468013933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446468013934 active site 446468013935 dimerization interface [polypeptide binding]; other site 446468013936 HTH domain; Region: HTH_11; pfam08279 446468013937 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468013938 putative active site [active] 446468013939 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 446468013940 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468013941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 446468013942 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 446468013943 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468013944 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468013945 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 446468013946 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468013947 Coenzyme A binding pocket [chemical binding]; other site 446468013948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468013949 NADH(P)-binding; Region: NAD_binding_10; pfam13460 446468013950 NAD(P) binding site [chemical binding]; other site 446468013951 active site 446468013952 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 446468013953 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 446468013954 TPP-binding site [chemical binding]; other site 446468013955 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 446468013956 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 446468013957 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 446468013958 dimer interface [polypeptide binding]; other site 446468013959 PYR/PP interface [polypeptide binding]; other site 446468013960 TPP binding site [chemical binding]; other site 446468013961 substrate binding site [chemical binding]; other site 446468013962 Peptidase family M48; Region: Peptidase_M48; cl12018 446468013963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 446468013964 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 446468013965 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 446468013966 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 446468013967 TIGR02680 family protein; Region: TIGR02680 446468013968 TIGR02680 family protein; Region: TIGR02680 446468013969 TIGR02680 family protein; Region: TIGR02680 446468013970 TIGR02680 family protein; Region: TIGR02680 446468013971 AAA domain; Region: AAA_23; pfam13476 446468013972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013973 Walker A/P-loop; other site 446468013974 ATP binding site [chemical binding]; other site 446468013975 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468013976 ABC transporter signature motif; other site 446468013977 Walker B; other site 446468013978 D-loop; other site 446468013979 H-loop/switch region; other site 446468013980 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 446468013981 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 446468013982 active site 446468013983 catalytic site [active] 446468013984 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 446468013985 active site 446468013986 catalytic site [active] 446468013987 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 446468013988 FAD binding domain; Region: FAD_binding_4; pfam01565 446468013989 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 446468013990 Predicted membrane protein [Function unknown]; Region: COG2119 446468013991 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446468013992 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 446468013993 adenosine deaminase; Provisional; Region: PRK09358 446468013994 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446468013995 active site 446468013996 aspartate aminotransferase; Provisional; Region: PRK05764 446468013997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 446468013998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468013999 homodimer interface [polypeptide binding]; other site 446468014000 catalytic residue [active] 446468014001 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 446468014002 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 446468014003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 446468014004 putative homodimer interface [polypeptide binding]; other site 446468014005 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 446468014006 heterodimer interface [polypeptide binding]; other site 446468014007 homodimer interface [polypeptide binding]; other site 446468014008 Ribosomal protein L11/L12; Region: RL11; smart00649 446468014009 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 446468014010 putative thiostrepton binding site; other site 446468014011 23S rRNA interface [nucleotide binding]; other site 446468014012 L7/L12 interface [polypeptide binding]; other site 446468014013 L25 interface [polypeptide binding]; other site 446468014014 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 446468014015 mRNA/rRNA interface [nucleotide binding]; other site 446468014016 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 446468014017 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 446468014018 23S rRNA interface [nucleotide binding]; other site 446468014019 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 446468014020 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 446468014021 core dimer interface [polypeptide binding]; other site 446468014022 peripheral dimer interface [polypeptide binding]; other site 446468014023 L10 interface [polypeptide binding]; other site 446468014024 L11 interface [polypeptide binding]; other site 446468014025 putative EF-Tu interaction site [polypeptide binding]; other site 446468014026 putative EF-G interaction site [polypeptide binding]; other site 446468014027 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 446468014028 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 446468014029 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 446468014030 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 446468014031 RPB1 interaction site [polypeptide binding]; other site 446468014032 RPB10 interaction site [polypeptide binding]; other site 446468014033 RPB11 interaction site [polypeptide binding]; other site 446468014034 RPB3 interaction site [polypeptide binding]; other site 446468014035 RPB12 interaction site [polypeptide binding]; other site 446468014036 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446468014037 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 446468014038 S17 interaction site [polypeptide binding]; other site 446468014039 S8 interaction site; other site 446468014040 16S rRNA interaction site [nucleotide binding]; other site 446468014041 streptomycin interaction site [chemical binding]; other site 446468014042 23S rRNA interaction site [nucleotide binding]; other site 446468014043 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 446468014044 30S ribosomal protein S7; Validated; Region: PRK05302 446468014045 elongation factor G; Reviewed; Region: PRK00007 446468014046 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 446468014047 G1 box; other site 446468014048 putative GEF interaction site [polypeptide binding]; other site 446468014049 GTP/Mg2+ binding site [chemical binding]; other site 446468014050 Switch I region; other site 446468014051 G2 box; other site 446468014052 G3 box; other site 446468014053 Switch II region; other site 446468014054 G4 box; other site 446468014055 G5 box; other site 446468014056 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 446468014057 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 446468014058 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 446468014059 elongation factor Tu; Reviewed; Region: PRK00049 446468014060 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 446468014061 G1 box; other site 446468014062 GEF interaction site [polypeptide binding]; other site 446468014063 GTP/Mg2+ binding site [chemical binding]; other site 446468014064 Switch I region; other site 446468014065 G2 box; other site 446468014066 G3 box; other site 446468014067 Switch II region; other site 446468014068 G4 box; other site 446468014069 G5 box; other site 446468014070 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 446468014071 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 446468014072 Antibiotic Binding Site [chemical binding]; other site 446468014073 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 446468014074 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 446468014075 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 446468014076 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 446468014077 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 446468014078 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 446468014079 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 446468014080 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 446468014081 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 446468014082 putative translocon binding site; other site 446468014083 protein-rRNA interface [nucleotide binding]; other site 446468014084 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 446468014085 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 446468014086 G-X-X-G motif; other site 446468014087 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 446468014088 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 446468014089 23S rRNA interface [nucleotide binding]; other site 446468014090 5S rRNA interface [nucleotide binding]; other site 446468014091 putative antibiotic binding site [chemical binding]; other site 446468014092 L25 interface [polypeptide binding]; other site 446468014093 L27 interface [polypeptide binding]; other site 446468014094 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 446468014095 putative translocon interaction site; other site 446468014096 23S rRNA interface [nucleotide binding]; other site 446468014097 signal recognition particle (SRP54) interaction site; other site 446468014098 L23 interface [polypeptide binding]; other site 446468014099 trigger factor interaction site; other site 446468014100 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 446468014101 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 446468014102 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 446468014103 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 446468014104 RNA binding site [nucleotide binding]; other site 446468014105 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 446468014106 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 446468014107 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 446468014108 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 446468014109 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 446468014110 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 446468014111 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446468014112 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 446468014113 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 446468014114 5S rRNA interface [nucleotide binding]; other site 446468014115 L27 interface [polypeptide binding]; other site 446468014116 23S rRNA interface [nucleotide binding]; other site 446468014117 L5 interface [polypeptide binding]; other site 446468014118 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 446468014119 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 446468014120 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 446468014121 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 446468014122 23S rRNA binding site [nucleotide binding]; other site 446468014123 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 446468014124 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 446468014125 SecY translocase; Region: SecY; pfam00344 446468014126 adenylate kinase; Reviewed; Region: adk; PRK00279 446468014127 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 446468014128 AMP-binding site [chemical binding]; other site 446468014129 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 446468014130 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 446468014131 active site 446468014132 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468014133 2TM domain; Region: 2TM; pfam13239 446468014134 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 446468014135 rRNA binding site [nucleotide binding]; other site 446468014136 predicted 30S ribosome binding site; other site 446468014137 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 446468014138 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 446468014139 30S ribosomal protein S13; Region: bact_S13; TIGR03631 446468014140 30S ribosomal protein S11; Validated; Region: PRK05309 446468014141 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 446468014142 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 446468014143 alphaNTD homodimer interface [polypeptide binding]; other site 446468014144 alphaNTD - beta interaction site [polypeptide binding]; other site 446468014145 alphaNTD - beta' interaction site [polypeptide binding]; other site 446468014146 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 446468014147 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 446468014148 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 446468014149 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 446468014150 dimerization interface 3.5A [polypeptide binding]; other site 446468014151 active site 446468014152 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 446468014153 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 446468014154 nudix motif; other site 446468014155 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 446468014156 23S rRNA interface [nucleotide binding]; other site 446468014157 L3 interface [polypeptide binding]; other site 446468014158 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 446468014159 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 446468014160 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 446468014161 active site 446468014162 substrate binding site [chemical binding]; other site 446468014163 metal binding site [ion binding]; metal-binding site 446468014164 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 446468014165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468014166 nucleotide binding site [chemical binding]; other site 446468014167 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 446468014168 putative active site [active] 446468014169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468014170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 446468014171 NAD(P) binding site [chemical binding]; other site 446468014172 active site 446468014173 enoyl-CoA hydratase; Provisional; Region: PRK08252 446468014174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 446468014175 substrate binding site [chemical binding]; other site 446468014176 oxyanion hole (OAH) forming residues; other site 446468014177 trimer interface [polypeptide binding]; other site 446468014178 putative glycosyl transferase; Provisional; Region: PRK10073 446468014179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 446468014180 active site 446468014181 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 446468014182 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 446468014183 UDP-glucose 4-epimerase; Region: PLN02240 446468014184 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 446468014185 NAD binding site [chemical binding]; other site 446468014186 homodimer interface [polypeptide binding]; other site 446468014187 active site 446468014188 substrate binding site [chemical binding]; other site 446468014189 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 446468014190 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 446468014191 Na binding site [ion binding]; other site 446468014192 putative substrate binding site [chemical binding]; other site 446468014193 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 446468014194 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 446468014195 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 446468014196 phenylhydantoinase; Validated; Region: PRK08323 446468014197 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 446468014198 tetramer interface [polypeptide binding]; other site 446468014199 active site 446468014200 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 446468014201 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 446468014202 active site 446468014203 catalytic triad [active] 446468014204 dimer interface [polypeptide binding]; other site 446468014205 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 446468014206 spermidine synthase; Provisional; Region: PRK03612 446468014207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014208 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 446468014209 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 446468014210 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 446468014211 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 446468014212 active site residue [active] 446468014213 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 446468014214 active site residue [active] 446468014215 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 446468014216 Excalibur calcium-binding domain; Region: Excalibur; smart00894 446468014217 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 446468014218 amidase catalytic site [active] 446468014219 Zn binding residues [ion binding]; other site 446468014220 substrate binding site [chemical binding]; other site 446468014221 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 446468014222 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 446468014223 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 446468014224 putative substrate binding site [chemical binding]; other site 446468014225 putative ATP binding site [chemical binding]; other site 446468014226 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468014227 nudix motif; other site 446468014228 Phospholipid methyltransferase; Region: PEMT; cl17370 446468014229 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 446468014230 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 446468014231 molybdopterin cofactor binding site; other site 446468014232 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 446468014233 molybdopterin cofactor binding site; other site 446468014234 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 446468014235 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468014236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014237 active site 446468014238 phosphorylation site [posttranslational modification] 446468014239 intermolecular recognition site; other site 446468014240 dimerization interface [polypeptide binding]; other site 446468014241 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468014242 DNA binding site [nucleotide binding] 446468014243 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 446468014244 HAMP domain; Region: HAMP; pfam00672 446468014245 dimerization interface [polypeptide binding]; other site 446468014246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468014247 dimer interface [polypeptide binding]; other site 446468014248 phosphorylation site [posttranslational modification] 446468014249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468014250 ATP binding site [chemical binding]; other site 446468014251 Mg2+ binding site [ion binding]; other site 446468014252 G-X-G motif; other site 446468014253 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 446468014254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468014255 putative ADP-binding pocket [chemical binding]; other site 446468014256 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468014257 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 446468014258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468014259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014260 active site 446468014261 phosphorylation site [posttranslational modification] 446468014262 intermolecular recognition site; other site 446468014263 dimerization interface [polypeptide binding]; other site 446468014264 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468014265 DNA binding residues [nucleotide binding] 446468014266 dimerization interface [polypeptide binding]; other site 446468014267 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014268 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446468014269 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 446468014270 GAF domain; Region: GAF_3; pfam13492 446468014271 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 446468014272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 446468014273 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446468014274 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446468014275 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014276 dimerization interface [polypeptide binding]; other site 446468014277 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014278 dimerization interface [polypeptide binding]; other site 446468014279 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014280 dimerization interface [polypeptide binding]; other site 446468014281 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 446468014282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014283 dimerization interface [polypeptide binding]; other site 446468014284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014285 dimerization interface [polypeptide binding]; other site 446468014286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 446468014287 dimerization interface [polypeptide binding]; other site 446468014288 GAF domain; Region: GAF_2; pfam13185 446468014289 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 446468014290 Protein of unknown function (DUF904); Region: DUF904; pfam06005 446468014291 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 446468014292 dimer interface [polypeptide binding]; other site 446468014293 phosphorylation site [posttranslational modification] 446468014294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468014295 ATP binding site [chemical binding]; other site 446468014296 Mg2+ binding site [ion binding]; other site 446468014297 G-X-G motif; other site 446468014298 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 446468014299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014300 active site 446468014301 phosphorylation site [posttranslational modification] 446468014302 intermolecular recognition site; other site 446468014303 dimerization interface [polypeptide binding]; other site 446468014304 Response regulator receiver domain; Region: Response_reg; pfam00072 446468014305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014306 active site 446468014307 phosphorylation site [posttranslational modification] 446468014308 intermolecular recognition site; other site 446468014309 dimerization interface [polypeptide binding]; other site 446468014310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 446468014311 ANTAR domain; Region: ANTAR; pfam03861 446468014312 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468014313 anti sigma factor interaction site; other site 446468014314 regulatory phosphorylation site [posttranslational modification]; other site 446468014315 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 446468014317 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 446468014318 putative ADP-binding pocket [chemical binding]; other site 446468014319 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446468014320 active site 446468014321 CopC domain; Region: CopC; pfam04234 446468014322 Transcription factor WhiB; Region: Whib; pfam02467 446468014323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468014324 Coenzyme A binding pocket [chemical binding]; other site 446468014325 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 446468014326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 446468014327 inhibitor-cofactor binding pocket; inhibition site 446468014328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 446468014329 catalytic residue [active] 446468014330 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 446468014331 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 446468014332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 446468014333 substrate binding pocket [chemical binding]; other site 446468014334 membrane-bound complex binding site; other site 446468014335 hinge residues; other site 446468014336 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 446468014337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014338 dimer interface [polypeptide binding]; other site 446468014339 conserved gate region; other site 446468014340 putative PBP binding loops; other site 446468014341 ABC-ATPase subunit interface; other site 446468014342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014343 dimer interface [polypeptide binding]; other site 446468014344 conserved gate region; other site 446468014345 putative PBP binding loops; other site 446468014346 ABC-ATPase subunit interface; other site 446468014347 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 446468014348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468014349 Walker A/P-loop; other site 446468014350 ATP binding site [chemical binding]; other site 446468014351 Q-loop/lid; other site 446468014352 ABC transporter signature motif; other site 446468014353 Walker B; other site 446468014354 D-loop; other site 446468014355 H-loop/switch region; other site 446468014356 CAAX protease self-immunity; Region: Abi; pfam02517 446468014357 polyphosphate kinase; Provisional; Region: PRK05443 446468014358 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 446468014359 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 446468014360 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 446468014361 putative domain interface [polypeptide binding]; other site 446468014362 putative active site [active] 446468014363 catalytic site [active] 446468014364 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 446468014365 putative domain interface [polypeptide binding]; other site 446468014366 putative active site [active] 446468014367 catalytic site [active] 446468014368 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 446468014369 active site 446468014370 Ap6A binding site [chemical binding]; other site 446468014371 nudix motif; other site 446468014372 metal binding site [ion binding]; metal-binding site 446468014373 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 446468014374 catalytic core [active] 446468014375 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 446468014376 putative hydrophobic ligand binding site [chemical binding]; other site 446468014377 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 446468014378 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468014379 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446468014380 anti sigma factor interaction site; other site 446468014381 regulatory phosphorylation site [posttranslational modification]; other site 446468014382 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 446468014383 CoA-transferase family III; Region: CoA_transf_3; pfam02515 446468014384 G5 domain; Region: G5; pfam07501 446468014385 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 446468014386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014387 S-adenosylmethionine binding site [chemical binding]; other site 446468014388 PspC domain; Region: PspC; pfam04024 446468014389 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446468014390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468014391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468014392 ATP binding site [chemical binding]; other site 446468014393 Mg2+ binding site [ion binding]; other site 446468014394 G-X-G motif; other site 446468014395 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 446468014396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014397 active site 446468014398 phosphorylation site [posttranslational modification] 446468014399 intermolecular recognition site; other site 446468014400 dimerization interface [polypeptide binding]; other site 446468014401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 446468014402 DNA binding residues [nucleotide binding] 446468014403 dimerization interface [polypeptide binding]; other site 446468014404 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 446468014405 active site 446468014406 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 446468014407 Part of AAA domain; Region: AAA_19; pfam13245 446468014408 Family description; Region: UvrD_C_2; pfam13538 446468014409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468014410 sequence-specific DNA binding site [nucleotide binding]; other site 446468014411 salt bridge; other site 446468014412 Transcription factor WhiB; Region: Whib; pfam02467 446468014413 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468014414 Tic20-like protein; Region: Tic20; pfam09685 446468014415 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 446468014416 active site 446468014417 Rhomboid family; Region: Rhomboid; pfam01694 446468014418 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 446468014419 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468014420 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468014421 active site 446468014422 ATP binding site [chemical binding]; other site 446468014423 substrate binding site [chemical binding]; other site 446468014424 activation loop (A-loop); other site 446468014425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 446468014426 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468014427 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468014428 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468014429 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468014430 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468014431 active site 446468014432 ATP binding site [chemical binding]; other site 446468014433 substrate binding site [chemical binding]; other site 446468014434 activation loop (A-loop); other site 446468014435 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 446468014436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 446468014437 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 446468014438 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 446468014439 Protein phosphatase 2C; Region: PP2C; pfam00481 446468014440 active site 446468014441 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446468014442 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446468014443 phosphopeptide binding site; other site 446468014444 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 446468014445 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 446468014446 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 446468014447 phosphopeptide binding site; other site 446468014448 Cupin domain; Region: Cupin_2; pfam07883 446468014449 Methane oxygenase PmoA; Region: PmoA; pfam14100 446468014450 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 446468014451 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 446468014452 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 446468014453 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468014454 Walker A/P-loop; other site 446468014455 ATP binding site [chemical binding]; other site 446468014456 Q-loop/lid; other site 446468014457 ABC transporter signature motif; other site 446468014458 Walker B; other site 446468014459 D-loop; other site 446468014460 H-loop/switch region; other site 446468014461 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 446468014462 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 446468014463 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 446468014464 Walker A/P-loop; other site 446468014465 ATP binding site [chemical binding]; other site 446468014466 Q-loop/lid; other site 446468014467 ABC transporter signature motif; other site 446468014468 Walker B; other site 446468014469 D-loop; other site 446468014470 H-loop/switch region; other site 446468014471 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 446468014472 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 446468014473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014474 dimer interface [polypeptide binding]; other site 446468014475 conserved gate region; other site 446468014476 putative PBP binding loops; other site 446468014477 ABC-ATPase subunit interface; other site 446468014478 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 446468014479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014480 dimer interface [polypeptide binding]; other site 446468014481 conserved gate region; other site 446468014482 putative PBP binding loops; other site 446468014483 ABC-ATPase subunit interface; other site 446468014484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 446468014485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 446468014486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 446468014487 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 446468014488 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 446468014489 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446468014490 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 446468014491 Subtilisin inhibitor-like; Region: SSI; cl11594 446468014492 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 446468014493 active site residue [active] 446468014494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468014495 putative active site [active] 446468014496 heme pocket [chemical binding]; other site 446468014497 GAF domain; Region: GAF; pfam01590 446468014498 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 446468014499 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 446468014500 putative active site [active] 446468014501 heme pocket [chemical binding]; other site 446468014502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 446468014503 dimer interface [polypeptide binding]; other site 446468014504 phosphorylation site [posttranslational modification] 446468014505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468014506 ATP binding site [chemical binding]; other site 446468014507 Mg2+ binding site [ion binding]; other site 446468014508 G-X-G motif; other site 446468014509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014510 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468014511 anti sigma factor interaction site; other site 446468014512 regulatory phosphorylation site [posttranslational modification]; other site 446468014513 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 446468014514 active site 446468014515 prephenate dehydratase; Provisional; Region: PRK11898 446468014516 Prephenate dehydratase; Region: PDT; pfam00800 446468014517 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 446468014518 putative L-Phe binding site [chemical binding]; other site 446468014519 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 446468014520 seryl-tRNA synthetase; Provisional; Region: PRK05431 446468014521 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 446468014522 dimer interface [polypeptide binding]; other site 446468014523 active site 446468014524 motif 1; other site 446468014525 motif 2; other site 446468014526 motif 3; other site 446468014527 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 446468014528 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 446468014529 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 446468014530 NAD(P) binding site [chemical binding]; other site 446468014531 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 446468014532 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468014533 Ligand Binding Site [chemical binding]; other site 446468014534 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 446468014535 Ligand Binding Site [chemical binding]; other site 446468014536 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446468014537 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446468014538 active site 446468014539 Protein of unknown function DUF262; Region: DUF262; pfam03235 446468014540 Uncharacterized conserved protein [Function unknown]; Region: COG1479 446468014541 Flavoprotein; Region: Flavoprotein; pfam02441 446468014542 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 446468014543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 446468014544 DNA-binding site [nucleotide binding]; DNA binding site 446468014545 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 446468014546 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468014547 Helix-turn-helix domain; Region: HTH_17; pfam12728 446468014548 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 446468014549 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 446468014550 active site 446468014551 DNA binding site [nucleotide binding] 446468014552 Int/Topo IB signature motif; other site 446468014553 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 446468014554 CoenzymeA binding site [chemical binding]; other site 446468014555 subunit interaction site [polypeptide binding]; other site 446468014556 PHB binding site; other site 446468014557 DNA polymerase III subunit beta; Validated; Region: PRK07761 446468014558 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 446468014559 putative DNA binding surface [nucleotide binding]; other site 446468014560 dimer interface [polypeptide binding]; other site 446468014561 beta-clamp/clamp loader binding surface; other site 446468014562 beta-clamp/translesion DNA polymerase binding surface; other site 446468014563 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 446468014564 Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681 446468014565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 446468014566 nudix motif; other site 446468014567 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 446468014568 DNA binding site [nucleotide binding] 446468014569 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 446468014570 NB-ARC domain; Region: NB-ARC; pfam00931 446468014571 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 446468014572 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 446468014573 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468014574 TPR motif; other site 446468014575 binding surface 446468014576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468014577 binding surface 446468014578 TPR motif; other site 446468014579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 446468014580 TPR motif; other site 446468014581 binding surface 446468014582 TPR repeat; Region: TPR_11; pfam13414 446468014583 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 446468014584 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 446468014585 Chitin binding domain; Region: Chitin_bind_3; pfam03067 446468014586 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468014587 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468014588 phosphodiesterase YaeI; Provisional; Region: PRK11340 446468014589 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 446468014590 putative active site [active] 446468014591 putative metal binding site [ion binding]; other site 446468014592 Yqey-like protein; Region: YqeY; pfam09424 446468014593 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 446468014594 Transglycosylase; Region: Transgly; pfam00912 446468014595 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 446468014596 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 446468014597 Transcription factor WhiB; Region: Whib; pfam02467 446468014598 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 446468014599 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446468014600 DTAP/Switch II; other site 446468014601 Switch I; other site 446468014602 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 446468014603 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 446468014604 DTAP/Switch II; other site 446468014605 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 446468014606 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 446468014607 homotrimer interaction site [polypeptide binding]; other site 446468014608 putative active site [active] 446468014609 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 446468014610 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 446468014611 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 446468014612 ligand binding site [chemical binding]; other site 446468014613 flexible hinge region; other site 446468014614 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 446468014615 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 446468014616 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 446468014617 minor groove reading motif; other site 446468014618 helix-hairpin-helix signature motif; other site 446468014619 substrate binding pocket [chemical binding]; other site 446468014620 active site 446468014621 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 446468014622 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 446468014623 putative active site [active] 446468014624 putative CoA binding site [chemical binding]; other site 446468014625 nudix motif; other site 446468014626 metal binding site [ion binding]; metal-binding site 446468014627 Colicin V production protein; Region: Colicin_V; pfam02674 446468014628 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 446468014629 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 446468014630 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 446468014631 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014632 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468014633 anti sigma factor interaction site; other site 446468014634 regulatory phosphorylation site [posttranslational modification]; other site 446468014635 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 446468014636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 446468014637 ATP binding site [chemical binding]; other site 446468014638 putative Mg++ binding site [ion binding]; other site 446468014639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 446468014640 nucleotide binding region [chemical binding]; other site 446468014641 ATP-binding site [chemical binding]; other site 446468014642 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 446468014643 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 446468014644 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 446468014645 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 446468014646 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 446468014647 ATP binding site [chemical binding]; other site 446468014648 Walker A motif; other site 446468014649 hexamer interface [polypeptide binding]; other site 446468014650 Walker B motif; other site 446468014651 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 446468014652 Fic family protein [Function unknown]; Region: COG3177 446468014653 acetyl-CoA synthetase; Provisional; Region: PRK00174 446468014654 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 446468014655 active site 446468014656 CoA binding site [chemical binding]; other site 446468014657 acyl-activating enzyme (AAE) consensus motif; other site 446468014658 AMP binding site [chemical binding]; other site 446468014659 acetate binding site [chemical binding]; other site 446468014660 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 446468014661 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 446468014662 Domain of unknown function (DUF309); Region: DUF309; pfam03745 446468014663 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 446468014664 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 446468014665 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 446468014666 catalytic core [active] 446468014667 ACT domain; Region: ACT_6; pfam13740 446468014668 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 446468014669 phosphoserine phosphatase SerB; Region: serB; TIGR00338 446468014670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 446468014671 motif II; other site 446468014672 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468014673 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 446468014674 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468014675 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468014676 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 446468014677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468014678 Walker A/P-loop; other site 446468014679 ATP binding site [chemical binding]; other site 446468014680 Q-loop/lid; other site 446468014681 ABC transporter signature motif; other site 446468014682 Walker B; other site 446468014683 D-loop; other site 446468014684 H-loop/switch region; other site 446468014685 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 446468014686 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 446468014687 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 446468014688 hypothetical protein; Provisional; Region: PRK10621 446468014689 HD domain; Region: HD_3; pfam13023 446468014690 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 446468014691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468014692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468014693 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 446468014694 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 446468014695 dimer interface [polypeptide binding]; other site 446468014696 NADP binding site [chemical binding]; other site 446468014697 catalytic residues [active] 446468014698 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 446468014699 adenosine deaminase; Provisional; Region: PRK09358 446468014700 active site 446468014701 Small secreted domain (DUF320); Region: DUF320; pfam03777 446468014702 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446468014703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014704 S-adenosylmethionine binding site [chemical binding]; other site 446468014705 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 446468014706 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 446468014707 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468014708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468014709 Coenzyme A binding pocket [chemical binding]; other site 446468014710 Smr domain; Region: Smr; pfam01713 446468014711 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446468014712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468014713 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 446468014714 acyl-CoA synthetase; Validated; Region: PRK08162 446468014715 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 446468014716 acyl-activating enzyme (AAE) consensus motif; other site 446468014717 putative active site [active] 446468014718 AMP binding site [chemical binding]; other site 446468014719 putative CoA binding site [chemical binding]; other site 446468014720 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 446468014721 active site 446468014722 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 446468014723 EamA-like transporter family; Region: EamA; pfam00892 446468014724 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 446468014725 H+ Antiporter protein; Region: 2A0121; TIGR00900 446468014726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468014727 Putative zinc-finger; Region: zf-HC2; pfam13490 446468014728 Anti-sigma-K factor rskA; Region: RskA; pfam10099 446468014729 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 446468014730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468014731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468014732 DNA binding residues [nucleotide binding] 446468014733 Fasciclin domain; Region: Fasciclin; pfam02469 446468014734 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 446468014735 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 446468014736 Moco binding site; other site 446468014737 metal coordination site [ion binding]; other site 446468014738 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 446468014739 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 446468014740 ligand binding site [chemical binding]; other site 446468014741 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 446468014742 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 446468014743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 446468014744 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 446468014745 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 446468014746 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 446468014747 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 446468014748 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468014749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468014750 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 446468014751 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 446468014752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468014753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 446468014754 active site 446468014755 phosphorylation site [posttranslational modification] 446468014756 intermolecular recognition site; other site 446468014757 dimerization interface [polypeptide binding]; other site 446468014758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468014759 DNA binding site [nucleotide binding] 446468014760 alanine racemase; Reviewed; Region: alr; PRK00053 446468014761 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 446468014762 active site 446468014763 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 446468014764 dimer interface [polypeptide binding]; other site 446468014765 substrate binding site [chemical binding]; other site 446468014766 catalytic residues [active] 446468014767 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 446468014768 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 446468014769 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468014770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014771 S-adenosylmethionine binding site [chemical binding]; other site 446468014772 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 446468014773 classical (c) SDRs; Region: SDR_c; cd05233 446468014774 NAD(P) binding site [chemical binding]; other site 446468014775 active site 446468014776 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 446468014777 homodimer interface [polypeptide binding]; other site 446468014778 putative metal binding site [ion binding]; other site 446468014779 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 446468014780 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 446468014781 HisG, C-terminal domain; Region: HisG_C; pfam08029 446468014782 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468014783 DNA binding residues [nucleotide binding] 446468014784 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 446468014785 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468014786 DNA binding residues [nucleotide binding] 446468014787 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 446468014788 DNA binding residues [nucleotide binding] 446468014789 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468014790 drug binding residues [chemical binding]; other site 446468014791 dimer interface [polypeptide binding]; other site 446468014792 Predicted membrane protein [Function unknown]; Region: COG4270 446468014793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014794 S-adenosylmethionine binding site [chemical binding]; other site 446468014795 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 446468014796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014797 dimer interface [polypeptide binding]; other site 446468014798 conserved gate region; other site 446468014799 putative PBP binding loops; other site 446468014800 ABC-ATPase subunit interface; other site 446468014801 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 446468014802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468014803 dimer interface [polypeptide binding]; other site 446468014804 conserved gate region; other site 446468014805 putative PBP binding loops; other site 446468014806 ABC-ATPase subunit interface; other site 446468014807 PBP superfamily domain; Region: PBP_like_2; cl17296 446468014808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 446468014809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 446468014810 phosphorylation site [posttranslational modification] 446468014811 intermolecular recognition site; other site 446468014812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 446468014813 DNA binding site [nucleotide binding] 446468014814 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 446468014815 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 446468014816 Walker A/P-loop; other site 446468014817 ATP binding site [chemical binding]; other site 446468014818 Q-loop/lid; other site 446468014819 ABC transporter signature motif; other site 446468014820 Walker B; other site 446468014821 D-loop; other site 446468014822 H-loop/switch region; other site 446468014823 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 446468014824 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 446468014825 catalytic residues [active] 446468014826 Domain of unknown function (DUF202); Region: DUF202; cl09954 446468014827 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 446468014828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468014829 NAD(P) binding site [chemical binding]; other site 446468014830 active site 446468014831 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 446468014832 WbqC-like protein family; Region: WbqC; pfam08889 446468014833 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 446468014834 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 446468014835 DXD motif; other site 446468014836 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 446468014837 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 446468014838 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 446468014839 Protein of unknown function (DUF664); Region: DUF664; pfam04978 446468014840 DinB superfamily; Region: DinB_2; pfam12867 446468014841 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 446468014842 TAP-like protein; Region: Abhydrolase_4; pfam08386 446468014843 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 446468014844 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 446468014845 active site 446468014846 metal binding site [ion binding]; metal-binding site 446468014847 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 446468014848 intersubunit interface [polypeptide binding]; other site 446468014849 active site 446468014850 Zn2+ binding site [ion binding]; other site 446468014851 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 446468014852 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 446468014853 tetramerization interface [polypeptide binding]; other site 446468014854 NAD(P) binding site [chemical binding]; other site 446468014855 catalytic residues [active] 446468014856 choline dehydrogenase; Validated; Region: PRK02106 446468014857 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 446468014858 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 446468014859 putative catalytic site [active] 446468014860 putative metal binding site [ion binding]; other site 446468014861 putative phosphate binding site [ion binding]; other site 446468014862 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 446468014863 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 446468014864 dimerization interface [polypeptide binding]; other site 446468014865 ATP binding site [chemical binding]; other site 446468014866 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 446468014867 dimerization interface [polypeptide binding]; other site 446468014868 ATP binding site [chemical binding]; other site 446468014869 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 446468014870 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 446468014871 putative active site [active] 446468014872 catalytic triad [active] 446468014873 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 446468014875 Mg2+ binding site [ion binding]; other site 446468014876 G-X-G motif; other site 446468014877 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 446468014878 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 446468014879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468014880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 446468014881 DNA binding residues [nucleotide binding] 446468014882 CAAX protease self-immunity; Region: Abi; pfam02517 446468014883 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 446468014884 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 446468014885 TPP-binding site [chemical binding]; other site 446468014886 tetramer interface [polypeptide binding]; other site 446468014887 heterodimer interface [polypeptide binding]; other site 446468014888 phosphorylation loop region [posttranslational modification] 446468014889 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 446468014890 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 446468014891 alpha subunit interface [polypeptide binding]; other site 446468014892 TPP binding site [chemical binding]; other site 446468014893 heterodimer interface [polypeptide binding]; other site 446468014894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 446468014895 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 446468014896 E3 interaction surface; other site 446468014897 lipoyl attachment site [posttranslational modification]; other site 446468014898 e3 binding domain; Region: E3_binding; pfam02817 446468014899 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 446468014900 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 446468014901 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468014902 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468014903 Predicted permeases [General function prediction only]; Region: COG0679 446468014904 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468014905 active site 446468014906 ATP binding site [chemical binding]; other site 446468014907 substrate binding site [chemical binding]; other site 446468014908 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 446468014909 activation loop (A-loop); other site 446468014910 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 446468014911 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 446468014912 Proteins of 100 residues with WXG; Region: WXG100; cl02005 446468014913 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 446468014914 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468014915 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 446468014916 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468014917 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 446468014918 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 446468014919 FOG: WD40 repeat [General function prediction only]; Region: COG2319 446468014920 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 446468014921 structural tetrad; other site 446468014922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 446468014923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468014924 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 446468014925 oxidoreductase; Provisional; Region: PRK12743 446468014926 classical (c) SDRs; Region: SDR_c; cd05233 446468014927 NAD(P) binding site [chemical binding]; other site 446468014928 active site 446468014929 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 446468014930 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 446468014931 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 446468014932 FAD binding site [chemical binding]; other site 446468014933 substrate binding site [chemical binding]; other site 446468014934 catalytic residues [active] 446468014935 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 446468014936 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014937 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468014938 ATP binding site [chemical binding]; other site 446468014939 Mg2+ binding site [ion binding]; other site 446468014940 G-X-G motif; other site 446468014941 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 446468014942 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 446468014943 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 446468014944 catalytic residue [active] 446468014945 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468014946 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 446468014947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 446468014948 non-specific DNA binding site [nucleotide binding]; other site 446468014949 salt bridge; other site 446468014950 sequence-specific DNA binding site [nucleotide binding]; other site 446468014951 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 446468014952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 446468014953 Mg2+ binding site [ion binding]; other site 446468014954 G-X-G motif; other site 446468014955 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 446468014956 DNA binding residues [nucleotide binding] 446468014957 putative ATP-grasp target RiPP; Region: GRASP_targ; TIGR04186 446468014958 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 446468014959 ATP-grasp domain; Region: ATP-grasp_4; cl17255 446468014960 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468014961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014962 S-adenosylmethionine binding site [chemical binding]; other site 446468014963 Domain of unknown function (DUF397); Region: DUF397; pfam04149 446468014964 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 446468014965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468014966 S-adenosylmethionine binding site [chemical binding]; other site 446468014967 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468014968 Coenzyme A binding pocket [chemical binding]; other site 446468014969 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 446468014970 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 446468014971 ATPase involved in DNA repair; Region: DUF3686; pfam12458 446468014972 AAA domain; Region: AAA_22; pfam13401 446468014973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468014974 Walker A motif; other site 446468014975 ATP binding site [chemical binding]; other site 446468014976 Walker B motif; other site 446468014977 arginine finger; other site 446468014978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 446468014979 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 446468014980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 446468014981 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 446468014982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 446468014983 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 446468014984 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 446468014985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 446468014986 Walker A/P-loop; other site 446468014987 ATP binding site [chemical binding]; other site 446468014988 Q-loop/lid; other site 446468014989 ABC transporter signature motif; other site 446468014990 Walker B; other site 446468014991 D-loop; other site 446468014992 H-loop/switch region; other site 446468014993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 446468014994 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 446468014995 NAD(P) binding site [chemical binding]; other site 446468014996 active site 446468014997 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 446468014998 Clp amino terminal domain; Region: Clp_N; pfam02861 446468014999 Clp amino terminal domain; Region: Clp_N; pfam02861 446468015000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468015001 Walker A motif; other site 446468015002 ATP binding site [chemical binding]; other site 446468015003 Walker B motif; other site 446468015004 arginine finger; other site 446468015005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468015006 Walker A motif; other site 446468015007 ATP binding site [chemical binding]; other site 446468015008 Walker B motif; other site 446468015009 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 446468015010 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 446468015011 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 446468015012 DNA binding residues [nucleotide binding] 446468015013 putative dimer interface [polypeptide binding]; other site 446468015014 chaperone protein DnaJ; Provisional; Region: PRK14295 446468015015 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 446468015016 HSP70 interaction site [polypeptide binding]; other site 446468015017 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 446468015018 Zn binding sites [ion binding]; other site 446468015019 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 446468015020 dimer interface [polypeptide binding]; other site 446468015021 GrpE; Region: GrpE; pfam01025 446468015022 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 446468015023 dimer interface [polypeptide binding]; other site 446468015024 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 446468015025 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 446468015026 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 446468015027 nucleotide binding site [chemical binding]; other site 446468015028 NEF interaction site [polypeptide binding]; other site 446468015029 SBD interface [polypeptide binding]; other site 446468015030 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 446468015031 4Fe-4S binding domain; Region: Fer4; cl02805 446468015032 4Fe-4S binding domain; Region: Fer4; pfam00037 446468015033 Cysteine-rich domain; Region: CCG; pfam02754 446468015034 Cysteine-rich domain; Region: CCG; pfam02754 446468015035 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 446468015036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468015037 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 446468015038 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 446468015039 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 446468015040 Walker A/P-loop; other site 446468015041 ATP binding site [chemical binding]; other site 446468015042 Q-loop/lid; other site 446468015043 ABC transporter signature motif; other site 446468015044 Walker B; other site 446468015045 D-loop; other site 446468015046 H-loop/switch region; other site 446468015047 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 446468015048 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468015049 Histidine kinase; Region: HisKA_3; pfam07730 446468015050 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 446468015051 Histidine kinase; Region: HisKA_3; pfam07730 446468015052 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 446468015053 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 446468015054 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 446468015055 trimer interface [polypeptide binding]; other site 446468015056 putative metal binding site [ion binding]; other site 446468015057 CHASE3 domain; Region: CHASE3; cl05000 446468015058 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 446468015059 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 446468015060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 446468015061 Coenzyme A binding pocket [chemical binding]; other site 446468015062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468015063 putative substrate translocation pore; other site 446468015064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 446468015065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 446468015066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 446468015067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468015068 S-adenosylmethionine binding site [chemical binding]; other site 446468015069 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 446468015070 homotrimer interaction site [polypeptide binding]; other site 446468015071 putative active site [active] 446468015072 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 446468015073 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468015074 active site 446468015075 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 446468015076 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 446468015077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 446468015078 substrate binding site [chemical binding]; other site 446468015079 ATP binding site [chemical binding]; other site 446468015080 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 446468015081 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 446468015082 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 446468015083 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 446468015084 Uncharacterized conserved protein [Function unknown]; Region: COG1739 446468015085 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 446468015086 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 446468015087 PQQ-like domain; Region: PQQ_2; pfam13360 446468015088 Protein kinase domain; Region: Pkinase; pfam00069 446468015089 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468015090 active site 446468015091 ATP binding site [chemical binding]; other site 446468015092 substrate binding site [chemical binding]; other site 446468015093 activation loop (A-loop); other site 446468015094 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446468015095 Interdomain contacts; other site 446468015096 Cytokine receptor motif; other site 446468015097 RNB domain; Region: RNB; pfam00773 446468015098 NAD synthetase; Provisional; Region: PRK13981 446468015099 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 446468015100 multimer interface [polypeptide binding]; other site 446468015101 active site 446468015102 catalytic triad [active] 446468015103 protein interface 1 [polypeptide binding]; other site 446468015104 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 446468015105 Ligand Binding Site [chemical binding]; other site 446468015106 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 446468015107 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 446468015108 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 446468015109 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 446468015110 Walker A motif; other site 446468015111 ATP binding site [chemical binding]; other site 446468015112 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 446468015113 AAA-like domain; Region: AAA_10; pfam12846 446468015114 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 446468015115 NlpC/P60 family; Region: NLPC_P60; pfam00877 446468015116 MoxR-like ATPases [General function prediction only]; Region: COG0714 446468015117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 446468015118 Walker A motif; other site 446468015119 ATP binding site [chemical binding]; other site 446468015120 Walker B motif; other site 446468015121 arginine finger; other site 446468015122 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 446468015123 Protein of unknown function DUF58; Region: DUF58; pfam01882 446468015124 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 446468015125 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 446468015126 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468015127 active site 446468015128 ATP binding site [chemical binding]; other site 446468015129 substrate binding site [chemical binding]; other site 446468015130 activation loop (A-loop); other site 446468015131 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446468015132 Interdomain contacts; other site 446468015133 Cytokine receptor motif; other site 446468015134 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 446468015135 Interdomain contacts; other site 446468015136 Cytokine receptor motif; other site 446468015137 Protein kinase domain; Region: Pkinase; pfam00069 446468015138 Catalytic domain of Protein Kinases; Region: PKc; cd00180 446468015139 active site 446468015140 ATP binding site [chemical binding]; other site 446468015141 substrate binding site [chemical binding]; other site 446468015142 activation loop (A-loop); other site 446468015143 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 446468015144 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 446468015145 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 446468015146 heterodimer interface [polypeptide binding]; other site 446468015147 substrate interaction site [chemical binding]; other site 446468015148 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 446468015149 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 446468015150 active site 446468015151 substrate binding site [chemical binding]; other site 446468015152 coenzyme B12 binding site [chemical binding]; other site 446468015153 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 446468015154 B12 binding site [chemical binding]; other site 446468015155 cobalt ligand [ion binding]; other site 446468015156 membrane ATPase/protein kinase; Provisional; Region: PRK09435 446468015157 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 446468015158 Walker A; other site 446468015159 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 446468015160 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 446468015161 anti sigma factor interaction site; other site 446468015162 regulatory phosphorylation site [posttranslational modification]; other site 446468015163 Methyltransferase domain; Region: Methyltransf_23; pfam13489 446468015164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 446468015165 S-adenosylmethionine binding site [chemical binding]; other site 446468015166 phosphoenolpyruvate synthase; Validated; Region: PRK06241 446468015167 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 446468015168 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 446468015169 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 446468015170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 446468015171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 446468015172 DNA binding site [nucleotide binding] 446468015173 domain linker motif; other site 446468015174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 446468015175 dimerization interface [polypeptide binding]; other site 446468015176 ligand binding site [chemical binding]; other site 446468015177 Hemerythrin-like domain; Region: Hr-like; cd12108 446468015178 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 446468015179 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 446468015180 xylose isomerase; Provisional; Region: PRK12677 446468015181 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 446468015182 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 446468015183 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 446468015184 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 446468015185 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 446468015186 Asp-box motif; other site 446468015187 catalytic site [active] 446468015188 Cellulose binding domain; Region: CBM_2; pfam00553 446468015189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 446468015190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468015191 dimer interface [polypeptide binding]; other site 446468015192 conserved gate region; other site 446468015193 putative PBP binding loops; other site 446468015194 ABC-ATPase subunit interface; other site 446468015195 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 446468015196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 446468015197 dimer interface [polypeptide binding]; other site 446468015198 conserved gate region; other site 446468015199 ABC-ATPase subunit interface; other site 446468015200 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 446468015201 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 446468015202 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 446468015203 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 446468015204 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 446468015205 ligand binding site [chemical binding]; other site 446468015206 Beta-lactamase; Region: Beta-lactamase; pfam00144 446468015207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 446468015208 Predicted transcriptional regulators [Transcription]; Region: COG1695 446468015209 Transcriptional regulator PadR-like family; Region: PadR; cl17335 446468015210 MarR family; Region: MarR_2; pfam12802 446468015211 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 446468015212 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 446468015213 nucleotide binding site [chemical binding]; other site 446468015214 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 446468015215 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 446468015216 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 446468015217 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 446468015218 nudix motif; other site