-- dump date 20140619_165334 -- class Genbank::misc_feature -- table misc_feature_note -- id note 317936000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 317936000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 317936000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936000004 Walker A motif; other site 317936000005 ATP binding site [chemical binding]; other site 317936000006 Walker B motif; other site 317936000007 arginine finger; other site 317936000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 317936000009 DnaA box-binding interface [nucleotide binding]; other site 317936000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 317936000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 317936000012 putative DNA binding surface [nucleotide binding]; other site 317936000013 dimer interface [polypeptide binding]; other site 317936000014 beta-clamp/clamp loader binding surface; other site 317936000015 beta-clamp/translesion DNA polymerase binding surface; other site 317936000016 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 317936000017 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 317936000018 Walker A/P-loop; other site 317936000019 ATP binding site [chemical binding]; other site 317936000020 Q-loop/lid; other site 317936000021 ABC transporter signature motif; other site 317936000022 Walker B; other site 317936000023 D-loop; other site 317936000024 H-loop/switch region; other site 317936000025 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936000026 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936000027 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 317936000028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936000029 dimer interface [polypeptide binding]; other site 317936000030 conserved gate region; other site 317936000031 ABC-ATPase subunit interface; other site 317936000032 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 317936000033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936000034 dimer interface [polypeptide binding]; other site 317936000035 conserved gate region; other site 317936000036 putative PBP binding loops; other site 317936000037 ABC-ATPase subunit interface; other site 317936000038 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 317936000039 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936000040 substrate binding pocket [chemical binding]; other site 317936000041 membrane-bound complex binding site; other site 317936000042 hinge residues; other site 317936000043 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 317936000044 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 317936000045 SdiA-regulated; Region: SdiA-regulated; cd09971 317936000046 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 317936000047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936000048 FeS/SAM binding site; other site 317936000049 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936000050 anti sigma factor interaction site; other site 317936000051 regulatory phosphorylation site [posttranslational modification]; other site 317936000052 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 317936000053 Bacterial sugar transferase; Region: Bac_transf; pfam02397 317936000054 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936000055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936000056 active site 317936000057 KGK domain; Region: KGK; pfam08872 317936000058 KGK domain; Region: KGK; pfam08872 317936000059 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 317936000060 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 317936000061 G1 box; other site 317936000062 GTP/Mg2+ binding site [chemical binding]; other site 317936000063 G2 box; other site 317936000064 Switch I region; other site 317936000065 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 317936000066 G3 box; other site 317936000067 Switch II region; other site 317936000068 G4 box; other site 317936000069 Transposase; Region: HTH_Tnp_1; cl17663 317936000070 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 317936000071 ferredoxin-sulfite reductase; Region: sir; TIGR02042 317936000072 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 317936000073 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 317936000074 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 317936000075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 317936000076 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 317936000077 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 317936000078 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 317936000079 active site 317936000080 catalytic residues [active] 317936000081 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 317936000082 Low molecular weight phosphatase family; Region: LMWPc; cd00115 317936000083 active site 317936000084 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 317936000085 arsenical-resistance protein; Region: acr3; TIGR00832 317936000086 PBP superfamily domain; Region: PBP_like_2; cl17296 317936000087 YGGT family; Region: YGGT; pfam02325 317936000088 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936000089 active site 317936000090 carotene isomerase; Region: carot_isom; TIGR02730 317936000091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936000092 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 317936000093 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 317936000094 intersubunit interface [polypeptide binding]; other site 317936000095 ATP-grasp domain; Region: ATP-grasp; pfam02222 317936000096 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936000097 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936000098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936000099 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936000100 dimer interface [polypeptide binding]; other site 317936000101 phosphorylation site [posttranslational modification] 317936000102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000103 ATP binding site [chemical binding]; other site 317936000104 Mg2+ binding site [ion binding]; other site 317936000105 G-X-G motif; other site 317936000106 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 317936000107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936000108 Walker A/P-loop; other site 317936000109 ATP binding site [chemical binding]; other site 317936000110 Q-loop/lid; other site 317936000111 ABC transporter signature motif; other site 317936000112 Walker B; other site 317936000113 D-loop; other site 317936000114 H-loop/switch region; other site 317936000115 ABC transporter; Region: ABC_tran_2; pfam12848 317936000116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 317936000117 ABC transporter; Region: ABC_tran_2; pfam12848 317936000118 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 317936000119 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 317936000120 HflK protein; Region: hflK; TIGR01933 317936000121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936000122 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936000123 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936000124 Walker A/P-loop; other site 317936000125 ATP binding site [chemical binding]; other site 317936000126 Q-loop/lid; other site 317936000127 ABC transporter signature motif; other site 317936000128 Walker B; other site 317936000129 D-loop; other site 317936000130 H-loop/switch region; other site 317936000131 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936000132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936000133 active site 317936000134 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936000135 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 317936000136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936000137 active site 317936000138 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000139 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936000140 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 317936000141 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936000142 heat shock protein 90; Provisional; Region: PRK05218 317936000143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000144 ATP binding site [chemical binding]; other site 317936000145 Mg2+ binding site [ion binding]; other site 317936000146 G-X-G motif; other site 317936000147 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 317936000148 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 317936000149 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 317936000150 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 317936000151 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 317936000152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936000153 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936000154 active site 317936000155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936000156 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 317936000157 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 317936000158 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 317936000159 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936000160 putative metal binding site; other site 317936000161 Uncharacterized conserved protein [Function unknown]; Region: COG2928 317936000162 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 317936000163 putative RNA binding site [nucleotide binding]; other site 317936000164 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 317936000165 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 317936000166 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 317936000167 P loop; other site 317936000168 GTP binding site [chemical binding]; other site 317936000169 GAF domain; Region: GAF_3; pfam13492 317936000170 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 317936000171 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 317936000172 PsbP; Region: PsbP; pfam01789 317936000173 Maf-like protein; Region: Maf; pfam02545 317936000174 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 317936000175 active site 317936000176 dimer interface [polypeptide binding]; other site 317936000177 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 317936000178 amphipathic channel; other site 317936000179 Asn-Pro-Ala signature motifs; other site 317936000180 phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816 317936000181 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 317936000182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936000183 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936000184 DevC protein; Region: devC; TIGR01185 317936000185 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936000186 FtsX-like permease family; Region: FtsX; pfam02687 317936000187 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 317936000188 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936000189 Walker A/P-loop; other site 317936000190 ATP binding site [chemical binding]; other site 317936000191 Q-loop/lid; other site 317936000192 ABC transporter signature motif; other site 317936000193 Walker B; other site 317936000194 D-loop; other site 317936000195 H-loop/switch region; other site 317936000196 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 317936000197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936000198 active site 317936000199 motif I; other site 317936000200 motif II; other site 317936000201 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936000202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936000203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936000204 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936000205 Cytochrome P450; Region: p450; cl12078 317936000206 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 317936000207 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 317936000208 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936000209 ketol-acid reductoisomerase; Provisional; Region: PRK05479 317936000210 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 317936000211 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 317936000212 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 317936000213 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 317936000214 NADPH bind site [chemical binding]; other site 317936000215 putative FMN binding site [chemical binding]; other site 317936000216 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 317936000217 putative FMN binding site [chemical binding]; other site 317936000218 NADPH bind site [chemical binding]; other site 317936000219 PAS domain S-box; Region: sensory_box; TIGR00229 317936000220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000221 putative active site [active] 317936000222 heme pocket [chemical binding]; other site 317936000223 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936000224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000225 putative active site [active] 317936000226 heme pocket [chemical binding]; other site 317936000227 PAS domain; Region: PAS_8; pfam13188 317936000228 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936000229 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936000230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 317936000231 Histidine kinase; Region: HisKA_2; pfam07568 317936000232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000233 ATP binding site [chemical binding]; other site 317936000234 Mg2+ binding site [ion binding]; other site 317936000235 G-X-G motif; other site 317936000236 Response regulator receiver domain; Region: Response_reg; pfam00072 317936000237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936000238 active site 317936000239 phosphorylation site [posttranslational modification] 317936000240 intermolecular recognition site; other site 317936000241 dimerization interface [polypeptide binding]; other site 317936000242 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936000243 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000244 putative active site [active] 317936000245 heme pocket [chemical binding]; other site 317936000246 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936000247 dimer interface [polypeptide binding]; other site 317936000248 phosphorylation site [posttranslational modification] 317936000249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000250 ATP binding site [chemical binding]; other site 317936000251 Mg2+ binding site [ion binding]; other site 317936000252 G-X-G motif; other site 317936000253 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936000254 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936000255 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936000256 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936000257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936000258 metal binding site [ion binding]; metal-binding site 317936000259 active site 317936000260 I-site; other site 317936000261 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 317936000262 putative catalytic site [active] 317936000263 putative phosphate binding site [ion binding]; other site 317936000264 active site 317936000265 metal binding site A [ion binding]; metal-binding site 317936000266 DNA binding site [nucleotide binding] 317936000267 putative AP binding site [nucleotide binding]; other site 317936000268 putative metal binding site B [ion binding]; other site 317936000269 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000270 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 317936000271 putative ADP-binding pocket [chemical binding]; other site 317936000272 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 317936000273 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 317936000274 NAD(P) binding site [chemical binding]; other site 317936000275 Predicted flavoprotein [General function prediction only]; Region: COG0431 317936000276 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 317936000277 ferrochelatase; Reviewed; Region: hemH; PRK00035 317936000278 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 317936000279 active site 317936000280 C-terminal domain interface [polypeptide binding]; other site 317936000281 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 317936000282 active site 317936000283 N-terminal domain interface [polypeptide binding]; other site 317936000284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936000285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936000286 S-adenosylmethionine binding site [chemical binding]; other site 317936000287 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 317936000288 Flavoprotein; Region: Flavoprotein; pfam02441 317936000289 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 317936000290 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 317936000291 Predicted esterase [General function prediction only]; Region: COG0400 317936000292 putative hydrolase; Provisional; Region: PRK11460 317936000293 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 317936000294 Right handed beta helix region; Region: Beta_helix; pfam13229 317936000295 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 317936000296 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 317936000297 ligand binding site [chemical binding]; other site 317936000298 conserved repeat domain; Region: B_ant_repeat; TIGR01451 317936000299 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936000300 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936000301 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936000302 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936000303 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936000304 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 317936000305 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 317936000306 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 317936000307 inhibitor-cofactor binding pocket; inhibition site 317936000308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936000309 catalytic residue [active] 317936000310 MltA specific insert domain; Region: MltA; cl08398 317936000311 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936000312 Ligand Binding Site [chemical binding]; other site 317936000313 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 317936000314 Phosphoglycerate kinase; Region: PGK; pfam00162 317936000315 substrate binding site [chemical binding]; other site 317936000316 hinge regions; other site 317936000317 ADP binding site [chemical binding]; other site 317936000318 catalytic site [active] 317936000319 Cna protein B-type domain; Region: Cna_B; pfam05738 317936000320 Lamin Tail Domain; Region: LTD; pfam00932 317936000321 Domain of unknown function DUF11; Region: DUF11; pfam01345 317936000322 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 317936000323 conserved repeat domain; Region: B_ant_repeat; TIGR01451 317936000324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719 317936000325 threonine synthase; Validated; Region: PRK07591 317936000326 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 317936000327 homodimer interface [polypeptide binding]; other site 317936000328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936000329 catalytic residue [active] 317936000330 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 317936000331 MoaE interaction surface [polypeptide binding]; other site 317936000332 MoeB interaction surface [polypeptide binding]; other site 317936000333 thiocarboxylated glycine; other site 317936000334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000335 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 317936000336 Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909 317936000337 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 317936000338 active site 317936000339 Zn binding site [ion binding]; other site 317936000340 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 317936000341 substrate binding site [chemical binding]; other site 317936000342 active site 317936000343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936000344 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 317936000345 NAD(P) binding site [chemical binding]; other site 317936000346 active site 317936000347 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000348 putative active site [active] 317936000349 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 317936000350 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 317936000351 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 317936000352 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000353 putative active site [active] 317936000354 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936000355 putative cation:proton antiport protein; Provisional; Region: PRK10669 317936000356 TrkA-N domain; Region: TrkA_N; pfam02254 317936000357 TrkA-C domain; Region: TrkA_C; pfam02080 317936000358 TrkA-C domain; Region: TrkA_C; pfam02080 317936000359 bacterial Hfq-like; Region: Hfq; cd01716 317936000360 hexamer interface [polypeptide binding]; other site 317936000361 Sm1 motif; other site 317936000362 RNA binding site [nucleotide binding]; other site 317936000363 Sm2 motif; other site 317936000364 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 317936000365 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 317936000366 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 317936000367 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 317936000368 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 317936000369 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 317936000370 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 317936000371 RNA binding site [nucleotide binding]; other site 317936000372 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936000373 Chain length determinant protein; Region: Wzz; pfam02706 317936000374 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 317936000375 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936000376 Magnesium ion binding site [ion binding]; other site 317936000377 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000378 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 317936000379 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 317936000380 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 317936000381 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 317936000382 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 317936000383 Walker A/P-loop; other site 317936000384 ATP binding site [chemical binding]; other site 317936000385 Q-loop/lid; other site 317936000386 ABC transporter signature motif; other site 317936000387 Walker B; other site 317936000388 D-loop; other site 317936000389 H-loop/switch region; other site 317936000390 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 317936000391 putative carbohydrate binding site [chemical binding]; other site 317936000392 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 317936000393 putative trimer interface [polypeptide binding]; other site 317936000394 putative active site [active] 317936000395 putative substrate binding site [chemical binding]; other site 317936000396 putative CoA binding site [chemical binding]; other site 317936000397 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936000398 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936000399 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 317936000400 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936000401 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936000402 inhibitor-cofactor binding pocket; inhibition site 317936000403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936000404 catalytic residue [active] 317936000405 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 317936000406 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 317936000407 trimer interface [polypeptide binding]; other site 317936000408 active site 317936000409 substrate binding site [chemical binding]; other site 317936000410 CoA binding site [chemical binding]; other site 317936000411 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936000412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936000413 NAD(P) binding site [chemical binding]; other site 317936000414 active site 317936000415 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936000416 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936000417 inhibitor-cofactor binding pocket; inhibition site 317936000418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936000419 catalytic residue [active] 317936000420 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 317936000421 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 317936000422 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 317936000423 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 317936000424 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 317936000425 Ligand binding site; other site 317936000426 metal-binding site 317936000427 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 317936000428 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 317936000429 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 317936000430 trimer interface [polypeptide binding]; other site 317936000431 active site 317936000432 substrate binding site [chemical binding]; other site 317936000433 CoA binding site [chemical binding]; other site 317936000434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936000435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936000436 active site 317936000437 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936000438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936000439 active site 317936000440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936000441 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000442 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 317936000443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000444 putative ADP-binding pocket [chemical binding]; other site 317936000445 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936000446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000447 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936000448 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000449 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 317936000450 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 317936000451 active site 317936000452 dimer interface [polypeptide binding]; other site 317936000453 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 317936000454 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936000455 Ligand Binding Site [chemical binding]; other site 317936000456 Molecular Tunnel; other site 317936000457 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000458 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 317936000459 putative ADP-binding pocket [chemical binding]; other site 317936000460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936000461 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936000462 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936000463 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 317936000464 putative metal binding site; other site 317936000465 glutathione reductase; Validated; Region: PRK06116 317936000466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 317936000467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936000468 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 317936000469 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 317936000470 catalytic triad [active] 317936000471 dimer interface [polypeptide binding]; other site 317936000472 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 317936000473 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 317936000474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298 317936000475 Uncharacterized conserved protein [Function unknown]; Region: COG4715 317936000476 SWIM zinc finger; Region: SWIM; pfam04434 317936000477 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 317936000478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936000479 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 317936000480 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 317936000481 active site 317936000482 ribulose/triose binding site [chemical binding]; other site 317936000483 phosphate binding site [ion binding]; other site 317936000484 substrate (anthranilate) binding pocket [chemical binding]; other site 317936000485 product (indole) binding pocket [chemical binding]; other site 317936000486 Predicted membrane protein [Function unknown]; Region: COG3431 317936000487 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 317936000488 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 317936000489 active site 317936000490 catalytic residues [active] 317936000491 metal binding site [ion binding]; metal-binding site 317936000492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936000493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 317936000494 FtsX-like permease family; Region: FtsX; pfam02687 317936000495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936000496 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936000497 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936000498 TPR repeat; Region: TPR_11; pfam13414 317936000499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936000500 binding surface 317936000501 TPR motif; other site 317936000502 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936000503 binding surface 317936000504 TPR repeat; Region: TPR_11; pfam13414 317936000505 TPR motif; other site 317936000506 TPR repeat; Region: TPR_11; pfam13414 317936000507 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 317936000508 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 317936000509 NADP binding site [chemical binding]; other site 317936000510 active site 317936000511 putative substrate binding site [chemical binding]; other site 317936000512 biotin synthase; Region: bioB; TIGR00433 317936000513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936000514 FeS/SAM binding site; other site 317936000515 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 317936000516 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 317936000517 active site 317936000518 dimer interface [polypeptide binding]; other site 317936000519 metal binding site [ion binding]; metal-binding site 317936000520 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000521 putative active site [active] 317936000522 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 317936000523 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 317936000524 NodB motif; other site 317936000525 active site 317936000526 catalytic site [active] 317936000527 metal binding site [ion binding]; metal-binding site 317936000528 Predicted membrane protein [Function unknown]; Region: COG4280 317936000529 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 317936000530 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 317936000531 Ligand binding site; other site 317936000532 Putative Catalytic site; other site 317936000533 DXD motif; other site 317936000534 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 317936000535 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 317936000536 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936000537 Predicted membrane protein [Function unknown]; Region: COG3463 317936000538 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 317936000539 Predicted membrane protein [Function unknown]; Region: COG3463 317936000540 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 317936000541 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936000542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936000543 S-adenosylmethionine binding site [chemical binding]; other site 317936000544 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 317936000545 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 317936000546 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 317936000547 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 317936000548 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 317936000549 active site 317936000550 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 317936000551 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 317936000552 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 317936000553 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 317936000554 G-X-X-G motif; other site 317936000555 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 317936000556 RxxxH motif; other site 317936000557 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 317936000558 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 317936000559 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 317936000560 Bacterial PH domain; Region: DUF304; pfam03703 317936000561 ribonuclease P; Reviewed; Region: rnpA; PRK03031 317936000562 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 317936000563 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 317936000564 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 317936000565 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 317936000566 ligand binding site [chemical binding]; other site 317936000567 homodimer interface [polypeptide binding]; other site 317936000568 NAD(P) binding site [chemical binding]; other site 317936000569 trimer interface B [polypeptide binding]; other site 317936000570 trimer interface A [polypeptide binding]; other site 317936000571 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 317936000572 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 317936000573 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 317936000574 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936000575 active site 317936000576 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 317936000577 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 317936000578 Ycf35; Provisional; Region: ycf35; CHL00193 317936000579 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 317936000580 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 317936000581 PAS fold; Region: PAS_4; pfam08448 317936000582 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936000583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000584 putative active site [active] 317936000585 heme pocket [chemical binding]; other site 317936000586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936000587 GAF domain; Region: GAF; pfam01590 317936000588 PAS fold; Region: PAS_4; pfam08448 317936000589 PAS domain S-box; Region: sensory_box; TIGR00229 317936000590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000591 putative active site [active] 317936000592 heme pocket [chemical binding]; other site 317936000593 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936000594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936000595 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936000596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936000597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936000598 dimer interface [polypeptide binding]; other site 317936000599 phosphorylation site [posttranslational modification] 317936000600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000601 ATP binding site [chemical binding]; other site 317936000602 Mg2+ binding site [ion binding]; other site 317936000603 G-X-G motif; other site 317936000604 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936000605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936000606 active site 317936000607 phosphorylation site [posttranslational modification] 317936000608 intermolecular recognition site; other site 317936000609 dimerization interface [polypeptide binding]; other site 317936000610 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 317936000611 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 317936000612 substrate-cofactor binding pocket; other site 317936000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936000614 catalytic residue [active] 317936000615 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 317936000616 Helix-turn-helix domain; Region: HTH_25; pfam13413 317936000617 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 317936000618 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936000619 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 317936000620 Helix-turn-helix domain; Region: HTH_25; pfam13413 317936000621 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 317936000622 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 317936000623 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 317936000624 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 317936000625 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 317936000626 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 317936000627 generic binding surface I; other site 317936000628 generic binding surface II; other site 317936000629 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 317936000630 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936000631 Walker A/P-loop; other site 317936000632 ATP binding site [chemical binding]; other site 317936000633 Q-loop/lid; other site 317936000634 ABC transporter signature motif; other site 317936000635 Walker B; other site 317936000636 D-loop; other site 317936000637 H-loop/switch region; other site 317936000638 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 317936000639 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 317936000640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936000641 motif II; other site 317936000642 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 317936000643 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 317936000644 SnoaL-like domain; Region: SnoaL_2; pfam12680 317936000645 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 317936000646 Protein of unknown function (DUF433); Region: DUF433; cl01030 317936000647 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 317936000648 Exoribonuclease R [Transcription]; Region: VacB; COG0557 317936000649 RNB domain; Region: RNB; pfam00773 317936000650 ribosomal protein S18; Region: rps18; CHL00077 317936000651 ribosomal protein L33; Region: rpl33; CHL00104 317936000652 RDD family; Region: RDD; pfam06271 317936000653 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 317936000654 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 317936000655 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 317936000656 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 317936000657 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 317936000658 dimer interface [polypeptide binding]; other site 317936000659 putative functional site; other site 317936000660 putative MPT binding site; other site 317936000661 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936000662 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936000663 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 317936000664 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 317936000665 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 317936000666 dimerization domain swap beta strand [polypeptide binding]; other site 317936000667 regulatory protein interface [polypeptide binding]; other site 317936000668 active site 317936000669 regulatory phosphorylation site [posttranslational modification]; other site 317936000670 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 317936000671 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 317936000672 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 317936000673 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 317936000674 Uncharacterized conserved protein [Function unknown]; Region: COG2442 317936000675 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 317936000676 active site 317936000677 nucleophile elbow; other site 317936000678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936000679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936000680 non-specific DNA binding site [nucleotide binding]; other site 317936000681 salt bridge; other site 317936000682 sequence-specific DNA binding site [nucleotide binding]; other site 317936000683 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 317936000684 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 317936000685 intersubunit interface [polypeptide binding]; other site 317936000686 active site 317936000687 zinc binding site [ion binding]; other site 317936000688 Na+ binding site [ion binding]; other site 317936000689 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000690 putative active site [active] 317936000691 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 317936000692 active site 317936000693 catalytic residues [active] 317936000694 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 317936000695 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 317936000696 tetramer interface [polypeptide binding]; other site 317936000697 TPP-binding site [chemical binding]; other site 317936000698 heterodimer interface [polypeptide binding]; other site 317936000699 phosphorylation loop region [posttranslational modification] 317936000700 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936000701 HSP70 interaction site [polypeptide binding]; other site 317936000702 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 317936000703 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 317936000704 ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019 317936000705 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 317936000706 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 317936000707 Bacterial SH3 domain; Region: SH3_3; pfam08239 317936000708 Bacterial SH3 domain; Region: SH3_3; pfam08239 317936000709 Protein of unknown function (DUF4058); Region: DUF4058; pfam13267 317936000710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 317936000711 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936000712 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936000713 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 317936000714 catalytic triad [active] 317936000715 conserved cis-peptide bond; other site 317936000716 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 317936000717 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 317936000718 E3 interaction surface; other site 317936000719 lipoyl attachment site [posttranslational modification]; other site 317936000720 e3 binding domain; Region: E3_binding; pfam02817 317936000721 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 317936000722 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 317936000723 active site 317936000724 nucleophile elbow; other site 317936000725 Predicted integral membrane protein [Function unknown]; Region: COG5542 317936000726 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 317936000727 PLD-like domain; Region: PLDc_2; pfam13091 317936000728 putative active site [active] 317936000729 catalytic site [active] 317936000730 DEAD-like helicases superfamily; Region: DEXDc; smart00487 317936000731 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 317936000732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936000733 nucleotide binding region [chemical binding]; other site 317936000734 ATP-binding site [chemical binding]; other site 317936000735 Uncharacterized conserved protein [Function unknown]; Region: COG1479 317936000736 Protein of unknown function DUF262; Region: DUF262; pfam03235 317936000737 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 317936000738 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 317936000739 cofactor binding site; other site 317936000740 DNA binding site [nucleotide binding] 317936000741 substrate interaction site [chemical binding]; other site 317936000742 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 317936000743 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 317936000744 glutaminase active site [active] 317936000745 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 317936000746 dimer interface [polypeptide binding]; other site 317936000747 active site 317936000748 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 317936000749 dimer interface [polypeptide binding]; other site 317936000750 active site 317936000751 photosystem I subunit VII; Region: psaC; CHL00065 317936000752 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 317936000753 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 317936000754 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 317936000755 FMN binding site [chemical binding]; other site 317936000756 active site 317936000757 catalytic residues [active] 317936000758 substrate binding site [chemical binding]; other site 317936000759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 317936000760 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 317936000761 catalytic triad [active] 317936000762 putative active site [active] 317936000763 Predicted GTPase [General function prediction only]; Region: COG3596 317936000764 YfjP GTPase; Region: YfjP; cd11383 317936000765 G1 box; other site 317936000766 GTP/Mg2+ binding site [chemical binding]; other site 317936000767 Switch I region; other site 317936000768 G2 box; other site 317936000769 Switch II region; other site 317936000770 G3 box; other site 317936000771 G4 box; other site 317936000772 Uncharacterized conserved protein [Function unknown]; Region: COG1801 317936000773 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 317936000774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 317936000775 septum formation inhibitor; Reviewed; Region: minC; PRK00513 317936000776 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 317936000777 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 317936000778 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 317936000779 Switch I; other site 317936000780 Switch II; other site 317936000781 cell division topological specificity factor MinE; Provisional; Region: PRK13988 317936000782 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 317936000783 Nitrogen regulatory protein P-II; Region: P-II; smart00938 317936000784 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 317936000785 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 317936000786 dimer interface [polypeptide binding]; other site 317936000787 substrate binding site [chemical binding]; other site 317936000788 ATP binding site [chemical binding]; other site 317936000789 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 317936000790 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 317936000791 active site 317936000792 catalytic triad [active] 317936000793 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 317936000794 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 317936000795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936000796 FeS/SAM binding site; other site 317936000797 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 317936000798 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 317936000799 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 317936000800 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936000801 RNA binding surface [nucleotide binding]; other site 317936000802 heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245 317936000803 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 317936000804 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 317936000805 EamA-like transporter family; Region: EamA; pfam00892 317936000806 EamA-like transporter family; Region: EamA; pfam00892 317936000807 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 317936000808 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 317936000809 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 317936000810 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 317936000811 putative NAD(P) binding site [chemical binding]; other site 317936000812 catalytic Zn binding site [ion binding]; other site 317936000813 PIN domain; Region: PIN_3; pfam13470 317936000814 DNA binding domain, excisionase family; Region: excise; TIGR01764 317936000815 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 317936000816 active site 317936000817 putative DNA-binding cleft [nucleotide binding]; other site 317936000818 dimer interface [polypeptide binding]; other site 317936000819 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 317936000820 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 317936000821 phosphate binding site [ion binding]; other site 317936000822 putative substrate binding pocket [chemical binding]; other site 317936000823 dimer interface [polypeptide binding]; other site 317936000824 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 317936000825 dihydroorotase; Provisional; Region: PRK07575 317936000826 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 317936000827 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 317936000828 active site 317936000829 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 317936000830 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 317936000831 Catalytic site [active] 317936000832 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 317936000833 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 317936000834 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 317936000835 MOSC domain; Region: MOSC; pfam03473 317936000836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936000837 active site 317936000838 phosphorylation site [posttranslational modification] 317936000839 intermolecular recognition site; other site 317936000840 dimerization interface [polypeptide binding]; other site 317936000841 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936000842 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936000843 metal binding site [ion binding]; metal-binding site 317936000844 active site 317936000845 I-site; other site 317936000846 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936000847 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 317936000848 4Fe-4S binding domain; Region: Fer4_6; pfam12837 317936000849 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 317936000850 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 317936000851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936000852 Walker A motif; other site 317936000853 ATP binding site [chemical binding]; other site 317936000854 Walker B motif; other site 317936000855 negative regulator GrlR; Provisional; Region: PRK14051 317936000856 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 317936000857 RxxxH motif; other site 317936000858 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 317936000859 Predicted membrane protein [Function unknown]; Region: COG4330 317936000860 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 317936000861 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 317936000862 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 317936000863 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 317936000864 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 317936000865 MgtC family; Region: MgtC; pfam02308 317936000866 recombination protein F; Reviewed; Region: recF; PRK00064 317936000867 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 317936000868 Walker A/P-loop; other site 317936000869 ATP binding site [chemical binding]; other site 317936000870 Q-loop/lid; other site 317936000871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936000872 ABC transporter signature motif; other site 317936000873 Walker B; other site 317936000874 D-loop; other site 317936000875 H-loop/switch region; other site 317936000876 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 317936000877 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 317936000878 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936000879 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 317936000880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936000881 motif II; other site 317936000882 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 317936000883 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 317936000884 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 317936000885 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 317936000886 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 317936000887 active site 317936000888 substrate binding site [chemical binding]; other site 317936000889 metal binding site [ion binding]; metal-binding site 317936000890 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000891 putative active site [active] 317936000892 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936000893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936000894 active site 317936000895 phosphorylation site [posttranslational modification] 317936000896 intermolecular recognition site; other site 317936000897 dimerization interface [polypeptide binding]; other site 317936000898 agmatinase; Region: agmatinase; TIGR01230 317936000899 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 317936000900 putative active site [active] 317936000901 Mn binding site [ion binding]; other site 317936000902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936000903 S-adenosylmethionine binding site [chemical binding]; other site 317936000904 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 317936000905 nucleotide binding site/active site [active] 317936000906 HIT family signature motif; other site 317936000907 catalytic residue [active] 317936000908 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 317936000909 heterodimer interface [polypeptide binding]; other site 317936000910 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 317936000911 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 317936000912 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936000913 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936000914 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 317936000915 glutamate--cysteine ligase, cyanobacterial, putative; Region: gshA_cyano; TIGR02048 317936000916 Predicted membrane protein [Function unknown]; Region: COG4244 317936000917 Predicted membrane protein [Function unknown]; Region: COG4244 317936000918 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 317936000919 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 317936000920 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 317936000921 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 317936000922 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 317936000923 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 317936000924 Subunit I/III interface [polypeptide binding]; other site 317936000925 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936000926 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 317936000927 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 317936000928 Ligand Binding Site [chemical binding]; other site 317936000929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936000930 Ligand Binding Site [chemical binding]; other site 317936000931 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 317936000932 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936000933 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936000934 ligand binding site [chemical binding]; other site 317936000935 flexible hinge region; other site 317936000936 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936000937 putative switch regulator; other site 317936000938 non-specific DNA interactions [nucleotide binding]; other site 317936000939 DNA binding site [nucleotide binding] 317936000940 sequence specific DNA binding site [nucleotide binding]; other site 317936000941 putative cAMP binding site [chemical binding]; other site 317936000942 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 317936000943 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 317936000944 putative dimer interface [polypeptide binding]; other site 317936000945 active site pocket [active] 317936000946 putative cataytic base [active] 317936000947 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 317936000948 DNA photolyase; Region: DNA_photolyase; pfam00875 317936000949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 317936000950 FOG: CBS domain [General function prediction only]; Region: COG0517 317936000951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000952 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936000953 putative active site [active] 317936000954 heme pocket [chemical binding]; other site 317936000955 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 317936000956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936000957 putative active site [active] 317936000958 heme pocket [chemical binding]; other site 317936000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936000960 dimer interface [polypeptide binding]; other site 317936000961 phosphorylation site [posttranslational modification] 317936000962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936000963 ATP binding site [chemical binding]; other site 317936000964 Mg2+ binding site [ion binding]; other site 317936000965 G-X-G motif; other site 317936000966 Response regulator receiver domain; Region: Response_reg; pfam00072 317936000967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936000968 active site 317936000969 phosphorylation site [posttranslational modification] 317936000970 intermolecular recognition site; other site 317936000971 dimerization interface [polypeptide binding]; other site 317936000972 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 317936000973 putative active site [active] 317936000974 putative metal binding residues [ion binding]; other site 317936000975 signature motif; other site 317936000976 putative dimer interface [polypeptide binding]; other site 317936000977 putative phosphate binding site [ion binding]; other site 317936000978 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 317936000979 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 317936000980 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936000981 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936000982 catalytic residue [active] 317936000983 Urease alpha-subunit, N-terminal domain; Region: Urease_alpha; pfam00449 317936000984 dihydroorotase; Provisional; Region: PRK09237 317936000985 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 317936000986 active site 317936000987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936000988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936000989 binding surface 317936000990 TPR motif; other site 317936000991 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936000992 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936000993 CHAT domain; Region: CHAT; pfam12770 317936000994 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936000995 putative active site [active] 317936000996 dihydrodipicolinate reductase; Provisional; Region: PRK00048 317936000997 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 317936000998 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 317936000999 precorrin-8X methylmutase; Validated; Region: PRK05953 317936001000 Precorrin-8X methylmutase; Region: CbiC; pfam02570 317936001001 Repair protein; Region: Repair_PSII; pfam04536 317936001002 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 317936001003 putative active site [active] 317936001004 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936001005 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936001006 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936001007 XisI protein; Region: XisI; pfam08869 317936001008 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001009 putative active site [active] 317936001010 magnesium chelatase subunit H; Provisional; Region: PRK12493 317936001011 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 317936001012 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 317936001013 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 317936001014 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 317936001015 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936001016 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 317936001017 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 317936001018 homodimer interface [polypeptide binding]; other site 317936001019 metal binding site [ion binding]; metal-binding site 317936001020 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 317936001021 homodimer interface [polypeptide binding]; other site 317936001022 active site 317936001023 putative chemical substrate binding site [chemical binding]; other site 317936001024 metal binding site [ion binding]; metal-binding site 317936001025 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936001026 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936001027 Homeodomain-like domain; Region: HTH_23; pfam13384 317936001028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 317936001029 Homeodomain-like domain; Region: HTH_32; pfam13565 317936001030 Winged helix-turn helix; Region: HTH_33; pfam13592 317936001031 DDE superfamily endonuclease; Region: DDE_3; pfam13358 317936001032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 317936001033 2TM domain; Region: 2TM; pfam13239 317936001034 Creatinine amidohydrolase; Region: Creatininase; pfam02633 317936001035 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 317936001036 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 317936001037 nucleotide binding site [chemical binding]; other site 317936001038 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 317936001039 amidase catalytic site [active] 317936001040 Zn binding residues [ion binding]; other site 317936001041 substrate binding site [chemical binding]; other site 317936001042 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 317936001043 Phytase; Region: Phytase; cl17685 317936001044 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 317936001045 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 317936001046 putative active site [active] 317936001047 catalytic site [active] 317936001048 putative metal binding site [ion binding]; other site 317936001049 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 317936001050 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 317936001051 putative active site [active] 317936001052 catalytic site [active] 317936001053 putative metal binding site [ion binding]; other site 317936001054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 317936001055 Calx-beta domain; Region: Calx-beta; cl02522 317936001056 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 317936001057 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 317936001058 Protein kinase domain; Region: Pkinase; pfam00069 317936001059 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936001060 active site 317936001061 ATP binding site [chemical binding]; other site 317936001062 substrate binding site [chemical binding]; other site 317936001063 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936001064 substrate binding site [chemical binding]; other site 317936001065 activation loop (A-loop); other site 317936001066 activation loop (A-loop); other site 317936001067 AAA ATPase domain; Region: AAA_16; pfam13191 317936001068 Predicted ATPase [General function prediction only]; Region: COG3899 317936001069 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936001070 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936001071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001073 dimer interface [polypeptide binding]; other site 317936001074 phosphorylation site [posttranslational modification] 317936001075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001076 ATP binding site [chemical binding]; other site 317936001077 Mg2+ binding site [ion binding]; other site 317936001078 G-X-G motif; other site 317936001079 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936001080 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936001081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001082 active site 317936001083 phosphorylation site [posttranslational modification] 317936001084 intermolecular recognition site; other site 317936001085 dimerization interface [polypeptide binding]; other site 317936001086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936001087 DNA binding residues [nucleotide binding] 317936001088 dimerization interface [polypeptide binding]; other site 317936001089 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 317936001090 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 317936001091 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 317936001092 active site 317936001093 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 317936001094 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 317936001095 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 317936001096 Active site cavity [active] 317936001097 catalytic acid [active] 317936001098 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936001099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936001100 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 317936001101 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936001102 DXD motif; other site 317936001103 Electron transfer DM13; Region: DM13; pfam10517 317936001104 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 317936001105 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 317936001106 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 317936001107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001108 dimer interface [polypeptide binding]; other site 317936001109 phosphorylation site [posttranslational modification] 317936001110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001111 ATP binding site [chemical binding]; other site 317936001112 Mg2+ binding site [ion binding]; other site 317936001113 G-X-G motif; other site 317936001114 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936001115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001116 active site 317936001117 phosphorylation site [posttranslational modification] 317936001118 intermolecular recognition site; other site 317936001119 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001120 dimerization interface [polypeptide binding]; other site 317936001121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001122 dimer interface [polypeptide binding]; other site 317936001123 phosphorylation site [posttranslational modification] 317936001124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001125 ATP binding site [chemical binding]; other site 317936001126 Mg2+ binding site [ion binding]; other site 317936001127 G-X-G motif; other site 317936001128 Response regulator receiver domain; Region: Response_reg; pfam00072 317936001129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001130 active site 317936001131 phosphorylation site [posttranslational modification] 317936001132 intermolecular recognition site; other site 317936001133 dimerization interface [polypeptide binding]; other site 317936001134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936001135 Coenzyme A binding pocket [chemical binding]; other site 317936001136 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 317936001137 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 317936001138 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 317936001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001140 Mg2+ binding site [ion binding]; other site 317936001141 G-X-G motif; other site 317936001142 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 317936001143 anchoring element; other site 317936001144 dimer interface [polypeptide binding]; other site 317936001145 ATP binding site [chemical binding]; other site 317936001146 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 317936001147 active site 317936001148 putative metal-binding site [ion binding]; other site 317936001149 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 317936001150 RNA polymerase sigma factor RpoD; Validated; Region: PRK07406 317936001151 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936001152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936001153 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936001154 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936001155 DNA binding residues [nucleotide binding] 317936001156 light-harvesting-like protein 3; Provisional; Region: PLN00014 317936001157 DNA gyrase subunit A; Validated; Region: PRK05560 317936001158 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 317936001159 CAP-like domain; other site 317936001160 active site 317936001161 primary dimer interface [polypeptide binding]; other site 317936001162 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936001163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936001164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936001165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936001166 Response regulator receiver domain; Region: Response_reg; pfam00072 317936001167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001168 active site 317936001169 phosphorylation site [posttranslational modification] 317936001170 intermolecular recognition site; other site 317936001171 dimerization interface [polypeptide binding]; other site 317936001172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936001173 binding surface 317936001174 TPR repeat; Region: TPR_11; pfam13414 317936001175 TPR motif; other site 317936001176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936001177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936001178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936001179 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936001180 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001181 Uncharacterized conserved protein [Function unknown]; Region: COG1434 317936001182 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 317936001183 putative active site [active] 317936001184 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 317936001185 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 317936001186 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 317936001187 protein binding site [polypeptide binding]; other site 317936001188 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 317936001189 Catalytic dyad [active] 317936001190 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936001191 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936001192 active site 317936001193 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 317936001194 RNA binding site [nucleotide binding]; other site 317936001195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001196 putative active site [active] 317936001197 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 317936001198 active site 317936001199 SAM binding site [chemical binding]; other site 317936001200 homodimer interface [polypeptide binding]; other site 317936001201 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 317936001202 Precorrin-8X methylmutase; Region: CbiC; pfam02570 317936001203 Predicted membrane protein [Function unknown]; Region: COG2119 317936001204 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 317936001205 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 317936001206 hypothetical protein; Reviewed; Region: PRK00024 317936001207 Helix-hairpin-helix motif; Region: HHH; pfam00633 317936001208 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 317936001209 MPN+ (JAMM) motif; other site 317936001210 Zinc-binding site [ion binding]; other site 317936001211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 317936001212 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936001213 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 317936001214 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 317936001215 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 317936001216 dimerization interface [polypeptide binding]; other site 317936001217 active site 317936001218 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 317936001219 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 317936001220 enolase; Provisional; Region: eno; PRK00077 317936001221 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 317936001222 dimer interface [polypeptide binding]; other site 317936001223 metal binding site [ion binding]; metal-binding site 317936001224 substrate binding pocket [chemical binding]; other site 317936001225 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 317936001226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936001227 S-adenosylmethionine binding site [chemical binding]; other site 317936001228 Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109 317936001229 DNA polymerase III subunit delta'; Validated; Region: PRK07399 317936001230 DNA polymerase III subunit delta'; Validated; Region: PRK08485 317936001231 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936001232 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936001233 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936001234 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 317936001235 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936001236 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 317936001237 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 317936001238 Cl- selectivity filter; other site 317936001239 Cl- binding residues [ion binding]; other site 317936001240 pore gating glutamate residue; other site 317936001241 dimer interface [polypeptide binding]; other site 317936001242 H+/Cl- coupling transport residue; other site 317936001243 FOG: CBS domain [General function prediction only]; Region: COG0517 317936001244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 317936001245 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 317936001246 Ligand Binding Site [chemical binding]; other site 317936001247 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936001248 Ligand Binding Site [chemical binding]; other site 317936001249 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 317936001250 MPN+ (JAMM) motif; other site 317936001251 Zinc-binding site [ion binding]; other site 317936001252 hypothetical protein; Validated; Region: PRK07411 317936001253 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 317936001254 ATP binding site [chemical binding]; other site 317936001255 substrate interface [chemical binding]; other site 317936001256 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 317936001257 active site residue [active] 317936001258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936001259 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 317936001260 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 317936001261 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 317936001262 Walker A/P-loop; other site 317936001263 ATP binding site [chemical binding]; other site 317936001264 Q-loop/lid; other site 317936001265 ABC transporter signature motif; other site 317936001266 Walker B; other site 317936001267 D-loop; other site 317936001268 H-loop/switch region; other site 317936001269 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 317936001270 dimer interface [polypeptide binding]; other site 317936001271 motif 1; other site 317936001272 active site 317936001273 motif 2; other site 317936001274 motif 3; other site 317936001275 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 317936001276 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 317936001277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936001278 Coenzyme A binding pocket [chemical binding]; other site 317936001279 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 317936001280 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 317936001281 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936001282 NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363 317936001283 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936001284 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 317936001285 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 317936001286 TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950 317936001287 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936001288 catalytic residues [active] 317936001289 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 317936001290 4Fe-4S binding domain; Region: Fer4; pfam00037 317936001291 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 317936001292 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 317936001293 Uncharacterized conserved protein [Function unknown]; Region: COG5607 317936001294 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 317936001295 active site 317936001296 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 317936001297 active site 1 [active] 317936001298 dimer interface [polypeptide binding]; other site 317936001299 hexamer interface [polypeptide binding]; other site 317936001300 active site 2 [active] 317936001301 TetR family transcriptional regulator; Provisional; Region: PRK14996 317936001302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936001303 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 317936001304 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 317936001305 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 317936001306 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 317936001307 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 317936001308 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936001309 active site 317936001310 metal binding site [ion binding]; metal-binding site 317936001311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 317936001312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936001313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 317936001314 dimerization interface [polypeptide binding]; other site 317936001315 hypothetical protein; Provisional; Region: PRK07394 317936001316 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 317936001317 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 317936001318 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 317936001319 dimerization interface [polypeptide binding]; other site 317936001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 317936001321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 317936001322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 317936001323 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 317936001324 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 317936001325 DNA binding residues [nucleotide binding] 317936001326 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082 317936001327 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 317936001328 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 317936001329 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 317936001330 Phosphotransferase enzyme family; Region: APH; pfam01636 317936001331 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 317936001332 substrate binding site [chemical binding]; other site 317936001333 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 317936001334 putative heme binding site [chemical binding]; other site 317936001335 PAS fold; Region: PAS_4; pfam08448 317936001336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001337 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001338 dimer interface [polypeptide binding]; other site 317936001339 phosphorylation site [posttranslational modification] 317936001340 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001341 ATP binding site [chemical binding]; other site 317936001342 Mg2+ binding site [ion binding]; other site 317936001343 G-X-G motif; other site 317936001344 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936001345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001346 active site 317936001347 phosphorylation site [posttranslational modification] 317936001348 intermolecular recognition site; other site 317936001349 dimerization interface [polypeptide binding]; other site 317936001350 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 317936001351 Chemotaxis phosphatase CheX; Region: CheX; cl15816 317936001352 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936001353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001354 active site 317936001355 phosphorylation site [posttranslational modification] 317936001356 intermolecular recognition site; other site 317936001357 dimerization interface [polypeptide binding]; other site 317936001358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 317936001359 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936001360 putative binding surface; other site 317936001361 active site 317936001362 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 317936001363 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 317936001364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001365 ATP binding site [chemical binding]; other site 317936001366 Mg2+ binding site [ion binding]; other site 317936001367 G-X-G motif; other site 317936001368 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 317936001369 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 317936001370 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 317936001371 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 317936001372 dimerization interface [polypeptide binding]; other site 317936001373 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 317936001374 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936001375 dimer interface [polypeptide binding]; other site 317936001376 putative CheW interface [polypeptide binding]; other site 317936001377 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 317936001378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001379 active site 317936001380 phosphorylation site [posttranslational modification] 317936001381 intermolecular recognition site; other site 317936001382 dimerization interface [polypeptide binding]; other site 317936001383 CheB methylesterase; Region: CheB_methylest; pfam01339 317936001384 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 317936001385 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 317936001386 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 317936001387 Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229 317936001388 Staphylococcal nuclease homologues; Region: SNc; smart00318 317936001389 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 317936001390 Catalytic site; other site 317936001391 cobalt transport protein CbiM; Validated; Region: PRK08319 317936001392 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 317936001393 cobalt transport protein CbiN; Provisional; Region: PRK02898 317936001394 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 317936001395 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 317936001396 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 317936001397 Walker A/P-loop; other site 317936001398 ATP binding site [chemical binding]; other site 317936001399 Q-loop/lid; other site 317936001400 ABC transporter signature motif; other site 317936001401 Walker B; other site 317936001402 D-loop; other site 317936001403 H-loop/switch region; other site 317936001404 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 317936001405 Bacterial Ig-like domain; Region: Big_5; pfam13205 317936001406 MG2 domain; Region: A2M_N; pfam01835 317936001407 Alpha-2-macroglobulin family; Region: A2M; pfam00207 317936001408 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 317936001409 surface patch; other site 317936001410 specificity defining residues; other site 317936001411 Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953 317936001412 Transglycosylase; Region: Transgly; pfam00912 317936001413 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 317936001414 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 317936001415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001416 dimer interface [polypeptide binding]; other site 317936001417 phosphorylation site [posttranslational modification] 317936001418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001419 ATP binding site [chemical binding]; other site 317936001420 Mg2+ binding site [ion binding]; other site 317936001421 G-X-G motif; other site 317936001422 Response regulator receiver domain; Region: Response_reg; pfam00072 317936001423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001424 active site 317936001425 phosphorylation site [posttranslational modification] 317936001426 intermolecular recognition site; other site 317936001427 dimerization interface [polypeptide binding]; other site 317936001428 Response regulator receiver domain; Region: Response_reg; pfam00072 317936001429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001430 active site 317936001431 phosphorylation site [posttranslational modification] 317936001432 intermolecular recognition site; other site 317936001433 dimerization interface [polypeptide binding]; other site 317936001434 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001436 dimer interface [polypeptide binding]; other site 317936001437 phosphorylation site [posttranslational modification] 317936001438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001439 ATP binding site [chemical binding]; other site 317936001440 Mg2+ binding site [ion binding]; other site 317936001441 G-X-G motif; other site 317936001442 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 317936001443 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 317936001444 active site 317936001445 substrate binding site [chemical binding]; other site 317936001446 cosubstrate binding site; other site 317936001447 catalytic site [active] 317936001448 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 317936001449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936001450 dimer interface [polypeptide binding]; other site 317936001451 conserved gate region; other site 317936001452 putative PBP binding loops; other site 317936001453 ABC-ATPase subunit interface; other site 317936001454 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936001455 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001456 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936001457 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001458 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001459 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 317936001460 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 317936001461 FAD binding pocket [chemical binding]; other site 317936001462 FAD binding motif [chemical binding]; other site 317936001463 phosphate binding motif [ion binding]; other site 317936001464 beta-alpha-beta structure motif; other site 317936001465 NAD binding pocket [chemical binding]; other site 317936001466 Heme binding pocket [chemical binding]; other site 317936001467 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936001468 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936001469 catalytic loop [active] 317936001470 iron binding site [ion binding]; other site 317936001471 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 317936001472 hypothetical protein; Validated; Region: PRK07413 317936001473 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 317936001474 Walker A motif; other site 317936001475 homodimer interface [polypeptide binding]; other site 317936001476 ATP binding site [chemical binding]; other site 317936001477 hydroxycobalamin binding site [chemical binding]; other site 317936001478 Walker B motif; other site 317936001479 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 317936001480 Walker A motif; other site 317936001481 homodimer interface [polypeptide binding]; other site 317936001482 ATP binding site [chemical binding]; other site 317936001483 hydroxycobalamin binding site [chemical binding]; other site 317936001484 Walker B motif; other site 317936001485 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 317936001486 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 317936001487 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 317936001488 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 317936001489 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 317936001490 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 317936001491 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 317936001492 protein binding site [polypeptide binding]; other site 317936001493 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 317936001494 Catalytic dyad [active] 317936001495 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 317936001496 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001498 ATP binding site [chemical binding]; other site 317936001499 Mg2+ binding site [ion binding]; other site 317936001500 G-X-G motif; other site 317936001501 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936001502 catalytic core [active] 317936001503 glucokinase; Provisional; Region: glk; PRK00292 317936001504 glucokinase, proteobacterial type; Region: glk; TIGR00749 317936001505 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 317936001506 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 317936001507 putative active site [active] 317936001508 substrate binding site [chemical binding]; other site 317936001509 putative cosubstrate binding site; other site 317936001510 catalytic site [active] 317936001511 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 317936001512 substrate binding site [chemical binding]; other site 317936001513 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 317936001514 Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478 317936001515 active site 317936001516 catalytic triad [active] 317936001517 TrkA-N domain; Region: TrkA_N; pfam02254 317936001518 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 317936001519 TrkA-C domain; Region: TrkA_C; pfam02080 317936001520 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 317936001521 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 317936001522 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 317936001523 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 317936001524 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 317936001525 active site 317936001526 homodimer interface [polypeptide binding]; other site 317936001527 catalytic site [active] 317936001528 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 317936001529 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 317936001530 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 317936001531 shikimate binding site; other site 317936001532 NAD(P) binding site [chemical binding]; other site 317936001533 hydrolase, alpha/beta fold family protein; Region: PLN02824 317936001534 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936001535 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936001536 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936001537 inhibitor-cofactor binding pocket; inhibition site 317936001538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936001539 catalytic residue [active] 317936001540 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 317936001541 5-oxoprolinase; Region: PLN02666 317936001542 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 317936001543 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 317936001544 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 317936001545 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 317936001546 M28 Zn-Peptidases; Region: M28_like_1; cd05640 317936001547 Peptidase family M28; Region: Peptidase_M28; pfam04389 317936001548 metal binding site [ion binding]; metal-binding site 317936001549 molecular chaperone DnaK; Provisional; Region: PRK13410 317936001550 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 317936001551 nucleotide binding site [chemical binding]; other site 317936001552 NEF interaction site [polypeptide binding]; other site 317936001553 SBD interface [polypeptide binding]; other site 317936001554 chaperone protein DnaJ; Provisional; Region: PRK14299 317936001555 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936001556 HSP70 interaction site [polypeptide binding]; other site 317936001557 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 317936001558 substrate binding site [polypeptide binding]; other site 317936001559 dimer interface [polypeptide binding]; other site 317936001560 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936001561 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 317936001562 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936001563 HSP70 interaction site [polypeptide binding]; other site 317936001564 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 317936001565 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 317936001566 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 317936001567 catalytic residue [active] 317936001568 putative FPP diphosphate binding site; other site 317936001569 putative FPP binding hydrophobic cleft; other site 317936001570 dimer interface [polypeptide binding]; other site 317936001571 putative IPP diphosphate binding site; other site 317936001572 Uncharacterized conserved protein [Function unknown]; Region: COG1624 317936001573 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 317936001574 diaminopimelate decarboxylase; Region: lysA; TIGR01048 317936001575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 317936001576 active site 317936001577 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 317936001578 substrate binding site [chemical binding]; other site 317936001579 catalytic residues [active] 317936001580 dimer interface [polypeptide binding]; other site 317936001581 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 317936001582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 317936001583 Clp protease ATP binding subunit; Region: clpC; CHL00095 317936001584 Clp amino terminal domain; Region: Clp_N; pfam02861 317936001585 Clp amino terminal domain; Region: Clp_N; pfam02861 317936001586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936001587 Walker A motif; other site 317936001588 ATP binding site [chemical binding]; other site 317936001589 Walker B motif; other site 317936001590 arginine finger; other site 317936001591 UvrB/uvrC motif; Region: UVR; pfam02151 317936001592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936001593 Walker A motif; other site 317936001594 ATP binding site [chemical binding]; other site 317936001595 Walker B motif; other site 317936001596 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 317936001597 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 317936001598 AAA ATPase domain; Region: AAA_16; pfam13191 317936001599 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 317936001600 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 317936001601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936001602 Walker A motif; other site 317936001603 ATP binding site [chemical binding]; other site 317936001604 Walker B motif; other site 317936001605 arginine finger; other site 317936001606 Transmembrane proteins 14C; Region: Tmemb_14; pfam03647 317936001607 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936001608 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936001609 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936001611 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936001612 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936001613 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936001614 filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901 317936001615 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 317936001616 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936001617 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936001618 Phosphotransferase enzyme family; Region: APH; pfam01636 317936001619 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 317936001620 substrate binding site [chemical binding]; other site 317936001621 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 317936001622 active site 317936001623 O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445 317936001624 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 317936001625 acyl-activating enzyme (AAE) consensus motif; other site 317936001626 putative AMP binding site [chemical binding]; other site 317936001627 putative active site [active] 317936001628 putative CoA binding site [chemical binding]; other site 317936001629 O-succinylbenzoate synthase; Provisional; Region: PRK02714 317936001630 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 317936001631 active site 317936001632 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419 317936001633 UbiA prenyltransferase family; Region: UbiA; pfam01040 317936001634 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 317936001635 chorismate binding enzyme; Region: Chorismate_bind; cl10555 317936001636 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 317936001637 MPT binding site; other site 317936001638 trimer interface [polypeptide binding]; other site 317936001639 photosystem II reaction center protein Psb28; Provisional; Region: PRK13612 317936001640 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 317936001641 putative active site [active] 317936001642 dimerization interface [polypeptide binding]; other site 317936001643 putative tRNAtyr binding site [nucleotide binding]; other site 317936001644 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 317936001645 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936001646 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 317936001647 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 317936001648 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 317936001649 active site 317936001650 HIGH motif; other site 317936001651 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 317936001652 KMSKS motif; other site 317936001653 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 317936001654 tRNA binding surface [nucleotide binding]; other site 317936001655 anticodon binding site; other site 317936001656 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936001657 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936001658 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 317936001659 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 317936001660 putative Cl- selectivity filter; other site 317936001661 putative pore gating glutamate residue; other site 317936001662 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 317936001663 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 317936001664 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 317936001665 ATP binding site [chemical binding]; other site 317936001666 putative Mg++ binding site [ion binding]; other site 317936001667 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936001668 nucleotide binding region [chemical binding]; other site 317936001669 ATP-binding site [chemical binding]; other site 317936001670 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001671 putative active site [active] 317936001672 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 317936001673 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 317936001674 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 317936001675 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 317936001676 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 317936001677 active site 317936001678 (T/H)XGH motif; other site 317936001679 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 317936001680 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 317936001681 putative active site [active] 317936001682 Zn binding site [ion binding]; other site 317936001683 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 317936001684 Mechanosensitive ion channel; Region: MS_channel; pfam00924 317936001685 S-layer homology domain; Region: SLH; pfam00395 317936001686 S-layer homology domain; Region: SLH; pfam00395 317936001687 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 317936001688 YcfA-like protein; Region: YcfA; cl00752 317936001689 hydrolase, alpha/beta fold family protein; Region: PLN02824 317936001690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936001691 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936001692 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936001693 active site 317936001694 ATP binding site [chemical binding]; other site 317936001695 substrate binding site [chemical binding]; other site 317936001696 activation loop (A-loop); other site 317936001697 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 317936001698 RimM N-terminal domain; Region: RimM; pfam01782 317936001699 PRC-barrel domain; Region: PRC; pfam05239 317936001700 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 317936001701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936001702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936001703 homodimer interface [polypeptide binding]; other site 317936001704 catalytic residue [active] 317936001705 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 317936001706 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 317936001707 substrate binding site [chemical binding]; other site 317936001708 catalytic Zn binding site [ion binding]; other site 317936001709 NAD binding site [chemical binding]; other site 317936001710 structural Zn binding site [ion binding]; other site 317936001711 dimer interface [polypeptide binding]; other site 317936001712 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001713 putative active site [active] 317936001714 S-formylglutathione hydrolase; Region: PLN02442 317936001715 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 317936001716 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 317936001717 DHH family; Region: DHH; pfam01368 317936001718 FOG: CBS domain [General function prediction only]; Region: COG0517 317936001719 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 317936001720 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 317936001721 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 317936001722 active site 317936001723 NTP binding site [chemical binding]; other site 317936001724 metal binding triad [ion binding]; metal-binding site 317936001725 photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576 317936001726 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 317936001727 homopentamer interface [polypeptide binding]; other site 317936001728 active site 317936001729 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 317936001730 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 317936001731 putative catalytic cysteine [active] 317936001732 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001733 putative active site [active] 317936001734 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 317936001735 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 317936001736 putative di-iron ligands [ion binding]; other site 317936001737 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 317936001738 Fatty acid desaturase; Region: FA_desaturase; pfam00487 317936001739 putative di-iron ligands [ion binding]; other site 317936001740 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 317936001741 Fatty acid desaturase; Region: FA_desaturase; pfam00487 317936001742 Di-iron ligands [ion binding]; other site 317936001743 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 317936001744 Aluminium resistance protein; Region: Alum_res; pfam06838 317936001745 Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035 317936001746 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 317936001747 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 317936001748 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 317936001749 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 317936001750 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936001751 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936001752 structural tetrad; other site 317936001753 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936001754 HSP70 interaction site [polypeptide binding]; other site 317936001755 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 317936001756 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 317936001757 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 317936001758 Competence protein; Region: Competence; pfam03772 317936001759 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 317936001760 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 317936001761 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 317936001762 nucleotide binding site [chemical binding]; other site 317936001763 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 317936001764 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 317936001765 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 317936001766 homodimer interface [polypeptide binding]; other site 317936001767 Walker A motif; other site 317936001768 ATP binding site [chemical binding]; other site 317936001769 hydroxycobalamin binding site [chemical binding]; other site 317936001770 Walker B motif; other site 317936001771 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001772 putative active site [active] 317936001773 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 317936001774 RNA polymerase sigma factor; Validated; Region: PRK05949 317936001775 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936001776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936001777 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936001778 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936001779 DNA binding residues [nucleotide binding] 317936001780 HAS barrel domain; Region: HAS-barrel; pfam09378 317936001781 HerA helicase [Replication, recombination, and repair]; Region: COG0433 317936001782 Domain of unknown function DUF87; Region: DUF87; pfam01935 317936001783 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936001784 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 317936001785 C-terminal domain interface [polypeptide binding]; other site 317936001786 GSH binding site (G-site) [chemical binding]; other site 317936001787 dimer interface [polypeptide binding]; other site 317936001788 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 317936001789 dimer interface [polypeptide binding]; other site 317936001790 N-terminal domain interface [polypeptide binding]; other site 317936001791 substrate binding pocket (H-site) [chemical binding]; other site 317936001792 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 317936001793 Fasciclin domain; Region: Fasciclin; pfam02469 317936001794 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 317936001795 dihydroorotase; Provisional; Region: PRK07369 317936001796 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 317936001797 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 317936001798 active site 317936001799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936001800 catalytic core [active] 317936001801 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936001802 catalytic core [active] 317936001803 PAS domain S-box; Region: sensory_box; TIGR00229 317936001804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936001805 putative active site [active] 317936001806 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936001807 GAF domain; Region: GAF; pfam01590 317936001808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936001809 dimer interface [polypeptide binding]; other site 317936001810 phosphorylation site [posttranslational modification] 317936001811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001812 ATP binding site [chemical binding]; other site 317936001813 Mg2+ binding site [ion binding]; other site 317936001814 G-X-G motif; other site 317936001815 transcriptional regulator NarL; Provisional; Region: PRK10651 317936001816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936001817 active site 317936001818 phosphorylation site [posttranslational modification] 317936001819 intermolecular recognition site; other site 317936001820 dimerization interface [polypeptide binding]; other site 317936001821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936001822 DNA binding residues [nucleotide binding] 317936001823 GTPase Era; Reviewed; Region: era; PRK00089 317936001824 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 317936001825 G1 box; other site 317936001826 GTP/Mg2+ binding site [chemical binding]; other site 317936001827 Switch I region; other site 317936001828 G2 box; other site 317936001829 Switch II region; other site 317936001830 G3 box; other site 317936001831 G4 box; other site 317936001832 G5 box; other site 317936001833 KH domain; Region: KH_2; pfam07650 317936001834 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 317936001835 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936001836 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936001837 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001838 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936001839 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936001840 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 317936001841 Bacterial SH3 domain; Region: SH3_3; pfam08239 317936001842 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 317936001843 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 317936001844 active site 317936001845 metal binding site [ion binding]; metal-binding site 317936001846 CTP synthetase; Validated; Region: pyrG; PRK05380 317936001847 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 317936001848 Catalytic site [active] 317936001849 active site 317936001850 UTP binding site [chemical binding]; other site 317936001851 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 317936001852 active site 317936001853 putative oxyanion hole; other site 317936001854 catalytic triad [active] 317936001855 CHAT domain; Region: CHAT; cl17868 317936001856 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936001857 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936001858 structural tetrad; other site 317936001859 PQQ-like domain; Region: PQQ_2; pfam13360 317936001860 WD40 repeats; Region: WD40; smart00320 317936001861 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 317936001862 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 317936001863 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 317936001864 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001865 putative active site [active] 317936001866 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 317936001867 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 317936001868 putative active site [active] 317936001869 putative metal binding site [ion binding]; other site 317936001870 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936001871 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936001872 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936001873 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 317936001874 nudix motif; other site 317936001875 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 317936001876 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 317936001877 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 317936001878 homodimer interface [polypeptide binding]; other site 317936001879 NADP binding site [chemical binding]; other site 317936001880 substrate binding site [chemical binding]; other site 317936001881 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 317936001882 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 317936001883 substrate binding pocket [chemical binding]; other site 317936001884 chain length determination region; other site 317936001885 substrate-Mg2+ binding site; other site 317936001886 catalytic residues [active] 317936001887 aspartate-rich region 1; other site 317936001888 active site lid residues [active] 317936001889 aspartate-rich region 2; other site 317936001890 Divergent PAP2 family; Region: DUF212; pfam02681 317936001891 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 317936001892 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 317936001893 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 317936001894 active site 317936001895 hydrophilic channel; other site 317936001896 dimerization interface [polypeptide binding]; other site 317936001897 catalytic residues [active] 317936001898 active site lid [active] 317936001899 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936001900 putative active site [active] 317936001901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936001902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936001903 dimerization interface [polypeptide binding]; other site 317936001904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936001905 dimer interface [polypeptide binding]; other site 317936001906 phosphorylation site [posttranslational modification] 317936001907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936001908 ATP binding site [chemical binding]; other site 317936001909 Mg2+ binding site [ion binding]; other site 317936001910 G-X-G motif; other site 317936001911 S-adenosylmethionine synthetase; Validated; Region: PRK05250 317936001912 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 317936001913 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 317936001914 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 317936001915 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 317936001916 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 317936001917 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 317936001918 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 317936001919 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 317936001920 putative acyl-acceptor binding pocket; other site 317936001921 RNA ligase; Region: RNA_ligase; pfam09414 317936001922 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 317936001923 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936001924 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936001925 active site 317936001926 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 317936001927 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 317936001928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936001929 FeS/SAM binding site; other site 317936001930 TRAM domain; Region: TRAM; pfam01938 317936001931 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 317936001932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936001933 Walker A motif; other site 317936001934 ATP binding site [chemical binding]; other site 317936001935 Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541 317936001936 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 317936001937 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 317936001938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 317936001939 ATP binding site [chemical binding]; other site 317936001940 putative Mg++ binding site [ion binding]; other site 317936001941 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 317936001942 Tetratricopeptide repeat; Region: TPR_10; pfam13374 317936001943 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936001944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936001945 binding surface 317936001946 TPR motif; other site 317936001947 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936001948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936001949 binding surface 317936001950 TPR motif; other site 317936001951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936001952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936001953 CHAT domain; Region: CHAT; pfam12770 317936001954 cytochrome c-550; Provisional; Region: psbV; cl17239 317936001955 Dihaem cytochrome c; Region: DHC; pfam09626 317936001956 Predicted transcriptional regulator [Transcription]; Region: COG1959 317936001957 Transcriptional regulator; Region: Rrf2; pfam02082 317936001958 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 317936001959 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 317936001960 dimer interface [polypeptide binding]; other site 317936001961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936001962 catalytic residue [active] 317936001963 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936001964 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 317936001965 HSP70 interaction site [polypeptide binding]; other site 317936001966 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 317936001967 active site 317936001968 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 317936001969 active site 317936001970 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 317936001971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936001972 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936001974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936001975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936001976 DNA binding residues [nucleotide binding] 317936001977 Phosphotransferase enzyme family; Region: APH; pfam01636 317936001978 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 317936001979 PAS domain; Region: PAS_9; pfam13426 317936001980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936001981 PAS domain; Region: PAS_9; pfam13426 317936001982 putative active site [active] 317936001983 heme pocket [chemical binding]; other site 317936001984 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936001985 GAF domain; Region: GAF; cl17456 317936001986 PAS domain S-box; Region: sensory_box; TIGR00229 317936001987 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936001988 putative active site [active] 317936001989 heme pocket [chemical binding]; other site 317936001990 cyclase homology domain; Region: CHD; cd07302 317936001991 nucleotidyl binding site; other site 317936001992 metal binding site [ion binding]; metal-binding site 317936001993 dimer interface [polypeptide binding]; other site 317936001994 deoxyhypusine synthase-like protein; Provisional; Region: PRK00770 317936001995 deoxyhypusine synthase; Region: dhys; TIGR00321 317936001996 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 317936001997 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 317936001998 putative active site; other site 317936001999 catalytic residue [active] 317936002000 TPR repeat; Region: TPR_11; pfam13414 317936002001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002002 binding surface 317936002003 TPR motif; other site 317936002004 TPR repeat; Region: TPR_11; pfam13414 317936002005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002006 binding surface 317936002007 TPR motif; other site 317936002008 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936002009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002010 binding surface 317936002011 TPR motif; other site 317936002012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002013 binding surface 317936002014 TPR motif; other site 317936002015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002016 binding surface 317936002017 TPR motif; other site 317936002018 TPR repeat; Region: TPR_11; pfam13414 317936002019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002020 binding surface 317936002021 TPR motif; other site 317936002022 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936002023 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936002024 active site 317936002025 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936002026 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936002027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936002028 Response regulator receiver domain; Region: Response_reg; pfam00072 317936002029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936002030 active site 317936002031 phosphorylation site [posttranslational modification] 317936002032 intermolecular recognition site; other site 317936002033 dimerization interface [polypeptide binding]; other site 317936002034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936002036 dimer interface [polypeptide binding]; other site 317936002037 phosphorylation site [posttranslational modification] 317936002038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002039 ATP binding site [chemical binding]; other site 317936002040 Mg2+ binding site [ion binding]; other site 317936002041 G-X-G motif; other site 317936002042 Cache domain; Region: Cache_1; pfam02743 317936002043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936002044 dimerization interface [polypeptide binding]; other site 317936002045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002046 dimer interface [polypeptide binding]; other site 317936002047 phosphorylation site [posttranslational modification] 317936002048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002049 ATP binding site [chemical binding]; other site 317936002050 Mg2+ binding site [ion binding]; other site 317936002051 G-X-G motif; other site 317936002052 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936002053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936002054 active site 317936002055 phosphorylation site [posttranslational modification] 317936002056 intermolecular recognition site; other site 317936002057 dimerization interface [polypeptide binding]; other site 317936002058 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 317936002059 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 317936002060 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 317936002061 putative NAD(P) binding site [chemical binding]; other site 317936002062 active site 317936002063 putative substrate binding site [chemical binding]; other site 317936002064 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 317936002065 FMN binding site [chemical binding]; other site 317936002066 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 317936002067 substrate binding site [chemical binding]; other site 317936002068 putative catalytic residue [active] 317936002069 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936002070 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 317936002071 active site 317936002072 Acyl transferase domain; Region: Acyl_transf_1; cl08282 317936002073 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936002074 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 317936002075 active site 317936002076 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 317936002077 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 317936002078 putative NADP binding site [chemical binding]; other site 317936002079 active site 317936002080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936002081 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 317936002082 active site 317936002083 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 317936002084 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 317936002085 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936002086 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 317936002087 ParB-like nuclease domain; Region: ParB; smart00470 317936002088 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 317936002089 DNA methylase; Region: N6_N4_Mtase; cl17433 317936002090 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 317936002091 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 317936002092 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936002093 DevC protein; Region: devC; TIGR01185 317936002094 FtsX-like permease family; Region: FtsX; pfam02687 317936002095 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936002096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936002097 NAD(P) binding site [chemical binding]; other site 317936002098 active site 317936002099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 317936002100 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 317936002101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936002102 active site 317936002103 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 317936002104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936002105 active site 317936002106 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936002107 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 317936002108 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 317936002109 Ycf39; Provisional; Region: ycf39; CHL00194 317936002110 NAD(P) binding site [chemical binding]; other site 317936002111 putative active site [active] 317936002112 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 317936002113 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936002114 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 317936002115 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 317936002116 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 317936002117 nucleotide binding site [chemical binding]; other site 317936002118 NEF interaction site [polypeptide binding]; other site 317936002119 SBD interface [polypeptide binding]; other site 317936002120 Uncharacterized conserved protein [Function unknown]; Region: COG3287 317936002121 FIST N domain; Region: FIST; pfam08495 317936002122 FIST C domain; Region: FIST_C; pfam10442 317936002123 Uncharacterized conserved protein; Region: KxDL; pfam10241 317936002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002125 ATP binding site [chemical binding]; other site 317936002126 Mg2+ binding site [ion binding]; other site 317936002127 G-X-G motif; other site 317936002128 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 317936002129 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 317936002130 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 317936002131 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 317936002132 dimer interface [polypeptide binding]; other site 317936002133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936002134 catalytic residue [active] 317936002135 Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033 317936002136 putative catalytic residues [active] 317936002137 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 317936002138 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 317936002139 Subunit I/III interface [polypeptide binding]; other site 317936002140 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 317936002141 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 317936002142 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 317936002143 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 317936002144 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 317936002145 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 317936002146 4Fe-4S binding domain; Region: Fer4; cl02805 317936002147 Ferredoxin [Energy production and conversion]; Region: COG1146 317936002148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936002149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936002150 non-specific DNA binding site [nucleotide binding]; other site 317936002151 salt bridge; other site 317936002152 sequence-specific DNA binding site [nucleotide binding]; other site 317936002153 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936002154 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 317936002155 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 317936002156 dimerization interface [polypeptide binding]; other site 317936002157 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 317936002158 ATP binding site [chemical binding]; other site 317936002159 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 317936002160 active site 1 [active] 317936002161 dimer interface [polypeptide binding]; other site 317936002162 hexamer interface [polypeptide binding]; other site 317936002163 active site 2 [active] 317936002164 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 317936002165 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 317936002166 HupF/HypC family; Region: HupF_HypC; cl00394 317936002167 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 317936002168 Acylphosphatase; Region: Acylphosphatase; pfam00708 317936002169 HypF finger; Region: zf-HYPF; pfam07503 317936002170 HypF finger; Region: zf-HYPF; pfam07503 317936002171 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 317936002172 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 317936002173 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 317936002174 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936002175 non-specific DNA binding site [nucleotide binding]; other site 317936002176 salt bridge; other site 317936002177 sequence-specific DNA binding site [nucleotide binding]; other site 317936002178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936002179 Walker A motif; other site 317936002180 ATP binding site [chemical binding]; other site 317936002181 Walker B motif; other site 317936002182 Response regulator receiver domain; Region: Response_reg; pfam00072 317936002183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936002184 active site 317936002185 phosphorylation site [posttranslational modification] 317936002186 intermolecular recognition site; other site 317936002187 dimerization interface [polypeptide binding]; other site 317936002188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002190 phosphorylation site [posttranslational modification] 317936002191 dimer interface [polypeptide binding]; other site 317936002192 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002193 ATP binding site [chemical binding]; other site 317936002194 Mg2+ binding site [ion binding]; other site 317936002195 G-X-G motif; other site 317936002196 Response regulator receiver domain; Region: Response_reg; pfam00072 317936002197 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936002198 active site 317936002199 phosphorylation site [posttranslational modification] 317936002200 intermolecular recognition site; other site 317936002201 dimerization interface [polypeptide binding]; other site 317936002202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936002203 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 317936002204 FOG: CBS domain [General function prediction only]; Region: COG0517 317936002205 PAS domain; Region: PAS_9; pfam13426 317936002206 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002207 putative active site [active] 317936002208 heme pocket [chemical binding]; other site 317936002209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002210 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002211 putative active site [active] 317936002212 heme pocket [chemical binding]; other site 317936002213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002214 putative active site [active] 317936002215 heme pocket [chemical binding]; other site 317936002216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002217 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002218 putative active site [active] 317936002219 heme pocket [chemical binding]; other site 317936002220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002221 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002222 putative active site [active] 317936002223 heme pocket [chemical binding]; other site 317936002224 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002225 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002226 putative active site [active] 317936002227 heme pocket [chemical binding]; other site 317936002228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002229 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002230 putative active site [active] 317936002231 heme pocket [chemical binding]; other site 317936002232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002233 putative active site [active] 317936002234 heme pocket [chemical binding]; other site 317936002235 PAS domain; Region: PAS_9; pfam13426 317936002236 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002237 putative active site [active] 317936002238 heme pocket [chemical binding]; other site 317936002239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002240 PAS fold; Region: PAS_3; pfam08447 317936002241 putative active site [active] 317936002242 heme pocket [chemical binding]; other site 317936002243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002245 dimer interface [polypeptide binding]; other site 317936002246 phosphorylation site [posttranslational modification] 317936002247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002248 ATP binding site [chemical binding]; other site 317936002249 Mg2+ binding site [ion binding]; other site 317936002250 G-X-G motif; other site 317936002251 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936002252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 317936002253 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 317936002254 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 317936002255 Protein of unknown function (DUF512); Region: DUF512; pfam04459 317936002256 Bacitracin resistance protein BacA; Region: BacA; pfam02673 317936002257 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 317936002258 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936002259 Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514 317936002260 L-aspartate oxidase; Provisional; Region: PRK07395 317936002261 L-aspartate oxidase; Provisional; Region: PRK06175 317936002262 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 317936002263 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936002264 CHASE2 domain; Region: CHASE2; pfam05226 317936002265 PAS fold; Region: PAS_4; pfam08448 317936002266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002267 putative active site [active] 317936002268 heme pocket [chemical binding]; other site 317936002269 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936002270 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936002271 metal binding site [ion binding]; metal-binding site 317936002272 active site 317936002273 I-site; other site 317936002274 Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916 317936002275 substrate binding site [chemical binding]; other site 317936002276 putative active site [active] 317936002277 redox center [active] 317936002278 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 317936002279 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cd04722 317936002280 phosphate binding site [ion binding]; other site 317936002281 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 317936002282 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 317936002283 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936002284 FeS/SAM binding site; other site 317936002285 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 317936002286 DEAD-like helicases superfamily; Region: DEXDc; smart00487 317936002287 ATP binding site [chemical binding]; other site 317936002288 Mg++ binding site [ion binding]; other site 317936002289 motif III; other site 317936002290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936002291 nucleotide binding region [chemical binding]; other site 317936002292 ATP-binding site [chemical binding]; other site 317936002293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936002294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936002295 active site 317936002296 catalytic tetrad [active] 317936002297 Methyltransferase domain; Region: Methyltransf_26; pfam13659 317936002298 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 317936002299 DNA methylase; Region: N6_N4_Mtase; pfam01555 317936002300 YcfA-like protein; Region: YcfA; pfam07927 317936002301 Domain of unknown function (DUF1902); Region: DUF1902; pfam08972 317936002302 PUCC protein; Region: PUCC; pfam03209 317936002303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936002304 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 317936002305 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 317936002306 active site 317936002307 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 317936002308 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 317936002309 putative NAD(P) binding site [chemical binding]; other site 317936002310 catalytic Zn binding site [ion binding]; other site 317936002311 structural Zn binding site [ion binding]; other site 317936002312 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 317936002313 UbiA prenyltransferase family; Region: UbiA; pfam01040 317936002314 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 317936002315 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 317936002316 DTAP/Switch II; other site 317936002317 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 317936002318 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936002319 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 317936002320 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 317936002321 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 317936002322 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936002323 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936002324 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 317936002325 putative trimer interface [polypeptide binding]; other site 317936002326 putative CoA binding site [chemical binding]; other site 317936002327 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 317936002328 putative trimer interface [polypeptide binding]; other site 317936002329 putative active site [active] 317936002330 putative substrate binding site [chemical binding]; other site 317936002331 putative CoA binding site [chemical binding]; other site 317936002332 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936002333 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936002334 inhibitor-cofactor binding pocket; inhibition site 317936002335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936002336 catalytic residue [active] 317936002337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936002338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936002339 NAD(P) binding site [chemical binding]; other site 317936002340 active site 317936002341 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 317936002342 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 317936002343 active site 317936002344 dimer interface [polypeptide binding]; other site 317936002345 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936002346 Ligand Binding Site [chemical binding]; other site 317936002347 Molecular Tunnel; other site 317936002348 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 317936002349 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 317936002350 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 317936002351 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 317936002352 Walker A/P-loop; other site 317936002353 ATP binding site [chemical binding]; other site 317936002354 Q-loop/lid; other site 317936002355 ABC transporter signature motif; other site 317936002356 Walker B; other site 317936002357 D-loop; other site 317936002358 H-loop/switch region; other site 317936002359 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 317936002360 putative carbohydrate binding site [chemical binding]; other site 317936002361 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 317936002362 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936002363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936002364 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936002365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936002366 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936002367 catalytic residue [active] 317936002368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 317936002369 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 317936002370 ligand-binding site [chemical binding]; other site 317936002371 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936002372 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936002373 inhibitor-cofactor binding pocket; inhibition site 317936002374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936002375 catalytic residue [active] 317936002376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936002377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936002378 S-adenosylmethionine binding site [chemical binding]; other site 317936002379 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936002380 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936002381 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936002382 extended (e) SDRs; Region: SDR_e; cd08946 317936002383 NAD(P) binding site [chemical binding]; other site 317936002384 active site 317936002385 substrate binding site [chemical binding]; other site 317936002386 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936002387 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936002388 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 317936002389 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 317936002390 active site 317936002391 dimer interface [polypeptide binding]; other site 317936002392 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936002393 Ligand Binding Site [chemical binding]; other site 317936002394 Molecular Tunnel; other site 317936002395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936002396 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 317936002397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936002398 non-specific DNA binding site [nucleotide binding]; other site 317936002399 salt bridge; other site 317936002400 sequence-specific DNA binding site [nucleotide binding]; other site 317936002401 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 317936002402 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 317936002403 RNA binding site [nucleotide binding]; other site 317936002404 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 317936002405 RNA binding site [nucleotide binding]; other site 317936002406 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 317936002407 RNA binding site [nucleotide binding]; other site 317936002408 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 317936002409 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 317936002410 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 317936002411 active site 317936002412 catalytic residues [active] 317936002413 metal binding site [ion binding]; metal-binding site 317936002414 Ycf46; Provisional; Region: ycf46; CHL00195 317936002415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936002416 Walker A motif; other site 317936002417 ATP binding site [chemical binding]; other site 317936002418 Walker B motif; other site 317936002419 arginine finger; other site 317936002420 Bacterial SH3 domain; Region: SH3_3; cl17532 317936002421 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936002422 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002423 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936002424 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002425 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002426 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936002427 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002428 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002429 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 317936002430 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 317936002431 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 317936002432 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 317936002433 dihydrodipicolinate synthase; Region: dapA; TIGR00674 317936002434 dimer interface [polypeptide binding]; other site 317936002435 active site 317936002436 catalytic residue [active] 317936002437 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 317936002438 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 317936002439 trigger factor; Provisional; Region: tig; PRK01490 317936002440 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 317936002441 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 317936002442 Clp protease; Region: CLP_protease; pfam00574 317936002443 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 317936002444 oligomer interface [polypeptide binding]; other site 317936002445 active site residues [active] 317936002446 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 317936002447 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 317936002448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936002449 Walker A motif; other site 317936002450 ATP binding site [chemical binding]; other site 317936002451 Walker B motif; other site 317936002452 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 317936002453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936002454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936002455 Predicted transcriptional regulators [Transcription]; Region: COG1725 317936002456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 317936002457 DNA-binding site [nucleotide binding]; DNA binding site 317936002458 conserved hypothetical protein; Region: TIGR02231 317936002459 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 317936002460 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 317936002461 Transcriptional regulator [Transcription]; Region: LysR; COG0583 317936002462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936002463 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 317936002464 putative dimerization interface [polypeptide binding]; other site 317936002465 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936002466 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936002467 Hexamer interface [polypeptide binding]; other site 317936002468 Hexagonal pore residue; other site 317936002469 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936002470 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936002471 Hexamer interface [polypeptide binding]; other site 317936002472 Hexagonal pore residue; other site 317936002473 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 317936002474 putative trimer interface [polypeptide binding]; other site 317936002475 putative CoA binding site [chemical binding]; other site 317936002476 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 317936002477 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 317936002478 trimer interface [polypeptide binding]; other site 317936002479 active site 317936002480 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 317936002481 putative multimerization interface [polypeptide binding]; other site 317936002482 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 317936002483 putative multimerization interface [polypeptide binding]; other site 317936002484 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 317936002485 putative multimerization interface [polypeptide binding]; other site 317936002486 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 317936002487 Hexamer/Pentamer interface [polypeptide binding]; other site 317936002488 central pore; other site 317936002489 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936002490 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936002491 Hexamer interface [polypeptide binding]; other site 317936002492 Hexagonal pore residue; other site 317936002493 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936002494 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936002495 Hexamer interface [polypeptide binding]; other site 317936002496 Hexagonal pore residue; other site 317936002497 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 317936002498 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936002499 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 317936002500 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936002501 CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216 317936002502 Nitrogen regulatory protein P-II; Region: P-II; cl00412 317936002503 Domain of unknown function (DUF897); Region: DUF897; pfam05982 317936002504 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936002505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936002506 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936002507 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 317936002508 Protein export membrane protein; Region: SecD_SecF; cl14618 317936002509 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936002510 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936002511 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936002512 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936002513 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 317936002514 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 317936002515 Moco binding site; other site 317936002516 metal coordination site [ion binding]; other site 317936002517 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 317936002518 Electron transfer DM13; Region: DM13; pfam10517 317936002519 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 317936002520 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 317936002521 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 317936002522 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936002523 catalytic residues [active] 317936002524 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 317936002525 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 317936002526 active site residue [active] 317936002527 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 317936002528 dimer interface [polypeptide binding]; other site 317936002529 catalytic triad [active] 317936002530 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 317936002531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002532 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002533 dimer interface [polypeptide binding]; other site 317936002534 phosphorylation site [posttranslational modification] 317936002535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002536 ATP binding site [chemical binding]; other site 317936002537 Mg2+ binding site [ion binding]; other site 317936002538 G-X-G motif; other site 317936002539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704 317936002540 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 317936002541 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936002542 HEAT repeats; Region: HEAT_2; pfam13646 317936002543 non-SMC mitotic condensation complex subunit 1; Region: Cnd1; pfam12717 317936002544 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 317936002545 EamA-like transporter family; Region: EamA; pfam00892 317936002546 EamA-like transporter family; Region: EamA; pfam00892 317936002547 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 317936002548 B12 binding site [chemical binding]; other site 317936002549 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 317936002550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 317936002551 FeS/SAM binding site; other site 317936002552 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 317936002553 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 317936002554 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 317936002555 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936002556 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 317936002557 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 317936002558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936002559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936002560 homodimer interface [polypeptide binding]; other site 317936002561 catalytic residue [active] 317936002562 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 317936002563 IHF dimer interface [polypeptide binding]; other site 317936002564 IHF - DNA interface [nucleotide binding]; other site 317936002565 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 317936002566 Amidase; Region: Amidase; pfam01425 317936002567 S-layer homology domain; Region: SLH; pfam00395 317936002568 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 317936002569 Carbohydrate-selective porin, OprB family; Region: OprB; cl17816 317936002570 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 317936002571 amidase; Provisional; Region: PRK09201 317936002572 Amidase; Region: Amidase; cl11426 317936002573 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 317936002574 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 317936002575 active site 317936002576 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936002577 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 317936002578 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 317936002579 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 317936002580 active site 317936002581 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 317936002582 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 317936002583 substrate binding site [chemical binding]; other site 317936002584 ATP binding site [chemical binding]; other site 317936002585 Predicted methyltransferases [General function prediction only]; Region: COG0313 317936002586 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 317936002587 putative SAM binding site [chemical binding]; other site 317936002588 putative homodimer interface [polypeptide binding]; other site 317936002589 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 317936002590 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 317936002591 putative active site [active] 317936002592 catalytic residue [active] 317936002593 twin arginine translocase protein A; Provisional; Region: tatA; PRK14857 317936002594 photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624 317936002595 Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468 317936002596 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 317936002597 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 317936002598 active site 317936002599 catalytic site [active] 317936002600 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 317936002601 OPT oligopeptide transporter protein; Region: OPT; cl14607 317936002602 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 317936002603 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 317936002604 Mg++ binding site [ion binding]; other site 317936002605 putative catalytic motif [active] 317936002606 putative substrate binding site [chemical binding]; other site 317936002607 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 317936002608 PAP_fibrillin; Region: PAP_fibrillin; pfam04755 317936002609 photosystem I subunit IV; Reviewed; Region: psaE; CHL00125 317936002610 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 317936002611 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 317936002612 DNA binding site [nucleotide binding] 317936002613 catalytic residue [active] 317936002614 H2TH interface [polypeptide binding]; other site 317936002615 putative catalytic residues [active] 317936002616 turnover-facilitating residue; other site 317936002617 intercalation triad [nucleotide binding]; other site 317936002618 8OG recognition residue [nucleotide binding]; other site 317936002619 putative reading head residues; other site 317936002620 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 317936002621 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 317936002622 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 317936002623 malate dehydrogenase; Reviewed; Region: PRK06223 317936002624 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 317936002625 NAD(P) binding site [chemical binding]; other site 317936002626 dimer interface [polypeptide binding]; other site 317936002627 tetramer (dimer of dimers) interface [polypeptide binding]; other site 317936002628 substrate binding site [chemical binding]; other site 317936002629 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 317936002630 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936002631 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 317936002632 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 317936002633 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 317936002634 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 317936002635 active site 317936002636 dimer interface [polypeptide binding]; other site 317936002637 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 317936002638 dimer interface [polypeptide binding]; other site 317936002639 active site 317936002640 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 317936002641 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 317936002642 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 317936002643 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 317936002644 TM-ABC transporter signature motif; other site 317936002645 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 317936002646 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 317936002647 Walker A/P-loop; other site 317936002648 ATP binding site [chemical binding]; other site 317936002649 Q-loop/lid; other site 317936002650 ABC transporter signature motif; other site 317936002651 Walker B; other site 317936002652 D-loop; other site 317936002653 H-loop/switch region; other site 317936002654 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 317936002655 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 317936002656 tRNA; other site 317936002657 putative tRNA binding site [nucleotide binding]; other site 317936002658 putative NADP binding site [chemical binding]; other site 317936002659 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 317936002660 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 317936002661 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 317936002662 putative active site [active] 317936002663 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 317936002664 GSH binding site [chemical binding]; other site 317936002665 catalytic residues [active] 317936002666 cytochrome f; Region: petA; CHL00037 317936002667 apocytochrome f; Reviewed; Region: PRK02693 317936002668 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 317936002669 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 317936002670 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 317936002671 cytochrome b subunit interaction site [polypeptide binding]; other site 317936002672 [2Fe-2S] cluster binding site [ion binding]; other site 317936002673 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 317936002674 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936002675 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936002676 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936002677 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 317936002678 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936002679 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936002680 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936002681 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936002682 Phosphotransferase enzyme family; Region: APH; pfam01636 317936002683 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 317936002684 active site 317936002685 ATP binding site [chemical binding]; other site 317936002686 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 317936002687 substrate binding site [chemical binding]; other site 317936002688 Sec-independent translocase component C; Provisional; Region: tatC; CHL00182 317936002689 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936002690 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936002691 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936002692 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 317936002693 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 317936002694 dimerization interface [polypeptide binding]; other site 317936002695 active site 317936002696 metal binding site [ion binding]; metal-binding site 317936002697 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 317936002698 dsRNA binding site [nucleotide binding]; other site 317936002699 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 317936002700 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 317936002701 oligomer interface [polypeptide binding]; other site 317936002702 metal binding site [ion binding]; metal-binding site 317936002703 metal binding site [ion binding]; metal-binding site 317936002704 Cl binding site [ion binding]; other site 317936002705 aspartate ring; other site 317936002706 basic sphincter; other site 317936002707 putative hydrophobic gate; other site 317936002708 periplasmic entrance; other site 317936002709 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 317936002710 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 317936002711 ring oligomerisation interface [polypeptide binding]; other site 317936002712 ATP/Mg binding site [chemical binding]; other site 317936002713 stacking interactions; other site 317936002714 hinge regions; other site 317936002715 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 317936002716 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 317936002717 Mg++ binding site [ion binding]; other site 317936002718 putative catalytic motif [active] 317936002719 substrate binding site [chemical binding]; other site 317936002720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 317936002721 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 317936002722 NAD(P) binding site [chemical binding]; other site 317936002723 homotetramer interface [polypeptide binding]; other site 317936002724 homodimer interface [polypeptide binding]; other site 317936002725 active site 317936002726 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936002727 catalytic residues [active] 317936002728 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 317936002729 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936002730 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 317936002731 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936002732 catalytic residues [active] 317936002733 glutaminase; Provisional; Region: PRK00971 317936002734 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 317936002735 photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056 317936002736 photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199 317936002737 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371 317936002738 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 317936002739 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 317936002740 active site 317936002741 catalytic triad [active] 317936002742 oxyanion hole [active] 317936002743 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 317936002744 hypothetical protein; Provisional; Region: PRK02237 317936002745 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 317936002746 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 317936002747 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 317936002748 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 317936002749 active site 317936002750 dimer interface [polypeptide binding]; other site 317936002751 phosphoribulokinase; Provisional; Region: PRK07429 317936002752 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 317936002753 active site 317936002754 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 317936002755 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 317936002756 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 317936002757 dimerization interface [polypeptide binding]; other site 317936002758 FAD binding pocket [chemical binding]; other site 317936002759 FAD binding motif [chemical binding]; other site 317936002760 catalytic residues [active] 317936002761 NAD binding pocket [chemical binding]; other site 317936002762 phosphate binding motif [ion binding]; other site 317936002763 beta-alpha-beta structure motif; other site 317936002764 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 317936002765 homoserine dehydrogenase; Provisional; Region: PRK06349 317936002766 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 317936002767 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 317936002768 S-layer homology domain; Region: SLH; pfam00395 317936002769 S-layer homology domain; Region: SLH; pfam00395 317936002770 S-layer homology domain; Region: SLH; pfam00395 317936002771 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 317936002772 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 317936002773 Amidinotransferase; Region: Amidinotransf; cl12043 317936002774 Uncharacterized conserved protein [Function unknown]; Region: COG1915 317936002775 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 317936002776 homodimer interface [polypeptide binding]; other site 317936002777 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 317936002778 Peptidase family U32; Region: Peptidase_U32; pfam01136 317936002779 Collagenase; Region: DUF3656; pfam12392 317936002780 Peptidase family U32; Region: Peptidase_U32; cl03113 317936002781 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 317936002782 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936002783 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936002784 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936002785 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 317936002786 O-Antigen ligase; Region: Wzy_C; pfam04932 317936002787 Transcriptional regulator [Transcription]; Region: LysR; COG0583 317936002788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936002789 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 317936002790 dimerization interface [polypeptide binding]; other site 317936002791 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 317936002792 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 317936002793 3-alpha domain; Region: 3-alpha; pfam03475 317936002794 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 317936002795 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 317936002796 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 317936002797 acyl-CoA synthetase; Validated; Region: PRK08162 317936002798 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 317936002799 acyl-activating enzyme (AAE) consensus motif; other site 317936002800 AMP binding site [chemical binding]; other site 317936002801 active site 317936002802 CoA binding site [chemical binding]; other site 317936002803 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936002804 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936002805 HPP family; Region: HPP; pfam04982 317936002806 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936002807 TLC ATP/ADP transporter; Region: TLC; cl03940 317936002808 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936002809 translation initiation factor 3; Provisional; Region: infC; CHL00199 317936002810 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 317936002811 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 317936002812 hydrolase, alpha/beta fold family protein; Region: PLN02824 317936002813 BON domain; Region: BON; cl02771 317936002814 acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100 317936002815 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 317936002816 putative valine binding site [chemical binding]; other site 317936002817 dimer interface [polypeptide binding]; other site 317936002818 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 317936002819 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936002820 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 317936002821 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 317936002822 surface carbohydrate biosynthesis protein, LIC13510 family; Region: O_ant_LIC13510; TIGR04326 317936002823 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 317936002824 Stage II sporulation protein; Region: SpoIID; pfam08486 317936002825 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936002826 AAA domain; Region: AAA_31; pfam13614 317936002827 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936002828 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936002829 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936002830 GAF domain; Region: GAF; pfam01590 317936002831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936002832 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936002833 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936002834 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936002835 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002836 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002837 dimer interface [polypeptide binding]; other site 317936002838 phosphorylation site [posttranslational modification] 317936002839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002840 ATP binding site [chemical binding]; other site 317936002841 Mg2+ binding site [ion binding]; other site 317936002842 G-X-G motif; other site 317936002843 Phage Terminase; Region: Terminase_1; pfam03354 317936002844 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936002845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936002846 S-adenosylmethionine binding site [chemical binding]; other site 317936002847 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 317936002848 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 317936002849 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 317936002850 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 317936002851 nitrogenase reductase; Reviewed; Region: PRK13236 317936002852 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 317936002853 Nucleotide-binding sites [chemical binding]; other site 317936002854 Walker A motif; other site 317936002855 Switch I region of nucleotide binding site; other site 317936002856 Fe4S4 binding sites [ion binding]; other site 317936002857 Switch II region of nucleotide binding site; other site 317936002858 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 317936002859 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 317936002860 FOG: WD40-like repeat [Function unknown]; Region: COG1520 317936002861 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 317936002862 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 317936002863 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936002864 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 317936002865 protein binding site [polypeptide binding]; other site 317936002866 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 317936002867 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 317936002868 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 317936002869 active site 317936002870 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 317936002871 homodecamer interface [polypeptide binding]; other site 317936002872 GTP cyclohydrolase I; Provisional; Region: PLN03044 317936002873 active site 317936002874 putative catalytic site residues [active] 317936002875 zinc binding site [ion binding]; other site 317936002876 GTP-CH-I/GFRP interaction surface; other site 317936002877 short chain dehydrogenase; Provisional; Region: PRK07454 317936002878 classical (c) SDRs; Region: SDR_c; cd05233 317936002879 NAD(P) binding site [chemical binding]; other site 317936002880 active site 317936002881 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 317936002882 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 317936002883 acyl-ACP reductase; Provisional; Region: PRK14982 317936002884 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 317936002885 NAD(P) binding pocket [chemical binding]; other site 317936002886 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 317936002887 dinuclear metal binding motif [ion binding]; other site 317936002888 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 317936002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936002890 dimer interface [polypeptide binding]; other site 317936002891 conserved gate region; other site 317936002892 putative PBP binding loops; other site 317936002893 ABC-ATPase subunit interface; other site 317936002894 proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787 317936002895 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936002896 active site 317936002897 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 317936002898 Domain of unknown function DUF21; Region: DUF21; pfam01595 317936002899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 317936002900 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 317936002901 Transporter associated domain; Region: CorC_HlyC; smart01091 317936002902 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 317936002903 Ligand Binding Site [chemical binding]; other site 317936002904 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936002905 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936002906 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 317936002907 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 317936002908 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 317936002909 Mg binding site [ion binding]; other site 317936002910 nucleotide binding site [chemical binding]; other site 317936002911 putative protofilament interface [polypeptide binding]; other site 317936002912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002914 binding surface 317936002915 TPR motif; other site 317936002916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002919 binding surface 317936002920 TPR motif; other site 317936002921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002922 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002923 binding surface 317936002924 TPR motif; other site 317936002925 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002926 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002927 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936002928 binding surface 317936002929 TPR motif; other site 317936002930 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936002931 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 317936002932 putative active site [active] 317936002933 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 317936002934 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 317936002935 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936002936 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 317936002937 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 317936002938 active site 317936002939 substrate binding site [chemical binding]; other site 317936002940 metal binding site [ion binding]; metal-binding site 317936002941 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 317936002942 active site 317936002943 dimerization interface [polypeptide binding]; other site 317936002944 Domain of unknown function (DUF1817); Region: DUF1817; pfam08847 317936002945 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 317936002946 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 317936002947 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 317936002948 putative active site [active] 317936002949 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 317936002950 substrate binding site; other site 317936002951 dimer interface; other site 317936002952 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 317936002953 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936002954 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936002955 Protein of unknown function (DUF760); Region: DUF760; pfam05542 317936002956 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 317936002957 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936002958 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 317936002959 protein binding site [polypeptide binding]; other site 317936002960 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936002961 GAF domain; Region: GAF_3; pfam13492 317936002962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936002963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936002964 dimer interface [polypeptide binding]; other site 317936002965 phosphorylation site [posttranslational modification] 317936002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002967 ATP binding site [chemical binding]; other site 317936002968 Mg2+ binding site [ion binding]; other site 317936002969 G-X-G motif; other site 317936002970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002971 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002972 putative active site [active] 317936002973 heme pocket [chemical binding]; other site 317936002974 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936002975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002976 putative active site [active] 317936002977 heme pocket [chemical binding]; other site 317936002978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002979 putative active site [active] 317936002980 heme pocket [chemical binding]; other site 317936002981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002982 PAS domain; Region: PAS_9; pfam13426 317936002983 putative active site [active] 317936002984 heme pocket [chemical binding]; other site 317936002985 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936002986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936002987 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936002988 dimer interface [polypeptide binding]; other site 317936002989 phosphorylation site [posttranslational modification] 317936002990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936002991 ATP binding site [chemical binding]; other site 317936002992 Mg2+ binding site [ion binding]; other site 317936002993 G-X-G motif; other site 317936002994 Response regulator receiver domain; Region: Response_reg; pfam00072 317936002995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936002996 active site 317936002997 phosphorylation site [posttranslational modification] 317936002998 intermolecular recognition site; other site 317936002999 dimerization interface [polypeptide binding]; other site 317936003000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003002 active site 317936003003 phosphorylation site [posttranslational modification] 317936003004 intermolecular recognition site; other site 317936003005 Response regulator receiver domain; Region: Response_reg; pfam00072 317936003006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003007 active site 317936003008 phosphorylation site [posttranslational modification] 317936003009 intermolecular recognition site; other site 317936003010 dimerization interface [polypeptide binding]; other site 317936003011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936003013 binding surface 317936003014 TPR motif; other site 317936003015 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003016 binding surface 317936003017 TPR motif; other site 317936003018 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936003019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003020 binding surface 317936003021 TPR motif; other site 317936003022 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936003023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003024 binding surface 317936003025 TPR motif; other site 317936003026 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 317936003027 Prostaglandin dehydrogenases; Region: PGDH; cd05288 317936003028 NAD(P) binding site [chemical binding]; other site 317936003029 substrate binding site [chemical binding]; other site 317936003030 dimer interface [polypeptide binding]; other site 317936003031 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 317936003032 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 317936003033 ABC-ATPase subunit interface; other site 317936003034 dimer interface [polypeptide binding]; other site 317936003035 putative PBP binding regions; other site 317936003036 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 317936003037 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 317936003038 Walker A/P-loop; other site 317936003039 ATP binding site [chemical binding]; other site 317936003040 Q-loop/lid; other site 317936003041 ABC transporter signature motif; other site 317936003042 Walker B; other site 317936003043 D-loop; other site 317936003044 H-loop/switch region; other site 317936003045 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 317936003046 Cadmium resistance transporter; Region: Cad; pfam03596 317936003047 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 317936003048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936003049 dimer interface [polypeptide binding]; other site 317936003050 conserved gate region; other site 317936003051 putative PBP binding loops; other site 317936003052 ABC-ATPase subunit interface; other site 317936003053 phosphodiesterase YaeI; Provisional; Region: PRK11340 317936003054 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 317936003055 putative active site [active] 317936003056 putative metal binding site [ion binding]; other site 317936003057 phosphodiesterase YaeI; Provisional; Region: PRK11340 317936003058 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 317936003059 putative active site [active] 317936003060 putative metal binding site [ion binding]; other site 317936003061 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 317936003062 active site 317936003063 putative homodimer interface [polypeptide binding]; other site 317936003064 SAM binding site [chemical binding]; other site 317936003065 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 317936003066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936003067 S-adenosylmethionine binding site [chemical binding]; other site 317936003068 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 317936003069 putative hexamer interface [polypeptide binding]; other site 317936003070 putative hexagonal pore; other site 317936003071 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 317936003072 Hexamer interface [polypeptide binding]; other site 317936003073 Hexagonal pore residue; other site 317936003074 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003075 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003076 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003077 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003078 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003079 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003080 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003081 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 317936003082 active site clefts [active] 317936003083 zinc binding site [ion binding]; other site 317936003084 dimer interface [polypeptide binding]; other site 317936003085 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 317936003086 active site clefts [active] 317936003087 zinc binding site [ion binding]; other site 317936003088 dimer interface [polypeptide binding]; other site 317936003089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936003090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936003091 active site 317936003092 ATP binding site [chemical binding]; other site 317936003093 substrate binding site [chemical binding]; other site 317936003094 activation loop (A-loop); other site 317936003095 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936003096 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936003097 structural tetrad; other site 317936003098 Filovirus glycoprotein; Region: Filo_glycop; pfam01611 317936003099 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936003100 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 317936003101 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 317936003102 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 317936003103 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 317936003104 Walker A/P-loop; other site 317936003105 ATP binding site [chemical binding]; other site 317936003106 Q-loop/lid; other site 317936003107 ABC transporter signature motif; other site 317936003108 Walker B; other site 317936003109 D-loop; other site 317936003110 H-loop/switch region; other site 317936003111 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 317936003112 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003113 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003114 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936003115 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936003116 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003117 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 317936003118 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 317936003119 ABC-ATPase subunit interface; other site 317936003120 dimer interface [polypeptide binding]; other site 317936003121 putative PBP binding regions; other site 317936003122 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 317936003123 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 317936003124 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 317936003125 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 317936003126 metal binding site [ion binding]; metal-binding site 317936003127 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 317936003128 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936003129 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936003130 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936003131 Protein of unknown function (DUF561); Region: DUF561; pfam04481 317936003132 putative glycosyl transferase; Provisional; Region: PRK10307 317936003133 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 317936003134 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 317936003135 AAA domain; Region: AAA_33; pfam13671 317936003136 ATP-binding site [chemical binding]; other site 317936003137 Gluconate-6-phosphate binding site [chemical binding]; other site 317936003138 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 317936003139 light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810 317936003140 putative NAD(P) binding site [chemical binding]; other site 317936003141 active site 317936003142 Family description; Region: VCBS; pfam13517 317936003143 Family description; Region: VCBS; pfam13517 317936003144 Family description; Region: VCBS; pfam13517 317936003145 Family description; Region: VCBS; pfam13517 317936003146 Family description; Region: VCBS; pfam13517 317936003147 Family description; Region: VCBS; pfam13517 317936003148 proline aminopeptidase P II; Provisional; Region: PRK10879 317936003149 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 317936003150 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 317936003151 active site 317936003152 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 317936003153 PAS domain S-box; Region: sensory_box; TIGR00229 317936003154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936003155 putative active site [active] 317936003156 heme pocket [chemical binding]; other site 317936003157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936003158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936003159 metal binding site [ion binding]; metal-binding site 317936003160 active site 317936003161 I-site; other site 317936003162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936003163 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 317936003164 classical (c) SDRs; Region: SDR_c; cd05233 317936003165 NAD(P) binding site [chemical binding]; other site 317936003166 active site 317936003167 histidine decarboxylase; Provisional; Region: PRK02769 317936003168 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936003169 catalytic residue [active] 317936003170 cell division protein; Validated; Region: ftsH; CHL00176 317936003171 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936003172 Walker A motif; other site 317936003173 ATP binding site [chemical binding]; other site 317936003174 Walker B motif; other site 317936003175 arginine finger; other site 317936003176 Peptidase family M41; Region: Peptidase_M41; pfam01434 317936003177 Predicted flavoprotein [General function prediction only]; Region: COG0431 317936003178 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 317936003179 cell division protein; Validated; Region: ftsH; CHL00176 317936003180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936003181 Walker A motif; other site 317936003182 ATP binding site [chemical binding]; other site 317936003183 Walker B motif; other site 317936003184 arginine finger; other site 317936003185 Peptidase family M41; Region: Peptidase_M41; pfam01434 317936003186 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 317936003187 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 317936003188 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 317936003189 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 317936003190 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 317936003191 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 317936003192 active site 317936003193 intersubunit interface [polypeptide binding]; other site 317936003194 catalytic residue [active] 317936003195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 317936003196 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 317936003197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 317936003198 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 317936003199 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 317936003200 Trehalase; Region: Trehalase; cl17346 317936003201 Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280 317936003202 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 317936003203 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 317936003204 active site 317936003205 catalytic site [active] 317936003206 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 317936003207 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 317936003208 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 317936003209 catalytic site [active] 317936003210 active site 317936003211 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 317936003212 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 317936003213 Domain of unknown function (DUF814); Region: DUF814; pfam05670 317936003214 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936003215 putative active site [active] 317936003216 AMIN domain; Region: AMIN; pfam11741 317936003217 Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796 317936003218 Secretin and TonB N terminus short domain; Region: STN; pfam07660 317936003219 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 317936003220 Type II secretion system (T2SS), protein M subtype b; Region: T2SM_b; pfam10741 317936003221 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 317936003222 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 317936003223 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 317936003224 Cell division protein FtsA; Region: FtsA; cl17206 317936003225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936003226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 317936003227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 317936003228 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 317936003229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936003230 photosystem II protein Y; Reviewed; Region: pbsY; PRK13240 317936003231 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 317936003232 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 317936003233 trimer interface [polypeptide binding]; other site 317936003234 putative metal binding site [ion binding]; other site 317936003235 Protein of unknown function (DUF2396); Region: DUF2396; pfam09654 317936003236 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 317936003237 active site 317936003238 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936003239 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936003240 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936003241 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936003242 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936003243 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936003244 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 317936003245 methionine aminopeptidase; Provisional; Region: PRK08671 317936003246 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 317936003247 active site 317936003248 UV-endonuclease UvdE; Region: UvdE; cl10036 317936003249 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 317936003250 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 317936003251 nucleotide binding site [chemical binding]; other site 317936003252 putative NEF/HSP70 interaction site [polypeptide binding]; other site 317936003253 SBD interface [polypeptide binding]; other site 317936003254 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 317936003255 Domain of unknown function DUF29; Region: DUF29; pfam01724 317936003256 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936003257 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 317936003258 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936003259 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 317936003260 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 317936003261 ABC-ATPase subunit interface; other site 317936003262 dimer interface [polypeptide binding]; other site 317936003263 putative PBP binding regions; other site 317936003264 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 317936003265 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 317936003266 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 317936003267 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 317936003268 intersubunit interface [polypeptide binding]; other site 317936003269 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 317936003270 putative lipid kinase; Reviewed; Region: PRK13057 317936003271 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 317936003272 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 317936003273 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 317936003274 substrate binding site [chemical binding]; other site 317936003275 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 317936003276 substrate binding site [chemical binding]; other site 317936003277 ligand binding site [chemical binding]; other site 317936003278 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936003279 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936003280 active site 317936003281 ATP binding site [chemical binding]; other site 317936003282 substrate binding site [chemical binding]; other site 317936003283 activation loop (A-loop); other site 317936003284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936003285 Methyltransferase domain; Region: Methyltransf_11; pfam08241 317936003286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936003287 active site 317936003288 DNA gyrase subunit A; Validated; Region: PRK05560 317936003289 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 317936003290 CAP-like domain; other site 317936003291 active site 317936003292 primary dimer interface [polypeptide binding]; other site 317936003293 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003294 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003295 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003296 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003297 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003298 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 317936003299 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 317936003300 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 317936003301 putative active site [active] 317936003302 catalytic triad [active] 317936003303 putative dimer interface [polypeptide binding]; other site 317936003304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936003305 putative substrate translocation pore; other site 317936003306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936003307 Repair protein; Region: Repair_PSII; pfam04536 317936003308 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936003309 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936003310 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936003311 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 317936003312 Domain of unknown function (DUF4346); Region: DUF4346; pfam14251 317936003313 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 317936003314 TrkA-N domain; Region: TrkA_N; pfam02254 317936003315 TrkA-C domain; Region: TrkA_C; pfam02080 317936003316 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 317936003317 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 317936003318 tocopherol O-methyltransferase; Region: PLN02244 317936003319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936003320 S-adenosylmethionine binding site [chemical binding]; other site 317936003321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936003322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003323 active site 317936003324 phosphorylation site [posttranslational modification] 317936003325 intermolecular recognition site; other site 317936003326 dimerization interface [polypeptide binding]; other site 317936003327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936003328 DNA binding residues [nucleotide binding] 317936003329 dimerization interface [polypeptide binding]; other site 317936003330 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936003331 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936003332 dimer interface [polypeptide binding]; other site 317936003333 phosphorylation site [posttranslational modification] 317936003334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003335 ATP binding site [chemical binding]; other site 317936003336 Mg2+ binding site [ion binding]; other site 317936003337 G-X-G motif; other site 317936003338 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 317936003339 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 317936003340 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936003341 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936003342 potassium-transporting ATPase subunit C; Provisional; Region: PRK14003 317936003343 TrkA-C domain; Region: TrkA_C; pfam02080 317936003344 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003345 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003346 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003347 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 317936003348 B1 nucleotide binding pocket [chemical binding]; other site 317936003349 B2 nucleotide binding pocket [chemical binding]; other site 317936003350 CAS motifs; other site 317936003351 active site 317936003352 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 317936003353 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 317936003354 aspartate kinase; Validated; Region: PRK09181 317936003355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936003356 non-specific DNA binding site [nucleotide binding]; other site 317936003357 salt bridge; other site 317936003358 sequence-specific DNA binding site [nucleotide binding]; other site 317936003359 aspartate aminotransferase; Provisional; Region: PRK05764 317936003360 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936003361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936003362 homodimer interface [polypeptide binding]; other site 317936003363 catalytic residue [active] 317936003364 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936003365 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936003366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003367 active site 317936003368 phosphorylation site [posttranslational modification] 317936003369 intermolecular recognition site; other site 317936003370 dimerization interface [polypeptide binding]; other site 317936003371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936003372 DNA binding site [nucleotide binding] 317936003373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936003374 Coenzyme A binding pocket [chemical binding]; other site 317936003375 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936003376 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 317936003377 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 317936003378 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 317936003379 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 317936003380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936003381 gamma-glutamyl kinase; Provisional; Region: PRK05429 317936003382 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 317936003383 nucleotide binding site [chemical binding]; other site 317936003384 homotetrameric interface [polypeptide binding]; other site 317936003385 putative phosphate binding site [ion binding]; other site 317936003386 putative allosteric binding site; other site 317936003387 PUA domain; Region: PUA; pfam01472 317936003388 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936003389 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 317936003390 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 317936003391 Walker A/P-loop; other site 317936003392 ATP binding site [chemical binding]; other site 317936003393 Q-loop/lid; other site 317936003394 ABC transporter signature motif; other site 317936003395 Walker B; other site 317936003396 D-loop; other site 317936003397 H-loop/switch region; other site 317936003398 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 317936003399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 317936003400 Walker A/P-loop; other site 317936003401 ATP binding site [chemical binding]; other site 317936003402 Q-loop/lid; other site 317936003403 ABC transporter signature motif; other site 317936003404 Walker B; other site 317936003405 D-loop; other site 317936003406 H-loop/switch region; other site 317936003407 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 317936003408 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 317936003409 protein I interface; other site 317936003410 D2 interface; other site 317936003411 protein T interface; other site 317936003412 chlorophyll binding site; other site 317936003413 beta carotene binding site; other site 317936003414 pheophytin binding site; other site 317936003415 manganese-stabilizing polypeptide interface; other site 317936003416 CP43 interface; other site 317936003417 protein L interface; other site 317936003418 oxygen evolving complex binding site; other site 317936003419 bromide binding site; other site 317936003420 quinone binding site; other site 317936003421 Fe binding site [ion binding]; other site 317936003422 core light harvesting interface; other site 317936003423 cytochrome b559 alpha subunit interface; other site 317936003424 cytochrome c-550 interface; other site 317936003425 protein J interface; other site 317936003426 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936003427 putative active site [active] 317936003428 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936003429 putative active site [active] 317936003430 Uncharacterized conserved protein [Function unknown]; Region: COG4748 317936003431 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 317936003432 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 317936003433 putative active site [active] 317936003434 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 317936003435 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 317936003436 CHAT domain; Region: CHAT; cl17868 317936003437 NACHT domain; Region: NACHT; pfam05729 317936003438 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 317936003439 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 317936003440 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 317936003441 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 317936003442 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 317936003443 Walker A motif; other site 317936003444 ATP binding site [chemical binding]; other site 317936003445 Walker B motif; other site 317936003446 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 317936003447 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 317936003448 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 317936003449 Walker A motif; other site 317936003450 ATP binding site [chemical binding]; other site 317936003451 Walker B motif; other site 317936003452 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 317936003453 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 317936003454 dimer interface [polypeptide binding]; other site 317936003455 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 317936003456 molecular chaperone DnaK; Provisional; Region: PRK13411 317936003457 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 317936003458 nucleotide binding site [chemical binding]; other site 317936003459 NEF interaction site [polypeptide binding]; other site 317936003460 SBD interface [polypeptide binding]; other site 317936003461 chaperone protein DnaJ; Provisional; Region: PRK14293 317936003462 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936003463 HSP70 interaction site [polypeptide binding]; other site 317936003464 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 317936003465 Zn binding sites [ion binding]; other site 317936003466 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 317936003467 dimer interface [polypeptide binding]; other site 317936003468 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 317936003469 CPxP motif; other site 317936003470 GTPase RsgA; Reviewed; Region: PRK12289 317936003471 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 317936003472 RNA binding site [nucleotide binding]; other site 317936003473 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 317936003474 GTPase/Zn-binding domain interface [polypeptide binding]; other site 317936003475 GTP/Mg2+ binding site [chemical binding]; other site 317936003476 G4 box; other site 317936003477 G5 box; other site 317936003478 G1 box; other site 317936003479 Switch I region; other site 317936003480 G2 box; other site 317936003481 G3 box; other site 317936003482 Switch II region; other site 317936003483 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 317936003484 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 317936003485 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 317936003486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936003487 Walker A/P-loop; other site 317936003488 ATP binding site [chemical binding]; other site 317936003489 Q-loop/lid; other site 317936003490 ABC transporter signature motif; other site 317936003491 Walker B; other site 317936003492 D-loop; other site 317936003493 H-loop/switch region; other site 317936003494 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 317936003495 ABC1 family; Region: ABC1; cl17513 317936003496 Haemolytic domain; Region: Haemolytic; cl00506 317936003497 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 317936003498 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 317936003499 Substrate binding site; other site 317936003500 Cupin domain; Region: Cupin_2; cl17218 317936003501 Transcriptional regulator [Transcription]; Region: LytR; COG1316 317936003502 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 317936003503 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003504 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003505 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003506 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003507 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 317936003508 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 317936003509 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 317936003510 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 317936003511 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936003512 motif II; other site 317936003513 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936003514 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936003515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936003516 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 317936003517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936003518 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936003519 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936003520 putative DNA binding site [nucleotide binding]; other site 317936003521 putative Zn2+ binding site [ion binding]; other site 317936003522 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936003523 CHASE2 domain; Region: CHASE2; pfam05226 317936003524 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936003525 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 317936003526 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936003527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936003528 dimer interface [polypeptide binding]; other site 317936003529 phosphorylation site [posttranslational modification] 317936003530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003531 ATP binding site [chemical binding]; other site 317936003532 Mg2+ binding site [ion binding]; other site 317936003533 G-X-G motif; other site 317936003534 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 317936003535 RibD C-terminal domain; Region: RibD_C; cl17279 317936003536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146 317936003537 Protein of unknown function, DUF482; Region: DUF482; pfam04339 317936003538 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936003539 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936003540 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936003541 TPR repeat; Region: TPR_11; pfam13414 317936003542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003543 binding surface 317936003544 TPR motif; other site 317936003545 TPR repeat; Region: TPR_11; pfam13414 317936003546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003547 binding surface 317936003548 TPR motif; other site 317936003549 TPR repeat; Region: TPR_11; pfam13414 317936003550 TPR repeat; Region: TPR_11; pfam13414 317936003551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003552 binding surface 317936003553 TPR motif; other site 317936003554 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 317936003555 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 317936003556 NAD binding site [chemical binding]; other site 317936003557 dimerization interface [polypeptide binding]; other site 317936003558 product binding site; other site 317936003559 substrate binding site [chemical binding]; other site 317936003560 zinc binding site [ion binding]; other site 317936003561 catalytic residues [active] 317936003562 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 317936003563 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 317936003564 active site 317936003565 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 317936003566 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 317936003567 Double zinc ribbon; Region: DZR; pfam12773 317936003568 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 317936003569 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 317936003570 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 317936003571 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 317936003572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003573 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003576 hypothetical protein; Reviewed; Region: PRK12497 317936003577 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 317936003578 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 317936003579 S-layer homology domain; Region: SLH; pfam00395 317936003580 S-layer homology domain; Region: SLH; pfam00395 317936003581 S-layer homology domain; Region: SLH; pfam00395 317936003582 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 317936003583 Response regulator receiver domain; Region: Response_reg; pfam00072 317936003584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003585 active site 317936003586 phosphorylation site [posttranslational modification] 317936003587 intermolecular recognition site; other site 317936003588 dimerization interface [polypeptide binding]; other site 317936003589 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936003590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003591 active site 317936003592 phosphorylation site [posttranslational modification] 317936003593 intermolecular recognition site; other site 317936003594 dimerization interface [polypeptide binding]; other site 317936003595 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 317936003596 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 317936003597 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 317936003598 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936003599 putative active site [active] 317936003600 threonine dehydratase; Reviewed; Region: PRK09224 317936003601 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 317936003602 tetramer interface [polypeptide binding]; other site 317936003603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936003604 catalytic residue [active] 317936003605 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 317936003606 putative Ile/Val binding site [chemical binding]; other site 317936003607 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 317936003608 putative Ile/Val binding site [chemical binding]; other site 317936003609 Double zinc ribbon; Region: DZR; pfam12773 317936003610 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 317936003611 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 317936003612 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 317936003613 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 317936003614 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 317936003615 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 317936003616 putative active site [active] 317936003617 putative dimer interface [polypeptide binding]; other site 317936003618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003619 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936003620 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936003621 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936003622 active site 317936003623 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936003624 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003625 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936003626 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936003627 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 317936003628 active site 317936003629 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 317936003630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003631 putative ADP-binding pocket [chemical binding]; other site 317936003632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936003633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936003634 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936003635 Walker A/P-loop; other site 317936003636 ATP binding site [chemical binding]; other site 317936003637 Q-loop/lid; other site 317936003638 ABC transporter signature motif; other site 317936003639 Walker B; other site 317936003640 D-loop; other site 317936003641 H-loop/switch region; other site 317936003642 Bacterial sugar transferase; Region: Bac_transf; cl00939 317936003643 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936003644 Chain length determinant protein; Region: Wzz; cl15801 317936003645 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 317936003646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003647 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 317936003648 putative ADP-binding pocket [chemical binding]; other site 317936003649 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 317936003650 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936003651 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 317936003652 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 317936003653 guanine deaminase; Provisional; Region: PRK09228 317936003654 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936003655 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936003656 active site 317936003657 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936003658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936003659 active site 317936003660 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 317936003661 extended (e) SDRs; Region: SDR_e; cd08946 317936003662 NAD(P) binding site [chemical binding]; other site 317936003663 active site 317936003664 substrate binding site [chemical binding]; other site 317936003665 Predicted dehydrogenase [General function prediction only]; Region: COG0579 317936003666 hydroxyglutarate oxidase; Provisional; Region: PRK11728 317936003667 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 317936003668 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 317936003669 substrate binding site; other site 317936003670 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 317936003671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936003672 substrate binding site [chemical binding]; other site 317936003673 activation loop (A-loop); other site 317936003674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003675 binding surface 317936003676 TPR repeat; Region: TPR_11; pfam13414 317936003677 TPR motif; other site 317936003678 TPR repeat; Region: TPR_11; pfam13414 317936003679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003680 binding surface 317936003681 TPR motif; other site 317936003682 TPR repeat; Region: TPR_11; pfam13414 317936003683 Protein phosphatase 2C; Region: PP2C_2; pfam13672 317936003684 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 317936003685 metal ion-dependent adhesion site (MIDAS); other site 317936003686 Response regulator receiver domain; Region: Response_reg; pfam00072 317936003687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003688 active site 317936003689 phosphorylation site [posttranslational modification] 317936003690 intermolecular recognition site; other site 317936003691 dimerization interface [polypeptide binding]; other site 317936003692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936003693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936003694 active site 317936003695 catalytic tetrad [active] 317936003696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936003697 active site 317936003698 catalytic tetrad [active] 317936003699 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 317936003700 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 317936003701 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 317936003702 ThiS interaction site; other site 317936003703 putative active site [active] 317936003704 tetramer interface [polypeptide binding]; other site 317936003705 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 317936003706 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 317936003707 active site 317936003708 catalytic residues [active] 317936003709 metal binding site [ion binding]; metal-binding site 317936003710 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 317936003711 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936003712 putative active site [active] 317936003713 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 317936003714 Bacterial Ig-like domain; Region: Big_5; pfam13205 317936003715 TIGR03943 family protein; Region: TIGR03943 317936003716 Predicted permeases [General function prediction only]; Region: COG0701 317936003717 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 317936003718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936003719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003720 ATP binding site [chemical binding]; other site 317936003721 Mg2+ binding site [ion binding]; other site 317936003722 G-X-G motif; other site 317936003723 Caspase domain; Region: Peptidase_C14; pfam00656 317936003724 active site 317936003725 substrate pocket [chemical binding]; other site 317936003726 dimer interface [polypeptide binding]; other site 317936003727 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 317936003728 Uncharacterized subfamily of glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798 317936003729 active site 317936003730 catalytic site [active] 317936003731 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 317936003732 classical (c) SDRs; Region: SDR_c; cd05233 317936003733 NAD(P) binding site [chemical binding]; other site 317936003734 active site 317936003735 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 317936003736 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 317936003737 Short C-terminal domain; Region: SHOCT; pfam09851 317936003738 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 317936003739 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 317936003740 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 317936003741 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 317936003742 Uncharacterized conserved protein [Function unknown]; Region: COG1479 317936003743 Protein of unknown function DUF262; Region: DUF262; pfam03235 317936003744 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936003745 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936003746 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936003747 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 317936003748 pseudouridine synthase; Region: TIGR00093 317936003749 probable active site [active] 317936003750 PAS domain S-box; Region: sensory_box; TIGR00229 317936003751 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936003752 putative active site [active] 317936003753 heme pocket [chemical binding]; other site 317936003754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936003755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936003756 dimer interface [polypeptide binding]; other site 317936003757 phosphorylation site [posttranslational modification] 317936003758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003759 ATP binding site [chemical binding]; other site 317936003760 Mg2+ binding site [ion binding]; other site 317936003761 G-X-G motif; other site 317936003762 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 317936003763 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 317936003764 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 317936003765 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 317936003766 active site 317936003767 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936003768 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936003769 phosphopeptide binding site; other site 317936003770 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936003771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936003772 active site 317936003773 ATP binding site [chemical binding]; other site 317936003774 substrate binding site [chemical binding]; other site 317936003775 activation loop (A-loop); other site 317936003776 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 317936003777 Tetratricopeptide repeat; Region: TPR_6; pfam13174 317936003778 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936003779 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 317936003780 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936003781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936003782 binding surface 317936003783 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936003784 TPR motif; other site 317936003785 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 317936003786 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936003787 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 317936003788 HD domain; Region: HD_4; pfam13328 317936003789 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 317936003790 synthetase active site [active] 317936003791 NTP binding site [chemical binding]; other site 317936003792 metal binding site [ion binding]; metal-binding site 317936003793 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 317936003794 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 317936003795 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 317936003796 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 317936003797 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936003798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936003799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003800 active site 317936003801 phosphorylation site [posttranslational modification] 317936003802 intermolecular recognition site; other site 317936003803 dimerization interface [polypeptide binding]; other site 317936003804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936003805 DNA binding site [nucleotide binding] 317936003806 geranylgeranyl reductase; Region: ChlP; TIGR02028 317936003807 Haemolytic domain; Region: Haemolytic; cl00506 317936003808 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 317936003809 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 317936003810 Walker A/P-loop; other site 317936003811 ATP binding site [chemical binding]; other site 317936003812 Q-loop/lid; other site 317936003813 ABC transporter signature motif; other site 317936003814 Walker B; other site 317936003815 D-loop; other site 317936003816 H-loop/switch region; other site 317936003817 TOBE-like domain; Region: TOBE_3; pfam12857 317936003818 Uncharacterized conserved protein [Function unknown]; Region: COG2128 317936003819 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 317936003820 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 317936003821 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 317936003822 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 317936003823 classical (c) SDRs; Region: SDR_c; cd05233 317936003824 NAD(P) binding site [chemical binding]; other site 317936003825 active site 317936003826 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 317936003827 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 317936003828 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 317936003829 tetramer interface [polypeptide binding]; other site 317936003830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936003831 catalytic residue [active] 317936003832 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 317936003833 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936003834 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936003835 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936003836 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 317936003837 diiron binding motif [ion binding]; other site 317936003838 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 317936003839 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 317936003840 GIY-YIG motif/motif A; other site 317936003841 active site 317936003842 catalytic site [active] 317936003843 putative DNA binding site [nucleotide binding]; other site 317936003844 metal binding site [ion binding]; metal-binding site 317936003845 UvrB/uvrC motif; Region: UVR; pfam02151 317936003846 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 317936003847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936003848 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936003849 active site 317936003850 ATP binding site [chemical binding]; other site 317936003851 substrate binding site [chemical binding]; other site 317936003852 activation loop (A-loop); other site 317936003853 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936003854 AAA ATPase domain; Region: AAA_16; pfam13191 317936003855 Predicted ATPase [General function prediction only]; Region: COG3899 317936003856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936003857 GAF domain; Region: GAF; pfam01590 317936003858 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936003859 cyclase homology domain; Region: CHD; cd07302 317936003860 nucleotidyl binding site; other site 317936003861 metal binding site [ion binding]; metal-binding site 317936003862 dimer interface [polypeptide binding]; other site 317936003863 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 317936003864 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 317936003865 putative active site [active] 317936003866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936003867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936003868 Walker A/P-loop; other site 317936003869 ATP binding site [chemical binding]; other site 317936003870 Q-loop/lid; other site 317936003871 ABC transporter signature motif; other site 317936003872 Walker B; other site 317936003873 D-loop; other site 317936003874 H-loop/switch region; other site 317936003875 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936003876 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 317936003877 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936003878 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 317936003879 Haemolytic domain; Region: Haemolytic; pfam01809 317936003880 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 317936003881 PEP-CTERM motif; Region: VPEP; pfam07589 317936003882 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936003883 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003884 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936003885 anthranilate synthase component I; Provisional; Region: PRK13565 317936003886 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 317936003887 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 317936003888 PsaD; Region: PsaD; pfam02531 317936003889 Domain of unknown function (DUF4415); Region: DUF4415; cl01401 317936003890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929 317936003891 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 317936003892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936003893 GAF domain; Region: GAF; pfam01590 317936003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936003895 dimer interface [polypeptide binding]; other site 317936003896 phosphorylation site [posttranslational modification] 317936003897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003898 ATP binding site [chemical binding]; other site 317936003899 Mg2+ binding site [ion binding]; other site 317936003900 G-X-G motif; other site 317936003901 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 317936003902 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 317936003903 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 317936003904 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 317936003905 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 317936003906 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 317936003907 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 317936003908 active site 317936003909 dimer interface [polypeptide binding]; other site 317936003910 motif 1; other site 317936003911 motif 2; other site 317936003912 motif 3; other site 317936003913 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 317936003914 anticodon binding site; other site 317936003915 XisH protein; Region: XisH; pfam08814 317936003916 XisI protein; Region: XisI; pfam08869 317936003917 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 317936003918 PemK-like protein; Region: PemK; pfam02452 317936003919 homoserine kinase; Provisional; Region: PRK01212 317936003920 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 317936003921 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 317936003922 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 317936003923 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936003924 Protein of unknown function (DUF423); Region: DUF423; pfam04241 317936003925 thymidylate kinase; Validated; Region: tmk; PRK00698 317936003926 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 317936003927 TMP-binding site; other site 317936003928 ATP-binding site [chemical binding]; other site 317936003929 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 317936003930 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936003931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936003932 S-adenosylmethionine binding site [chemical binding]; other site 317936003933 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936003934 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 317936003935 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936003937 S-adenosylmethionine binding site [chemical binding]; other site 317936003938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936003939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936003940 putative substrate translocation pore; other site 317936003941 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 317936003942 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 317936003943 C-terminal domain interface [polypeptide binding]; other site 317936003944 GSH binding site (G-site) [chemical binding]; other site 317936003945 dimer interface [polypeptide binding]; other site 317936003946 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 317936003947 N-terminal domain interface [polypeptide binding]; other site 317936003948 putative dimer interface [polypeptide binding]; other site 317936003949 active site 317936003950 NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370 317936003951 dimer interface [polypeptide binding]; other site 317936003952 FMN binding site [chemical binding]; other site 317936003953 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936003954 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936003955 catalytic residues [active] 317936003956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936003957 dimerization interface [polypeptide binding]; other site 317936003958 putative DNA binding site [nucleotide binding]; other site 317936003959 putative Zn2+ binding site [ion binding]; other site 317936003960 recombination protein RecR; Reviewed; Region: recR; PRK00076 317936003961 RecR protein; Region: RecR; pfam02132 317936003962 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 317936003963 putative active site [active] 317936003964 putative metal-binding site [ion binding]; other site 317936003965 tetramer interface [polypeptide binding]; other site 317936003966 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 317936003967 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936003968 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 317936003969 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936003970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936003971 putative active site [active] 317936003972 heme pocket [chemical binding]; other site 317936003973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936003974 dimer interface [polypeptide binding]; other site 317936003975 phosphorylation site [posttranslational modification] 317936003976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936003977 ATP binding site [chemical binding]; other site 317936003978 Mg2+ binding site [ion binding]; other site 317936003979 G-X-G motif; other site 317936003980 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936003981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936003982 active site 317936003983 phosphorylation site [posttranslational modification] 317936003984 intermolecular recognition site; other site 317936003985 dimerization interface [polypeptide binding]; other site 317936003986 Leucine rich repeat; Region: LRR_8; pfam13855 317936003987 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 317936003988 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 317936003989 Leucine-rich repeats; other site 317936003990 Leucine rich repeat; Region: LRR_8; pfam13855 317936003991 Leucine rich repeat; Region: LRR_8; pfam13855 317936003992 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 317936003993 Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914 317936003994 G1 box; other site 317936003995 GTP/Mg2+ binding site [chemical binding]; other site 317936003996 G2 box; other site 317936003997 Switch I region; other site 317936003998 G3 box; other site 317936003999 Switch II region; other site 317936004000 G4 box; other site 317936004001 G5 box; other site 317936004002 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936004003 oligomeric interface; other site 317936004004 putative active site [active] 317936004005 homodimer interface [polypeptide binding]; other site 317936004006 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 317936004007 Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493 317936004008 photochlorophyllide reductase subunit L; Region: chlL; CHL00072 317936004009 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 317936004010 P-loop; other site 317936004011 Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979 317936004012 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 317936004013 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 317936004014 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 317936004015 photosystem I reaction center subunit X; Reviewed; Region: PRK13214 317936004016 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 317936004017 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 317936004018 active site 317936004019 Zn binding site [ion binding]; other site 317936004020 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 317936004021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936004022 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 317936004023 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 317936004024 active site 317936004025 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 317936004026 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 317936004027 active site 317936004028 (T/H)XGH motif; other site 317936004029 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 317936004030 nudix motif; other site 317936004031 NAD synthetase; Provisional; Region: PRK13981 317936004032 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 317936004033 multimer interface [polypeptide binding]; other site 317936004034 active site 317936004035 catalytic triad [active] 317936004036 protein interface 1 [polypeptide binding]; other site 317936004037 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 317936004038 homodimer interface [polypeptide binding]; other site 317936004039 NAD binding pocket [chemical binding]; other site 317936004040 ATP binding pocket [chemical binding]; other site 317936004041 Mg binding site [ion binding]; other site 317936004042 active-site loop [active] 317936004043 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936004044 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936004045 Walker A/P-loop; other site 317936004046 ATP binding site [chemical binding]; other site 317936004047 Q-loop/lid; other site 317936004048 ABC transporter signature motif; other site 317936004049 Walker B; other site 317936004050 D-loop; other site 317936004051 H-loop/switch region; other site 317936004052 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 317936004053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004054 binding surface 317936004055 TPR motif; other site 317936004056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004057 binding surface 317936004058 TPR motif; other site 317936004059 Uncharacterized conserved protein [Function unknown]; Region: COG0393 317936004060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 317936004061 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936004062 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 317936004063 putative DNA binding site [nucleotide binding]; other site 317936004064 putative Zn2+ binding site [ion binding]; other site 317936004065 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 317936004066 putative ABC transporter; Region: ycf24; CHL00085 317936004067 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 317936004068 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 317936004069 Walker A/P-loop; other site 317936004070 ATP binding site [chemical binding]; other site 317936004071 Q-loop/lid; other site 317936004072 ABC transporter signature motif; other site 317936004073 Walker B; other site 317936004074 D-loop; other site 317936004075 H-loop/switch region; other site 317936004076 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 317936004077 FeS assembly protein SufD; Region: sufD; TIGR01981 317936004078 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 317936004079 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 317936004080 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936004081 catalytic residue [active] 317936004082 Response regulator receiver domain; Region: Response_reg; pfam00072 317936004083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004084 active site 317936004085 phosphorylation site [posttranslational modification] 317936004086 intermolecular recognition site; other site 317936004087 dimerization interface [polypeptide binding]; other site 317936004088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936004089 ATP binding site [chemical binding]; other site 317936004090 G-X-G motif; other site 317936004091 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 317936004092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004093 active site 317936004094 phosphorylation site [posttranslational modification] 317936004095 intermolecular recognition site; other site 317936004096 CheB methylesterase; Region: CheB_methylest; pfam01339 317936004097 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936004098 putative binding surface; other site 317936004099 active site 317936004100 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 317936004101 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 317936004102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936004103 ATP binding site [chemical binding]; other site 317936004104 Mg2+ binding site [ion binding]; other site 317936004105 G-X-G motif; other site 317936004106 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 317936004107 Response regulator receiver domain; Region: Response_reg; pfam00072 317936004108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004109 active site 317936004110 phosphorylation site [posttranslational modification] 317936004111 intermolecular recognition site; other site 317936004112 dimerization interface [polypeptide binding]; other site 317936004113 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 317936004114 CHASE3 domain; Region: CHASE3; pfam05227 317936004115 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 317936004116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936004117 dimerization interface [polypeptide binding]; other site 317936004118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936004119 dimer interface [polypeptide binding]; other site 317936004120 putative CheW interface [polypeptide binding]; other site 317936004121 CHASE3 domain; Region: CHASE3; cl05000 317936004122 HAMP domain; Region: HAMP; pfam00672 317936004123 dimerization interface [polypeptide binding]; other site 317936004124 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 317936004125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936004126 dimer interface [polypeptide binding]; other site 317936004127 putative CheW interface [polypeptide binding]; other site 317936004128 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 317936004129 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 317936004130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004131 binding surface 317936004132 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936004133 TPR motif; other site 317936004134 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 317936004135 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 317936004136 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 317936004137 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 317936004138 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 317936004139 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 317936004140 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 317936004141 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 317936004142 Phasin protein; Region: Phasin_2; cl11491 317936004143 CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711 317936004144 CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159 317936004145 CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709 317936004146 CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712 317936004147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 317936004148 Uncharacterized conserved protein [Function unknown]; Region: COG2442 317936004149 dihydroorotase; Reviewed; Region: PRK09236 317936004150 WYL domain; Region: WYL; pfam13280 317936004151 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313 317936004152 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936004153 active site 317936004154 ATP binding site [chemical binding]; other site 317936004155 substrate binding site [chemical binding]; other site 317936004156 activation loop (A-loop); other site 317936004157 PBP superfamily domain; Region: PBP_like_2; cl17296 317936004158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004159 binding surface 317936004160 TPR motif; other site 317936004161 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936004162 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004163 binding surface 317936004164 TPR motif; other site 317936004165 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004166 binding surface 317936004167 TPR motif; other site 317936004168 CHAT domain; Region: CHAT; cl17868 317936004169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936004170 Walker A motif; other site 317936004171 ATP binding site [chemical binding]; other site 317936004172 Walker B motif; other site 317936004173 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936004174 protein-splicing catalytic site; other site 317936004175 thioester formation/cholesterol transfer; other site 317936004176 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 317936004177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936004178 protein-splicing catalytic site; other site 317936004179 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 317936004180 DNA polymerase III subunit delta'; Validated; Region: PRK08485 317936004181 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 317936004182 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936004183 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 317936004184 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 317936004185 DXD motif; other site 317936004186 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 317936004187 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936004188 DRTGG domain; Region: DRTGG; pfam07085 317936004189 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 317936004190 hydrophobic ligand binding site; other site 317936004191 MAPEG family; Region: MAPEG; cl09190 317936004192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 317936004193 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 317936004194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 317936004195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936004196 substrate binding pocket [chemical binding]; other site 317936004197 membrane-bound complex binding site; other site 317936004198 hinge residues; other site 317936004199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936004200 dimer interface [polypeptide binding]; other site 317936004201 conserved gate region; other site 317936004202 putative PBP binding loops; other site 317936004203 ABC-ATPase subunit interface; other site 317936004204 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 317936004205 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 317936004206 Walker A/P-loop; other site 317936004207 ATP binding site [chemical binding]; other site 317936004208 Q-loop/lid; other site 317936004209 ABC transporter signature motif; other site 317936004210 Walker B; other site 317936004211 D-loop; other site 317936004212 H-loop/switch region; other site 317936004213 Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321 317936004214 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 317936004215 30S subunit binding site; other site 317936004216 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 317936004217 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936004218 catalytic triad [active] 317936004219 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 317936004220 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 317936004221 tellurite resistance protein terB; Region: terB; cd07176 317936004222 putative metal binding site [ion binding]; other site 317936004223 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 317936004224 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 317936004225 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 317936004226 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 317936004227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936004228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936004229 dimer interface [polypeptide binding]; other site 317936004230 phosphorylation site [posttranslational modification] 317936004231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936004232 ATP binding site [chemical binding]; other site 317936004233 Mg2+ binding site [ion binding]; other site 317936004234 G-X-G motif; other site 317936004235 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 317936004236 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 317936004237 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936004238 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936004239 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 317936004240 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 317936004241 tetramer (dimer of dimers) interface [polypeptide binding]; other site 317936004242 active site 317936004243 dimer interface [polypeptide binding]; other site 317936004244 carotene isomerase; Region: carot_isom; TIGR02730 317936004245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 317936004246 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 317936004247 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 317936004248 Walker A/P-loop; other site 317936004249 ATP binding site [chemical binding]; other site 317936004250 Q-loop/lid; other site 317936004251 ABC transporter signature motif; other site 317936004252 Walker B; other site 317936004253 D-loop; other site 317936004254 H-loop/switch region; other site 317936004255 mce related protein; Region: MCE; pfam02470 317936004256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 317936004257 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 317936004258 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 317936004259 active site 317936004260 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 317936004261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936004262 ABC transporter signature motif; other site 317936004263 Walker B; other site 317936004264 D-loop; other site 317936004265 H-loop/switch region; other site 317936004266 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936004267 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936004268 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936004269 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 317936004270 glutaminase A; Region: Gln_ase; TIGR03814 317936004271 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 317936004272 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 317936004273 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 317936004274 Pantoate-beta-alanine ligase; Region: PanC; cd00560 317936004275 active site 317936004276 ATP-binding site [chemical binding]; other site 317936004277 pantoate-binding site; other site 317936004278 HXXH motif; other site 317936004279 AAA domain; Region: AAA_17; pfam13207 317936004280 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 317936004281 CMP-binding site; other site 317936004282 The sites determining sugar specificity; other site 317936004283 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 317936004284 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 317936004285 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 317936004286 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 317936004287 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 317936004288 dimerization interface [polypeptide binding]; other site 317936004289 putative ATP binding site [chemical binding]; other site 317936004290 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 317936004291 PHP domain; Region: PHP; pfam02811 317936004292 active site 317936004293 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 317936004294 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 317936004295 active site 317936004296 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 317936004297 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 317936004298 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 317936004299 beta-phosphoglucomutase; Region: bPGM; TIGR01990 317936004300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936004301 sucrose synthase; Region: sucr_synth; TIGR02470 317936004302 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 317936004303 putative ADP-binding pocket [chemical binding]; other site 317936004304 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936004305 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 317936004306 active site 317936004307 metal binding site [ion binding]; metal-binding site 317936004308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936004309 salt bridge; other site 317936004310 non-specific DNA binding site [nucleotide binding]; other site 317936004311 sequence-specific DNA binding site [nucleotide binding]; other site 317936004312 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 317936004313 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 317936004314 alpha subunit interface [polypeptide binding]; other site 317936004315 TPP binding site [chemical binding]; other site 317936004316 heterodimer interface [polypeptide binding]; other site 317936004317 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 317936004318 protein-export membrane protein SecD; Region: secD; TIGR01129 317936004319 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 317936004320 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 317936004321 Protein export membrane protein; Region: SecD_SecF; pfam02355 317936004322 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 317936004323 putative metal binding site [ion binding]; other site 317936004324 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 317936004325 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936004326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936004327 Coenzyme A binding pocket [chemical binding]; other site 317936004328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936004329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936004330 dimer interface [polypeptide binding]; other site 317936004331 phosphorylation site [posttranslational modification] 317936004332 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 317936004333 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 317936004334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936004335 S-adenosylmethionine binding site [chemical binding]; other site 317936004336 Tic22-like family; Region: Tic22; cl04468 317936004337 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936004338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936004339 Coenzyme A binding pocket [chemical binding]; other site 317936004340 Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479 317936004341 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936004342 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 317936004343 catalytic site [active] 317936004344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 317936004345 Probable transposase; Region: OrfB_IS605; pfam01385 317936004346 Transposase IS200 like; Region: Y1_Tnp; pfam01797 317936004347 UGMP family protein; Validated; Region: PRK09604 317936004348 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 317936004349 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 317936004350 photosystem I reaction center subunit IX; Provisional; Region: PRK02733 317936004351 Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605 317936004352 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 317936004353 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 317936004354 catalytic site [active] 317936004355 G-X2-G-X-G-K; other site 317936004356 hypothetical protein; Provisional; Region: PRK04323 317936004357 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 317936004358 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 317936004359 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 317936004360 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 317936004361 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 317936004362 substrate binding pocket [chemical binding]; other site 317936004363 chain length determination region; other site 317936004364 substrate-Mg2+ binding site; other site 317936004365 catalytic residues [active] 317936004366 aspartate-rich region 1; other site 317936004367 active site lid residues [active] 317936004368 aspartate-rich region 2; other site 317936004369 glutamate racemase; Provisional; Region: PRK00865 317936004370 AMIN domain; Region: AMIN; pfam11741 317936004371 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 317936004372 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 317936004373 active site 317936004374 metal binding site [ion binding]; metal-binding site 317936004375 AMIN domain; Region: AMIN; pfam11741 317936004376 AMIN domain; Region: AMIN; pfam11741 317936004377 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 317936004378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 317936004379 active site 317936004380 metal binding site [ion binding]; metal-binding site 317936004381 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936004382 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 317936004383 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936004384 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936004385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936004386 EVE domain; Region: EVE; pfam01878 317936004387 Uncharacterized conserved protein [Function unknown]; Region: COG2968 317936004388 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 317936004389 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 317936004390 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 317936004391 dimer interface [polypeptide binding]; other site 317936004392 ssDNA binding site [nucleotide binding]; other site 317936004393 tetramer (dimer of dimers) interface [polypeptide binding]; other site 317936004394 rod shape-determining protein MreB; Provisional; Region: PRK13927 317936004395 MreB and similar proteins; Region: MreB_like; cd10225 317936004396 nucleotide binding site [chemical binding]; other site 317936004397 Mg binding site [ion binding]; other site 317936004398 putative protofilament interaction site [polypeptide binding]; other site 317936004399 RodZ interaction site [polypeptide binding]; other site 317936004400 rod shape-determining protein MreC; Provisional; Region: PRK13922 317936004401 rod shape-determining protein MreC; Region: MreC; pfam04085 317936004402 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 317936004403 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 317936004404 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 317936004405 catalytic motif [active] 317936004406 Zn binding site [ion binding]; other site 317936004407 RibD C-terminal domain; Region: RibD_C; cl17279 317936004408 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 317936004409 active site 317936004410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936004411 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 317936004412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936004413 active site 317936004414 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 317936004415 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 317936004416 GTP/Mg2+ binding site [chemical binding]; other site 317936004417 G4 box; other site 317936004418 G5 box; other site 317936004419 G1 box; other site 317936004420 Switch I region; other site 317936004421 G2 box; other site 317936004422 G3 box; other site 317936004423 Switch II region; other site 317936004424 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936004425 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936004426 phosphopeptide binding site; other site 317936004427 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936004428 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936004429 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936004430 cyclase homology domain; Region: CHD; cd07302 317936004431 nucleotidyl binding site; other site 317936004432 metal binding site [ion binding]; metal-binding site 317936004433 dimer interface [polypeptide binding]; other site 317936004434 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 317936004435 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 317936004436 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936004437 dimerization interface [polypeptide binding]; other site 317936004438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936004439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936004440 dimer interface [polypeptide binding]; other site 317936004441 phosphorylation site [posttranslational modification] 317936004442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936004443 ATP binding site [chemical binding]; other site 317936004444 Mg2+ binding site [ion binding]; other site 317936004445 G-X-G motif; other site 317936004446 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936004447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936004448 S-adenosylmethionine binding site [chemical binding]; other site 317936004449 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 317936004450 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936004451 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 317936004452 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936004453 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936004454 active site 317936004455 ATP binding site [chemical binding]; other site 317936004456 substrate binding site [chemical binding]; other site 317936004457 activation loop (A-loop); other site 317936004458 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 317936004459 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 317936004460 dimer interface [polypeptide binding]; other site 317936004461 catalytic triad [active] 317936004462 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 317936004463 G1 box; other site 317936004464 GTP/Mg2+ binding site [chemical binding]; other site 317936004465 G2 box; other site 317936004466 Switch I region; other site 317936004467 G3 box; other site 317936004468 Switch II region; other site 317936004469 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 317936004470 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 317936004471 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 317936004472 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 317936004473 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 317936004474 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 317936004475 active site 317936004476 DNA binding site [nucleotide binding] 317936004477 Int/Topo IB signature motif; other site 317936004478 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945 317936004479 L-aspartate oxidase; Provisional; Region: PRK06175 317936004480 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 317936004481 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 317936004482 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 317936004483 amphipathic channel; other site 317936004484 Asn-Pro-Ala signature motifs; other site 317936004485 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 317936004486 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 317936004487 putative active site [active] 317936004488 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 317936004489 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 317936004490 nucleotide binding site [chemical binding]; other site 317936004491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004492 binding surface 317936004493 TPR motif; other site 317936004494 TPR repeat; Region: TPR_11; pfam13414 317936004495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004496 binding surface 317936004497 TPR motif; other site 317936004498 TPR repeat; Region: TPR_11; pfam13414 317936004499 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936004500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936004501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936004502 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 317936004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936004504 dimer interface [polypeptide binding]; other site 317936004505 conserved gate region; other site 317936004506 ABC-ATPase subunit interface; other site 317936004507 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 317936004508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 317936004509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936004510 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 317936004511 catalytic residues [active] 317936004512 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 317936004513 TPR repeat; Region: TPR_11; pfam13414 317936004514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004515 binding surface 317936004516 TPR motif; other site 317936004517 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 317936004518 CHAT domain; Region: CHAT; pfam12770 317936004519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004521 binding surface 317936004522 TPR motif; other site 317936004523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004525 binding surface 317936004526 TPR motif; other site 317936004527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004529 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004530 binding surface 317936004531 TPR motif; other site 317936004532 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 317936004534 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936004535 putative active site [active] 317936004536 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 317936004537 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936004538 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 317936004539 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936004540 putative binding surface; other site 317936004541 active site 317936004542 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 317936004543 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 317936004544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936004545 ATP binding site [chemical binding]; other site 317936004546 Mg2+ binding site [ion binding]; other site 317936004547 G-X-G motif; other site 317936004548 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 317936004549 Response regulator receiver domain; Region: Response_reg; pfam00072 317936004550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004551 active site 317936004552 phosphorylation site [posttranslational modification] 317936004553 intermolecular recognition site; other site 317936004554 dimerization interface [polypeptide binding]; other site 317936004555 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004556 binding surface 317936004557 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936004558 TPR motif; other site 317936004559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936004560 dimerization interface [polypeptide binding]; other site 317936004561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 317936004562 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 317936004563 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936004564 dimer interface [polypeptide binding]; other site 317936004565 putative CheW interface [polypeptide binding]; other site 317936004566 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 317936004567 Response regulator receiver domain; Region: Response_reg; pfam00072 317936004568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004569 active site 317936004570 phosphorylation site [posttranslational modification] 317936004571 intermolecular recognition site; other site 317936004572 dimerization interface [polypeptide binding]; other site 317936004573 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 317936004574 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936004575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004576 active site 317936004577 phosphorylation site [posttranslational modification] 317936004578 intermolecular recognition site; other site 317936004579 dimerization interface [polypeptide binding]; other site 317936004580 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 317936004581 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 317936004582 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 317936004583 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 317936004584 Ligand Binding Site [chemical binding]; other site 317936004585 cytochrome c biogenesis protein; Region: ccsA; CHL00045 317936004586 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 317936004587 Protein of unknown function (DUF98); Region: DUF98; pfam01947 317936004588 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 317936004589 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 317936004590 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 317936004591 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 317936004592 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936004593 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 317936004594 putative active site pocket [active] 317936004595 dimerization interface [polypeptide binding]; other site 317936004596 putative catalytic residue [active] 317936004597 Predicted integral membrane protein [Function unknown]; Region: COG0762 317936004598 Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596 317936004599 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 317936004600 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 317936004601 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 317936004602 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 317936004603 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 317936004604 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 317936004605 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577 317936004606 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 317936004607 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 317936004608 CAAX protease self-immunity; Region: Abi; pfam02517 317936004609 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 317936004610 UbiA prenyltransferase family; Region: UbiA; pfam01040 317936004611 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 317936004612 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 317936004613 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 317936004614 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 317936004615 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 317936004616 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 317936004617 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 317936004618 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 317936004619 D-pathway; other site 317936004620 Putative ubiquinol binding site [chemical binding]; other site 317936004621 Low-spin heme (heme b) binding site [chemical binding]; other site 317936004622 Putative water exit pathway; other site 317936004623 Binuclear center (heme o3/CuB) [ion binding]; other site 317936004624 K-pathway; other site 317936004625 Putative proton exit pathway; other site 317936004626 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 317936004627 Subunit I/III interface [polypeptide binding]; other site 317936004628 DEAD-like helicases superfamily; Region: DEXDc; smart00487 317936004629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936004630 putative Mg++ binding site [ion binding]; other site 317936004631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936004632 nucleotide binding region [chemical binding]; other site 317936004633 ATP-binding site [chemical binding]; other site 317936004634 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 317936004635 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 317936004636 Active Sites [active] 317936004637 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476 317936004638 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 317936004639 catalytic site [active] 317936004640 putative active site [active] 317936004641 putative substrate binding site [chemical binding]; other site 317936004642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004643 binding surface 317936004644 TPR motif; other site 317936004645 TPR repeat; Region: TPR_11; pfam13414 317936004646 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004647 TPR motif; other site 317936004648 TPR repeat; Region: TPR_11; pfam13414 317936004649 binding surface 317936004650 RDD family; Region: RDD; pfam06271 317936004651 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936004652 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004654 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936004655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004656 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004657 2-dehydropantoate 2-reductase; Provisional; Region: PRK06249 317936004658 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 317936004659 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 317936004660 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 317936004661 Fasciclin domain; Region: Fasciclin; pfam02469 317936004662 aspartate aminotransferase; Provisional; Region: PRK05957 317936004663 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936004664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936004665 homodimer interface [polypeptide binding]; other site 317936004666 catalytic residue [active] 317936004667 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 317936004668 tetratricopeptide repeat protein; Provisional; Region: PRK11788 317936004669 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 317936004670 feedback inhibition sensing region; other site 317936004671 homohexameric interface [polypeptide binding]; other site 317936004672 nucleotide binding site [chemical binding]; other site 317936004673 N-acetyl-L-glutamate binding site [chemical binding]; other site 317936004674 Caspase domain; Region: Peptidase_C14; pfam00656 317936004675 PGAP1-like protein; Region: PGAP1; pfam07819 317936004676 CHAT domain; Region: CHAT; cl17868 317936004677 shikimate kinase; Reviewed; Region: aroK; PRK00131 317936004678 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 317936004679 ADP binding site [chemical binding]; other site 317936004680 magnesium binding site [ion binding]; other site 317936004681 putative shikimate binding site; other site 317936004682 aromatic acid decarboxylase; Validated; Region: PRK05920 317936004683 Flavoprotein; Region: Flavoprotein; pfam02441 317936004684 Exoribonuclease R [Transcription]; Region: VacB; COG0557 317936004685 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 317936004686 RNB domain; Region: RNB; pfam00773 317936004687 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 317936004688 RNA binding site [nucleotide binding]; other site 317936004689 Clp protease; Region: CLP_protease; pfam00574 317936004690 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 317936004691 oligomer interface [polypeptide binding]; other site 317936004692 active site residues [active] 317936004693 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 317936004694 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 317936004695 catalytic residues [active] 317936004696 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 317936004697 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 317936004698 GTP binding site; other site 317936004699 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 317936004700 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 317936004701 intersubunit interface [polypeptide binding]; other site 317936004702 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 317936004703 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 317936004704 Ferritin-like domain; Region: Ferritin; pfam00210 317936004705 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 317936004706 dinuclear metal binding motif [ion binding]; other site 317936004707 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 317936004708 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 317936004709 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 317936004710 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 317936004711 D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173 317936004712 FOG: CBS domain [General function prediction only]; Region: COG0517 317936004713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 317936004714 CP12 domain; Region: CP12; pfam02672 317936004715 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 317936004716 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 317936004717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004718 binding surface 317936004719 TPR motif; other site 317936004720 Uncharacterized conserved protein [Function unknown]; Region: COG2135 317936004721 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936004722 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 317936004723 putative C-terminal domain interface [polypeptide binding]; other site 317936004724 putative GSH binding site (G-site) [chemical binding]; other site 317936004725 putative dimer interface [polypeptide binding]; other site 317936004726 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 317936004727 N-terminal domain interface [polypeptide binding]; other site 317936004728 dimer interface [polypeptide binding]; other site 317936004729 substrate binding pocket (H-site) [chemical binding]; other site 317936004730 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 317936004731 active site 317936004732 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 317936004733 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 317936004734 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 317936004735 RNA binding site [nucleotide binding]; other site 317936004736 active site 317936004737 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 317936004738 Uncharacterized conserved protein [Function unknown]; Region: COG3791 317936004739 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936004740 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 317936004741 HSP70 interaction site [polypeptide binding]; other site 317936004742 Clp protease; Region: CLP_protease; pfam00574 317936004743 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 317936004744 oligomer interface [polypeptide binding]; other site 317936004745 active site residues [active] 317936004746 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 317936004747 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 317936004748 oligomer interface [polypeptide binding]; other site 317936004749 active site residues [active] 317936004750 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 317936004751 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 317936004752 metal ion-dependent adhesion site (MIDAS); other site 317936004753 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 317936004754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 317936004755 metal ion-dependent adhesion site (MIDAS); other site 317936004756 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 317936004757 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 317936004758 alpha-gamma subunit interface [polypeptide binding]; other site 317936004759 beta-gamma subunit interface [polypeptide binding]; other site 317936004760 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 317936004761 gamma-beta subunit interface [polypeptide binding]; other site 317936004762 alpha-beta subunit interface [polypeptide binding]; other site 317936004763 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936004764 AAA domain; Region: AAA_21; pfam13304 317936004765 Walker A/P-loop; other site 317936004766 ATP binding site [chemical binding]; other site 317936004767 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 317936004768 urease subunit alpha; Reviewed; Region: ureC; PRK13207 317936004769 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 317936004770 subunit interactions [polypeptide binding]; other site 317936004771 active site 317936004772 flap region; other site 317936004773 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936004774 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936004775 phosphopeptide binding site; other site 317936004776 Transglycosylase; Region: Transgly; pfam00912 317936004777 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 317936004778 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 317936004779 excinuclease ABC subunit B; Provisional; Region: PRK05298 317936004780 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936004781 ATP binding site [chemical binding]; other site 317936004782 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936004783 nucleotide binding region [chemical binding]; other site 317936004784 ATP-binding site [chemical binding]; other site 317936004785 Ultra-violet resistance protein B; Region: UvrB; pfam12344 317936004786 UvrB/uvrC motif; Region: UVR; pfam02151 317936004787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 317936004788 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 317936004789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936004790 ATP binding site [chemical binding]; other site 317936004791 putative Mg++ binding site [ion binding]; other site 317936004792 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936004793 nucleotide binding region [chemical binding]; other site 317936004794 ATP-binding site [chemical binding]; other site 317936004795 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 317936004796 HRDC domain; Region: HRDC; pfam00570 317936004797 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936004798 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 317936004799 DNA binding residues [nucleotide binding] 317936004800 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936004801 putative active site [active] 317936004802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936004803 binding surface 317936004804 TPR motif; other site 317936004805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004806 TPR motif; other site 317936004807 TPR repeat; Region: TPR_11; pfam13414 317936004808 binding surface 317936004809 TPR repeat; Region: TPR_11; pfam13414 317936004810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004811 binding surface 317936004812 TPR motif; other site 317936004813 TPR repeat; Region: TPR_11; pfam13414 317936004814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936004815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936004816 binding surface 317936004817 TPR motif; other site 317936004818 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 317936004819 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936004820 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 317936004821 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 317936004822 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 317936004823 acyl-activating enzyme (AAE) consensus motif; other site 317936004824 putative AMP binding site [chemical binding]; other site 317936004825 putative active site [active] 317936004826 putative CoA binding site [chemical binding]; other site 317936004827 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 317936004828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936004829 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 317936004830 active site 317936004831 metal binding site [ion binding]; metal-binding site 317936004832 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 317936004833 active site 317936004834 dinuclear metal binding site [ion binding]; other site 317936004835 dimerization interface [polypeptide binding]; other site 317936004836 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 317936004837 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 317936004838 NADP binding site [chemical binding]; other site 317936004839 substrate binding site [chemical binding]; other site 317936004840 active site 317936004841 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 317936004842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936004843 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936004844 NAD(P) binding site [chemical binding]; other site 317936004845 active site 317936004846 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 317936004847 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 317936004848 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 317936004849 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 317936004850 Response regulator receiver domain; Region: Response_reg; pfam00072 317936004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004852 active site 317936004853 phosphorylation site [posttranslational modification] 317936004854 intermolecular recognition site; other site 317936004855 dimerization interface [polypeptide binding]; other site 317936004856 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 317936004857 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004858 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936004859 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004860 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936004861 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 317936004862 metal binding site 2 [ion binding]; metal-binding site 317936004863 putative DNA binding helix; other site 317936004864 metal binding site 1 [ion binding]; metal-binding site 317936004865 dimer interface [polypeptide binding]; other site 317936004866 structural Zn2+ binding site [ion binding]; other site 317936004867 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 317936004868 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 317936004869 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 317936004870 Calx-beta domain; Region: Calx-beta; cl02522 317936004871 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 317936004872 generic binding surface II; other site 317936004873 generic binding surface I; other site 317936004874 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 317936004875 putative active site [active] 317936004876 putative catalytic site [active] 317936004877 putative Mg binding site IVb [ion binding]; other site 317936004878 putative phosphate binding site [ion binding]; other site 317936004879 putative DNA binding site [nucleotide binding]; other site 317936004880 putative Mg binding site IVa [ion binding]; other site 317936004881 Cadherin repeat-like domain; Region: CA_like; cl15786 317936004882 Ca2+ binding site [ion binding]; other site 317936004883 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 317936004884 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936004885 oligomeric interface; other site 317936004886 putative active site [active] 317936004887 homodimer interface [polypeptide binding]; other site 317936004888 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 317936004889 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 317936004890 hydroxyglutarate oxidase; Provisional; Region: PRK11728 317936004891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 317936004892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936004893 Coenzyme A binding pocket [chemical binding]; other site 317936004894 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 317936004895 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936004896 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936004897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936004898 Coenzyme A binding pocket [chemical binding]; other site 317936004899 proton extrusion protein PcxA; Provisional; Region: PRK02507 317936004900 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 317936004901 active site clefts [active] 317936004902 zinc binding site [ion binding]; other site 317936004903 dimer interface [polypeptide binding]; other site 317936004904 Circadian oscillating protein COP23; Region: COP23; pfam14218 317936004905 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936004906 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936004907 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 317936004908 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936004909 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 317936004910 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 317936004911 Uncharacterized conserved protein [Function unknown]; Region: COG1432 317936004912 LabA_like proteins; Region: LabA; cd10911 317936004913 putative metal binding site [ion binding]; other site 317936004914 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 317936004915 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 317936004916 active site 317936004917 HIGH motif; other site 317936004918 KMSKS motif; other site 317936004919 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 317936004920 anticodon binding site; other site 317936004921 tRNA binding surface [nucleotide binding]; other site 317936004922 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 317936004923 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 317936004924 putative acyl-acceptor binding pocket; other site 317936004925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936004926 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936004927 putative active site [active] 317936004928 multifunctional aminopeptidase A; Provisional; Region: PRK00913 317936004929 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 317936004930 interface (dimer of trimers) [polypeptide binding]; other site 317936004931 Substrate-binding/catalytic site; other site 317936004932 Zn-binding sites [ion binding]; other site 317936004933 putative phosphate acyltransferase; Provisional; Region: PRK05331 317936004934 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 317936004935 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 317936004936 dimer interface [polypeptide binding]; other site 317936004937 active site 317936004938 CoA binding pocket [chemical binding]; other site 317936004939 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 317936004940 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 317936004941 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 317936004942 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 317936004943 putative acyl-acceptor binding pocket; other site 317936004944 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936004945 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936004946 Uncharacterized small conserved protein [Function unknown]; Region: COG5626 317936004947 Uncharacterized conserved protein [Function unknown]; Region: COG1434 317936004948 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 317936004949 putative active site [active] 317936004950 Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249 317936004951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936004952 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 317936004953 dimer interface [polypeptide binding]; other site 317936004954 active site 317936004955 metal binding site [ion binding]; metal-binding site 317936004956 glutathione binding site [chemical binding]; other site 317936004957 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 317936004958 Clp amino terminal domain; Region: Clp_N; pfam02861 317936004959 Clp amino terminal domain; Region: Clp_N; pfam02861 317936004960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936004961 Walker A motif; other site 317936004962 ATP binding site [chemical binding]; other site 317936004963 Walker B motif; other site 317936004964 arginine finger; other site 317936004965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936004966 Walker A motif; other site 317936004967 ATP binding site [chemical binding]; other site 317936004968 Walker B motif; other site 317936004969 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 317936004970 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 317936004971 SnoaL-like domain; Region: SnoaL_2; pfam12680 317936004972 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 317936004973 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 317936004974 HEAT repeats; Region: HEAT_2; pfam13646 317936004975 protein binding surface [polypeptide binding]; other site 317936004976 HEAT repeats; Region: HEAT_2; pfam13646 317936004977 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 317936004978 HEAT repeats; Region: HEAT_2; pfam13646 317936004979 protein binding surface [polypeptide binding]; other site 317936004980 HEAT repeats; Region: HEAT_2; pfam13646 317936004981 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 317936004982 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 317936004983 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 317936004984 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 317936004985 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 317936004986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936004987 Walker A motif; other site 317936004988 ATP binding site [chemical binding]; other site 317936004989 Walker B motif; other site 317936004990 arginine finger; other site 317936004991 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 317936004992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936004993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936004994 active site 317936004995 phosphorylation site [posttranslational modification] 317936004996 intermolecular recognition site; other site 317936004997 dimerization interface [polypeptide binding]; other site 317936004998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936004999 DNA binding residues [nucleotide binding] 317936005000 dimerization interface [polypeptide binding]; other site 317936005001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005003 dimer interface [polypeptide binding]; other site 317936005004 phosphorylation site [posttranslational modification] 317936005005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005006 ATP binding site [chemical binding]; other site 317936005007 Mg2+ binding site [ion binding]; other site 317936005008 G-X-G motif; other site 317936005009 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 317936005010 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 317936005011 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 317936005012 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 317936005013 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 317936005014 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 317936005015 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 317936005016 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005018 active site 317936005019 phosphorylation site [posttranslational modification] 317936005020 intermolecular recognition site; other site 317936005021 dimerization interface [polypeptide binding]; other site 317936005022 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005024 active site 317936005025 phosphorylation site [posttranslational modification] 317936005026 intermolecular recognition site; other site 317936005027 dimerization interface [polypeptide binding]; other site 317936005028 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 317936005029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936005030 dimerization interface [polypeptide binding]; other site 317936005031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 317936005032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936005033 dimer interface [polypeptide binding]; other site 317936005034 putative CheW interface [polypeptide binding]; other site 317936005035 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936005036 putative binding surface; other site 317936005037 active site 317936005038 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 317936005039 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 317936005040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005041 ATP binding site [chemical binding]; other site 317936005042 Mg2+ binding site [ion binding]; other site 317936005043 G-X-G motif; other site 317936005044 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 317936005045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005046 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005047 active site 317936005048 phosphorylation site [posttranslational modification] 317936005049 intermolecular recognition site; other site 317936005050 dimerization interface [polypeptide binding]; other site 317936005051 Inward rectifier potassium channel; Region: IRK; pfam01007 317936005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936005053 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936005054 putative substrate translocation pore; other site 317936005055 Biofilm formation and stress response factor; Region: BsmA; cl01794 317936005056 PCI domain; Region: PCI; cl02111 317936005057 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 317936005058 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005059 Phytochrome region; Region: PHY; pfam00360 317936005060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005061 dimer interface [polypeptide binding]; other site 317936005062 phosphorylation site [posttranslational modification] 317936005063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005064 ATP binding site [chemical binding]; other site 317936005065 Mg2+ binding site [ion binding]; other site 317936005066 G-X-G motif; other site 317936005067 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936005068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005069 active site 317936005070 phosphorylation site [posttranslational modification] 317936005071 intermolecular recognition site; other site 317936005072 dimerization interface [polypeptide binding]; other site 317936005073 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005075 active site 317936005076 phosphorylation site [posttranslational modification] 317936005077 intermolecular recognition site; other site 317936005078 dimerization interface [polypeptide binding]; other site 317936005079 GAF domain; Region: GAF; cl17456 317936005080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005082 dimer interface [polypeptide binding]; other site 317936005083 phosphorylation site [posttranslational modification] 317936005084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005085 ATP binding site [chemical binding]; other site 317936005086 Mg2+ binding site [ion binding]; other site 317936005087 G-X-G motif; other site 317936005088 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 317936005089 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 317936005090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005091 binding surface 317936005092 TPR motif; other site 317936005093 TPR repeat; Region: TPR_11; pfam13414 317936005094 TPR repeat; Region: TPR_11; pfam13414 317936005095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005096 binding surface 317936005097 TPR motif; other site 317936005098 TPR repeat; Region: TPR_11; pfam13414 317936005099 TPR repeat; Region: TPR_11; pfam13414 317936005100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005101 binding surface 317936005102 TPR motif; other site 317936005103 TPR repeat; Region: TPR_11; pfam13414 317936005104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936005105 PAS domain; Region: PAS_9; pfam13426 317936005106 putative active site [active] 317936005107 heme pocket [chemical binding]; other site 317936005108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936005109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936005110 metal binding site [ion binding]; metal-binding site 317936005111 active site 317936005112 I-site; other site 317936005113 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936005114 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 317936005115 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 317936005116 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936005117 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936005118 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 317936005119 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 317936005120 putative ADP-binding pocket [chemical binding]; other site 317936005121 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 317936005122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936005124 dimerization interface [polypeptide binding]; other site 317936005125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005126 dimer interface [polypeptide binding]; other site 317936005127 phosphorylation site [posttranslational modification] 317936005128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005129 ATP binding site [chemical binding]; other site 317936005130 Mg2+ binding site [ion binding]; other site 317936005131 G-X-G motif; other site 317936005132 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005134 active site 317936005135 phosphorylation site [posttranslational modification] 317936005136 intermolecular recognition site; other site 317936005137 dimerization interface [polypeptide binding]; other site 317936005138 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 317936005139 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 317936005140 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 317936005141 putative dimer interface [polypeptide binding]; other site 317936005142 putative [2Fe-2S] cluster binding site [ion binding]; other site 317936005143 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936005144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936005145 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 317936005146 Walker A/P-loop; other site 317936005147 ATP binding site [chemical binding]; other site 317936005148 Q-loop/lid; other site 317936005149 ABC transporter signature motif; other site 317936005150 Walker B; other site 317936005151 D-loop; other site 317936005152 H-loop/switch region; other site 317936005153 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 317936005154 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 317936005155 ligand binding site [chemical binding]; other site 317936005156 putative acyl transferase; Provisional; Region: PRK10502 317936005157 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 317936005158 putative trimer interface [polypeptide binding]; other site 317936005159 putative active site [active] 317936005160 putative substrate binding site [chemical binding]; other site 317936005161 putative CoA binding site [chemical binding]; other site 317936005162 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 317936005163 dimer interface [polypeptide binding]; other site 317936005164 substrate binding site [chemical binding]; other site 317936005165 metal binding sites [ion binding]; metal-binding site 317936005166 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 317936005167 tetramerization interface [polypeptide binding]; other site 317936005168 active site 317936005169 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 317936005170 Ferredoxin [Energy production and conversion]; Region: COG1146 317936005171 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 317936005172 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 317936005173 dimer interface [polypeptide binding]; other site 317936005174 motif 1; other site 317936005175 active site 317936005176 motif 2; other site 317936005177 motif 3; other site 317936005178 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936005179 HSP70 interaction site [polypeptide binding]; other site 317936005180 TPR repeat; Region: TPR_11; pfam13414 317936005181 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005182 binding surface 317936005183 TPR motif; other site 317936005184 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005185 GAF domain; Region: GAF; pfam01590 317936005186 PAS domain S-box; Region: sensory_box; TIGR00229 317936005187 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936005188 putative active site [active] 317936005189 heme pocket [chemical binding]; other site 317936005190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005191 dimer interface [polypeptide binding]; other site 317936005192 phosphorylation site [posttranslational modification] 317936005193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005194 ATP binding site [chemical binding]; other site 317936005195 Mg2+ binding site [ion binding]; other site 317936005196 G-X-G motif; other site 317936005197 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005199 active site 317936005200 phosphorylation site [posttranslational modification] 317936005201 intermolecular recognition site; other site 317936005202 dimerization interface [polypeptide binding]; other site 317936005203 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 317936005204 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 317936005205 cobalamin binding residues [chemical binding]; other site 317936005206 putative BtuC binding residues; other site 317936005207 dimer interface [polypeptide binding]; other site 317936005208 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 317936005209 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 317936005210 active site 317936005211 Zn binding site [ion binding]; other site 317936005212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936005213 Coenzyme A binding pocket [chemical binding]; other site 317936005214 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 317936005215 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 317936005216 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 317936005217 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 317936005218 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 317936005219 putative NAD(P) binding site [chemical binding]; other site 317936005220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936005221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 317936005222 DNA binding residues [nucleotide binding] 317936005223 TPR repeat; Region: TPR_11; pfam13414 317936005224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005225 binding surface 317936005226 TPR motif; other site 317936005227 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005228 binding surface 317936005229 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936005230 TPR motif; other site 317936005231 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 317936005232 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 317936005233 multimerization interface [polypeptide binding]; other site 317936005234 RbcX protein; Region: RcbX; pfam02341 317936005235 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040 317936005236 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 317936005237 homodimer interface [polypeptide binding]; other site 317936005238 active site 317936005239 heterodimer interface [polypeptide binding]; other site 317936005240 catalytic residue [active] 317936005241 metal binding site [ion binding]; metal-binding site 317936005242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005243 dimer interface [polypeptide binding]; other site 317936005244 phosphorylation site [posttranslational modification] 317936005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005246 ATP binding site [chemical binding]; other site 317936005247 Mg2+ binding site [ion binding]; other site 317936005248 G-X-G motif; other site 317936005249 Uncharacterized conserved protein [Function unknown]; Region: COG3287 317936005250 FIST N domain; Region: FIST; pfam08495 317936005251 FIST C domain; Region: FIST_C; pfam10442 317936005252 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 317936005253 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 317936005254 oligomerization interface [polypeptide binding]; other site 317936005255 active site 317936005256 metal binding site [ion binding]; metal-binding site 317936005257 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 317936005258 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 317936005259 Catalytic site [active] 317936005260 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 317936005261 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 317936005262 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 317936005263 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 317936005264 substrate binding pocket [chemical binding]; other site 317936005265 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 317936005266 B12 binding site [chemical binding]; other site 317936005267 cobalt ligand [ion binding]; other site 317936005268 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 317936005269 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 317936005270 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 317936005271 putative active site [active] 317936005272 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 317936005273 Leucine rich repeat; Region: LRR_8; pfam13855 317936005274 Leucine rich repeat; Region: LRR_8; pfam13855 317936005275 Leucine rich repeat; Region: LRR_8; pfam13855 317936005276 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936005277 catalytic residues [active] 317936005278 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 317936005279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936005280 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936005281 active site 317936005282 metal binding site [ion binding]; metal-binding site 317936005283 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936005284 putative lipid kinase; Reviewed; Region: PRK00861 317936005285 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 317936005286 Phytochelatin synthase; Region: Phytochelatin; pfam05023 317936005287 YciI-like protein; Reviewed; Region: PRK12864 317936005288 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 317936005289 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 317936005290 putative tRNA-binding site [nucleotide binding]; other site 317936005291 B3/4 domain; Region: B3_4; pfam03483 317936005292 tRNA synthetase B5 domain; Region: B5; smart00874 317936005293 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 317936005294 dimer interface [polypeptide binding]; other site 317936005295 motif 1; other site 317936005296 motif 3; other site 317936005297 motif 2; other site 317936005298 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 317936005299 elongation factor G; Reviewed; Region: PRK00007 317936005300 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 317936005301 G1 box; other site 317936005302 putative GEF interaction site [polypeptide binding]; other site 317936005303 GTP/Mg2+ binding site [chemical binding]; other site 317936005304 Switch I region; other site 317936005305 G2 box; other site 317936005306 G3 box; other site 317936005307 Switch II region; other site 317936005308 G4 box; other site 317936005309 G5 box; other site 317936005310 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 317936005311 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 317936005312 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 317936005313 bile acid transporter; Region: bass; TIGR00841 317936005314 Sodium Bile acid symporter family; Region: SBF; pfam01758 317936005315 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936005316 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936005317 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936005318 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936005319 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 317936005320 catalytic triad [active] 317936005321 putative active site [active] 317936005322 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 317936005323 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 317936005324 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 317936005325 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 317936005326 [2Fe-2S] cluster binding site [ion binding]; other site 317936005327 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 317936005328 hydrophobic ligand binding site; other site 317936005329 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936005330 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936005331 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936005332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936005333 Coenzyme A binding pocket [chemical binding]; other site 317936005334 Protein of unknown function (DUF1838); Region: DUF1838; pfam08894 317936005335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936005336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936005337 metal binding site [ion binding]; metal-binding site 317936005338 active site 317936005339 I-site; other site 317936005340 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 317936005341 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 317936005342 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 317936005343 Predicted permeases [General function prediction only]; Region: COG0679 317936005344 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 317936005345 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936005346 active site 317936005347 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 317936005348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936005349 putative substrate translocation pore; other site 317936005350 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 317936005351 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 317936005352 putative active site [active] 317936005353 putative dimer interface [polypeptide binding]; other site 317936005354 NurA nuclease; Region: NurA; smart00933 317936005355 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 317936005356 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 317936005357 putative catalytic residues [active] 317936005358 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 317936005359 Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059 317936005360 calcium binding site 1 [ion binding]; other site 317936005361 active site 317936005362 catalytic triad [active] 317936005363 calcium binding site 2 [ion binding]; other site 317936005364 calcium binding site 3 [ion binding]; other site 317936005365 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 317936005366 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 317936005367 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 317936005368 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936005369 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936005370 active site 317936005371 ATP binding site [chemical binding]; other site 317936005372 substrate binding site [chemical binding]; other site 317936005373 activation loop (A-loop); other site 317936005374 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 317936005375 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 317936005376 putative ligand binding site [chemical binding]; other site 317936005377 ATP synthase I chain; Region: ATP_synt_I; pfam03899 317936005378 ATP synthase CF0 A subunit; Region: atpI; CHL00046 317936005379 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 317936005380 F0F1 ATP synthase subunit C; Validated; Region: PRK07354 317936005381 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 317936005382 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 317936005383 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 317936005384 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 317936005385 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 317936005386 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 317936005387 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 317936005388 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 317936005389 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 317936005390 beta subunit interaction interface [polypeptide binding]; other site 317936005391 Walker A motif; other site 317936005392 ATP binding site [chemical binding]; other site 317936005393 Walker B motif; other site 317936005394 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 317936005395 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 317936005396 core domain interface [polypeptide binding]; other site 317936005397 delta subunit interface [polypeptide binding]; other site 317936005398 epsilon subunit interface [polypeptide binding]; other site 317936005399 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 317936005400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936005401 Coenzyme A binding pocket [chemical binding]; other site 317936005402 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 317936005403 nitrilase; Region: PLN02798 317936005404 putative active site [active] 317936005405 catalytic triad [active] 317936005406 dimer interface [polypeptide binding]; other site 317936005407 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936005408 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936005409 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936005410 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 317936005411 GTP-binding protein YchF; Reviewed; Region: PRK09601 317936005412 YchF GTPase; Region: YchF; cd01900 317936005413 G1 box; other site 317936005414 GTP/Mg2+ binding site [chemical binding]; other site 317936005415 Switch I region; other site 317936005416 G2 box; other site 317936005417 Switch II region; other site 317936005418 G3 box; other site 317936005419 G4 box; other site 317936005420 G5 box; other site 317936005421 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 317936005422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936005423 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936005424 active site 317936005425 ATP binding site [chemical binding]; other site 317936005426 substrate binding site [chemical binding]; other site 317936005427 activation loop (A-loop); other site 317936005428 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 317936005429 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005431 dimer interface [polypeptide binding]; other site 317936005432 phosphorylation site [posttranslational modification] 317936005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005434 ATP binding site [chemical binding]; other site 317936005435 Mg2+ binding site [ion binding]; other site 317936005436 G-X-G motif; other site 317936005437 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 317936005438 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 317936005439 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 317936005440 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 317936005441 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 317936005442 catalytic triad [active] 317936005443 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 317936005444 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936005445 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 317936005446 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 317936005447 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 317936005448 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 317936005449 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 317936005450 active site 317936005451 Substrate binding site; other site 317936005452 Mg++ binding site; other site 317936005453 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 317936005454 putative CoA binding site [chemical binding]; other site 317936005455 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 317936005456 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 317936005457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 317936005458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936005459 Coenzyme A binding pocket [chemical binding]; other site 317936005460 Homeodomain-like domain; Region: HTH_23; pfam13384 317936005461 Winged helix-turn helix; Region: HTH_29; pfam13551 317936005462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936005463 S-adenosylmethionine binding site [chemical binding]; other site 317936005464 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 317936005465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 317936005466 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 317936005467 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 317936005468 domain interfaces; other site 317936005469 active site 317936005470 glycogen synthase; Provisional; Region: glgA; PRK00654 317936005471 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 317936005472 ADP-binding pocket [chemical binding]; other site 317936005473 homodimer interface [polypeptide binding]; other site 317936005474 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936005475 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936005476 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 317936005477 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 317936005478 active site 317936005479 homodimer interface [polypeptide binding]; other site 317936005480 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 317936005481 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 317936005482 Walker A motif; other site 317936005483 ATP binding site [chemical binding]; other site 317936005484 Walker B motif; other site 317936005485 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 317936005486 tetramer interface [polypeptide binding]; other site 317936005487 dimer interface [polypeptide binding]; other site 317936005488 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 317936005489 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 317936005490 active site 317936005491 Zn binding site [ion binding]; other site 317936005492 Uncharacterized conserved protein [Function unknown]; Region: COG2912 317936005493 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 317936005494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936005495 binding surface 317936005496 TPR motif; other site 317936005497 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936005498 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 317936005499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936005500 S-adenosylmethionine binding site [chemical binding]; other site 317936005501 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 317936005502 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 317936005503 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 317936005504 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 317936005505 active site 317936005506 SAM binding site [chemical binding]; other site 317936005507 homodimer interface [polypeptide binding]; other site 317936005508 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 317936005509 active site 317936005510 Calx-beta domain; Region: Calx-beta; cl02522 317936005511 Calx-beta domain; Region: Calx-beta; pfam03160 317936005512 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936005513 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936005514 structural tetrad; other site 317936005515 PQQ-like domain; Region: PQQ_2; pfam13360 317936005516 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 317936005517 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 317936005518 acyl-activating enzyme (AAE) consensus motif; other site 317936005519 AMP binding site [chemical binding]; other site 317936005520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936005521 thioester reductase domain; Region: Thioester-redct; TIGR01746 317936005522 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 317936005523 putative NAD(P) binding site [chemical binding]; other site 317936005524 active site 317936005525 putative substrate binding site [chemical binding]; other site 317936005526 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936005527 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936005528 active site 317936005529 ATP binding site [chemical binding]; other site 317936005530 substrate binding site [chemical binding]; other site 317936005531 activation loop (A-loop); other site 317936005532 AAA ATPase domain; Region: AAA_16; pfam13191 317936005533 Predicted ATPase [General function prediction only]; Region: COG3899 317936005534 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005535 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005538 ATP binding site [chemical binding]; other site 317936005539 Mg2+ binding site [ion binding]; other site 317936005540 G-X-G motif; other site 317936005541 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 317936005542 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 317936005543 Malic enzyme, N-terminal domain; Region: malic; pfam00390 317936005544 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 317936005545 putative NAD(P) binding site [chemical binding]; other site 317936005546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936005547 metal binding site [ion binding]; metal-binding site 317936005548 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 317936005549 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936005550 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936005551 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396 317936005552 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 317936005553 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 317936005554 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 317936005555 16S/18S rRNA binding site [nucleotide binding]; other site 317936005556 S13e-L30e interaction site [polypeptide binding]; other site 317936005557 25S rRNA binding site [nucleotide binding]; other site 317936005558 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 317936005559 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 317936005560 heterotetramer interface [polypeptide binding]; other site 317936005561 active site pocket [active] 317936005562 cleavage site 317936005563 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 317936005564 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 317936005565 GatB domain; Region: GatB_Yqey; pfam02637 317936005566 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 317936005567 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936005568 oligomeric interface; other site 317936005569 putative active site [active] 317936005570 homodimer interface [polypeptide binding]; other site 317936005571 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 317936005572 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936005573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936005574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936005575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936005576 TPR repeat; Region: TPR_11; pfam13414 317936005577 TPR motif; other site 317936005578 binding surface 317936005579 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 317936005580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936005581 Coenzyme A binding pocket [chemical binding]; other site 317936005582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936005583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936005584 S-adenosylmethionine binding site [chemical binding]; other site 317936005585 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 317936005586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936005587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936005588 homodimer interface [polypeptide binding]; other site 317936005589 catalytic residue [active] 317936005590 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005591 binding surface 317936005592 TPR motif; other site 317936005593 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005594 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005597 binding surface 317936005598 TPR motif; other site 317936005599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005601 binding surface 317936005602 TPR motif; other site 317936005603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005606 binding surface 317936005607 TPR motif; other site 317936005608 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005609 CHAT domain; Region: CHAT; pfam12770 317936005610 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 317936005611 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936005612 dimerization interface [polypeptide binding]; other site 317936005613 putative DNA binding site [nucleotide binding]; other site 317936005614 putative Zn2+ binding site [ion binding]; other site 317936005615 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 317936005616 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 317936005617 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 317936005618 hydrophobic ligand binding site; other site 317936005619 Pheophorbide a oxygenase; Region: PaO; pfam08417 317936005620 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 317936005621 MltA specific insert domain; Region: MltA; pfam03562 317936005622 3D domain; Region: 3D; pfam06725 317936005623 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936005624 putative active site [active] 317936005625 Domain of unknown function DUF39; Region: DUF39; pfam01837 317936005626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005627 TPR motif; other site 317936005628 binding surface 317936005629 TPR repeat; Region: TPR_11; pfam13414 317936005630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005631 TPR motif; other site 317936005632 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936005633 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936005634 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936005635 XisI protein; Region: XisI; pfam08869 317936005636 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 317936005637 PRC-barrel domain; Region: PRC; pfam05239 317936005638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 317936005639 PRC-barrel domain; Region: PRC; pfam05239 317936005640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861 317936005641 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 317936005642 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 317936005643 Walker A/P-loop; other site 317936005644 ATP binding site [chemical binding]; other site 317936005645 Q-loop/lid; other site 317936005646 ABC transporter signature motif; other site 317936005647 Walker B; other site 317936005648 D-loop; other site 317936005649 H-loop/switch region; other site 317936005650 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 317936005651 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 317936005652 Phytochelatin synthase; Region: Phytochelatin; pfam05023 317936005653 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 317936005654 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 317936005655 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293 317936005656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936005657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936005658 active site 317936005659 catalytic tetrad [active] 317936005660 PRC-barrel domain; Region: PRC; pfam05239 317936005661 PRC-barrel domain; Region: PRC; pfam05239 317936005662 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 317936005663 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 317936005664 Walker A/P-loop; other site 317936005665 ATP binding site [chemical binding]; other site 317936005666 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 317936005667 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 317936005668 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 317936005669 ABC transporter signature motif; other site 317936005670 Walker B; other site 317936005671 D-loop; other site 317936005672 H-loop/switch region; other site 317936005673 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 317936005674 HEAT repeats; Region: HEAT_2; pfam13646 317936005675 protein binding surface [polypeptide binding]; other site 317936005676 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936005677 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936005678 active site 317936005679 ATP binding site [chemical binding]; other site 317936005680 substrate binding site [chemical binding]; other site 317936005681 activation loop (A-loop); other site 317936005682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005683 binding surface 317936005684 TPR motif; other site 317936005685 TPR repeat; Region: TPR_11; pfam13414 317936005686 TPR repeat; Region: TPR_11; pfam13414 317936005687 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005688 binding surface 317936005689 TPR motif; other site 317936005690 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936005691 aspartate kinase; Provisional; Region: PRK07431 317936005692 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 317936005693 putative nucleotide binding site [chemical binding]; other site 317936005694 putative catalytic residues [active] 317936005695 putative Mg ion binding site [ion binding]; other site 317936005696 putative aspartate binding site [chemical binding]; other site 317936005697 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 317936005698 putative allosteric regulatory site; other site 317936005699 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 317936005700 putative allosteric regulatory residue; other site 317936005701 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 317936005702 putative allosteric regulatory site; other site 317936005703 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 317936005704 putative allosteric regulatory residue; other site 317936005705 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 317936005706 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 317936005707 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936005708 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 317936005709 anti sigma factor interaction site; other site 317936005710 regulatory phosphorylation site [posttranslational modification]; other site 317936005711 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 317936005712 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 317936005713 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 317936005714 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 317936005715 chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994 317936005716 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 317936005717 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 317936005718 dimer interface [polypeptide binding]; other site 317936005719 active site 317936005720 glycine-pyridoxal phosphate binding site [chemical binding]; other site 317936005721 folate binding site [chemical binding]; other site 317936005722 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 317936005723 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 317936005724 Mg++ binding site [ion binding]; other site 317936005725 putative catalytic motif [active] 317936005726 substrate binding site [chemical binding]; other site 317936005727 competence damage-inducible protein A; Provisional; Region: PRK00549 317936005728 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 317936005729 putative MPT binding site; other site 317936005730 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 317936005731 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 317936005732 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 317936005733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005734 putative acyl transferase; Provisional; Region: PRK10502 317936005735 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 317936005736 putative trimer interface [polypeptide binding]; other site 317936005737 putative active site [active] 317936005738 putative substrate binding site [chemical binding]; other site 317936005739 putative CoA binding site [chemical binding]; other site 317936005740 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936005741 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 317936005742 putative metal binding site; other site 317936005743 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936005744 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936005745 active site 317936005746 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 317936005747 homotrimer interface [polypeptide binding]; other site 317936005748 Walker A motif; other site 317936005749 GTP binding site [chemical binding]; other site 317936005750 Walker B motif; other site 317936005751 ribonuclease Z; Region: RNase_Z; TIGR02651 317936005752 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 317936005753 Acyltransferase family; Region: Acyl_transf_3; pfam01757 317936005754 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 317936005755 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 317936005756 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 317936005757 CoA binding domain; Region: CoA_binding; smart00881 317936005758 CoA-ligase; Region: Ligase_CoA; pfam00549 317936005759 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936005760 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936005761 ligand binding site [chemical binding]; other site 317936005762 flexible hinge region; other site 317936005763 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 317936005764 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 317936005765 ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020 317936005766 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307 317936005767 putative multimerization interface [polypeptide binding]; other site 317936005768 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 317936005769 active site 317936005770 catalytic triad [active] 317936005771 oxyanion hole [active] 317936005772 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 317936005773 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 317936005774 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 317936005775 putative substrate binding site [chemical binding]; other site 317936005776 putative ATP binding site [chemical binding]; other site 317936005777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936005778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936005779 DNA binding residues [nucleotide binding] 317936005780 dimerization interface [polypeptide binding]; other site 317936005781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936005782 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936005783 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936005784 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936005785 active site 317936005786 ATP binding site [chemical binding]; other site 317936005787 substrate binding site [chemical binding]; other site 317936005788 activation loop (A-loop); other site 317936005789 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936005790 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 317936005791 putative metal binding site; other site 317936005792 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005793 binding surface 317936005794 TPR motif; other site 317936005795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005796 TPR repeat; Region: TPR_11; pfam13414 317936005797 binding surface 317936005798 TPR motif; other site 317936005799 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005800 binding surface 317936005801 TPR repeat; Region: TPR_11; pfam13414 317936005802 TPR motif; other site 317936005803 TPR repeat; Region: TPR_11; pfam13414 317936005804 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 317936005805 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 317936005806 P loop; other site 317936005807 Nucleotide binding site [chemical binding]; other site 317936005808 DTAP/Switch II; other site 317936005809 Switch I; other site 317936005810 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 317936005811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005812 GAF domain; Region: GAF; pfam01590 317936005813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005814 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005815 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005817 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005818 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005819 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005821 dimer interface [polypeptide binding]; other site 317936005822 phosphorylation site [posttranslational modification] 317936005823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005824 ATP binding site [chemical binding]; other site 317936005825 Mg2+ binding site [ion binding]; other site 317936005826 G-X-G motif; other site 317936005827 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 317936005828 active site 317936005829 DNA binding site [nucleotide binding] 317936005830 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 317936005831 hypothetical protein; Reviewed; Region: PRK09588 317936005832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005834 binding surface 317936005835 TPR motif; other site 317936005836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005837 CHAT domain; Region: CHAT; pfam12770 317936005838 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 317936005839 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936005840 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936005841 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 317936005842 S-layer homology domain; Region: SLH; pfam00395 317936005843 S-layer homology domain; Region: SLH; pfam00395 317936005844 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936005845 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 317936005846 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 317936005847 Walker A/P-loop; other site 317936005848 ATP binding site [chemical binding]; other site 317936005849 Q-loop/lid; other site 317936005850 ABC transporter signature motif; other site 317936005851 Walker B; other site 317936005852 D-loop; other site 317936005853 H-loop/switch region; other site 317936005854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 317936005855 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 317936005856 Walker A/P-loop; other site 317936005857 ATP binding site [chemical binding]; other site 317936005858 Q-loop/lid; other site 317936005859 ABC transporter signature motif; other site 317936005860 Walker B; other site 317936005861 D-loop; other site 317936005862 H-loop/switch region; other site 317936005863 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 317936005864 NMT1-like family; Region: NMT1_2; pfam13379 317936005865 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 317936005866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936005867 dimer interface [polypeptide binding]; other site 317936005868 conserved gate region; other site 317936005869 putative PBP binding loops; other site 317936005870 ABC-ATPase subunit interface; other site 317936005871 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 317936005872 NMT1-like family; Region: NMT1_2; pfam13379 317936005873 hypothetical protein; Validated; Region: PRK00029 317936005874 Uncharacterized conserved protein [Function unknown]; Region: COG0397 317936005875 CHASE domain; Region: CHASE; cl01369 317936005876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936005877 PAS fold; Region: PAS_3; pfam08447 317936005878 putative active site [active] 317936005879 heme pocket [chemical binding]; other site 317936005880 PAS domain; Region: PAS_9; pfam13426 317936005881 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936005882 putative active site [active] 317936005883 heme pocket [chemical binding]; other site 317936005884 PAS domain S-box; Region: sensory_box; TIGR00229 317936005885 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936005886 putative active site [active] 317936005887 heme pocket [chemical binding]; other site 317936005888 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936005889 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936005890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005891 dimer interface [polypeptide binding]; other site 317936005892 phosphorylation site [posttranslational modification] 317936005893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005894 ATP binding site [chemical binding]; other site 317936005895 Mg2+ binding site [ion binding]; other site 317936005896 G-X-G motif; other site 317936005897 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005899 active site 317936005900 phosphorylation site [posttranslational modification] 317936005901 intermolecular recognition site; other site 317936005902 dimerization interface [polypeptide binding]; other site 317936005903 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936005904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005905 active site 317936005906 phosphorylation site [posttranslational modification] 317936005907 intermolecular recognition site; other site 317936005908 dimerization interface [polypeptide binding]; other site 317936005909 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936005910 putative binding surface; other site 317936005911 active site 317936005912 Response regulator receiver domain; Region: Response_reg; pfam00072 317936005913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005914 active site 317936005915 phosphorylation site [posttranslational modification] 317936005916 intermolecular recognition site; other site 317936005917 dimerization interface [polypeptide binding]; other site 317936005918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936005919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936005920 metal binding site [ion binding]; metal-binding site 317936005921 active site 317936005922 I-site; other site 317936005923 Predicted kinase [General function prediction only]; Region: COG4240 317936005924 active site 317936005925 Protein of unknown function (DUF565); Region: DUF565; pfam04483 317936005926 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 317936005927 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936005928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936005929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936005930 dimer interface [polypeptide binding]; other site 317936005931 phosphorylation site [posttranslational modification] 317936005932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936005933 ATP binding site [chemical binding]; other site 317936005934 Mg2+ binding site [ion binding]; other site 317936005935 G-X-G motif; other site 317936005936 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936005937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936005938 active site 317936005939 phosphorylation site [posttranslational modification] 317936005940 intermolecular recognition site; other site 317936005941 dimerization interface [polypeptide binding]; other site 317936005942 KaiA domain; Region: KaiA; pfam07688 317936005943 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 317936005944 tetramer interface [polypeptide binding]; other site 317936005945 dimer interface [polypeptide binding]; other site 317936005946 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 317936005947 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 317936005948 Walker A motif; other site 317936005949 ATP binding site [chemical binding]; other site 317936005950 Walker B motif; other site 317936005951 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 317936005952 ATP binding site [chemical binding]; other site 317936005953 Walker B motif; other site 317936005954 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 317936005955 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 317936005956 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 317936005957 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936005958 RNA binding surface [nucleotide binding]; other site 317936005959 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 317936005960 active site 317936005961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936005962 binding surface 317936005963 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005964 TPR motif; other site 317936005965 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005966 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936005967 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 317936005968 AAA ATPase domain; Region: AAA_16; pfam13191 317936005969 AAA domain; Region: AAA_22; pfam13401 317936005970 Iguana/Dzip1-like DAZ-interacting protein N-terminal; Region: Dzip-like_N; pfam13815 317936005971 WD domain, G-beta repeat; Region: WD40; pfam00400 317936005972 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936005973 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936005974 structural tetrad; other site 317936005975 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936005976 structural tetrad; other site 317936005977 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936005978 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 317936005979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936005980 binding surface 317936005981 TPR motif; other site 317936005982 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 317936005983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 317936005984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 317936005985 catalytic residue [active] 317936005986 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 317936005987 B12 binding site [chemical binding]; other site 317936005988 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 317936005989 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936005990 FeS/SAM binding site; other site 317936005991 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 317936005992 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 317936005993 dimerization interface [polypeptide binding]; other site 317936005994 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 317936005995 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 317936005996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936005997 light-harvesting-like protein 3; Provisional; Region: PLN00014 317936005998 Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351 317936005999 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 317936006000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936006001 ATP binding site [chemical binding]; other site 317936006002 putative Mg++ binding site [ion binding]; other site 317936006003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936006004 nucleotide binding region [chemical binding]; other site 317936006005 ATP-binding site [chemical binding]; other site 317936006006 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 317936006007 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 317936006008 pyrroline-5-carboxylate reductase; Region: PLN02688 317936006009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 317936006010 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 317936006011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 317936006012 catalytic residue [active] 317936006013 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 317936006014 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 317936006015 GTP-binding protein Der; Reviewed; Region: PRK00093 317936006016 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 317936006017 G1 box; other site 317936006018 GTP/Mg2+ binding site [chemical binding]; other site 317936006019 Switch I region; other site 317936006020 G2 box; other site 317936006021 Switch II region; other site 317936006022 G3 box; other site 317936006023 G4 box; other site 317936006024 G5 box; other site 317936006025 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 317936006026 G1 box; other site 317936006027 GTP/Mg2+ binding site [chemical binding]; other site 317936006028 Switch I region; other site 317936006029 G2 box; other site 317936006030 G3 box; other site 317936006031 Switch II region; other site 317936006032 G4 box; other site 317936006033 G5 box; other site 317936006034 phosphodiesterase YaeI; Provisional; Region: PRK11340 317936006035 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 317936006036 putative active site [active] 317936006037 putative metal binding site [ion binding]; other site 317936006038 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 317936006039 Isochorismatase family; Region: Isochorismatase; pfam00857 317936006040 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 317936006041 catalytic triad [active] 317936006042 conserved cis-peptide bond; other site 317936006043 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 317936006044 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 317936006045 active site 317936006046 putative substrate binding pocket [chemical binding]; other site 317936006047 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 317936006048 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 317936006049 Nucleoside recognition; Region: Gate; pfam07670 317936006050 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 317936006051 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936006052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936006053 non-specific DNA binding site [nucleotide binding]; other site 317936006054 salt bridge; other site 317936006055 sequence-specific DNA binding site [nucleotide binding]; other site 317936006056 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936006057 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006058 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006059 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936006060 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006061 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006062 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006063 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006064 TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665 317936006065 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 317936006066 DctM-like transporters; Region: DctM; pfam06808 317936006067 Response regulator receiver domain; Region: Response_reg; pfam00072 317936006068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006069 active site 317936006070 phosphorylation site [posttranslational modification] 317936006071 intermolecular recognition site; other site 317936006072 dimerization interface [polypeptide binding]; other site 317936006073 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 317936006074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936006075 putative active site [active] 317936006076 heme pocket [chemical binding]; other site 317936006077 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006078 dimer interface [polypeptide binding]; other site 317936006079 phosphorylation site [posttranslational modification] 317936006080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006081 ATP binding site [chemical binding]; other site 317936006082 Mg2+ binding site [ion binding]; other site 317936006083 G-X-G motif; other site 317936006084 Response regulator receiver domain; Region: Response_reg; pfam00072 317936006085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006086 active site 317936006087 phosphorylation site [posttranslational modification] 317936006088 intermolecular recognition site; other site 317936006089 dimerization interface [polypeptide binding]; other site 317936006090 Protein kinase domain; Region: Pkinase; pfam00069 317936006091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936006092 active site 317936006093 ATP binding site [chemical binding]; other site 317936006094 substrate binding site [chemical binding]; other site 317936006095 activation loop (A-loop); other site 317936006096 AAA ATPase domain; Region: AAA_16; pfam13191 317936006097 Predicted ATPase [General function prediction only]; Region: COG3899 317936006098 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936006099 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936006100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006101 dimer interface [polypeptide binding]; other site 317936006102 phosphorylation site [posttranslational modification] 317936006103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006104 ATP binding site [chemical binding]; other site 317936006105 Mg2+ binding site [ion binding]; other site 317936006106 G-X-G motif; other site 317936006107 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936006108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006109 active site 317936006110 phosphorylation site [posttranslational modification] 317936006111 intermolecular recognition site; other site 317936006112 dimerization interface [polypeptide binding]; other site 317936006113 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 317936006114 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 317936006115 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 317936006116 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 317936006117 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 317936006118 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 317936006119 Walker A/P-loop; other site 317936006120 ATP binding site [chemical binding]; other site 317936006121 Q-loop/lid; other site 317936006122 ABC transporter signature motif; other site 317936006123 Walker B; other site 317936006124 D-loop; other site 317936006125 H-loop/switch region; other site 317936006126 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 317936006127 GUN4-like; Region: GUN4; pfam05419 317936006128 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 317936006129 isocitrate dehydrogenase; Validated; Region: PRK07362 317936006130 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006131 putative active site [active] 317936006132 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 317936006133 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 317936006134 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 317936006135 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 317936006136 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936006137 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 317936006138 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 317936006139 putative active site [active] 317936006140 catalytic site [active] 317936006141 putative metal binding site [ion binding]; other site 317936006142 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 317936006143 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 317936006144 nucleotide binding pocket [chemical binding]; other site 317936006145 K-X-D-G motif; other site 317936006146 catalytic site [active] 317936006147 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 317936006148 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 317936006149 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 317936006150 Dimer interface [polypeptide binding]; other site 317936006151 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 317936006152 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 317936006153 active site 317936006154 catalytic site [active] 317936006155 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 317936006156 starch-binding site 2 [chemical binding]; other site 317936006157 starch-binding site 1 [chemical binding]; other site 317936006158 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 317936006159 Peptidase family M50; Region: Peptidase_M50; pfam02163 317936006160 active site 317936006161 putative substrate binding region [chemical binding]; other site 317936006162 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 317936006163 inhibitor binding site; inhibition site 317936006164 catalytic motif [active] 317936006165 Catalytic residue [active] 317936006166 Active site flap [active] 317936006167 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 317936006168 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 317936006169 FMN binding site [chemical binding]; other site 317936006170 active site 317936006171 catalytic residues [active] 317936006172 substrate binding site [chemical binding]; other site 317936006173 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 317936006174 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 317936006175 Tetramer interface [polypeptide binding]; other site 317936006176 active site 317936006177 FMN-binding site [chemical binding]; other site 317936006178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936006179 TPR motif; other site 317936006180 Uncharacterized conserved protein [Function unknown]; Region: COG4095 317936006181 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 317936006182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936006183 S-adenosylmethionine binding site [chemical binding]; other site 317936006184 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 317936006185 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 317936006186 ligand binding site [chemical binding]; other site 317936006187 NAD binding site [chemical binding]; other site 317936006188 dimerization interface [polypeptide binding]; other site 317936006189 catalytic site [active] 317936006190 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 317936006191 putative L-serine binding site [chemical binding]; other site 317936006192 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006193 putative active site [active] 317936006194 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936006195 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 317936006196 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936006197 catalytic residue [active] 317936006198 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 317936006199 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006200 putative active site [active] 317936006201 glycogen branching enzyme; Provisional; Region: PRK05402 317936006202 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 317936006203 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 317936006204 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 317936006205 active site 317936006206 catalytic site [active] 317936006207 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 317936006208 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 317936006209 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 317936006210 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 317936006211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936006212 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 317936006213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 317936006214 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936006215 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936006216 ligand binding site [chemical binding]; other site 317936006217 flexible hinge region; other site 317936006218 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 317936006219 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 317936006220 putative active site [active] 317936006221 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936006222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936006223 Walker A/P-loop; other site 317936006224 ATP binding site [chemical binding]; other site 317936006225 Q-loop/lid; other site 317936006226 ABC transporter signature motif; other site 317936006227 Walker B; other site 317936006228 D-loop; other site 317936006229 H-loop/switch region; other site 317936006230 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 317936006231 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 317936006232 Homeodomain-like domain; Region: HTH_23; pfam13384 317936006233 Winged helix-turn helix; Region: HTH_29; pfam13551 317936006234 Winged helix-turn helix; Region: HTH_33; pfam13592 317936006235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936006236 ligand binding site [chemical binding]; other site 317936006237 flexible hinge region; other site 317936006238 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 317936006239 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 317936006240 putative active site [active] 317936006241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936006242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936006243 Walker A/P-loop; other site 317936006244 ATP binding site [chemical binding]; other site 317936006245 Q-loop/lid; other site 317936006246 ABC transporter signature motif; other site 317936006247 Walker B; other site 317936006248 D-loop; other site 317936006249 H-loop/switch region; other site 317936006250 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 317936006251 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 317936006252 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936006253 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 317936006254 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 317936006255 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 317936006256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936006257 motif II; other site 317936006258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 317936006259 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 317936006260 putative efflux protein, MATE family; Region: matE; TIGR00797 317936006261 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 317936006262 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 317936006263 active site 317936006264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 317936006265 EamA-like transporter family; Region: EamA; pfam00892 317936006266 TPR repeat; Region: TPR_11; pfam13414 317936006267 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936006268 binding surface 317936006269 TPR motif; other site 317936006270 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006271 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936006273 binding surface 317936006274 TPR motif; other site 317936006275 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006276 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006277 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006278 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936006279 TPR motif; other site 317936006280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006281 binding surface 317936006282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936006284 binding surface 317936006285 TPR motif; other site 317936006286 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006288 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936006289 CHAT domain; Region: CHAT; cl17868 317936006290 methionine sulfoxide reductase B; Provisional; Region: PRK00222 317936006291 SelR domain; Region: SelR; pfam01641 317936006292 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 317936006293 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 317936006294 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 317936006295 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 317936006296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936006297 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 317936006298 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936006299 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 317936006300 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936006301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936006302 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 317936006303 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 317936006304 N- and C-terminal domain interface [polypeptide binding]; other site 317936006305 active site 317936006306 MgATP binding site [chemical binding]; other site 317936006307 catalytic site [active] 317936006308 metal binding site [ion binding]; metal-binding site 317936006309 glycerol binding site [chemical binding]; other site 317936006310 homotetramer interface [polypeptide binding]; other site 317936006311 homodimer interface [polypeptide binding]; other site 317936006312 FBP binding site [chemical binding]; other site 317936006313 protein IIAGlc interface [polypeptide binding]; other site 317936006314 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 317936006315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936006316 PAS domain; Region: PAS_9; pfam13426 317936006317 putative active site [active] 317936006318 heme pocket [chemical binding]; other site 317936006319 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936006320 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936006321 putative switch regulator; other site 317936006322 non-specific DNA interactions [nucleotide binding]; other site 317936006323 DNA binding site [nucleotide binding] 317936006324 sequence specific DNA binding site [nucleotide binding]; other site 317936006325 putative cAMP binding site [chemical binding]; other site 317936006326 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936006327 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 317936006328 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936006329 active site 317936006330 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 317936006331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936006332 FeS/SAM binding site; other site 317936006333 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 317936006334 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 317936006335 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936006336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936006337 S-adenosylmethionine binding site [chemical binding]; other site 317936006338 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936006339 catalytic core [active] 317936006340 Protein kinase domain; Region: Pkinase; pfam00069 317936006341 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936006342 active site 317936006343 ATP binding site [chemical binding]; other site 317936006344 substrate binding site [chemical binding]; other site 317936006345 activation loop (A-loop); other site 317936006346 AAA ATPase domain; Region: AAA_16; pfam13191 317936006347 Predicted ATPase [General function prediction only]; Region: COG3899 317936006348 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936006349 GAF domain; Region: GAF; pfam01590 317936006350 PAS domain S-box; Region: sensory_box; TIGR00229 317936006351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936006352 putative active site [active] 317936006353 heme pocket [chemical binding]; other site 317936006354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936006355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006356 ATP binding site [chemical binding]; other site 317936006357 Mg2+ binding site [ion binding]; other site 317936006358 G-X-G motif; other site 317936006359 Protein kinase domain; Region: Pkinase; pfam00069 317936006360 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936006361 active site 317936006362 ATP binding site [chemical binding]; other site 317936006363 substrate binding site [chemical binding]; other site 317936006364 activation loop (A-loop); other site 317936006365 AAA ATPase domain; Region: AAA_16; pfam13191 317936006366 Predicted ATPase [General function prediction only]; Region: COG3899 317936006367 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936006368 GAF domain; Region: GAF; pfam01590 317936006369 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936006370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006371 ATP binding site [chemical binding]; other site 317936006372 Mg2+ binding site [ion binding]; other site 317936006373 G-X-G motif; other site 317936006374 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006375 putative active site [active] 317936006376 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 317936006377 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 317936006378 active site 317936006379 putative substrate binding pocket [chemical binding]; other site 317936006380 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 317936006381 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 317936006382 putative substrate binding pocket [chemical binding]; other site 317936006383 AC domain interface; other site 317936006384 catalytic triad [active] 317936006385 AB domain interface; other site 317936006386 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 317936006387 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 317936006388 putative active site [active] 317936006389 oxyanion strand; other site 317936006390 catalytic triad [active] 317936006391 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 317936006392 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936006393 S-adenosylmethionine binding site [chemical binding]; other site 317936006394 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 317936006395 Cytochrome c; Region: Cytochrom_C; pfam00034 317936006396 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 317936006397 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 317936006398 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936006399 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936006400 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936006401 Walker A/P-loop; other site 317936006402 ATP binding site [chemical binding]; other site 317936006403 Q-loop/lid; other site 317936006404 ABC transporter signature motif; other site 317936006405 Walker B; other site 317936006406 D-loop; other site 317936006407 H-loop/switch region; other site 317936006408 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 317936006409 active site 317936006410 substrate binding site [chemical binding]; other site 317936006411 trimer interface [polypeptide binding]; other site 317936006412 CoA binding site [chemical binding]; other site 317936006413 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 317936006414 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936006415 catalytic residue [active] 317936006416 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 317936006417 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 317936006418 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 317936006419 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 317936006420 generic binding surface II; other site 317936006421 ssDNA binding site; other site 317936006422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936006423 ATP binding site [chemical binding]; other site 317936006424 putative Mg++ binding site [ion binding]; other site 317936006425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936006426 nucleotide binding region [chemical binding]; other site 317936006427 ATP-binding site [chemical binding]; other site 317936006428 elongation factor Ts; Provisional; Region: tsf; PRK09377 317936006429 UBA/TS-N domain; Region: UBA; pfam00627 317936006430 Elongation factor TS; Region: EF_TS; pfam00889 317936006431 Elongation factor TS; Region: EF_TS; pfam00889 317936006432 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 317936006433 rRNA interaction site [nucleotide binding]; other site 317936006434 S8 interaction site; other site 317936006435 putative laminin-1 binding site; other site 317936006436 Caspase domain; Region: Peptidase_C14; pfam00656 317936006437 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 317936006438 Sel1-like repeats; Region: SEL1; smart00671 317936006439 Sel1-like repeats; Region: SEL1; smart00671 317936006440 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 317936006441 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 317936006442 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936006443 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006444 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006445 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006446 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006448 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006449 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936006450 arogenate dehydrogenase; Reviewed; Region: PRK07417 317936006451 prephenate dehydrogenase; Validated; Region: PRK08507 317936006452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 317936006453 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936006454 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 317936006455 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 317936006456 conjugal transfer protein TraL; Provisional; Region: PRK13886 317936006457 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 317936006458 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 317936006459 NAD(P) binding site [chemical binding]; other site 317936006460 catalytic residues [active] 317936006461 acetolactate synthase; Reviewed; Region: PRK08322 317936006462 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 317936006463 PYR/PP interface [polypeptide binding]; other site 317936006464 dimer interface [polypeptide binding]; other site 317936006465 TPP binding site [chemical binding]; other site 317936006466 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 317936006467 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 317936006468 TPP-binding site [chemical binding]; other site 317936006469 dimer interface [polypeptide binding]; other site 317936006470 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 317936006471 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 317936006472 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 317936006473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936006474 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 317936006475 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 317936006476 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428 317936006477 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 317936006478 dimerization interface [polypeptide binding]; other site 317936006479 active site 317936006480 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936006481 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936006482 phosphopeptide binding site; other site 317936006483 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 317936006484 CHAT domain; Region: CHAT; cl17868 317936006485 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936006486 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936006487 phosphopeptide binding site; other site 317936006488 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 317936006489 Protein phosphatase 2C; Region: PP2C; pfam00481 317936006490 active site 317936006491 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 317936006492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936006493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006494 active site 317936006495 phosphorylation site [posttranslational modification] 317936006496 intermolecular recognition site; other site 317936006497 dimerization interface [polypeptide binding]; other site 317936006498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936006499 DNA binding residues [nucleotide binding] 317936006500 dimerization interface [polypeptide binding]; other site 317936006501 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 317936006502 Predicted membrane protein [Function unknown]; Region: COG3431 317936006503 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 317936006504 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 317936006505 [4Fe-4S] binding site [ion binding]; other site 317936006506 molybdopterin cofactor binding site; other site 317936006507 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 317936006508 molybdopterin cofactor binding site; other site 317936006509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936006510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936006511 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 317936006512 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 317936006513 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 317936006514 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 317936006515 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 317936006516 iron-sulfur cluster [ion binding]; other site 317936006517 [2Fe-2S] cluster binding site [ion binding]; other site 317936006518 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 317936006519 HEAT repeats; Region: HEAT_2; pfam13646 317936006520 HEAT repeats; Region: HEAT_2; pfam13646 317936006521 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006522 putative active site [active] 317936006523 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 317936006524 prolyl-tRNA synthetase; Provisional; Region: PRK09194 317936006525 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 317936006526 dimer interface [polypeptide binding]; other site 317936006527 motif 1; other site 317936006528 active site 317936006529 motif 2; other site 317936006530 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 317936006531 putative deacylase active site [active] 317936006532 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 317936006533 active site 317936006534 motif 3; other site 317936006535 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 317936006536 anticodon binding site; other site 317936006537 Sporulation and spore germination; Region: Germane; pfam10646 317936006538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936006539 putative DNA binding site [nucleotide binding]; other site 317936006540 putative Zn2+ binding site [ion binding]; other site 317936006541 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 317936006542 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 317936006543 carboxyltransferase (CT) interaction site; other site 317936006544 biotinylation site [posttranslational modification]; other site 317936006545 elongation factor P; Validated; Region: PRK00529 317936006546 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 317936006547 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 317936006548 RNA binding site [nucleotide binding]; other site 317936006549 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 317936006550 RNA binding site [nucleotide binding]; other site 317936006551 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 317936006552 active site 317936006553 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006554 putative active site [active] 317936006555 thiamine monophosphate kinase; Provisional; Region: PRK05731 317936006556 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 317936006557 ATP binding site [chemical binding]; other site 317936006558 dimerization interface [polypeptide binding]; other site 317936006559 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 317936006560 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 317936006561 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 317936006562 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 317936006563 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 317936006564 active site 317936006565 (T/H)XGH motif; other site 317936006566 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 317936006567 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 317936006568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936006569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936006570 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 317936006571 FAD binding domain; Region: FAD_binding_4; pfam01565 317936006572 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 317936006573 hypothetical protein; Validated; Region: PRK00153 317936006574 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 317936006575 Low molecular weight phosphatase family; Region: LMWPc; cd00115 317936006576 active site 317936006577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936006578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006579 active site 317936006580 phosphorylation site [posttranslational modification] 317936006581 intermolecular recognition site; other site 317936006582 dimerization interface [polypeptide binding]; other site 317936006583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936006584 DNA binding residues [nucleotide binding] 317936006585 dimerization interface [polypeptide binding]; other site 317936006586 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 317936006587 SmpB-tmRNA interface; other site 317936006588 putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947 317936006589 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 317936006590 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936006591 GAF domain; Region: GAF; pfam01590 317936006592 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936006593 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006594 dimer interface [polypeptide binding]; other site 317936006595 phosphorylation site [posttranslational modification] 317936006596 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 317936006597 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 317936006598 inhibitor-cofactor binding pocket; inhibition site 317936006599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936006600 catalytic residue [active] 317936006601 cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156 317936006602 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 317936006603 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 317936006604 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 317936006605 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 317936006606 SLBB domain; Region: SLBB; pfam10531 317936006607 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936006608 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 317936006609 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 317936006610 Nucleotide binding site [chemical binding]; other site 317936006611 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 317936006612 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 317936006613 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 317936006614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 317936006615 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 317936006616 Family of unknown function (DUF490); Region: DUF490; pfam04357 317936006617 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 317936006618 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 317936006619 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936006620 active site 317936006621 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 317936006622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936006623 dimer interface [polypeptide binding]; other site 317936006624 conserved gate region; other site 317936006625 putative PBP binding loops; other site 317936006626 ABC-ATPase subunit interface; other site 317936006627 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 317936006628 lipoprotein signal peptidase; Provisional; Region: PRK14787 317936006629 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 317936006630 Predicted membrane protein [Function unknown]; Region: COG2324 317936006631 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 317936006632 ribosomal protein L21; Region: rpl21; CHL00075 317936006633 hypothetical protein; Validated; Region: PRK00110 317936006634 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 317936006635 heme binding pocket [chemical binding]; other site 317936006636 Animal prostaglandin endoperoxide synthase and related bacterial proteins; Region: prostaglandin_endoperoxide_synthase; cd09816 317936006637 substrate binding site [chemical binding]; other site 317936006638 homodimer interface [polypeptide binding]; other site 317936006639 heme binding site [chemical binding]; other site 317936006640 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 317936006641 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364 317936006642 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 317936006643 Tetratricopeptide repeat; Region: TPR_6; pfam13174 317936006644 TPR repeat; Region: TPR_11; pfam13414 317936006645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936006646 binding surface 317936006647 TPR motif; other site 317936006648 TPR repeat; Region: TPR_11; pfam13414 317936006649 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006650 putative active site [active] 317936006651 Protein of unknown function DUF262; Region: DUF262; pfam03235 317936006652 Uncharacterized conserved protein [Function unknown]; Region: COG1479 317936006653 Protein of unknown function DUF262; Region: DUF262; pfam03235 317936006654 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 317936006655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936006656 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 317936006657 putative substrate translocation pore; other site 317936006658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936006659 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 317936006660 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936006661 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936006662 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 317936006663 MarR family; Region: MarR; pfam01047 317936006664 acetyl-CoA synthetase; Provisional; Region: PRK00174 317936006665 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 317936006666 active site 317936006667 CoA binding site [chemical binding]; other site 317936006668 acyl-activating enzyme (AAE) consensus motif; other site 317936006669 AMP binding site [chemical binding]; other site 317936006670 acetate binding site [chemical binding]; other site 317936006671 Integral membrane protein TerC family; Region: TerC; cl10468 317936006672 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 317936006673 active site 317936006674 multimer interface [polypeptide binding]; other site 317936006675 arginine decarboxylase; Provisional; Region: PRK05354 317936006676 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 317936006677 dimer interface [polypeptide binding]; other site 317936006678 active site 317936006679 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 317936006680 catalytic residues [active] 317936006681 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 317936006682 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 317936006683 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 317936006684 active site 317936006685 Substrate binding site; other site 317936006686 Mg++ binding site; other site 317936006687 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 317936006688 putative trimer interface [polypeptide binding]; other site 317936006689 putative CoA binding site [chemical binding]; other site 317936006690 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 317936006691 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936006692 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936006693 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 317936006694 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 317936006695 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 317936006696 DNA photolyase; Region: DNA_photolyase; pfam00875 317936006697 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 317936006698 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 317936006699 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 317936006700 catalytic triad [active] 317936006701 Phosphotransferase enzyme family; Region: APH; pfam01636 317936006702 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 317936006703 substrate binding site [chemical binding]; other site 317936006704 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936006705 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936006706 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936006707 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936006708 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936006709 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936006710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936006711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936006712 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 317936006713 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 317936006714 Cache domain; Region: Cache_1; pfam02743 317936006715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006716 dimer interface [polypeptide binding]; other site 317936006717 phosphorylation site [posttranslational modification] 317936006718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006719 ATP binding site [chemical binding]; other site 317936006720 Mg2+ binding site [ion binding]; other site 317936006721 G-X-G motif; other site 317936006722 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936006723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006724 active site 317936006725 phosphorylation site [posttranslational modification] 317936006726 intermolecular recognition site; other site 317936006727 dimerization interface [polypeptide binding]; other site 317936006728 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936006729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006730 active site 317936006731 phosphorylation site [posttranslational modification] 317936006732 intermolecular recognition site; other site 317936006733 dimerization interface [polypeptide binding]; other site 317936006734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936006735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006736 dimer interface [polypeptide binding]; other site 317936006737 phosphorylation site [posttranslational modification] 317936006738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006739 ATP binding site [chemical binding]; other site 317936006740 Mg2+ binding site [ion binding]; other site 317936006741 G-X-G motif; other site 317936006742 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936006743 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 317936006744 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 317936006745 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936006746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936006747 NAD(P) binding site [chemical binding]; other site 317936006748 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 317936006749 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 317936006750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936006751 active site 317936006752 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 317936006753 Uncharacterized conserved protein [Function unknown]; Region: COG3791 317936006754 DNA polymerase III subunit delta; Validated; Region: PRK07452 317936006755 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 317936006756 Domain of unknown function (DUF4168); Region: DUF4168; pfam13767 317936006757 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 317936006758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006759 ATP binding site [chemical binding]; other site 317936006760 Mg2+ binding site [ion binding]; other site 317936006761 G-X-G motif; other site 317936006762 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 317936006763 ATP binding site [chemical binding]; other site 317936006764 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 317936006765 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 317936006766 active site residue [active] 317936006767 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 317936006768 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 317936006769 active site 317936006770 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 317936006771 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936006772 active site 317936006773 ATP binding site [chemical binding]; other site 317936006774 substrate binding site [chemical binding]; other site 317936006775 activation loop (A-loop); other site 317936006776 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 317936006777 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 317936006778 G1 box; other site 317936006779 GTP/Mg2+ binding site [chemical binding]; other site 317936006780 Switch I region; other site 317936006781 G2 box; other site 317936006782 Switch II region; other site 317936006783 G3 box; other site 317936006784 G4 box; other site 317936006785 G5 box; other site 317936006786 Domain of unknown function (DUF697); Region: DUF697; pfam05128 317936006787 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 317936006788 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 317936006789 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 317936006790 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 317936006791 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 317936006792 dimer interface [polypeptide binding]; other site 317936006793 decamer (pentamer of dimers) interface [polypeptide binding]; other site 317936006794 catalytic triad [active] 317936006795 peroxidatic and resolving cysteines [active] 317936006796 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 317936006797 putative catalytic residues [active] 317936006798 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 317936006799 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 317936006800 FOG: CBS domain [General function prediction only]; Region: COG0517 317936006801 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 317936006802 CP12 domain; Region: CP12; pfam02672 317936006803 Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941 317936006804 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 317936006805 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 317936006806 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 317936006807 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936006808 catalytic loop [active] 317936006809 iron binding site [ion binding]; other site 317936006810 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 317936006811 4Fe-4S binding domain; Region: Fer4; pfam00037 317936006812 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 317936006813 dimer interface [polypeptide binding]; other site 317936006814 [2Fe-2S] cluster binding site [ion binding]; other site 317936006815 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 317936006816 SLBB domain; Region: SLBB; pfam10531 317936006817 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 317936006818 bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571 317936006819 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 317936006820 putative dimer interface [polypeptide binding]; other site 317936006821 [2Fe-2S] cluster binding site [ion binding]; other site 317936006822 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936006823 Ligand Binding Site [chemical binding]; other site 317936006824 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 317936006825 active site 317936006826 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 317936006827 Uncharacterized conserved protein [Function unknown]; Region: COG1434 317936006828 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 317936006829 putative active site [active] 317936006830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 317936006831 Ecdysteroid kinase; Region: EcKinase; cl17738 317936006832 Predicted kinase [General function prediction only]; Region: COG0645 317936006833 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 317936006834 ATP-binding site [chemical binding]; other site 317936006835 Gluconate-6-phosphate binding site [chemical binding]; other site 317936006836 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 317936006837 5S rRNA interface [nucleotide binding]; other site 317936006838 CTC domain interface [polypeptide binding]; other site 317936006839 L16 interface [polypeptide binding]; other site 317936006840 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 317936006841 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 317936006842 GDP-binding site [chemical binding]; other site 317936006843 ACT binding site; other site 317936006844 IMP binding site; other site 317936006845 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 317936006846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936006847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936006848 dimer interface [polypeptide binding]; other site 317936006849 phosphorylation site [posttranslational modification] 317936006850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936006851 ATP binding site [chemical binding]; other site 317936006852 Mg2+ binding site [ion binding]; other site 317936006853 G-X-G motif; other site 317936006854 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936006855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936006856 active site 317936006857 phosphorylation site [posttranslational modification] 317936006858 intermolecular recognition site; other site 317936006859 dimerization interface [polypeptide binding]; other site 317936006860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936006861 DNA binding site [nucleotide binding] 317936006862 Predicted membrane protein [Function unknown]; Region: COG1808 317936006863 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936006864 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 317936006865 Walker A/P-loop; other site 317936006866 ATP binding site [chemical binding]; other site 317936006867 Q-loop/lid; other site 317936006868 ABC transporter signature motif; other site 317936006869 Walker B; other site 317936006870 D-loop; other site 317936006871 H-loop/switch region; other site 317936006872 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 317936006873 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 317936006874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936006875 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 317936006876 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 317936006877 iron-sulfur cluster [ion binding]; other site 317936006878 [2Fe-2S] cluster binding site [ion binding]; other site 317936006879 Uncharacterized conserved protein [Function unknown]; Region: COG3349 317936006880 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936006881 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 317936006882 Probable Catalytic site; other site 317936006883 metal-binding site 317936006884 Class I aldolases; Region: Aldolase_Class_I; cl17187 317936006885 catalytic residue [active] 317936006886 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 317936006887 RNA/DNA hybrid binding site [nucleotide binding]; other site 317936006888 active site 317936006889 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 317936006890 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 317936006891 active site 317936006892 PBP superfamily domain; Region: PBP_like_2; cl17296 317936006893 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 317936006894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936006895 dimer interface [polypeptide binding]; other site 317936006896 conserved gate region; other site 317936006897 putative PBP binding loops; other site 317936006898 ABC-ATPase subunit interface; other site 317936006899 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 317936006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936006901 dimer interface [polypeptide binding]; other site 317936006902 conserved gate region; other site 317936006903 putative PBP binding loops; other site 317936006904 ABC-ATPase subunit interface; other site 317936006905 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 317936006906 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 317936006907 Walker A/P-loop; other site 317936006908 ATP binding site [chemical binding]; other site 317936006909 Q-loop/lid; other site 317936006910 ABC transporter signature motif; other site 317936006911 Walker B; other site 317936006912 D-loop; other site 317936006913 H-loop/switch region; other site 317936006914 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 317936006915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936006916 ATP binding site [chemical binding]; other site 317936006917 putative Mg++ binding site [ion binding]; other site 317936006918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936006919 nucleotide binding region [chemical binding]; other site 317936006920 ATP-binding site [chemical binding]; other site 317936006921 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 317936006922 Protein of unknown function (DUF790); Region: DUF790; pfam05626 317936006923 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 317936006924 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936006925 P-loop; other site 317936006926 Magnesium ion binding site [ion binding]; other site 317936006927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936006928 Magnesium ion binding site [ion binding]; other site 317936006929 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 317936006930 catalytic site [active] 317936006931 putative active site [active] 317936006932 putative substrate binding site [chemical binding]; other site 317936006933 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 317936006934 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 317936006935 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 317936006936 AAA ATPase domain; Region: AAA_16; pfam13191 317936006937 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 317936006938 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006939 putative active site [active] 317936006940 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 317936006941 iron-sulfur cluster [ion binding]; other site 317936006942 [2Fe-2S] cluster binding site [ion binding]; other site 317936006943 CAAX protease self-immunity; Region: Abi; pfam02517 317936006944 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 317936006945 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 317936006946 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936006947 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936006948 catalytic loop [active] 317936006949 iron binding site [ion binding]; other site 317936006950 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006951 putative active site [active] 317936006952 Hemerythrin-like domain; Region: Hr-like; cd12108 317936006953 Fe binding site [ion binding]; other site 317936006954 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 317936006955 Predicted membrane protein [Function unknown]; Region: COG4244 317936006956 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 317936006957 Prominin; Region: Prominin; pfam05478 317936006958 hypothetical protein; Provisional; Region: PRK04194 317936006959 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 317936006960 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 317936006961 Protein of unknown function (DUF751); Region: DUF751; pfam05421 317936006962 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 317936006963 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936006964 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936006965 active site 317936006966 ATP binding site [chemical binding]; other site 317936006967 substrate binding site [chemical binding]; other site 317936006968 activation loop (A-loop); other site 317936006969 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 317936006970 Peptidase family M50; Region: Peptidase_M50; pfam02163 317936006971 active site 317936006972 putative substrate binding region [chemical binding]; other site 317936006973 FOG: CBS domain [General function prediction only]; Region: COG0517 317936006974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 317936006975 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936006976 putative active site [active] 317936006977 RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717 317936006978 mbt repeat; Region: MBT; cl17705 317936006979 Cupin superfamily protein; Region: Cupin_4; pfam08007 317936006980 Cupin-like domain; Region: Cupin_8; pfam13621 317936006981 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 317936006982 metal ion-dependent adhesion site (MIDAS); other site 317936006983 VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457 317936006984 metal ion-dependent adhesion site (MIDAS); other site 317936006985 Predicted transcriptional regulators [Transcription]; Region: COG1733 317936006986 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 317936006987 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936006988 RNA recognition motif; Region: RRM; smart00360 317936006989 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936006990 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 317936006991 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 317936006992 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 317936006993 G1 box; other site 317936006994 putative GEF interaction site [polypeptide binding]; other site 317936006995 GTP/Mg2+ binding site [chemical binding]; other site 317936006996 Switch I region; other site 317936006997 G2 box; other site 317936006998 G3 box; other site 317936006999 Switch II region; other site 317936007000 G4 box; other site 317936007001 G5 box; other site 317936007002 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 317936007003 Tic20-like protein; Region: Tic20; pfam09685 317936007004 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 317936007005 Vacuolar 14 Fab1-binding region; Region: Vac14_Fab1_bd; pfam12755 317936007006 Vacuolar 14 Fab1-binding region; Region: Vac14_Fab1_bd; pfam12755 317936007007 HEAT-like repeat; Region: HEAT_EZ; pfam13513 317936007008 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 317936007009 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 317936007010 dimer interface [polypeptide binding]; other site 317936007011 active site 317936007012 Schiff base residues; other site 317936007013 YcfA-like protein; Region: YcfA; cl00752 317936007014 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 317936007015 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 317936007016 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936007017 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936007018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007019 binding surface 317936007020 TPR motif; other site 317936007021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007022 binding surface 317936007023 TPR motif; other site 317936007024 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936007025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007026 binding surface 317936007027 TPR motif; other site 317936007028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007029 binding surface 317936007030 TPR motif; other site 317936007031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007032 binding surface 317936007033 TPR motif; other site 317936007034 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 317936007035 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 317936007036 23S rRNA binding site [nucleotide binding]; other site 317936007037 L21 binding site [polypeptide binding]; other site 317936007038 L13 binding site [polypeptide binding]; other site 317936007039 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 317936007040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936007041 substrate binding pocket [chemical binding]; other site 317936007042 membrane-bound complex binding site; other site 317936007043 hinge residues; other site 317936007044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007045 binding surface 317936007046 TPR repeat; Region: TPR_11; pfam13414 317936007047 TPR motif; other site 317936007048 TPR repeat; Region: TPR_11; pfam13414 317936007049 tyramine oxidase; Provisional; Region: tynA; PRK11504 317936007050 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 317936007051 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 317936007052 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 317936007053 Uncharacterized conserved protein [Function unknown]; Region: COG2442 317936007054 photochlorophyllide reductase subunit B; Region: chlB; CHL00076 317936007055 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 317936007056 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 317936007057 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 317936007058 dimerization interface [polypeptide binding]; other site 317936007059 active site 317936007060 metal binding site [ion binding]; metal-binding site 317936007061 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 317936007062 dsRNA binding site [nucleotide binding]; other site 317936007063 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 317936007064 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 317936007065 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 317936007066 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 317936007067 active site 317936007068 metal binding site [ion binding]; metal-binding site 317936007069 interdomain interaction site; other site 317936007070 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 317936007071 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952 317936007072 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 317936007073 dimer interface [polypeptide binding]; other site 317936007074 active site 317936007075 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 317936007076 active site 317936007077 photosystem I assembly protein Ycf4; Provisional; Region: PRK02542 317936007078 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 317936007079 D1 interface; other site 317936007080 chlorophyll binding site; other site 317936007081 pheophytin binding site; other site 317936007082 beta carotene binding site; other site 317936007083 cytochrome b559 beta interface; other site 317936007084 quinone binding site; other site 317936007085 cytochrome b559 alpha interface; other site 317936007086 protein J interface; other site 317936007087 protein H interface; other site 317936007088 protein X interface; other site 317936007089 core light harvesting protein interface; other site 317936007090 protein L interface; other site 317936007091 CP43 interface; other site 317936007092 protein T interface; other site 317936007093 Fe binding site [ion binding]; other site 317936007094 protein M interface; other site 317936007095 Mn-stabilizing polypeptide interface; other site 317936007096 bromide binding site; other site 317936007097 cytochrome c-550 interface; other site 317936007098 photosystem II 44 kDa protein; Region: psbC; CHL00035 317936007099 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 317936007100 Uncharacterized conserved protein [Function unknown]; Region: COG4279 317936007101 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 317936007102 SNF2 Helicase protein; Region: DUF3670; pfam12419 317936007103 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936007104 ATP binding site [chemical binding]; other site 317936007105 putative Mg++ binding site [ion binding]; other site 317936007106 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936007107 nucleotide binding region [chemical binding]; other site 317936007108 ATP-binding site [chemical binding]; other site 317936007109 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 317936007110 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 317936007111 RNase E interface [polypeptide binding]; other site 317936007112 trimer interface [polypeptide binding]; other site 317936007113 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 317936007114 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 317936007115 RNase E interface [polypeptide binding]; other site 317936007116 trimer interface [polypeptide binding]; other site 317936007117 active site 317936007118 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 317936007119 putative nucleic acid binding region [nucleotide binding]; other site 317936007120 G-X-X-G motif; other site 317936007121 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 317936007122 RNA binding site [nucleotide binding]; other site 317936007123 domain interface; other site 317936007124 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 317936007125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936007126 dimer interface [polypeptide binding]; other site 317936007127 phosphorylation site [posttranslational modification] 317936007128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936007129 ATP binding site [chemical binding]; other site 317936007130 Mg2+ binding site [ion binding]; other site 317936007131 G-X-G motif; other site 317936007132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936007133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007134 active site 317936007135 phosphorylation site [posttranslational modification] 317936007136 intermolecular recognition site; other site 317936007137 dimerization interface [polypeptide binding]; other site 317936007138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936007139 DNA binding site [nucleotide binding] 317936007140 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 317936007141 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 317936007142 dimer interface [polypeptide binding]; other site 317936007143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936007144 catalytic residue [active] 317936007145 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 317936007146 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 317936007147 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 317936007148 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 317936007149 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936007150 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 317936007151 ligand binding site [chemical binding]; other site 317936007152 flexible hinge region; other site 317936007153 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936007154 putative switch regulator; other site 317936007155 non-specific DNA interactions [nucleotide binding]; other site 317936007156 DNA binding site [nucleotide binding] 317936007157 sequence specific DNA binding site [nucleotide binding]; other site 317936007158 putative cAMP binding site [chemical binding]; other site 317936007159 enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370 317936007160 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 317936007161 NAD binding site [chemical binding]; other site 317936007162 homotetramer interface [polypeptide binding]; other site 317936007163 homodimer interface [polypeptide binding]; other site 317936007164 substrate binding site [chemical binding]; other site 317936007165 active site 317936007166 imidazoleglycerol-phosphate dehydratase; Region: PLN02800 317936007167 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 317936007168 putative active site pocket [active] 317936007169 4-fold oligomerization interface [polypeptide binding]; other site 317936007170 metal binding residues [ion binding]; metal-binding site 317936007171 3-fold/trimer interface [polypeptide binding]; other site 317936007172 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936007173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936007174 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 317936007175 Walker A/P-loop; other site 317936007176 ATP binding site [chemical binding]; other site 317936007177 Q-loop/lid; other site 317936007178 ABC transporter signature motif; other site 317936007179 Walker B; other site 317936007180 D-loop; other site 317936007181 H-loop/switch region; other site 317936007182 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 317936007183 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 317936007184 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 317936007185 SLBB domain; Region: SLBB; pfam10531 317936007186 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 317936007187 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 317936007188 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936007189 HflK protein; Region: hflK; TIGR01933 317936007190 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 317936007191 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 317936007192 dihydropteroate synthase; Region: DHPS; TIGR01496 317936007193 substrate binding pocket [chemical binding]; other site 317936007194 dimer interface [polypeptide binding]; other site 317936007195 inhibitor binding site; inhibition site 317936007196 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 317936007197 triosephosphate isomerase; Provisional; Region: PRK14565 317936007198 substrate binding site [chemical binding]; other site 317936007199 dimer interface [polypeptide binding]; other site 317936007200 catalytic triad [active] 317936007201 Dynamin family; Region: Dynamin_N; pfam00350 317936007202 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 317936007203 G1 box; other site 317936007204 GTP/Mg2+ binding site [chemical binding]; other site 317936007205 Switch I region; other site 317936007206 G2 box; other site 317936007207 Switch II region; other site 317936007208 G3 box; other site 317936007209 G4 box; other site 317936007210 G5 box; other site 317936007211 Domain of unknown function (DUF697); Region: DUF697; pfam05128 317936007212 Right handed beta helix region; Region: Beta_helix; pfam13229 317936007213 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 317936007214 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 317936007215 thiamine phosphate binding site [chemical binding]; other site 317936007216 active site 317936007217 pyrophosphate binding site [ion binding]; other site 317936007218 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 317936007219 thiS-thiF/thiG interaction site; other site 317936007220 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 317936007221 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936007222 Protein of unknown function (DUF1517); Region: DUF1517; pfam07466 317936007223 Conserved TM helix; Region: TM_helix; pfam05552 317936007224 Conserved TM helix; Region: TM_helix; pfam05552 317936007225 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 317936007226 hydrophobic ligand binding site; other site 317936007227 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 317936007228 isoleucyl-tRNA synthetase; Region: PLN02843 317936007229 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 317936007230 HIGH motif; other site 317936007231 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 317936007232 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 317936007233 active site 317936007234 KMSKS motif; other site 317936007235 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 317936007236 tRNA binding surface [nucleotide binding]; other site 317936007237 anticodon binding site; other site 317936007238 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 317936007239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936007240 non-specific DNA binding site [nucleotide binding]; other site 317936007241 salt bridge; other site 317936007242 sequence-specific DNA binding site [nucleotide binding]; other site 317936007243 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 317936007244 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 317936007245 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 317936007246 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 317936007247 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 317936007248 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 317936007249 substrate binding site [chemical binding]; other site 317936007250 glutamase interaction surface [polypeptide binding]; other site 317936007251 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 317936007252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936007253 Walker A motif; other site 317936007254 ATP binding site [chemical binding]; other site 317936007255 Walker B motif; other site 317936007256 arginine finger; other site 317936007257 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 317936007258 TPR repeat; Region: TPR_11; pfam13414 317936007259 TPR repeat; Region: TPR_11; pfam13414 317936007260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007261 binding surface 317936007262 TPR motif; other site 317936007263 TPR repeat; Region: TPR_11; pfam13414 317936007264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007265 binding surface 317936007266 TPR motif; other site 317936007267 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 317936007268 haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1 317936007269 hypothetical protein; Provisional; Region: PRK02724 317936007270 Thf1-like protein; Reviewed; Region: PRK13266 317936007271 photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060 317936007272 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 317936007273 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936007274 anti sigma factor interaction site; other site 317936007275 regulatory phosphorylation site [posttranslational modification]; other site 317936007276 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 317936007277 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 317936007278 Domain of unknown function DUF59; Region: DUF59; pfam01883 317936007279 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 317936007280 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 317936007281 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 317936007282 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 317936007283 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 317936007284 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936007285 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 317936007286 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 317936007287 Ligand Binding Site [chemical binding]; other site 317936007288 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936007289 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 317936007290 NAD binding site [chemical binding]; other site 317936007291 putative substrate binding site 2 [chemical binding]; other site 317936007292 putative substrate binding site 1 [chemical binding]; other site 317936007293 active site 317936007294 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 317936007295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936007296 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 317936007297 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 317936007298 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 317936007299 active site 317936007300 NTP binding site [chemical binding]; other site 317936007301 metal binding triad [ion binding]; metal-binding site 317936007302 antibiotic binding site [chemical binding]; other site 317936007303 Uncharacterized conserved protein [Function unknown]; Region: COG2361 317936007304 S-layer homology domain; Region: SLH; pfam00395 317936007305 S-layer homology domain; Region: SLH; pfam00395 317936007306 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 317936007307 Fasciclin domain; Region: Fasciclin; pfam02469 317936007308 Permease; Region: Permease; cl00510 317936007309 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 317936007310 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 317936007311 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007313 active site 317936007314 phosphorylation site [posttranslational modification] 317936007315 intermolecular recognition site; other site 317936007316 dimerization interface [polypeptide binding]; other site 317936007317 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 317936007318 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 317936007319 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936007320 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 317936007321 anti sigma factor interaction site; other site 317936007322 regulatory phosphorylation site [posttranslational modification]; other site 317936007323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936007324 non-specific DNA binding site [nucleotide binding]; other site 317936007325 salt bridge; other site 317936007326 sequence-specific DNA binding site [nucleotide binding]; other site 317936007327 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 317936007328 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 317936007329 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 317936007330 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 317936007331 dimerization interface [polypeptide binding]; other site 317936007332 DPS ferroxidase diiron center [ion binding]; other site 317936007333 ion pore; other site 317936007334 ParB-like nuclease domain; Region: ParBc; cl02129 317936007335 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 317936007336 Stage II sporulation protein; Region: SpoIID; pfam08486 317936007337 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936007338 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936007339 catalytic loop [active] 317936007340 iron binding site [ion binding]; other site 317936007341 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936007342 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936007343 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 317936007344 active site 317936007345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936007346 dimerization interface [polypeptide binding]; other site 317936007347 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936007348 cyclase homology domain; Region: CHD; cd07302 317936007349 nucleotidyl binding site; other site 317936007350 metal binding site [ion binding]; metal-binding site 317936007351 dimer interface [polypeptide binding]; other site 317936007352 metal coordination site [ion binding]; other site 317936007353 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 317936007354 Moco binding site; other site 317936007355 Proline dehydrogenase; Region: Pro_dh; pfam01619 317936007356 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 317936007357 delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237 317936007358 Glutamate binding site [chemical binding]; other site 317936007359 homodimer interface [polypeptide binding]; other site 317936007360 NAD binding site [chemical binding]; other site 317936007361 catalytic residues [active] 317936007362 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 317936007363 Family description; Region: UvrD_C_2; pfam13538 317936007364 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936007365 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007367 active site 317936007368 phosphorylation site [posttranslational modification] 317936007369 intermolecular recognition site; other site 317936007370 dimerization interface [polypeptide binding]; other site 317936007371 GAF domain; Region: GAF; pfam01590 317936007372 GAF domain; Region: GAF_2; pfam13185 317936007373 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 317936007374 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936007375 S-adenosylmethionine binding site [chemical binding]; other site 317936007376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 317936007377 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 317936007378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 317936007379 Zn2+ binding site [ion binding]; other site 317936007380 Mg2+ binding site [ion binding]; other site 317936007381 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 317936007382 Dehydroquinase class II; Region: DHquinase_II; pfam01220 317936007383 trimer interface [polypeptide binding]; other site 317936007384 active site 317936007385 dimer interface [polypeptide binding]; other site 317936007386 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 317936007387 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 317936007388 active site 317936007389 interdomain interaction site; other site 317936007390 putative metal-binding site [ion binding]; other site 317936007391 nucleotide binding site [chemical binding]; other site 317936007392 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 317936007393 domain I; other site 317936007394 phosphate binding site [ion binding]; other site 317936007395 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 317936007396 domain II; other site 317936007397 domain III; other site 317936007398 nucleotide binding site [chemical binding]; other site 317936007399 DNA binding groove [nucleotide binding] 317936007400 catalytic site [active] 317936007401 domain IV; other site 317936007402 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 317936007403 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 317936007404 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 317936007405 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 317936007406 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 317936007407 DNA methylase; Region: N6_N4_Mtase; pfam01555 317936007408 sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828 317936007409 active site 317936007410 catalytic triad [active] 317936007411 oxyanion hole [active] 317936007412 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 317936007413 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 317936007414 Ligand Binding Site [chemical binding]; other site 317936007415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936007416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936007417 dimer interface [polypeptide binding]; other site 317936007418 phosphorylation site [posttranslational modification] 317936007419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936007420 ATP binding site [chemical binding]; other site 317936007421 Mg2+ binding site [ion binding]; other site 317936007422 G-X-G motif; other site 317936007423 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007425 active site 317936007426 phosphorylation site [posttranslational modification] 317936007427 intermolecular recognition site; other site 317936007428 dimerization interface [polypeptide binding]; other site 317936007429 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 317936007430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 317936007431 TM-ABC transporter signature motif; other site 317936007432 PsaX family; Region: PsaX; pfam08078 317936007433 lipoyl synthase; Provisional; Region: PRK12928 317936007434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936007435 FeS/SAM binding site; other site 317936007436 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007438 active site 317936007439 phosphorylation site [posttranslational modification] 317936007440 intermolecular recognition site; other site 317936007441 dimerization interface [polypeptide binding]; other site 317936007442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936007443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936007444 active site 317936007445 ATP binding site [chemical binding]; other site 317936007446 substrate binding site [chemical binding]; other site 317936007447 substrate binding site [chemical binding]; other site 317936007448 activation loop (A-loop); other site 317936007449 activation loop (A-loop); other site 317936007450 AAA ATPase domain; Region: AAA_16; pfam13191 317936007451 Predicted ATPase [General function prediction only]; Region: COG3899 317936007452 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936007453 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936007454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936007455 dimer interface [polypeptide binding]; other site 317936007456 phosphorylation site [posttranslational modification] 317936007457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936007458 ATP binding site [chemical binding]; other site 317936007459 Mg2+ binding site [ion binding]; other site 317936007460 G-X-G motif; other site 317936007461 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 317936007462 intersubunit interface [polypeptide binding]; other site 317936007463 active site 317936007464 catalytic residue [active] 317936007465 Recombination protein O N terminal; Region: RecO_N; pfam11967 317936007466 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 317936007467 Recombination protein O C terminal; Region: RecO_C; pfam02565 317936007468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936007469 H+ Antiporter protein; Region: 2A0121; TIGR00900 317936007470 putative substrate translocation pore; other site 317936007471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936007472 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936007473 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 317936007474 active site 317936007475 Preprotein translocase SecG subunit; Region: SecG; cl09123 317936007476 phosphoglyceromutase; Provisional; Region: PRK05434 317936007477 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 317936007478 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 317936007479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936007480 Walker A/P-loop; other site 317936007481 ATP binding site [chemical binding]; other site 317936007482 Q-loop/lid; other site 317936007483 ABC transporter signature motif; other site 317936007484 Walker B; other site 317936007485 D-loop; other site 317936007486 H-loop/switch region; other site 317936007487 ABC transporter; Region: ABC_tran_2; pfam12848 317936007488 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 317936007489 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936007490 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936007491 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936007492 peptide chain release factor 1; Validated; Region: prfA; PRK00591 317936007493 This domain is found in peptide chain release factors; Region: PCRF; smart00937 317936007494 RF-1 domain; Region: RF-1; pfam00472 317936007495 ribosomal protein L31; Validated; Region: rpl31; CHL00136 317936007496 ribosomal protein S9; Region: rps9; CHL00079 317936007497 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 317936007498 23S rRNA interface [nucleotide binding]; other site 317936007499 L3 interface [polypeptide binding]; other site 317936007500 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 317936007501 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 317936007502 dimerization interface 3.5A [polypeptide binding]; other site 317936007503 active site 317936007504 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 317936007505 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 317936007506 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 317936007507 alphaNTD - beta interaction site [polypeptide binding]; other site 317936007508 alphaNTD homodimer interface [polypeptide binding]; other site 317936007509 alphaNTD - beta' interaction site [polypeptide binding]; other site 317936007510 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 317936007511 30S ribosomal protein S11; Validated; Region: PRK05309 317936007512 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 317936007513 30S ribosomal protein S13; Region: bact_S13; TIGR03631 317936007514 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 317936007515 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 317936007516 rRNA binding site [nucleotide binding]; other site 317936007517 predicted 30S ribosome binding site; other site 317936007518 adenylate kinase; Provisional; Region: adk; PRK02496 317936007519 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 317936007520 AMP-binding site [chemical binding]; other site 317936007521 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 317936007522 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 317936007523 SecY translocase; Region: SecY; pfam00344 317936007524 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 317936007525 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 317936007526 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 317936007527 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 317936007528 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 317936007529 5S rRNA interface [nucleotide binding]; other site 317936007530 L27 interface [polypeptide binding]; other site 317936007531 23S rRNA interface [nucleotide binding]; other site 317936007532 L5 interface [polypeptide binding]; other site 317936007533 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 317936007534 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 317936007535 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 317936007536 ribosomal protein S8; Region: rps8; CHL00042 317936007537 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 317936007538 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 317936007539 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 317936007540 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 317936007541 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 317936007542 RNA binding site [nucleotide binding]; other site 317936007543 ribosomal protein L14; Region: rpl14; CHL00057 317936007544 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 317936007545 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 317936007546 23S rRNA interface [nucleotide binding]; other site 317936007547 putative translocon interaction site; other site 317936007548 signal recognition particle (SRP54) interaction site; other site 317936007549 L23 interface [polypeptide binding]; other site 317936007550 trigger factor interaction site; other site 317936007551 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 317936007552 23S rRNA interface [nucleotide binding]; other site 317936007553 5S rRNA interface [nucleotide binding]; other site 317936007554 putative antibiotic binding site [chemical binding]; other site 317936007555 L25 interface [polypeptide binding]; other site 317936007556 L27 interface [polypeptide binding]; other site 317936007557 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 317936007558 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 317936007559 G-X-X-G motif; other site 317936007560 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 317936007561 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 317936007562 putative translocon binding site; other site 317936007563 protein-rRNA interface [nucleotide binding]; other site 317936007564 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 317936007565 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 317936007566 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 317936007567 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 317936007568 ribosomal protein L23; Region: rpl23; CHL00030 317936007569 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 317936007570 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 317936007571 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 317936007572 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 317936007573 dimer interface [polypeptide binding]; other site 317936007574 ADP-ribose binding site [chemical binding]; other site 317936007575 active site 317936007576 nudix motif; other site 317936007577 metal binding site [ion binding]; metal-binding site 317936007578 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 317936007579 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 317936007580 active site 317936007581 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 317936007582 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 317936007583 metal binding site 2 [ion binding]; metal-binding site 317936007584 putative DNA binding helix; other site 317936007585 metal binding site 1 [ion binding]; metal-binding site 317936007586 dimer interface [polypeptide binding]; other site 317936007587 structural Zn2+ binding site [ion binding]; other site 317936007588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936007589 binding surface 317936007590 TPR motif; other site 317936007591 Peptidase family M48; Region: Peptidase_M48; pfam01435 317936007592 Circadian oscillating protein COP23; Region: COP23; pfam14218 317936007593 Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131 317936007594 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 317936007595 NAD binding site [chemical binding]; other site 317936007596 catalytic residues [active] 317936007597 Protein kinase domain; Region: Pkinase; pfam00069 317936007598 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936007599 active site 317936007600 ATP binding site [chemical binding]; other site 317936007601 substrate binding site [chemical binding]; other site 317936007602 activation loop (A-loop); other site 317936007603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007604 TPR repeat; Region: TPR_11; pfam13414 317936007605 binding surface 317936007606 TPR motif; other site 317936007607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007608 binding surface 317936007609 TPR motif; other site 317936007610 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936007611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007612 binding surface 317936007613 TPR motif; other site 317936007614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007615 binding surface 317936007616 TPR motif; other site 317936007617 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936007618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936007619 PAS fold; Region: PAS_3; pfam08447 317936007620 putative active site [active] 317936007621 heme pocket [chemical binding]; other site 317936007622 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936007623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936007624 putative active site [active] 317936007625 heme pocket [chemical binding]; other site 317936007626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936007627 putative active site [active] 317936007628 heme pocket [chemical binding]; other site 317936007629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936007630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936007631 dimer interface [polypeptide binding]; other site 317936007632 phosphorylation site [posttranslational modification] 317936007633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936007634 ATP binding site [chemical binding]; other site 317936007635 Mg2+ binding site [ion binding]; other site 317936007636 G-X-G motif; other site 317936007637 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936007638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007639 active site 317936007640 phosphorylation site [posttranslational modification] 317936007641 intermolecular recognition site; other site 317936007642 dimerization interface [polypeptide binding]; other site 317936007643 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 317936007644 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 317936007645 HIGH motif; other site 317936007646 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 317936007647 active site 317936007648 KMSKS motif; other site 317936007649 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936007650 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936007651 active site 317936007652 ATP binding site [chemical binding]; other site 317936007653 substrate binding site [chemical binding]; other site 317936007654 activation loop (A-loop); other site 317936007655 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936007656 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936007657 active site 317936007658 ATP binding site [chemical binding]; other site 317936007659 substrate binding site [chemical binding]; other site 317936007660 activation loop (A-loop); other site 317936007661 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 317936007662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 317936007663 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 317936007664 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 317936007665 RNase_H superfamily; Region: RNase_H_2; pfam13482 317936007666 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 317936007667 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936007668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936007669 catalytic residue [active] 317936007670 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 317936007671 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936007672 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 317936007673 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 317936007674 putative active site [active] 317936007675 catalytic triad [active] 317936007676 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 317936007677 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 317936007678 metal binding site 2 [ion binding]; metal-binding site 317936007679 putative DNA binding helix; other site 317936007680 metal binding site 1 [ion binding]; metal-binding site 317936007681 dimer interface [polypeptide binding]; other site 317936007682 structural Zn2+ binding site [ion binding]; other site 317936007683 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 317936007684 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 317936007685 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 317936007686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936007687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007688 active site 317936007689 phosphorylation site [posttranslational modification] 317936007690 intermolecular recognition site; other site 317936007691 dimerization interface [polypeptide binding]; other site 317936007692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936007693 DNA binding site [nucleotide binding] 317936007694 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936007695 putative binding surface; other site 317936007696 active site 317936007697 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007699 active site 317936007700 phosphorylation site [posttranslational modification] 317936007701 intermolecular recognition site; other site 317936007702 dimerization interface [polypeptide binding]; other site 317936007703 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007705 active site 317936007706 phosphorylation site [posttranslational modification] 317936007707 intermolecular recognition site; other site 317936007708 dimerization interface [polypeptide binding]; other site 317936007709 PAS domain S-box; Region: sensory_box; TIGR00229 317936007710 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936007711 putative active site [active] 317936007712 heme pocket [chemical binding]; other site 317936007713 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936007714 GAF domain; Region: GAF; pfam01590 317936007715 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936007716 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936007717 putative active site [active] 317936007718 heme pocket [chemical binding]; other site 317936007719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936007720 dimer interface [polypeptide binding]; other site 317936007721 phosphorylation site [posttranslational modification] 317936007722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936007723 ATP binding site [chemical binding]; other site 317936007724 Mg2+ binding site [ion binding]; other site 317936007725 G-X-G motif; other site 317936007726 Response regulator receiver domain; Region: Response_reg; pfam00072 317936007727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007728 active site 317936007729 phosphorylation site [posttranslational modification] 317936007730 intermolecular recognition site; other site 317936007731 dimerization interface [polypeptide binding]; other site 317936007732 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936007733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007734 active site 317936007735 phosphorylation site [posttranslational modification] 317936007736 intermolecular recognition site; other site 317936007737 dimerization interface [polypeptide binding]; other site 317936007738 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936007739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007740 active site 317936007741 phosphorylation site [posttranslational modification] 317936007742 intermolecular recognition site; other site 317936007743 dimerization interface [polypeptide binding]; other site 317936007744 CHAT domain; Region: CHAT; cl17868 317936007745 AAA ATPase domain; Region: AAA_16; pfam13191 317936007746 AAA domain; Region: AAA_22; pfam13401 317936007747 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007748 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007751 binding surface 317936007752 TPR motif; other site 317936007753 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007754 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936007755 binding surface 317936007756 TPR motif; other site 317936007757 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007758 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936007759 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 317936007760 Uncharacterized conserved protein [Function unknown]; Region: COG2361 317936007761 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 317936007762 active site 317936007763 NTP binding site [chemical binding]; other site 317936007764 metal binding triad [ion binding]; metal-binding site 317936007765 antibiotic binding site [chemical binding]; other site 317936007766 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 317936007767 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 317936007768 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 317936007769 DNA polymerase III subunit alpha; Reviewed; Region: PRK09532 317936007770 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 317936007771 active site 317936007772 PHP Thumb interface [polypeptide binding]; other site 317936007773 metal binding site [ion binding]; metal-binding site 317936007774 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936007775 protein-splicing catalytic site; other site 317936007776 thioester formation/cholesterol transfer; other site 317936007777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936007778 non-specific DNA binding site [nucleotide binding]; other site 317936007779 salt bridge; other site 317936007780 sequence-specific DNA binding site [nucleotide binding]; other site 317936007781 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 317936007782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936007783 DNA methylase; Region: N6_N4_Mtase; pfam01555 317936007784 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 317936007785 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 317936007786 Permease; Region: Permease; cl00510 317936007787 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 317936007788 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 317936007789 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 317936007790 tandem repeat interface [polypeptide binding]; other site 317936007791 oligomer interface [polypeptide binding]; other site 317936007792 active site residues [active] 317936007793 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 317936007794 homotrimer interaction site [polypeptide binding]; other site 317936007795 active site 317936007796 PBP superfamily domain; Region: PBP_like_2; pfam12849 317936007797 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936007798 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936007799 active site 317936007800 ATP binding site [chemical binding]; other site 317936007801 substrate binding site [chemical binding]; other site 317936007802 activation loop (A-loop); other site 317936007803 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 317936007804 Fatty acid desaturase; Region: FA_desaturase; pfam00487 317936007805 putative di-iron ligands [ion binding]; other site 317936007806 pyruvate kinase; Provisional; Region: PRK06354 317936007807 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 317936007808 domain interfaces; other site 317936007809 active site 317936007810 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 317936007811 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936007812 putative active site [active] 317936007813 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936007814 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 317936007815 P-loop; other site 317936007816 Magnesium ion binding site [ion binding]; other site 317936007817 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936007818 Magnesium ion binding site [ion binding]; other site 317936007819 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 317936007820 MutS domain III; Region: MutS_III; pfam05192 317936007821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936007822 Walker A/P-loop; other site 317936007823 ATP binding site [chemical binding]; other site 317936007824 Q-loop/lid; other site 317936007825 ABC transporter signature motif; other site 317936007826 Walker B; other site 317936007827 D-loop; other site 317936007828 H-loop/switch region; other site 317936007829 Smr domain; Region: Smr; pfam01713 317936007830 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 317936007831 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 317936007832 active site 317936007833 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936007834 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936007835 catalytic residues [active] 317936007836 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 317936007837 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 317936007838 active site 317936007839 dimer interface [polypeptide binding]; other site 317936007840 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 317936007841 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 317936007842 active site 317936007843 FMN binding site [chemical binding]; other site 317936007844 substrate binding site [chemical binding]; other site 317936007845 3Fe-4S cluster binding site [ion binding]; other site 317936007846 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 317936007847 domain interface; other site 317936007848 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 317936007849 Cupin domain; Region: Cupin_2; cl17218 317936007850 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 317936007851 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 317936007852 S17 interaction site [polypeptide binding]; other site 317936007853 S8 interaction site; other site 317936007854 16S rRNA interaction site [nucleotide binding]; other site 317936007855 streptomycin interaction site [chemical binding]; other site 317936007856 23S rRNA interaction site [nucleotide binding]; other site 317936007857 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 317936007858 30S ribosomal protein S7; Validated; Region: PRK05302 317936007859 elongation factor G; Reviewed; Region: PRK00007 317936007860 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 317936007861 G1 box; other site 317936007862 putative GEF interaction site [polypeptide binding]; other site 317936007863 GTP/Mg2+ binding site [chemical binding]; other site 317936007864 Switch I region; other site 317936007865 G2 box; other site 317936007866 G3 box; other site 317936007867 Switch II region; other site 317936007868 G4 box; other site 317936007869 G5 box; other site 317936007870 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 317936007871 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 317936007872 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 317936007873 elongation factor Tu; Region: tufA; CHL00071 317936007874 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 317936007875 G1 box; other site 317936007876 GEF interaction site [polypeptide binding]; other site 317936007877 GTP/Mg2+ binding site [chemical binding]; other site 317936007878 Switch I region; other site 317936007879 G2 box; other site 317936007880 G3 box; other site 317936007881 Switch II region; other site 317936007882 G4 box; other site 317936007883 G5 box; other site 317936007884 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 317936007885 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 317936007886 Antibiotic Binding Site [chemical binding]; other site 317936007887 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 317936007888 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 317936007889 prephenate dehydratase; Provisional; Region: PRK11898 317936007890 Prephenate dehydratase; Region: PDT; pfam00800 317936007891 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 317936007892 putative L-Phe binding site [chemical binding]; other site 317936007893 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 317936007894 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 317936007895 RNA/DNA hybrid binding site [nucleotide binding]; other site 317936007896 active site 317936007897 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 317936007898 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 317936007899 homodimer interface [polypeptide binding]; other site 317936007900 oligonucleotide binding site [chemical binding]; other site 317936007901 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 317936007902 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 317936007903 B12 binding site [chemical binding]; other site 317936007904 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936007905 FeS/SAM binding site; other site 317936007906 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 317936007907 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 317936007908 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936007909 anti sigma factor interaction site; other site 317936007910 regulatory phosphorylation site [posttranslational modification]; other site 317936007911 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 317936007912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936007913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936007914 homodimer interface [polypeptide binding]; other site 317936007915 catalytic residue [active] 317936007916 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936007917 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 317936007918 CAAX protease self-immunity; Region: Abi; pfam02517 317936007919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936007920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936007921 active site 317936007922 ATP binding site [chemical binding]; other site 317936007923 substrate binding site [chemical binding]; other site 317936007924 activation loop (A-loop); other site 317936007925 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936007926 structural tetrad; other site 317936007927 PQQ-like domain; Region: PQQ_2; pfam13360 317936007928 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 317936007929 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936007930 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936007931 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936007932 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936007933 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936007934 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936007935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936007936 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936007937 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936007938 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731 317936007939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 317936007940 Zn2+ binding site [ion binding]; other site 317936007941 Mg2+ binding site [ion binding]; other site 317936007942 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 317936007943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936007944 FeS/SAM binding site; other site 317936007945 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 317936007946 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 317936007947 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 317936007948 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 317936007949 Walker A/P-loop; other site 317936007950 ATP binding site [chemical binding]; other site 317936007951 Q-loop/lid; other site 317936007952 ABC transporter signature motif; other site 317936007953 Walker B; other site 317936007954 D-loop; other site 317936007955 H-loop/switch region; other site 317936007956 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936007957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936007958 active site 317936007959 phosphorylation site [posttranslational modification] 317936007960 intermolecular recognition site; other site 317936007961 dimerization interface [polypeptide binding]; other site 317936007962 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936007963 DNA binding site [nucleotide binding] 317936007964 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 317936007965 putative GSH binding site [chemical binding]; other site 317936007966 catalytic residues [active] 317936007967 BolA-like protein; Region: BolA; pfam01722 317936007968 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 317936007969 Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498 317936007970 active site 317936007971 catalytic triad [active] 317936007972 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 317936007973 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 317936007974 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 317936007975 putative acyl-acceptor binding pocket; other site 317936007976 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 317936007977 nucleoside/Zn binding site; other site 317936007978 dimer interface [polypeptide binding]; other site 317936007979 catalytic motif [active] 317936007980 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 317936007981 transketolase; Region: PLN02790 317936007982 TPP-binding site [chemical binding]; other site 317936007983 dimer interface [polypeptide binding]; other site 317936007984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 317936007985 PYR/PP interface [polypeptide binding]; other site 317936007986 dimer interface [polypeptide binding]; other site 317936007987 TPP binding site [chemical binding]; other site 317936007988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 317936007989 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 317936007990 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 317936007991 dimer interface [polypeptide binding]; other site 317936007992 active site 317936007993 acyl carrier protein; Provisional; Region: acpP; PRK00982 317936007994 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 317936007995 Cysteine-rich domain; Region: CCG; pfam02754 317936007996 Cysteine-rich domain; Region: CCG; pfam02754 317936007997 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 317936007998 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 317936007999 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 317936008000 trimer interface [polypeptide binding]; other site 317936008001 active site 317936008002 UDP-GlcNAc binding site [chemical binding]; other site 317936008003 lipid binding site [chemical binding]; lipid-binding site 317936008004 flavoprotein, HI0933 family; Region: TIGR00275 317936008005 Rubredoxin [Energy production and conversion]; Region: COG1773 317936008006 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 317936008007 iron binding site [ion binding]; other site 317936008008 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 317936008009 hydrophobic ligand binding site; other site 317936008010 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 317936008011 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936008012 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936008013 Cytochrome P450; Region: p450; pfam00067 317936008014 Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957 317936008015 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 317936008016 TPP-binding site [chemical binding]; other site 317936008017 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 317936008018 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 317936008019 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 317936008020 C-terminal domain interface [polypeptide binding]; other site 317936008021 active site 317936008022 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 317936008023 active site 317936008024 N-terminal domain interface [polypeptide binding]; other site 317936008025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936008026 H+ Antiporter protein; Region: 2A0121; TIGR00900 317936008027 putative substrate translocation pore; other site 317936008028 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 317936008029 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 317936008030 PYR/PP interface [polypeptide binding]; other site 317936008031 dimer interface [polypeptide binding]; other site 317936008032 TPP binding site [chemical binding]; other site 317936008033 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 317936008034 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 317936008035 TPP-binding site [chemical binding]; other site 317936008036 dimer interface [polypeptide binding]; other site 317936008037 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 317936008038 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 317936008039 proposed catalytic triad [active] 317936008040 active site nucleophile [active] 317936008041 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936008042 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936008043 GTP-binding protein LepA; Provisional; Region: PRK05433 317936008044 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 317936008045 G1 box; other site 317936008046 putative GEF interaction site [polypeptide binding]; other site 317936008047 GTP/Mg2+ binding site [chemical binding]; other site 317936008048 Switch I region; other site 317936008049 G2 box; other site 317936008050 G3 box; other site 317936008051 Switch II region; other site 317936008052 G4 box; other site 317936008053 G5 box; other site 317936008054 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 317936008055 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 317936008056 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 317936008057 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008058 GAF domain; Region: GAF_3; pfam13492 317936008059 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008060 dimer interface [polypeptide binding]; other site 317936008061 phosphorylation site [posttranslational modification] 317936008062 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008063 ATP binding site [chemical binding]; other site 317936008064 Mg2+ binding site [ion binding]; other site 317936008065 G-X-G motif; other site 317936008066 NifU-like domain; Region: NifU; pfam01106 317936008067 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 317936008068 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 317936008069 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 317936008070 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 317936008071 putative active site [active] 317936008072 catalytic site [active] 317936008073 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 317936008074 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936008075 active site 317936008076 ATP binding site [chemical binding]; other site 317936008077 substrate binding site [chemical binding]; other site 317936008078 activation loop (A-loop); other site 317936008079 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 317936008080 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936008081 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936008082 metal binding site [ion binding]; metal-binding site 317936008083 active site 317936008084 I-site; other site 317936008085 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936008086 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936008087 metal binding site [ion binding]; metal-binding site 317936008088 active site 317936008089 I-site; other site 317936008090 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 317936008091 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 317936008092 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 317936008093 catalytic triad [active] 317936008094 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 317936008095 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 317936008096 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 317936008097 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 317936008098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936008099 Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429 317936008100 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 317936008101 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 317936008102 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 317936008103 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 317936008104 putative active site [active] 317936008105 transaldolase; Provisional; Region: PRK03903 317936008106 catalytic residue [active] 317936008107 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 317936008108 AMP binding site [chemical binding]; other site 317936008109 metal binding site [ion binding]; metal-binding site 317936008110 active site 317936008111 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936008112 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 317936008113 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 317936008114 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936008115 protein-splicing catalytic site; other site 317936008116 thioester formation/cholesterol transfer; other site 317936008117 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936008118 protein-splicing catalytic site; other site 317936008119 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 317936008120 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 317936008121 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766 317936008122 Transposase IS200 like; Region: Y1_Tnp; pfam01797 317936008123 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 317936008124 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 317936008125 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 317936008126 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 317936008127 trimer interface [polypeptide binding]; other site 317936008128 active site 317936008129 substrate binding site [chemical binding]; other site 317936008130 CoA binding site [chemical binding]; other site 317936008131 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 317936008132 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 317936008133 Uncharacterized conserved protein [Function unknown]; Region: COG1565 317936008134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 317936008135 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936008136 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936008137 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 317936008138 DNA binding residues [nucleotide binding] 317936008139 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 317936008140 dimer interface [polypeptide binding]; other site 317936008141 metal binding site [ion binding]; metal-binding site 317936008142 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936008143 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008144 putative active site [active] 317936008145 heme pocket [chemical binding]; other site 317936008146 PAS domain; Region: PAS; smart00091 317936008147 putative active site [active] 317936008148 heme pocket [chemical binding]; other site 317936008149 PAS domain S-box; Region: sensory_box; TIGR00229 317936008150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008151 putative active site [active] 317936008152 heme pocket [chemical binding]; other site 317936008153 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008154 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008157 ATP binding site [chemical binding]; other site 317936008158 Mg2+ binding site [ion binding]; other site 317936008159 G-X-G motif; other site 317936008160 PAS domain S-box; Region: sensory_box; TIGR00229 317936008161 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008162 putative active site [active] 317936008163 heme pocket [chemical binding]; other site 317936008164 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936008165 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008166 putative active site [active] 317936008167 heme pocket [chemical binding]; other site 317936008168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008169 dimer interface [polypeptide binding]; other site 317936008170 phosphorylation site [posttranslational modification] 317936008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008172 ATP binding site [chemical binding]; other site 317936008173 Mg2+ binding site [ion binding]; other site 317936008174 G-X-G motif; other site 317936008175 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 317936008176 bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424 317936008177 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 317936008178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936008179 NAD(P) binding site [chemical binding]; other site 317936008180 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 317936008181 putative active site [active] 317936008182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936008183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008184 active site 317936008185 phosphorylation site [posttranslational modification] 317936008186 intermolecular recognition site; other site 317936008187 dimerization interface [polypeptide binding]; other site 317936008188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936008189 DNA binding site [nucleotide binding] 317936008190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008192 dimerization interface [polypeptide binding]; other site 317936008193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008194 dimer interface [polypeptide binding]; other site 317936008195 phosphorylation site [posttranslational modification] 317936008196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008197 ATP binding site [chemical binding]; other site 317936008198 Mg2+ binding site [ion binding]; other site 317936008199 G-X-G motif; other site 317936008200 TPR repeat; Region: TPR_11; pfam13414 317936008201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008202 binding surface 317936008203 TPR motif; other site 317936008204 TPR repeat; Region: TPR_11; pfam13414 317936008205 TPR repeat; Region: TPR_11; pfam13414 317936008206 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008207 binding surface 317936008208 TPR motif; other site 317936008209 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936008210 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 317936008211 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 317936008212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 317936008213 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 317936008214 B12 binding domain; Region: B12-binding; pfam02310 317936008215 B12 binding site [chemical binding]; other site 317936008216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936008217 FeS/SAM binding site; other site 317936008218 Domain of unknown function (DUF4070); Region: DUF4070; pfam13282 317936008219 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008220 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936008221 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936008222 DNA binding residues [nucleotide binding] 317936008223 dimerization interface [polypeptide binding]; other site 317936008224 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 317936008225 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 317936008226 active site residue [active] 317936008227 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 317936008228 active site residue [active] 317936008229 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 317936008230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936008231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936008232 active site 317936008233 ATP binding site [chemical binding]; other site 317936008234 substrate binding site [chemical binding]; other site 317936008235 activation loop (A-loop); other site 317936008236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936008237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936008238 active site 317936008239 ATP binding site [chemical binding]; other site 317936008240 substrate binding site [chemical binding]; other site 317936008241 activation loop (A-loop); other site 317936008242 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 317936008243 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 317936008244 acyl-activating enzyme (AAE) consensus motif; other site 317936008245 CoA binding site [chemical binding]; other site 317936008246 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936008247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936008248 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 317936008249 ABC1 family; Region: ABC1; cl17513 317936008250 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 317936008251 active site 317936008252 Phycobilisome degradation protein nblA; Region: NblA; pfam04485 317936008253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936008254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936008255 active site 317936008256 ATP binding site [chemical binding]; other site 317936008257 substrate binding site [chemical binding]; other site 317936008258 activation loop (A-loop); other site 317936008259 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 317936008260 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 317936008261 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 317936008262 active site 317936008263 catalytic site [active] 317936008264 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 317936008265 calcium/proton exchanger (cax); Region: cax; TIGR00378 317936008266 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 317936008267 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936008268 sucrose synthase; Region: sucr_synth; TIGR02470 317936008269 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 317936008270 putative ADP-binding pocket [chemical binding]; other site 317936008271 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 317936008272 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 317936008273 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 317936008274 putative active site [active] 317936008275 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 317936008276 putative active site [active] 317936008277 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 317936008278 active site 317936008279 SAM binding site [chemical binding]; other site 317936008280 homodimer interface [polypeptide binding]; other site 317936008281 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936008282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936008283 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 317936008284 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936008285 Predicted membrane protein [Function unknown]; Region: COG3431 317936008286 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936008287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936008288 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936008289 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 317936008290 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 317936008291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936008292 catalytic residue [active] 317936008293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008295 binding surface 317936008296 TPR motif; other site 317936008297 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008299 binding surface 317936008300 TPR motif; other site 317936008301 TPR repeat; Region: TPR_11; pfam13414 317936008302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008304 binding surface 317936008305 TPR motif; other site 317936008306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008307 TPR repeat; Region: TPR_11; pfam13414 317936008308 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008309 binding surface 317936008310 TPR motif; other site 317936008311 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008314 binding surface 317936008315 TPR motif; other site 317936008316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936008317 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936008318 Ligand Binding Site [chemical binding]; other site 317936008319 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936008320 Ligand Binding Site [chemical binding]; other site 317936008321 photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989 317936008322 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936008323 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936008324 catalytic loop [active] 317936008325 iron binding site [ion binding]; other site 317936008326 Predicted membrane protein [Function unknown]; Region: COG1950 317936008327 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 317936008328 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 317936008329 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 317936008330 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936008331 S-adenosylmethionine binding site [chemical binding]; other site 317936008332 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 317936008333 AAA ATPase domain; Region: AAA_16; pfam13191 317936008334 NACHT domain; Region: NACHT; pfam05729 317936008335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008336 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008337 TPR motif; other site 317936008338 binding surface 317936008339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008340 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936008341 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936008342 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936008343 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 317936008344 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 317936008345 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 317936008346 catalytic residue [active] 317936008347 putative FPP diphosphate binding site; other site 317936008348 putative FPP binding hydrophobic cleft; other site 317936008349 dimer interface [polypeptide binding]; other site 317936008350 putative IPP diphosphate binding site; other site 317936008351 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 317936008352 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 317936008353 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 317936008354 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 317936008355 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 317936008356 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 317936008357 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 317936008358 XisI protein; Region: XisI; pfam08869 317936008359 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 317936008360 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 317936008361 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 317936008362 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 317936008363 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936008364 oligomeric interface; other site 317936008365 putative active site [active] 317936008366 homodimer interface [polypeptide binding]; other site 317936008367 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 317936008368 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 317936008369 putative active site [active] 317936008370 putative NTP binding site [chemical binding]; other site 317936008371 putative nucleic acid binding site [nucleotide binding]; other site 317936008372 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 317936008373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936008374 non-specific DNA binding site [nucleotide binding]; other site 317936008375 salt bridge; other site 317936008376 sequence-specific DNA binding site [nucleotide binding]; other site 317936008377 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 317936008378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008379 TPR motif; other site 317936008380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008381 binding surface 317936008382 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008384 Tetratricopeptide repeat; Region: TPR_10; pfam13374 317936008385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008387 binding surface 317936008388 TPR motif; other site 317936008389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008390 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008392 binding surface 317936008393 TPR motif; other site 317936008394 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008396 binding surface 317936008397 TPR motif; other site 317936008398 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008400 binding surface 317936008401 TPR motif; other site 317936008402 CHAT domain; Region: CHAT; pfam12770 317936008403 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 317936008404 MoaE homodimer interface [polypeptide binding]; other site 317936008405 MoaD interaction [polypeptide binding]; other site 317936008406 active site residues [active] 317936008407 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008409 active site 317936008410 phosphorylation site [posttranslational modification] 317936008411 intermolecular recognition site; other site 317936008412 dimerization interface [polypeptide binding]; other site 317936008413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008414 PAS fold; Region: PAS_3; pfam08447 317936008415 putative active site [active] 317936008416 heme pocket [chemical binding]; other site 317936008417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008418 PAS fold; Region: PAS_3; pfam08447 317936008419 putative active site [active] 317936008420 heme pocket [chemical binding]; other site 317936008421 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008422 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008424 dimer interface [polypeptide binding]; other site 317936008425 phosphorylation site [posttranslational modification] 317936008426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008427 ATP binding site [chemical binding]; other site 317936008428 Mg2+ binding site [ion binding]; other site 317936008429 G-X-G motif; other site 317936008430 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008432 active site 317936008433 phosphorylation site [posttranslational modification] 317936008434 intermolecular recognition site; other site 317936008435 dimerization interface [polypeptide binding]; other site 317936008436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008437 active site 317936008438 phosphorylation site [posttranslational modification] 317936008439 intermolecular recognition site; other site 317936008440 dimerization interface [polypeptide binding]; other site 317936008441 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936008442 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008443 putative active site [active] 317936008444 heme pocket [chemical binding]; other site 317936008445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008446 dimer interface [polypeptide binding]; other site 317936008447 phosphorylation site [posttranslational modification] 317936008448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008449 ATP binding site [chemical binding]; other site 317936008450 Mg2+ binding site [ion binding]; other site 317936008451 G-X-G motif; other site 317936008452 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008454 active site 317936008455 phosphorylation site [posttranslational modification] 317936008456 intermolecular recognition site; other site 317936008457 dimerization interface [polypeptide binding]; other site 317936008458 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 317936008459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936008460 active site 317936008461 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 317936008462 Rrf2 family protein; Region: rrf2_super; TIGR00738 317936008463 Transcriptional regulator; Region: Rrf2; cl17282 317936008464 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 317936008465 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 317936008466 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 317936008467 Cl- selectivity filter; other site 317936008468 Cl- binding residues [ion binding]; other site 317936008469 pore gating glutamate residue; other site 317936008470 dimer interface [polypeptide binding]; other site 317936008471 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593 317936008472 FOG: CBS domain [General function prediction only]; Region: COG0517 317936008473 Phycobilisome protein; Region: Phycobilisome; cl08227 317936008474 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 317936008475 Fasciclin domain; Region: Fasciclin; pfam02469 317936008476 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 317936008477 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 317936008478 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 317936008479 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 317936008480 Cadmium resistance transporter; Region: Cad; pfam03596 317936008481 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 317936008482 Cadmium resistance transporter; Region: Cad; pfam03596 317936008483 Cadmium resistance transporter; Region: Cad; pfam03596 317936008484 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 317936008485 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 317936008486 dimer interface [polypeptide binding]; other site 317936008487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936008488 catalytic residue [active] 317936008489 Predicted transcriptional regulator [Transcription]; Region: COG1959 317936008490 Transcriptional regulator; Region: Rrf2; pfam02082 317936008491 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 317936008492 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 317936008493 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 317936008494 trimer interface [polypeptide binding]; other site 317936008495 active site 317936008496 substrate binding site [chemical binding]; other site 317936008497 CoA binding site [chemical binding]; other site 317936008498 Ferritin-like; Region: Ferritin-like; pfam12902 317936008499 CHAT domain; Region: CHAT; pfam12770 317936008500 AAA ATPase domain; Region: AAA_16; pfam13191 317936008501 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936008502 WD domain, G-beta repeat; Region: WD40; pfam00400 317936008503 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936008504 structural tetrad; other site 317936008505 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936008506 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936008507 structural tetrad; other site 317936008508 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936008509 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936008510 structural tetrad; other site 317936008511 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936008512 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936008513 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 317936008514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936008515 Walker A motif; other site 317936008516 ATP binding site [chemical binding]; other site 317936008517 Walker B motif; other site 317936008518 arginine finger; other site 317936008519 Peptidase family M41; Region: Peptidase_M41; pfam01434 317936008520 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 317936008521 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 317936008522 hinge; other site 317936008523 active site 317936008524 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 317936008525 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 317936008526 dimer interface [polypeptide binding]; other site 317936008527 motif 1; other site 317936008528 active site 317936008529 motif 2; other site 317936008530 motif 3; other site 317936008531 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 317936008532 anticodon binding site; other site 317936008533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936008534 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 317936008535 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 317936008536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 317936008537 Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302 317936008538 active site 317936008539 tetramer interface [polypeptide binding]; other site 317936008540 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 317936008541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 317936008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936008543 NAD(P) binding site [chemical binding]; other site 317936008544 active site 317936008545 SnoaL-like domain; Region: SnoaL_2; pfam12680 317936008546 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 317936008547 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 317936008548 putative acyl-acceptor binding pocket; other site 317936008549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936008550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008551 active site 317936008552 phosphorylation site [posttranslational modification] 317936008553 intermolecular recognition site; other site 317936008554 dimerization interface [polypeptide binding]; other site 317936008555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936008556 DNA binding site [nucleotide binding] 317936008557 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 317936008558 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 317936008559 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008560 GAF domain; Region: GAF; pfam01590 317936008561 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008562 PAS fold; Region: PAS_3; pfam08447 317936008563 putative active site [active] 317936008564 heme pocket [chemical binding]; other site 317936008565 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008566 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008568 dimer interface [polypeptide binding]; other site 317936008569 phosphorylation site [posttranslational modification] 317936008570 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 317936008571 Mg2+ binding site [ion binding]; other site 317936008572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008573 ATP binding site [chemical binding]; other site 317936008574 G-X-G motif; other site 317936008575 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008577 active site 317936008578 phosphorylation site [posttranslational modification] 317936008579 intermolecular recognition site; other site 317936008580 dimerization interface [polypeptide binding]; other site 317936008581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936008582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008583 active site 317936008584 phosphorylation site [posttranslational modification] 317936008585 intermolecular recognition site; other site 317936008586 dimerization interface [polypeptide binding]; other site 317936008587 PAS fold; Region: PAS_4; pfam08448 317936008588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008589 putative active site [active] 317936008590 heme pocket [chemical binding]; other site 317936008591 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936008592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936008593 putative active site [active] 317936008594 heme pocket [chemical binding]; other site 317936008595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008596 dimer interface [polypeptide binding]; other site 317936008597 phosphorylation site [posttranslational modification] 317936008598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008599 ATP binding site [chemical binding]; other site 317936008600 Mg2+ binding site [ion binding]; other site 317936008601 G-X-G motif; other site 317936008602 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008604 active site 317936008605 phosphorylation site [posttranslational modification] 317936008606 intermolecular recognition site; other site 317936008607 dimerization interface [polypeptide binding]; other site 317936008608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936008609 non-specific DNA binding site [nucleotide binding]; other site 317936008610 salt bridge; other site 317936008611 sequence-specific DNA binding site [nucleotide binding]; other site 317936008612 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 317936008613 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 317936008614 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 317936008615 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 317936008616 Uncharacterized conserved protein [Function unknown]; Region: COG1434 317936008617 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 317936008618 putative active site [active] 317936008619 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 317936008620 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 317936008621 MgtE intracellular N domain; Region: MgtE_N; smart00924 317936008622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 317936008623 Divalent cation transporter; Region: MgtE; pfam01769 317936008624 PemK-like protein; Region: PemK; pfam02452 317936008625 short chain dehydrogenase; Provisional; Region: PRK06197 317936008626 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 317936008627 putative NAD(P) binding site [chemical binding]; other site 317936008628 active site 317936008629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936008630 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936008631 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 317936008632 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 317936008633 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 317936008634 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936008635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936008636 S-adenosylmethionine binding site [chemical binding]; other site 317936008637 L-type amino acid transporter; Region: 2A0308; TIGR00911 317936008638 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008640 dimer interface [polypeptide binding]; other site 317936008641 phosphorylation site [posttranslational modification] 317936008642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008643 ATP binding site [chemical binding]; other site 317936008644 Mg2+ binding site [ion binding]; other site 317936008645 G-X-G motif; other site 317936008646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936008647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008648 active site 317936008649 phosphorylation site [posttranslational modification] 317936008650 intermolecular recognition site; other site 317936008651 dimerization interface [polypeptide binding]; other site 317936008652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936008653 DNA binding site [nucleotide binding] 317936008654 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 317936008655 Cache domain; Region: Cache_1; pfam02743 317936008656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008657 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008658 dimerization interface [polypeptide binding]; other site 317936008659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008660 dimer interface [polypeptide binding]; other site 317936008661 phosphorylation site [posttranslational modification] 317936008662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008663 ATP binding site [chemical binding]; other site 317936008664 Mg2+ binding site [ion binding]; other site 317936008665 G-X-G motif; other site 317936008666 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 317936008667 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 317936008668 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 317936008669 Zn binding site [ion binding]; other site 317936008670 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 317936008671 ABC1 family; Region: ABC1; cl17513 317936008672 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936008673 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936008674 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936008675 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 317936008676 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 317936008677 putative active site [active] 317936008678 putative metal binding site [ion binding]; other site 317936008679 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 317936008680 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 317936008681 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 317936008682 homodimer interface [polypeptide binding]; other site 317936008683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936008684 catalytic residue [active] 317936008685 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 317936008686 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 317936008687 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936008688 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 317936008689 DNA protecting protein DprA; Region: dprA; TIGR00732 317936008690 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936008691 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936008692 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936008693 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936008694 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936008695 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936008696 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 317936008697 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 317936008698 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 317936008699 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 317936008700 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 317936008701 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 317936008702 Caspase domain; Region: Peptidase_C14; pfam00656 317936008703 ribosomal protein L32; Validated; Region: rpl32; CHL00152 317936008704 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 317936008705 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 317936008706 Moco binding site; other site 317936008707 metal coordination site [ion binding]; other site 317936008708 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 317936008709 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 317936008710 NAD(P) binding site [chemical binding]; other site 317936008711 catalytic residues [active] 317936008712 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008714 active site 317936008715 phosphorylation site [posttranslational modification] 317936008716 intermolecular recognition site; other site 317936008717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008718 dimerization interface [polypeptide binding]; other site 317936008719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008720 dimer interface [polypeptide binding]; other site 317936008721 phosphorylation site [posttranslational modification] 317936008722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008723 ATP binding site [chemical binding]; other site 317936008724 Mg2+ binding site [ion binding]; other site 317936008725 G-X-G motif; other site 317936008726 amidophosphoribosyltransferase; Provisional; Region: PRK07349 317936008727 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 317936008728 active site 317936008729 tetramer interface [polypeptide binding]; other site 317936008730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936008731 active site 317936008732 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 317936008733 dimerization interface [polypeptide binding]; other site 317936008734 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 317936008735 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936008736 thioester formation/cholesterol transfer; other site 317936008737 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 317936008738 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 317936008739 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 317936008740 ATP binding site [chemical binding]; other site 317936008741 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 317936008742 dimerization interface [polypeptide binding]; other site 317936008743 ATP binding site [chemical binding]; other site 317936008744 Phycobilisome protein; Region: Phycobilisome; cl08227 317936008745 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 317936008746 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 317936008747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936008748 S-adenosylmethionine binding site [chemical binding]; other site 317936008749 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 317936008750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 317936008751 ATP binding site [chemical binding]; other site 317936008752 Mg2+ binding site [ion binding]; other site 317936008753 G-X-G motif; other site 317936008754 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 317936008755 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 317936008756 putative dimer interface [polypeptide binding]; other site 317936008757 putative anticodon binding site; other site 317936008758 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 317936008759 homodimer interface [polypeptide binding]; other site 317936008760 motif 1; other site 317936008761 motif 2; other site 317936008762 active site 317936008763 motif 3; other site 317936008764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936008765 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 317936008766 protein binding site [polypeptide binding]; other site 317936008767 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 317936008768 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 317936008769 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 317936008770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008771 dimerization interface [polypeptide binding]; other site 317936008772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008773 dimerization interface [polypeptide binding]; other site 317936008774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008775 dimerization interface [polypeptide binding]; other site 317936008776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008777 dimerization interface [polypeptide binding]; other site 317936008778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008779 dimerization interface [polypeptide binding]; other site 317936008780 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 317936008781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008782 dimerization interface [polypeptide binding]; other site 317936008783 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008784 dimerization interface [polypeptide binding]; other site 317936008785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008786 dimerization interface [polypeptide binding]; other site 317936008787 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 317936008788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008789 dimerization interface [polypeptide binding]; other site 317936008790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008791 dimerization interface [polypeptide binding]; other site 317936008792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008793 dimerization interface [polypeptide binding]; other site 317936008794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936008795 dimerization interface [polypeptide binding]; other site 317936008796 GAF domain; Region: GAF_2; pfam13185 317936008797 GAF domain; Region: GAF; pfam01590 317936008798 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008800 dimer interface [polypeptide binding]; other site 317936008801 phosphorylation site [posttranslational modification] 317936008802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008803 ATP binding site [chemical binding]; other site 317936008804 Mg2+ binding site [ion binding]; other site 317936008805 G-X-G motif; other site 317936008806 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008808 active site 317936008809 phosphorylation site [posttranslational modification] 317936008810 intermolecular recognition site; other site 317936008811 dimerization interface [polypeptide binding]; other site 317936008812 Response regulator receiver domain; Region: Response_reg; pfam00072 317936008813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008814 active site 317936008815 phosphorylation site [posttranslational modification] 317936008816 intermolecular recognition site; other site 317936008817 dimerization interface [polypeptide binding]; other site 317936008818 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936008819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936008820 active site 317936008821 phosphorylation site [posttranslational modification] 317936008822 intermolecular recognition site; other site 317936008823 dimerization interface [polypeptide binding]; other site 317936008824 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 317936008825 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 317936008826 UreF; Region: UreF; pfam01730 317936008827 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 317936008828 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 317936008829 dimer interface [polypeptide binding]; other site 317936008830 catalytic residues [active] 317936008831 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 317936008832 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 317936008833 putative catalytic cysteine [active] 317936008834 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 317936008835 active site 317936008836 dimerization interface [polypeptide binding]; other site 317936008837 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 317936008838 nucleoside/Zn binding site; other site 317936008839 dimer interface [polypeptide binding]; other site 317936008840 catalytic motif [active] 317936008841 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 317936008842 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 317936008843 substrate binding site [chemical binding]; other site 317936008844 dimer interface [polypeptide binding]; other site 317936008845 ATP binding site [chemical binding]; other site 317936008846 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936008847 putative active site [active] 317936008848 Calcium binding; Region: Calci_bind_CcbP; pfam11535 317936008849 maltose O-acetyltransferase; Provisional; Region: PRK10092 317936008850 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 317936008851 active site 317936008852 substrate binding site [chemical binding]; other site 317936008853 trimer interface [polypeptide binding]; other site 317936008854 CoA binding site [chemical binding]; other site 317936008855 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 317936008856 active site 317936008857 nucleophile elbow; other site 317936008858 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 317936008859 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936008860 putative active site [active] 317936008861 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936008862 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936008863 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936008864 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 317936008865 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 317936008866 metal binding site [ion binding]; metal-binding site 317936008867 dimer interface [polypeptide binding]; other site 317936008868 AAA domain; Region: AAA_26; pfam13500 317936008869 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 317936008870 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 317936008871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936008872 active site 317936008873 ATP binding site [chemical binding]; other site 317936008874 substrate binding site [chemical binding]; other site 317936008875 activation loop (A-loop); other site 317936008876 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812 317936008877 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 317936008878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936008879 active site 317936008880 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936008881 putative active site [active] 317936008882 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936008883 putative active site [active] 317936008884 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 317936008885 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 317936008886 Catalytic site [active] 317936008887 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 317936008888 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 317936008889 G1 box; other site 317936008890 putative GEF interaction site [polypeptide binding]; other site 317936008891 GTP/Mg2+ binding site [chemical binding]; other site 317936008892 Switch I region; other site 317936008893 G2 box; other site 317936008894 G3 box; other site 317936008895 Switch II region; other site 317936008896 G4 box; other site 317936008897 G5 box; other site 317936008898 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 317936008899 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 317936008900 Protein of unknown function (DUF497); Region: DUF497; pfam04365 317936008901 Domain of unknown function DUF29; Region: DUF29; pfam01724 317936008902 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008904 binding surface 317936008905 TPR motif; other site 317936008906 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008907 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008908 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008909 binding surface 317936008910 TPR motif; other site 317936008911 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936008914 binding surface 317936008915 TPR motif; other site 317936008916 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936008917 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936008918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936008919 active site 317936008920 GAF domain; Region: GAF; pfam01590 317936008921 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008922 GAF domain; Region: GAF; pfam01590 317936008923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936008924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936008925 dimer interface [polypeptide binding]; other site 317936008926 phosphorylation site [posttranslational modification] 317936008927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936008928 ATP binding site [chemical binding]; other site 317936008929 Mg2+ binding site [ion binding]; other site 317936008930 G-X-G motif; other site 317936008931 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866 317936008932 putative hydrophobic ligand binding site [chemical binding]; other site 317936008933 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 317936008934 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 317936008935 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 317936008936 TrkA-N domain; Region: TrkA_N; pfam02254 317936008937 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 317936008938 intrachain domain interface; other site 317936008939 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 317936008940 heme bH binding site [chemical binding]; other site 317936008941 heme bL binding site [chemical binding]; other site 317936008942 interchain domain interface [polypeptide binding]; other site 317936008943 Qo binding site; other site 317936008944 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 317936008945 PGAP1-like protein; Region: PGAP1; pfam07819 317936008946 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 317936008947 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 317936008948 cofactor binding site; other site 317936008949 DNA binding site [nucleotide binding] 317936008950 substrate interaction site [chemical binding]; other site 317936008951 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 317936008952 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 317936008953 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 317936008954 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 317936008955 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 317936008956 active site 317936008957 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 317936008958 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 317936008959 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 317936008960 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936008961 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 317936008962 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936008963 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 317936008964 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 317936008965 ATP binding site [chemical binding]; other site 317936008966 active site 317936008967 substrate binding site [chemical binding]; other site 317936008968 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008969 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008970 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936008971 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936008972 PAS domain; Region: PAS; smart00091 317936008973 putative active site [active] 317936008974 heme pocket [chemical binding]; other site 317936008975 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936008976 cyclase homology domain; Region: CHD; cd07302 317936008977 nucleotidyl binding site; other site 317936008978 metal binding site [ion binding]; metal-binding site 317936008979 dimer interface [polypeptide binding]; other site 317936008980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936008981 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 317936008982 UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255 317936008983 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936008984 NAD binding site [chemical binding]; other site 317936008985 substrate binding site [chemical binding]; other site 317936008986 active site 317936008987 Ycf46; Provisional; Region: ycf46; CHL00195 317936008988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936008989 Walker A motif; other site 317936008990 ATP binding site [chemical binding]; other site 317936008991 Walker B motif; other site 317936008992 arginine finger; other site 317936008993 Protein of unknown function (DUF1257); Region: DUF1257; pfam06868 317936008994 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936008995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936008996 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936008997 ABC-2 type transporter; Region: ABC2_membrane; cl17235 317936008998 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 317936008999 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 317936009000 AMIN domain; Region: AMIN; pfam11741 317936009001 Ethylene insensitive 3; Region: EIN3; cl04813 317936009002 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936009003 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 317936009004 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 317936009005 Ligand Binding Site [chemical binding]; other site 317936009006 Protein kinase domain; Region: Pkinase; pfam00069 317936009007 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936009008 active site 317936009009 ATP binding site [chemical binding]; other site 317936009010 substrate binding site [chemical binding]; other site 317936009011 activation loop (A-loop); other site 317936009012 AAA ATPase domain; Region: AAA_16; pfam13191 317936009013 Predicted ATPase [General function prediction only]; Region: COG3899 317936009014 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009015 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936009017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009018 ATP binding site [chemical binding]; other site 317936009019 Mg2+ binding site [ion binding]; other site 317936009020 G-X-G motif; other site 317936009021 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 317936009022 Clp protease ATP binding subunit; Region: clpC; CHL00095 317936009023 Clp amino terminal domain; Region: Clp_N; pfam02861 317936009024 Clp amino terminal domain; Region: Clp_N; pfam02861 317936009025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936009026 Walker A motif; other site 317936009027 ATP binding site [chemical binding]; other site 317936009028 Walker B motif; other site 317936009029 arginine finger; other site 317936009030 UvrB/uvrC motif; Region: UVR; pfam02151 317936009031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936009032 Walker A motif; other site 317936009033 ATP binding site [chemical binding]; other site 317936009034 Walker B motif; other site 317936009035 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 317936009036 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 317936009037 elongation factor G; Reviewed; Region: PRK12740 317936009038 G1 box; other site 317936009039 putative GEF interaction site [polypeptide binding]; other site 317936009040 GTP/Mg2+ binding site [chemical binding]; other site 317936009041 Switch I region; other site 317936009042 G2 box; other site 317936009043 G3 box; other site 317936009044 Switch II region; other site 317936009045 G4 box; other site 317936009046 G5 box; other site 317936009047 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 317936009048 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 317936009049 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 317936009050 TPR repeat; Region: TPR_11; pfam13414 317936009051 TPR repeat; Region: TPR_11; pfam13414 317936009052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009053 binding surface 317936009054 TPR motif; other site 317936009055 TPR repeat; Region: TPR_11; pfam13414 317936009056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009057 binding surface 317936009058 TPR repeat; Region: TPR_11; pfam13414 317936009059 TPR motif; other site 317936009060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009061 binding surface 317936009062 TPR repeat; Region: TPR_11; pfam13414 317936009063 TPR motif; other site 317936009064 Predicted membrane protein [Function unknown]; Region: COG3431 317936009065 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 317936009066 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 317936009067 muropeptide transporter; Reviewed; Region: ampG; PRK11902 317936009068 muropeptide transporter; Validated; Region: ampG; cl17669 317936009069 GxxExxY protein; Region: GxxExxY; TIGR04256 317936009070 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 317936009071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 317936009072 HIGH motif; other site 317936009073 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 317936009074 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 317936009075 active site 317936009076 KMSKS motif; other site 317936009077 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 317936009078 tRNA binding surface [nucleotide binding]; other site 317936009079 anticodon binding site; other site 317936009080 Domain of unknown function (DUF4308); Region: DUF4308; pfam14159 317936009081 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 317936009082 TPR repeat; Region: TPR_11; pfam13414 317936009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009084 TPR motif; other site 317936009085 TPR repeat; Region: TPR_11; pfam13414 317936009086 binding surface 317936009087 TPR repeat; Region: TPR_11; pfam13414 317936009088 phosphoribulokinase; Provisional; Region: PRK07429 317936009089 Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026 317936009090 active site 317936009091 ATP-grasp domain; Region: ATP-grasp_4; cl17255 317936009092 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936009093 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936009094 active site 317936009095 ATP binding site [chemical binding]; other site 317936009096 substrate binding site [chemical binding]; other site 317936009097 activation loop (A-loop); other site 317936009098 MFS/sugar transport protein; Region: MFS_2; pfam13347 317936009099 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936009100 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009101 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009102 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009103 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 317936009104 amidohydrolase; Region: amidohydrolases; TIGR01891 317936009105 metal binding site [ion binding]; metal-binding site 317936009106 dimer interface [polypeptide binding]; other site 317936009107 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 317936009108 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 317936009109 active site 317936009110 DNA binding site [nucleotide binding] 317936009111 Int/Topo IB signature motif; other site 317936009112 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 317936009113 AAA domain; Region: AAA_25; pfam13481 317936009114 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120 317936009115 Walker A motif; other site 317936009116 ATP binding site [chemical binding]; other site 317936009117 Walker B motif; other site 317936009118 Uncharacterized conserved protein [Function unknown]; Region: COG4544 317936009119 KGK domain; Region: KGK; pfam08872 317936009120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936009121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936009122 salt bridge; other site 317936009123 non-specific DNA binding site [nucleotide binding]; other site 317936009124 sequence-specific DNA binding site [nucleotide binding]; other site 317936009125 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 317936009126 Mg binding site [ion binding]; other site 317936009127 nucleotide binding site [chemical binding]; other site 317936009128 putative protofilament interface [polypeptide binding]; other site 317936009129 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 317936009130 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 317936009131 Phage-related protein [Function unknown]; Region: COG5412 317936009132 Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899 317936009133 hypothetical protein; Provisional; Region: PRK09256 317936009134 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 317936009135 16S rRNA methyltransferase B; Provisional; Region: PRK14901 317936009136 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 317936009137 putative RNA binding site [nucleotide binding]; other site 317936009138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936009139 S-adenosylmethionine binding site [chemical binding]; other site 317936009140 tellurium resistance terB-like protein; Region: terB_like; cd07177 317936009141 metal binding site [ion binding]; metal-binding site 317936009142 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 317936009143 Predicted transcriptional regulator [Transcription]; Region: COG3682 317936009144 2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886 317936009145 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 317936009146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 317936009147 AAA ATPase domain; Region: AAA_16; pfam13191 317936009148 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936009149 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936009150 structural tetrad; other site 317936009151 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936009152 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936009153 structural tetrad; other site 317936009154 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936009155 structural tetrad; other site 317936009156 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 317936009157 Double zinc ribbon; Region: DZR; pfam12773 317936009158 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 317936009159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936009160 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936009161 phosphopeptide binding site; other site 317936009162 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 317936009163 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 317936009164 putative active site [active] 317936009165 Tetratricopeptide repeat; Region: TPR_10; pfam13374 317936009166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009168 binding surface 317936009169 TPR motif; other site 317936009170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009171 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009173 binding surface 317936009174 TPR motif; other site 317936009175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009176 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936009178 binding surface 317936009179 TPR motif; other site 317936009180 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009181 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009182 CHAT domain; Region: CHAT; pfam12770 317936009183 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 317936009184 ribonuclease PH; Reviewed; Region: rph; PRK00173 317936009185 Ribonuclease PH; Region: RNase_PH_bact; cd11362 317936009186 hexamer interface [polypeptide binding]; other site 317936009187 active site 317936009188 adenylate kinase; Provisional; Region: adk; PRK02496 317936009189 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 317936009190 AMP-binding site [chemical binding]; other site 317936009191 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 317936009192 cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414 317936009193 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 317936009194 deoxycytidine triphosphate deaminase; Reviewed; Region: dcd; PRK00416 317936009195 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936009196 protein-splicing catalytic site; other site 317936009197 thioester formation/cholesterol transfer; other site 317936009198 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 317936009199 trimer interface [polypeptide binding]; other site 317936009200 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 317936009201 active site 317936009202 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 317936009203 trimer interface [polypeptide binding]; other site 317936009204 active site 317936009205 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 317936009206 trimer interface [polypeptide binding]; other site 317936009207 active site 317936009208 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009209 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936009210 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936009211 DNA binding residues [nucleotide binding] 317936009212 dimerization interface [polypeptide binding]; other site 317936009213 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 317936009214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936009215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009216 active site 317936009217 phosphorylation site [posttranslational modification] 317936009218 intermolecular recognition site; other site 317936009219 dimerization interface [polypeptide binding]; other site 317936009220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936009221 DNA binding residues [nucleotide binding] 317936009222 dimerization interface [polypeptide binding]; other site 317936009223 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 317936009224 oligomerisation interface [polypeptide binding]; other site 317936009225 mobile loop; other site 317936009226 roof hairpin; other site 317936009227 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 317936009228 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 317936009229 ring oligomerisation interface [polypeptide binding]; other site 317936009230 ATP/Mg binding site [chemical binding]; other site 317936009231 stacking interactions; other site 317936009232 hinge regions; other site 317936009233 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936009234 oligomeric interface; other site 317936009235 putative active site [active] 317936009236 homodimer interface [polypeptide binding]; other site 317936009237 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 317936009238 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009239 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009240 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009241 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936009243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936009244 metal binding site [ion binding]; metal-binding site 317936009245 active site 317936009246 I-site; other site 317936009247 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 317936009248 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 317936009249 putative active site [active] 317936009250 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 317936009251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936009252 FeS/SAM binding site; other site 317936009253 HemN C-terminal domain; Region: HemN_C; pfam06969 317936009254 Uncharacterized conserved protein [Function unknown]; Region: COG1543 317936009255 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 317936009256 active site 317936009257 substrate binding site [chemical binding]; other site 317936009258 catalytic site [active] 317936009259 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 317936009260 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 317936009261 NADH(P)-binding; Region: NAD_binding_10; pfam13460 317936009262 putative NAD(P) binding site [chemical binding]; other site 317936009263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936009264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936009265 dimerization interface [polypeptide binding]; other site 317936009266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936009267 dimer interface [polypeptide binding]; other site 317936009268 phosphorylation site [posttranslational modification] 317936009269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009270 ATP binding site [chemical binding]; other site 317936009271 Mg2+ binding site [ion binding]; other site 317936009272 G-X-G motif; other site 317936009273 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936009274 HSP70 interaction site [polypeptide binding]; other site 317936009275 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009276 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936009277 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009278 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009279 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 317936009280 3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398 317936009281 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 317936009282 Uncharacterized conserved protein [Function unknown]; Region: COG3349 317936009283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936009284 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 317936009285 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 317936009286 active site 317936009287 zinc binding site [ion binding]; other site 317936009288 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 317936009289 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 317936009290 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009291 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009292 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009293 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009294 HEAT repeats; Region: HEAT_2; pfam13646 317936009295 HEAT repeats; Region: HEAT_2; pfam13646 317936009296 HEAT repeats; Region: HEAT_2; pfam13646 317936009297 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 317936009298 HEAT repeats; Region: HEAT_2; pfam13646 317936009299 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 317936009300 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009301 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 317936009302 phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338 317936009303 Phycobilisome protein; Region: Phycobilisome; cl08227 317936009304 HEAT repeats; Region: HEAT_2; pfam13646 317936009305 HEAT repeats; Region: HEAT_2; pfam13646 317936009306 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 317936009307 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 317936009308 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936009309 CpcD/allophycocyanin linker domain; Region: CpcD; smart01094 317936009310 Phycobilisome protein; Region: Phycobilisome; cl08227 317936009311 Phycobilisome protein; Region: Phycobilisome; cl08227 317936009312 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 317936009313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936009314 RNA binding surface [nucleotide binding]; other site 317936009315 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 317936009316 active site 317936009317 Transposase; Region: DEDD_Tnp_IS110; pfam01548 317936009318 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 317936009319 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 317936009320 active site 317936009321 catalytic residues [active] 317936009322 DNA binding site [nucleotide binding] 317936009323 Int/Topo IB signature motif; other site 317936009324 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 317936009325 Response regulator receiver domain; Region: Response_reg; pfam00072 317936009326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009327 active site 317936009328 phosphorylation site [posttranslational modification] 317936009329 intermolecular recognition site; other site 317936009330 dimerization interface [polypeptide binding]; other site 317936009331 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 317936009332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 317936009333 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 317936009334 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936009335 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936009336 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936009337 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 317936009338 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 317936009339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936009340 dimer interface [polypeptide binding]; other site 317936009341 conserved gate region; other site 317936009342 putative PBP binding loops; other site 317936009343 ABC-ATPase subunit interface; other site 317936009344 Response regulator receiver domain; Region: Response_reg; pfam00072 317936009345 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009346 active site 317936009347 phosphorylation site [posttranslational modification] 317936009348 intermolecular recognition site; other site 317936009349 dimerization interface [polypeptide binding]; other site 317936009350 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936009351 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009352 putative active site [active] 317936009353 heme pocket [chemical binding]; other site 317936009354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936009355 dimer interface [polypeptide binding]; other site 317936009356 phosphorylation site [posttranslational modification] 317936009357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009358 ATP binding site [chemical binding]; other site 317936009359 Mg2+ binding site [ion binding]; other site 317936009360 G-X-G motif; other site 317936009361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936009362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009363 active site 317936009364 phosphorylation site [posttranslational modification] 317936009365 intermolecular recognition site; other site 317936009366 dimerization interface [polypeptide binding]; other site 317936009367 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 317936009368 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 317936009369 substrate binding site [chemical binding]; other site 317936009370 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 317936009371 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 317936009372 substrate binding site [chemical binding]; other site 317936009373 ligand binding site [chemical binding]; other site 317936009374 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 317936009375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 317936009376 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936009377 anti sigma factor interaction site; other site 317936009378 regulatory phosphorylation site [posttranslational modification]; other site 317936009379 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 317936009380 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234 317936009381 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 317936009382 active site 317936009383 catalytic site [active] 317936009384 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009385 GAF domain; Region: GAF; pfam01590 317936009386 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 317936009387 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 317936009388 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936009389 anti sigma factor interaction site; other site 317936009390 regulatory phosphorylation site [posttranslational modification]; other site 317936009391 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 317936009392 dimerization interface [polypeptide binding]; other site 317936009393 putative active cleft [active] 317936009394 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 317936009395 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 317936009396 conserved cys residue [active] 317936009397 PQQ-like domain; Region: PQQ_2; pfam13360 317936009398 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 317936009399 structural tetrad; other site 317936009400 tropinone reductase; Provisional; Region: PRK09242 317936009401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936009402 NAD(P) binding site [chemical binding]; other site 317936009403 active site 317936009404 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 317936009405 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 317936009406 substrate binding site [chemical binding]; other site 317936009407 oxyanion hole (OAH) forming residues; other site 317936009408 trimer interface [polypeptide binding]; other site 317936009409 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 317936009410 Uncharacterized conserved protein [Function unknown]; Region: COG1359 317936009411 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 317936009412 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 317936009413 nudix motif; other site 317936009414 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936009415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936009416 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 317936009417 Fatty acid desaturase; Region: FA_desaturase; pfam00487 317936009418 Di-iron ligands [ion binding]; other site 317936009419 Protein of unknown function (DUF2393); Region: DUF2393; pfam09624 317936009420 TIGR02588 family protein; Region: TIGR02588 317936009421 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936009422 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 317936009423 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 317936009424 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 317936009425 DNA binding site [nucleotide binding] 317936009426 active site 317936009427 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 317936009428 active site 317936009429 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 317936009430 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 317936009431 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 317936009432 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 317936009433 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 317936009434 Psb28 protein; Region: Psb28; pfam03912 317936009435 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 317936009436 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936009437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936009438 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936009439 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 317936009440 DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191 317936009441 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009443 active site 317936009444 phosphorylation site [posttranslational modification] 317936009445 intermolecular recognition site; other site 317936009446 dimerization interface [polypeptide binding]; other site 317936009447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009448 putative active site [active] 317936009449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936009450 heme pocket [chemical binding]; other site 317936009451 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936009452 dimer interface [polypeptide binding]; other site 317936009453 phosphorylation site [posttranslational modification] 317936009454 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009455 ATP binding site [chemical binding]; other site 317936009456 Mg2+ binding site [ion binding]; other site 317936009457 G-X-G motif; other site 317936009458 hypothetical protein; Provisional; Region: PRK13560 317936009459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009460 putative active site [active] 317936009461 heme pocket [chemical binding]; other site 317936009462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009463 putative active site [active] 317936009464 heme pocket [chemical binding]; other site 317936009465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009466 putative active site [active] 317936009467 heme pocket [chemical binding]; other site 317936009468 Histidine kinase; Region: HisKA_2; pfam07568 317936009469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009470 ATP binding site [chemical binding]; other site 317936009471 Mg2+ binding site [ion binding]; other site 317936009472 G-X-G motif; other site 317936009473 threonine synthase; Reviewed; Region: PRK06721 317936009474 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 317936009475 homodimer interface [polypeptide binding]; other site 317936009476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936009477 catalytic residue [active] 317936009478 S-layer homology domain; Region: SLH; pfam00395 317936009479 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936009480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936009481 dimer interface [polypeptide binding]; other site 317936009482 conserved gate region; other site 317936009483 putative PBP binding loops; other site 317936009484 ABC-ATPase subunit interface; other site 317936009485 sulfate transport protein; Provisional; Region: cysT; CHL00187 317936009486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936009487 dimer interface [polypeptide binding]; other site 317936009488 conserved gate region; other site 317936009489 putative PBP binding loops; other site 317936009490 ABC-ATPase subunit interface; other site 317936009491 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 317936009492 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 317936009493 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 317936009494 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 317936009495 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 317936009496 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936009497 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936009498 short chain dehydrogenase; Provisional; Region: PRK06500 317936009499 classical (c) SDRs; Region: SDR_c; cd05233 317936009500 NAD(P) binding site [chemical binding]; other site 317936009501 active site 317936009502 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 317936009503 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 317936009504 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 317936009505 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 317936009506 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936009507 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 317936009508 N-terminal domain interface [polypeptide binding]; other site 317936009509 dimer interface [polypeptide binding]; other site 317936009510 substrate binding pocket (H-site) [chemical binding]; other site 317936009511 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 317936009512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936009513 active site 317936009514 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 317936009515 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 317936009516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936009517 Ligand Binding Site [chemical binding]; other site 317936009518 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936009519 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936009520 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936009521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936009522 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936009523 Uncharacterized conserved protein [Function unknown]; Region: COG3391 317936009524 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 317936009525 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 317936009526 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936009527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009528 active site 317936009529 phosphorylation site [posttranslational modification] 317936009530 intermolecular recognition site; other site 317936009531 dimerization interface [polypeptide binding]; other site 317936009532 Response regulator receiver domain; Region: Response_reg; pfam00072 317936009533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009534 active site 317936009535 phosphorylation site [posttranslational modification] 317936009536 intermolecular recognition site; other site 317936009537 dimerization interface [polypeptide binding]; other site 317936009538 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 317936009539 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009540 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009541 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009542 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009543 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009544 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009545 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009546 GAF domain; Region: GAF; pfam01590 317936009547 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 317936009548 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 317936009549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 317936009550 dimer interface [polypeptide binding]; other site 317936009551 putative CheW interface [polypeptide binding]; other site 317936009552 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 317936009553 putative binding surface; other site 317936009554 active site 317936009555 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 317936009556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009557 ATP binding site [chemical binding]; other site 317936009558 Mg2+ binding site [ion binding]; other site 317936009559 G-X-G motif; other site 317936009560 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 317936009561 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936009562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009563 active site 317936009564 phosphorylation site [posttranslational modification] 317936009565 intermolecular recognition site; other site 317936009566 dimerization interface [polypeptide binding]; other site 317936009567 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 317936009568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936009569 dimer interface [polypeptide binding]; other site 317936009570 conserved gate region; other site 317936009571 putative PBP binding loops; other site 317936009572 ABC-ATPase subunit interface; other site 317936009573 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 317936009574 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 317936009575 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 317936009576 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 317936009577 Walker A/P-loop; other site 317936009578 ATP binding site [chemical binding]; other site 317936009579 Q-loop/lid; other site 317936009580 ABC transporter signature motif; other site 317936009581 Walker B; other site 317936009582 D-loop; other site 317936009583 H-loop/switch region; other site 317936009584 TOBE domain; Region: TOBE_2; pfam08402 317936009585 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 317936009586 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 317936009587 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 317936009588 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 317936009589 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 317936009590 S-layer homology domain; Region: SLH; pfam00395 317936009591 S-layer homology domain; Region: SLH; pfam00395 317936009592 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 317936009593 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 317936009594 NAD binding site [chemical binding]; other site 317936009595 ATP-grasp domain; Region: ATP-grasp; pfam02222 317936009596 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936009597 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009599 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936009600 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936009601 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009602 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 317936009603 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 317936009604 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 317936009605 active site 317936009606 metal binding site [ion binding]; metal-binding site 317936009607 hexamer interface [polypeptide binding]; other site 317936009608 Putative phosphatase (DUF442); Region: DUF442; cl17385 317936009609 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936009610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009611 active site 317936009612 phosphorylation site [posttranslational modification] 317936009613 intermolecular recognition site; other site 317936009614 dimerization interface [polypeptide binding]; other site 317936009615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936009616 DNA binding site [nucleotide binding] 317936009617 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649 317936009618 ATP-NAD kinase; Region: NAD_kinase; pfam01513 317936009619 Ycf39; Provisional; Region: ycf39; CHL00194 317936009620 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 317936009621 NAD(P) binding site [chemical binding]; other site 317936009622 putative active site [active] 317936009623 cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876 317936009624 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746 317936009625 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 317936009626 membrane protein; Provisional; Region: PRK14419 317936009627 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 317936009628 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936009629 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 317936009630 YcxB-like protein; Region: YcxB; pfam14317 317936009631 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936009632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009633 active site 317936009634 phosphorylation site [posttranslational modification] 317936009635 intermolecular recognition site; other site 317936009636 dimerization interface [polypeptide binding]; other site 317936009637 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009638 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009639 PAS domain S-box; Region: sensory_box; TIGR00229 317936009640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009641 putative active site [active] 317936009642 heme pocket [chemical binding]; other site 317936009643 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009644 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009646 PAS fold; Region: PAS_3; pfam08447 317936009647 putative active site [active] 317936009648 heme pocket [chemical binding]; other site 317936009649 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936009650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936009651 putative active site [active] 317936009652 heme pocket [chemical binding]; other site 317936009653 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936009654 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936009655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936009656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936009657 dimer interface [polypeptide binding]; other site 317936009658 phosphorylation site [posttranslational modification] 317936009659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936009660 ATP binding site [chemical binding]; other site 317936009661 Mg2+ binding site [ion binding]; other site 317936009662 G-X-G motif; other site 317936009663 Response regulator receiver domain; Region: Response_reg; pfam00072 317936009664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936009665 active site 317936009666 phosphorylation site [posttranslational modification] 317936009667 intermolecular recognition site; other site 317936009668 dimerization interface [polypeptide binding]; other site 317936009669 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 317936009670 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 317936009671 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 317936009672 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 317936009673 putative homodimer interface [polypeptide binding]; other site 317936009674 putative active site pocket [active] 317936009675 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 317936009676 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 317936009677 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 317936009678 trimer interface [polypeptide binding]; other site 317936009679 active site 317936009680 substrate binding site [chemical binding]; other site 317936009681 CoA binding site [chemical binding]; other site 317936009682 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 317936009683 homodimer interface [polypeptide binding]; other site 317936009684 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 317936009685 active site pocket [active] 317936009686 photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655 317936009687 OstA-like protein; Region: OstA; cl00844 317936009688 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 317936009689 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 317936009690 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 317936009691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936009692 active site 317936009693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009694 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 317936009695 putative ADP-binding pocket [chemical binding]; other site 317936009696 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 317936009697 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 317936009698 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 317936009699 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 317936009700 metal ion-dependent adhesion site (MIDAS); other site 317936009701 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 317936009702 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 317936009703 dimer interface [polypeptide binding]; other site 317936009704 decamer (pentamer of dimers) interface [polypeptide binding]; other site 317936009705 catalytic triad [active] 317936009706 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936009707 putative active site [active] 317936009708 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 317936009709 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 317936009710 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 317936009711 Borrelia burgdorferi protein of unknown function (DUF759); Region: DUF759; pfam05537 317936009712 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 317936009713 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 317936009714 vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461 317936009715 metal ion-dependent adhesion site (MIDAS); other site 317936009716 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 317936009717 Dynamin family; Region: Dynamin_N; pfam00350 317936009718 G1 box; other site 317936009719 GTP/Mg2+ binding site [chemical binding]; other site 317936009720 G2 box; other site 317936009721 Switch I region; other site 317936009722 G3 box; other site 317936009723 Switch II region; other site 317936009724 G4 box; other site 317936009725 G5 box; other site 317936009726 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936009727 HSP70 interaction site [polypeptide binding]; other site 317936009728 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 317936009729 Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699 317936009730 Switch II region; other site 317936009731 G4 box; other site 317936009732 G5 box; other site 317936009733 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 317936009734 dimer interface [polypeptide binding]; other site 317936009735 [2Fe-2S] cluster binding site [ion binding]; other site 317936009736 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 317936009737 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 317936009738 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 317936009739 putative active site [active] 317936009740 putative substrate binding site [chemical binding]; other site 317936009741 putative cosubstrate binding site; other site 317936009742 catalytic site [active] 317936009743 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 317936009744 Protein of unknown function (DUF3487); Region: DUF3487; cl13432 317936009745 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 317936009746 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 317936009747 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 317936009748 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936009749 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 317936009750 Walker A/P-loop; other site 317936009751 ATP binding site [chemical binding]; other site 317936009752 Q-loop/lid; other site 317936009753 ABC transporter signature motif; other site 317936009754 Walker B; other site 317936009755 D-loop; other site 317936009756 H-loop/switch region; other site 317936009757 S-layer homology domain; Region: SLH; pfam00395 317936009758 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936009759 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 317936009760 MarR family; Region: MarR; pfam01047 317936009761 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 317936009762 dimer interface [polypeptide binding]; other site 317936009763 [2Fe-2S] cluster binding site [ion binding]; other site 317936009764 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 317936009765 four helix bundle protein; Region: TIGR02436 317936009766 NifT/FixU protein; Region: NifT; pfam06988 317936009767 NifZ domain; Region: NifZ; pfam04319 317936009768 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 317936009769 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 317936009770 active site 317936009771 catalytic residues [active] 317936009772 metal binding site [ion binding]; metal-binding site 317936009773 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 317936009774 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 317936009775 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 317936009776 trimer interface [polypeptide binding]; other site 317936009777 active site 317936009778 substrate binding site [chemical binding]; other site 317936009779 CoA binding site [chemical binding]; other site 317936009780 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 317936009781 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936009782 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936009783 active site 317936009784 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 317936009785 YcfA-like protein; Region: YcfA; pfam07927 317936009786 NACHT domain; Region: NACHT; pfam05729 317936009787 HEAT repeats; Region: HEAT_2; pfam13646 317936009788 HEAT repeats; Region: HEAT_2; pfam13646 317936009789 HEAT repeats; Region: HEAT_2; pfam13646 317936009790 HEAT repeats; Region: HEAT_2; pfam13646 317936009791 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 317936009792 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 317936009793 NADP-binding site; other site 317936009794 homotetramer interface [polypeptide binding]; other site 317936009795 substrate binding site [chemical binding]; other site 317936009796 homodimer interface [polypeptide binding]; other site 317936009797 active site 317936009798 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 317936009799 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936009800 FeS/SAM binding site; other site 317936009801 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 317936009802 4Fe-4S binding domain; Region: Fer4; cl02805 317936009803 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 317936009804 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936009805 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 317936009806 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936009807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009808 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936009809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936009810 S-adenosylmethionine binding site [chemical binding]; other site 317936009811 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 317936009812 trimer interface [polypeptide binding]; other site 317936009813 active site 317936009814 substrate binding site [chemical binding]; other site 317936009815 CoA binding site [chemical binding]; other site 317936009816 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 317936009817 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009818 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 317936009819 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 317936009820 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 317936009821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936009822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936009823 DNA binding residues [nucleotide binding] 317936009824 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936009825 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936009826 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936009827 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936009828 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 317936009829 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 317936009830 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 317936009831 PYR/PP interface [polypeptide binding]; other site 317936009832 dimer interface [polypeptide binding]; other site 317936009833 TPP binding site [chemical binding]; other site 317936009834 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 317936009835 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 317936009836 TPP-binding site [chemical binding]; other site 317936009837 dimer interface [polypeptide binding]; other site 317936009838 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 317936009839 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 317936009840 active site 317936009841 Jacalin-like lectin domain; Region: Jacalin_like; cl03205 317936009842 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 317936009843 active site 317936009844 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 317936009845 dimer interface [polypeptide binding]; other site 317936009846 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936009847 Ligand Binding Site [chemical binding]; other site 317936009848 Molecular Tunnel; other site 317936009849 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 317936009850 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 317936009851 Chain length determinant protein; Region: Wzz; cl15801 317936009852 Chain length determinant protein; Region: Wzz; cl15801 317936009853 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 317936009854 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936009855 P-loop; other site 317936009856 Magnesium ion binding site [ion binding]; other site 317936009857 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 317936009858 metal-binding site 317936009859 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936009860 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936009861 S-adenosylmethionine binding site [chemical binding]; other site 317936009862 Uncharacterized conserved protein [Function unknown]; Region: COG3379 317936009863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009864 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 317936009865 putative ADP-binding pocket [chemical binding]; other site 317936009866 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936009867 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936009868 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 317936009869 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 317936009870 catalytic residues [active] 317936009871 catalytic nucleophile [active] 317936009872 Presynaptic Site I dimer interface [polypeptide binding]; other site 317936009873 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 317936009874 Synaptic Flat tetramer interface [polypeptide binding]; other site 317936009875 Synaptic Site I dimer interface [polypeptide binding]; other site 317936009876 DNA binding site [nucleotide binding] 317936009877 Recombinase; Region: Recombinase; pfam07508 317936009878 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 317936009879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 317936009880 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 317936009881 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 317936009882 catalytic residues [active] 317936009883 catalytic nucleophile [active] 317936009884 Presynaptic Site I dimer interface [polypeptide binding]; other site 317936009885 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 317936009886 Synaptic Flat tetramer interface [polypeptide binding]; other site 317936009887 Synaptic Site I dimer interface [polypeptide binding]; other site 317936009888 DNA binding site [nucleotide binding] 317936009889 Recombinase; Region: Recombinase; pfam07508 317936009890 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 317936009891 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 317936009892 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 317936009893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936009894 catalytic residue [active] 317936009895 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 317936009896 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 317936009897 trimerization site [polypeptide binding]; other site 317936009898 active site 317936009899 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 317936009900 NifU-like domain; Region: NifU; pfam01106 317936009901 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 317936009902 apolar tunnel; other site 317936009903 heme binding site [chemical binding]; other site 317936009904 dimerization interface [polypeptide binding]; other site 317936009905 nitrogenase reductase; Reviewed; Region: PRK13236 317936009906 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 317936009907 Nucleotide-binding sites [chemical binding]; other site 317936009908 Walker A motif; other site 317936009909 Switch I region of nucleotide binding site; other site 317936009910 Fe4S4 binding sites [ion binding]; other site 317936009911 Switch II region of nucleotide binding site; other site 317936009912 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 317936009913 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 317936009914 MoFe protein alpha/beta subunit interactions; other site 317936009915 Alpha subunit P cluster binding residues; other site 317936009916 FeMoco binding residues [chemical binding]; other site 317936009917 MoFe protein alpha subunit/Fe protein contacts; other site 317936009918 MoFe protein dimer/ dimer interactions; other site 317936009919 DNA methylase; Region: N6_N4_Mtase; cl17433 317936009920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 317936009921 Methyltransferase domain; Region: Methyltransf_26; pfam13659 317936009922 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 317936009923 active site 317936009924 catalytic residues [active] 317936009925 DNA binding site [nucleotide binding] 317936009926 Int/Topo IB signature motif; other site 317936009927 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 317936009928 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 317936009929 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 317936009930 MoFe protein beta/alpha subunit interactions; other site 317936009931 Beta subunit P cluster binding residues; other site 317936009932 MoFe protein beta subunit/Fe protein contacts; other site 317936009933 MoFe protein dimer/ dimer interactions; other site 317936009934 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 317936009935 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 317936009936 Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN. NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968 317936009937 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 317936009938 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 317936009939 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 317936009940 Protein of unknown function, DUF269; Region: DUF269; pfam03270 317936009941 Rop-like; Region: Rop-like; pfam05082 317936009942 nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102 317936009943 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 317936009944 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 317936009945 ATP binding site [chemical binding]; other site 317936009946 substrate interface [chemical binding]; other site 317936009947 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 317936009948 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936009949 catalytic loop [active] 317936009950 iron binding site [ion binding]; other site 317936009951 FeoA domain; Region: FeoA; pfam04023 317936009952 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 317936009953 FOG: CBS domain [General function prediction only]; Region: COG0517 317936009954 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630 317936009955 CP12 domain; Region: CP12; smart01093 317936009956 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 317936009957 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936009958 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936009959 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 317936009960 NADPH bind site [chemical binding]; other site 317936009961 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 317936009962 putative FMN binding site [chemical binding]; other site 317936009963 NADPH bind site [chemical binding]; other site 317936009964 This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063 317936009965 nickel binding site [ion binding]; other site 317936009966 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 317936009967 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 317936009968 colanic acid exporter; Provisional; Region: PRK10459 317936009969 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 317936009970 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 317936009971 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 317936009972 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 317936009973 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 317936009974 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936009975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936009976 active site 317936009977 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009978 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936009979 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 317936009980 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936009981 active site 317936009982 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009983 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 317936009984 putative ADP-binding pocket [chemical binding]; other site 317936009985 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936009986 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009988 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936009989 O-Antigen ligase; Region: Wzy_C; pfam04932 317936009990 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936009991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009992 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936009993 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936009994 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 317936009995 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 317936009996 putative active site [active] 317936009997 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 317936009998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936009999 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936010001 CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383 317936010002 Phycobilisome protein; Region: Phycobilisome; cl08227 317936010003 Phycobilisome protein; Region: Phycobilisome; cl08227 317936010004 phycobillisome linker protein; Region: apcE; CHL00091 317936010005 Phycobilisome protein; Region: Phycobilisome; cl08227 317936010006 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936010007 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936010008 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936010009 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 317936010010 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936010011 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010012 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936010013 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010014 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936010015 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010016 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010017 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 317936010018 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 317936010019 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936010020 M28 Zn-Peptidases; Region: M28_like_1; cd05640 317936010021 Peptidase family M28; Region: Peptidase_M28; pfam04389 317936010022 metal binding site [ion binding]; metal-binding site 317936010023 Uncharacterized conserved protein [Function unknown]; Region: COG2836 317936010024 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 317936010025 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 317936010026 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 317936010027 NAD binding site [chemical binding]; other site 317936010028 homodimer interface [polypeptide binding]; other site 317936010029 active site 317936010030 substrate binding site [chemical binding]; other site 317936010031 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936010032 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936010033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936010034 Walker A/P-loop; other site 317936010035 ATP binding site [chemical binding]; other site 317936010036 Q-loop/lid; other site 317936010037 ABC transporter signature motif; other site 317936010038 Walker B; other site 317936010039 D-loop; other site 317936010040 H-loop/switch region; other site 317936010041 Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370 317936010042 Bacterial sugar transferase; Region: Bac_transf; pfam02397 317936010043 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 317936010044 Response regulator receiver domain; Region: Response_reg; pfam00072 317936010045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010046 active site 317936010047 phosphorylation site [posttranslational modification] 317936010048 intermolecular recognition site; other site 317936010049 dimerization interface [polypeptide binding]; other site 317936010050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010051 ATP binding site [chemical binding]; other site 317936010052 Mg2+ binding site [ion binding]; other site 317936010053 G-X-G motif; other site 317936010054 Response regulator receiver domain; Region: Response_reg; pfam00072 317936010055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010056 active site 317936010057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010058 phosphorylation site [posttranslational modification] 317936010059 intermolecular recognition site; other site 317936010060 dimerization interface [polypeptide binding]; other site 317936010061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010062 dimer interface [polypeptide binding]; other site 317936010063 phosphorylation site [posttranslational modification] 317936010064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010065 ATP binding site [chemical binding]; other site 317936010066 Mg2+ binding site [ion binding]; other site 317936010067 G-X-G motif; other site 317936010068 Cache domain; Region: Cache_1; pfam02743 317936010069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010070 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936010071 dimerization interface [polypeptide binding]; other site 317936010072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010073 dimer interface [polypeptide binding]; other site 317936010074 phosphorylation site [posttranslational modification] 317936010075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010076 ATP binding site [chemical binding]; other site 317936010077 Mg2+ binding site [ion binding]; other site 317936010078 G-X-G motif; other site 317936010079 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936010080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010081 active site 317936010082 phosphorylation site [posttranslational modification] 317936010083 intermolecular recognition site; other site 317936010084 dimerization interface [polypeptide binding]; other site 317936010085 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 317936010086 G1 box; other site 317936010087 GTP/Mg2+ binding site [chemical binding]; other site 317936010088 Switch I region; other site 317936010089 G3 box; other site 317936010090 Switch II region; other site 317936010091 G4 box; other site 317936010092 Domain of unknown function (DUF697); Region: DUF697; pfam05128 317936010093 L-asparaginase II; Region: Asparaginase_II; cl01842 317936010094 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 317936010095 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 317936010096 putative glycosyl transferase; Provisional; Region: PRK10307 317936010097 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 317936010098 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 317936010099 active site clefts [active] 317936010100 zinc binding site [ion binding]; other site 317936010101 dimer interface [polypeptide binding]; other site 317936010102 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 317936010103 transmembrane helices; other site 317936010104 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 317936010105 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 317936010106 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 317936010107 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 317936010108 DNA-binding site [nucleotide binding]; DNA binding site 317936010109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936010110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936010111 homodimer interface [polypeptide binding]; other site 317936010112 catalytic residue [active] 317936010113 Protein of unknown function (DUF938); Region: DUF938; pfam06080 317936010114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 317936010115 Protein kinase domain; Region: Pkinase; pfam00069 317936010116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010117 active site 317936010118 ATP binding site [chemical binding]; other site 317936010119 substrate binding site [chemical binding]; other site 317936010120 activation loop (A-loop); other site 317936010121 AAA ATPase domain; Region: AAA_16; pfam13191 317936010122 Predicted ATPase [General function prediction only]; Region: COG3899 317936010123 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010124 GAF domain; Region: GAF; pfam01590 317936010125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010127 dimer interface [polypeptide binding]; other site 317936010128 phosphorylation site [posttranslational modification] 317936010129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010130 ATP binding site [chemical binding]; other site 317936010131 Mg2+ binding site [ion binding]; other site 317936010132 G-X-G motif; other site 317936010133 Protein kinase domain; Region: Pkinase; pfam00069 317936010134 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010135 active site 317936010136 ATP binding site [chemical binding]; other site 317936010137 substrate binding site [chemical binding]; other site 317936010138 substrate binding site [chemical binding]; other site 317936010139 activation loop (A-loop); other site 317936010140 activation loop (A-loop); other site 317936010141 AAA ATPase domain; Region: AAA_16; pfam13191 317936010142 Predicted ATPase [General function prediction only]; Region: COG3899 317936010143 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010144 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936010145 PAS domain S-box; Region: sensory_box; TIGR00229 317936010146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936010147 putative active site [active] 317936010148 heme pocket [chemical binding]; other site 317936010149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010151 ATP binding site [chemical binding]; other site 317936010152 Mg2+ binding site [ion binding]; other site 317936010153 G-X-G motif; other site 317936010154 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 317936010155 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 317936010156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936010158 dimerization interface [polypeptide binding]; other site 317936010159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010160 dimer interface [polypeptide binding]; other site 317936010161 phosphorylation site [posttranslational modification] 317936010162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010163 ATP binding site [chemical binding]; other site 317936010164 Mg2+ binding site [ion binding]; other site 317936010165 G-X-G motif; other site 317936010166 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936010167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010168 active site 317936010169 phosphorylation site [posttranslational modification] 317936010170 intermolecular recognition site; other site 317936010171 dimerization interface [polypeptide binding]; other site 317936010172 Response regulator receiver domain; Region: Response_reg; pfam00072 317936010173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010174 active site 317936010175 phosphorylation site [posttranslational modification] 317936010176 intermolecular recognition site; other site 317936010177 dimerization interface [polypeptide binding]; other site 317936010178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010180 ATP binding site [chemical binding]; other site 317936010181 Mg2+ binding site [ion binding]; other site 317936010182 G-X-G motif; other site 317936010183 Protein kinase domain; Region: Pkinase; pfam00069 317936010184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010185 active site 317936010186 ATP binding site [chemical binding]; other site 317936010187 substrate binding site [chemical binding]; other site 317936010188 activation loop (A-loop); other site 317936010189 AAA ATPase domain; Region: AAA_16; pfam13191 317936010190 Predicted ATPase [General function prediction only]; Region: COG3899 317936010191 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010192 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936010193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010195 ATP binding site [chemical binding]; other site 317936010196 Mg2+ binding site [ion binding]; other site 317936010197 G-X-G motif; other site 317936010198 Protein kinase domain; Region: Pkinase; pfam00069 317936010199 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010200 active site 317936010201 ATP binding site [chemical binding]; other site 317936010202 substrate binding site [chemical binding]; other site 317936010203 substrate binding site [chemical binding]; other site 317936010204 activation loop (A-loop); other site 317936010205 activation loop (A-loop); other site 317936010206 AAA ATPase domain; Region: AAA_16; pfam13191 317936010207 Predicted ATPase [General function prediction only]; Region: COG3899 317936010208 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010209 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936010210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010212 ATP binding site [chemical binding]; other site 317936010213 Mg2+ binding site [ion binding]; other site 317936010214 G-X-G motif; other site 317936010215 chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041 317936010216 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936010217 flavodoxin FldA; Validated; Region: PRK09267 317936010218 Penicillin amidase; Region: Penicil_amidase; pfam01804 317936010219 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 317936010220 Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936 317936010221 active site 317936010222 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 317936010223 acyl-CoA synthetase; Validated; Region: PRK05850 317936010224 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 317936010225 acyl-activating enzyme (AAE) consensus motif; other site 317936010226 active site 317936010227 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 317936010228 Condensation domain; Region: Condensation; pfam00668 317936010229 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 317936010231 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 317936010232 acyl-activating enzyme (AAE) consensus motif; other site 317936010233 AMP binding site [chemical binding]; other site 317936010234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010235 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 317936010236 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 317936010237 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 317936010238 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 317936010239 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 317936010240 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010241 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 317936010242 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 317936010243 active site 317936010244 FkbH-like domain; Region: FkbH; TIGR01686 317936010245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936010246 active site 317936010247 motif I; other site 317936010248 motif II; other site 317936010249 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936010250 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 317936010251 active site 317936010252 Acyl transferase domain; Region: Acyl_transf_1; cl08282 317936010253 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 317936010254 putative NADP binding site [chemical binding]; other site 317936010255 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 317936010256 active site 317936010257 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010258 Condensation domain; Region: Condensation; pfam00668 317936010259 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010260 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 317936010261 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 317936010262 inhibitor-cofactor binding pocket; inhibition site 317936010263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936010264 catalytic residue [active] 317936010265 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 317936010266 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 317936010267 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 317936010268 acyl-activating enzyme (AAE) consensus motif; other site 317936010269 AMP binding site [chemical binding]; other site 317936010270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010271 Condensation domain; Region: Condensation; pfam00668 317936010272 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010273 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 317936010274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 317936010275 acyl-activating enzyme (AAE) consensus motif; other site 317936010276 AMP binding site [chemical binding]; other site 317936010277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936010279 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 317936010280 active site 317936010281 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 317936010282 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 317936010283 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010284 Condensation domain; Region: Condensation; pfam00668 317936010285 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010286 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 317936010287 Condensation domain; Region: Condensation; pfam00668 317936010288 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010289 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 317936010290 acyl-activating enzyme (AAE) consensus motif; other site 317936010291 AMP binding site [chemical binding]; other site 317936010292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936010293 S-adenosylmethionine binding site [chemical binding]; other site 317936010294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 317936010295 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010296 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936010297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936010298 catalytic residue [active] 317936010299 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 317936010300 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 317936010301 active site 317936010302 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 317936010303 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 317936010304 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 317936010305 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 317936010306 putative NADP binding site [chemical binding]; other site 317936010307 active site 317936010308 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010309 Condensation domain; Region: Condensation; pfam00668 317936010310 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 317936010311 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 317936010312 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 317936010313 acyl-activating enzyme (AAE) consensus motif; other site 317936010314 AMP binding site [chemical binding]; other site 317936010315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 317936010316 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 317936010317 Cytochrome P450; Region: p450; cl12078 317936010318 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936010319 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 317936010320 short chain dehydrogenase; Provisional; Region: PRK06914 317936010321 NADP binding site [chemical binding]; other site 317936010322 active site 317936010323 steroid binding site; other site 317936010324 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 317936010325 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 317936010326 putative dimer interface [polypeptide binding]; other site 317936010327 putative [2Fe-2S] cluster binding site [ion binding]; other site 317936010328 short chain dehydrogenase; Provisional; Region: PRK06180 317936010329 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 317936010330 NADP binding site [chemical binding]; other site 317936010331 active site 317936010332 steroid binding site; other site 317936010333 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 317936010334 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936010335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936010336 AMIN domain; Region: AMIN; pfam11741 317936010337 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 317936010338 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936010339 N-terminal plug; other site 317936010340 ligand-binding site [chemical binding]; other site 317936010341 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 317936010342 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 317936010343 siderophore binding site; other site 317936010344 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936010345 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936010346 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936010347 Walker A/P-loop; other site 317936010348 ATP binding site [chemical binding]; other site 317936010349 Q-loop/lid; other site 317936010350 ABC transporter signature motif; other site 317936010351 Walker B; other site 317936010352 D-loop; other site 317936010353 H-loop/switch region; other site 317936010354 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 317936010355 H+ Antiporter protein; Region: 2A0121; TIGR00900 317936010356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936010357 putative substrate translocation pore; other site 317936010358 Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249 317936010359 Caspase domain; Region: Peptidase_C14; pfam00656 317936010360 GUN4-like; Region: GUN4; pfam05419 317936010361 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 317936010362 dimerization interface [polypeptide binding]; other site 317936010363 putative DNA binding site [nucleotide binding]; other site 317936010364 putative Zn2+ binding site [ion binding]; other site 317936010365 Predicted permeases [General function prediction only]; Region: COG0730 317936010366 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 317936010367 active site residue [active] 317936010368 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 317936010369 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 317936010370 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 317936010371 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 317936010372 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 317936010373 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 317936010374 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 317936010375 cytochrome b subunit interaction site [polypeptide binding]; other site 317936010376 [2Fe-2S] cluster binding site [ion binding]; other site 317936010377 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 317936010378 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 317936010379 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 317936010380 Predicted permeases [General function prediction only]; Region: COG0701 317936010381 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 317936010382 active site residue [active] 317936010383 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 317936010384 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 317936010385 active site 317936010386 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 317936010387 active site 317936010388 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 317936010389 chaperone protein DnaJ; Provisional; Region: PRK14299 317936010390 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936010391 HSP70 interaction site [polypeptide binding]; other site 317936010392 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 317936010393 substrate binding site [polypeptide binding]; other site 317936010394 dimer interface [polypeptide binding]; other site 317936010395 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 317936010396 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 317936010397 Ion channel; Region: Ion_trans_2; pfam07885 317936010398 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 317936010399 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 317936010400 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936010401 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 317936010402 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936010403 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 317936010404 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 317936010405 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936010406 putative active site [active] 317936010407 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010408 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 317936010409 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 317936010410 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 317936010411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 317936010412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936010413 Walker A/P-loop; other site 317936010414 ATP binding site [chemical binding]; other site 317936010415 Q-loop/lid; other site 317936010416 ABC transporter signature motif; other site 317936010417 Walker B; other site 317936010418 D-loop; other site 317936010419 H-loop/switch region; other site 317936010420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936010421 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 317936010422 FtsX-like permease family; Region: FtsX; pfam02687 317936010423 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936010424 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936010425 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936010426 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 317936010427 Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184 317936010428 quinolinate synthetase; Provisional; Region: PRK09375 317936010429 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 317936010430 putative active site [active] 317936010431 Uncharacterized integral membrane protein [Function unknown]; Region: COG5413 317936010432 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 317936010433 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 317936010434 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 317936010435 dimer interface [polypeptide binding]; other site 317936010436 anticodon binding site; other site 317936010437 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 317936010438 homodimer interface [polypeptide binding]; other site 317936010439 motif 1; other site 317936010440 active site 317936010441 motif 2; other site 317936010442 GAD domain; Region: GAD; pfam02938 317936010443 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 317936010444 motif 3; other site 317936010445 shikimate kinase; Reviewed; Region: aroK; PRK00131 317936010446 AAA domain; Region: AAA_17; pfam13207 317936010447 heat shock protein HtpX; Provisional; Region: PRK03982 317936010448 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 317936010449 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 317936010450 putative active site [active] 317936010451 putative metal binding site [ion binding]; other site 317936010452 EamA-like transporter family; Region: EamA; pfam00892 317936010453 EamA-like transporter family; Region: EamA; pfam00892 317936010454 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936010455 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936010456 bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500 317936010457 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 317936010458 active site 317936010459 dimer interface [polypeptide binding]; other site 317936010460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936010461 active site 317936010462 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 317936010463 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 317936010464 PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990 317936010465 protein binding site [polypeptide binding]; other site 317936010466 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936010467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936010468 ligand binding site [chemical binding]; other site 317936010469 flexible hinge region; other site 317936010470 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 317936010471 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936010472 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936010473 Hexamer interface [polypeptide binding]; other site 317936010474 Hexagonal pore residue; other site 317936010475 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 317936010476 Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057 317936010477 Hexamer interface [polypeptide binding]; other site 317936010478 Hexagonal pore residue; other site 317936010479 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936010480 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 317936010481 ChaB; Region: ChaB; pfam06150 317936010482 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 317936010483 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 317936010484 dimerization interface [polypeptide binding]; other site 317936010485 DPS ferroxidase diiron center [ion binding]; other site 317936010486 ion pore; other site 317936010487 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 317936010488 Active_site [active] 317936010489 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 317936010490 active site 317936010491 catalytic triad [active] 317936010492 oxyanion hole [active] 317936010493 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 317936010494 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 317936010495 dimer interface [polypeptide binding]; other site 317936010496 PYR/PP interface [polypeptide binding]; other site 317936010497 TPP binding site [chemical binding]; other site 317936010498 substrate binding site [chemical binding]; other site 317936010499 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 317936010500 Domain of unknown function; Region: EKR; pfam10371 317936010501 4Fe-4S binding domain; Region: Fer4_6; pfam12837 317936010502 4Fe-4S binding domain; Region: Fer4; pfam00037 317936010503 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 317936010504 TPP-binding site [chemical binding]; other site 317936010505 dimer interface [polypeptide binding]; other site 317936010506 Predicted membrane protein [Function unknown]; Region: COG2149 317936010507 hypothetical protein; Provisional; Region: PRK05409 317936010508 TIGR04222 domain; Region: near_uncomplex 317936010509 TIGR04222 domain; Region: near_uncomplex 317936010510 TIGR04222 domain; Region: near_uncomplex 317936010511 Ion transport protein; Region: Ion_trans; pfam00520 317936010512 Ion channel; Region: Ion_trans_2; pfam07885 317936010513 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 317936010514 Double zinc ribbon; Region: DZR; pfam12773 317936010515 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 317936010516 nucleoside/Zn binding site; other site 317936010517 dimer interface [polypeptide binding]; other site 317936010518 catalytic motif [active] 317936010519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936010520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010521 active site 317936010522 phosphorylation site [posttranslational modification] 317936010523 intermolecular recognition site; other site 317936010524 dimerization interface [polypeptide binding]; other site 317936010525 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936010526 DNA binding residues [nucleotide binding] 317936010527 dimerization interface [polypeptide binding]; other site 317936010528 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 317936010529 Histidine kinase; Region: HisKA_3; pfam07730 317936010530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010531 ATP binding site [chemical binding]; other site 317936010532 Mg2+ binding site [ion binding]; other site 317936010533 G-X-G motif; other site 317936010534 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 317936010535 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 317936010536 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 317936010537 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 317936010538 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936010539 catalytic triad [active] 317936010540 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 317936010541 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 317936010542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936010544 dimerization interface [polypeptide binding]; other site 317936010545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010546 dimer interface [polypeptide binding]; other site 317936010547 phosphorylation site [posttranslational modification] 317936010548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010549 ATP binding site [chemical binding]; other site 317936010550 Mg2+ binding site [ion binding]; other site 317936010551 G-X-G motif; other site 317936010552 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936010553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010554 active site 317936010555 phosphorylation site [posttranslational modification] 317936010556 intermolecular recognition site; other site 317936010557 dimerization interface [polypeptide binding]; other site 317936010558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936010559 DNA binding site [nucleotide binding] 317936010560 Uncharacterized conserved protein [Function unknown]; Region: COG1432 317936010561 LabA_like proteins; Region: LabA; cd10911 317936010562 putative metal binding site [ion binding]; other site 317936010563 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 317936010564 catalytic triad [active] 317936010565 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 317936010566 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 317936010567 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 317936010568 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 317936010569 Cupin domain; Region: Cupin_2; pfam07883 317936010570 Predicted permease [General function prediction only]; Region: COG3329 317936010571 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 317936010572 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 317936010573 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 317936010574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 317936010575 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936010576 putative active site [active] 317936010577 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 317936010578 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936010579 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936010580 Methyltransferase domain; Region: Methyltransf_26; pfam13659 317936010581 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 317936010582 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 317936010583 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 317936010584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936010585 non-specific DNA binding site [nucleotide binding]; other site 317936010586 salt bridge; other site 317936010587 sequence-specific DNA binding site [nucleotide binding]; other site 317936010588 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 317936010589 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 317936010590 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936010591 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 317936010592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936010593 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936010594 catalytic residues [active] 317936010595 Predicted membrane protein [Function unknown]; Region: COG4094 317936010596 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 317936010597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936010598 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 317936010599 putative dimerization interface [polypeptide binding]; other site 317936010600 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936010601 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010602 active site 317936010603 ATP binding site [chemical binding]; other site 317936010604 substrate binding site [chemical binding]; other site 317936010605 activation loop (A-loop); other site 317936010606 PBP superfamily domain; Region: PBP_like_2; pfam12849 317936010607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936010608 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936010609 putative switch regulator; other site 317936010610 non-specific DNA interactions [nucleotide binding]; other site 317936010611 DNA binding site [nucleotide binding] 317936010612 sequence specific DNA binding site [nucleotide binding]; other site 317936010613 putative cAMP binding site [chemical binding]; other site 317936010614 DALR anticodon binding domain; Region: DALR_1; smart00836 317936010615 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 317936010616 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936010617 active site 317936010618 motif I; other site 317936010619 motif II; other site 317936010620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936010621 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 317936010622 DHH family; Region: DHH; pfam01368 317936010623 DHHA1 domain; Region: DHHA1; pfam02272 317936010624 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 317936010625 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 317936010626 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 317936010627 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 317936010628 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 317936010629 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 317936010630 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 317936010631 catalytic residues [active] 317936010632 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 317936010633 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 317936010634 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936010635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936010636 active site 317936010637 phosphorylation site [posttranslational modification] 317936010638 intermolecular recognition site; other site 317936010639 dimerization interface [polypeptide binding]; other site 317936010640 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936010641 DNA binding site [nucleotide binding] 317936010642 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936010643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010644 dimer interface [polypeptide binding]; other site 317936010645 phosphorylation site [posttranslational modification] 317936010646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010647 ATP binding site [chemical binding]; other site 317936010648 Mg2+ binding site [ion binding]; other site 317936010649 G-X-G motif; other site 317936010650 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 317936010651 PhoU domain; Region: PhoU; pfam01895 317936010652 PhoU domain; Region: PhoU; pfam01895 317936010653 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 317936010654 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936010655 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 317936010656 ligand binding site [chemical binding]; other site 317936010657 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936010658 putative switch regulator; other site 317936010659 non-specific DNA interactions [nucleotide binding]; other site 317936010660 DNA binding site [nucleotide binding] 317936010661 sequence specific DNA binding site [nucleotide binding]; other site 317936010662 putative cAMP binding site [chemical binding]; other site 317936010663 S-layer homology domain; Region: SLH; pfam00395 317936010664 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936010665 S-layer homology domain; Region: SLH; pfam00395 317936010666 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936010667 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 317936010668 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936010669 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936010670 active site 317936010671 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936010672 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 317936010673 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 317936010674 Ligand binding site; other site 317936010675 Putative Catalytic site; other site 317936010676 DXD motif; other site 317936010677 Predicted membrane protein [Function unknown]; Region: COG2246 317936010678 GtrA-like protein; Region: GtrA; pfam04138 317936010679 FO synthase subunit 2; Reviewed; Region: PRK07360 317936010680 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936010681 FeS/SAM binding site; other site 317936010682 photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044 317936010683 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936010684 DNA polymerase I; Provisional; Region: PRK05755 317936010685 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 317936010686 active site 317936010687 metal binding site 1 [ion binding]; metal-binding site 317936010688 putative 5' ssDNA interaction site; other site 317936010689 metal binding site 3; metal-binding site 317936010690 metal binding site 2 [ion binding]; metal-binding site 317936010691 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 317936010692 putative DNA binding site [nucleotide binding]; other site 317936010693 putative metal binding site [ion binding]; other site 317936010694 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 317936010695 active site 317936010696 catalytic site [active] 317936010697 substrate binding site [chemical binding]; other site 317936010698 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 317936010699 active site 317936010700 DNA binding site [nucleotide binding] 317936010701 catalytic site [active] 317936010702 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 317936010703 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 317936010704 ligand binding site; other site 317936010705 oligomer interface; other site 317936010706 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 317936010707 dimer interface [polypeptide binding]; other site 317936010708 N-terminal domain interface [polypeptide binding]; other site 317936010709 sulfate 1 binding site; other site 317936010710 AAA domain; Region: AAA_33; pfam13671 317936010711 L-seryl-tRNA(Sec) kinase, eukaryotic; Region: selen_PSTK_euk; TIGR03575 317936010712 chaperone protein DnaJ; Provisional; Region: PRK14299 317936010713 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 317936010714 HSP70 interaction site [polypeptide binding]; other site 317936010715 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 317936010716 substrate binding site [polypeptide binding]; other site 317936010717 dimer interface [polypeptide binding]; other site 317936010718 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936010719 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 317936010720 C-terminal domain interface [polypeptide binding]; other site 317936010721 GSH binding site (G-site) [chemical binding]; other site 317936010722 dimer interface [polypeptide binding]; other site 317936010723 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 317936010724 N-terminal domain interface [polypeptide binding]; other site 317936010725 dimer interface [polypeptide binding]; other site 317936010726 substrate binding pocket (H-site) [chemical binding]; other site 317936010727 Uncharacterized conserved protein [Function unknown]; Region: COG0062 317936010728 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 317936010729 putative substrate binding site [chemical binding]; other site 317936010730 putative ATP binding site [chemical binding]; other site 317936010731 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 317936010732 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 317936010733 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 317936010734 ATP-sulfurylase; Region: ATPS; cd00517 317936010735 active site 317936010736 HXXH motif; other site 317936010737 flexible loop; other site 317936010738 Caspase domain; Region: Peptidase_C14; pfam00656 317936010739 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 317936010740 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936010741 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 317936010742 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 317936010743 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 317936010744 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 317936010745 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 317936010746 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 317936010747 dimerization interface [polypeptide binding]; other site 317936010748 active site 317936010749 metal binding site [ion binding]; metal-binding site 317936010750 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 317936010751 anti sigma factor interaction site; other site 317936010752 regulatory phosphorylation site [posttranslational modification]; other site 317936010753 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 317936010754 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 317936010755 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 317936010756 catalytic site [active] 317936010757 subunit interface [polypeptide binding]; other site 317936010758 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 317936010759 catalytic motif [active] 317936010760 Catalytic residue [active] 317936010761 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 317936010762 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 317936010763 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 317936010764 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 317936010765 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 317936010766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936010767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936010768 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 317936010769 G1 box; other site 317936010770 GTP/Mg2+ binding site [chemical binding]; other site 317936010771 G2 box; other site 317936010772 PAS fold; Region: PAS_4; pfam08448 317936010773 PAS domain S-box; Region: sensory_box; TIGR00229 317936010774 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936010775 putative active site [active] 317936010776 heme pocket [chemical binding]; other site 317936010777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010779 dimer interface [polypeptide binding]; other site 317936010780 phosphorylation site [posttranslational modification] 317936010781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010782 ATP binding site [chemical binding]; other site 317936010783 Mg2+ binding site [ion binding]; other site 317936010784 G-X-G motif; other site 317936010785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936010786 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 317936010787 active site 317936010788 metal binding site [ion binding]; metal-binding site 317936010789 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233 317936010790 putative active site [active] 317936010791 Zn binding site [ion binding]; other site 317936010792 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 317936010793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936010794 active site 317936010795 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936010796 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936010797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936010798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936010799 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936010800 Walker A/P-loop; other site 317936010801 ATP binding site [chemical binding]; other site 317936010802 Q-loop/lid; other site 317936010803 ABC transporter signature motif; other site 317936010804 Walker B; other site 317936010805 D-loop; other site 317936010806 H-loop/switch region; other site 317936010807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936010808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936010809 Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852 317936010810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936010811 Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051 317936010812 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 317936010813 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 317936010814 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 317936010815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 317936010816 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 317936010817 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 317936010818 Walker A motif; other site 317936010819 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936010820 protein-splicing catalytic site; other site 317936010821 thioester formation/cholesterol transfer; other site 317936010822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936010823 non-specific DNA binding site [nucleotide binding]; other site 317936010824 salt bridge; other site 317936010825 sequence-specific DNA binding site [nucleotide binding]; other site 317936010826 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936010827 protein-splicing catalytic site; other site 317936010828 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 317936010829 Walker B motif; other site 317936010830 DNA binding loops [nucleotide binding] 317936010831 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936010832 protein-splicing catalytic site; other site 317936010833 thioester formation/cholesterol transfer; other site 317936010834 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 317936010835 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 317936010836 protein-splicing catalytic site; other site 317936010837 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 317936010838 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 317936010839 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 317936010840 Uncharacterized conserved protein [Function unknown]; Region: COG3937 317936010841 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 317936010842 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 317936010843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936010844 TPR motif; other site 317936010845 binding surface 317936010846 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 317936010847 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 317936010848 active site residue [active] 317936010849 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 317936010850 Phage protein D [General function prediction only]; Region: COG3500 317936010851 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 317936010852 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 317936010853 PAAR motif; Region: PAAR_motif; pfam05488 317936010854 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010855 GAF domain; Region: GAF_3; pfam13492 317936010856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936010857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936010858 dimer interface [polypeptide binding]; other site 317936010859 phosphorylation site [posttranslational modification] 317936010860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936010861 ATP binding site [chemical binding]; other site 317936010862 Mg2+ binding site [ion binding]; other site 317936010863 G-X-G motif; other site 317936010864 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010865 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936010866 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936010867 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 317936010868 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 317936010869 phage tail protein domain; Region: tail_TIGR02242 317936010870 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 317936010871 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936010872 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 317936010873 structural tetrad; other site 317936010874 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 317936010875 PgaD-like protein; Region: PgaD; cl14676 317936010876 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010877 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936010878 binding surface 317936010879 TPR motif; other site 317936010880 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010881 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010882 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936010883 binding surface 317936010884 TPR motif; other site 317936010885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936010886 binding surface 317936010887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010888 TPR motif; other site 317936010889 CHAT domain; Region: CHAT; pfam12770 317936010890 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 317936010891 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936010892 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936010893 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936010894 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 317936010895 Mg++ binding site [ion binding]; other site 317936010896 AAA ATPase domain; Region: AAA_16; pfam13191 317936010897 AAA domain; Region: AAA_22; pfam13401 317936010898 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936010899 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936010900 ligand binding site [chemical binding]; other site 317936010901 flexible hinge region; other site 317936010902 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 317936010903 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 317936010904 putative NAD(P) binding site [chemical binding]; other site 317936010905 active site 317936010906 TrkA-N domain; Region: TrkA_N; pfam02254 317936010907 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 317936010908 TrkA-N domain; Region: TrkA_N; pfam02254 317936010909 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 317936010910 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 317936010911 Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150 317936010912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936010913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936010914 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 317936010915 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936010916 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936010917 TPR repeat; Region: TPR_11; pfam13414 317936010918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936010919 binding surface 317936010920 TPR motif; other site 317936010921 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936010922 CHASE2 domain; Region: CHASE2; pfam05226 317936010923 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936010924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936010925 active site 317936010926 ATP binding site [chemical binding]; other site 317936010927 substrate binding site [chemical binding]; other site 317936010928 activation loop (A-loop); other site 317936010929 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 317936010930 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 317936010931 E-class dimer interface [polypeptide binding]; other site 317936010932 P-class dimer interface [polypeptide binding]; other site 317936010933 active site 317936010934 Cu2+ binding site [ion binding]; other site 317936010935 Zn2+ binding site [ion binding]; other site 317936010936 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010937 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936010938 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010939 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936010940 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936010943 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936010944 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936010945 phosphopeptide binding site; other site 317936010946 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 317936010947 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 317936010948 FAD binding pocket [chemical binding]; other site 317936010949 FAD binding motif [chemical binding]; other site 317936010950 phosphate binding motif [ion binding]; other site 317936010951 beta-alpha-beta structure motif; other site 317936010952 NAD binding pocket [chemical binding]; other site 317936010953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936010954 catalytic loop [active] 317936010955 iron binding site [ion binding]; other site 317936010956 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936010957 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936010958 phosphopeptide binding site; other site 317936010959 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936010960 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936010961 ligand binding site [chemical binding]; other site 317936010962 flexible hinge region; other site 317936010963 Tetratricopeptide repeat; Region: TPR_2; pfam07719 317936010964 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936010965 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936010966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 317936010967 active site 317936010968 metal binding site [ion binding]; metal-binding site 317936010969 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936010970 CpeS-like protein; Region: CpeS; pfam09367 317936010971 HEAT repeats; Region: HEAT_2; pfam13646 317936010972 HEAT repeats; Region: HEAT_2; pfam13646 317936010973 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 317936010974 HEAT repeats; Region: HEAT_2; pfam13646 317936010975 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 317936010976 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 317936010977 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936010978 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936010979 phosphopeptide binding site; other site 317936010980 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936010981 GAF domain; Region: GAF; pfam01590 317936010982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936010983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936010984 metal binding site [ion binding]; metal-binding site 317936010985 active site 317936010986 I-site; other site 317936010987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936010988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936010989 Coenzyme A binding pocket [chemical binding]; other site 317936010990 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 317936010991 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936010992 active site 317936010993 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 317936010994 cobalamin synthase; Reviewed; Region: cobS; PRK00235 317936010995 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 317936010996 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 317936010997 Helix-turn-helix domain; Region: HTH_17; pfam12728 317936010998 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936010999 oligomeric interface; other site 317936011000 homodimer interface [polypeptide binding]; other site 317936011001 putative active site [active] 317936011002 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 317936011003 homodimer interface [polypeptide binding]; other site 317936011004 substrate-cofactor binding pocket; other site 317936011005 Aminotransferase class IV; Region: Aminotran_4; pfam01063 317936011006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936011007 catalytic residue [active] 317936011008 FtsH Extracellular; Region: FtsH_ext; pfam06480 317936011009 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 317936011010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936011011 Walker A motif; other site 317936011012 ATP binding site [chemical binding]; other site 317936011013 Walker B motif; other site 317936011014 arginine finger; other site 317936011015 Peptidase family M41; Region: Peptidase_M41; pfam01434 317936011016 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936011017 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936011018 structural tetrad; other site 317936011019 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936011020 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936011021 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936011022 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 317936011023 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 317936011024 intersubunit interface [polypeptide binding]; other site 317936011025 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936011026 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936011027 structural tetrad; other site 317936011028 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 317936011029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936011030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011031 active site 317936011032 phosphorylation site [posttranslational modification] 317936011033 intermolecular recognition site; other site 317936011034 dimerization interface [polypeptide binding]; other site 317936011035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936011036 DNA binding site [nucleotide binding] 317936011037 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936011038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011039 active site 317936011040 phosphorylation site [posttranslational modification] 317936011041 intermolecular recognition site; other site 317936011042 dimerization interface [polypeptide binding]; other site 317936011043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936011045 dimerization interface [polypeptide binding]; other site 317936011046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936011047 dimer interface [polypeptide binding]; other site 317936011048 phosphorylation site [posttranslational modification] 317936011049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011050 ATP binding site [chemical binding]; other site 317936011051 Mg2+ binding site [ion binding]; other site 317936011052 G-X-G motif; other site 317936011053 Protein of unknown function (DUF2874); Region: DUF2874; pfam11396 317936011054 S-layer homology domain; Region: SLH; pfam00395 317936011055 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936011056 Response regulator receiver domain; Region: Response_reg; pfam00072 317936011057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011058 active site 317936011059 phosphorylation site [posttranslational modification] 317936011060 intermolecular recognition site; other site 317936011061 dimerization interface [polypeptide binding]; other site 317936011062 glycerate kinase; Region: TIGR00045 317936011063 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 317936011064 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 317936011065 transmembrane helices; other site 317936011066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 317936011067 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 317936011068 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 317936011069 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936011070 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936011071 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936011072 ligand binding site [chemical binding]; other site 317936011073 flexible hinge region; other site 317936011074 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 317936011075 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 317936011076 putative active site [active] 317936011077 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936011078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936011079 Walker A/P-loop; other site 317936011080 ATP binding site [chemical binding]; other site 317936011081 Q-loop/lid; other site 317936011082 ABC transporter signature motif; other site 317936011083 Walker B; other site 317936011084 D-loop; other site 317936011085 H-loop/switch region; other site 317936011086 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 317936011087 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 317936011088 dinuclear metal binding motif [ion binding]; other site 317936011089 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 317936011090 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 317936011091 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 317936011092 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 317936011093 putative NADP binding site [chemical binding]; other site 317936011094 putative substrate binding site [chemical binding]; other site 317936011095 active site 317936011096 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 317936011097 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936011098 FeS/SAM binding site; other site 317936011099 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 317936011100 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 317936011101 Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562 317936011102 substrate binding pocket [chemical binding]; other site 317936011103 substrate-Mg2+ binding site; other site 317936011104 aspartate-rich region 1; other site 317936011105 aspartate-rich region 2; other site 317936011106 aspartate aminotransferase; Provisional; Region: PRK05942 317936011107 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936011108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936011109 homodimer interface [polypeptide binding]; other site 317936011110 catalytic residue [active] 317936011111 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 317936011112 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 317936011113 putative active site [active] 317936011114 metal binding site [ion binding]; metal-binding site 317936011115 Protein of function (DUF2518); Region: DUF2518; pfam10726 317936011116 O-Antigen ligase; Region: Wzy_C; cl04850 317936011117 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 317936011118 O-Antigen ligase; Region: Wzy_C; pfam04932 317936011119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 317936011120 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 317936011121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936011122 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 317936011123 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936011124 nucleotide binding site [chemical binding]; other site 317936011125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936011126 nucleotide binding site [chemical binding]; other site 317936011127 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 317936011128 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 317936011129 active site 317936011130 interdomain interaction site; other site 317936011131 putative metal-binding site [ion binding]; other site 317936011132 nucleotide binding site [chemical binding]; other site 317936011133 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 317936011134 domain I; other site 317936011135 phosphate binding site [ion binding]; other site 317936011136 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 317936011137 domain II; other site 317936011138 domain III; other site 317936011139 nucleotide binding site [chemical binding]; other site 317936011140 DNA binding groove [nucleotide binding] 317936011141 catalytic site [active] 317936011142 domain IV; other site 317936011143 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 317936011144 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 317936011145 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 317936011146 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 317936011147 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 317936011148 NodB motif; other site 317936011149 active site 317936011150 catalytic site [active] 317936011151 metal binding site [ion binding]; metal-binding site 317936011152 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936011153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936011154 non-specific DNA binding site [nucleotide binding]; other site 317936011155 salt bridge; other site 317936011156 sequence-specific DNA binding site [nucleotide binding]; other site 317936011157 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 317936011158 MltA specific insert domain; Region: MltA; pfam03562 317936011159 3D domain; Region: 3D; pfam06725 317936011160 proton extrusion protein PcxA; Provisional; Region: PRK02507 317936011161 Resolvase, N terminal domain; Region: Resolvase; smart00857 317936011162 Nidogen-like; Region: NIDO; pfam06119 317936011163 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936011164 methionine sulfoxide reductase A; Provisional; Region: PRK00058 317936011165 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 317936011166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936011167 non-specific DNA binding site [nucleotide binding]; other site 317936011168 salt bridge; other site 317936011169 sequence-specific DNA binding site [nucleotide binding]; other site 317936011170 Domain of unknown function (DUF955); Region: DUF955; pfam06114 317936011171 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 317936011172 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936011173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936011174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936011175 Walker A/P-loop; other site 317936011176 ATP binding site [chemical binding]; other site 317936011177 Q-loop/lid; other site 317936011178 ABC transporter signature motif; other site 317936011179 Walker B; other site 317936011180 D-loop; other site 317936011181 H-loop/switch region; other site 317936011182 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936011183 Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509 317936011184 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 317936011185 PhoH-like protein; Region: PhoH; pfam02562 317936011186 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 317936011187 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 317936011188 KH domain; Region: KH_4; pfam13083 317936011189 G-X-X-G motif; other site 317936011190 ribosomal protein S16; Region: rps16; CHL00005 317936011191 signal recognition particle protein; Provisional; Region: PRK10867 317936011192 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 317936011193 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 317936011194 GTP binding site [chemical binding]; other site 317936011195 Signal peptide binding domain; Region: SRP_SPB; pfam02978 317936011196 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 317936011197 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 317936011198 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 317936011199 active site 317936011200 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 317936011201 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 317936011202 heme-binding site [chemical binding]; other site 317936011203 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 317936011204 active site 317936011205 dimer interface [polypeptide binding]; other site 317936011206 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 317936011207 Flavodoxin; Region: Flavodoxin_1; pfam00258 317936011208 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 317936011209 FAD binding pocket [chemical binding]; other site 317936011210 conserved FAD binding motif [chemical binding]; other site 317936011211 phosphate binding motif [ion binding]; other site 317936011212 beta-alpha-beta structure motif; other site 317936011213 NAD binding pocket [chemical binding]; other site 317936011214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 317936011215 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936011216 oligomeric interface; other site 317936011217 putative active site [active] 317936011218 homodimer interface [polypeptide binding]; other site 317936011219 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 317936011220 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 317936011221 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011222 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011223 active site 317936011224 substrate binding site [chemical binding]; other site 317936011225 ATP binding site [chemical binding]; other site 317936011226 activation loop (A-loop); other site 317936011227 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936011228 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936011229 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936011230 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 317936011231 translation initiation factor IF-3; Region: infC; TIGR00168 317936011232 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 317936011233 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 317936011234 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011235 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011236 active site 317936011237 substrate binding site [chemical binding]; other site 317936011238 ATP binding site [chemical binding]; other site 317936011239 activation loop (A-loop); other site 317936011240 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936011241 structural tetrad; other site 317936011242 PQQ-like domain; Region: PQQ_2; pfam13360 317936011243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936011244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936011245 Walker A/P-loop; other site 317936011246 ATP binding site [chemical binding]; other site 317936011247 Q-loop/lid; other site 317936011248 ABC transporter signature motif; other site 317936011249 Walker B; other site 317936011250 D-loop; other site 317936011251 H-loop/switch region; other site 317936011252 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936011253 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936011254 magnesium chelatase, H subunit; Region: BchH; TIGR02025 317936011255 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 317936011256 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 317936011257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936011258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936011259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 317936011260 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 317936011261 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 317936011262 iron-sulfur cluster [ion binding]; other site 317936011263 [2Fe-2S] cluster binding site [ion binding]; other site 317936011264 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936011265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011266 active site 317936011267 phosphorylation site [posttranslational modification] 317936011268 intermolecular recognition site; other site 317936011269 dimerization interface [polypeptide binding]; other site 317936011270 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011271 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011272 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011273 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936011276 dimer interface [polypeptide binding]; other site 317936011277 phosphorylation site [posttranslational modification] 317936011278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011279 ATP binding site [chemical binding]; other site 317936011280 Mg2+ binding site [ion binding]; other site 317936011281 G-X-G motif; other site 317936011282 Response regulator receiver domain; Region: Response_reg; pfam00072 317936011283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011284 active site 317936011285 phosphorylation site [posttranslational modification] 317936011286 intermolecular recognition site; other site 317936011287 dimerization interface [polypeptide binding]; other site 317936011288 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936011289 cyclase homology domain; Region: CHD; cd07302 317936011290 nucleotidyl binding site; other site 317936011291 metal binding site [ion binding]; metal-binding site 317936011292 dimer interface [polypeptide binding]; other site 317936011293 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 317936011294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936011295 Coenzyme A binding pocket [chemical binding]; other site 317936011296 histidinol-phosphate aminotransferase; Provisional; Region: PRK02610 317936011297 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936011298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936011299 homodimer interface [polypeptide binding]; other site 317936011300 catalytic residue [active] 317936011301 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 317936011302 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936011303 FecR protein; Region: FecR; pfam04773 317936011304 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 317936011305 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 317936011306 active site residue [active] 317936011307 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 317936011308 active site residue [active] 317936011309 Uncharacterized conserved protein [Function unknown]; Region: COG4121 317936011310 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 317936011311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011312 active site 317936011313 phosphorylation site [posttranslational modification] 317936011314 intermolecular recognition site; other site 317936011315 dimerization interface [polypeptide binding]; other site 317936011316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 317936011317 Zn2+ binding site [ion binding]; other site 317936011318 Mg2+ binding site [ion binding]; other site 317936011319 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 317936011320 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 317936011321 Substrate binding site; other site 317936011322 Mg++ binding site; other site 317936011323 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 317936011324 active site 317936011325 substrate binding site [chemical binding]; other site 317936011326 CoA binding site [chemical binding]; other site 317936011327 Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514 317936011328 active site 317936011329 dimer interface [polypeptide binding]; other site 317936011330 catalytic nucleophile [active] 317936011331 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 317936011332 PAS fold; Region: PAS_4; pfam08448 317936011333 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011334 putative active site [active] 317936011335 heme pocket [chemical binding]; other site 317936011336 PAS domain S-box; Region: sensory_box; TIGR00229 317936011337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011338 putative active site [active] 317936011339 heme pocket [chemical binding]; other site 317936011340 PAS domain S-box; Region: sensory_box; TIGR00229 317936011341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011342 putative active site [active] 317936011343 heme pocket [chemical binding]; other site 317936011344 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936011345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011346 putative active site [active] 317936011347 heme pocket [chemical binding]; other site 317936011348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936011349 dimer interface [polypeptide binding]; other site 317936011350 phosphorylation site [posttranslational modification] 317936011351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011352 ATP binding site [chemical binding]; other site 317936011353 Mg2+ binding site [ion binding]; other site 317936011354 G-X-G motif; other site 317936011355 Protein kinase domain; Region: Pkinase; pfam00069 317936011356 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011357 active site 317936011358 ATP binding site [chemical binding]; other site 317936011359 substrate binding site [chemical binding]; other site 317936011360 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936011361 substrate binding site [chemical binding]; other site 317936011362 activation loop (A-loop); other site 317936011363 activation loop (A-loop); other site 317936011364 AAA ATPase domain; Region: AAA_16; pfam13191 317936011365 Predicted ATPase [General function prediction only]; Region: COG3899 317936011366 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011367 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011370 ATP binding site [chemical binding]; other site 317936011371 Mg2+ binding site [ion binding]; other site 317936011372 G-X-G motif; other site 317936011373 Protein kinase domain; Region: Pkinase; pfam00069 317936011374 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011375 active site 317936011376 ATP binding site [chemical binding]; other site 317936011377 substrate binding site [chemical binding]; other site 317936011378 activation loop (A-loop); other site 317936011379 AAA ATPase domain; Region: AAA_16; pfam13191 317936011380 Predicted ATPase [General function prediction only]; Region: COG3899 317936011381 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011382 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011383 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011384 PAS fold; Region: PAS_3; pfam08447 317936011385 putative active site [active] 317936011386 heme pocket [chemical binding]; other site 317936011387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011389 ATP binding site [chemical binding]; other site 317936011390 Mg2+ binding site [ion binding]; other site 317936011391 G-X-G motif; other site 317936011392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936011393 GAF domain; Region: GAF_2; pfam13185 317936011394 GAF domain; Region: GAF; pfam01590 317936011395 GAF domain; Region: GAF; pfam01590 317936011396 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011397 GAF domain; Region: GAF; pfam01590 317936011398 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 317936011399 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 317936011400 quinone interaction residues [chemical binding]; other site 317936011401 active site 317936011402 catalytic residues [active] 317936011403 FMN binding site [chemical binding]; other site 317936011404 substrate binding site [chemical binding]; other site 317936011405 TROVE domain; Region: TROVE; pfam05731 317936011406 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 317936011407 metal ion-dependent adhesion site (MIDAS); other site 317936011408 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936011409 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936011410 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936011411 AAA ATPase domain; Region: AAA_16; pfam13191 317936011412 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936011413 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936011414 CHASE2 domain; Region: CHASE2; pfam05226 317936011415 Protein kinase domain; Region: Pkinase; pfam00069 317936011416 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011417 active site 317936011418 ATP binding site [chemical binding]; other site 317936011419 substrate binding site [chemical binding]; other site 317936011420 activation loop (A-loop); other site 317936011421 Uncharacterized conserved protein [Function unknown]; Region: COG1432 317936011422 LabA_like proteins; Region: LabA; cd10911 317936011423 putative metal binding site [ion binding]; other site 317936011424 2-isopropylmalate synthase; Validated; Region: PRK00915 317936011425 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 317936011426 active site 317936011427 catalytic residues [active] 317936011428 metal binding site [ion binding]; metal-binding site 317936011429 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 317936011430 diaminopimelate epimerase; Provisional; Region: PRK13577 317936011431 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 317936011432 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 317936011433 DEAD-like helicases superfamily; Region: DEXDc; smart00487 317936011434 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936011435 ATP binding site [chemical binding]; other site 317936011436 putative Mg++ binding site [ion binding]; other site 317936011437 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936011438 nucleotide binding region [chemical binding]; other site 317936011439 ATP-binding site [chemical binding]; other site 317936011440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 317936011441 Uncharacterized conserved protein [Function unknown]; Region: COG2442 317936011442 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 317936011443 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 317936011444 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 317936011445 dimer interface [polypeptide binding]; other site 317936011446 motif 1; other site 317936011447 active site 317936011448 motif 2; other site 317936011449 motif 3; other site 317936011450 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 317936011451 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 317936011452 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 317936011453 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 317936011454 active site 317936011455 Riboflavin kinase; Region: Flavokinase; pfam01687 317936011456 MoxR-like ATPases [General function prediction only]; Region: COG0714 317936011457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936011458 Walker A motif; other site 317936011459 ATP binding site [chemical binding]; other site 317936011460 Walker B motif; other site 317936011461 arginine finger; other site 317936011462 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 317936011463 S-layer homology domain; Region: SLH; pfam00395 317936011464 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936011465 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 317936011466 aromatic arch; other site 317936011467 DCoH dimer interaction site [polypeptide binding]; other site 317936011468 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 317936011469 DCoH tetramer interaction site [polypeptide binding]; other site 317936011470 substrate binding site [chemical binding]; other site 317936011471 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 317936011472 D1 interface; other site 317936011473 chlorophyll binding site; other site 317936011474 pheophytin binding site; other site 317936011475 beta carotene binding site; other site 317936011476 cytochrome b559 beta interface; other site 317936011477 quinone binding site; other site 317936011478 cytochrome b559 alpha interface; other site 317936011479 protein J interface; other site 317936011480 protein H interface; other site 317936011481 protein X interface; other site 317936011482 core light harvesting protein interface; other site 317936011483 protein L interface; other site 317936011484 CP43 interface; other site 317936011485 protein T interface; other site 317936011486 Fe binding site [ion binding]; other site 317936011487 protein M interface; other site 317936011488 Mn-stabilizing polypeptide interface; other site 317936011489 bromide binding site; other site 317936011490 cytochrome c-550 interface; other site 317936011491 hypothetical protein; Provisional; Region: PRK13683 317936011492 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 317936011493 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 317936011494 Walker A/P-loop; other site 317936011495 ATP binding site [chemical binding]; other site 317936011496 Q-loop/lid; other site 317936011497 ABC transporter signature motif; other site 317936011498 Walker B; other site 317936011499 D-loop; other site 317936011500 H-loop/switch region; other site 317936011501 YacP-like NYN domain; Region: NYN_YacP; cl01491 317936011502 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 317936011503 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 317936011504 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936011505 catalytic residue [active] 317936011506 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 317936011507 dinuclear metal binding motif [ion binding]; other site 317936011508 glutamine synthetase, type I; Region: GlnA; TIGR00653 317936011509 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 317936011510 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 317936011511 allophycocyanin, beta subunit; Region: apcB; TIGR01337 317936011512 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 317936011513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936011514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936011515 homodimer interface [polypeptide binding]; other site 317936011516 catalytic residue [active] 317936011517 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936011518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936011519 S-adenosylmethionine binding site [chemical binding]; other site 317936011520 hypothetical protein; Provisional; Region: PRK06185 317936011521 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 317936011522 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 317936011523 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 317936011524 Walker A/P-loop; other site 317936011525 ATP binding site [chemical binding]; other site 317936011526 Q-loop/lid; other site 317936011527 ABC transporter signature motif; other site 317936011528 Walker B; other site 317936011529 D-loop; other site 317936011530 H-loop/switch region; other site 317936011531 TOBE domain; Region: TOBE_2; pfam08402 317936011532 S-layer homology domain; Region: SLH; pfam00395 317936011533 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936011534 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936011535 putative active site [active] 317936011536 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 317936011537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 317936011538 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936011539 putative active site [active] 317936011540 GTPase CgtA; Reviewed; Region: obgE; PRK12299 317936011541 GTP1/OBG; Region: GTP1_OBG; pfam01018 317936011542 Obg GTPase; Region: Obg; cd01898 317936011543 G1 box; other site 317936011544 GTP/Mg2+ binding site [chemical binding]; other site 317936011545 Switch I region; other site 317936011546 G2 box; other site 317936011547 G3 box; other site 317936011548 Switch II region; other site 317936011549 G4 box; other site 317936011550 G5 box; other site 317936011551 tellurium resistance terB-like protein; Region: terB_like; cd07177 317936011552 metal binding site [ion binding]; metal-binding site 317936011553 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 317936011554 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 317936011555 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 317936011556 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 317936011557 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 317936011558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936011559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936011560 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 317936011561 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936011562 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936011563 DevC protein; Region: devC; TIGR01185 317936011564 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936011565 FtsX-like permease family; Region: FtsX; pfam02687 317936011566 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 317936011567 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936011568 Walker A/P-loop; other site 317936011569 ATP binding site [chemical binding]; other site 317936011570 Q-loop/lid; other site 317936011571 ABC transporter signature motif; other site 317936011572 Walker B; other site 317936011573 D-loop; other site 317936011574 H-loop/switch region; other site 317936011575 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 317936011576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936011577 S-adenosylmethionine binding site [chemical binding]; other site 317936011578 Peptidase family M48; Region: Peptidase_M48; cl12018 317936011579 SnoaL-like domain; Region: SnoaL_4; pfam13577 317936011580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011581 active site 317936011582 ATP binding site [chemical binding]; other site 317936011583 substrate binding site [chemical binding]; other site 317936011584 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011585 activation loop (A-loop); other site 317936011586 AAA ATPase domain; Region: AAA_16; pfam13191 317936011587 Predicted ATPase [General function prediction only]; Region: COG3899 317936011588 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936011589 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936011591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011592 dimer interface [polypeptide binding]; other site 317936011593 phosphorylation site [posttranslational modification] 317936011594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011595 ATP binding site [chemical binding]; other site 317936011596 Mg2+ binding site [ion binding]; other site 317936011597 G-X-G motif; other site 317936011598 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 317936011599 NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415 317936011600 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 317936011601 active site 317936011602 dimer interface [polypeptide binding]; other site 317936011603 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 317936011604 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 317936011605 active site 317936011606 HIGH motif; other site 317936011607 dimer interface [polypeptide binding]; other site 317936011608 KMSKS motif; other site 317936011609 Transglycosylase; Region: Transgly; pfam00912 317936011610 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 317936011611 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 317936011612 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 317936011613 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 317936011614 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 317936011615 MoaE interaction surface [polypeptide binding]; other site 317936011616 MoeB interaction surface [polypeptide binding]; other site 317936011617 thiocarboxylated glycine; other site 317936011618 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 317936011619 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936011620 N-terminal plug; other site 317936011621 ligand-binding site [chemical binding]; other site 317936011622 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 317936011623 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936011624 binding surface 317936011625 TPR motif; other site 317936011626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936011627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936011628 binding surface 317936011629 TPR motif; other site 317936011630 cytochrome c6; Provisional; Region: PRK13697 317936011631 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 317936011632 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936011633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011634 putative active site [active] 317936011635 heme pocket [chemical binding]; other site 317936011636 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936011637 PAS domain; Region: PAS_9; pfam13426 317936011638 putative active site [active] 317936011639 heme pocket [chemical binding]; other site 317936011640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011642 ATP binding site [chemical binding]; other site 317936011643 Mg2+ binding site [ion binding]; other site 317936011644 G-X-G motif; other site 317936011645 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 317936011646 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936011647 Coenzyme A binding pocket [chemical binding]; other site 317936011648 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936011649 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 317936011650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936011651 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936011652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936011653 DNA binding residues [nucleotide binding] 317936011654 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 317936011655 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936011656 ATP binding site [chemical binding]; other site 317936011657 putative Mg++ binding site [ion binding]; other site 317936011658 helicase superfamily c-terminal domain; Region: HELICc; smart00490 317936011659 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 317936011660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 317936011661 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 317936011662 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 317936011663 seryl-tRNA synthetase; Provisional; Region: PRK05431 317936011664 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 317936011665 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 317936011666 dimer interface [polypeptide binding]; other site 317936011667 active site 317936011668 motif 1; other site 317936011669 motif 2; other site 317936011670 motif 3; other site 317936011671 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 317936011672 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 317936011673 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 317936011674 NAD(P) binding site [chemical binding]; other site 317936011675 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 317936011676 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 317936011677 folate/biopterin transporter; Region: fbt; TIGR00788 317936011678 BT1 family; Region: BT1; pfam03092 317936011679 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936011680 CHASE2 domain; Region: CHASE2; pfam05226 317936011681 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936011682 cyclase homology domain; Region: CHD; cd07302 317936011683 nucleotidyl binding site; other site 317936011684 metal binding site [ion binding]; metal-binding site 317936011685 dimer interface [polypeptide binding]; other site 317936011686 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936011687 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936011688 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936011689 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 317936011690 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011691 Phytochrome region; Region: PHY; pfam00360 317936011692 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936011693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936011694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936011695 dimer interface [polypeptide binding]; other site 317936011696 phosphorylation site [posttranslational modification] 317936011697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011698 ATP binding site [chemical binding]; other site 317936011699 Mg2+ binding site [ion binding]; other site 317936011700 G-X-G motif; other site 317936011701 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 317936011702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936011703 active site 317936011704 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 317936011705 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 317936011706 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 317936011707 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 317936011708 putative dimer interface [polypeptide binding]; other site 317936011709 N-terminal domain interface [polypeptide binding]; other site 317936011710 putative substrate binding pocket (H-site) [chemical binding]; other site 317936011711 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 317936011712 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 317936011713 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 317936011714 Ligand Binding Site [chemical binding]; other site 317936011715 K+-transporting ATPase, c chain; Region: KdpC; cl00944 317936011716 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 317936011717 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936011718 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936011719 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 317936011720 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 317936011721 active site 317936011722 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 317936011723 protein binding site [polypeptide binding]; other site 317936011724 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 317936011725 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 317936011726 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 317936011727 minor groove reading motif; other site 317936011728 helix-hairpin-helix signature motif; other site 317936011729 substrate binding pocket [chemical binding]; other site 317936011730 active site 317936011731 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 317936011732 ribosomal protein S14; Region: rps14; CHL00074 317936011733 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 317936011734 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936011735 putative active site [active] 317936011736 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 317936011737 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 317936011738 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 317936011739 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936011740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936011741 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 317936011742 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936011743 Protein of unknown function (DUF433); Region: DUF433; pfam04255 317936011744 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 317936011745 putative active site [active] 317936011746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936011747 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 317936011748 NACHT domain; Region: NACHT; pfam05729 317936011749 HEAT repeats; Region: HEAT_2; pfam13646 317936011750 HEAT repeats; Region: HEAT_2; pfam13646 317936011751 HEAT repeats; Region: HEAT_2; pfam13646 317936011752 HEAT repeats; Region: HEAT_2; pfam13646 317936011753 HEAT repeats; Region: HEAT_2; pfam13646 317936011754 HEAT repeats; Region: HEAT_2; pfam13646 317936011755 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936011756 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936011757 Domain of unknown function DUF29; Region: DUF29; pfam01724 317936011758 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936011759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936011760 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936011761 pantothenate kinase; Reviewed; Region: PRK13331 317936011762 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936011763 Putative serine esterase (DUF676); Region: DUF676; pfam05057 317936011764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 317936011765 nudix motif; other site 317936011766 argininosuccinate lyase; Provisional; Region: PRK00855 317936011767 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 317936011768 active sites [active] 317936011769 tetramer interface [polypeptide binding]; other site 317936011770 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 317936011771 AIR carboxylase; Region: AIRC; smart01001 317936011772 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 317936011773 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 317936011774 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 317936011775 homotrimer interaction site [polypeptide binding]; other site 317936011776 zinc binding site [ion binding]; other site 317936011777 CDP-binding sites; other site 317936011778 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 317936011779 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 317936011780 proposed catalytic triad [active] 317936011781 active site nucleophile [active] 317936011782 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 317936011783 ATP-grasp domain; Region: ATP-grasp_4; cl17255 317936011784 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936011785 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936011786 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 317936011787 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011788 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011789 active site 317936011790 ATP binding site [chemical binding]; other site 317936011791 substrate binding site [chemical binding]; other site 317936011792 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936011793 substrate binding site [chemical binding]; other site 317936011794 activation loop (A-loop); other site 317936011795 activation loop (A-loop); other site 317936011796 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 317936011797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936011798 S-adenosylmethionine binding site [chemical binding]; other site 317936011799 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 317936011800 phosphatidate cytidylyltransferase; Region: PLN02953 317936011801 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 317936011802 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 317936011803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936011804 RNA binding surface [nucleotide binding]; other site 317936011805 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 317936011806 active site 317936011807 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 317936011808 Helix-turn-helix domain; Region: HTH_25; pfam13413 317936011809 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 317936011810 4-alpha-glucanotransferase; Provisional; Region: PRK14508 317936011811 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 317936011812 nudix motif; other site 317936011813 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936011814 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936011815 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936011816 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936011817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936011818 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 317936011819 homotrimer interaction site [polypeptide binding]; other site 317936011820 putative active site [active] 317936011821 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 317936011822 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 317936011823 trimer interface [polypeptide binding]; other site 317936011824 active site 317936011825 substrate binding site [chemical binding]; other site 317936011826 CoA binding site [chemical binding]; other site 317936011827 Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636 317936011828 putative active site [active] 317936011829 DNA repair protein RadA; Provisional; Region: PRK11823 317936011830 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 317936011831 Walker A motif/ATP binding site; other site 317936011832 ATP binding site [chemical binding]; other site 317936011833 Walker B motif; other site 317936011834 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 317936011835 Ycf27; Reviewed; Region: orf27; CHL00148 317936011836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936011837 active site 317936011838 phosphorylation site [posttranslational modification] 317936011839 intermolecular recognition site; other site 317936011840 dimerization interface [polypeptide binding]; other site 317936011841 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936011842 DNA binding site [nucleotide binding] 317936011843 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 317936011844 Protein of unknown function (DUF456); Region: DUF456; cl01069 317936011845 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011846 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011847 active site 317936011848 ATP binding site [chemical binding]; other site 317936011849 substrate binding site [chemical binding]; other site 317936011850 activation loop (A-loop); other site 317936011851 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936011852 structural tetrad; other site 317936011853 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 317936011854 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936011855 putative active site [active] 317936011856 HEAT repeats; Region: HEAT_2; pfam13646 317936011857 HEAT repeats; Region: HEAT_2; pfam13646 317936011858 HEAT repeats; Region: HEAT_2; pfam13646 317936011859 FOG: CBS domain [General function prediction only]; Region: COG0517 317936011860 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 317936011861 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 317936011862 active site 317936011863 8-oxo-dGMP binding site [chemical binding]; other site 317936011864 nudix motif; other site 317936011865 metal binding site [ion binding]; metal-binding site 317936011866 Protein of unknown function (DUF760); Region: DUF760; pfam05542 317936011867 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 317936011868 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936011869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936011870 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936011871 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936011872 DNA binding residues [nucleotide binding] 317936011873 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 317936011874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 317936011875 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 317936011876 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 317936011877 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 317936011878 ATP-grasp domain; Region: ATP-grasp_4; cl17255 317936011879 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 317936011880 IMP binding site; other site 317936011881 dimer interface [polypeptide binding]; other site 317936011882 interdomain contacts; other site 317936011883 partial ornithine binding site; other site 317936011884 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 317936011885 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 317936011886 dimerization interface [polypeptide binding]; other site 317936011887 DPS ferroxidase diiron center [ion binding]; other site 317936011888 ion pore; other site 317936011889 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 317936011890 dimer interface [polypeptide binding]; other site 317936011891 [2Fe-2S] cluster binding site [ion binding]; other site 317936011892 Protein of unknown function (DUF433); Region: DUF433; pfam04255 317936011893 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 317936011894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936011895 dimer interface [polypeptide binding]; other site 317936011896 conserved gate region; other site 317936011897 ABC-ATPase subunit interface; other site 317936011898 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 317936011899 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 317936011900 Walker A/P-loop; other site 317936011901 ATP binding site [chemical binding]; other site 317936011902 Q-loop/lid; other site 317936011903 ABC transporter signature motif; other site 317936011904 Walker B; other site 317936011905 D-loop; other site 317936011906 H-loop/switch region; other site 317936011907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 317936011908 substrate binding pocket [chemical binding]; other site 317936011909 membrane-bound complex binding site; other site 317936011910 hinge residues; other site 317936011911 Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085 317936011912 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011913 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011914 active site 317936011915 ATP binding site [chemical binding]; other site 317936011916 substrate binding site [chemical binding]; other site 317936011917 activation loop (A-loop); other site 317936011918 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936011919 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936011920 structural tetrad; other site 317936011921 WD40 repeats; Region: WD40; smart00320 317936011922 PemK-like protein; Region: PemK; pfam02452 317936011923 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936011924 putative active site [active] 317936011925 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 317936011926 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 317936011927 active site 317936011928 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936011929 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936011930 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936011931 ribosome maturation protein RimP; Reviewed; Region: PRK00092 317936011932 Sm and related proteins; Region: Sm_like; cl00259 317936011933 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 317936011934 putative oligomer interface [polypeptide binding]; other site 317936011935 putative RNA binding site [nucleotide binding]; other site 317936011936 NusA N-terminal domain; Region: NusA_N; pfam08529 317936011937 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 317936011938 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 317936011939 RNA binding site [nucleotide binding]; other site 317936011940 homodimer interface [polypeptide binding]; other site 317936011941 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 317936011942 G-X-X-G motif; other site 317936011943 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 317936011944 G-X-X-G motif; other site 317936011945 Protein of unknown function (DUF448); Region: DUF448; pfam04296 317936011946 putative RNA binding cleft [nucleotide binding]; other site 317936011947 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 317936011948 translation initiation factor IF-2; Region: IF-2; TIGR00487 317936011949 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 317936011950 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 317936011951 G1 box; other site 317936011952 putative GEF interaction site [polypeptide binding]; other site 317936011953 GTP/Mg2+ binding site [chemical binding]; other site 317936011954 Switch I region; other site 317936011955 G2 box; other site 317936011956 G3 box; other site 317936011957 Switch II region; other site 317936011958 G4 box; other site 317936011959 G5 box; other site 317936011960 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 317936011961 Translation-initiation factor 2; Region: IF-2; pfam11987 317936011962 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 317936011963 S-layer homology domain; Region: SLH; pfam00395 317936011964 Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240 317936011965 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 317936011966 active site 317936011967 catalytic triad [active] 317936011968 oxyanion hole [active] 317936011969 hypothetical protein; Provisional; Region: PRK06208 317936011970 intersubunit interface [polypeptide binding]; other site 317936011971 active site 317936011972 Zn2+ binding site [ion binding]; other site 317936011973 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 317936011974 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 317936011975 M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343 317936011976 Protein of unknown function (DUF3493); Region: DUF3493; pfam11998 317936011977 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 317936011978 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 317936011979 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 317936011980 S-layer homology domain; Region: SLH; pfam00395 317936011981 S-layer homology domain; Region: SLH; pfam00395 317936011982 adaptive-response sensory kinase; Validated; Region: PRK09303 317936011983 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 317936011984 tetramer interface [polypeptide binding]; other site 317936011985 dimer interface [polypeptide binding]; other site 317936011986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936011987 dimer interface [polypeptide binding]; other site 317936011988 phosphorylation site [posttranslational modification] 317936011989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936011990 ATP binding site [chemical binding]; other site 317936011991 Mg2+ binding site [ion binding]; other site 317936011992 G-X-G motif; other site 317936011993 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936011994 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936011995 active site 317936011996 ATP binding site [chemical binding]; other site 317936011997 substrate binding site [chemical binding]; other site 317936011998 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936011999 substrate binding site [chemical binding]; other site 317936012000 activation loop (A-loop); other site 317936012001 activation loop (A-loop); other site 317936012002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012003 binding surface 317936012004 TPR motif; other site 317936012005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012007 binding surface 317936012008 TPR motif; other site 317936012009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012010 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012011 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012012 binding surface 317936012013 TPR motif; other site 317936012014 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012015 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012018 binding surface 317936012019 TPR motif; other site 317936012020 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012021 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012023 binding surface 317936012024 TPR motif; other site 317936012025 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012026 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012027 CHAT domain; Region: CHAT; pfam12770 317936012028 GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450 317936012029 GIY-YIG motif/motif A; other site 317936012030 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 317936012031 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 317936012032 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 317936012033 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 317936012034 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 317936012035 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 317936012036 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 317936012037 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 317936012038 DNA binding site [nucleotide binding] 317936012039 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 317936012040 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 317936012041 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 317936012042 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 317936012043 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 317936012044 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 317936012045 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 317936012046 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 317936012047 RPB1 interaction site [polypeptide binding]; other site 317936012048 RPB10 interaction site [polypeptide binding]; other site 317936012049 RPB11 interaction site [polypeptide binding]; other site 317936012050 RPB3 interaction site [polypeptide binding]; other site 317936012051 RPB12 interaction site [polypeptide binding]; other site 317936012052 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 317936012053 active site 317936012054 ribosomal protein S20; Region: rps20; CHL00102 317936012055 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 317936012056 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 317936012057 NAD binding site [chemical binding]; other site 317936012058 dimerization interface [polypeptide binding]; other site 317936012059 product binding site; other site 317936012060 substrate binding site [chemical binding]; other site 317936012061 zinc binding site [ion binding]; other site 317936012062 catalytic residues [active] 317936012063 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 317936012064 Ligand Binding Site [chemical binding]; other site 317936012065 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 317936012066 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 317936012067 dimerization interface [polypeptide binding]; other site 317936012068 domain crossover interface; other site 317936012069 redox-dependent activation switch; other site 317936012070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936012071 dimer interface [polypeptide binding]; other site 317936012072 phosphorylation site [posttranslational modification] 317936012073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012074 ATP binding site [chemical binding]; other site 317936012075 Mg2+ binding site [ion binding]; other site 317936012076 G-X-G motif; other site 317936012077 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 317936012078 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 317936012079 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 317936012080 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 317936012081 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 317936012082 polyphosphate kinase; Provisional; Region: PRK05443 317936012083 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 317936012084 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 317936012085 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 317936012086 putative domain interface [polypeptide binding]; other site 317936012087 putative active site [active] 317936012088 catalytic site [active] 317936012089 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 317936012090 putative domain interface [polypeptide binding]; other site 317936012091 putative active site [active] 317936012092 catalytic site [active] 317936012093 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012095 active site 317936012096 phosphorylation site [posttranslational modification] 317936012097 intermolecular recognition site; other site 317936012098 dimerization interface [polypeptide binding]; other site 317936012099 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 317936012100 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 317936012101 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012103 active site 317936012104 phosphorylation site [posttranslational modification] 317936012105 intermolecular recognition site; other site 317936012106 dimerization interface [polypeptide binding]; other site 317936012107 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936012108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936012109 metal binding site [ion binding]; metal-binding site 317936012110 active site 317936012111 I-site; other site 317936012112 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 317936012113 L11 interface [polypeptide binding]; other site 317936012114 putative EF-Tu interaction site [polypeptide binding]; other site 317936012115 putative EF-G interaction site [polypeptide binding]; other site 317936012116 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 317936012117 23S rRNA interface [nucleotide binding]; other site 317936012118 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 317936012119 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 317936012120 mRNA/rRNA interface [nucleotide binding]; other site 317936012121 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 317936012122 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 317936012123 23S rRNA interface [nucleotide binding]; other site 317936012124 L7/L12 interface [polypeptide binding]; other site 317936012125 putative thiostrepton binding site; other site 317936012126 L25 interface [polypeptide binding]; other site 317936012127 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 317936012128 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 317936012129 putative homodimer interface [polypeptide binding]; other site 317936012130 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 317936012131 heterodimer interface [polypeptide binding]; other site 317936012132 homodimer interface [polypeptide binding]; other site 317936012133 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 317936012134 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 317936012135 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 317936012136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 317936012137 active site 317936012138 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 317936012139 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936012140 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936012141 CpeS-like protein; Region: CpeS; pfam09367 317936012142 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 317936012143 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 317936012144 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 317936012145 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 317936012146 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 317936012147 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 317936012148 dimer interface [polypeptide binding]; other site 317936012149 putative anticodon binding site; other site 317936012150 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 317936012151 motif 1; other site 317936012152 active site 317936012153 motif 2; other site 317936012154 motif 3; other site 317936012155 KTSC domain; Region: KTSC; pfam13619 317936012156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936012157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012158 active site 317936012159 phosphorylation site [posttranslational modification] 317936012160 intermolecular recognition site; other site 317936012161 dimerization interface [polypeptide binding]; other site 317936012162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936012163 DNA binding site [nucleotide binding] 317936012164 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 317936012165 AAA domain; Region: AAA_14; pfam13173 317936012166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 317936012167 active site residue [active] 317936012168 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 317936012169 catalytic site [active] 317936012170 putative active site [active] 317936012171 putative substrate binding site [chemical binding]; other site 317936012172 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 317936012173 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 317936012174 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936012175 putative active site [active] 317936012176 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 317936012177 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 317936012178 Domain of unknown function DUF29; Region: DUF29; pfam01724 317936012179 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 317936012180 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 317936012181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936012182 catalytic residue [active] 317936012183 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 317936012184 putative rRNA binding site [nucleotide binding]; other site 317936012185 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 317936012186 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 317936012187 Clp amino terminal domain; Region: Clp_N; pfam02861 317936012188 Clp amino terminal domain; Region: Clp_N; pfam02861 317936012189 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936012190 Walker A motif; other site 317936012191 ATP binding site [chemical binding]; other site 317936012192 Walker B motif; other site 317936012193 arginine finger; other site 317936012194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936012195 Walker A motif; other site 317936012196 ATP binding site [chemical binding]; other site 317936012197 Walker B motif; other site 317936012198 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 317936012199 Transposase IS200 like; Region: Y1_Tnp; pfam01797 317936012200 CHAT domain; Region: CHAT; pfam12770 317936012201 AAA ATPase domain; Region: AAA_16; pfam13191 317936012202 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012204 binding surface 317936012205 TPR motif; other site 317936012206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012209 binding surface 317936012210 TPR motif; other site 317936012211 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012213 binding surface 317936012214 TPR motif; other site 317936012215 TPR repeat; Region: TPR_11; pfam13414 317936012216 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936012217 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 317936012218 2TM domain; Region: 2TM; pfam13239 317936012219 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012220 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012221 active site 317936012222 phosphorylation site [posttranslational modification] 317936012223 intermolecular recognition site; other site 317936012224 dimerization interface [polypeptide binding]; other site 317936012225 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 317936012226 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 317936012227 trimer interface [polypeptide binding]; other site 317936012228 dimer interface [polypeptide binding]; other site 317936012229 putative active site [active] 317936012230 sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485 317936012231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 317936012232 cyclase homology domain; Region: CHD; cd07302 317936012233 nucleotidyl binding site; other site 317936012234 metal binding site [ion binding]; metal-binding site 317936012235 dimer interface [polypeptide binding]; other site 317936012236 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936012237 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936012238 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936012239 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936012240 structural tetrad; other site 317936012241 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936012242 structural tetrad; other site 317936012243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936012244 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936012245 putative substrate translocation pore; other site 317936012246 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936012247 putative active site [active] 317936012248 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 317936012249 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 317936012250 Putative Catalytic site; other site 317936012251 DXD motif; other site 317936012252 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 317936012253 NlpC/P60 family; Region: NLPC_P60; pfam00877 317936012254 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 317936012255 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 317936012256 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 317936012257 putative ligand binding site [chemical binding]; other site 317936012258 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 317936012259 active site lid residues [active] 317936012260 substrate binding pocket [chemical binding]; other site 317936012261 catalytic residues [active] 317936012262 substrate-Mg2+ binding site; other site 317936012263 aspartate-rich region 1; other site 317936012264 aspartate-rich region 2; other site 317936012265 phytoene desaturase; Region: phytoene_desat; TIGR02731 317936012266 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936012267 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 317936012268 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 317936012269 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 317936012270 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 317936012271 B12 binding site [chemical binding]; other site 317936012272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 317936012273 FeS/SAM binding site; other site 317936012274 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 317936012275 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 317936012276 putative hydrophobic ligand binding site [chemical binding]; other site 317936012277 Predicted membrane protein [Function unknown]; Region: COG1950 317936012278 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 317936012279 cytochrome c6; Provisional; Region: PRK13697 317936012280 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 317936012281 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936012282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 317936012283 active site 317936012284 metal binding site [ion binding]; metal-binding site 317936012285 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 317936012286 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 317936012287 active site 317936012288 NTP binding site [chemical binding]; other site 317936012289 metal binding triad [ion binding]; metal-binding site 317936012290 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 317936012291 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 317936012292 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 317936012293 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 317936012294 Glycoprotease family; Region: Peptidase_M22; pfam00814 317936012295 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 317936012296 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 317936012297 NodB motif; other site 317936012298 active site 317936012299 catalytic site [active] 317936012300 metal binding site [ion binding]; metal-binding site 317936012301 Methyltransferase domain; Region: Methyltransf_31; pfam13847 317936012302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936012303 S-adenosylmethionine binding site [chemical binding]; other site 317936012304 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 317936012305 intracellular protease, PfpI family; Region: PfpI; TIGR01382 317936012306 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 317936012307 proposed catalytic triad [active] 317936012308 conserved cys residue [active] 317936012309 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 317936012310 dinuclear metal binding motif [ion binding]; other site 317936012311 Predicted integral membrane protein [Function unknown]; Region: COG5637 317936012312 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 317936012313 putative hydrophobic ligand binding site [chemical binding]; other site 317936012314 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 317936012315 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 317936012316 NAD binding site [chemical binding]; other site 317936012317 catalytic Zn binding site [ion binding]; other site 317936012318 structural Zn binding site [ion binding]; other site 317936012319 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 317936012320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 317936012321 NAD binding site [chemical binding]; other site 317936012322 catalytic Zn binding site [ion binding]; other site 317936012323 structural Zn binding site [ion binding]; other site 317936012324 Cupin domain; Region: Cupin_2; pfam07883 317936012325 Caspase domain; Region: Peptidase_C14; pfam00656 317936012326 Clp amino terminal domain; Region: Clp_N; pfam02861 317936012327 Clp amino terminal domain; Region: Clp_N; pfam02861 317936012328 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 317936012329 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 317936012330 active site 317936012331 substrate binding site [chemical binding]; other site 317936012332 metal binding site [ion binding]; metal-binding site 317936012333 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 317936012334 heme binding pocket [chemical binding]; other site 317936012335 heme ligand [chemical binding]; other site 317936012336 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 317936012337 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 317936012338 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 317936012339 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 317936012340 Predicted methyltransferase [General function prediction only]; Region: COG4798 317936012341 Methyltransferase domain; Region: Methyltransf_23; pfam13489 317936012342 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 317936012343 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 317936012344 dimer interface [polypeptide binding]; other site 317936012345 ssDNA binding site [nucleotide binding]; other site 317936012346 tetramer (dimer of dimers) interface [polypeptide binding]; other site 317936012347 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 317936012348 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 317936012349 Walker A/P-loop; other site 317936012350 ATP binding site [chemical binding]; other site 317936012351 Q-loop/lid; other site 317936012352 ABC transporter signature motif; other site 317936012353 Walker B; other site 317936012354 D-loop; other site 317936012355 H-loop/switch region; other site 317936012356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 317936012357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 317936012358 Walker A/P-loop; other site 317936012359 ATP binding site [chemical binding]; other site 317936012360 Q-loop/lid; other site 317936012361 ABC transporter signature motif; other site 317936012362 Walker B; other site 317936012363 D-loop; other site 317936012364 H-loop/switch region; other site 317936012365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 317936012366 Predicted metal-binding protein [General function prediction only]; Region: COG3019 317936012367 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 317936012368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936012369 Walker A motif; other site 317936012370 ATP binding site [chemical binding]; other site 317936012371 Walker B motif; other site 317936012372 arginine finger; other site 317936012373 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 317936012374 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 317936012375 tetramer interface [polypeptide binding]; other site 317936012376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936012377 catalytic residue [active] 317936012378 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 317936012379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 317936012380 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 317936012381 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 317936012382 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 317936012383 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 317936012384 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 317936012385 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 317936012386 substrate binding site [chemical binding]; other site 317936012387 hexamer interface [polypeptide binding]; other site 317936012388 metal binding site [ion binding]; metal-binding site 317936012389 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 317936012390 putative catalytic residues [active] 317936012391 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 317936012392 putative active site [active] 317936012393 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 317936012394 serpin-like protein; Provisional; Region: PHA02660 317936012395 reactive center loop; other site 317936012396 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 317936012397 Domain of unknown function DUF20; Region: UPF0118; pfam01594 317936012398 Transcriptional regulator [Transcription]; Region: LytR; COG1316 317936012399 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 317936012400 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 317936012401 dimerization interface [polypeptide binding]; other site 317936012402 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936012403 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936012404 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936012405 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936012406 PAS domain S-box; Region: sensory_box; TIGR00229 317936012407 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012408 putative active site [active] 317936012409 heme pocket [chemical binding]; other site 317936012410 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 317936012411 cyclase homology domain; Region: CHD; cd07302 317936012412 nucleotidyl binding site; other site 317936012413 metal binding site [ion binding]; metal-binding site 317936012414 dimer interface [polypeptide binding]; other site 317936012415 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 317936012416 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 317936012417 Predicted membrane protein [Function unknown]; Region: COG2119 317936012418 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 317936012419 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 317936012420 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 317936012421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936012422 non-specific DNA binding site [nucleotide binding]; other site 317936012423 salt bridge; other site 317936012424 sequence-specific DNA binding site [nucleotide binding]; other site 317936012425 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 317936012426 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 317936012427 hypothetical protein; Provisional; Region: PRK13686 317936012428 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 317936012429 DHH family; Region: DHH; pfam01368 317936012430 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 317936012431 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 317936012432 classical (c) SDRs; Region: SDR_c; cd05233 317936012433 NAD(P) binding site [chemical binding]; other site 317936012434 active site 317936012435 PGAP1-like protein; Region: PGAP1; pfam07819 317936012436 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 317936012437 Part of AAA domain; Region: AAA_19; pfam13245 317936012438 Family description; Region: UvrD_C_2; pfam13538 317936012439 glycogen synthase; Provisional; Region: glgA; PRK00654 317936012440 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 317936012441 ADP-binding pocket [chemical binding]; other site 317936012442 homodimer interface [polypeptide binding]; other site 317936012443 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012444 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012445 active site 317936012446 phosphorylation site [posttranslational modification] 317936012447 intermolecular recognition site; other site 317936012448 dimerization interface [polypeptide binding]; other site 317936012449 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936012450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936012451 metal binding site [ion binding]; metal-binding site 317936012452 active site 317936012453 I-site; other site 317936012454 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 317936012455 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 317936012456 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 317936012457 CoA-binding site [chemical binding]; other site 317936012458 ATP-binding [chemical binding]; other site 317936012459 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 317936012460 active site 317936012461 SAM binding site [chemical binding]; other site 317936012462 homodimer interface [polypeptide binding]; other site 317936012463 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 317936012464 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 317936012465 active site 317936012466 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936012467 putative active site [active] 317936012468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012469 binding surface 317936012470 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936012471 TPR motif; other site 317936012472 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936012473 tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887 317936012474 UbiA prenyltransferase family; Region: UbiA; pfam01040 317936012475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 317936012476 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936012477 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 317936012478 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 317936012479 active site 317936012480 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936012481 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936012482 active site 317936012483 catalytic tetrad [active] 317936012484 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 317936012485 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 317936012486 dimerization interface [polypeptide binding]; other site 317936012487 DPS ferroxidase diiron center [ion binding]; other site 317936012488 ion pore; other site 317936012489 Pirin-related protein [General function prediction only]; Region: COG1741 317936012490 Pirin; Region: Pirin; pfam02678 317936012491 Pirin-related protein [General function prediction only]; Region: COG1741 317936012492 Pirin; Region: Pirin; pfam02678 317936012493 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 317936012494 Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967 317936012495 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 317936012496 active site 317936012497 catalytic site [active] 317936012498 substrate binding site [chemical binding]; other site 317936012499 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936012500 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936012501 metal binding site [ion binding]; metal-binding site 317936012502 active site 317936012503 I-site; other site 317936012504 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 317936012505 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 317936012506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 317936012507 Walker A motif; other site 317936012508 ATP binding site [chemical binding]; other site 317936012509 Walker B motif; other site 317936012510 HEAT repeats; Region: HEAT_2; pfam13646 317936012511 HEAT repeats; Region: HEAT_2; pfam13646 317936012512 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 317936012513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936012514 RNA binding surface [nucleotide binding]; other site 317936012515 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 317936012516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 317936012517 ABC-ATPase subunit interface; other site 317936012518 dimer interface [polypeptide binding]; other site 317936012519 putative PBP binding regions; other site 317936012520 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 317936012521 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 317936012522 ABC-ATPase subunit interface; other site 317936012523 dimer interface [polypeptide binding]; other site 317936012524 putative PBP binding regions; other site 317936012525 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 317936012526 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 317936012527 Walker A/P-loop; other site 317936012528 ATP binding site [chemical binding]; other site 317936012529 Q-loop/lid; other site 317936012530 ABC transporter signature motif; other site 317936012531 Walker B; other site 317936012532 D-loop; other site 317936012533 H-loop/switch region; other site 317936012534 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 317936012535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936012536 AMIN domain; Region: AMIN; pfam11741 317936012537 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 317936012538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936012539 N-terminal plug; other site 317936012540 ligand-binding site [chemical binding]; other site 317936012541 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 317936012542 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 317936012543 siderophore binding site; other site 317936012544 Predicted membrane protein [Function unknown]; Region: COG2510 317936012545 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 317936012546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936012547 AMIN domain; Region: AMIN; pfam11741 317936012548 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 317936012549 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936012550 N-terminal plug; other site 317936012551 ligand-binding site [chemical binding]; other site 317936012552 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 317936012553 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 317936012554 siderophore binding site; other site 317936012555 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 317936012556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936012557 AMIN domain; Region: AMIN; pfam11741 317936012558 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 317936012559 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936012560 N-terminal plug; other site 317936012561 ligand-binding site [chemical binding]; other site 317936012562 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 317936012563 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 317936012564 siderophore binding site; other site 317936012565 Predicted metal-binding protein [Function unknown]; Region: COG5469 317936012566 C factor cell-cell signaling protein; Provisional; Region: PRK09009 317936012567 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 317936012568 NADP binding site [chemical binding]; other site 317936012569 homodimer interface [polypeptide binding]; other site 317936012570 active site 317936012571 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 317936012572 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 317936012573 active site 317936012574 FMN binding site [chemical binding]; other site 317936012575 substrate binding site [chemical binding]; other site 317936012576 homotetramer interface [polypeptide binding]; other site 317936012577 catalytic residue [active] 317936012578 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012580 active site 317936012581 phosphorylation site [posttranslational modification] 317936012582 intermolecular recognition site; other site 317936012583 dimerization interface [polypeptide binding]; other site 317936012584 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936012585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012586 ATP binding site [chemical binding]; other site 317936012587 Mg2+ binding site [ion binding]; other site 317936012588 G-X-G motif; other site 317936012589 MASE1; Region: MASE1; pfam05231 317936012590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936012591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936012592 dimer interface [polypeptide binding]; other site 317936012593 phosphorylation site [posttranslational modification] 317936012594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012595 ATP binding site [chemical binding]; other site 317936012596 Mg2+ binding site [ion binding]; other site 317936012597 G-X-G motif; other site 317936012598 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936012599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012600 active site 317936012601 phosphorylation site [posttranslational modification] 317936012602 intermolecular recognition site; other site 317936012603 dimerization interface [polypeptide binding]; other site 317936012604 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 317936012605 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 317936012606 Cysteine-rich domain; Region: CCG; pfam02754 317936012607 Cysteine-rich domain; Region: CCG; pfam02754 317936012608 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 317936012609 FAD binding domain; Region: FAD_binding_4; pfam01565 317936012610 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 317936012611 FAD binding domain; Region: FAD_binding_4; pfam01565 317936012612 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 317936012613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936012614 binding surface 317936012615 TPR motif; other site 317936012616 TPR repeat; Region: TPR_11; pfam13414 317936012617 Uncharacterized conserved protein [Function unknown]; Region: COG5609 317936012618 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012620 active site 317936012621 phosphorylation site [posttranslational modification] 317936012622 intermolecular recognition site; other site 317936012623 dimerization interface [polypeptide binding]; other site 317936012624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 317936012625 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 317936012626 TM-ABC transporter signature motif; other site 317936012627 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 317936012628 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 317936012629 TM-ABC transporter signature motif; other site 317936012630 Protein of unknown function DUF91; Region: DUF91; cl00709 317936012631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 317936012632 AAA domain; Region: AAA_23; pfam13476 317936012633 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 317936012634 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 317936012635 Walker A/P-loop; other site 317936012636 ATP binding site [chemical binding]; other site 317936012637 Q-loop/lid; other site 317936012638 ABC transporter signature motif; other site 317936012639 Walker B; other site 317936012640 D-loop; other site 317936012641 H-loop/switch region; other site 317936012642 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 317936012643 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 317936012644 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 317936012645 putative ligand binding site [chemical binding]; other site 317936012646 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 317936012647 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936012648 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 317936012649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936012650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936012651 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 317936012652 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 317936012653 trmE is a tRNA modification GTPase; Region: trmE; cd04164 317936012654 G1 box; other site 317936012655 GTP/Mg2+ binding site [chemical binding]; other site 317936012656 Switch I region; other site 317936012657 G2 box; other site 317936012658 Switch II region; other site 317936012659 G3 box; other site 317936012660 G4 box; other site 317936012661 G5 box; other site 317936012662 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 317936012663 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 317936012664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936012665 S-adenosylmethionine binding site [chemical binding]; other site 317936012666 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 317936012667 HD domain; Region: HD_4; pfam13328 317936012668 WYL domain; Region: WYL; cl14852 317936012669 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 317936012670 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 317936012671 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 317936012672 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 317936012673 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 317936012674 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 317936012675 AAA domain; Region: AAA_23; pfam13476 317936012676 AAA domain; Region: AAA_21; pfam13304 317936012677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936012678 ABC transporter signature motif; other site 317936012679 Walker B; other site 317936012680 D-loop; other site 317936012681 H-loop/switch region; other site 317936012682 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 317936012683 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl01634 317936012684 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 317936012685 Uncharacterized conserved protein [Function unknown]; Region: COG3379 317936012686 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936012687 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936012688 GAF domain; Region: GAF; cl17456 317936012689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 317936012690 Histidine kinase; Region: HisKA_3; pfam07730 317936012691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012692 ATP binding site [chemical binding]; other site 317936012693 Mg2+ binding site [ion binding]; other site 317936012694 G-X-G motif; other site 317936012695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936012696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012697 active site 317936012698 phosphorylation site [posttranslational modification] 317936012699 intermolecular recognition site; other site 317936012700 dimerization interface [polypeptide binding]; other site 317936012701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936012702 DNA binding residues [nucleotide binding] 317936012703 dimerization interface [polypeptide binding]; other site 317936012704 High-affinity nickel-transport protein; Region: NicO; cl00964 317936012705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 317936012706 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 317936012707 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 317936012708 FMN binding site [chemical binding]; other site 317936012709 active site 317936012710 substrate binding site [chemical binding]; other site 317936012711 catalytic residue [active] 317936012712 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 317936012713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936012714 putative substrate translocation pore; other site 317936012715 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 317936012716 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 317936012717 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936012718 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936012719 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 317936012720 Fasciclin domain; Region: Fasciclin; pfam02469 317936012721 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 317936012722 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936012723 putative active site [active] 317936012724 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936012725 oligomeric interface; other site 317936012726 putative active site [active] 317936012727 homodimer interface [polypeptide binding]; other site 317936012728 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 317936012729 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 317936012730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936012731 ATP binding site [chemical binding]; other site 317936012732 putative Mg++ binding site [ion binding]; other site 317936012733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936012734 nucleotide binding region [chemical binding]; other site 317936012735 ATP-binding site [chemical binding]; other site 317936012736 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 317936012737 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 317936012738 Domain of unknown function DUF21; Region: DUF21; pfam01595 317936012739 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 317936012740 Transporter associated domain; Region: CorC_HlyC; smart01091 317936012741 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936012742 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936012743 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 317936012744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936012745 active site 317936012746 catalytic tetrad [active] 317936012747 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 317936012748 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936012749 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 317936012750 protein binding site [polypeptide binding]; other site 317936012751 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 317936012752 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 317936012753 putative homodimer interface [polypeptide binding]; other site 317936012754 putative homotetramer interface [polypeptide binding]; other site 317936012755 putative metal binding site [ion binding]; other site 317936012756 putative homodimer-homodimer interface [polypeptide binding]; other site 317936012757 putative allosteric switch controlling residues; other site 317936012758 Domain of unknown function (DUF4327); Region: DUF4327; pfam14217 317936012759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 317936012760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 317936012761 DNA binding site [nucleotide binding] 317936012762 domain linker motif; other site 317936012763 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 317936012764 dimerization interface [polypeptide binding]; other site 317936012765 ligand binding site [chemical binding]; other site 317936012766 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 317936012767 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 317936012768 putative ligand binding site [chemical binding]; other site 317936012769 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 317936012770 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 317936012771 Walker A/P-loop; other site 317936012772 ATP binding site [chemical binding]; other site 317936012773 Q-loop/lid; other site 317936012774 ABC transporter signature motif; other site 317936012775 Walker B; other site 317936012776 D-loop; other site 317936012777 H-loop/switch region; other site 317936012778 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 317936012779 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 317936012780 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 317936012781 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 317936012782 TM-ABC transporter signature motif; other site 317936012783 Protein kinase domain; Region: Pkinase; pfam00069 317936012784 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936012785 active site 317936012786 ATP binding site [chemical binding]; other site 317936012787 substrate binding site [chemical binding]; other site 317936012788 activation loop (A-loop); other site 317936012789 AAA ATPase domain; Region: AAA_16; pfam13191 317936012790 Predicted ATPase [General function prediction only]; Region: COG3899 317936012791 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936012792 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936012793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012794 putative active site [active] 317936012795 heme pocket [chemical binding]; other site 317936012796 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936012797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012798 ATP binding site [chemical binding]; other site 317936012799 Mg2+ binding site [ion binding]; other site 317936012800 G-X-G motif; other site 317936012801 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 317936012802 nucleotide binding site/active site [active] 317936012803 HIT family signature motif; other site 317936012804 catalytic residue [active] 317936012805 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 317936012806 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 317936012807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936012808 Walker A motif; other site 317936012809 ATP binding site [chemical binding]; other site 317936012810 Walker B motif; other site 317936012811 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 317936012812 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 317936012813 adenylosuccinate lyase; Provisional; Region: PRK07380 317936012814 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 317936012815 tetramer interface [polypeptide binding]; other site 317936012816 active site 317936012817 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 317936012818 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 317936012819 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 317936012820 active site 317936012821 SAM binding site [chemical binding]; other site 317936012822 homodimer interface [polypeptide binding]; other site 317936012823 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 317936012824 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936012825 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936012826 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936012827 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 317936012828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936012829 FeS/SAM binding site; other site 317936012830 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936012831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012832 active site 317936012833 phosphorylation site [posttranslational modification] 317936012834 intermolecular recognition site; other site 317936012835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012836 PAS fold; Region: PAS_3; pfam08447 317936012837 putative active site [active] 317936012838 heme pocket [chemical binding]; other site 317936012839 PAS fold; Region: PAS_3; pfam08447 317936012840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012841 putative active site [active] 317936012842 heme pocket [chemical binding]; other site 317936012843 PAS domain S-box; Region: sensory_box; TIGR00229 317936012844 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012845 putative active site [active] 317936012846 heme pocket [chemical binding]; other site 317936012847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936012848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936012849 dimer interface [polypeptide binding]; other site 317936012850 phosphorylation site [posttranslational modification] 317936012851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012852 ATP binding site [chemical binding]; other site 317936012853 Mg2+ binding site [ion binding]; other site 317936012854 G-X-G motif; other site 317936012855 Response regulator receiver domain; Region: Response_reg; pfam00072 317936012856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012857 active site 317936012858 phosphorylation site [posttranslational modification] 317936012859 intermolecular recognition site; other site 317936012860 dimerization interface [polypeptide binding]; other site 317936012861 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 317936012862 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 317936012863 RNA polymerase sigma factor; Validated; Region: PRK05949 317936012864 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936012865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936012866 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936012867 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936012868 DNA binding residues [nucleotide binding] 317936012869 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 317936012870 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 317936012871 acyl-activating enzyme (AAE) consensus motif; other site 317936012872 active site 317936012873 AMP binding site [chemical binding]; other site 317936012874 CoA binding site [chemical binding]; other site 317936012875 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 317936012876 EF-hand domain pair; Region: EF_hand_5; pfam13499 317936012877 Ca2+ binding site [ion binding]; other site 317936012878 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 317936012879 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936012880 C-terminal domain interface [polypeptide binding]; other site 317936012881 GSH binding site (G-site) [chemical binding]; other site 317936012882 dimer interface [polypeptide binding]; other site 317936012883 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 317936012884 N-terminal domain interface [polypeptide binding]; other site 317936012885 dimer interface [polypeptide binding]; other site 317936012886 substrate binding pocket (H-site) [chemical binding]; other site 317936012887 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 317936012888 starch-binding site 2 [chemical binding]; other site 317936012889 starch-binding site 1 [chemical binding]; other site 317936012890 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 317936012891 active site 317936012892 catalytic triad [active] 317936012893 oxyanion hole [active] 317936012894 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 317936012895 Uncharacterized conserved protein [Function unknown]; Region: COG1359 317936012896 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 317936012897 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 317936012898 Cytochrome c; Region: Cytochrom_C; pfam00034 317936012899 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 317936012900 active site 317936012901 FMN binding site [chemical binding]; other site 317936012902 substrate binding site [chemical binding]; other site 317936012903 putative catalytic residue [active] 317936012904 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 317936012905 phosphate binding site [ion binding]; other site 317936012906 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 317936012907 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936012908 putative active site [active] 317936012909 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 317936012910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296 317936012911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936012912 dimer interface [polypeptide binding]; other site 317936012913 phosphorylation site [posttranslational modification] 317936012914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012915 ATP binding site [chemical binding]; other site 317936012916 Mg2+ binding site [ion binding]; other site 317936012917 G-X-G motif; other site 317936012918 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 317936012919 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 317936012920 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 317936012921 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936012922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012923 active site 317936012924 phosphorylation site [posttranslational modification] 317936012925 intermolecular recognition site; other site 317936012926 dimerization interface [polypeptide binding]; other site 317936012927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012928 PAS domain; Region: PAS_9; pfam13426 317936012929 putative active site [active] 317936012930 heme pocket [chemical binding]; other site 317936012931 PAS fold; Region: PAS; pfam00989 317936012932 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936012933 putative active site [active] 317936012934 heme pocket [chemical binding]; other site 317936012935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936012936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936012937 dimer interface [polypeptide binding]; other site 317936012938 phosphorylation site [posttranslational modification] 317936012939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012940 ATP binding site [chemical binding]; other site 317936012941 Mg2+ binding site [ion binding]; other site 317936012942 G-X-G motif; other site 317936012943 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936012944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936012945 active site 317936012946 phosphorylation site [posttranslational modification] 317936012947 intermolecular recognition site; other site 317936012948 dimerization interface [polypeptide binding]; other site 317936012949 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 317936012950 catalytic motif [active] 317936012951 Catalytic residue [active] 317936012952 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 317936012953 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 317936012954 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 317936012955 active site 317936012956 NTP binding site [chemical binding]; other site 317936012957 metal binding triad [ion binding]; metal-binding site 317936012958 antibiotic binding site [chemical binding]; other site 317936012959 Uncharacterized conserved protein [Function unknown]; Region: COG2361 317936012960 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936012961 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645 317936012962 ATP-NAD kinase; Region: NAD_kinase; pfam01513 317936012963 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 317936012964 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 317936012965 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 317936012966 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 317936012967 4Fe-4S binding domain; Region: Fer4; pfam00037 317936012968 NADH dehydrogenase; Region: NADHdh; cl00469 317936012969 citrate synthase; Provisional; Region: PRK14036 317936012970 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112 317936012971 dimer interface [polypeptide binding]; other site 317936012972 active site 317936012973 citrylCoA binding site [chemical binding]; other site 317936012974 oxalacetate/citrate binding site [chemical binding]; other site 317936012975 coenzyme A binding site [chemical binding]; other site 317936012976 catalytic triad [active] 317936012977 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936012978 catalytic core [active] 317936012979 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 317936012980 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 317936012981 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 317936012982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936012983 ATP binding site [chemical binding]; other site 317936012984 putative Mg++ binding site [ion binding]; other site 317936012985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936012986 nucleotide binding region [chemical binding]; other site 317936012987 ATP-binding site [chemical binding]; other site 317936012988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936012989 ATP binding site [chemical binding]; other site 317936012990 Mg2+ binding site [ion binding]; other site 317936012991 G-X-G motif; other site 317936012992 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 317936012993 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 317936012994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936012995 catalytic residue [active] 317936012996 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 317936012997 DHH family; Region: DHH; pfam01368 317936012998 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 317936012999 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 317936013000 active site 317936013001 alanine racemase; Reviewed; Region: alr; PRK00053 317936013002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 317936013003 active site 317936013004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 317936013005 dimer interface [polypeptide binding]; other site 317936013006 substrate binding site [chemical binding]; other site 317936013007 catalytic residues [active] 317936013008 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 317936013009 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 317936013010 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936013011 ATP binding site [chemical binding]; other site 317936013012 putative Mg++ binding site [ion binding]; other site 317936013013 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 317936013014 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936013015 oligomeric interface; other site 317936013016 putative active site [active] 317936013017 homodimer interface [polypeptide binding]; other site 317936013018 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936013019 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936013020 Domain of unknown function DUF29; Region: DUF29; pfam01724 317936013021 XisI protein; Region: XisI; pfam08869 317936013022 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 317936013023 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 317936013024 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 317936013025 HsdM N-terminal domain; Region: HsdM_N; pfam12161 317936013026 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 317936013027 Methyltransferase domain; Region: Methyltransf_26; pfam13659 317936013028 Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098 317936013029 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 317936013030 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 317936013031 phosphopeptide binding site; other site 317936013032 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013033 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936013034 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013035 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 317936013036 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 317936013037 CHAT domain; Region: CHAT; cl17868 317936013038 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936013039 CHASE2 domain; Region: CHASE2; pfam05226 317936013040 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936013041 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 317936013042 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 317936013043 P-loop, Walker A motif; other site 317936013044 Base recognition motif; other site 317936013045 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 317936013046 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 317936013047 amino acid transporter; Region: 2A0306; TIGR00909 317936013048 S-layer homology domain; Region: SLH; pfam00395 317936013049 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936013050 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936013051 putative active site [active] 317936013052 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 317936013053 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936013054 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936013055 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936013056 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 317936013057 Predicted transcriptional regulators [Transcription]; Region: COG1695 317936013058 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 317936013059 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 317936013060 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 317936013061 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936013062 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013063 dimer interface [polypeptide binding]; other site 317936013064 phosphorylation site [posttranslational modification] 317936013065 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013066 ATP binding site [chemical binding]; other site 317936013067 Mg2+ binding site [ion binding]; other site 317936013068 G-X-G motif; other site 317936013069 S-layer homology domain; Region: SLH; pfam00395 317936013070 S-layer homology domain; Region: SLH; pfam00395 317936013071 S-layer homology domain; Region: SLH; pfam00395 317936013072 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936013073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936013074 S-adenosylmethionine binding site [chemical binding]; other site 317936013075 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 317936013076 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 317936013077 Walker A/P-loop; other site 317936013078 ATP binding site [chemical binding]; other site 317936013079 Q-loop/lid; other site 317936013080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013081 ABC transporter signature motif; other site 317936013082 Walker B; other site 317936013083 D-loop; other site 317936013084 H-loop/switch region; other site 317936013085 putative phosphoketolase; Provisional; Region: PRK05261 317936013086 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 317936013087 TPP-binding site; other site 317936013088 XFP C-terminal domain; Region: XFP_C; pfam09363 317936013089 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 317936013090 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 317936013091 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 317936013092 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 317936013093 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 317936013094 domain interfaces; other site 317936013095 active site 317936013096 transaldolase-like protein; Provisional; Region: PTZ00411 317936013097 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 317936013098 active site 317936013099 dimer interface [polypeptide binding]; other site 317936013100 catalytic residue [active] 317936013101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013102 Walker A/P-loop; other site 317936013103 ATP binding site [chemical binding]; other site 317936013104 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 317936013105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 317936013106 Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443 317936013107 active site 317936013108 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 317936013109 propionate/acetate kinase; Provisional; Region: PRK12379 317936013110 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 317936013111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 317936013112 SPFH domain / Band 7 family; Region: Band_7; pfam01145 317936013113 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936013114 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936013115 structural tetrad; other site 317936013116 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936013117 structural tetrad; other site 317936013118 WD domain, G-beta repeat; Region: WD40; pfam00400 317936013119 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 317936013120 putative active site [active] 317936013121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 317936013122 Uncharacterized conserved protein [Function unknown]; Region: COG2442 317936013123 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936013124 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936013125 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 317936013126 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 317936013127 gamma subunit interface [polypeptide binding]; other site 317936013128 epsilon subunit interface [polypeptide binding]; other site 317936013129 LBP interface [polypeptide binding]; other site 317936013130 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 317936013131 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 317936013132 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 317936013133 alpha subunit interaction interface [polypeptide binding]; other site 317936013134 Walker A motif; other site 317936013135 ATP binding site [chemical binding]; other site 317936013136 Walker B motif; other site 317936013137 inhibitor binding site; inhibition site 317936013138 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 317936013139 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 317936013140 Peptidase family M50; Region: Peptidase_M50; pfam02163 317936013141 active site 317936013142 putative substrate binding region [chemical binding]; other site 317936013143 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936013144 carboxyl-terminal processing protease; Provisional; Region: PLN00049 317936013145 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 317936013146 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 317936013147 protein binding site [polypeptide binding]; other site 317936013148 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 317936013149 Catalytic dyad [active] 317936013150 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 317936013151 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 317936013152 Qi binding site; other site 317936013153 intrachain domain interface; other site 317936013154 interchain domain interface [polypeptide binding]; other site 317936013155 heme bH binding site [chemical binding]; other site 317936013156 heme bL binding site [chemical binding]; other site 317936013157 Qo binding site; other site 317936013158 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 317936013159 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 317936013160 interchain domain interface [polypeptide binding]; other site 317936013161 intrachain domain interface; other site 317936013162 Qi binding site; other site 317936013163 Qo binding site; other site 317936013164 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 317936013165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013166 ATP binding site [chemical binding]; other site 317936013167 Mg2+ binding site [ion binding]; other site 317936013168 G-X-G motif; other site 317936013169 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936013170 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013171 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 317936013172 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 317936013173 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 317936013174 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 317936013175 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 317936013176 active site 317936013177 HIGH motif; other site 317936013178 dimer interface [polypeptide binding]; other site 317936013179 KMSKS motif; other site 317936013180 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 317936013181 FAD binding site [chemical binding]; other site 317936013182 Protein of unknown function DUF262; Region: DUF262; pfam03235 317936013183 Uncharacterized conserved protein [Function unknown]; Region: COG4938 317936013184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013185 Walker A/P-loop; other site 317936013186 ATP binding site [chemical binding]; other site 317936013187 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 317936013188 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936013189 putative active site [active] 317936013190 Putative restriction endonuclease; Region: Uma2; pfam05685 317936013191 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 317936013192 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 317936013193 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 317936013194 catalytic residue [active] 317936013195 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 317936013196 PLD-like domain; Region: PLDc_2; pfam13091 317936013197 putative active site [active] 317936013198 catalytic site [active] 317936013199 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 317936013200 PLD-like domain; Region: PLDc_2; pfam13091 317936013201 putative active site [active] 317936013202 catalytic site [active] 317936013203 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 317936013204 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 317936013205 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 317936013206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 317936013207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936013208 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 317936013209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936013210 motif II; other site 317936013211 XisH protein; Region: XisH; pfam08814 317936013212 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 317936013213 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 317936013214 dimer interface [polypeptide binding]; other site 317936013215 ADP-ribose binding site [chemical binding]; other site 317936013216 active site 317936013217 nudix motif; other site 317936013218 metal binding site [ion binding]; metal-binding site 317936013219 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 317936013220 catalytic center binding site [active] 317936013221 ATP binding site [chemical binding]; other site 317936013222 Transglycosylase; Region: Transgly; pfam00912 317936013223 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 317936013224 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 317936013225 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 317936013226 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 317936013227 putative switch regulator; other site 317936013228 non-specific DNA interactions [nucleotide binding]; other site 317936013229 DNA binding site [nucleotide binding] 317936013230 sequence specific DNA binding site [nucleotide binding]; other site 317936013231 putative cAMP binding site [chemical binding]; other site 317936013232 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 317936013233 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 317936013234 putative NAD(P) binding site [chemical binding]; other site 317936013235 homodimer interface [polypeptide binding]; other site 317936013236 homotetramer interface [polypeptide binding]; other site 317936013237 active site 317936013238 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 317936013239 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 317936013240 active site 317936013241 homodimer interface [polypeptide binding]; other site 317936013242 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 317936013243 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 317936013244 Protein of unknown function, DUF608; Region: DUF608; pfam04685 317936013245 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 317936013246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936013247 dimer interface [polypeptide binding]; other site 317936013248 conserved gate region; other site 317936013249 putative PBP binding loops; other site 317936013250 ABC-ATPase subunit interface; other site 317936013251 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013252 Walker A/P-loop; other site 317936013253 ATP binding site [chemical binding]; other site 317936013254 ABC transporter; Region: ABC_tran; pfam00005 317936013255 Q-loop/lid; other site 317936013256 ABC transporter signature motif; other site 317936013257 Walker B; other site 317936013258 D-loop; other site 317936013259 H-loop/switch region; other site 317936013260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936013261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013262 Walker A/P-loop; other site 317936013263 ATP binding site [chemical binding]; other site 317936013264 Q-loop/lid; other site 317936013265 ABC transporter signature motif; other site 317936013266 Walker B; other site 317936013267 D-loop; other site 317936013268 H-loop/switch region; other site 317936013269 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 317936013270 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 317936013271 active site 317936013272 dimer interface [polypeptide binding]; other site 317936013273 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 317936013274 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936013275 Ligand Binding Site [chemical binding]; other site 317936013276 Molecular Tunnel; other site 317936013277 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 317936013278 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 317936013279 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 317936013280 lipoyl synthase; Provisional; Region: PRK05481 317936013281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936013282 FeS/SAM binding site; other site 317936013283 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619 317936013284 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 317936013285 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 317936013286 RNA polymerase sigma factor SigC; Validated; Region: PRK07598 317936013287 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 317936013288 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936013289 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936013290 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936013291 DNA binding residues [nucleotide binding] 317936013292 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 317936013293 metal binding site 2 [ion binding]; metal-binding site 317936013294 putative DNA binding helix; other site 317936013295 metal binding site 1 [ion binding]; metal-binding site 317936013296 dimer interface [polypeptide binding]; other site 317936013297 structural Zn2+ binding site [ion binding]; other site 317936013298 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936013299 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936013300 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936013301 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936013302 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936013303 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936013304 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 317936013305 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 317936013306 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 317936013307 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936013308 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936013309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936013311 dimer interface [polypeptide binding]; other site 317936013312 phosphorylation site [posttranslational modification] 317936013313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013314 ATP binding site [chemical binding]; other site 317936013315 Mg2+ binding site [ion binding]; other site 317936013316 G-X-G motif; other site 317936013317 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 317936013318 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 317936013319 putative active site cavity [active] 317936013320 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 317936013321 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 317936013322 Domain of unknown function DUF87; Region: DUF87; pfam01935 317936013323 AAA-like domain; Region: AAA_10; pfam12846 317936013324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 317936013325 Transcriptional regulators [Transcription]; Region: GntR; COG1802 317936013326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 317936013327 DNA-binding site [nucleotide binding]; DNA binding site 317936013328 FCD domain; Region: FCD; pfam07729 317936013329 2-isopropylmalate synthase; Validated; Region: PRK00915 317936013330 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 317936013331 active site 317936013332 catalytic residues [active] 317936013333 metal binding site [ion binding]; metal-binding site 317936013334 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 317936013335 Tic20-like protein; Region: Tic20; pfam09685 317936013336 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 317936013337 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 317936013338 ATP adenylyltransferase; Region: ATP_transf; pfam09830 317936013339 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 317936013340 protein I interface; other site 317936013341 D2 interface; other site 317936013342 protein T interface; other site 317936013343 chlorophyll binding site; other site 317936013344 beta carotene binding site; other site 317936013345 pheophytin binding site; other site 317936013346 manganese-stabilizing polypeptide interface; other site 317936013347 CP43 interface; other site 317936013348 protein L interface; other site 317936013349 oxygen evolving complex binding site; other site 317936013350 bromide binding site; other site 317936013351 quinone binding site; other site 317936013352 Fe binding site [ion binding]; other site 317936013353 core light harvesting interface; other site 317936013354 cytochrome b559 alpha subunit interface; other site 317936013355 cytochrome c-550 interface; other site 317936013356 protein J interface; other site 317936013357 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 317936013358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936013359 FeS/SAM binding site; other site 317936013360 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 317936013361 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 317936013362 HflX GTPase family; Region: HflX; cd01878 317936013363 G1 box; other site 317936013364 GTP/Mg2+ binding site [chemical binding]; other site 317936013365 Switch I region; other site 317936013366 G2 box; other site 317936013367 G3 box; other site 317936013368 Switch II region; other site 317936013369 G4 box; other site 317936013370 G5 box; other site 317936013371 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 317936013372 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 317936013373 GSH binding site [chemical binding]; other site 317936013374 catalytic residues [active] 317936013375 glutathione synthetase; Provisional; Region: PRK05246 317936013376 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 317936013377 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 317936013378 cell division protein FtsZ; Validated; Region: PRK09330 317936013379 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 317936013380 nucleotide binding site [chemical binding]; other site 317936013381 SulA interaction site; other site 317936013382 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 317936013383 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 317936013384 AAA ATPase domain; Region: AAA_16; pfam13191 317936013385 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013386 AAA ATPase domain; Region: AAA_16; pfam13191 317936013387 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936013388 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936013389 structural tetrad; other site 317936013390 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936013391 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936013392 structural tetrad; other site 317936013393 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936013394 structural tetrad; other site 317936013395 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716 317936013396 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 317936013397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936013398 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936013399 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936013400 DNA binding residues [nucleotide binding] 317936013401 magnesium chelatase, H subunit; Region: BchH; TIGR02025 317936013402 photosystem I reaction center subunit VIII; Reviewed; Region: psaI; PRK11877 317936013403 PsbJ; Region: PsbJ; pfam01788 317936013404 cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561 317936013405 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 317936013406 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283 317936013407 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 317936013408 Ycf48-like protein; Provisional; Region: PRK13684 317936013409 Rubredoxin [Energy production and conversion]; Region: COG1773 317936013410 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 317936013411 iron binding site [ion binding]; other site 317936013412 NADH dehydrogenase subunit 3; Region: ndhC; CHL00022 317936013413 NADH dehydrogenase subunit K; Region: ndhK; CHL00023 317936013414 NADH dehydrogenase subunit J; Provisional; Region: PRK12494 317936013415 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 317936013416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 317936013417 Walker A motif; other site 317936013418 ATP binding site [chemical binding]; other site 317936013419 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013420 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013421 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013422 binding surface 317936013423 TPR motif; other site 317936013424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013426 binding surface 317936013427 TPR motif; other site 317936013428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013430 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013431 binding surface 317936013432 TPR motif; other site 317936013433 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 317936013434 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 317936013435 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 317936013436 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 317936013437 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 317936013438 hinge; other site 317936013439 active site 317936013440 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 317936013441 GDP-Fucose binding site [chemical binding]; other site 317936013442 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 317936013443 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 317936013444 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 317936013445 active site 317936013446 substrate binding site [chemical binding]; other site 317936013447 FMN binding site [chemical binding]; other site 317936013448 putative catalytic residues [active] 317936013449 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 317936013450 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 317936013451 homotetramer interface [polypeptide binding]; other site 317936013452 ligand binding site [chemical binding]; other site 317936013453 catalytic site [active] 317936013454 NAD binding site [chemical binding]; other site 317936013455 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 317936013456 Mechanosensitive ion channel; Region: MS_channel; pfam00924 317936013457 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 317936013458 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 317936013459 NADP binding site [chemical binding]; other site 317936013460 substrate binding site [chemical binding]; other site 317936013461 active site 317936013462 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 317936013463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936013464 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 317936013465 substrate binding pocket [chemical binding]; other site 317936013466 dimerization interface [polypeptide binding]; other site 317936013467 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936013468 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013469 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936013470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013471 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936013472 Uncharacterized conserved protein [Function unknown]; Region: COG3391 317936013473 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 317936013474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013475 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 317936013476 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 317936013477 dimerization interface [polypeptide binding]; other site 317936013478 putative active cleft [active] 317936013479 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936013480 putative active site [active] 317936013481 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 317936013482 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 317936013483 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 317936013484 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 317936013485 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 317936013486 hypothetical protein; Provisional; Region: PRK07377 317936013487 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567 317936013488 tellurite resistance protein terB; Region: terB; cd07176 317936013489 putative metal binding site [ion binding]; other site 317936013490 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 317936013491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 317936013492 nucleotide binding site [chemical binding]; other site 317936013493 Photosystem I protein M (PsaM); Region: PsaM; cl15374 317936013494 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 317936013495 putative efflux protein, MATE family; Region: matE; TIGR00797 317936013496 cation binding site [ion binding]; other site 317936013497 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936013498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936013499 active site 317936013500 phosphorylation site [posttranslational modification] 317936013501 intermolecular recognition site; other site 317936013502 dimerization interface [polypeptide binding]; other site 317936013503 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 317936013504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013505 putative active site [active] 317936013506 heme pocket [chemical binding]; other site 317936013507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013508 dimer interface [polypeptide binding]; other site 317936013509 phosphorylation site [posttranslational modification] 317936013510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013511 ATP binding site [chemical binding]; other site 317936013512 Mg2+ binding site [ion binding]; other site 317936013513 G-X-G motif; other site 317936013514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013515 PAS fold; Region: PAS_3; pfam08447 317936013516 putative active site [active] 317936013517 heme pocket [chemical binding]; other site 317936013518 PAS domain S-box; Region: sensory_box; TIGR00229 317936013519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013520 putative active site [active] 317936013521 heme pocket [chemical binding]; other site 317936013522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 317936013523 Histidine kinase; Region: HisKA_2; pfam07568 317936013524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013525 ATP binding site [chemical binding]; other site 317936013526 Mg2+ binding site [ion binding]; other site 317936013527 G-X-G motif; other site 317936013528 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 317936013529 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 317936013530 active site 317936013531 trimer interface [polypeptide binding]; other site 317936013532 allosteric site; other site 317936013533 active site lid [active] 317936013534 hexamer (dimer of trimers) interface [polypeptide binding]; other site 317936013535 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 317936013536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936013537 active site 317936013538 motif I; other site 317936013539 motif II; other site 317936013540 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 317936013541 RuvA N terminal domain; Region: RuvA_N; pfam01330 317936013542 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 317936013543 Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722 317936013544 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 317936013545 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 317936013546 generic binding surface II; other site 317936013547 generic binding surface I; other site 317936013548 recombinase A; Provisional; Region: recA; PRK09354 317936013549 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 317936013550 hexamer interface [polypeptide binding]; other site 317936013551 Walker A motif; other site 317936013552 ATP binding site [chemical binding]; other site 317936013553 Walker B motif; other site 317936013554 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936013555 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936013556 phosphopeptide binding site; other site 317936013557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936013558 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936013559 active site 317936013560 ATP binding site [chemical binding]; other site 317936013561 substrate binding site [chemical binding]; other site 317936013562 activation loop (A-loop); other site 317936013563 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936013564 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936013565 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936013566 glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482 317936013567 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 317936013568 inhibitor-cofactor binding pocket; inhibition site 317936013569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936013570 catalytic residue [active] 317936013571 Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572 317936013572 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 317936013573 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 317936013574 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 317936013575 metal binding site [ion binding]; metal-binding site 317936013576 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 317936013577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936013578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936013579 active site 317936013580 phosphorylation site [posttranslational modification] 317936013581 intermolecular recognition site; other site 317936013582 dimerization interface [polypeptide binding]; other site 317936013583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936013584 DNA binding site [nucleotide binding] 317936013585 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 317936013586 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 317936013587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936013588 motif II; other site 317936013589 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 317936013590 active site 317936013591 ribulose/triose binding site [chemical binding]; other site 317936013592 phosphate binding site [ion binding]; other site 317936013593 substrate (anthranilate) binding pocket [chemical binding]; other site 317936013594 product (indole) binding pocket [chemical binding]; other site 317936013595 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936013596 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936013597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013598 dimer interface [polypeptide binding]; other site 317936013599 phosphorylation site [posttranslational modification] 317936013600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013601 ATP binding site [chemical binding]; other site 317936013602 Mg2+ binding site [ion binding]; other site 317936013603 G-X-G motif; other site 317936013604 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936013605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936013606 active site 317936013607 phosphorylation site [posttranslational modification] 317936013608 intermolecular recognition site; other site 317936013609 dimerization interface [polypeptide binding]; other site 317936013610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936013611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 317936013612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936013613 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 317936013614 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 317936013615 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 317936013616 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 317936013617 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 317936013618 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 317936013619 Putative restriction endonuclease; Region: Uma2; pfam05685 317936013620 Caspase domain; Region: Peptidase_C14; pfam00656 317936013621 Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499 317936013622 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936013623 putative active site [active] 317936013624 PAS domain S-box; Region: sensory_box; TIGR00229 317936013625 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013626 putative active site [active] 317936013627 heme pocket [chemical binding]; other site 317936013628 PAS fold; Region: PAS_4; pfam08448 317936013629 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013630 putative active site [active] 317936013631 heme pocket [chemical binding]; other site 317936013632 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936013633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013634 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 317936013635 putative active site [active] 317936013636 heme pocket [chemical binding]; other site 317936013637 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013638 putative active site [active] 317936013639 heme pocket [chemical binding]; other site 317936013640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936013641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013642 dimer interface [polypeptide binding]; other site 317936013643 phosphorylation site [posttranslational modification] 317936013644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013645 ATP binding site [chemical binding]; other site 317936013646 Mg2+ binding site [ion binding]; other site 317936013647 G-X-G motif; other site 317936013648 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 317936013649 active site 317936013650 catalytic residues [active] 317936013651 DNA binding site [nucleotide binding] 317936013652 Int/Topo IB signature motif; other site 317936013653 TSC-22/dip/bun family; Region: TSC22; pfam01166 317936013654 Sporulation and spore germination; Region: Germane; cl11253 317936013655 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 317936013656 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 317936013657 Caspase domain; Region: Peptidase_C14; pfam00656 317936013658 Uncharacterized conserved protein [Function unknown]; Region: COG1262 317936013659 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 317936013660 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 317936013661 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936013662 P-loop; other site 317936013663 Magnesium ion binding site [ion binding]; other site 317936013664 NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180 317936013665 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 317936013666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 317936013667 Uncharacterized conserved protein [Function unknown]; Region: COG0327 317936013668 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 317936013669 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 317936013670 metal binding site [ion binding]; metal-binding site 317936013671 Uncharacterized conserved protein [Function unknown]; Region: COG0432 317936013672 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 317936013673 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 317936013674 active site 317936013675 FMN binding site [chemical binding]; other site 317936013676 substrate binding site [chemical binding]; other site 317936013677 homotetramer interface [polypeptide binding]; other site 317936013678 catalytic residue [active] 317936013679 GDYXXLXY protein; Region: GDYXXLXY; cl02066 317936013680 Predicted membrane protein [Function unknown]; Region: COG4872 317936013681 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 317936013682 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 317936013683 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 317936013684 putative active site [active] 317936013685 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 317936013686 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 317936013687 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 317936013688 putative active site [active] 317936013689 putative NTP binding site [chemical binding]; other site 317936013690 putative nucleic acid binding site [nucleotide binding]; other site 317936013691 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 317936013692 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 317936013693 motif 1; other site 317936013694 active site 317936013695 motif 2; other site 317936013696 motif 3; other site 317936013697 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 317936013698 response regulator PleD; Reviewed; Region: pleD; PRK09581 317936013699 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936013700 metal binding site [ion binding]; metal-binding site 317936013701 active site 317936013702 I-site; other site 317936013703 DIL domain; Region: DIL; pfam01843 317936013704 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870 317936013705 UbiA prenyltransferase family; Region: UbiA; pfam01040 317936013706 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 317936013707 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 317936013708 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 317936013709 ATP-grasp domain; Region: ATP-grasp_4; cl17255 317936013710 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 317936013711 homodimer interface [polypeptide binding]; other site 317936013712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936013713 catalytic residue [active] 317936013714 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 317936013715 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936013716 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 317936013717 putative ADP-binding pocket [chemical binding]; other site 317936013718 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 317936013719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936013720 dimer interface [polypeptide binding]; other site 317936013721 conserved gate region; other site 317936013722 putative PBP binding loops; other site 317936013723 ABC-ATPase subunit interface; other site 317936013724 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936013725 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936013726 active site 317936013727 ATP binding site [chemical binding]; other site 317936013728 substrate binding site [chemical binding]; other site 317936013729 activation loop (A-loop); other site 317936013730 Uncharacterized conserved protein [Function unknown]; Region: COG1262 317936013731 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 317936013732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936013733 non-specific DNA binding site [nucleotide binding]; other site 317936013734 salt bridge; other site 317936013735 sequence-specific DNA binding site [nucleotide binding]; other site 317936013736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 317936013737 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936013738 dimerization interface [polypeptide binding]; other site 317936013739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936013740 putative active site [active] 317936013741 heme pocket [chemical binding]; other site 317936013742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013743 dimer interface [polypeptide binding]; other site 317936013744 phosphorylation site [posttranslational modification] 317936013745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013746 ATP binding site [chemical binding]; other site 317936013747 Mg2+ binding site [ion binding]; other site 317936013748 G-X-G motif; other site 317936013749 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 317936013750 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 317936013751 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 317936013752 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 317936013753 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936013754 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 317936013755 NAD(P) binding site [chemical binding]; other site 317936013756 active site 317936013757 Rapsyn N-terminal myristoylation and linker region; Region: Rapsyn_N; pfam10579 317936013758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013759 binding surface 317936013760 TPR motif; other site 317936013761 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013762 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013763 binding surface 317936013764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013765 TPR motif; other site 317936013766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013767 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013768 CHAT domain; Region: CHAT; pfam12770 317936013769 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 317936013770 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 317936013771 iron-sulfur cluster [ion binding]; other site 317936013772 [2Fe-2S] cluster binding site [ion binding]; other site 317936013773 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 317936013774 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 317936013775 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 317936013776 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 317936013777 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 317936013778 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 317936013779 putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574 317936013780 Uncharacterized conserved protein [Function unknown]; Region: COG4301 317936013781 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936013782 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 317936013783 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 317936013784 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 317936013785 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 317936013786 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 317936013787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013788 Walker A/P-loop; other site 317936013789 ATP binding site [chemical binding]; other site 317936013790 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 317936013791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936013792 ATP binding site [chemical binding]; other site 317936013793 putative Mg++ binding site [ion binding]; other site 317936013794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936013795 nucleotide binding region [chemical binding]; other site 317936013796 ATP-binding site [chemical binding]; other site 317936013797 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 317936013798 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 317936013799 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 317936013800 Catalytic site [active] 317936013801 ornithine carbamoyltransferase; Provisional; Region: PRK00779 317936013802 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 317936013803 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 317936013804 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 317936013805 hypothetical protein; Region: PHA01623 317936013806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 317936013807 ATP binding site [chemical binding]; other site 317936013808 putative Mg++ binding site [ion binding]; other site 317936013809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936013810 nucleotide binding region [chemical binding]; other site 317936013811 ATP-binding site [chemical binding]; other site 317936013812 Methyltransferase domain; Region: Methyltransf_26; pfam13659 317936013813 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 317936013814 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 317936013815 oligomeric interface; other site 317936013816 putative active site [active] 317936013817 homodimer interface [polypeptide binding]; other site 317936013818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936013819 ATP-binding site [chemical binding]; other site 317936013820 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 317936013821 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 317936013822 PLD-like domain; Region: PLDc_2; pfam13091 317936013823 putative active site [active] 317936013824 catalytic site [active] 317936013825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 317936013826 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 317936013827 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 317936013828 active site 317936013829 catalytic triad [active] 317936013830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936013831 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 317936013832 Walker A motif; other site 317936013833 ATP binding site [chemical binding]; other site 317936013834 Walker B motif; other site 317936013835 arginine finger; other site 317936013836 TniQ; Region: TniQ; pfam06527 317936013837 Bacterial TniB protein; Region: TniB; pfam05621 317936013838 AAA domain; Region: AAA_22; pfam13401 317936013839 Helix-turn-helix domain; Region: HTH_28; pfam13518 317936013840 Winged helix-turn helix; Region: HTH_29; pfam13551 317936013841 Integrase core domain; Region: rve; pfam00665 317936013842 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 317936013843 Response regulator receiver domain; Region: Response_reg; pfam00072 317936013844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936013845 active site 317936013846 phosphorylation site [posttranslational modification] 317936013847 intermolecular recognition site; other site 317936013848 dimerization interface [polypeptide binding]; other site 317936013849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936013850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936013851 dimer interface [polypeptide binding]; other site 317936013852 phosphorylation site [posttranslational modification] 317936013853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013854 ATP binding site [chemical binding]; other site 317936013855 Mg2+ binding site [ion binding]; other site 317936013856 G-X-G motif; other site 317936013857 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 317936013858 CHASE2 domain; Region: CHASE2; pfam05226 317936013859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013860 dimer interface [polypeptide binding]; other site 317936013861 phosphorylation site [posttranslational modification] 317936013862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013863 ATP binding site [chemical binding]; other site 317936013864 Mg2+ binding site [ion binding]; other site 317936013865 G-X-G motif; other site 317936013866 Response regulator receiver domain; Region: Response_reg; pfam00072 317936013867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936013868 active site 317936013869 phosphorylation site [posttranslational modification] 317936013870 intermolecular recognition site; other site 317936013871 dimerization interface [polypeptide binding]; other site 317936013872 Domain of Unknown Function (DUF928); Region: DUF928; pfam06051 317936013873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 317936013874 TPR motif; other site 317936013875 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013876 binding surface 317936013877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936013878 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013879 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013880 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013881 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013882 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013883 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013884 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013885 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013886 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013887 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013888 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013889 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013890 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013891 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013892 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013893 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013894 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013895 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013896 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936013897 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013898 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936013899 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 317936013900 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936013901 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936013902 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936013903 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936013904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936013905 dimer interface [polypeptide binding]; other site 317936013906 phosphorylation site [posttranslational modification] 317936013907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936013908 ATP binding site [chemical binding]; other site 317936013909 Mg2+ binding site [ion binding]; other site 317936013910 G-X-G motif; other site 317936013911 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936013912 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936013913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936013914 Walker A/P-loop; other site 317936013915 ATP binding site [chemical binding]; other site 317936013916 Q-loop/lid; other site 317936013917 ABC transporter signature motif; other site 317936013918 Walker B; other site 317936013919 D-loop; other site 317936013920 H-loop/switch region; other site 317936013921 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936013922 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936013923 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 317936013924 Walker A/P-loop; other site 317936013925 ATP binding site [chemical binding]; other site 317936013926 Q-loop/lid; other site 317936013927 ABC transporter signature motif; other site 317936013928 Walker B; other site 317936013929 D-loop; other site 317936013930 H-loop/switch region; other site 317936013931 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936013932 putative active site [active] 317936013933 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013935 binding surface 317936013936 TPR motif; other site 317936013937 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013939 binding surface 317936013940 TPR motif; other site 317936013941 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013944 binding surface 317936013945 TPR motif; other site 317936013946 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013947 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013948 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013950 binding surface 317936013951 TPR motif; other site 317936013952 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013953 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013954 CHAT domain; Region: CHAT; pfam12770 317936013955 Predicted membrane protein [Function unknown]; Region: COG3650 317936013956 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 317936013957 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 317936013958 active site 317936013959 dimerization interface [polypeptide binding]; other site 317936013960 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 317936013961 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 317936013962 Catalytic site; other site 317936013963 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936013964 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936013965 catalytic loop [active] 317936013966 iron binding site [ion binding]; other site 317936013967 CHAT domain; Region: CHAT; pfam12770 317936013968 TPR repeat; Region: TPR_11; pfam13414 317936013969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013970 binding surface 317936013971 TPR motif; other site 317936013972 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013973 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013975 binding surface 317936013976 TPR motif; other site 317936013977 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 317936013978 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 317936013979 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 317936013980 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 317936013981 MoxR-like ATPases [General function prediction only]; Region: COG0714 317936013982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936013983 Walker A motif; other site 317936013984 ATP binding site [chemical binding]; other site 317936013985 Walker B motif; other site 317936013986 arginine finger; other site 317936013987 Protein of unknown function (DUF2281); Region: DUF2281; pfam10047 317936013988 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 317936013989 Protein of unknown function DUF58; Region: DUF58; pfam01882 317936013990 TPR repeat; Region: TPR_11; pfam13414 317936013991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013992 binding surface 317936013993 TPR motif; other site 317936013994 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936013996 binding surface 317936013997 TPR motif; other site 317936013998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936013999 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014001 binding surface 317936014002 TPR motif; other site 317936014003 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014004 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 317936014005 Protein of unknown function (DUF1269); Region: DUF1269; pfam06897 317936014006 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 317936014007 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 317936014008 RDD family; Region: RDD; pfam06271 317936014009 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 317936014010 ArsC family; Region: ArsC; pfam03960 317936014011 catalytic residue [active] 317936014012 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 317936014013 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 317936014014 HIGH motif; other site 317936014015 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 317936014016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 317936014017 active site 317936014018 KMSKS motif; other site 317936014019 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 317936014020 tRNA binding surface [nucleotide binding]; other site 317936014021 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 317936014022 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 317936014023 active site 317936014024 metal binding site [ion binding]; metal-binding site 317936014025 DNA binding site [nucleotide binding] 317936014026 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936014027 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014028 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936014029 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014030 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014031 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014032 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936014033 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014034 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014036 TPR motif; other site 317936014037 binding surface 317936014038 TPR repeat; Region: TPR_11; pfam13414 317936014039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014040 binding surface 317936014041 TPR repeat; Region: TPR_11; pfam13414 317936014042 TPR motif; other site 317936014043 TPR repeat; Region: TPR_11; pfam13414 317936014044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014045 binding surface 317936014046 TPR motif; other site 317936014047 TPR repeat; Region: TPR_11; pfam13414 317936014048 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 317936014049 hypothetical protein; Provisional; Region: PRK02509 317936014050 Uncharacterized conserved protein [Function unknown]; Region: COG1615 317936014051 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 317936014052 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 317936014053 oligomer interface [polypeptide binding]; other site 317936014054 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936014055 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936014056 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936014057 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 317936014058 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 317936014059 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 317936014060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 317936014061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014062 active site 317936014063 phosphorylation site [posttranslational modification] 317936014064 intermolecular recognition site; other site 317936014065 dimerization interface [polypeptide binding]; other site 317936014066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 317936014067 DNA binding site [nucleotide binding] 317936014068 Hpt domain; Region: Hpt; pfam01627 317936014069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014070 active site 317936014071 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 317936014072 phosphorylation site [posttranslational modification] 317936014073 intermolecular recognition site; other site 317936014074 dimerization interface [polypeptide binding]; other site 317936014075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014076 active site 317936014077 phosphorylation site [posttranslational modification] 317936014078 intermolecular recognition site; other site 317936014079 dimerization interface [polypeptide binding]; other site 317936014080 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936014081 metal binding site [ion binding]; metal-binding site 317936014082 active site 317936014083 I-site; other site 317936014084 Response regulator receiver domain; Region: Response_reg; pfam00072 317936014085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014086 active site 317936014087 phosphorylation site [posttranslational modification] 317936014088 intermolecular recognition site; other site 317936014089 dimerization interface [polypeptide binding]; other site 317936014090 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 317936014091 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 317936014092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 317936014093 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 317936014094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936014095 dimer interface [polypeptide binding]; other site 317936014096 putative metal binding site [ion binding]; other site 317936014097 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 317936014098 Resolvase, N terminal domain; Region: Resolvase; smart00857 317936014099 Recombinase; Region: Recombinase; pfam07508 317936014100 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 317936014101 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 317936014102 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936014103 ribosome recycling factor; Reviewed; Region: frr; PRK00083 317936014104 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 317936014105 hinge region; other site 317936014106 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 317936014107 putative nucleotide binding site [chemical binding]; other site 317936014108 uridine monophosphate binding site [chemical binding]; other site 317936014109 homohexameric interface [polypeptide binding]; other site 317936014110 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 317936014111 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936014112 putative catalytic residue [active] 317936014113 hydrolase, alpha/beta fold family protein; Region: PLN02824 317936014114 Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622 317936014115 Protein of unknown function (DUF497); Region: DUF497; pfam04365 317936014116 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 317936014117 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936014118 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936014119 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936014120 clan AA aspartic protease, AF_0612 family; Region: clan_AA_DTGF; TIGR03698 317936014121 Predicted membrane protein [Function unknown]; Region: COG4270 317936014122 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 317936014123 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432 317936014124 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 317936014125 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 317936014126 Mechanosensitive ion channel; Region: MS_channel; pfam00924 317936014127 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 317936014128 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 317936014129 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 317936014130 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 317936014131 Walker A/P-loop; other site 317936014132 ATP binding site [chemical binding]; other site 317936014133 Q-loop/lid; other site 317936014134 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 317936014135 ABC transporter signature motif; other site 317936014136 Walker B; other site 317936014137 D-loop; other site 317936014138 H-loop/switch region; other site 317936014139 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 317936014140 ABC1 family; Region: ABC1; pfam03109 317936014141 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 317936014142 active site 317936014143 ATP binding site [chemical binding]; other site 317936014144 Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685 317936014145 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 317936014146 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 317936014147 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936014148 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 317936014149 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 317936014150 S-layer homology domain; Region: SLH; pfam00395 317936014151 S-layer homology domain; Region: SLH; pfam00395 317936014152 S-layer homology domain; Region: SLH; pfam00395 317936014153 S-layer homology domain; Region: SLH; pfam00395 317936014154 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 317936014155 nucleophilic elbow; other site 317936014156 catalytic triad; other site 317936014157 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 317936014158 S-layer homology domain; Region: SLH; pfam00395 317936014159 S-layer homology domain; Region: SLH; pfam00395 317936014160 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 317936014161 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 317936014162 TPP-binding site; other site 317936014163 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 317936014164 PYR/PP interface [polypeptide binding]; other site 317936014165 dimer interface [polypeptide binding]; other site 317936014166 TPP binding site [chemical binding]; other site 317936014167 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 317936014168 PAS fold; Region: PAS; pfam00989 317936014169 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936014170 putative active site [active] 317936014171 heme pocket [chemical binding]; other site 317936014172 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936014173 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936014174 metal binding site [ion binding]; metal-binding site 317936014175 active site 317936014176 I-site; other site 317936014177 Response regulator receiver domain; Region: Response_reg; pfam00072 317936014178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014179 active site 317936014180 phosphorylation site [posttranslational modification] 317936014181 intermolecular recognition site; other site 317936014182 dimerization interface [polypeptide binding]; other site 317936014183 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936014184 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 317936014185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 317936014186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936014187 homodimer interface [polypeptide binding]; other site 317936014188 catalytic residue [active] 317936014189 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 317936014190 catalytic residues [active] 317936014191 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 317936014192 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 317936014193 Protein of unknown function (DUF721); Region: DUF721; cl02324 317936014194 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 317936014195 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 317936014196 substrate binding site [chemical binding]; other site 317936014197 oxyanion hole (OAH) forming residues; other site 317936014198 trimer interface [polypeptide binding]; other site 317936014199 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936014200 Protein of unknown function (DUF2887); Region: DUF2887; pfam11103 317936014201 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936014202 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 317936014203 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 317936014204 dimer interface [polypeptide binding]; other site 317936014205 tetramer interface [polypeptide binding]; other site 317936014206 PYR/PP interface [polypeptide binding]; other site 317936014207 TPP binding site [chemical binding]; other site 317936014208 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 317936014209 TPP-binding site; other site 317936014210 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 317936014211 homooctamer interface [polypeptide binding]; other site 317936014212 active site 317936014213 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 317936014214 putative active site pocket [active] 317936014215 dimerization interface [polypeptide binding]; other site 317936014216 putative catalytic residue [active] 317936014217 Putative zinc-finger; Region: zf-HC2; pfam13490 317936014218 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 317936014219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936014220 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 317936014221 DNA binding residues [nucleotide binding] 317936014222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 317936014223 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 317936014224 Late competence development protein ComFB; Region: ComFB; pfam10719 317936014225 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936014226 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936014227 Membrane transport protein; Region: Mem_trans; cl09117 317936014228 glycine dehydrogenase; Provisional; Region: PRK05367 317936014229 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 317936014230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936014231 tetramer interface [polypeptide binding]; other site 317936014232 catalytic residue [active] 317936014233 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 317936014234 tetramer interface [polypeptide binding]; other site 317936014235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936014236 catalytic residue [active] 317936014237 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 317936014238 lipoyl attachment site [posttranslational modification]; other site 317936014239 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 317936014240 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 317936014241 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 317936014242 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014243 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 317936014244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014245 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014246 Protein of unknown function (DUF760); Region: DUF760; pfam05542 317936014247 BON domain; Region: BON; pfam04972 317936014248 extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262 317936014249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936014250 substrate binding pocket [chemical binding]; other site 317936014251 membrane-bound complex binding site; other site 317936014252 hinge residues; other site 317936014253 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 317936014254 TrkA-N domain; Region: TrkA_N; pfam02254 317936014255 TrkA-N domain; Region: TrkA_N; pfam02254 317936014256 TrkA-C domain; Region: TrkA_C; pfam02080 317936014257 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 317936014258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014259 binding surface 317936014260 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936014261 TPR motif; other site 317936014262 TPR repeat; Region: TPR_11; pfam13414 317936014263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014264 binding surface 317936014265 TPR motif; other site 317936014266 TPR repeat; Region: TPR_11; pfam13414 317936014267 AAA ATPase domain; Region: AAA_16; pfam13191 317936014268 AAA domain; Region: AAA_22; pfam13401 317936014269 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936014270 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936014271 structural tetrad; other site 317936014272 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936014273 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936014274 structural tetrad; other site 317936014275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 317936014276 AAA domain; Region: AAA_22; pfam13401 317936014277 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 317936014278 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 317936014279 putative NAD(P) binding site [chemical binding]; other site 317936014280 putative substrate binding site [chemical binding]; other site 317936014281 catalytic Zn binding site [ion binding]; other site 317936014282 structural Zn binding site [ion binding]; other site 317936014283 dimer interface [polypeptide binding]; other site 317936014284 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 317936014285 KTSC domain; Region: KTSC; pfam13619 317936014286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014287 Response regulator receiver domain; Region: Response_reg; pfam00072 317936014288 active site 317936014289 phosphorylation site [posttranslational modification] 317936014290 intermolecular recognition site; other site 317936014291 dimerization interface [polypeptide binding]; other site 317936014292 GAF domain; Region: GAF; cl17456 317936014293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014295 dimer interface [polypeptide binding]; other site 317936014296 phosphorylation site [posttranslational modification] 317936014297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014298 ATP binding site [chemical binding]; other site 317936014299 Mg2+ binding site [ion binding]; other site 317936014300 G-X-G motif; other site 317936014301 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 317936014302 GAF domain; Region: GAF; pfam01590 317936014303 Phytochrome region; Region: PHY; pfam00360 317936014304 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014305 dimer interface [polypeptide binding]; other site 317936014306 phosphorylation site [posttranslational modification] 317936014307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014308 ATP binding site [chemical binding]; other site 317936014309 Mg2+ binding site [ion binding]; other site 317936014310 G-X-G motif; other site 317936014311 Response regulator receiver domain; Region: Response_reg; pfam00072 317936014312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014313 active site 317936014314 phosphorylation site [posttranslational modification] 317936014315 intermolecular recognition site; other site 317936014316 dimerization interface [polypeptide binding]; other site 317936014317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 317936014318 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936014319 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936014320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936014321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936014322 Walker A/P-loop; other site 317936014323 ATP binding site [chemical binding]; other site 317936014324 Q-loop/lid; other site 317936014325 ABC transporter signature motif; other site 317936014326 Walker B; other site 317936014327 D-loop; other site 317936014328 H-loop/switch region; other site 317936014329 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 317936014330 molybdopterin synthase sulfurylase MoeB; Region: moeB; TIGR02355 317936014331 ATP binding site [chemical binding]; other site 317936014332 substrate interface [chemical binding]; other site 317936014333 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 317936014334 YcaO-like family; Region: YcaO; pfam02624 317936014335 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 317936014336 putative FMN binding site [chemical binding]; other site 317936014337 NADPH bind site [chemical binding]; other site 317936014338 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 317936014339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 317936014340 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 317936014341 putative dimerization interface [polypeptide binding]; other site 317936014342 Domain of unknown function (DUF202); Region: DUF202; pfam02656 317936014343 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 317936014344 Uncharacterized conserved protein [Function unknown]; Region: COG0432 317936014345 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014346 putative active site [active] 317936014347 LabA_like proteins; Region: LabA_like; cd06167 317936014348 putative metal binding site [ion binding]; other site 317936014349 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 317936014350 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 317936014351 dimerization interface [polypeptide binding]; other site 317936014352 active site 317936014353 metal binding site [ion binding]; metal-binding site 317936014354 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 317936014355 dsRNA binding site [nucleotide binding]; other site 317936014356 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 317936014357 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014359 dimer interface [polypeptide binding]; other site 317936014360 phosphorylation site [posttranslational modification] 317936014361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014362 ATP binding site [chemical binding]; other site 317936014363 Mg2+ binding site [ion binding]; other site 317936014364 G-X-G motif; other site 317936014365 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 317936014366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936014367 dimer interface [polypeptide binding]; other site 317936014368 conserved gate region; other site 317936014369 putative PBP binding loops; other site 317936014370 ABC-ATPase subunit interface; other site 317936014371 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 317936014372 NMT1-like family; Region: NMT1_2; pfam13379 317936014373 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 317936014374 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 317936014375 Walker A/P-loop; other site 317936014376 ATP binding site [chemical binding]; other site 317936014377 Q-loop/lid; other site 317936014378 ABC transporter signature motif; other site 317936014379 Walker B; other site 317936014380 D-loop; other site 317936014381 H-loop/switch region; other site 317936014382 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 317936014383 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 317936014384 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 317936014385 transmembrane helices; other site 317936014386 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 317936014387 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 317936014388 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 317936014389 ligand binding site [chemical binding]; other site 317936014390 Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154 317936014391 Rab subfamily motif 1 (RabSF1); other site 317936014392 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 317936014393 G1 box; other site 317936014394 GTP/Mg2+ binding site [chemical binding]; other site 317936014395 Rab subfamily motif 2 (RabSF2); other site 317936014396 Switch I region; other site 317936014397 G2 box; other site 317936014398 effector interaction site; other site 317936014399 GDI interaction site; other site 317936014400 Rab family motif 1 (RabF1); other site 317936014401 GEF interaction site [polypeptide binding]; other site 317936014402 Rab family motif 2 (RabF2); other site 317936014403 G3 box; other site 317936014404 Switch II region; other site 317936014405 Rab family motif 3 (RabF3); other site 317936014406 Rab family motif 4 (RabF4); other site 317936014407 Rab family motif 5 (RabF5); other site 317936014408 Rab subfamily motif 3 (RabSF3); other site 317936014409 G4 box; other site 317936014410 G5 box; other site 317936014411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014413 ATP binding site [chemical binding]; other site 317936014414 Mg2+ binding site [ion binding]; other site 317936014415 G-X-G motif; other site 317936014416 putative high light inducible protein; Region: PHA02337 317936014417 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 317936014418 dimer interface [polypeptide binding]; other site 317936014419 putative PBP binding regions; other site 317936014420 ABC-ATPase subunit interface; other site 317936014421 DNA primase; Validated; Region: dnaG; PRK05667 317936014422 CHC2 zinc finger; Region: zf-CHC2; pfam01807 317936014423 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 317936014424 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 317936014425 active site 317936014426 metal binding site [ion binding]; metal-binding site 317936014427 interdomain interaction site; other site 317936014428 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 317936014429 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 317936014430 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 317936014431 active site 317936014432 metal binding site [ion binding]; metal-binding site 317936014433 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 317936014434 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 317936014435 dimerization interface [polypeptide binding]; other site 317936014436 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 317936014437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 317936014438 metal binding site [ion binding]; metal-binding site 317936014439 active site 317936014440 I-site; other site 317936014441 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 317936014442 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 317936014443 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 317936014444 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 317936014445 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 317936014446 Surface antigen; Region: Bac_surface_Ag; pfam01103 317936014447 conserved hypothetical protein; Region: TIGR03492 317936014448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 317936014449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936014450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014451 active site 317936014452 phosphorylation site [posttranslational modification] 317936014453 intermolecular recognition site; other site 317936014454 dimerization interface [polypeptide binding]; other site 317936014455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936014456 DNA binding residues [nucleotide binding] 317936014457 dimerization interface [polypeptide binding]; other site 317936014458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 317936014459 PAS domain; Region: PAS_9; pfam13426 317936014460 putative active site [active] 317936014461 heme pocket [chemical binding]; other site 317936014462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014463 ATP binding site [chemical binding]; other site 317936014464 G-X-G motif; other site 317936014465 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936014466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014467 active site 317936014468 phosphorylation site [posttranslational modification] 317936014469 intermolecular recognition site; other site 317936014470 dimerization interface [polypeptide binding]; other site 317936014471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014472 dimer interface [polypeptide binding]; other site 317936014473 phosphorylation site [posttranslational modification] 317936014474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014475 ATP binding site [chemical binding]; other site 317936014476 Mg2+ binding site [ion binding]; other site 317936014477 G-X-G motif; other site 317936014478 Response regulator receiver domain; Region: Response_reg; pfam00072 317936014479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014480 active site 317936014481 phosphorylation site [posttranslational modification] 317936014482 intermolecular recognition site; other site 317936014483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014484 dimerization interface [polypeptide binding]; other site 317936014485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014486 dimer interface [polypeptide binding]; other site 317936014487 phosphorylation site [posttranslational modification] 317936014488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014489 ATP binding site [chemical binding]; other site 317936014490 Mg2+ binding site [ion binding]; other site 317936014491 G-X-G motif; other site 317936014492 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936014493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936014494 active site 317936014495 phosphorylation site [posttranslational modification] 317936014496 intermolecular recognition site; other site 317936014497 dimerization interface [polypeptide binding]; other site 317936014498 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 317936014499 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 317936014500 active site 317936014501 metal binding site [ion binding]; metal-binding site 317936014502 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 317936014503 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936014504 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936014505 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 317936014506 Glucose inhibited division protein A; Region: GIDA; pfam01134 317936014507 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014508 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936014509 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 317936014510 Fe-S cluster binding site [ion binding]; other site 317936014511 active site 317936014512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 317936014513 active site 317936014514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014515 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014516 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014517 binding surface 317936014518 TPR motif; other site 317936014519 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014520 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014522 binding surface 317936014523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014524 TPR motif; other site 317936014525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 317936014527 S-adenosylmethionine binding site [chemical binding]; other site 317936014528 ubiquinone biosynthesis methyltransferase; Region: PLN02232 317936014529 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 317936014530 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 317936014531 dimerization interface [polypeptide binding]; other site 317936014532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014534 dimer interface [polypeptide binding]; other site 317936014535 phosphorylation site [posttranslational modification] 317936014536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014537 ATP binding site [chemical binding]; other site 317936014538 Mg2+ binding site [ion binding]; other site 317936014539 G-X-G motif; other site 317936014540 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 317936014541 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 317936014542 substrate binding pocket [chemical binding]; other site 317936014543 membrane-bound complex binding site; other site 317936014544 Protein kinase domain; Region: Pkinase; pfam00069 317936014545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936014546 active site 317936014547 ATP binding site [chemical binding]; other site 317936014548 substrate binding site [chemical binding]; other site 317936014549 activation loop (A-loop); other site 317936014550 AAA ATPase domain; Region: AAA_16; pfam13191 317936014551 Predicted ATPase [General function prediction only]; Region: COG3899 317936014552 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014553 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936014554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014556 dimer interface [polypeptide binding]; other site 317936014557 phosphorylation site [posttranslational modification] 317936014558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014559 ATP binding site [chemical binding]; other site 317936014560 Mg2+ binding site [ion binding]; other site 317936014561 G-X-G motif; other site 317936014562 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 317936014563 Protein kinase; unclassified specificity; Region: STYKc; smart00221 317936014564 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936014565 active site 317936014566 ATP binding site [chemical binding]; other site 317936014567 substrate binding site [chemical binding]; other site 317936014568 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 317936014569 substrate binding site [chemical binding]; other site 317936014570 activation loop (A-loop); other site 317936014571 activation loop (A-loop); other site 317936014572 AAA ATPase domain; Region: AAA_16; pfam13191 317936014573 Predicted ATPase [General function prediction only]; Region: COG3899 317936014574 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014575 GAF domain; Region: GAF; pfam01590 317936014576 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014577 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936014578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014580 ATP binding site [chemical binding]; other site 317936014581 Mg2+ binding site [ion binding]; other site 317936014582 G-X-G motif; other site 317936014583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 317936014584 PAS domain; Region: PAS_9; pfam13426 317936014585 putative active site [active] 317936014586 heme pocket [chemical binding]; other site 317936014587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014588 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936014589 GAF domain; Region: GAF; pfam01590 317936014590 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936014591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936014592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936014593 dimer interface [polypeptide binding]; other site 317936014594 phosphorylation site [posttranslational modification] 317936014595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936014596 ATP binding site [chemical binding]; other site 317936014597 Mg2+ binding site [ion binding]; other site 317936014598 G-X-G motif; other site 317936014599 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 317936014600 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 317936014601 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936014602 FAD binding domain; Region: FAD_binding_4; pfam01565 317936014603 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 317936014604 Ion channel; Region: Ion_trans_2; pfam07885 317936014605 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 317936014606 TrkA-N domain; Region: TrkA_N; pfam02254 317936014607 TrkA-C domain; Region: TrkA_C; pfam02080 317936014608 acetylornithine aminotransferase; Provisional; Region: PRK02627 317936014609 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 317936014610 inhibitor-cofactor binding pocket; inhibition site 317936014611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 317936014612 catalytic residue [active] 317936014613 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936014614 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 317936014615 putative C-terminal domain interface [polypeptide binding]; other site 317936014616 putative GSH binding site (G-site) [chemical binding]; other site 317936014617 putative dimer interface [polypeptide binding]; other site 317936014618 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 317936014619 N-terminal domain interface [polypeptide binding]; other site 317936014620 dimer interface [polypeptide binding]; other site 317936014621 substrate binding pocket (H-site) [chemical binding]; other site 317936014622 Predicted permeases [General function prediction only]; Region: COG0795 317936014623 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 317936014624 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 317936014625 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 317936014626 Walker A/P-loop; other site 317936014627 ATP binding site [chemical binding]; other site 317936014628 Q-loop/lid; other site 317936014629 ABC transporter signature motif; other site 317936014630 Walker B; other site 317936014631 D-loop; other site 317936014632 H-loop/switch region; other site 317936014633 OstA-like protein; Region: OstA; pfam03968 317936014634 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 317936014635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 317936014636 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 317936014637 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 317936014638 active site 317936014639 catalytic residues [active] 317936014640 DNA binding site [nucleotide binding] 317936014641 Int/Topo IB signature motif; other site 317936014642 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 317936014643 tape measure domain; Region: tape_meas_nterm; TIGR02675 317936014644 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936014645 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 317936014646 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 317936014647 TPR repeat; Region: TPR_11; pfam13414 317936014648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014649 binding surface 317936014650 TPR motif; other site 317936014651 TPR repeat; Region: TPR_11; pfam13414 317936014652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014653 binding surface 317936014654 TPR motif; other site 317936014655 PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155 317936014656 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 317936014657 Mg binding site [ion binding]; other site 317936014658 nucleotide binding site [chemical binding]; other site 317936014659 putative protofilament interface [polypeptide binding]; other site 317936014660 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936014661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936014662 active site 317936014663 ATP binding site [chemical binding]; other site 317936014664 substrate binding site [chemical binding]; other site 317936014665 activation loop (A-loop); other site 317936014666 arginine-tRNA ligase; Region: PLN02286 317936014667 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 317936014668 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 317936014669 active site 317936014670 HIGH motif; other site 317936014671 KMSK motif region; other site 317936014672 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 317936014673 tRNA binding surface [nucleotide binding]; other site 317936014674 anticodon binding site; other site 317936014675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 317936014676 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936014677 Cytochrome P450; Region: p450; pfam00067 317936014678 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 317936014679 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 317936014680 P-loop; other site 317936014681 Magnesium ion binding site [ion binding]; other site 317936014682 haemagglutination activity domain; Region: Haemagg_act; pfam05860 317936014683 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 317936014684 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 317936014685 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 317936014686 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936014687 putative metal binding site [ion binding]; other site 317936014688 Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513 317936014689 putative di-iron ligands [ion binding]; other site 317936014690 Tic20-like protein; Region: Tic20; pfam09685 317936014691 EURL protein; Region: EURL; pfam06937 317936014692 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 317936014693 Peptidase family M50; Region: Peptidase_M50; pfam02163 317936014694 active site 317936014695 putative substrate binding region [chemical binding]; other site 317936014696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801 317936014697 FOG: CBS domain [General function prediction only]; Region: COG0517 317936014698 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 317936014699 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936014700 active site 317936014701 catalytic tetrad [active] 317936014702 Uncharacterized conserved protein [Function unknown]; Region: COG1259 317936014703 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 317936014704 Lumazine binding domain; Region: Lum_binding; pfam00677 317936014705 Lumazine binding domain; Region: Lum_binding; pfam00677 317936014706 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 317936014707 Peptidase family M23; Region: Peptidase_M23; pfam01551 317936014708 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 317936014709 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 317936014710 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 317936014711 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 317936014712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936014713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 317936014714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936014715 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 317936014716 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014717 putative active site [active] 317936014718 photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042 317936014719 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 317936014720 hydroxyglutarate oxidase; Provisional; Region: PRK11728 317936014721 haloalkane dehalogenase; Provisional; Region: PRK03592 317936014722 TIGR00701 family protein; Region: TIGR00701 317936014723 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 317936014724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 317936014725 ligand binding site [chemical binding]; other site 317936014726 flexible hinge region; other site 317936014727 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 317936014728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936014729 Walker A motif; other site 317936014730 ATP binding site [chemical binding]; other site 317936014731 Walker B motif; other site 317936014732 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 317936014733 4Fe-4S binding domain; Region: Fer4_5; pfam12801 317936014734 Bacterial sugar transferase; Region: Bac_transf; pfam02397 317936014735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 317936014736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936014737 dimer interface [polypeptide binding]; other site 317936014738 conserved gate region; other site 317936014739 putative PBP binding loops; other site 317936014740 ABC-ATPase subunit interface; other site 317936014741 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 317936014742 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 317936014743 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936014744 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936014745 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 317936014746 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 317936014747 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 317936014748 NADP binding site [chemical binding]; other site 317936014749 active site 317936014750 putative substrate binding site [chemical binding]; other site 317936014751 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 317936014752 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 317936014753 NADP-binding site; other site 317936014754 homotetramer interface [polypeptide binding]; other site 317936014755 substrate binding site [chemical binding]; other site 317936014756 homodimer interface [polypeptide binding]; other site 317936014757 active site 317936014758 Bacterial sugar transferase; Region: Bac_transf; pfam02397 317936014759 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 317936014760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 317936014761 putative ADP-binding pocket [chemical binding]; other site 317936014762 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 317936014763 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 317936014764 putative NAD(P) binding site [chemical binding]; other site 317936014765 active site 317936014766 UDP-glucose 4-epimerase C-term subunit; Region: Epimerase_Csub; pfam13950 317936014767 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014768 putative active site [active] 317936014769 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 317936014770 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 317936014771 NAD binding site [chemical binding]; other site 317936014772 substrate binding site [chemical binding]; other site 317936014773 homodimer interface [polypeptide binding]; other site 317936014774 active site 317936014775 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 317936014776 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 317936014777 substrate binding site; other site 317936014778 tetramer interface; other site 317936014779 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 317936014780 TPR repeat; Region: TPR_11; pfam13414 317936014781 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014783 binding surface 317936014784 TPR motif; other site 317936014785 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014786 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014788 binding surface 317936014789 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014790 TPR motif; other site 317936014791 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014792 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014793 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014794 binding surface 317936014795 TPR motif; other site 317936014796 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936014798 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014799 putative active site [active] 317936014800 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 317936014801 Aspartase; Region: Aspartase; cd01357 317936014802 active sites [active] 317936014803 tetramer interface [polypeptide binding]; other site 317936014804 Uncharacterized conserved protein [Function unknown]; Region: COG2006 317936014805 Domain of unknown function (DUF362); Region: DUF362; pfam04015 317936014806 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014807 putative active site [active] 317936014808 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 317936014809 CoA binding domain; Region: CoA_binding_2; pfam13380 317936014810 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 317936014811 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 317936014812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 317936014813 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 317936014814 Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066 317936014815 nickel binding site [ion binding]; other site 317936014816 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 317936014817 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 317936014818 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 317936014819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936014820 motif II; other site 317936014821 30S ribosomal protein S1; Reviewed; Region: PRK07400 317936014822 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 317936014823 RNA binding site [nucleotide binding]; other site 317936014824 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 317936014825 RNA binding site [nucleotide binding]; other site 317936014826 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 317936014827 RNA binding site [nucleotide binding]; other site 317936014828 photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875 317936014829 photosystem II 47 kDa protein; Region: psbB; CHL00062 317936014830 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 317936014831 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 317936014832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 317936014833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936014834 dimer interface [polypeptide binding]; other site 317936014835 conserved gate region; other site 317936014836 putative PBP binding loops; other site 317936014837 ABC-ATPase subunit interface; other site 317936014838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 317936014839 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 317936014840 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 317936014841 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 317936014842 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 317936014843 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 317936014844 glutamine binding [chemical binding]; other site 317936014845 catalytic triad [active] 317936014846 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 317936014847 metal-binding heat shock protein; Provisional; Region: PRK00016 317936014848 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 317936014849 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 317936014850 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 317936014851 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408 317936014852 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 317936014853 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 317936014854 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 317936014855 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014856 putative active site [active] 317936014857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936014858 magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031 317936014859 Walker A motif; other site 317936014860 ATP binding site [chemical binding]; other site 317936014861 Walker B motif; other site 317936014862 arginine finger; other site 317936014863 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 317936014864 metal ion-dependent adhesion site (MIDAS); other site 317936014865 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 317936014866 NADH(P)-binding; Region: NAD_binding_10; pfam13460 317936014867 NAD(P) binding site [chemical binding]; other site 317936014868 putative active site [active] 317936014869 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936014870 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936014871 structural tetrad; other site 317936014872 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936014873 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 317936014874 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 317936014875 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936014876 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 317936014877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 317936014878 Flavodoxin; Region: Flavodoxin_1; pfam00258 317936014879 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 317936014880 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 317936014881 argininosuccinate synthase; Provisional; Region: PRK13820 317936014882 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 317936014883 ANP binding site [chemical binding]; other site 317936014884 Substrate Binding Site II [chemical binding]; other site 317936014885 Substrate Binding Site I [chemical binding]; other site 317936014886 NB-ARC domain; Region: NB-ARC; pfam00931 317936014887 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014889 Tetratricopeptide repeat; Region: TPR_10; pfam13374 317936014890 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014891 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014892 binding surface 317936014893 TPR motif; other site 317936014894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014895 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014897 binding surface 317936014898 TPR motif; other site 317936014899 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014900 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014902 binding surface 317936014903 TPR motif; other site 317936014904 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014905 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014907 binding surface 317936014908 TPR motif; other site 317936014909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014910 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014911 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014912 binding surface 317936014913 TPR motif; other site 317936014914 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936014916 binding surface 317936014917 TPR motif; other site 317936014918 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014919 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936014920 Tetratricopeptide repeat; Region: TPR_10; pfam13374 317936014921 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014922 putative active site [active] 317936014923 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936014924 putative active site [active] 317936014925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936014926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936014927 active site 317936014928 ATP binding site [chemical binding]; other site 317936014929 substrate binding site [chemical binding]; other site 317936014930 activation loop (A-loop); other site 317936014931 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936014932 structural tetrad; other site 317936014933 PQQ-like domain; Region: PQQ_2; pfam13360 317936014934 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 317936014935 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 317936014936 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 317936014937 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 317936014938 MgtE intracellular N domain; Region: MgtE_N; smart00924 317936014939 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 317936014940 Divalent cation transporter; Region: MgtE; pfam01769 317936014941 acylphosphatase; Provisional; Region: PRK14423 317936014942 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 317936014943 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 317936014944 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 317936014945 glycogen binding site [chemical binding]; other site 317936014946 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350 317936014947 active site 317936014948 catalytic site [active] 317936014949 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 317936014950 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 317936014951 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 317936014952 cyanophycin synthetase; Provisional; Region: PRK14016 317936014953 ATP-grasp domain; Region: ATP-grasp_4; cl17255 317936014954 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 317936014955 proposed catalytic triad [active] 317936014956 active site nucleophile [active] 317936014957 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 317936014958 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 317936014959 NAD(P) binding site [chemical binding]; other site 317936014960 catalytic residues [active] 317936014961 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582 317936014962 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 317936014963 putative active site [active] 317936014964 catalytic triad [active] 317936014965 putative dimer interface [polypeptide binding]; other site 317936014966 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 317936014967 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 317936014968 putative dimer interface [polypeptide binding]; other site 317936014969 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 317936014970 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936014971 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 317936014972 Coenzyme A binding pocket [chemical binding]; other site 317936014973 AMIN domain; Region: AMIN; pfam11741 317936014974 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 317936014975 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 317936014976 mercuric reductase; Validated; Region: PRK06370 317936014977 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936014978 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 317936014979 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 317936014980 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 317936014981 Uncharacterized conserved protein [Function unknown]; Region: COG0398 317936014982 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 317936014983 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 317936014984 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 317936014985 Probable Catalytic site; other site 317936014986 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 317936014987 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 317936014988 RNA binding surface [nucleotide binding]; other site 317936014989 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 317936014990 CP12 domain; Region: CP12; pfam02672 317936014991 Dynamin family; Region: Dynamin_N; pfam00350 317936014992 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 317936014993 G1 box; other site 317936014994 GTP/Mg2+ binding site [chemical binding]; other site 317936014995 Switch I region; other site 317936014996 G2 box; other site 317936014997 Switch II region; other site 317936014998 G3 box; other site 317936014999 G4 box; other site 317936015000 G5 box; other site 317936015001 Domain of unknown function (DUF697); Region: DUF697; pfam05128 317936015002 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 317936015003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015004 putative active site [active] 317936015005 heme pocket [chemical binding]; other site 317936015006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 317936015007 dimer interface [polypeptide binding]; other site 317936015008 phosphorylation site [posttranslational modification] 317936015009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936015010 ATP binding site [chemical binding]; other site 317936015011 Mg2+ binding site [ion binding]; other site 317936015012 G-X-G motif; other site 317936015013 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 317936015014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 317936015015 Zn2+ binding site [ion binding]; other site 317936015016 Mg2+ binding site [ion binding]; other site 317936015017 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 317936015018 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 317936015019 metal ion-dependent adhesion site (MIDAS); other site 317936015020 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936015021 Domain of unknown function (DUF4351); Region: DUF4351; pfam14261 317936015022 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 317936015023 ATP binding site [chemical binding]; other site 317936015024 substrate interface [chemical binding]; other site 317936015025 S-layer homology domain; Region: SLH; pfam00395 317936015026 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936015027 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 317936015028 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 317936015029 intersubunit interface [polypeptide binding]; other site 317936015030 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 317936015031 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 317936015032 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 317936015033 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 317936015034 Predicted metal-binding protein [Function unknown]; Region: COG5469 317936015035 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 317936015036 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 317936015037 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 317936015038 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 317936015039 PBP superfamily domain; Region: PBP_like_2; cl17296 317936015040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936015041 membrane-bound complex binding site; other site 317936015042 hinge residues; other site 317936015043 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 317936015044 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936015045 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 317936015046 Domain of unknown function (DUF305); Region: DUF305; pfam03713 317936015047 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 317936015048 metal-binding site [ion binding] 317936015049 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 317936015050 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 317936015051 [2Fe-2S] cluster binding site [ion binding]; other site 317936015052 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 317936015053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936015054 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936015055 TPR repeat; Region: TPR_11; pfam13414 317936015056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015057 binding surface 317936015058 TPR motif; other site 317936015059 TPR repeat; Region: TPR_11; pfam13414 317936015060 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936015061 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 317936015062 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 317936015063 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 317936015064 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 317936015065 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 317936015066 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 317936015067 metal-binding site [ion binding] 317936015068 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936015069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 317936015070 motif II; other site 317936015071 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 317936015072 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 317936015073 phosphopeptide binding site; other site 317936015074 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 317936015075 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 317936015076 putative NAD(P) binding site [chemical binding]; other site 317936015077 putative active site [active] 317936015078 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 317936015079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015080 binding surface 317936015081 TPR motif; other site 317936015082 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 317936015083 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 317936015084 9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732 317936015085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936015086 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 317936015087 putative hydrophobic ligand binding site [chemical binding]; other site 317936015088 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 317936015089 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 317936015090 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 317936015091 catalytic loop [active] 317936015092 iron binding site [ion binding]; other site 317936015093 cobyric acid synthase; Provisional; Region: PRK00784 317936015094 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 317936015095 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 317936015096 catalytic triad [active] 317936015097 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 317936015098 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 317936015099 catalytic triad [active] 317936015100 ABC-2 type transporter; Region: ABC2_membrane; cl17235 317936015101 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 317936015102 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936015103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015104 Walker A/P-loop; other site 317936015105 ATP binding site [chemical binding]; other site 317936015106 Q-loop/lid; other site 317936015107 ABC transporter signature motif; other site 317936015108 Walker B; other site 317936015109 D-loop; other site 317936015110 H-loop/switch region; other site 317936015111 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 317936015112 AAA domain; Region: AAA_33; pfam13671 317936015113 active site 317936015114 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 317936015115 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 317936015116 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 317936015117 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 317936015118 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 317936015119 ATP binding site [chemical binding]; other site 317936015120 Mg++ binding site [ion binding]; other site 317936015121 motif III; other site 317936015122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 317936015123 nucleotide binding region [chemical binding]; other site 317936015124 ATP-binding site [chemical binding]; other site 317936015125 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 317936015126 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 317936015127 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 317936015128 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 317936015129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015130 Walker A/P-loop; other site 317936015131 ATP binding site [chemical binding]; other site 317936015132 AAA domain; Region: AAA_21; pfam13304 317936015133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015134 Q-loop/lid; other site 317936015135 ABC transporter signature motif; other site 317936015136 Walker B; other site 317936015137 D-loop; other site 317936015138 H-loop/switch region; other site 317936015139 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 317936015140 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 317936015141 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 317936015142 hexamer interface [polypeptide binding]; other site 317936015143 ligand binding site [chemical binding]; other site 317936015144 putative active site [active] 317936015145 NAD(P) binding site [chemical binding]; other site 317936015146 light-harvesting-like protein 3; Provisional; Region: PLN00014 317936015147 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936015148 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 317936015149 structural tetrad; other site 317936015150 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 317936015151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402 317936015152 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 317936015153 Predicted transcriptional regulators [Transcription]; Region: COG1695 317936015154 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 317936015155 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 317936015156 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 317936015157 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 317936015158 Family of unknown function (DUF490); Region: DUF490; pfam04357 317936015159 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 317936015160 Cadmium resistance transporter; Region: Cad; pfam03596 317936015161 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 317936015162 Uncharacterized conserved protein [Function unknown]; Region: COG4925 317936015163 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 317936015164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 317936015165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 317936015166 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 317936015167 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 317936015168 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 317936015169 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 317936015170 substrate binding site [chemical binding]; other site 317936015171 active site 317936015172 catalytic residues [active] 317936015173 heterodimer interface [polypeptide binding]; other site 317936015174 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 317936015175 MarR family; Region: MarR; pfam01047 317936015176 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 317936015177 metal binding site [ion binding]; metal-binding site 317936015178 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 317936015179 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 317936015180 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 317936015181 putative dimer interface [polypeptide binding]; other site 317936015182 N-terminal domain interface [polypeptide binding]; other site 317936015183 putative substrate binding pocket (H-site) [chemical binding]; other site 317936015184 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 317936015185 RibD C-terminal domain; Region: RibD_C; cl17279 317936015186 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 317936015187 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 317936015188 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 317936015189 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 317936015190 NADH(P)-binding; Region: NAD_binding_10; pfam13460 317936015191 NAD(P) binding site [chemical binding]; other site 317936015192 putative active site [active] 317936015193 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 317936015194 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 317936015195 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936015196 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936015197 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936015198 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936015199 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936015200 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 317936015201 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 317936015202 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 317936015203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 317936015204 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 317936015205 Domain of unknown function (DUF309); Region: DUF309; pfam03745 317936015206 ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165 317936015207 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 317936015208 Protein of unknown function DUF58; Region: DUF58; pfam01882 317936015209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 317936015210 Mg2+ binding site [ion binding]; other site 317936015211 G-X-G motif; other site 317936015212 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 317936015213 ATP binding site [chemical binding]; other site 317936015214 GMP synthase; Reviewed; Region: guaA; PRK00074 317936015215 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 317936015216 AMP/PPi binding site [chemical binding]; other site 317936015217 candidate oxyanion hole; other site 317936015218 catalytic triad [active] 317936015219 potential glutamine specificity residues [chemical binding]; other site 317936015220 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 317936015221 ATP Binding subdomain [chemical binding]; other site 317936015222 Ligand Binding sites [chemical binding]; other site 317936015223 Dimerization subdomain; other site 317936015224 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 317936015225 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 317936015226 CP12 domain; Region: CP12; pfam02672 317936015227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 317936015228 FIST N domain; Region: FIST; pfam08495 317936015229 FIST C domain; Region: FIST_C; pfam10442 317936015230 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 317936015231 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 317936015232 active site 317936015233 metal binding site [ion binding]; metal-binding site 317936015234 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 317936015235 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936015236 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 317936015237 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 317936015238 phosphoenolpyruvate synthase; Validated; Region: PRK06464 317936015239 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 317936015240 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 317936015241 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 317936015242 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 317936015243 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 317936015244 dimer interface [polypeptide binding]; other site 317936015245 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 317936015246 active site 317936015247 Fe binding site [ion binding]; other site 317936015248 LabA_like proteins; Region: LabA_like; cd06167 317936015249 putative metal binding site [ion binding]; other site 317936015250 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258 317936015251 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 317936015252 Walker A/P-loop; other site 317936015253 ATP binding site [chemical binding]; other site 317936015254 Q-loop/lid; other site 317936015255 ABC transporter signature motif; other site 317936015256 Walker B; other site 317936015257 D-loop; other site 317936015258 H-loop/switch region; other site 317936015259 PBP superfamily domain; Region: PBP_like_2; cl17296 317936015260 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 317936015261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936015262 dimer interface [polypeptide binding]; other site 317936015263 conserved gate region; other site 317936015264 putative PBP binding loops; other site 317936015265 ABC-ATPase subunit interface; other site 317936015266 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 317936015267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936015268 dimer interface [polypeptide binding]; other site 317936015269 conserved gate region; other site 317936015270 putative PBP binding loops; other site 317936015271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 317936015272 ABC-ATPase subunit interface; other site 317936015273 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 317936015274 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 317936015275 Walker A/P-loop; other site 317936015276 ATP binding site [chemical binding]; other site 317936015277 Q-loop/lid; other site 317936015278 ABC transporter signature motif; other site 317936015279 Walker B; other site 317936015280 D-loop; other site 317936015281 H-loop/switch region; other site 317936015282 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 317936015283 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936015284 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936015285 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 317936015286 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 317936015287 NADP binding site [chemical binding]; other site 317936015288 homodimer interface [polypeptide binding]; other site 317936015289 active site 317936015290 substrate binding site [chemical binding]; other site 317936015291 Rubrerythrin [Energy production and conversion]; Region: COG1592 317936015292 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 317936015293 binuclear metal center [ion binding]; other site 317936015294 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 317936015295 iron binding site [ion binding]; other site 317936015296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015297 TPR repeat; Region: TPR_11; pfam13414 317936015298 binding surface 317936015299 TPR motif; other site 317936015300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015301 binding surface 317936015302 TPR motif; other site 317936015303 TPR repeat; Region: TPR_11; pfam13414 317936015304 TPR repeat; Region: TPR_11; pfam13414 317936015305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015306 binding surface 317936015307 TPR motif; other site 317936015308 TPR repeat; Region: TPR_11; pfam13414 317936015309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015310 binding surface 317936015311 TPR repeat; Region: TPR_11; pfam13414 317936015312 TPR motif; other site 317936015313 TPR repeat; Region: TPR_11; pfam13414 317936015314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015315 binding surface 317936015316 TPR motif; other site 317936015317 TPR repeat; Region: TPR_11; pfam13414 317936015318 TPR repeat; Region: TPR_11; pfam13414 317936015319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015320 binding surface 317936015321 TPR motif; other site 317936015322 TPR repeat; Region: TPR_11; pfam13414 317936015323 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015324 binding surface 317936015325 TPR repeat; Region: TPR_11; pfam13414 317936015326 TPR motif; other site 317936015327 Cupin domain; Region: Cupin_2; cl17218 317936015328 HEAT repeats; Region: HEAT_2; pfam13646 317936015329 HEAT repeats; Region: HEAT_2; pfam13646 317936015330 HEAT repeats; Region: HEAT_2; pfam13646 317936015331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 317936015332 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 317936015333 Coenzyme A binding pocket [chemical binding]; other site 317936015334 AmpG-like permease; Region: 2A0125; TIGR00901 317936015335 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 317936015336 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 317936015337 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 317936015338 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 317936015339 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015340 binding surface 317936015341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015342 TPR motif; other site 317936015343 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015344 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015348 binding surface 317936015349 TPR motif; other site 317936015350 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015351 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015352 binding surface 317936015353 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015354 TPR motif; other site 317936015355 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015356 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015358 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015359 binding surface 317936015360 TPR motif; other site 317936015361 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015364 binding surface 317936015365 TPR motif; other site 317936015366 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015367 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995 317936015369 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 317936015370 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936015371 putative active site [active] 317936015372 Transposase IS200 like; Region: Y1_Tnp; pfam01797 317936015373 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 317936015374 Probable transposase; Region: OrfB_IS605; pfam01385 317936015375 Protein of unknown function (DUF1822); Region: DUF1822; pfam08852 317936015376 Uncharacterized conserved protein [Function unknown]; Region: COG5464 317936015377 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 317936015378 phosphate transporter ATP-binding protein; Provisional; Region: PRK14243 317936015379 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 317936015380 Walker A/P-loop; other site 317936015381 ATP binding site [chemical binding]; other site 317936015382 Q-loop/lid; other site 317936015383 ABC transporter signature motif; other site 317936015384 Walker B; other site 317936015385 D-loop; other site 317936015386 H-loop/switch region; other site 317936015387 polyphosphate kinase; Provisional; Region: PRK05443 317936015388 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 317936015389 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 317936015390 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 317936015391 putative domain interface [polypeptide binding]; other site 317936015392 putative active site [active] 317936015393 catalytic site [active] 317936015394 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 317936015395 putative domain interface [polypeptide binding]; other site 317936015396 putative active site [active] 317936015397 catalytic site [active] 317936015398 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 317936015399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 317936015400 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 317936015401 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 317936015402 structural tetrad; other site 317936015403 FOG: WD40 repeat [General function prediction only]; Region: COG2319 317936015404 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 317936015405 structural tetrad; other site 317936015406 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 317936015407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015408 Walker A/P-loop; other site 317936015409 ATP binding site [chemical binding]; other site 317936015410 Q-loop/lid; other site 317936015411 ABC transporter signature motif; other site 317936015412 Walker B; other site 317936015413 D-loop; other site 317936015414 H-loop/switch region; other site 317936015415 ABC-2 type transporter; Region: ABC2_membrane; cl17235 317936015416 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 317936015417 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 317936015418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936015419 substrate binding pocket [chemical binding]; other site 317936015420 membrane-bound complex binding site; other site 317936015421 hinge residues; other site 317936015422 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 317936015423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015424 Walker A/P-loop; other site 317936015425 ATP binding site [chemical binding]; other site 317936015426 Q-loop/lid; other site 317936015427 ABC transporter signature motif; other site 317936015428 Walker B; other site 317936015429 D-loop; other site 317936015430 H-loop/switch region; other site 317936015431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936015432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936015433 active site 317936015434 catalytic tetrad [active] 317936015435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 317936015436 Predicted esterase [General function prediction only]; Region: COG0400 317936015437 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 317936015438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 317936015439 Probable transposase; Region: OrfB_IS605; pfam01385 317936015440 Transposase IS200 like; Region: Y1_Tnp; pfam01797 317936015441 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 317936015442 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 317936015443 active site 317936015444 non-prolyl cis peptide bond; other site 317936015445 S-layer homology domain; Region: SLH; pfam00395 317936015446 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 317936015447 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 317936015448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936015449 dimer interface [polypeptide binding]; other site 317936015450 conserved gate region; other site 317936015451 putative PBP binding loops; other site 317936015452 ABC-ATPase subunit interface; other site 317936015453 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 317936015454 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 317936015455 Walker A/P-loop; other site 317936015456 ATP binding site [chemical binding]; other site 317936015457 Q-loop/lid; other site 317936015458 ABC transporter signature motif; other site 317936015459 Walker B; other site 317936015460 D-loop; other site 317936015461 H-loop/switch region; other site 317936015462 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 317936015463 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 317936015464 substrate binding pocket [chemical binding]; other site 317936015465 active site 317936015466 iron coordination sites [ion binding]; other site 317936015467 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 317936015468 putative catalytic residue [active] 317936015469 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 317936015470 clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934 317936015471 NADP binding site [chemical binding]; other site 317936015472 homotetramer interface [polypeptide binding]; other site 317936015473 homodimer interface [polypeptide binding]; other site 317936015474 active site 317936015475 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936015476 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 317936015477 C-terminal domain interface [polypeptide binding]; other site 317936015478 GSH binding site (G-site) [chemical binding]; other site 317936015479 dimer interface [polypeptide binding]; other site 317936015480 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 317936015481 N-terminal domain interface [polypeptide binding]; other site 317936015482 dimer interface [polypeptide binding]; other site 317936015483 substrate binding pocket (H-site) [chemical binding]; other site 317936015484 H+ Antiporter protein; Region: 2A0121; TIGR00900 317936015485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936015486 putative substrate translocation pore; other site 317936015487 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 317936015488 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 317936015489 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 317936015490 substrate binding pocket [chemical binding]; other site 317936015491 membrane-bound complex binding site; other site 317936015492 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 317936015493 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 317936015494 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 317936015495 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 317936015496 Putative methyltransferase; Region: Methyltransf_20; pfam12147 317936015497 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 317936015498 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 317936015499 C-terminal domain interface [polypeptide binding]; other site 317936015500 GSH binding site (G-site) [chemical binding]; other site 317936015501 dimer interface [polypeptide binding]; other site 317936015502 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 317936015503 N-terminal domain interface [polypeptide binding]; other site 317936015504 Phycobilisome protein; Region: Phycobilisome; cl08227 317936015505 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 317936015506 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 317936015507 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 317936015508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 317936015509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 317936015510 active site 317936015511 catalytic tetrad [active] 317936015512 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 317936015513 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 317936015514 substrate binding pocket [chemical binding]; other site 317936015515 membrane-bound complex binding site; other site 317936015516 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 317936015517 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 317936015518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015519 Walker A/P-loop; other site 317936015520 ATP binding site [chemical binding]; other site 317936015521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015522 ABC transporter signature motif; other site 317936015523 Walker B; other site 317936015524 D-loop; other site 317936015525 H-loop/switch region; other site 317936015526 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 317936015527 non-specific DNA binding site [nucleotide binding]; other site 317936015528 salt bridge; other site 317936015529 sequence-specific DNA binding site [nucleotide binding]; other site 317936015530 hypothetical protein; Provisional; Region: PRK06850 317936015531 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 317936015532 Active Sites [active] 317936015533 DGQHR domain; Region: DGQHR; TIGR03187 317936015534 DNA-sulfur modification-associated; Region: DndB; cl17621 317936015535 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 317936015536 HNH endonuclease; Region: HNH_2; pfam13391 317936015537 dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062 317936015538 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 317936015539 protein I interface; other site 317936015540 D2 interface; other site 317936015541 protein T interface; other site 317936015542 chlorophyll binding site; other site 317936015543 beta carotene binding site; other site 317936015544 pheophytin binding site; other site 317936015545 manganese-stabilizing polypeptide interface; other site 317936015546 CP43 interface; other site 317936015547 protein L interface; other site 317936015548 oxygen evolving complex binding site; other site 317936015549 bromide binding site; other site 317936015550 quinone binding site; other site 317936015551 Fe binding site [ion binding]; other site 317936015552 core light harvesting interface; other site 317936015553 cytochrome b559 alpha subunit interface; other site 317936015554 cytochrome c-550 interface; other site 317936015555 protein J interface; other site 317936015556 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 317936015557 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 317936015558 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 317936015559 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 317936015560 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 317936015561 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 317936015562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015563 putative active site [active] 317936015564 heme pocket [chemical binding]; other site 317936015565 GAF domain; Region: GAF; pfam01590 317936015566 Phytochrome region; Region: PHY; pfam00360 317936015567 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936015568 dimer interface [polypeptide binding]; other site 317936015569 phosphorylation site [posttranslational modification] 317936015570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936015571 ATP binding site [chemical binding]; other site 317936015572 Mg2+ binding site [ion binding]; other site 317936015573 G-X-G motif; other site 317936015574 Response regulator receiver domain; Region: Response_reg; pfam00072 317936015575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936015576 active site 317936015577 phosphorylation site [posttranslational modification] 317936015578 intermolecular recognition site; other site 317936015579 dimerization interface [polypeptide binding]; other site 317936015580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 317936015581 catalytic core [active] 317936015582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 317936015583 nudix motif; other site 317936015584 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 317936015585 HemY protein N-terminus; Region: HemY_N; pfam07219 317936015586 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015587 binding surface 317936015588 TPR motif; other site 317936015589 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936015590 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 317936015591 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 317936015592 Walker A/P-loop; other site 317936015593 ATP binding site [chemical binding]; other site 317936015594 Q-loop/lid; other site 317936015595 ABC transporter signature motif; other site 317936015596 Walker B; other site 317936015597 D-loop; other site 317936015598 H-loop/switch region; other site 317936015599 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 317936015600 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 317936015601 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 317936015602 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936015603 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 317936015604 Predicted membrane protein [Function unknown]; Region: COG1950 317936015605 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 317936015606 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015607 AAA domain; Region: AAA_21; pfam13304 317936015608 Walker A/P-loop; other site 317936015609 ATP binding site [chemical binding]; other site 317936015610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015611 ABC transporter signature motif; other site 317936015612 Walker B; other site 317936015613 D-loop; other site 317936015614 H-loop/switch region; other site 317936015615 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 317936015616 MutS domain I; Region: MutS_I; pfam01624 317936015617 MutS domain II; Region: MutS_II; pfam05188 317936015618 MutS domain III; Region: MutS_III; pfam05192 317936015619 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 317936015620 Walker A/P-loop; other site 317936015621 ATP binding site [chemical binding]; other site 317936015622 Q-loop/lid; other site 317936015623 ABC transporter signature motif; other site 317936015624 Walker B; other site 317936015625 D-loop; other site 317936015626 H-loop/switch region; other site 317936015627 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 317936015628 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 317936015629 metal-binding site [ion binding] 317936015630 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936015631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936015632 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 317936015633 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 317936015634 substrate binding pocket [chemical binding]; other site 317936015635 substrate-Mg2+ binding site; other site 317936015636 aspartate-rich region 1; other site 317936015637 active site lid residues [active] 317936015638 aspartate-rich region 2; other site 317936015639 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936015640 Cytochrome P450; Region: p450; cl12078 317936015641 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 317936015642 Catalytic domain of Protein Kinases; Region: PKc; cd00180 317936015643 active site 317936015644 ATP binding site [chemical binding]; other site 317936015645 substrate binding site [chemical binding]; other site 317936015646 activation loop (A-loop); other site 317936015647 AAA ATPase domain; Region: AAA_16; pfam13191 317936015648 Predicted ATPase [General function prediction only]; Region: COG3899 317936015649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936015650 GAF domain; Region: GAF; pfam01590 317936015651 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936015652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936015653 dimer interface [polypeptide binding]; other site 317936015654 phosphorylation site [posttranslational modification] 317936015655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936015656 ATP binding site [chemical binding]; other site 317936015657 Mg2+ binding site [ion binding]; other site 317936015658 G-X-G motif; other site 317936015659 MAPEG family; Region: MAPEG; pfam01124 317936015660 Nuclease A inhibitor-like protein; Region: NuiA; pfam07924 317936015661 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 317936015662 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 317936015663 active site 317936015664 substrate binding site [chemical binding]; other site 317936015665 Mg2+ binding site [ion binding]; other site 317936015666 PAS domain S-box; Region: sensory_box; TIGR00229 317936015667 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015668 putative active site [active] 317936015669 heme pocket [chemical binding]; other site 317936015670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936015671 GAF domain; Region: GAF; pfam01590 317936015672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936015673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936015674 dimer interface [polypeptide binding]; other site 317936015675 phosphorylation site [posttranslational modification] 317936015676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936015677 ATP binding site [chemical binding]; other site 317936015678 Mg2+ binding site [ion binding]; other site 317936015679 G-X-G motif; other site 317936015680 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936015681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936015682 active site 317936015683 phosphorylation site [posttranslational modification] 317936015684 intermolecular recognition site; other site 317936015685 dimerization interface [polypeptide binding]; other site 317936015686 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 317936015687 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 317936015688 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 317936015689 trimer interface [polypeptide binding]; other site 317936015690 active site 317936015691 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 317936015692 catalytic site [active] 317936015693 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 317936015694 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 317936015695 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 317936015696 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 317936015697 active site 317936015698 metal binding site [ion binding]; metal-binding site 317936015699 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 317936015700 Peptidase family M48; Region: Peptidase_M48; pfam01435 317936015701 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 317936015702 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 317936015703 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 317936015704 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 317936015705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015706 Walker A/P-loop; other site 317936015707 ATP binding site [chemical binding]; other site 317936015708 Q-loop/lid; other site 317936015709 ABC transporter signature motif; other site 317936015710 Walker B; other site 317936015711 D-loop; other site 317936015712 H-loop/switch region; other site 317936015713 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 317936015714 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 317936015715 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 317936015716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936015717 active site 317936015718 phosphorylation site [posttranslational modification] 317936015719 intermolecular recognition site; other site 317936015720 dimerization interface [polypeptide binding]; other site 317936015721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 317936015722 DNA binding residues [nucleotide binding] 317936015723 dimerization interface [polypeptide binding]; other site 317936015724 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936015725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936015726 active site 317936015727 phosphorylation site [posttranslational modification] 317936015728 intermolecular recognition site; other site 317936015729 dimerization interface [polypeptide binding]; other site 317936015730 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 317936015731 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 317936015732 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 317936015733 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 317936015734 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 317936015735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 317936015736 ATP binding site [chemical binding]; other site 317936015737 Mg2+ binding site [ion binding]; other site 317936015738 G-X-G motif; other site 317936015739 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 317936015740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936015741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936015742 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 317936015743 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936015744 DevC protein; Region: devC; TIGR01185 317936015745 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936015746 FtsX-like permease family; Region: FtsX; pfam02687 317936015747 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 317936015748 putative active site [active] 317936015749 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 317936015750 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936015751 Walker A/P-loop; other site 317936015752 ATP binding site [chemical binding]; other site 317936015753 Q-loop/lid; other site 317936015754 ABC transporter signature motif; other site 317936015755 Walker B; other site 317936015756 D-loop; other site 317936015757 H-loop/switch region; other site 317936015758 Tetratricopeptide repeat; Region: TPR_12; pfam13424 317936015759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 317936015760 binding surface 317936015761 TPR motif; other site 317936015762 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 317936015763 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 317936015764 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 317936015765 homotrimer interaction site [polypeptide binding]; other site 317936015766 putative active site [active] 317936015767 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 317936015768 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 317936015769 putative active site [active] 317936015770 putative NTP binding site [chemical binding]; other site 317936015771 putative nucleic acid binding site [nucleotide binding]; other site 317936015772 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 317936015773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 317936015774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 317936015775 Walker A/P-loop; other site 317936015776 ATP binding site [chemical binding]; other site 317936015777 Q-loop/lid; other site 317936015778 ABC transporter signature motif; other site 317936015779 Walker B; other site 317936015780 D-loop; other site 317936015781 H-loop/switch region; other site 317936015782 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 317936015783 Mechanosensitive ion channel; Region: MS_channel; pfam00924 317936015784 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 317936015785 tartrate dehydrogenase; Region: TTC; TIGR02089 317936015786 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 317936015787 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 317936015788 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 317936015789 Caspase domain; Region: Peptidase_C14; pfam00656 317936015790 Protein of unknown function (DUF433); Region: DUF433; cl01030 317936015791 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 317936015792 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 317936015793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936015794 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 317936015795 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 317936015796 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 317936015797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 317936015798 Walker A motif; other site 317936015799 ATP binding site [chemical binding]; other site 317936015800 Walker B motif; other site 317936015801 arginine finger; other site 317936015802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936015803 dimer interface [polypeptide binding]; other site 317936015804 conserved gate region; other site 317936015805 putative PBP binding loops; other site 317936015806 ABC-ATPase subunit interface; other site 317936015807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 317936015808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 317936015809 dimer interface [polypeptide binding]; other site 317936015810 conserved gate region; other site 317936015811 putative PBP binding loops; other site 317936015812 ABC-ATPase subunit interface; other site 317936015813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 317936015814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 317936015815 putative substrate translocation pore; other site 317936015816 AMIN domain; Region: AMIN; pfam11741 317936015817 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 317936015818 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 317936015819 N-terminal plug; other site 317936015820 ligand-binding site [chemical binding]; other site 317936015821 cytochrome c-550; Provisional; Region: psbV; PRK13618 317936015822 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 317936015823 plastocyanin; Provisional; Region: PRK02710 317936015824 Cytochrome c; Region: Cytochrom_C; cl11414 317936015825 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 317936015826 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 317936015827 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 317936015828 putative active site [active] 317936015829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 317936015830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 317936015831 Walker A/P-loop; other site 317936015832 ATP binding site [chemical binding]; other site 317936015833 Q-loop/lid; other site 317936015834 ABC transporter signature motif; other site 317936015835 Walker B; other site 317936015836 D-loop; other site 317936015837 H-loop/switch region; other site 317936015838 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 317936015839 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 317936015840 Integral membrane protein DUF92; Region: DUF92; pfam01940 317936015841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 317936015842 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 317936015843 active site 317936015844 metal binding site [ion binding]; metal-binding site 317936015845 Lipase (class 2); Region: Lipase_2; pfam01674 317936015846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 317936015847 Tetratricopeptide repeat; Region: TPR_16; pfam13432 317936015848 RNA methyltransferase, RsmE family; Region: TIGR00046 317936015849 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 317936015850 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 317936015851 Cytochrome P450; Region: p450; pfam00067 317936015852 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 317936015853 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 317936015854 Walker A/P-loop; other site 317936015855 ATP binding site [chemical binding]; other site 317936015856 Q-loop/lid; other site 317936015857 ABC transporter signature motif; other site 317936015858 Walker B; other site 317936015859 D-loop; other site 317936015860 H-loop/switch region; other site 317936015861 DevC protein; Region: devC; TIGR01185 317936015862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 317936015863 FtsX-like permease family; Region: FtsX; pfam02687 317936015864 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 317936015865 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 317936015866 HlyD family secretion protein; Region: HlyD_3; pfam13437 317936015867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 317936015868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 317936015869 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 317936015870 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 317936015871 purine monophosphate binding site [chemical binding]; other site 317936015872 dimer interface [polypeptide binding]; other site 317936015873 putative catalytic residues [active] 317936015874 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 317936015875 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 317936015876 PAS domain S-box; Region: sensory_box; TIGR00229 317936015877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015878 putative active site [active] 317936015879 heme pocket [chemical binding]; other site 317936015880 PAS domain; Region: PAS; smart00091 317936015881 PAS domain S-box; Region: sensory_box; TIGR00229 317936015882 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 317936015883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015884 PAS fold; Region: PAS_3; pfam08447 317936015885 putative active site [active] 317936015886 heme pocket [chemical binding]; other site 317936015887 PAS domain; Region: PAS_9; pfam13426 317936015888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 317936015889 putative active site [active] 317936015890 heme pocket [chemical binding]; other site 317936015891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 317936015892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 317936015893 dimer interface [polypeptide binding]; other site 317936015894 phosphorylation site [posttranslational modification] 317936015895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 317936015896 ATP binding site [chemical binding]; other site 317936015897 Mg2+ binding site [ion binding]; other site 317936015898 G-X-G motif; other site 317936015899 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 317936015900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 317936015901 active site 317936015902 phosphorylation site [posttranslational modification] 317936015903 intermolecular recognition site; other site 317936015904 dimerization interface [polypeptide binding]; other site 317936015905 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 317936015906 Ferritin-like domain; Region: Ferritin; pfam00210 317936015907 dimanganese center [ion binding]; other site 317936015908 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 317936015909 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 317936015910 FeS/SAM binding site; other site 317936015911 HemN C-terminal domain; Region: HemN_C; pfam06969 317936015912 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 317936015913 heme binding pocket [chemical binding]; other site 317936015914 heme ligand [chemical binding]; other site 317936015915 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 317936015916 diiron binding motif [ion binding]; other site 317936015917 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 317936015918 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 317936015919 c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177 317936015920 ResB-like family; Region: ResB; pfam05140 317936015921 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 317936015922 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 317936015923 Uncharacterized conserved protein [Function unknown]; Region: COG3937 317936015924 YCII-related domain; Region: YCII; cl00999 317936015925 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 317936015926 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 317936015927 tandem repeat interface [polypeptide binding]; other site 317936015928 oligomer interface [polypeptide binding]; other site 317936015929 active site residues [active] 317936015930 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 317936015931 tandem repeat interface [polypeptide binding]; other site 317936015932 oligomer interface [polypeptide binding]; other site 317936015933 active site residues [active] 317936015934 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 317936015935 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 317936015936 homotetramer interface [polypeptide binding]; other site 317936015937 FMN binding site [chemical binding]; other site 317936015938 homodimer contacts [polypeptide binding]; other site 317936015939 putative active site [active] 317936015940 putative substrate binding site [chemical binding]; other site 317936015941 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 317936015942 HEAT repeats; Region: HEAT_2; pfam13646 317936015943 protein binding surface [polypeptide binding]; other site 317936015944 HEAT repeats; Region: HEAT_2; pfam13646 317936015945 HEAT repeat; Region: HEAT; pfam02985 317936015946 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 317936015947 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 317936015948 Soluble P-type ATPase [General function prediction only]; Region: COG4087 317936015949 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 317936015950 active site 317936015951 catalytic residues [active] 317936015952 metal binding site [ion binding]; metal-binding site 317936015953 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 317936015954 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 317936015955 protein binding site [polypeptide binding]; other site