-- dump date   	20140619_165430
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
103690000001	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690000002	Helix-turn-helix domain; Region: HTH_31; pfam13560
103690000003	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
103690000004	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
103690000005	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
103690000006	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
103690000007	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
103690000008	ATP binding site [chemical binding]; other site
103690000009	substrate interface [chemical binding]; other site
103690000010	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
103690000011	active site
103690000012	NTP binding site [chemical binding]; other site
103690000013	metal binding triad [ion binding]; metal-binding site
103690000014	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
103690000015	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
103690000016	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690000017	active site
103690000018	catalytic residues [active]
103690000019	DNA binding site [nucleotide binding]
103690000020	Int/Topo IB signature motif; other site
103690000021	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
103690000022	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
103690000023	hypothetical protein; Region: PHA00684
103690000024	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
103690000025	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
103690000026	conserved cys residue [active]
103690000027	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690000028	GAF domain; Region: GAF; cl17456
103690000029	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690000030	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690000031	DNA binding residues [nucleotide binding]
103690000032	dimerization interface [polypeptide binding]; other site
103690000033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690000034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690000035	Uncharacterized conserved protein [Function unknown]; Region: COG2128
103690000036	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
103690000037	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
103690000038	Amidase; Region: Amidase; pfam01425
103690000039	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690000040	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690000041	WHG domain; Region: WHG; pfam13305
103690000042	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690000043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690000044	Walker A motif; other site
103690000045	ATP binding site [chemical binding]; other site
103690000046	Walker B motif; other site
103690000047	arginine finger; other site
103690000048	Uncharacterized conserved protein [Function unknown]; Region: COG1430
103690000049	AAA-like domain; Region: AAA_10; pfam12846
103690000050	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
103690000051	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
103690000052	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
103690000053	Walker A motif; other site
103690000054	ATP binding site [chemical binding]; other site
103690000055	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
103690000056	Walker B motif; other site
103690000057	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
103690000058	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
103690000059	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
103690000060	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690000061	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
103690000062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690000063	ATP binding site [chemical binding]; other site
103690000064	putative Mg++ binding site [ion binding]; other site
103690000065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690000066	nucleotide binding region [chemical binding]; other site
103690000067	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
103690000068	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
103690000069	polymerase nucleotide-binding site; other site
103690000070	DNA-binding residues [nucleotide binding]; DNA binding site
103690000071	nucleotide binding site [chemical binding]; other site
103690000072	primase nucleotide-binding site [nucleotide binding]; other site
103690000073	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
103690000074	Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460
103690000075	PRTRC system protein A; Region: PRTRC_A; TIGR03735
103690000076	Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464
103690000077	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
103690000078	ATP binding site [chemical binding]; other site
103690000079	substrate interface [chemical binding]; other site
103690000080	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
103690000081	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690000082	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690000083	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690000084	Homeodomain-like domain; Region: HTH_23; pfam13384
103690000085	Winged helix-turn helix; Region: HTH_29; pfam13551
103690000086	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
103690000087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000088	S-adenosylmethionine binding site [chemical binding]; other site
103690000089	DNA polymerase III subunit beta; Validated; Region: PRK05643
103690000090	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
103690000091	putative DNA binding surface [nucleotide binding]; other site
103690000092	dimer interface [polypeptide binding]; other site
103690000093	beta-clamp/clamp loader binding surface; other site
103690000094	beta-clamp/translesion DNA polymerase binding surface; other site
103690000095	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
103690000096	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690000097	Walker A motif; other site
103690000098	ATP binding site [chemical binding]; other site
103690000099	Walker B motif; other site
103690000100	arginine finger; other site
103690000101	AAA domain; Region: AAA_17; pfam13207
103690000102	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
103690000103	active site
103690000104	catalytic site [active]
103690000105	substrate binding site [chemical binding]; other site
103690000106	DNA polymerase type-B family; Region: POLBc; smart00486
103690000107	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
103690000108	active site
103690000109	metal-binding site
103690000110	DNA polymerase III subunit delta; Validated; Region: PRK07452
103690000111	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
103690000112	DNA polymerase III subunit delta'; Validated; Region: PRK07399
103690000113	DNA polymerase III subunit delta'; Validated; Region: PRK08485
103690000114	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
103690000115	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
103690000116	dimer interface [polypeptide binding]; other site
103690000117	ssDNA binding site [nucleotide binding]; other site
103690000118	tetramer (dimer of dimers) interface [polypeptide binding]; other site
103690000119	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690000120	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000121	P-loop; other site
103690000122	Magnesium ion binding site [ion binding]; other site
103690000123	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000124	Magnesium ion binding site [ion binding]; other site
103690000125	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
103690000126	ParB-like nuclease domain; Region: ParB; smart00470
103690000127	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
103690000128	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690000129	dimer interface [polypeptide binding]; other site
103690000130	phosphorylation site [posttranslational modification]
103690000131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690000132	ATP binding site [chemical binding]; other site
103690000133	Mg2+ binding site [ion binding]; other site
103690000134	G-X-G motif; other site
103690000135	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690000136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000137	active site
103690000138	phosphorylation site [posttranslational modification]
103690000139	intermolecular recognition site; other site
103690000140	dimerization interface [polypeptide binding]; other site
103690000141	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690000142	DNA binding site [nucleotide binding]
103690000143	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
103690000144	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
103690000145	dimer interface [polypeptide binding]; other site
103690000146	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690000147	catalytic residue [active]
103690000148	Progressive ankylosis protein (ANKH); Region: ANKH; pfam07260
103690000149	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690000150	Ligand Binding Site [chemical binding]; other site
103690000151	Uncharacterized conserved protein [Function unknown]; Region: COG0398
103690000152	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690000153	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
103690000154	Uncharacterized conserved protein [Function unknown]; Region: COG3350
103690000155	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
103690000156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690000157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690000158	motif II; other site
103690000159	Uncharacterized conserved protein [Function unknown]; Region: COG3350
103690000160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
103690000161	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690000162	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690000163	TPR repeat; Region: TPR_11; pfam13414
103690000164	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690000165	binding surface
103690000166	TPR motif; other site
103690000167	TPR repeat; Region: TPR_11; pfam13414
103690000168	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690000169	manganese transport protein MntH; Reviewed; Region: PRK00701
103690000170	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
103690000171	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
103690000172	Sodium Bile acid symporter family; Region: SBF; cl17470
103690000173	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
103690000174	Transthyretin_like.  This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase).  TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222
103690000175	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690000176	dimer interface [polypeptide binding]; other site
103690000177	phosphorylation site [posttranslational modification]
103690000178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690000179	ATP binding site [chemical binding]; other site
103690000180	Mg2+ binding site [ion binding]; other site
103690000181	G-X-G motif; other site
103690000182	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690000183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000184	active site
103690000185	phosphorylation site [posttranslational modification]
103690000186	intermolecular recognition site; other site
103690000187	dimerization interface [polypeptide binding]; other site
103690000188	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690000189	DNA binding site [nucleotide binding]
103690000190	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690000191	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690000192	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
103690000193	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690000194	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690000195	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690000196	DNA binding residues [nucleotide binding]
103690000197	CemA family; Region: CemA; cl03855
103690000198	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
103690000199	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
103690000200	S-layer homology domain; Region: SLH; pfam00395
103690000201	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690000202	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690000203	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
103690000204	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690000205	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690000206	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690000207	DNA binding residues [nucleotide binding]
103690000208	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690000209	putative active site [active]
103690000210	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
103690000211	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
103690000212	Protein export membrane protein; Region: SecD_SecF; cl14618
103690000213	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690000214	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
103690000215	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690000216	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
103690000217	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690000218	putative DNA binding site [nucleotide binding]; other site
103690000219	dimerization interface [polypeptide binding]; other site
103690000220	putative Zn2+ binding site [ion binding]; other site
103690000221	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
103690000222	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
103690000223	metal-binding site [ion binding]
103690000224	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
103690000225	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
103690000226	metal-binding site [ion binding]
103690000227	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690000228	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690000229	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
103690000230	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
103690000231	active site
103690000232	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690000233	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690000234	active site
103690000235	Transposase [DNA replication, recombination, and repair]; Region: COG5421
103690000236	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
103690000237	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
103690000238	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
103690000239	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
103690000240	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
103690000241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690000242	Major Facilitator Superfamily; Region: MFS_1; pfam07690
103690000243	putative substrate translocation pore; other site
103690000244	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690000245	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690000246	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690000247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690000248	putative substrate translocation pore; other site
103690000249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000250	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
103690000251	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690000252	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
103690000253	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690000254	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
103690000255	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
103690000256	dimerization interface [polypeptide binding]; other site
103690000257	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
103690000258	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
103690000259	metal-binding site [ion binding]
103690000260	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690000261	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690000262	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
103690000263	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
103690000264	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
103690000265	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
103690000266	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
103690000267	DNA binding residues [nucleotide binding]
103690000268	dimer interface [polypeptide binding]; other site
103690000269	metal binding site [ion binding]; metal-binding site
103690000270	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
103690000271	metal-binding site [ion binding]
103690000272	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
103690000273	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
103690000274	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690000275	nucleotide binding site [chemical binding]; other site
103690000276	putative protofilament interface [polypeptide binding]; other site
103690000277	conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877
103690000278	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
103690000279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000280	S-adenosylmethionine binding site [chemical binding]; other site
103690000281	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690000282	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000283	active site
103690000284	phosphorylation site [posttranslational modification]
103690000285	intermolecular recognition site; other site
103690000286	dimerization interface [polypeptide binding]; other site
103690000287	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690000288	DNA binding residues [nucleotide binding]
103690000289	dimerization interface [polypeptide binding]; other site
103690000290	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690000291	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
103690000292	Homeodomain-like domain; Region: HTH_23; pfam13384
103690000293	Winged helix-turn helix; Region: HTH_29; pfam13551
103690000294	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
103690000295	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
103690000296	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
103690000297	N-acetyl-D-glucosamine binding site [chemical binding]; other site
103690000298	catalytic residue [active]
103690000299	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690000300	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690000301	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
103690000302	TIGR02646 family protein; Region: TIGR02646
103690000303	AAA domain; Region: AAA_21; pfam13304
103690000304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690000305	Q-loop/lid; other site
103690000306	ABC transporter signature motif; other site
103690000307	Walker B; other site
103690000308	D-loop; other site
103690000309	H-loop/switch region; other site
103690000310	Domain of unknown function (DUF955); Region: DUF955; pfam06114
103690000311	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
103690000312	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
103690000313	active site
103690000314	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
103690000315	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
103690000316	active site
103690000317	DNA binding site [nucleotide binding]
103690000318	Int/Topo IB signature motif; other site
103690000319	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690000320	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000321	P-loop; other site
103690000322	Magnesium ion binding site [ion binding]; other site
103690000323	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000324	Magnesium ion binding site [ion binding]; other site
103690000325	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
103690000326	ParB-like nuclease domain; Region: ParBc; pfam02195
103690000327	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690000328	Probable transposase; Region: OrfB_IS605; pfam01385
103690000329	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690000330	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
103690000331	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
103690000332	active site
103690000333	substrate binding site [chemical binding]; other site
103690000334	Mg2+ binding site [ion binding]; other site
103690000335	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
103690000336	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
103690000337	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
103690000338	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
103690000339	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690000340	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690000341	Walker A motif; other site
103690000342	ATP binding site [chemical binding]; other site
103690000343	Walker B motif; other site
103690000344	arginine finger; other site
103690000345	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690000346	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690000347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690000348	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690000349	hypothetical protein; Reviewed; Region: PRK12275
103690000350	four helix bundle protein; Region: TIGR02436
103690000351	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
103690000352	Allene oxide synthase; Region: AOS; cd08151
103690000353	dimer interface [polypeptide binding]; other site
103690000354	heme binding pocket [chemical binding]; other site
103690000355	Lipoxygenase; Region: Lipoxygenase; pfam00305
103690000356	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690000357	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000358	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
103690000359	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
103690000360	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690000361	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000362	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
103690000363	oligomeric interface; other site
103690000364	putative active site [active]
103690000365	homodimer interface [polypeptide binding]; other site
103690000366	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
103690000367	Antirestriction protein [General function prediction only]; Region: ArdA; COG4734
103690000368	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690000369	Mg binding site [ion binding]; other site
103690000370	nucleotide binding site [chemical binding]; other site
103690000371	putative protofilament interface [polypeptide binding]; other site
103690000372	TrwC relaxase; Region: TrwC; pfam08751
103690000373	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
103690000374	AAA domain; Region: AAA_30; pfam13604
103690000375	Family description; Region: UvrD_C_2; pfam13538
103690000376	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
103690000377	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
103690000378	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
103690000379	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
103690000380	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
103690000381	Domain of unknown function DUF87; Region: DUF87; pfam01935
103690000382	AAA-like domain; Region: AAA_10; pfam12846
103690000383	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cd00525
103690000384	nucleotide binding site [chemical binding]; other site
103690000385	Replication regulatory protein RepB; Region: RepB-RCR_reg; cl11673
103690000386	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690000387	Mg binding site [ion binding]; other site
103690000388	nucleotide binding site [chemical binding]; other site
103690000389	putative protofilament interface [polypeptide binding]; other site
103690000390	NB-ARC domain; Region: NB-ARC; pfam00931
103690000391	hypothetical protein; Validated; Region: PRK00029
103690000392	Transposase [DNA replication, recombination, and repair]; Region: COG5433
103690000393	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
103690000394	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690000395	Transposase [DNA replication, recombination, and repair]; Region: COG5433
103690000396	Predicted acetyltransferase [General function prediction only]; Region: COG3393
103690000397	Coenzyme A binding pocket [chemical binding]; other site
103690000398	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690000399	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690000400	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690000401	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
103690000402	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
103690000403	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690000404	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690000405	Probable transposase; Region: OrfB_IS605; pfam01385
103690000406	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690000407	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690000408	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
103690000409	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
103690000410	potential catalytic triad [active]
103690000411	conserved cys residue [active]
103690000412	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
103690000413	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
103690000414	DEAD-like helicases superfamily; Region: DEXDc; smart00487
103690000415	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690000416	ATP binding site [chemical binding]; other site
103690000417	putative Mg++ binding site [ion binding]; other site
103690000418	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690000419	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
103690000420	nucleotide binding region [chemical binding]; other site
103690000421	ATP-binding site [chemical binding]; other site
103690000422	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
103690000423	GTPase RsgA; Reviewed; Region: PRK01889
103690000424	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
103690000425	RNA binding site [nucleotide binding]; other site
103690000426	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
103690000427	GTPase/Zn-binding domain interface [polypeptide binding]; other site
103690000428	GTP/Mg2+ binding site [chemical binding]; other site
103690000429	G4 box; other site
103690000430	G5 box; other site
103690000431	G1 box; other site
103690000432	Switch I region; other site
103690000433	G2 box; other site
103690000434	G3 box; other site
103690000435	Switch II region; other site
103690000436	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
103690000437	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
103690000438	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
103690000439	Predicted ATPase [General function prediction only]; Region: COG4637
103690000440	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690000441	Walker A/P-loop; other site
103690000442	ATP binding site [chemical binding]; other site
103690000443	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690000444	ABC transporter signature motif; other site
103690000445	Walker B; other site
103690000446	D-loop; other site
103690000447	H-loop/switch region; other site
103690000448	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
103690000449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000450	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690000451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690000452	putative DNA binding site [nucleotide binding]; other site
103690000453	putative Zn2+ binding site [ion binding]; other site
103690000454	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
103690000455	putative dimerization interface [polypeptide binding]; other site
103690000456	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
103690000457	Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157
103690000458	homodimer interface [polypeptide binding]; other site
103690000459	ligand binding site [chemical binding]; other site
103690000460	NAD binding site [chemical binding]; other site
103690000461	catalytic site [active]
103690000462	ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639
103690000463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690000464	dimer interface [polypeptide binding]; other site
103690000465	conserved gate region; other site
103690000466	putative PBP binding loops; other site
103690000467	ABC-ATPase subunit interface; other site
103690000468	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
103690000469	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
103690000470	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
103690000471	Walker A/P-loop; other site
103690000472	ATP binding site [chemical binding]; other site
103690000473	Q-loop/lid; other site
103690000474	ABC transporter signature motif; other site
103690000475	Walker B; other site
103690000476	D-loop; other site
103690000477	H-loop/switch region; other site
103690000478	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
103690000479	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
103690000480	Phage associated DNA primase [General function prediction only]; Region: COG3378
103690000481	D5 N terminal like; Region: D5_N; pfam08706
103690000482	ParG; Region: ParG; pfam09274
103690000483	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690000484	Mg binding site [ion binding]; other site
103690000485	nucleotide binding site [chemical binding]; other site
103690000486	putative protofilament interface [polypeptide binding]; other site
103690000487	Dtr system oriT relaxase; Provisional; Region: PRK13826
103690000488	AAA-like domain; Region: AAA_10; pfam12846
103690000489	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690000490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000491	active site
103690000492	phosphorylation site [posttranslational modification]
103690000493	intermolecular recognition site; other site
103690000494	dimerization interface [polypeptide binding]; other site
103690000495	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690000496	DNA binding residues [nucleotide binding]
103690000497	dimerization interface [polypeptide binding]; other site
103690000498	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690000499	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000500	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690000501	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000502	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000503	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690000504	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690000505	Double zinc ribbon; Region: DZR; pfam12773
103690000506	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690000507	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
103690000508	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
103690000509	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690000510	active site
103690000511	catalytic residues [active]
103690000512	DNA binding site [nucleotide binding]
103690000513	Int/Topo IB signature motif; other site
103690000514	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690000515	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690000516	GUN4-like; Region: GUN4; pfam05419
103690000517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
103690000518	Predicted membrane protein [Function unknown]; Region: COG5305
103690000519	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
103690000520	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
103690000521	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690000522	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000523	P-loop; other site
103690000524	Magnesium ion binding site [ion binding]; other site
103690000525	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690000526	Magnesium ion binding site [ion binding]; other site
103690000527	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
103690000528	ParB-like nuclease domain; Region: ParB; smart00470
103690000529	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
103690000530	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
103690000531	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
103690000532	core domain interface [polypeptide binding]; other site
103690000533	delta subunit interface [polypeptide binding]; other site
103690000534	epsilon subunit interface [polypeptide binding]; other site
103690000535	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
103690000536	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
103690000537	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
103690000538	beta subunit interaction interface [polypeptide binding]; other site
103690000539	Walker A motif; other site
103690000540	ATP binding site [chemical binding]; other site
103690000541	Walker B motif; other site
103690000542	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
103690000543	ATP synthase, F1 delta subunit; Region: ATP_synt_delta; TIGR01145
103690000544	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
103690000545	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
103690000546	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
103690000547	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
103690000548	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
103690000549	ATP synthase CF0 C subunit; Region: atpH; CHL00061
103690000550	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
103690000551	ATP synthase CF0 A subunit; Region: atpI; CHL00046
103690000552	ATP synthase I chain; Region: ATP_synt_I; pfam03899
103690000553	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690000554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000555	S-adenosylmethionine binding site [chemical binding]; other site
103690000556	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690000557	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690000558	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690000559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690000560	Homeodomain-like domain; Region: HTH_32; pfam13565
103690000561	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690000562	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690000563	phycobillisome linker protein; Region: apcE; CHL00091
103690000564	Phycobilisome protein; Region: Phycobilisome; cl08227
103690000565	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690000566	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690000567	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690000568	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690000569	Phycobilisome protein; Region: Phycobilisome; cl08227
103690000570	Phycobilisome protein; Region: Phycobilisome; cl08227
103690000571	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
103690000572	Uncharacterized conserved protein [Function unknown]; Region: COG2912
103690000573	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
103690000574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690000575	binding surface
103690000576	TPR motif; other site
103690000577	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
103690000578	hydrophobic ligand binding site; other site
103690000579	AAA ATPase domain; Region: AAA_16; pfam13191
103690000580	NACHT domain; Region: NACHT; pfam05729
103690000581	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690000582	structural tetrad; other site
103690000583	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690000584	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690000585	structural tetrad; other site
103690000586	WD40 repeats; Region: WD40; smart00320
103690000587	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
103690000588	B12 binding site [chemical binding]; other site
103690000589	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
103690000590	glycogen synthase; Provisional; Region: glgA; PRK00654
103690000591	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
103690000592	ADP-binding pocket [chemical binding]; other site
103690000593	homodimer interface [polypeptide binding]; other site
103690000594	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
103690000595	chorismate binding enzyme; Region: Chorismate_bind; cl10555
103690000596	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
103690000597	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690000598	O-succinylbenzoate synthase; Provisional; Region: PRK02714
103690000599	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
103690000600	active site
103690000601	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
103690000602	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
103690000603	acyl-activating enzyme (AAE) consensus motif; other site
103690000604	putative AMP binding site [chemical binding]; other site
103690000605	putative active site [active]
103690000606	putative CoA binding site [chemical binding]; other site
103690000607	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
103690000608	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
103690000609	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690000610	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690000611	tellurite resistance protein terB; Region: terB; cd07176
103690000612	putative metal binding site [ion binding]; other site
103690000613	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
103690000614	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
103690000615	NAD binding site [chemical binding]; other site
103690000616	substrate binding site [chemical binding]; other site
103690000617	homodimer interface [polypeptide binding]; other site
103690000618	active site
103690000619	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690000620	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
103690000621	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
103690000622	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
103690000623	Ligand binding site; other site
103690000624	Putative Catalytic site; other site
103690000625	DXD motif; other site
103690000626	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
103690000627	Ycf35; Provisional; Region: ycf35; CHL00193
103690000628	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
103690000629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4298
103690000630	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
103690000631	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
103690000632	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
103690000633	MutS domain III; Region: MutS_III; pfam05192
103690000634	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690000635	Walker A/P-loop; other site
103690000636	ATP binding site [chemical binding]; other site
103690000637	Q-loop/lid; other site
103690000638	ABC transporter signature motif; other site
103690000639	Walker B; other site
103690000640	D-loop; other site
103690000641	H-loop/switch region; other site
103690000642	Smr domain; Region: Smr; pfam01713
103690000643	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
103690000644	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
103690000645	active site
103690000646	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690000647	catalytic residues [active]
103690000648	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
103690000649	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
103690000650	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
103690000651	Predicted membrane protein [Function unknown]; Region: COG5305
103690000652	Aromatic ring-cleaving dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DodA; COG3805
103690000653	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
103690000654	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
103690000655	putative ligand binding site [chemical binding]; other site
103690000656	putative NAD binding site [chemical binding]; other site
103690000657	catalytic site [active]
103690000658	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690000659	Chain length determinant protein; Region: Wzz; pfam02706
103690000660	AAA domain; Region: AAA_31; pfam13614
103690000661	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690000662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
103690000663	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
103690000664	Protein of unknown function (DUF751); Region: DUF751; pfam05421
103690000665	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
103690000666	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
103690000667	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
103690000668	trimer interface [polypeptide binding]; other site
103690000669	active site
103690000670	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
103690000671	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
103690000672	adenylate kinase; Reviewed; Region: adk; PRK00279
103690000673	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
103690000674	AMP-binding site [chemical binding]; other site
103690000675	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
103690000676	ribonuclease PH; Reviewed; Region: rph; PRK00173
103690000677	Ribonuclease PH; Region: RNase_PH_bact; cd11362
103690000678	hexamer interface [polypeptide binding]; other site
103690000679	active site
103690000680	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
103690000681	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
103690000682	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
103690000683	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690000684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000685	active site
103690000686	phosphorylation site [posttranslational modification]
103690000687	intermolecular recognition site; other site
103690000688	dimerization interface [polypeptide binding]; other site
103690000689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690000690	DNA binding site [nucleotide binding]
103690000691	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690000692	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
103690000693	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690000694	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690000695	active site
103690000696	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
103690000697	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690000698	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
103690000699	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
103690000700	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690000701	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
103690000702	Walker A/P-loop; other site
103690000703	ATP binding site [chemical binding]; other site
103690000704	Q-loop/lid; other site
103690000705	ABC transporter signature motif; other site
103690000706	Walker B; other site
103690000707	D-loop; other site
103690000708	H-loop/switch region; other site
103690000709	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
103690000710	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
103690000711	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
103690000712	active site
103690000713	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
103690000714	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
103690000715	catalytic motif [active]
103690000716	Zn binding site [ion binding]; other site
103690000717	RibD C-terminal domain; Region: RibD_C; cl17279
103690000718	XisH protein; Region: XisH; pfam08814
103690000719	XisI protein; Region: XisI; pfam08869
103690000720	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
103690000721	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
103690000722	rod shape-determining protein MreC; Region: MreC; pfam04085
103690000723	rod shape-determining protein MreB; Provisional; Region: PRK13927
103690000724	MreB and similar proteins; Region: MreB_like; cd10225
103690000725	nucleotide binding site [chemical binding]; other site
103690000726	Mg binding site [ion binding]; other site
103690000727	putative protofilament interaction site [polypeptide binding]; other site
103690000728	RodZ interaction site [polypeptide binding]; other site
103690000729	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
103690000730	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
103690000731	dimer interface [polypeptide binding]; other site
103690000732	ssDNA binding site [nucleotide binding]; other site
103690000733	tetramer (dimer of dimers) interface [polypeptide binding]; other site
103690000734	Uncharacterized conserved protein [Function unknown]; Region: COG2968
103690000735	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
103690000736	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690000737	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
103690000738	AMIN domain; Region: AMIN; pfam11741
103690000739	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690000740	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690000741	active site
103690000742	metal binding site [ion binding]; metal-binding site
103690000743	AMIN domain; Region: AMIN; pfam11741
103690000744	AMIN domain; Region: AMIN; pfam11741
103690000745	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690000746	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690000747	active site
103690000748	metal binding site [ion binding]; metal-binding site
103690000749	glutamate racemase; Provisional; Region: PRK00865
103690000750	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
103690000751	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
103690000752	substrate binding pocket [chemical binding]; other site
103690000753	chain length determination region; other site
103690000754	substrate-Mg2+ binding site; other site
103690000755	catalytic residues [active]
103690000756	aspartate-rich region 1; other site
103690000757	active site lid residues [active]
103690000758	aspartate-rich region 2; other site
103690000759	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
103690000760	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
103690000761	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
103690000762	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
103690000763	hypothetical protein; Provisional; Region: PRK04323
103690000764	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
103690000765	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
103690000766	catalytic site [active]
103690000767	G-X2-G-X-G-K; other site
103690000768	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
103690000769	photosystem I reaction center subunit IX; Provisional; Region: PRK02733
103690000770	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
103690000771	UGMP family protein; Validated; Region: PRK09604
103690000772	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
103690000773	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690000774	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
103690000775	catalytic site [active]
103690000776	Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479
103690000777	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690000778	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690000779	Coenzyme A binding pocket [chemical binding]; other site
103690000780	Tic22-like family; Region: Tic22; cl04468
103690000781	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
103690000782	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690000783	S-adenosylmethionine binding site [chemical binding]; other site
103690000784	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
103690000785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690000786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690000787	dimer interface [polypeptide binding]; other site
103690000788	phosphorylation site [posttranslational modification]
103690000789	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
103690000790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690000791	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690000792	Coenzyme A binding pocket [chemical binding]; other site
103690000793	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
103690000794	Protein export membrane protein; Region: SecD_SecF; pfam02355
103690000795	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
103690000796	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
103690000797	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
103690000798	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
103690000799	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
103690000800	alpha subunit interface [polypeptide binding]; other site
103690000801	TPP binding site [chemical binding]; other site
103690000802	heterodimer interface [polypeptide binding]; other site
103690000803	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
103690000804	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690000805	putative active site [active]
103690000806	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
103690000807	Leucine-rich repeats; other site
103690000808	Leucine rich repeat; Region: LRR_8; pfam13855
103690000809	Substrate binding site [chemical binding]; other site
103690000810	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
103690000811	Leucine rich repeat; Region: LRR_8; pfam13855
103690000812	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
103690000813	Leucine rich repeat; Region: LRR_8; pfam13855
103690000814	Leucine-rich repeats; other site
103690000815	Substrate binding site [chemical binding]; other site
103690000816	Leucine rich repeat; Region: LRR_8; pfam13855
103690000817	Leucine rich repeat; Region: LRR_8; pfam13855
103690000818	Leucine rich repeat; Region: LRR_8; pfam13855
103690000819	Leucine rich repeat; Region: LRR_8; pfam13855
103690000820	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
103690000821	Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914
103690000822	G1 box; other site
103690000823	GTP/Mg2+ binding site [chemical binding]; other site
103690000824	G2 box; other site
103690000825	Switch I region; other site
103690000826	G3 box; other site
103690000827	Switch II region; other site
103690000828	G4 box; other site
103690000829	G5 box; other site
103690000830	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690000831	salt bridge; other site
103690000832	non-specific DNA binding site [nucleotide binding]; other site
103690000833	sequence-specific DNA binding site [nucleotide binding]; other site
103690000834	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
103690000835	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
103690000836	Walker A/P-loop; other site
103690000837	ATP binding site [chemical binding]; other site
103690000838	Q-loop/lid; other site
103690000839	ABC transporter signature motif; other site
103690000840	Walker B; other site
103690000841	D-loop; other site
103690000842	H-loop/switch region; other site
103690000843	TOBE-like domain; Region: TOBE_3; pfam12857
103690000844	Haemolytic domain; Region: Haemolytic; cl00506
103690000845	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
103690000846	geranylgeranyl reductase; Region: ChlP; TIGR02028
103690000847	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690000848	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690000849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000850	active site
103690000851	phosphorylation site [posttranslational modification]
103690000852	intermolecular recognition site; other site
103690000853	dimerization interface [polypeptide binding]; other site
103690000854	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690000855	DNA binding site [nucleotide binding]
103690000856	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
103690000857	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690000858	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
103690000859	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690000860	putative active site [active]
103690000861	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690000862	putative active site [active]
103690000863	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690000864	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690000865	motif II; other site
103690000866	30S ribosomal protein S1; Reviewed; Region: PRK07400
103690000867	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
103690000868	RNA binding site [nucleotide binding]; other site
103690000869	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
103690000870	RNA binding site [nucleotide binding]; other site
103690000871	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
103690000872	RNA binding site [nucleotide binding]; other site
103690000873	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
103690000874	photosystem II 47 kDa protein; Region: psbB; CHL00062
103690000875	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
103690000876	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
103690000877	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
103690000878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690000879	dimer interface [polypeptide binding]; other site
103690000880	conserved gate region; other site
103690000881	putative PBP binding loops; other site
103690000882	ABC-ATPase subunit interface; other site
103690000883	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
103690000884	RNA/DNA hybrid binding site [nucleotide binding]; other site
103690000885	active site
103690000886	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
103690000887	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
103690000888	active site
103690000889	Predicted membrane protein [Function unknown]; Region: COG2324
103690000890	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
103690000891	ribosomal protein L21; Region: rpl21; CHL00075
103690000892	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
103690000893	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
103690000894	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690000895	putative active site [active]
103690000896	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
103690000897	Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417
103690000898	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
103690000899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690000900	Walker A motif; other site
103690000901	ATP binding site [chemical binding]; other site
103690000902	Beta-lactamase; Region: Beta-lactamase; pfam00144
103690000903	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
103690000904	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
103690000905	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690000906	phosphopeptide binding site; other site
103690000907	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
103690000908	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690000909	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690000910	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690000911	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690000912	cytochrome c6; Provisional; Region: PRK13697
103690000913	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
103690000914	Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401
103690000915	Predicted membrane protein [Function unknown]; Region: COG1950
103690000916	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
103690000917	Family description; Region: UvrD_C_2; pfam13538
103690000918	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
103690000919	Trehalase; Region: Trehalase; cl17346
103690000920	Maltooligosyl trehalose synthase [Carbohydrate transport and metabolism]; Region: TreY; COG3280
103690000921	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
103690000922	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
103690000923	active site
103690000924	catalytic site [active]
103690000925	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
103690000926	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
103690000927	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
103690000928	catalytic site [active]
103690000929	active site
103690000930	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
103690000931	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
103690000932	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
103690000933	active site
103690000934	catalytic site [active]
103690000935	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467
103690000936	starch-binding site 2 [chemical binding]; other site
103690000937	starch-binding site 1 [chemical binding]; other site
103690000938	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
103690000939	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
103690000940	active site
103690000941	substrate binding site [chemical binding]; other site
103690000942	FMN binding site [chemical binding]; other site
103690000943	putative catalytic residues [active]
103690000944	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
103690000945	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
103690000946	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
103690000947	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
103690000948	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
103690000949	hinge; other site
103690000950	active site
103690000951	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
103690000952	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
103690000953	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
103690000954	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690000955	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
103690000956	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
103690000957	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690000958	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690000959	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690000960	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690000961	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
103690000962	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
103690000963	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
103690000964	Walker A/P-loop; other site
103690000965	ATP binding site [chemical binding]; other site
103690000966	Q-loop/lid; other site
103690000967	ABC transporter signature motif; other site
103690000968	Walker B; other site
103690000969	D-loop; other site
103690000970	H-loop/switch region; other site
103690000971	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
103690000972	mce related protein; Region: MCE; pfam02470
103690000973	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690000974	PAS fold; Region: PAS_3; pfam08447
103690000975	putative active site [active]
103690000976	heme pocket [chemical binding]; other site
103690000977	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690000978	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690000979	dimer interface [polypeptide binding]; other site
103690000980	phosphorylation site [posttranslational modification]
103690000981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690000982	ATP binding site [chemical binding]; other site
103690000983	Mg2+ binding site [ion binding]; other site
103690000984	G-X-G motif; other site
103690000985	Response regulator receiver domain; Region: Response_reg; pfam00072
103690000986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690000987	active site
103690000988	phosphorylation site [posttranslational modification]
103690000989	intermolecular recognition site; other site
103690000990	dimerization interface [polypeptide binding]; other site
103690000991	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
103690000992	DHH family; Region: DHH; pfam01368
103690000993	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
103690000994	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
103690000995	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000996	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690000997	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690000998	Transcriptional regulator [Transcription]; Region: LytR; COG1316
103690000999	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
103690001000	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
103690001001	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
103690001002	Substrate binding site; other site
103690001003	Cupin domain; Region: Cupin_2; cl17218
103690001004	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
103690001005	ABC1 family; Region: ABC1; cl17513
103690001006	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
103690001007	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690001008	Walker A/P-loop; other site
103690001009	ATP binding site [chemical binding]; other site
103690001010	Q-loop/lid; other site
103690001011	ABC transporter signature motif; other site
103690001012	Walker B; other site
103690001013	D-loop; other site
103690001014	H-loop/switch region; other site
103690001015	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
103690001016	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
103690001017	Double zinc ribbon; Region: DZR; pfam12773
103690001018	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690001019	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690001020	active site
103690001021	substrate binding site [chemical binding]; other site
103690001022	ATP binding site [chemical binding]; other site
103690001023	activation loop (A-loop); other site
103690001024	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690001025	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690001026	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
103690001027	ArsC family; Region: ArsC; pfam03960
103690001028	catalytic residue [active]
103690001029	Predicted integral membrane protein [Function unknown]; Region: COG0392
103690001030	hypothetical protein; Provisional; Region: PRK04194
103690001031	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
103690001032	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
103690001033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690001034	ATP binding site [chemical binding]; other site
103690001035	putative Mg++ binding site [ion binding]; other site
103690001036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690001037	nucleotide binding region [chemical binding]; other site
103690001038	ATP-binding site [chemical binding]; other site
103690001039	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
103690001040	HRDC domain; Region: HRDC; pfam00570
103690001041	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
103690001042	DNA binding residues [nucleotide binding]
103690001043	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
103690001044	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690001045	putative active site [active]
103690001046	putative metal binding site [ion binding]; other site
103690001047	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690001048	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690001049	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690001050	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
103690001051	nudix motif; other site
103690001052	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
103690001053	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
103690001054	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
103690001055	homodimer interface [polypeptide binding]; other site
103690001056	NADP binding site [chemical binding]; other site
103690001057	substrate binding site [chemical binding]; other site
103690001058	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
103690001059	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
103690001060	substrate binding pocket [chemical binding]; other site
103690001061	chain length determination region; other site
103690001062	substrate-Mg2+ binding site; other site
103690001063	catalytic residues [active]
103690001064	aspartate-rich region 1; other site
103690001065	active site lid residues [active]
103690001066	aspartate-rich region 2; other site
103690001067	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
103690001068	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
103690001069	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
103690001070	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
103690001071	active site
103690001072	hydrophilic channel; other site
103690001073	dimerization interface [polypeptide binding]; other site
103690001074	catalytic residues [active]
103690001075	active site lid [active]
103690001076	PAS domain S-box; Region: sensory_box; TIGR00229
103690001077	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690001078	putative active site [active]
103690001079	heme pocket [chemical binding]; other site
103690001080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690001081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690001082	metal binding site [ion binding]; metal-binding site
103690001083	active site
103690001084	I-site; other site
103690001085	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690001086	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
103690001087	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690001088	catalytic core [active]
103690001089	citrate synthase; Provisional; Region: PRK14036
103690001090	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
103690001091	dimer interface [polypeptide binding]; other site
103690001092	active site
103690001093	citrylCoA binding site [chemical binding]; other site
103690001094	oxalacetate/citrate binding site [chemical binding]; other site
103690001095	coenzyme A binding site [chemical binding]; other site
103690001096	catalytic triad [active]
103690001097	NADH dehydrogenase subunit 1; Region: ndhA; CHL00032
103690001098	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
103690001099	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
103690001100	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
103690001101	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
103690001102	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
103690001103	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
103690001104	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
103690001105	ATP-NAD kinase; Region: NAD_kinase; pfam01513
103690001106	Putative hemolysin [General function prediction only]; Region: COG3176
103690001107	Predicted membrane protein [Function unknown]; Region: COG5305
103690001108	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
103690001109	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
103690001110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
103690001111	Uncharacterized conserved protein [Function unknown]; Region: COG1432
103690001112	LabA_like proteins; Region: LabA; cd10911
103690001113	putative metal binding site [ion binding]; other site
103690001114	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
103690001115	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
103690001116	active site
103690001117	HIGH motif; other site
103690001118	KMSKS motif; other site
103690001119	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
103690001120	anticodon binding site; other site
103690001121	tRNA binding surface [nucleotide binding]; other site
103690001122	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690001123	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
103690001124	putative acyl-acceptor binding pocket; other site
103690001125	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
103690001126	multifunctional aminopeptidase A; Provisional; Region: PRK00913
103690001127	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
103690001128	interface (dimer of trimers) [polypeptide binding]; other site
103690001129	Substrate-binding/catalytic site; other site
103690001130	Zn-binding sites [ion binding]; other site
103690001131	putative phosphate acyltransferase; Provisional; Region: PRK05331
103690001132	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
103690001133	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
103690001134	dimer interface [polypeptide binding]; other site
103690001135	active site
103690001136	CoA binding pocket [chemical binding]; other site
103690001137	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
103690001138	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
103690001139	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690001140	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
103690001141	putative acyl-acceptor binding pocket; other site
103690001142	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690001143	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
103690001144	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690001145	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690001146	putative active site [active]
103690001147	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
103690001148	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690001149	HSP70 interaction site [polypeptide binding]; other site
103690001150	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690001151	TPR repeat; Region: TPR_11; pfam13414
103690001152	binding surface
103690001153	TPR motif; other site
103690001154	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001155	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690001156	structural tetrad; other site
103690001157	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690001158	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690001159	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690001160	phosphodiesterase YaeI; Provisional; Region: PRK11340
103690001161	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
103690001162	putative active site [active]
103690001163	putative metal binding site [ion binding]; other site
103690001164	phosphodiesterase YaeI; Provisional; Region: PRK11340
103690001165	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
103690001166	putative active site [active]
103690001167	putative metal binding site [ion binding]; other site
103690001168	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
103690001169	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
103690001170	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
103690001171	TrkA-N domain; Region: TrkA_N; pfam02254
103690001172	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
103690001173	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
103690001174	heme bL binding site [chemical binding]; other site
103690001175	interchain domain interface [polypeptide binding]; other site
103690001176	intrachain domain interface; other site
103690001177	heme bH binding site [chemical binding]; other site
103690001178	Qo binding site; other site
103690001179	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
103690001180	PGAP1-like protein; Region: PGAP1; pfam07819
103690001181	Cytochrome c; Region: Cytochrom_C; cl11414
103690001182	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
103690001183	plastocyanin; Provisional; Region: PRK02710
103690001184	cytochrome c-550; Provisional; Region: psbV; PRK13618
103690001185	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
103690001186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690001187	dimer interface [polypeptide binding]; other site
103690001188	conserved gate region; other site
103690001189	putative PBP binding loops; other site
103690001190	ABC-ATPase subunit interface; other site
103690001191	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
103690001192	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
103690001193	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
103690001194	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690001195	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690001196	AAA domain; Region: AAA_18; pfam13238
103690001197	Walker A motif; other site
103690001198	ATP binding site [chemical binding]; other site
103690001199	Walker B motif; other site
103690001200	arginine finger; other site
103690001201	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690001202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690001203	active site
103690001204	phosphorylation site [posttranslational modification]
103690001205	intermolecular recognition site; other site
103690001206	dimerization interface [polypeptide binding]; other site
103690001207	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
103690001208	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
103690001209	Catalytic site; other site
103690001210	proline aminopeptidase P II; Provisional; Region: PRK10879
103690001211	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
103690001212	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
103690001213	active site
103690001214	Family description; Region: VCBS; pfam13517
103690001215	Family description; Region: VCBS; pfam13517
103690001216	Family description; Region: VCBS; pfam13517
103690001217	Family description; Region: VCBS; pfam13517
103690001218	Family description; Region: VCBS; pfam13517
103690001219	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
103690001220	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
103690001221	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
103690001222	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
103690001223	glutamine binding [chemical binding]; other site
103690001224	catalytic triad [active]
103690001225	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
103690001226	metal-binding heat shock protein; Provisional; Region: PRK00016
103690001227	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
103690001228	This domain is found in peptide chain release factors; Region: PCRF; smart00937
103690001229	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
103690001230	RF-1 domain; Region: RF-1; pfam00472
103690001231	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690001232	Calx-beta domain; Region: Calx-beta; cl02522
103690001233	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690001234	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690001235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
103690001236	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
103690001237	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
103690001238	putative active site [active]
103690001239	catalytic site [active]
103690001240	putative metal binding site [ion binding]; other site
103690001241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
103690001242	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690001243	Lamin Tail Domain; Region: LTD; pfam00932
103690001244	Lamin Tail Domain; Region: LTD; pfam00932
103690001245	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
103690001246	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
103690001247	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
103690001248	generic binding surface II; other site
103690001249	generic binding surface I; other site
103690001250	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
103690001251	putative active site [active]
103690001252	putative catalytic site [active]
103690001253	putative Mg binding site IVb [ion binding]; other site
103690001254	putative phosphate binding site [ion binding]; other site
103690001255	putative DNA binding site [nucleotide binding]; other site
103690001256	putative Mg binding site IVa [ion binding]; other site
103690001257	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690001258	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
103690001259	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690001260	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690001261	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
103690001262	DNA binding residues [nucleotide binding]
103690001263	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
103690001264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690001265	Walker A motif; other site
103690001266	ATP binding site [chemical binding]; other site
103690001267	Walker B motif; other site
103690001268	arginine finger; other site
103690001269	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
103690001270	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
103690001271	metal ion-dependent adhesion site (MIDAS); other site
103690001272	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690001273	putative active site [active]
103690001274	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
103690001275	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
103690001276	dimerization interface [polypeptide binding]; other site
103690001277	active site
103690001278	metal binding site [ion binding]; metal-binding site
103690001279	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
103690001280	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690001281	Caspase domain; Region: Peptidase_C14; pfam00656
103690001282	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001283	structural tetrad; other site
103690001284	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690001285	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001286	structural tetrad; other site
103690001287	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690001288	Caspase domain; Region: Peptidase_C14; pfam00656
103690001289	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001290	structural tetrad; other site
103690001291	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690001292	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001293	structural tetrad; other site
103690001294	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
103690001295	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
103690001296	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
103690001297	putative dimer interface [polypeptide binding]; other site
103690001298	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
103690001299	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
103690001300	active site
103690001301	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
103690001302	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690001303	motif II; other site
103690001304	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
103690001305	active site
103690001306	dimerization interface [polypeptide binding]; other site
103690001307	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
103690001308	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
103690001309	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690001310	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
103690001311	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
103690001312	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690001313	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690001314	ligand binding site [chemical binding]; other site
103690001315	flexible hinge region; other site
103690001316	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
103690001317	putative switch regulator; other site
103690001318	non-specific DNA interactions [nucleotide binding]; other site
103690001319	DNA binding site [nucleotide binding]
103690001320	sequence specific DNA binding site [nucleotide binding]; other site
103690001321	putative cAMP binding site [chemical binding]; other site
103690001322	Predicted membrane protein [Function unknown]; Region: COG4241
103690001323	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
103690001324	active site pocket [active]
103690001325	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
103690001326	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
103690001327	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690001328	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
103690001329	active site
103690001330	catalytic tetrad [active]
103690001331	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
103690001332	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
103690001333	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
103690001334	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690001335	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690001336	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690001337	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
103690001338	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
103690001339	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
103690001340	substrate binding pocket [chemical binding]; other site
103690001341	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
103690001342	B12 binding site [chemical binding]; other site
103690001343	cobalt ligand [ion binding]; other site
103690001344	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
103690001345	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
103690001346	Domain of unknown function DUF21; Region: DUF21; pfam01595
103690001347	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
103690001348	Double zinc ribbon; Region: DZR; pfam12773
103690001349	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
103690001350	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
103690001351	dimer interface [polypeptide binding]; other site
103690001352	tetramer interface [polypeptide binding]; other site
103690001353	PYR/PP interface [polypeptide binding]; other site
103690001354	TPP binding site [chemical binding]; other site
103690001355	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
103690001356	TPP-binding site; other site
103690001357	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
103690001358	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690001359	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690001360	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690001361	Hexamer interface [polypeptide binding]; other site
103690001362	Hexagonal pore residue; other site
103690001363	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690001364	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690001365	Hexamer interface [polypeptide binding]; other site
103690001366	Hexagonal pore residue; other site
103690001367	NIL domain; Region: NIL; pfam09383
103690001368	sulfate transport protein; Provisional; Region: cysT; CHL00187
103690001369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690001370	dimer interface [polypeptide binding]; other site
103690001371	conserved gate region; other site
103690001372	putative PBP binding loops; other site
103690001373	ABC-ATPase subunit interface; other site
103690001374	sulfate transport protein; Provisional; Region: cysT; CHL00187
103690001375	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690001376	dimer interface [polypeptide binding]; other site
103690001377	conserved gate region; other site
103690001378	putative PBP binding loops; other site
103690001379	ABC-ATPase subunit interface; other site
103690001380	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
103690001381	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
103690001382	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690001383	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690001384	active site
103690001385	ATP binding site [chemical binding]; other site
103690001386	substrate binding site [chemical binding]; other site
103690001387	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
103690001388	activation loop (A-loop); other site
103690001389	activation loop (A-loop); other site
103690001390	AAA ATPase domain; Region: AAA_16; pfam13191
103690001391	Predicted ATPase [General function prediction only]; Region: COG3899
103690001392	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690001393	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690001394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690001395	dimer interface [polypeptide binding]; other site
103690001396	phosphorylation site [posttranslational modification]
103690001397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690001398	ATP binding site [chemical binding]; other site
103690001399	Mg2+ binding site [ion binding]; other site
103690001400	G-X-G motif; other site
103690001401	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
103690001402	FAD binding domain; Region: FAD_binding_4; pfam01565
103690001403	Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265
103690001404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690001405	S-adenosylmethionine binding site [chemical binding]; other site
103690001406	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
103690001407	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
103690001408	putative active site [active]
103690001409	putative dimer interface [polypeptide binding]; other site
103690001410	anthranilate synthase component I; Provisional; Region: PRK13565
103690001411	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
103690001412	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
103690001413	PsaD; Region: PsaD; pfam02531
103690001414	Predicted sensor protein/domain [Signal transduction mechanisms]; Region: COG4250
103690001415	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690001416	GAF domain; Region: GAF; pfam01590
103690001417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690001418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690001419	dimer interface [polypeptide binding]; other site
103690001420	phosphorylation site [posttranslational modification]
103690001421	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690001422	ATP binding site [chemical binding]; other site
103690001423	Mg2+ binding site [ion binding]; other site
103690001424	G-X-G motif; other site
103690001425	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
103690001426	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
103690001427	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
103690001428	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
103690001429	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
103690001430	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
103690001431	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
103690001432	active site
103690001433	dimer interface [polypeptide binding]; other site
103690001434	motif 1; other site
103690001435	motif 2; other site
103690001436	motif 3; other site
103690001437	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
103690001438	anticodon binding site; other site
103690001439	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
103690001440	AAA ATPase domain; Region: AAA_16; pfam13191
103690001441	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
103690001442	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
103690001443	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
103690001444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690001445	TPR repeat; Region: TPR_11; pfam13414
103690001446	binding surface
103690001447	TPR motif; other site
103690001448	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690001449	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690001450	active site
103690001451	ATP binding site [chemical binding]; other site
103690001452	substrate binding site [chemical binding]; other site
103690001453	activation loop (A-loop); other site
103690001454	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
103690001455	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
103690001456	putative ligand binding site [chemical binding]; other site
103690001457	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
103690001458	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
103690001459	DNA binding residues [nucleotide binding]
103690001460	drug binding residues [chemical binding]; other site
103690001461	dimer interface [polypeptide binding]; other site
103690001462	Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978
103690001463	homoserine kinase; Provisional; Region: PRK01212
103690001464	Intermediate filament protein; Region: Filament; pfam00038
103690001465	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
103690001466	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690001467	2TM domain; Region: 2TM; pfam13239
103690001468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
103690001469	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
103690001470	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
103690001471	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
103690001472	NADP binding site [chemical binding]; other site
103690001473	substrate binding site [chemical binding]; other site
103690001474	active site
103690001475	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690001476	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690001477	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
103690001478	substrate binding pocket [chemical binding]; other site
103690001479	dimerization interface [polypeptide binding]; other site
103690001480	Protein kinase domain; Region: Pkinase; pfam00069
103690001481	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690001482	active site
103690001483	ATP binding site [chemical binding]; other site
103690001484	substrate binding site [chemical binding]; other site
103690001485	substrate binding site [chemical binding]; other site
103690001486	activation loop (A-loop); other site
103690001487	activation loop (A-loop); other site
103690001488	AAA ATPase domain; Region: AAA_16; pfam13191
103690001489	Predicted ATPase [General function prediction only]; Region: COG3899
103690001490	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690001491	GAF domain; Region: GAF; pfam01590
103690001492	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690001493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690001494	ATP binding site [chemical binding]; other site
103690001495	Mg2+ binding site [ion binding]; other site
103690001496	G-X-G motif; other site
103690001497	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
103690001498	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690001499	FeS/SAM binding site; other site
103690001500	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690001501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690001502	active site
103690001503	phosphorylation site [posttranslational modification]
103690001504	intermolecular recognition site; other site
103690001505	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690001506	CHASE2 domain; Region: CHASE2; pfam05226
103690001507	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
103690001508	ATP binding site [chemical binding]; other site
103690001509	G-X-G motif; other site
103690001510	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690001511	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690001512	TPR repeat; Region: TPR_11; pfam13414
103690001513	PPP5 TPR repeat region; Region: PPP5; pfam08321
103690001514	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690001515	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690001516	Homeodomain-like domain; Region: HTH_23; cl17451
103690001517	Winged helix-turn helix; Region: HTH_29; pfam13551
103690001518	Homeodomain-like domain; Region: HTH_32; pfam13565
103690001519	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
103690001520	calcium binding site 1 [ion binding]; other site
103690001521	active site
103690001522	catalytic triad [active]
103690001523	calcium binding site 2 [ion binding]; other site
103690001524	calcium binding site 3 [ion binding]; other site
103690001525	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
103690001526	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
103690001527	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690001528	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690001529	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690001530	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690001531	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690001532	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690001533	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690001534	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cd00044
103690001535	catalytic site [active]
103690001536	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690001537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690001538	putative substrate translocation pore; other site
103690001539	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
103690001540	MarR family; Region: MarR; pfam01047
103690001541	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
103690001542	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
103690001543	active site
103690001544	metal binding site [ion binding]; metal-binding site
103690001545	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
103690001546	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
103690001547	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690001548	catalytic residue [active]
103690001549	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
103690001550	RuvA N terminal domain; Region: RuvA_N; pfam01330
103690001551	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
103690001552	sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485
103690001553	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
103690001554	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
103690001555	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
103690001556	Nucleoside recognition; Region: Gate; pfam07670
103690001557	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
103690001558	cobalamin synthase; Reviewed; Region: cobS; PRK00235
103690001559	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09636
103690001560	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
103690001561	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
103690001562	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
103690001563	active site residue [active]
103690001564	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690001565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690001566	S-adenosylmethionine binding site [chemical binding]; other site
103690001567	putative acyl-acceptor binding pocket; other site
103690001568	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690001569	Phosphate acyltransferases; Region: PlsC; smart00563
103690001570	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
103690001571	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690001572	ABC-ATPase subunit  interface; other site
103690001573	dimer interface [polypeptide binding]; other site
103690001574	putative PBP binding regions; other site
103690001575	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
103690001576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690001577	ABC-ATPase subunit  interface; other site
103690001578	dimer interface [polypeptide binding]; other site
103690001579	putative PBP binding regions; other site
103690001580	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690001581	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
103690001582	siderophore binding site; other site
103690001583	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
103690001584	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
103690001585	Walker A/P-loop; other site
103690001586	ATP binding site [chemical binding]; other site
103690001587	Q-loop/lid; other site
103690001588	ABC transporter signature motif; other site
103690001589	Walker B; other site
103690001590	D-loop; other site
103690001591	H-loop/switch region; other site
103690001592	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
103690001593	IucA / IucC family; Region: IucA_IucC; pfam04183
103690001594	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
103690001595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690001596	Major Facilitator Superfamily; Region: MFS_1; pfam07690
103690001597	putative substrate translocation pore; other site
103690001598	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
103690001599	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690001600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
103690001601	Siderophore biosynthesis protein domain; Region: AlcB; smart01006
103690001602	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
103690001603	IucA / IucC family; Region: IucA_IucC; pfam04183
103690001604	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
103690001605	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
103690001606	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690001607	catalytic residue [active]
103690001608	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
103690001609	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
103690001610	inhibitor-cofactor binding pocket; inhibition site
103690001611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690001612	catalytic residue [active]
103690001613	AMIN domain; Region: AMIN; pfam11741
103690001614	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690001615	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690001616	N-terminal plug; other site
103690001617	ligand-binding site [chemical binding]; other site
103690001618	Uncharacterized small protein [Function unknown]; Region: COG2886
103690001619	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
103690001620	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
103690001621	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
103690001622	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
103690001623	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
103690001624	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
103690001625	trimer interface [polypeptide binding]; other site
103690001626	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
103690001627	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
103690001628	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
103690001629	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
103690001630	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
103690001631	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
103690001632	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
103690001633	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690001634	catalytic residue [active]
103690001635	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
103690001636	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
103690001637	substrate binding site [chemical binding]; other site
103690001638	active site
103690001639	catalytic residues [active]
103690001640	heterodimer interface [polypeptide binding]; other site
103690001641	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
103690001642	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
103690001643	putative NAD(P) binding site [chemical binding]; other site
103690001644	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
103690001645	active site
103690001646	ribulose/triose binding site [chemical binding]; other site
103690001647	phosphate binding site [ion binding]; other site
103690001648	substrate (anthranilate) binding pocket [chemical binding]; other site
103690001649	product (indole) binding pocket [chemical binding]; other site
103690001650	anthranilate synthase, alpha proteobacterial clade; Region: TrpE-clade3; TIGR01815
103690001651	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
103690001652	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
103690001653	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
103690001654	glutamine binding [chemical binding]; other site
103690001655	catalytic triad [active]
103690001656	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
103690001657	Dehydroquinate synthase (DHQS)-like. DHQS catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS-like2; cd08198
103690001658	active site
103690001659	metal binding site [ion binding]; metal-binding site
103690001660	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
103690001661	arogenate dehydrogenase; Region: PLN02256
103690001662	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382
103690001663	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690001664	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
103690001665	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
103690001666	active site
103690001667	Uncharacterized conserved protein [Function unknown]; Region: COG3391
103690001668	NHL repeat; Region: NHL; pfam01436
103690001669	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
103690001670	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
103690001671	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
103690001672	NAD binding site [chemical binding]; other site
103690001673	Phe binding site; other site
103690001674	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
103690001675	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
103690001676	PYR/PP interface [polypeptide binding]; other site
103690001677	dimer interface [polypeptide binding]; other site
103690001678	TPP binding site [chemical binding]; other site
103690001679	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
103690001680	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
103690001681	TPP-binding site [chemical binding]; other site
103690001682	PAS domain; Region: PAS_9; pfam13426
103690001683	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690001684	putative active site [active]
103690001685	heme pocket [chemical binding]; other site
103690001686	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690001687	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690001688	putative active site [active]
103690001689	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690001690	heme pocket [chemical binding]; other site
103690001691	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690001692	dimer interface [polypeptide binding]; other site
103690001693	phosphorylation site [posttranslational modification]
103690001694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690001695	ATP binding site [chemical binding]; other site
103690001696	Mg2+ binding site [ion binding]; other site
103690001697	G-X-G motif; other site
103690001698	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690001699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690001700	active site
103690001701	phosphorylation site [posttranslational modification]
103690001702	intermolecular recognition site; other site
103690001703	dimerization interface [polypeptide binding]; other site
103690001704	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690001705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690001706	short chain dehydrogenase; Provisional; Region: PRK07109
103690001707	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
103690001708	putative NAD(P) binding site [chemical binding]; other site
103690001709	active site
103690001710	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
103690001711	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
103690001712	active site
103690001713	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690001714	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690001715	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
103690001716	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
103690001717	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690001718	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690001719	active site
103690001720	ATP binding site [chemical binding]; other site
103690001721	substrate binding site [chemical binding]; other site
103690001722	activation loop (A-loop); other site
103690001723	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690001724	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001725	structural tetrad; other site
103690001726	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
103690001727	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690001728	Walker A/P-loop; other site
103690001729	ATP binding site [chemical binding]; other site
103690001730	Q-loop/lid; other site
103690001731	ABC transporter signature motif; other site
103690001732	Walker B; other site
103690001733	D-loop; other site
103690001734	H-loop/switch region; other site
103690001735	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
103690001736	TrkA-N domain; Region: TrkA_N; pfam02254
103690001737	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
103690001738	TrkA-N domain; Region: TrkA_N; pfam02254
103690001739	DNA gyrase subunit A; Validated; Region: PRK05560
103690001740	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
103690001741	CAP-like domain; other site
103690001742	active site
103690001743	primary dimer interface [polypeptide binding]; other site
103690001744	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690001745	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690001746	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690001747	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690001748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690001749	active site
103690001750	phosphorylation site [posttranslational modification]
103690001751	intermolecular recognition site; other site
103690001752	dimerization interface [polypeptide binding]; other site
103690001753	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690001754	binding surface
103690001755	TPR motif; other site
103690001756	TPR repeat; Region: TPR_11; pfam13414
103690001757	TPR repeat; Region: TPR_11; pfam13414
103690001758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690001759	binding surface
103690001760	TPR motif; other site
103690001761	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690001762	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
103690001763	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690001764	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690001765	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
103690001766	FtsX-like permease family; Region: FtsX; pfam02687
103690001767	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
103690001768	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690001769	Walker A/P-loop; other site
103690001770	ATP binding site [chemical binding]; other site
103690001771	Q-loop/lid; other site
103690001772	ABC transporter signature motif; other site
103690001773	Walker B; other site
103690001774	D-loop; other site
103690001775	H-loop/switch region; other site
103690001776	ferrochelatase; Region: PLN02449
103690001777	Phycobilisome protein; Region: Phycobilisome; cl08227
103690001778	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690001779	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690001780	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690001781	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690001782	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
103690001783	FtsX-like permease family; Region: FtsX; pfam02687
103690001784	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
103690001785	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
103690001786	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
103690001787	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
103690001788	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
103690001789	active site
103690001790	SAM binding site [chemical binding]; other site
103690001791	homodimer interface [polypeptide binding]; other site
103690001792	Divergent AAA domain; Region: AAA_4; pfam04326
103690001793	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
103690001794	active site
103690001795	SAM binding site [chemical binding]; other site
103690001796	homodimer interface [polypeptide binding]; other site
103690001797	precorrin-3B synthase; Region: CobG; TIGR02435
103690001798	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690001799	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690001800	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
103690001801	Precorrin-8X methylmutase; Region: CbiC; pfam02570
103690001802	ChaB; Region: ChaB; pfam06150
103690001803	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
103690001804	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
103690001805	dimerization interface [polypeptide binding]; other site
103690001806	DPS ferroxidase diiron center [ion binding]; other site
103690001807	ion pore; other site
103690001808	PHP-associated; Region: PHP_C; pfam13263
103690001809	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
103690001810	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
103690001811	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
103690001812	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
103690001813	Family of unknown function (DUF490); Region: DUF490; pfam04357
103690001814	Family of unknown function (DUF490); Region: DUF490; pfam04357
103690001815	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
103690001816	AAA-like domain; Region: AAA_10; pfam12846
103690001817	Microsomal signal peptidase 25 kDa subunit (SPC25); Region: SPC25; pfam06703
103690001818	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
103690001819	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
103690001820	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
103690001821	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
103690001822	putative NAD(P) binding site [chemical binding]; other site
103690001823	homodimer interface [polypeptide binding]; other site
103690001824	homotetramer interface [polypeptide binding]; other site
103690001825	active site
103690001826	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
103690001827	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
103690001828	active site
103690001829	AAA ATPase domain; Region: AAA_16; pfam13191
103690001830	Walker A motif; other site
103690001831	ATP binding site [chemical binding]; other site
103690001832	WD domain, G-beta repeat; Region: WD40; pfam00400
103690001833	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001834	structural tetrad; other site
103690001835	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690001836	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690001837	structural tetrad; other site
103690001838	WD40 repeats; Region: WD40; smart00320
103690001839	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
103690001840	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690001841	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
103690001842	putative NAD(P) binding site [chemical binding]; other site
103690001843	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
103690001844	hydrophobic ligand binding site; other site
103690001845	GTP-binding protein Der; Reviewed; Region: PRK00093
103690001846	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
103690001847	G1 box; other site
103690001848	GTP/Mg2+ binding site [chemical binding]; other site
103690001849	Switch I region; other site
103690001850	G2 box; other site
103690001851	Switch II region; other site
103690001852	G3 box; other site
103690001853	G4 box; other site
103690001854	G5 box; other site
103690001855	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
103690001856	G1 box; other site
103690001857	GTP/Mg2+ binding site [chemical binding]; other site
103690001858	Switch I region; other site
103690001859	G2 box; other site
103690001860	G3 box; other site
103690001861	Switch II region; other site
103690001862	G4 box; other site
103690001863	G5 box; other site
103690001864	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
103690001865	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
103690001866	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
103690001867	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
103690001868	catalytic residue [active]
103690001869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
103690001870	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
103690001871	pyrroline-5-carboxylate reductase; Region: PLN02688
103690001872	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
103690001873	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690001874	ATP binding site [chemical binding]; other site
103690001875	putative Mg++ binding site [ion binding]; other site
103690001876	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690001877	nucleotide binding region [chemical binding]; other site
103690001878	ATP-binding site [chemical binding]; other site
103690001879	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
103690001880	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
103690001881	membrane protein; Provisional; Region: PRK14419
103690001882	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690001883	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690001884	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690001885	Nucleotide binding site [chemical binding]; other site
103690001886	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
103690001887	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
103690001888	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
103690001889	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
103690001890	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
103690001891	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
103690001892	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
103690001893	inhibitor-cofactor binding pocket; inhibition site
103690001894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690001895	catalytic residue [active]
103690001896	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
103690001897	HsdM N-terminal domain; Region: HsdM_N; pfam12161
103690001898	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690001899	Fic family protein [Function unknown]; Region: COG3177
103690001900	Fic family protein [Function unknown]; Region: COG3177
103690001901	Fic/DOC family; Region: Fic; pfam02661
103690001902	Fic/DOC family; Region: Fic; cl00960
103690001903	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
103690001904	putative active site [active]
103690001905	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690001906	putative active site [active]
103690001907	Predicted ATPase [General function prediction only]; Region: COG4637
103690001908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690001909	Walker A/P-loop; other site
103690001910	ATP binding site [chemical binding]; other site
103690001911	Q-loop/lid; other site
103690001912	ABC transporter signature motif; other site
103690001913	Walker B; other site
103690001914	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
103690001915	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
103690001916	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
103690001917	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
103690001918	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
103690001919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690001920	putative Mg++ binding site [ion binding]; other site
103690001921	Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008
103690001922	Uncharacterized metal-binding protein [General function prediction only]; Region: COG2389
103690001923	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
103690001924	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
103690001925	homodimer interface [polypeptide binding]; other site
103690001926	metal binding site [ion binding]; metal-binding site
103690001927	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
103690001928	homodimer interface [polypeptide binding]; other site
103690001929	active site
103690001930	putative chemical substrate binding site [chemical binding]; other site
103690001931	metal binding site [ion binding]; metal-binding site
103690001932	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
103690001933	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690001934	putative catalytic residue [active]
103690001935	putative high light inducible protein; Region: PHA02337
103690001936	Predicted alternative thymidylate synthase [Nucleotide transport and metabolism]; Region: THY1; COG1351
103690001937	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
103690001938	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
103690001939	putative substrate binding site [chemical binding]; other site
103690001940	putative ATP binding site [chemical binding]; other site
103690001941	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
103690001942	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
103690001943	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
103690001944	putative active site [active]
103690001945	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
103690001946	putative active site [active]
103690001947	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
103690001948	active site
103690001949	SAM binding site [chemical binding]; other site
103690001950	homodimer interface [polypeptide binding]; other site
103690001951	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
103690001952	Response regulator receiver domain; Region: Response_reg; pfam00072
103690001953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690001954	active site
103690001955	phosphorylation site [posttranslational modification]
103690001956	intermolecular recognition site; other site
103690001957	dimerization interface [polypeptide binding]; other site
103690001958	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
103690001959	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
103690001960	RNA binding surface [nucleotide binding]; other site
103690001961	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
103690001962	active site
103690001963	Phycobilisome protein; Region: Phycobilisome; cl08227
103690001964	Phycobilisome protein; Region: Phycobilisome; cl08227
103690001965	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001966	CpcD/allophycocyanin linker domain; Region: CpcD; smart01094
103690001967	HEAT repeats; Region: HEAT_2; pfam13646
103690001968	HEAT repeats; Region: HEAT_2; pfam13646
103690001969	HEAT repeats; Region: HEAT_2; pfam13646
103690001970	phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339
103690001971	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
103690001972	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001973	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
103690001974	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
103690001975	HEAT repeats; Region: HEAT_2; pfam13646
103690001976	HEAT repeats; Region: HEAT_2; pfam13646
103690001977	HEAT repeats; Region: HEAT_2; pfam13646
103690001978	HEAT repeats; Region: HEAT_2; pfam13646
103690001979	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001980	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001981	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001982	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
103690001983	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
103690001984	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690001985	S-adenosylmethionine binding site [chemical binding]; other site
103690001986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
103690001987	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
103690001988	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
103690001989	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
103690001990	Glutamate binding site [chemical binding]; other site
103690001991	homodimer interface [polypeptide binding]; other site
103690001992	NAD binding site [chemical binding]; other site
103690001993	catalytic residues [active]
103690001994	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690001995	Coenzyme A binding pocket [chemical binding]; other site
103690001996	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690001997	GAF domain; Region: GAF; pfam01590
103690001998	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690001999	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002000	putative active site [active]
103690002001	heme pocket [chemical binding]; other site
103690002002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002003	dimer interface [polypeptide binding]; other site
103690002004	phosphorylation site [posttranslational modification]
103690002005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002006	ATP binding site [chemical binding]; other site
103690002007	Mg2+ binding site [ion binding]; other site
103690002008	G-X-G motif; other site
103690002009	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
103690002010	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
103690002011	cobalamin binding residues [chemical binding]; other site
103690002012	putative BtuC binding residues; other site
103690002013	dimer interface [polypeptide binding]; other site
103690002014	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
103690002015	pseudouridine synthase; Region: TIGR00093
103690002016	probable active site [active]
103690002017	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
103690002018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002019	putative active site [active]
103690002020	heme pocket [chemical binding]; other site
103690002021	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002022	dimer interface [polypeptide binding]; other site
103690002023	phosphorylation site [posttranslational modification]
103690002024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002025	ATP binding site [chemical binding]; other site
103690002026	Mg2+ binding site [ion binding]; other site
103690002027	G-X-G motif; other site
103690002028	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
103690002029	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
103690002030	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690002031	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
103690002032	active site
103690002033	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690002034	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690002035	phosphopeptide binding site; other site
103690002036	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690002037	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690002038	active site
103690002039	ATP binding site [chemical binding]; other site
103690002040	substrate binding site [chemical binding]; other site
103690002041	activation loop (A-loop); other site
103690002042	hypothetical protein; Reviewed; Region: PRK12275
103690002043	four helix bundle protein; Region: TIGR02436
103690002044	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
103690002045	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690002046	Homeodomain-like domain; Region: HTH_23; pfam13384
103690002047	Winged helix-turn helix; Region: HTH_33; pfam13592
103690002048	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690002049	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690002050	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
103690002051	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
103690002052	trimer interface [polypeptide binding]; other site
103690002053	active site
103690002054	substrate binding site [chemical binding]; other site
103690002055	CoA binding site [chemical binding]; other site
103690002056	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
103690002057	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
103690002058	inhibitor-cofactor binding pocket; inhibition site
103690002059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690002060	catalytic residue [active]
103690002061	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690002062	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690002063	active site
103690002064	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690002065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690002066	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690002067	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
103690002068	active site
103690002069	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
103690002070	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690002071	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690002072	putative active site [active]
103690002073	XisI protein; Region: XisI; pfam08869
103690002074	XisI protein; Region: XisI; pfam08869
103690002075	TPR repeat; Region: TPR_11; pfam13414
103690002076	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690002077	binding surface
103690002078	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
103690002079	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
103690002080	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
103690002081	MltA specific insert domain; Region: MltA; pfam03562
103690002082	3D domain; Region: 3D; pfam06725
103690002083	Uncharacterized conserved protein [Function unknown]; Region: COG5607
103690002084	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
103690002085	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
103690002086	4Fe-4S binding domain; Region: Fer4; pfam00037
103690002087	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
103690002088	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
103690002089	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690002090	catalytic residues [active]
103690002091	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
103690002092	proposed catalytic triad [active]
103690002093	active site nucleophile [active]
103690002094	cyanophycin synthetase; Provisional; Region: PRK14016
103690002095	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
103690002096	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
103690002097	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
103690002098	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
103690002099	Uncharacterized conserved protein [Function unknown]; Region: COG3937
103690002100	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
103690002101	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
103690002102	replicative DNA helicase; Validated; Region: PRK07773
103690002103	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
103690002104	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
103690002105	Walker A motif; other site
103690002106	ATP binding site [chemical binding]; other site
103690002107	Walker B motif; other site
103690002108	DNA binding loops [nucleotide binding]
103690002109	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
103690002110	protein-splicing catalytic site; other site
103690002111	thioester formation/cholesterol transfer; other site
103690002112	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
103690002113	protein-splicing catalytic site; other site
103690002114	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
103690002115	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
103690002116	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
103690002117	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
103690002118	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
103690002119	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690002120	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690002121	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690002122	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690002123	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690002124	Walker A/P-loop; other site
103690002125	ATP binding site [chemical binding]; other site
103690002126	Q-loop/lid; other site
103690002127	ABC transporter signature motif; other site
103690002128	Walker B; other site
103690002129	D-loop; other site
103690002130	H-loop/switch region; other site
103690002131	His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388
103690002132	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690002133	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690002134	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
103690002135	Mannosyltransferase putative; Region: Mannosyl_trans3; pfam11051
103690002136	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690002137	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690002138	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690002139	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
103690002140	ABC1 family; Region: ABC1; cl17513
103690002141	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
103690002142	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
103690002143	Zn binding site [ion binding]; other site
103690002144	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
103690002145	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
103690002146	dimer interface [polypeptide binding]; other site
103690002147	[2Fe-2S] cluster binding site [ion binding]; other site
103690002148	S-layer homology domain; Region: SLH; pfam00395
103690002149	S-layer homology domain; Region: SLH; pfam00395
103690002150	S-layer homology domain; Region: SLH; pfam00395
103690002151	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
103690002152	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
103690002153	TPP-binding site; other site
103690002154	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
103690002155	PYR/PP interface [polypeptide binding]; other site
103690002156	dimer interface [polypeptide binding]; other site
103690002157	TPP binding site [chemical binding]; other site
103690002158	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
103690002159	hypothetical protein; Provisional; Region: PRK07394
103690002160	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
103690002161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690002162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690002163	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
103690002164	dimerization interface [polypeptide binding]; other site
103690002165	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690002166	non-specific DNA binding site [nucleotide binding]; other site
103690002167	salt bridge; other site
103690002168	sequence-specific DNA binding site [nucleotide binding]; other site
103690002169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4683
103690002170	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690002171	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
103690002172	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
103690002173	iron-sulfur cluster [ion binding]; other site
103690002174	[2Fe-2S] cluster binding site [ion binding]; other site
103690002175	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
103690002176	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690002177	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690002178	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
103690002179	NMT1-like family; Region: NMT1_2; pfam13379
103690002180	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
103690002181	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690002182	dimer interface [polypeptide binding]; other site
103690002183	conserved gate region; other site
103690002184	putative PBP binding loops; other site
103690002185	ABC-ATPase subunit interface; other site
103690002186	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690002187	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
103690002188	Walker A/P-loop; other site
103690002189	ATP binding site [chemical binding]; other site
103690002190	Q-loop/lid; other site
103690002191	ABC transporter signature motif; other site
103690002192	Walker B; other site
103690002193	D-loop; other site
103690002194	H-loop/switch region; other site
103690002195	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
103690002196	NMT1-like family; Region: NMT1_2; pfam13379
103690002197	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690002198	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
103690002199	Walker A/P-loop; other site
103690002200	ATP binding site [chemical binding]; other site
103690002201	Q-loop/lid; other site
103690002202	ABC transporter signature motif; other site
103690002203	Walker B; other site
103690002204	D-loop; other site
103690002205	H-loop/switch region; other site
103690002206	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
103690002207	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
103690002208	[4Fe-4S] binding site [ion binding]; other site
103690002209	molybdopterin cofactor binding site; other site
103690002210	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
103690002211	molybdopterin cofactor binding site; other site
103690002212	Predicted membrane protein [Function unknown]; Region: COG3431
103690002213	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
103690002214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685
103690002215	HEAT repeats; Region: HEAT_2; pfam13646
103690002216	HEAT repeats; Region: HEAT_2; pfam13646
103690002217	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690002218	CpeS-like protein; Region: CpeS; pfam09367
103690002219	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690002220	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690002221	ligand binding site [chemical binding]; other site
103690002222	flexible hinge region; other site
103690002223	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465
103690002224	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
103690002225	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690002226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690002227	S-adenosylmethionine binding site [chemical binding]; other site
103690002228	TPR repeat; Region: TPR_11; pfam13414
103690002229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690002230	binding surface
103690002231	TPR motif; other site
103690002232	TPR repeat; Region: TPR_11; pfam13414
103690002233	TPR repeat; Region: TPR_11; pfam13414
103690002234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690002235	binding surface
103690002236	TPR motif; other site
103690002237	TPR repeat; Region: TPR_11; pfam13414
103690002238	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
103690002239	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
103690002240	Cysteine-rich domain; Region: CCG; pfam02754
103690002241	Cysteine-rich domain; Region: CCG; pfam02754
103690002242	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
103690002243	FAD binding domain; Region: FAD_binding_4; pfam01565
103690002244	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690002245	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690002246	S-adenosylmethionine binding site [chemical binding]; other site
103690002247	calcium/proton exchanger (cax); Region: cax; TIGR00378
103690002248	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
103690002249	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
103690002250	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
103690002251	active site
103690002252	catalytic site [active]
103690002253	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
103690002254	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690002255	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690002256	active site
103690002257	KGK domain; Region: KGK; pfam08872
103690002258	KGK domain; Region: KGK; pfam08872
103690002259	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690002260	Ligand Binding Site [chemical binding]; other site
103690002261	phosphoenolpyruvate synthase; Validated; Region: PRK06464
103690002262	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
103690002263	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
103690002264	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
103690002265	Response regulator receiver domain; Region: Response_reg; pfam00072
103690002266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002267	active site
103690002268	phosphorylation site [posttranslational modification]
103690002269	intermolecular recognition site; other site
103690002270	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002271	dimerization interface [polypeptide binding]; other site
103690002272	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002273	dimer interface [polypeptide binding]; other site
103690002274	phosphorylation site [posttranslational modification]
103690002275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002276	ATP binding site [chemical binding]; other site
103690002277	Mg2+ binding site [ion binding]; other site
103690002278	G-X-G motif; other site
103690002279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002281	dimer interface [polypeptide binding]; other site
103690002282	phosphorylation site [posttranslational modification]
103690002283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002284	ATP binding site [chemical binding]; other site
103690002285	Mg2+ binding site [ion binding]; other site
103690002286	G-X-G motif; other site
103690002287	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690002288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002289	active site
103690002290	phosphorylation site [posttranslational modification]
103690002291	intermolecular recognition site; other site
103690002292	dimerization interface [polypeptide binding]; other site
103690002293	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
103690002294	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690002295	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690002296	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690002297	Walker A/P-loop; other site
103690002298	ATP binding site [chemical binding]; other site
103690002299	Q-loop/lid; other site
103690002300	ABC transporter signature motif; other site
103690002301	Walker B; other site
103690002302	D-loop; other site
103690002303	H-loop/switch region; other site
103690002304	Uncharacterized conserved protein [Function unknown]; Region: COG3339
103690002305	Cache domain; Region: Cache_1; pfam02743
103690002306	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690002307	dimerization interface [polypeptide binding]; other site
103690002308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002309	dimer interface [polypeptide binding]; other site
103690002310	phosphorylation site [posttranslational modification]
103690002311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002312	ATP binding site [chemical binding]; other site
103690002313	Mg2+ binding site [ion binding]; other site
103690002314	G-X-G motif; other site
103690002315	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
103690002316	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
103690002317	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
103690002318	Predicted membrane protein [Function unknown]; Region: COG1950
103690002319	Thf1-like protein; Reviewed; Region: PRK13266
103690002320	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
103690002321	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
103690002322	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690002323	anti sigma factor interaction site; other site
103690002324	regulatory phosphorylation site [posttranslational modification]; other site
103690002325	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
103690002326	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
103690002327	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
103690002328	hydrophobic ligand binding site; other site
103690002329	Domain of unknown function DUF59; Region: DUF59; pfam01883
103690002330	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
103690002331	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
103690002332	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
103690002333	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
103690002334	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690002335	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
103690002336	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
103690002337	Ligand Binding Site [chemical binding]; other site
103690002338	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690002339	Ligand Binding Site [chemical binding]; other site
103690002340	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690002341	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
103690002342	NAD binding site [chemical binding]; other site
103690002343	putative substrate binding site 2 [chemical binding]; other site
103690002344	putative substrate binding site 1 [chemical binding]; other site
103690002345	active site
103690002346	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
103690002347	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
103690002348	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
103690002349	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
103690002350	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
103690002351	putative deacylase active site [active]
103690002352	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
103690002353	cyclase homology domain; Region: CHD; cd07302
103690002354	nucleotidyl binding site; other site
103690002355	metal binding site [ion binding]; metal-binding site
103690002356	dimer interface [polypeptide binding]; other site
103690002357	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
103690002358	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
103690002359	active site
103690002360	catalytic site [active]
103690002361	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690002362	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690002363	structural tetrad; other site
103690002364	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690002365	structural tetrad; other site
103690002366	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690002367	WD40 repeats; Region: WD40; smart00320
103690002368	WD40 repeats; Region: WD40; smart00320
103690002369	CHAT domain; Region: CHAT; cl17868
103690002370	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690002371	Lysozyme family protein [General function prediction only]; Region: COG5526
103690002372	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690002373	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690002374	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690002375	structural tetrad; other site
103690002376	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
103690002377	active site
103690002378	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
103690002379	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
103690002380	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690002381	active site
103690002382	catalytic residues [active]
103690002383	DNA binding site [nucleotide binding]
103690002384	Int/Topo IB signature motif; other site
103690002385	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
103690002386	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
103690002387	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
103690002388	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
103690002389	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
103690002390	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690002391	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
103690002392	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
103690002393	Acylphosphatase; Region: Acylphosphatase; pfam00708
103690002394	HypF finger; Region: zf-HYPF; pfam07503
103690002395	HypF finger; Region: zf-HYPF; pfam07503
103690002396	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
103690002397	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypC; COG0298
103690002398	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
103690002399	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
103690002400	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
103690002401	active site 1 [active]
103690002402	dimer interface [polypeptide binding]; other site
103690002403	hexamer interface [polypeptide binding]; other site
103690002404	active site 2 [active]
103690002405	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
103690002406	dimerization interface [polypeptide binding]; other site
103690002407	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
103690002408	ATP binding site [chemical binding]; other site
103690002409	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
103690002410	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
103690002411	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690002412	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
103690002413	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
103690002414	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
103690002415	protein binding site [polypeptide binding]; other site
103690002416	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
103690002417	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690002418	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002419	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690002420	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002421	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002422	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
103690002423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002424	putative active site [active]
103690002425	heme pocket [chemical binding]; other site
103690002426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002428	dimer interface [polypeptide binding]; other site
103690002429	phosphorylation site [posttranslational modification]
103690002430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002431	ATP binding site [chemical binding]; other site
103690002432	Mg2+ binding site [ion binding]; other site
103690002433	G-X-G motif; other site
103690002434	Protein kinase domain; Region: Pkinase; pfam00069
103690002435	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690002436	active site
103690002437	ATP binding site [chemical binding]; other site
103690002438	substrate binding site [chemical binding]; other site
103690002439	substrate binding site [chemical binding]; other site
103690002440	activation loop (A-loop); other site
103690002441	activation loop (A-loop); other site
103690002442	AAA ATPase domain; Region: AAA_16; pfam13191
103690002443	Predicted ATPase [General function prediction only]; Region: COG3899
103690002444	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002445	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002446	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002447	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002448	dimer interface [polypeptide binding]; other site
103690002449	phosphorylation site [posttranslational modification]
103690002450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002451	ATP binding site [chemical binding]; other site
103690002452	Mg2+ binding site [ion binding]; other site
103690002453	G-X-G motif; other site
103690002454	Protein kinase domain; Region: Pkinase; pfam00069
103690002455	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690002456	active site
103690002457	ATP binding site [chemical binding]; other site
103690002458	substrate binding site [chemical binding]; other site
103690002459	activation loop (A-loop); other site
103690002460	AAA ATPase domain; Region: AAA_16; pfam13191
103690002461	Predicted ATPase [General function prediction only]; Region: COG3899
103690002462	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002463	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002464	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002466	ATP binding site [chemical binding]; other site
103690002467	Mg2+ binding site [ion binding]; other site
103690002468	G-X-G motif; other site
103690002469	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
103690002470	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
103690002471	nucleotide binding site [chemical binding]; other site
103690002472	glycogen branching enzyme; Provisional; Region: PRK05402
103690002473	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
103690002474	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
103690002475	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
103690002476	active site
103690002477	catalytic site [active]
103690002478	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
103690002479	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
103690002480	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
103690002481	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690002482	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
103690002483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
103690002484	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
103690002485	GTP-binding protein YchF; Reviewed; Region: PRK09601
103690002486	YchF GTPase; Region: YchF; cd01900
103690002487	G1 box; other site
103690002488	GTP/Mg2+ binding site [chemical binding]; other site
103690002489	Switch I region; other site
103690002490	G2 box; other site
103690002491	Switch II region; other site
103690002492	G3 box; other site
103690002493	G4 box; other site
103690002494	G5 box; other site
103690002495	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
103690002496	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
103690002497	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
103690002498	active site
103690002499	trimer interface [polypeptide binding]; other site
103690002500	allosteric site; other site
103690002501	active site lid [active]
103690002502	hexamer (dimer of trimers) interface [polypeptide binding]; other site
103690002503	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
103690002504	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690002505	active site
103690002506	motif I; other site
103690002507	motif II; other site
103690002508	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
103690002509	active site
103690002510	phosphorylation site [posttranslational modification]
103690002511	intermolecular recognition site; other site
103690002512	dimerization interface [polypeptide binding]; other site
103690002513	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002514	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002515	PAS domain S-box; Region: sensory_box; TIGR00229
103690002516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002517	putative active site [active]
103690002518	heme pocket [chemical binding]; other site
103690002519	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002520	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002521	PAS fold; Region: PAS_3; pfam08447
103690002522	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002523	putative active site [active]
103690002524	heme pocket [chemical binding]; other site
103690002525	PAS fold; Region: PAS_4; pfam08448
103690002526	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002527	GAF domain; Region: GAF; pfam01590
103690002528	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002529	dimer interface [polypeptide binding]; other site
103690002530	phosphorylation site [posttranslational modification]
103690002531	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002532	ATP binding site [chemical binding]; other site
103690002533	Mg2+ binding site [ion binding]; other site
103690002534	G-X-G motif; other site
103690002535	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690002536	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002537	active site
103690002538	phosphorylation site [posttranslational modification]
103690002539	intermolecular recognition site; other site
103690002540	dimerization interface [polypeptide binding]; other site
103690002541	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
103690002542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690002543	FeS/SAM binding site; other site
103690002544	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
103690002545	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
103690002546	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690002547	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690002548	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690002549	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
103690002550	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
103690002551	dimer interface [polypeptide binding]; other site
103690002552	catalytic residues [active]
103690002553	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
103690002554	UreF; Region: UreF; pfam01730
103690002555	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690002556	Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314
103690002557	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
103690002558	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690002559	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
103690002560	catalytic residues [active]
103690002561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690002562	dimer interface [polypeptide binding]; other site
103690002563	conserved gate region; other site
103690002564	putative PBP binding loops; other site
103690002565	ABC-ATPase subunit interface; other site
103690002566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
103690002567	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
103690002568	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
103690002569	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
103690002570	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690002571	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
103690002572	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
103690002573	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690002574	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690002575	phosphopeptide binding site; other site
103690002576	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002577	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002578	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
103690002579	cyclase homology domain; Region: CHD; cd07302
103690002580	nucleotidyl binding site; other site
103690002581	metal binding site [ion binding]; metal-binding site
103690002582	dimer interface [polypeptide binding]; other site
103690002583	VanZ like family; Region: VanZ; cl01971
103690002584	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
103690002585	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
103690002586	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
103690002587	GTP/Mg2+ binding site [chemical binding]; other site
103690002588	G4 box; other site
103690002589	G5 box; other site
103690002590	G1 box; other site
103690002591	Switch I region; other site
103690002592	G2 box; other site
103690002593	G3 box; other site
103690002594	Switch II region; other site
103690002595	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
103690002596	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690002597	active site
103690002598	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
103690002599	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
103690002600	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
103690002601	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
103690002602	16S/18S rRNA binding site [nucleotide binding]; other site
103690002603	S13e-L30e interaction site [polypeptide binding]; other site
103690002604	25S rRNA binding site [nucleotide binding]; other site
103690002605	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690002606	Ligand Binding Site [chemical binding]; other site
103690002607	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
103690002608	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
103690002609	putative dimer interface [polypeptide binding]; other site
103690002610	[2Fe-2S] cluster binding site [ion binding]; other site
103690002611	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
103690002612	dimer interface [polypeptide binding]; other site
103690002613	[2Fe-2S] cluster binding site [ion binding]; other site
103690002614	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
103690002615	SLBB domain; Region: SLBB; pfam10531
103690002616	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
103690002617	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690002618	putative active site [active]
103690002619	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
103690002620	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
103690002621	PemK-like protein; Region: PemK; pfam02452
103690002622	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690002623	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690002624	structural tetrad; other site
103690002625	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690002626	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690002627	structural tetrad; other site
103690002628	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
103690002629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
103690002630	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
103690002631	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
103690002632	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
103690002633	4Fe-4S binding domain; Region: Fer4; pfam00037
103690002634	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
103690002635	Coenzyme F420-reducing hydrogenase, gamma subunit [Energy production and conversion]; Region: FrhG; COG1941
103690002636	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
103690002637	FOG: CBS domain [General function prediction only]; Region: COG0517
103690002638	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
103690002639	CP12 domain; Region: CP12; pfam02672
103690002640	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
103690002641	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
103690002642	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
103690002643	homotrimer interaction site [polypeptide binding]; other site
103690002644	putative active site [active]
103690002645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
103690002646	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
103690002647	CoA binding domain; Region: CoA_binding_2; pfam13380
103690002648	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
103690002649	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
103690002650	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
103690002651	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690002652	Coenzyme A binding pocket [chemical binding]; other site
103690002653	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
103690002654	nickel binding site [ion binding]; other site
103690002655	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
103690002656	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
103690002657	dimer interface [polypeptide binding]; other site
103690002658	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
103690002659	active site
103690002660	Fe binding site [ion binding]; other site
103690002661	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690002662	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690002663	S-adenosylmethionine binding site [chemical binding]; other site
103690002664	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690002665	Response regulator receiver domain; Region: Response_reg; pfam00072
103690002666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002667	active site
103690002668	phosphorylation site [posttranslational modification]
103690002669	intermolecular recognition site; other site
103690002670	dimerization interface [polypeptide binding]; other site
103690002671	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
103690002672	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
103690002673	Active site cavity [active]
103690002674	catalytic acid [active]
103690002675	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
103690002676	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
103690002677	DXD motif; other site
103690002678	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690002679	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
103690002680	serpin-like protein; Provisional; Region: PHA02660
103690002681	reactive center loop; other site
103690002682	Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488
103690002683	putative catalytic residues [active]
103690002684	putative active site [active]
103690002685	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
103690002686	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
103690002687	substrate binding site [chemical binding]; other site
103690002688	hexamer interface [polypeptide binding]; other site
103690002689	metal binding site [ion binding]; metal-binding site
103690002690	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
103690002691	FAD binding site [chemical binding]; other site
103690002692	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690002693	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690002694	catalytic loop [active]
103690002695	iron binding site [ion binding]; other site
103690002696	Archaeal protein of unknown function (DUF650); Region: DUF650; pfam04894
103690002697	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
103690002698	CAAX protease self-immunity; Region: Abi; pfam02517
103690002699	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
103690002700	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
103690002701	active site
103690002702	substrate binding site [chemical binding]; other site
103690002703	cosubstrate binding site; other site
103690002704	catalytic site [active]
103690002705	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
103690002706	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690002707	dimer interface [polypeptide binding]; other site
103690002708	conserved gate region; other site
103690002709	putative PBP binding loops; other site
103690002710	ABC-ATPase subunit interface; other site
103690002711	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690002712	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
103690002713	putative acyl-acceptor binding pocket; other site
103690002714	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690002715	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
103690002716	putative hydrophobic ligand binding site [chemical binding]; other site
103690002717	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
103690002718	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
103690002719	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690002720	FeS/SAM binding site; other site
103690002721	Uncharacterized conserved protein [Function unknown]; Region: COG4095
103690002722	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
103690002723	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
103690002724	Tetramer interface [polypeptide binding]; other site
103690002725	active site
103690002726	FMN-binding site [chemical binding]; other site
103690002727	BolA-like protein; Region: BolA; pfam01722
103690002728	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
103690002729	putative GSH binding site [chemical binding]; other site
103690002730	catalytic residues [active]
103690002731	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
103690002732	MPT binding site; other site
103690002733	trimer interface [polypeptide binding]; other site
103690002734	photosystem II reaction center protein Psb28; Provisional; Region: PRK13612
103690002735	hypothetical protein; Provisional; Region: PRK11281
103690002736	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
103690002737	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
103690002738	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
103690002739	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690002740	Walker A/P-loop; other site
103690002741	ATP binding site [chemical binding]; other site
103690002742	Q-loop/lid; other site
103690002743	ABC transporter signature motif; other site
103690002744	Walker B; other site
103690002745	D-loop; other site
103690002746	H-loop/switch region; other site
103690002747	DevC protein; Region: devC; TIGR01185
103690002748	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690002749	FtsX-like permease family; Region: FtsX; pfam02687
103690002750	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690002751	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690002752	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690002753	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690002754	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690002755	RDD family; Region: RDD; pfam06271
103690002756	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690002757	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002758	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002759	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002760	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690002761	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002762	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690002763	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
103690002764	16S rRNA methyltransferase B; Provisional; Region: PRK14901
103690002765	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
103690002766	putative RNA binding site [nucleotide binding]; other site
103690002767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690002768	S-adenosylmethionine binding site [chemical binding]; other site
103690002769	tellurium resistance terB-like protein; Region: terB_like; cd07177
103690002770	metal binding site [ion binding]; metal-binding site
103690002771	Response regulator receiver domain; Region: Response_reg; pfam00072
103690002772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002773	active site
103690002774	phosphorylation site [posttranslational modification]
103690002775	intermolecular recognition site; other site
103690002776	dimerization interface [polypeptide binding]; other site
103690002777	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002778	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690002779	putative active site [active]
103690002780	heme pocket [chemical binding]; other site
103690002781	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690002782	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002783	putative active site [active]
103690002784	heme pocket [chemical binding]; other site
103690002785	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690002786	putative active site [active]
103690002787	heme pocket [chemical binding]; other site
103690002788	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690002789	PAS domain; Region: PAS; smart00091
103690002790	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002791	dimer interface [polypeptide binding]; other site
103690002792	phosphorylation site [posttranslational modification]
103690002793	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002794	ATP binding site [chemical binding]; other site
103690002795	Mg2+ binding site [ion binding]; other site
103690002796	G-X-G motif; other site
103690002797	Response regulator receiver domain; Region: Response_reg; pfam00072
103690002798	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002799	active site
103690002800	phosphorylation site [posttranslational modification]
103690002801	intermolecular recognition site; other site
103690002802	dimerization interface [polypeptide binding]; other site
103690002803	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690002804	phosphorylation site [posttranslational modification]
103690002805	GAF domain; Region: GAF_2; pfam13185
103690002806	GAF domain; Region: GAF_3; pfam13492
103690002807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002808	dimer interface [polypeptide binding]; other site
103690002809	phosphorylation site [posttranslational modification]
103690002810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002811	ATP binding site [chemical binding]; other site
103690002812	Mg2+ binding site [ion binding]; other site
103690002813	G-X-G motif; other site
103690002814	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
103690002815	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
103690002816	active site
103690002817	FMN binding site [chemical binding]; other site
103690002818	substrate binding site [chemical binding]; other site
103690002819	homotetramer interface [polypeptide binding]; other site
103690002820	catalytic residue [active]
103690002821	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690002822	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
103690002823	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690002824	dimer interface [polypeptide binding]; other site
103690002825	putative PBP binding regions; other site
103690002826	ABC-ATPase subunit  interface; other site
103690002827	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690002828	dimerization interface [polypeptide binding]; other site
103690002829	putative DNA binding site [nucleotide binding]; other site
103690002830	putative Zn2+ binding site [ion binding]; other site
103690002831	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
103690002832	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
103690002833	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
103690002834	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
103690002835	metal binding site [ion binding]; metal-binding site
103690002836	S-layer homology domain; Region: SLH; pfam00395
103690002837	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690002838	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
103690002839	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
103690002840	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
103690002841	active site
103690002842	Zn binding site [ion binding]; other site
103690002843	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
103690002844	AAA ATPase domain; Region: AAA_16; pfam13191
103690002845	AAA ATPase domain; Region: AAA_16; pfam13191
103690002846	AAA domain; Region: AAA_22; pfam13401
103690002847	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690002848	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
103690002849	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
103690002850	putative active site [active]
103690002851	catalytic residue [active]
103690002852	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
103690002853	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
103690002854	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
103690002855	Photosystem II reaction centre N protein (psbN); Region: PsbN; pfam02468
103690002856	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
103690002857	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
103690002858	active site
103690002859	catalytic site [active]
103690002860	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
103690002861	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690002862	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
103690002863	putative acyl-acceptor binding pocket; other site
103690002864	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
103690002865	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690002866	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
103690002867	putative hydrophobic ligand binding site [chemical binding]; other site
103690002868	GAF domain; Region: GAF; pfam01590
103690002869	GAF domain; Region: GAF; pfam01590
103690002870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690002871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002872	dimer interface [polypeptide binding]; other site
103690002873	phosphorylation site [posttranslational modification]
103690002874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690002875	ATP binding site [chemical binding]; other site
103690002876	Mg2+ binding site [ion binding]; other site
103690002877	G-X-G motif; other site
103690002878	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690002879	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690002880	active site
103690002881	Tic20-like protein; Region: Tic20; pfam09685
103690002882	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
103690002883	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
103690002884	putative active site [active]
103690002885	catalytic triad [active]
103690002886	putative dimer interface [polypeptide binding]; other site
103690002887	DNA gyrase subunit A; Validated; Region: PRK05560
103690002888	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
103690002889	CAP-like domain; other site
103690002890	active site
103690002891	primary dimer interface [polypeptide binding]; other site
103690002892	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002893	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002894	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002895	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002896	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002897	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
103690002898	conserved hypothetical protein; Region: TIGR02231
103690002899	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
103690002900	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
103690002901	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690002902	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690002903	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
103690002904	putative dimerization interface [polypeptide binding]; other site
103690002905	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690002906	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690002907	Hexamer interface [polypeptide binding]; other site
103690002908	Hexagonal pore residue; other site
103690002909	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690002910	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690002911	Hexamer interface [polypeptide binding]; other site
103690002912	Hexagonal pore residue; other site
103690002913	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
103690002914	putative trimer interface [polypeptide binding]; other site
103690002915	putative CoA binding site [chemical binding]; other site
103690002916	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
103690002917	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
103690002918	trimer interface [polypeptide binding]; other site
103690002919	active site
103690002920	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
103690002921	putative multimerization interface [polypeptide binding]; other site
103690002922	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
103690002923	putative multimerization interface [polypeptide binding]; other site
103690002924	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
103690002925	putative multimerization interface [polypeptide binding]; other site
103690002926	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
103690002927	Hexamer/Pentamer interface [polypeptide binding]; other site
103690002928	central pore; other site
103690002929	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690002930	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690002931	Hexamer interface [polypeptide binding]; other site
103690002932	Hexagonal pore residue; other site
103690002933	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
103690002934	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
103690002935	Hexamer interface [polypeptide binding]; other site
103690002936	Hexagonal pore residue; other site
103690002937	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
103690002938	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690002939	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
103690002940	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690002941	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
103690002942	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690002943	HEAT repeats; Region: HEAT_2; pfam13646
103690002944	HEAT repeats; Region: HEAT_2; pfam13646
103690002945	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
103690002946	nitrogenase reductase; Reviewed; Region: PRK13236
103690002947	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
103690002948	Nucleotide-binding sites [chemical binding]; other site
103690002949	Walker A motif; other site
103690002950	Switch I region of nucleotide binding site; other site
103690002951	Fe4S4 binding sites [ion binding]; other site
103690002952	Switch II region of nucleotide binding site; other site
103690002953	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
103690002954	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
103690002955	glycogen binding site [chemical binding]; other site
103690002956	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_4; cd11350
103690002957	active site
103690002958	catalytic site [active]
103690002959	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
103690002960	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
103690002961	acylphosphatase; Provisional; Region: PRK14423
103690002962	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
103690002963	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690002964	Coenzyme A binding pocket [chemical binding]; other site
103690002965	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
103690002966	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
103690002967	putative NAD(P) binding site [chemical binding]; other site
103690002968	putative substrate binding site [chemical binding]; other site
103690002969	catalytic Zn binding site [ion binding]; other site
103690002970	structural Zn binding site [ion binding]; other site
103690002971	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
103690002972	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
103690002973	active site
103690002974	Zn binding site [ion binding]; other site
103690002975	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
103690002976	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690002977	Ligand Binding Site [chemical binding]; other site
103690002978	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690002979	Ligand Binding Site [chemical binding]; other site
103690002980	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
103690002981	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690002982	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690002983	catalytic loop [active]
103690002984	iron binding site [ion binding]; other site
103690002985	Photosystem II 4 kDa reaction centre component; Region: PsbK; pfam02533
103690002986	Protein kinase domain; Region: Pkinase; pfam00069
103690002987	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690002988	active site
103690002989	ATP binding site [chemical binding]; other site
103690002990	substrate binding site [chemical binding]; other site
103690002991	activation loop (A-loop); other site
103690002992	AAA ATPase domain; Region: AAA_16; pfam13191
103690002993	Predicted ATPase [General function prediction only]; Region: COG3899
103690002994	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690002995	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690002996	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690002997	dimer interface [polypeptide binding]; other site
103690002998	phosphorylation site [posttranslational modification]
103690002999	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003000	ATP binding site [chemical binding]; other site
103690003001	Mg2+ binding site [ion binding]; other site
103690003002	G-X-G motif; other site
103690003003	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
103690003004	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
103690003005	tetramer (dimer of dimers) interface [polypeptide binding]; other site
103690003006	active site
103690003007	dimer interface [polypeptide binding]; other site
103690003008	TPR repeat; Region: TPR_11; pfam13414
103690003009	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003010	binding surface
103690003011	TPR motif; other site
103690003012	TPR repeat; Region: TPR_11; pfam13414
103690003013	TPR repeat; Region: TPR_11; pfam13414
103690003014	TPR repeat; Region: TPR_11; pfam13414
103690003015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003016	binding surface
103690003017	TPR motif; other site
103690003018	TPR repeat; Region: TPR_11; pfam13414
103690003019	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003020	binding surface
103690003021	TPR motif; other site
103690003022	TPR repeat; Region: TPR_11; pfam13414
103690003023	TPR repeat; Region: TPR_11; pfam13414
103690003024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003025	binding surface
103690003026	TPR motif; other site
103690003027	TPR repeat; Region: TPR_11; pfam13414
103690003028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003029	binding surface
103690003030	TPR motif; other site
103690003031	TPR repeat; Region: TPR_11; pfam13414
103690003032	TPR repeat; Region: TPR_11; pfam13414
103690003033	Uncharacterized conserved protein [Function unknown]; Region: COG5502
103690003034	intracellular protease, PfpI family; Region: PfpI; TIGR01382
103690003035	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
103690003036	proposed catalytic triad [active]
103690003037	conserved cys residue [active]
103690003038	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
103690003039	dinuclear metal binding motif [ion binding]; other site
103690003040	Predicted integral membrane protein [Function unknown]; Region: COG5637
103690003041	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
103690003042	putative hydrophobic ligand binding site [chemical binding]; other site
103690003043	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
103690003044	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
103690003045	NAD binding site [chemical binding]; other site
103690003046	catalytic Zn binding site [ion binding]; other site
103690003047	structural Zn binding site [ion binding]; other site
103690003048	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
103690003049	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
103690003050	NAD binding site [chemical binding]; other site
103690003051	catalytic Zn binding site [ion binding]; other site
103690003052	structural Zn binding site [ion binding]; other site
103690003053	Cupin domain; Region: Cupin_2; pfam07883
103690003054	Protein kinase domain; Region: Pkinase; pfam00069
103690003055	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690003056	active site
103690003057	ATP binding site [chemical binding]; other site
103690003058	substrate binding site [chemical binding]; other site
103690003059	activation loop (A-loop); other site
103690003060	AAA ATPase domain; Region: AAA_16; pfam13191
103690003061	Predicted ATPase [General function prediction only]; Region: COG3899
103690003062	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003063	GAF domain; Region: GAF; pfam01590
103690003064	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690003065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003066	ATP binding site [chemical binding]; other site
103690003067	Mg2+ binding site [ion binding]; other site
103690003068	G-X-G motif; other site
103690003069	Uncharacterized conserved protein [Function unknown]; Region: COG1801
103690003070	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
103690003071	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
103690003072	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
103690003073	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
103690003074	active site residue [active]
103690003075	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
103690003076	active site residue [active]
103690003077	Dynamin family; Region: Dynamin_N; pfam00350
103690003078	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
103690003079	G1 box; other site
103690003080	GTP/Mg2+ binding site [chemical binding]; other site
103690003081	Switch I region; other site
103690003082	G2 box; other site
103690003083	Switch II region; other site
103690003084	G3 box; other site
103690003085	G4 box; other site
103690003086	G5 box; other site
103690003087	Domain of unknown function (DUF697); Region: DUF697; pfam05128
103690003088	CP12 domain; Region: CP12; pfam02672
103690003089	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
103690003090	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
103690003091	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258
103690003092	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
103690003093	Walker A/P-loop; other site
103690003094	ATP binding site [chemical binding]; other site
103690003095	Q-loop/lid; other site
103690003096	ABC transporter signature motif; other site
103690003097	Walker B; other site
103690003098	D-loop; other site
103690003099	H-loop/switch region; other site
103690003100	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14260
103690003101	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
103690003102	Walker A/P-loop; other site
103690003103	ATP binding site [chemical binding]; other site
103690003104	Q-loop/lid; other site
103690003105	ABC transporter signature motif; other site
103690003106	Walker B; other site
103690003107	D-loop; other site
103690003108	H-loop/switch region; other site
103690003109	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
103690003110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690003111	dimer interface [polypeptide binding]; other site
103690003112	conserved gate region; other site
103690003113	putative PBP binding loops; other site
103690003114	ABC-ATPase subunit interface; other site
103690003115	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
103690003116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690003117	dimer interface [polypeptide binding]; other site
103690003118	conserved gate region; other site
103690003119	putative PBP binding loops; other site
103690003120	ABC-ATPase subunit interface; other site
103690003121	PBP superfamily domain; Region: PBP_like_2; cl17296
103690003122	GTPase Era; Reviewed; Region: era; PRK00089
103690003123	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
103690003124	G1 box; other site
103690003125	GTP/Mg2+ binding site [chemical binding]; other site
103690003126	Switch I region; other site
103690003127	G2 box; other site
103690003128	Switch II region; other site
103690003129	G3 box; other site
103690003130	G4 box; other site
103690003131	G5 box; other site
103690003132	KH domain; Region: KH_2; pfam07650
103690003133	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003135	active site
103690003136	phosphorylation site [posttranslational modification]
103690003137	intermolecular recognition site; other site
103690003138	dimerization interface [polypeptide binding]; other site
103690003139	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690003140	DNA binding residues [nucleotide binding]
103690003141	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690003142	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690003143	active site
103690003144	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690003145	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690003146	active site
103690003147	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
103690003148	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
103690003149	Walker A/P-loop; other site
103690003150	ATP binding site [chemical binding]; other site
103690003151	Q-loop/lid; other site
103690003152	ABC transporter signature motif; other site
103690003153	Walker B; other site
103690003154	D-loop; other site
103690003155	H-loop/switch region; other site
103690003156	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
103690003157	putative carbohydrate binding site [chemical binding]; other site
103690003158	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
103690003159	ABC-2 type transporter; Region: ABC2_membrane; cl17235
103690003160	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690003161	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690003162	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
103690003163	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
103690003164	putative ADP-binding pocket [chemical binding]; other site
103690003165	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
103690003166	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
103690003167	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
103690003168	iron-sulfur cluster [ion binding]; other site
103690003169	[2Fe-2S] cluster binding site [ion binding]; other site
103690003170	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690003171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4296
103690003172	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690003173	putative binding surface; other site
103690003174	active site
103690003175	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
103690003176	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
103690003177	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003178	ATP binding site [chemical binding]; other site
103690003179	Mg2+ binding site [ion binding]; other site
103690003180	G-X-G motif; other site
103690003181	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
103690003182	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003183	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003184	active site
103690003185	phosphorylation site [posttranslational modification]
103690003186	intermolecular recognition site; other site
103690003187	dimerization interface [polypeptide binding]; other site
103690003188	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003189	dimerization interface [polypeptide binding]; other site
103690003190	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
103690003191	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
103690003192	dimer interface [polypeptide binding]; other site
103690003193	putative CheW interface [polypeptide binding]; other site
103690003194	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
103690003195	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003196	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003197	active site
103690003198	phosphorylation site [posttranslational modification]
103690003199	intermolecular recognition site; other site
103690003200	dimerization interface [polypeptide binding]; other site
103690003201	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
103690003202	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003204	active site
103690003205	phosphorylation site [posttranslational modification]
103690003206	intermolecular recognition site; other site
103690003207	dimerization interface [polypeptide binding]; other site
103690003208	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
103690003209	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
103690003210	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
103690003211	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
103690003212	Ligand Binding Site [chemical binding]; other site
103690003213	SinI restriction endonuclease; Region: RE_SinI; pfam09570
103690003214	Helix-turn-helix domain; Region: HTH_17; pfam12728
103690003215	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690003216	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690003217	cofactor binding site; other site
103690003218	DNA binding site [nucleotide binding]
103690003219	substrate interaction site [chemical binding]; other site
103690003220	KGK domain; Region: KGK; pfam08872
103690003221	cytochrome c biogenesis protein; Region: ccsA; CHL00045
103690003222	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
103690003223	Protein of unknown function (DUF98); Region: DUF98; pfam01947
103690003224	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
103690003225	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
103690003226	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
103690003227	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
103690003228	Predicted integral membrane protein [Function unknown]; Region: COG0762
103690003229	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
103690003230	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
103690003231	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
103690003232	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
103690003233	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
103690003234	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
103690003235	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
103690003236	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
103690003237	CAAX protease self-immunity; Region: Abi; pfam02517
103690003238	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
103690003239	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690003240	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
103690003241	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
103690003242	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
103690003243	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
103690003244	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
103690003245	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
103690003246	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
103690003247	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
103690003248	D-pathway; other site
103690003249	Putative ubiquinol binding site [chemical binding]; other site
103690003250	Low-spin heme (heme b) binding site [chemical binding]; other site
103690003251	Putative water exit pathway; other site
103690003252	Binuclear center (heme o3/CuB) [ion binding]; other site
103690003253	K-pathway; other site
103690003254	Putative proton exit pathway; other site
103690003255	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
103690003256	Subunit I/III interface [polypeptide binding]; other site
103690003257	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
103690003258	Inward rectifier potassium channel; Region: IRK; pfam01007
103690003259	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
103690003260	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
103690003261	pheophorbide a oxygenase; Region: PLN02518
103690003262	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
103690003263	metal binding site 2 [ion binding]; metal-binding site
103690003264	putative DNA binding helix; other site
103690003265	metal binding site 1 [ion binding]; metal-binding site
103690003266	dimer interface [polypeptide binding]; other site
103690003267	structural Zn2+ binding site [ion binding]; other site
103690003268	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690003269	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003270	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690003271	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
103690003273	active site
103690003274	phosphorylation site [posttranslational modification]
103690003275	intermolecular recognition site; other site
103690003276	dimerization interface [polypeptide binding]; other site
103690003277	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
103690003278	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
103690003279	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
103690003280	GTP binding site; other site
103690003281	TPR repeat; Region: TPR_11; pfam13414
103690003282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690003283	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
103690003284	SPFH domain / Band 7 family; Region: Band_7; pfam01145
103690003285	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
103690003286	active site
103690003287	catalytic site [active]
103690003288	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
103690003289	classical (c) SDRs; Region: SDR_c; cd05233
103690003290	NAD(P) binding site [chemical binding]; other site
103690003291	active site
103690003292	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
103690003293	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
103690003294	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690003295	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690003296	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
103690003297	Walker A/P-loop; other site
103690003298	ATP binding site [chemical binding]; other site
103690003299	Q-loop/lid; other site
103690003300	ABC transporter signature motif; other site
103690003301	Walker B; other site
103690003302	D-loop; other site
103690003303	H-loop/switch region; other site
103690003304	Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000
103690003305	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
103690003306	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
103690003307	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
103690003308	Walker A/P-loop; other site
103690003309	ATP binding site [chemical binding]; other site
103690003310	Q-loop/lid; other site
103690003311	ABC transporter signature motif; other site
103690003312	Walker B; other site
103690003313	D-loop; other site
103690003314	H-loop/switch region; other site
103690003315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690003316	dimer interface [polypeptide binding]; other site
103690003317	conserved gate region; other site
103690003318	ABC-ATPase subunit interface; other site
103690003319	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
103690003320	Phytochelatin synthase; Region: Phytochelatin; pfam05023
103690003321	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
103690003322	active site
103690003323	catalytic triad [active]
103690003324	oxyanion hole [active]
103690003325	PAS fold; Region: PAS_4; pfam08448
103690003326	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690003327	putative active site [active]
103690003328	heme pocket [chemical binding]; other site
103690003329	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690003330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690003331	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690003332	putative active site [active]
103690003333	heme pocket [chemical binding]; other site
103690003334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690003335	putative active site [active]
103690003336	heme pocket [chemical binding]; other site
103690003337	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003338	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690003339	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690003340	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003341	dimer interface [polypeptide binding]; other site
103690003342	phosphorylation site [posttranslational modification]
103690003343	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003344	ATP binding site [chemical binding]; other site
103690003345	Mg2+ binding site [ion binding]; other site
103690003346	G-X-G motif; other site
103690003347	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003349	active site
103690003350	phosphorylation site [posttranslational modification]
103690003351	intermolecular recognition site; other site
103690003352	dimerization interface [polypeptide binding]; other site
103690003353	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
103690003354	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
103690003355	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
103690003356	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690003357	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
103690003358	putative acyl-acceptor binding pocket; other site
103690003359	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
103690003360	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
103690003361	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
103690003362	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
103690003363	active site
103690003364	Zn binding site [ion binding]; other site
103690003365	Uncharacterized conserved protein [Function unknown]; Region: COG2947
103690003366	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
103690003367	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
103690003368	Domain of unknown function (DUF897); Region: DUF897; pfam05982
103690003369	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
103690003370	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
103690003371	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
103690003372	active site
103690003373	dimer interface [polypeptide binding]; other site
103690003374	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
103690003375	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
103690003376	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
103690003377	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
103690003378	HEAT-like repeat; Region: HEAT_EZ; pfam13513
103690003379	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690003380	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
103690003381	catalytic triad [active]
103690003382	putative active site [active]
103690003383	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
103690003384	dimanganese center [ion binding]; other site
103690003385	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690003386	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690003387	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690003388	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
103690003389	putative ADP-binding pocket [chemical binding]; other site
103690003390	Domain of unknown function (DUF4383); Region: DUF4383; pfam14325
103690003391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4446
103690003392	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
103690003393	homodimer interface [polypeptide binding]; other site
103690003394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690003395	catalytic residue [active]
103690003396	Uncharacterized membrane-anchored protein [Function unknown]; Region: COG4929
103690003397	Predicted membrane protein [Function unknown]; Region: COG4872
103690003398	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
103690003399	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
103690003400	Calcium binding; Region: Calci_bind_CcbP; pfam11535
103690003401	maltose O-acetyltransferase; Provisional; Region: PRK10092
103690003402	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
103690003403	active site
103690003404	substrate binding site [chemical binding]; other site
103690003405	trimer interface [polypeptide binding]; other site
103690003406	CoA binding site [chemical binding]; other site
103690003407	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003408	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003409	active site
103690003410	phosphorylation site [posttranslational modification]
103690003411	intermolecular recognition site; other site
103690003412	dimerization interface [polypeptide binding]; other site
103690003413	PAS fold; Region: PAS; pfam00989
103690003414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690003415	putative active site [active]
103690003416	heme pocket [chemical binding]; other site
103690003417	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690003418	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690003419	metal binding site [ion binding]; metal-binding site
103690003420	active site
103690003421	I-site; other site
103690003422	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
103690003423	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690003424	catalytic residues [active]
103690003425	KGK domain; Region: KGK; pfam08872
103690003426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
103690003427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
103690003428	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
103690003429	amidase; Provisional; Region: PRK09201
103690003430	Amidase; Region: Amidase; cl11426
103690003431	methionine aminopeptidase; Provisional; Region: PRK12318
103690003432	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
103690003433	active site
103690003434	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
103690003435	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690003436	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690003437	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690003438	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690003439	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690003440	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690003441	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690003442	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
103690003443	active site
103690003444	metal binding site [ion binding]; metal-binding site
103690003445	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
103690003446	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
103690003447	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
103690003448	trimer interface [polypeptide binding]; other site
103690003449	putative metal binding site [ion binding]; other site
103690003450	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
103690003451	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690003452	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
103690003453	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
103690003454	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
103690003455	Cell division protein FtsA; Region: FtsA; cl17206
103690003456	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
103690003457	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
103690003458	AMIN domain; Region: AMIN; pfam11741
103690003459	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
103690003460	Secretin and TonB N terminus short domain; Region: STN; pfam07660
103690003461	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
103690003462	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
103690003463	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
103690003464	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690003465	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690003466	non-specific DNA binding site [nucleotide binding]; other site
103690003467	salt bridge; other site
103690003468	sequence-specific DNA binding site [nucleotide binding]; other site
103690003469	Phage-related protein [Function unknown]; Region: COG4679
103690003470	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690003471	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690003472	ligand binding site [chemical binding]; other site
103690003473	flexible hinge region; other site
103690003474	Uncharacterized conserved protein [Function unknown]; Region: COG1615
103690003475	Uncharacterized conserved protein [Function unknown]; Region: COG1615
103690003476	aspartate aminotransferase; Provisional; Region: PRK05957
103690003477	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690003478	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690003479	homodimer interface [polypeptide binding]; other site
103690003480	catalytic residue [active]
103690003481	Uncharacterized conserved protein [Function unknown]; Region: COG0432
103690003482	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
103690003483	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
103690003484	putative active site [active]
103690003485	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
103690003486	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
103690003487	tRNA; other site
103690003488	putative tRNA binding site [nucleotide binding]; other site
103690003489	putative NADP binding site [chemical binding]; other site
103690003490	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
103690003491	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690003492	putative active site [active]
103690003493	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
103690003494	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690003495	dimerization interface [polypeptide binding]; other site
103690003496	putative DNA binding site [nucleotide binding]; other site
103690003497	putative Zn2+ binding site [ion binding]; other site
103690003498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3860
103690003499	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
103690003500	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
103690003501	Walker A/P-loop; other site
103690003502	ATP binding site [chemical binding]; other site
103690003503	Q-loop/lid; other site
103690003504	ABC transporter signature motif; other site
103690003505	Walker B; other site
103690003506	D-loop; other site
103690003507	H-loop/switch region; other site
103690003508	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
103690003509	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
103690003510	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
103690003511	TM-ABC transporter signature motif; other site
103690003512	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
103690003513	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
103690003514	active site
103690003515	dimer interface [polypeptide binding]; other site
103690003516	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
103690003517	dimer interface [polypeptide binding]; other site
103690003518	active site
103690003519	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
103690003520	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
103690003521	putative active site [active]
103690003522	catalytic site [active]
103690003523	putative metal binding site [ion binding]; other site
103690003524	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690003525	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
103690003526	Helix-turn-helix domain; Region: HTH_25; pfam13413
103690003527	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
103690003528	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
103690003529	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
103690003530	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
103690003531	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
103690003532	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
103690003533	generic binding surface I; other site
103690003534	generic binding surface II; other site
103690003535	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
103690003536	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
103690003537	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
103690003538	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
103690003539	beta-phosphoglucomutase; Region: bPGM; TIGR01990
103690003540	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690003541	sucrose synthase; Region: sucr_synth; TIGR02470
103690003542	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
103690003543	putative ADP-binding pocket [chemical binding]; other site
103690003544	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
103690003545	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
103690003546	putative molybdopterin cofactor binding site [chemical binding]; other site
103690003547	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
103690003548	putative molybdopterin cofactor binding site; other site
103690003549	methionine sulfoxide reductase A; Provisional; Region: PRK13014
103690003550	Pirin-related protein [General function prediction only]; Region: COG1741
103690003551	Pirin; Region: Pirin; pfam02678
103690003552	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
103690003553	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
103690003554	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
103690003555	Low molecular weight phosphatase family; Region: LMWPc; cd00115
103690003556	active site
103690003557	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690003558	putative binding surface; other site
103690003559	active site
103690003560	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
103690003561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003562	ATP binding site [chemical binding]; other site
103690003563	Mg2+ binding site [ion binding]; other site
103690003564	G-X-G motif; other site
103690003565	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
103690003566	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003568	active site
103690003569	phosphorylation site [posttranslational modification]
103690003570	intermolecular recognition site; other site
103690003571	dimerization interface [polypeptide binding]; other site
103690003572	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003573	GAF domain; Region: GAF; pfam01590
103690003574	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003575	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690003576	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003577	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690003578	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003579	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690003580	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
103690003581	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
103690003582	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
103690003583	dimer interface [polypeptide binding]; other site
103690003584	putative CheW interface [polypeptide binding]; other site
103690003585	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
103690003586	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003587	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003588	active site
103690003589	phosphorylation site [posttranslational modification]
103690003590	intermolecular recognition site; other site
103690003591	dimerization interface [polypeptide binding]; other site
103690003592	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003594	active site
103690003595	phosphorylation site [posttranslational modification]
103690003596	intermolecular recognition site; other site
103690003597	dimerization interface [polypeptide binding]; other site
103690003598	isoleucyl-tRNA synthetase; Region: PLN02843
103690003599	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
103690003600	HIGH motif; other site
103690003601	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
103690003602	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
103690003603	active site
103690003604	KMSKS motif; other site
103690003605	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
103690003606	tRNA binding surface [nucleotide binding]; other site
103690003607	anticodon binding site; other site
103690003608	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
103690003609	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690003610	putative active site [active]
103690003611	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690003612	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690003613	P-loop; other site
103690003614	Magnesium ion binding site [ion binding]; other site
103690003615	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690003616	Magnesium ion binding site [ion binding]; other site
103690003617	Predicted transcriptional regulators [Transcription]; Region: COG1725
103690003618	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
103690003619	DNA-binding site [nucleotide binding]; DNA binding site
103690003620	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
103690003621	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
103690003622	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
103690003623	RNA binding site [nucleotide binding]; other site
103690003624	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
103690003625	RNA binding site [nucleotide binding]; other site
103690003626	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
103690003627	RNA binding site [nucleotide binding]; other site
103690003628	Ion channel; Region: Ion_trans_2; pfam07885
103690003629	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
103690003630	TrkA-N domain; Region: TrkA_N; pfam02254
103690003631	TrkA-C domain; Region: TrkA_C; pfam02080
103690003632	acetylornithine aminotransferase; Provisional; Region: PRK02627
103690003633	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
103690003634	inhibitor-cofactor binding pocket; inhibition site
103690003635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690003636	catalytic residue [active]
103690003637	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003639	binding surface
103690003640	TPR motif; other site
103690003641	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003642	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003644	binding surface
103690003645	TPR motif; other site
103690003646	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003647	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003648	binding surface
103690003649	TPR motif; other site
103690003650	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003651	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003652	Psb28 protein; Region: Psb28; pfam03912
103690003653	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cd00044
103690003654	catalytic site [active]
103690003655	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
103690003656	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003657	active site
103690003658	phosphorylation site [posttranslational modification]
103690003659	intermolecular recognition site; other site
103690003660	dimerization interface [polypeptide binding]; other site
103690003661	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
103690003662	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
103690003663	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
103690003664	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690003665	anti sigma factor interaction site; other site
103690003666	regulatory phosphorylation site [posttranslational modification]; other site
103690003667	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003668	GAF domain; Region: GAF_3; pfam13492
103690003669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690003670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003671	ATP binding site [chemical binding]; other site
103690003672	Mg2+ binding site [ion binding]; other site
103690003673	G-X-G motif; other site
103690003674	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690003675	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690003676	hypothetical protein; Reviewed; Region: PRK12275
103690003677	four helix bundle protein; Region: TIGR02436
103690003678	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
103690003679	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
103690003680	active site
103690003681	HIGH motif; other site
103690003682	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
103690003683	KMSKS motif; other site
103690003684	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
103690003685	tRNA binding surface [nucleotide binding]; other site
103690003686	anticodon binding site; other site
103690003687	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
103690003688	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690003689	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
103690003690	PBP superfamily domain; Region: PBP_like_2; cl17296
103690003691	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
103690003692	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
103690003693	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
103690003694	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
103690003695	arsenical-resistance protein; Region: acr3; TIGR00832
103690003696	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690003697	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690003698	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690003699	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690003700	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690003701	siderophore binding site; other site
103690003702	AMIN domain; Region: AMIN; pfam11741
103690003703	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690003704	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690003705	N-terminal plug; other site
103690003706	ligand-binding site [chemical binding]; other site
103690003707	Sodium Bile acid symporter family; Region: SBF; cl17470
103690003708	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690003709	dimerization interface [polypeptide binding]; other site
103690003710	putative DNA binding site [nucleotide binding]; other site
103690003711	putative Zn2+ binding site [ion binding]; other site
103690003712	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
103690003713	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690003714	putative metal binding site [ion binding]; other site
103690003715	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
103690003716	Low molecular weight phosphatase family; Region: LMWPc; cd00115
103690003717	active site
103690003718	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
103690003719	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
103690003720	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690003721	catalytic core [active]
103690003722	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
103690003723	Putative phosphatase (DUF442); Region: DUF442; cl17385
103690003724	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
103690003725	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
103690003726	Chromate transporter; Region: Chromate_transp; pfam02417
103690003727	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
103690003728	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
103690003729	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
103690003730	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
103690003731	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
103690003732	N-acetyl-D-glucosamine binding site [chemical binding]; other site
103690003733	catalytic residue [active]
103690003734	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
103690003735	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690003736	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690003737	P-loop; other site
103690003738	Magnesium ion binding site [ion binding]; other site
103690003739	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690003740	Magnesium ion binding site [ion binding]; other site
103690003741	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690003742	active site
103690003743	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690003744	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
103690003745	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690003746	CHASE2 domain; Region: CHASE2; pfam05226
103690003747	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
103690003748	cyclase homology domain; Region: CHD; cd07302
103690003749	nucleotidyl binding site; other site
103690003750	metal binding site [ion binding]; metal-binding site
103690003751	dimer interface [polypeptide binding]; other site
103690003752	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690003753	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
103690003754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003755	dimerization interface [polypeptide binding]; other site
103690003756	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003757	dimerization interface [polypeptide binding]; other site
103690003758	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003759	dimerization interface [polypeptide binding]; other site
103690003760	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
103690003761	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003762	dimerization interface [polypeptide binding]; other site
103690003763	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003764	dimerization interface [polypeptide binding]; other site
103690003765	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
103690003766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003767	dimerization interface [polypeptide binding]; other site
103690003768	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003769	dimerization interface [polypeptide binding]; other site
103690003770	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003771	dimerization interface [polypeptide binding]; other site
103690003772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690003773	dimerization interface [polypeptide binding]; other site
103690003774	GAF domain; Region: GAF_2; pfam13185
103690003775	GAF domain; Region: GAF; pfam01590
103690003776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003777	dimer interface [polypeptide binding]; other site
103690003778	phosphorylation site [posttranslational modification]
103690003779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003780	ATP binding site [chemical binding]; other site
103690003781	Mg2+ binding site [ion binding]; other site
103690003782	G-X-G motif; other site
103690003783	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003785	active site
103690003786	phosphorylation site [posttranslational modification]
103690003787	intermolecular recognition site; other site
103690003788	dimerization interface [polypeptide binding]; other site
103690003789	Response regulator receiver domain; Region: Response_reg; pfam00072
103690003790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003791	active site
103690003792	phosphorylation site [posttranslational modification]
103690003793	intermolecular recognition site; other site
103690003794	dimerization interface [polypeptide binding]; other site
103690003795	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003797	active site
103690003798	phosphorylation site [posttranslational modification]
103690003799	intermolecular recognition site; other site
103690003800	dimerization interface [polypeptide binding]; other site
103690003801	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690003802	Ligand Binding Site [chemical binding]; other site
103690003803	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690003804	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
103690003805	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
103690003806	C-terminal domain interface [polypeptide binding]; other site
103690003807	GSH binding site (G-site) [chemical binding]; other site
103690003808	dimer interface [polypeptide binding]; other site
103690003809	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
103690003810	N-terminal domain interface [polypeptide binding]; other site
103690003811	putative dimer interface [polypeptide binding]; other site
103690003812	active site
103690003813	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690003814	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690003815	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690003816	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690003817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690003818	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
103690003819	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
103690003820	Walker A/P-loop; other site
103690003821	ATP binding site [chemical binding]; other site
103690003822	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690003823	Q-loop/lid; other site
103690003824	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
103690003825	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
103690003826	ABC transporter signature motif; other site
103690003827	Walker B; other site
103690003828	D-loop; other site
103690003829	H-loop/switch region; other site
103690003830	PRC-barrel domain; Region: PRC; pfam05239
103690003831	PRC-barrel domain; Region: PRC; pfam05239
103690003832	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
103690003833	EF-hand domain pair; Region: EF_hand_5; pfam13499
103690003834	Ca2+ binding site [ion binding]; other site
103690003835	excinuclease ABC subunit B; Provisional; Region: PRK05298
103690003836	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690003837	ATP binding site [chemical binding]; other site
103690003838	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690003839	nucleotide binding region [chemical binding]; other site
103690003840	ATP-binding site [chemical binding]; other site
103690003841	Ultra-violet resistance protein B; Region: UvrB; pfam12344
103690003842	UvrB/uvrC motif; Region: UVR; pfam02151
103690003843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
103690003844	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
103690003845	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690003846	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690003847	active site
103690003848	metal binding site [ion binding]; metal-binding site
103690003849	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690003850	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690003851	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690003852	arogenate dehydrogenase; Reviewed; Region: PRK07417
103690003853	prephenate dehydrogenase; Validated; Region: PRK08507
103690003854	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690003855	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003856	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003857	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003858	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003859	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003860	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003861	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690003863	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
103690003864	PAS domain S-box; Region: sensory_box; TIGR00229
103690003865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690003866	putative active site [active]
103690003867	heme pocket [chemical binding]; other site
103690003868	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003869	GAF domain; Region: GAF; pfam01590
103690003870	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003871	dimer interface [polypeptide binding]; other site
103690003872	phosphorylation site [posttranslational modification]
103690003873	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003874	ATP binding site [chemical binding]; other site
103690003875	Mg2+ binding site [ion binding]; other site
103690003876	G-X-G motif; other site
103690003877	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690003878	G1 box; other site
103690003879	GTP/Mg2+ binding site [chemical binding]; other site
103690003880	G2 box; other site
103690003881	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
103690003882	Predicted integral membrane protein [Function unknown]; Region: COG5500
103690003883	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
103690003884	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
103690003885	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
103690003886	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
103690003887	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
103690003888	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
103690003889	catalytic motif [active]
103690003890	Catalytic residue [active]
103690003891	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
103690003892	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
103690003893	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
103690003894	catalytic site [active]
103690003895	subunit interface [polypeptide binding]; other site
103690003896	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690003897	anti sigma factor interaction site; other site
103690003898	regulatory phosphorylation site [posttranslational modification]; other site
103690003899	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690003900	Probable transposase; Region: OrfB_IS605; pfam01385
103690003901	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690003902	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
103690003903	dimerization interface [polypeptide binding]; other site
103690003904	active site
103690003905	metal binding site [ion binding]; metal-binding site
103690003906	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
103690003907	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
103690003908	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
103690003909	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
103690003910	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690003911	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
103690003912	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
103690003913	Uncharacterized conserved protein [Function unknown]; Region: COG3937
103690003914	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
103690003915	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
103690003916	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690003917	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690003918	Phage-related lysozyme (muraminidase) [General function prediction only]; Region: COG3772
103690003919	catalytic residue [active]
103690003920	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
103690003921	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
103690003922	dimer interface [polypeptide binding]; other site
103690003923	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690003924	catalytic residue [active]
103690003925	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690003926	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003927	active site
103690003928	phosphorylation site [posttranslational modification]
103690003929	intermolecular recognition site; other site
103690003930	dimerization interface [polypeptide binding]; other site
103690003931	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690003932	DNA binding site [nucleotide binding]
103690003933	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
103690003934	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003935	dimer interface [polypeptide binding]; other site
103690003936	phosphorylation site [posttranslational modification]
103690003937	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003938	ATP binding site [chemical binding]; other site
103690003939	Mg2+ binding site [ion binding]; other site
103690003940	G-X-G motif; other site
103690003941	Pirin-related protein [General function prediction only]; Region: COG1741
103690003942	Pirin; Region: Pirin; pfam02678
103690003943	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
103690003944	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
103690003945	dimerization interface [polypeptide binding]; other site
103690003946	DPS ferroxidase diiron center [ion binding]; other site
103690003947	ion pore; other site
103690003948	Rubrerythrin [Energy production and conversion]; Region: COG1592
103690003949	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
103690003950	binuclear metal center [ion binding]; other site
103690003951	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
103690003952	iron binding site [ion binding]; other site
103690003953	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690003954	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690003955	phosphopeptide binding site; other site
103690003956	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690003957	GAF domain; Region: GAF; pfam01590
103690003958	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690003959	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690003960	metal binding site [ion binding]; metal-binding site
103690003961	active site
103690003962	I-site; other site
103690003963	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690003964	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690003966	binding surface
103690003967	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690003968	TPR motif; other site
103690003969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690003970	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690003971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003972	active site
103690003973	phosphorylation site [posttranslational modification]
103690003974	intermolecular recognition site; other site
103690003975	dimerization interface [polypeptide binding]; other site
103690003976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003977	dimer interface [polypeptide binding]; other site
103690003978	phosphorylation site [posttranslational modification]
103690003979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003980	ATP binding site [chemical binding]; other site
103690003981	Mg2+ binding site [ion binding]; other site
103690003982	G-X-G motif; other site
103690003983	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690003984	CHASE2 domain; Region: CHASE2; pfam05226
103690003985	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690003986	dimer interface [polypeptide binding]; other site
103690003987	phosphorylation site [posttranslational modification]
103690003988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690003989	ATP binding site [chemical binding]; other site
103690003990	Mg2+ binding site [ion binding]; other site
103690003991	G-X-G motif; other site
103690003992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690003993	active site
103690003994	phosphorylation site [posttranslational modification]
103690003995	intermolecular recognition site; other site
103690003996	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690003997	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
103690003998	active site
103690003999	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
103690004000	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690004001	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690004002	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690004003	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
103690004004	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
103690004005	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690004006	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
103690004007	Prostaglandin dehydrogenases; Region: PGDH; cd05288
103690004008	NAD(P) binding site [chemical binding]; other site
103690004009	substrate binding site [chemical binding]; other site
103690004010	dimer interface [polypeptide binding]; other site
103690004011	EamA-like transporter family; Region: EamA; pfam00892
103690004012	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
103690004013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690004014	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690004015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004016	dimer interface [polypeptide binding]; other site
103690004017	phosphorylation site [posttranslational modification]
103690004018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004019	ATP binding site [chemical binding]; other site
103690004020	Mg2+ binding site [ion binding]; other site
103690004021	G-X-G motif; other site
103690004022	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004023	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004024	dimer interface [polypeptide binding]; other site
103690004025	phosphorylation site [posttranslational modification]
103690004026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004027	ATP binding site [chemical binding]; other site
103690004028	Mg2+ binding site [ion binding]; other site
103690004029	G-X-G motif; other site
103690004030	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690004031	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690004032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004033	active site
103690004034	phosphorylation site [posttranslational modification]
103690004035	intermolecular recognition site; other site
103690004036	dimerization interface [polypeptide binding]; other site
103690004037	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690004038	DNA binding site [nucleotide binding]
103690004039	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690004040	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690004041	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
103690004042	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
103690004043	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
103690004044	active site
103690004045	metal binding site [ion binding]; metal-binding site
103690004046	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690004047	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
103690004048	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690004049	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690004050	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
103690004051	putative active site [active]
103690004052	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690004053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690004054	Walker A/P-loop; other site
103690004055	ATP binding site [chemical binding]; other site
103690004056	Q-loop/lid; other site
103690004057	ABC transporter signature motif; other site
103690004058	Walker B; other site
103690004059	D-loop; other site
103690004060	H-loop/switch region; other site
103690004061	hydrolase, alpha/beta fold family protein; Region: PLN02824
103690004062	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
103690004063	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690004064	putative catalytic residue [active]
103690004065	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
103690004066	putative nucleotide binding site [chemical binding]; other site
103690004067	uridine monophosphate binding site [chemical binding]; other site
103690004068	homohexameric interface [polypeptide binding]; other site
103690004069	ribosome recycling factor; Reviewed; Region: frr; PRK00083
103690004070	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
103690004071	hinge region; other site
103690004072	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
103690004073	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690004074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690004075	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690004076	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
103690004077	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
103690004078	Protein of unknown function (DUF512); Region: DUF512; pfam04459
103690004079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690004080	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690004081	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690004082	Bacitracin resistance protein BacA; Region: BacA; pfam02673
103690004083	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
103690004084	Photosystem II 12 kDa extrinsic protein (PsbU); Region: PsbU; pfam06514
103690004085	L-aspartate oxidase; Provisional; Region: PRK07395
103690004086	L-aspartate oxidase; Provisional; Region: PRK06175
103690004087	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
103690004088	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690004089	CHASE2 domain; Region: CHASE2; pfam05226
103690004090	PAS domain S-box; Region: sensory_box; TIGR00229
103690004091	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004092	putative active site [active]
103690004093	heme pocket [chemical binding]; other site
103690004094	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690004095	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690004096	metal binding site [ion binding]; metal-binding site
103690004097	active site
103690004098	I-site; other site
103690004099	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
103690004100	substrate binding site [chemical binding]; other site
103690004101	putative active site [active]
103690004102	redox center [active]
103690004103	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
103690004104	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
103690004105	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
103690004106	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
103690004107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690004108	FeS/SAM binding site; other site
103690004109	TRAM domain; Region: TRAM; cl01282
103690004110	helicase 45; Provisional; Region: PTZ00424
103690004111	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
103690004112	ATP binding site [chemical binding]; other site
103690004113	Mg++ binding site [ion binding]; other site
103690004114	motif III; other site
103690004115	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690004116	nucleotide binding region [chemical binding]; other site
103690004117	ATP-binding site [chemical binding]; other site
103690004118	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690004119	putative active site [active]
103690004120	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690004121	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
103690004122	active site
103690004123	catalytic tetrad [active]
103690004124	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
103690004125	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
103690004126	FMN binding site [chemical binding]; other site
103690004127	active site
103690004128	catalytic residues [active]
103690004129	substrate binding site [chemical binding]; other site
103690004130	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
103690004131	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690004132	FOG: CBS domain [General function prediction only]; Region: COG0517
103690004133	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690004134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004135	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004136	putative active site [active]
103690004137	heme pocket [chemical binding]; other site
103690004138	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004139	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004140	putative active site [active]
103690004141	heme pocket [chemical binding]; other site
103690004142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004143	putative active site [active]
103690004144	heme pocket [chemical binding]; other site
103690004145	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690004146	GAF domain; Region: GAF; pfam01590
103690004147	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004148	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004149	putative active site [active]
103690004150	heme pocket [chemical binding]; other site
103690004151	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004152	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004153	putative active site [active]
103690004154	heme pocket [chemical binding]; other site
103690004155	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004156	putative active site [active]
103690004157	heme pocket [chemical binding]; other site
103690004158	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004159	PAS domain; Region: PAS_9; pfam13426
103690004160	putative active site [active]
103690004161	heme pocket [chemical binding]; other site
103690004162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004163	PAS fold; Region: PAS_3; pfam08447
103690004164	putative active site [active]
103690004165	heme pocket [chemical binding]; other site
103690004166	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004167	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004168	dimer interface [polypeptide binding]; other site
103690004169	phosphorylation site [posttranslational modification]
103690004170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004171	ATP binding site [chemical binding]; other site
103690004172	Mg2+ binding site [ion binding]; other site
103690004173	G-X-G motif; other site
103690004174	Response regulator receiver domain; Region: Response_reg; pfam00072
103690004175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004176	active site
103690004177	phosphorylation site [posttranslational modification]
103690004178	intermolecular recognition site; other site
103690004179	dimerization interface [polypeptide binding]; other site
103690004180	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690004181	Response regulator receiver domain; Region: Response_reg; pfam00072
103690004182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004183	active site
103690004184	phosphorylation site [posttranslational modification]
103690004185	intermolecular recognition site; other site
103690004186	dimerization interface [polypeptide binding]; other site
103690004187	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004188	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004189	phosphorylation site [posttranslational modification]
103690004190	dimer interface [polypeptide binding]; other site
103690004191	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004192	ATP binding site [chemical binding]; other site
103690004193	Mg2+ binding site [ion binding]; other site
103690004194	G-X-G motif; other site
103690004195	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690004196	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690004197	non-specific DNA binding site [nucleotide binding]; other site
103690004198	salt bridge; other site
103690004199	sequence-specific DNA binding site [nucleotide binding]; other site
103690004200	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690004201	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
103690004202	putative acyl-acceptor binding pocket; other site
103690004203	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
103690004204	Amidase; Region: Amidase; pfam01425
103690004205	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
103690004206	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
103690004207	catalytic residues [active]
103690004208	Clp protease; Region: CLP_protease; pfam00574
103690004209	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
103690004210	oligomer interface [polypeptide binding]; other site
103690004211	active site residues [active]
103690004212	Exoribonuclease R [Transcription]; Region: VacB; COG0557
103690004213	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
103690004214	RNB domain; Region: RNB; pfam00773
103690004215	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
103690004216	RNA binding site [nucleotide binding]; other site
103690004217	aromatic acid decarboxylase; Validated; Region: PRK05920
103690004218	Flavoprotein; Region: Flavoprotein; pfam02441
103690004219	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
103690004220	shikimate kinase; Reviewed; Region: aroK; PRK00131
103690004221	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
103690004222	ADP binding site [chemical binding]; other site
103690004223	magnesium binding site [ion binding]; other site
103690004224	putative shikimate binding site; other site
103690004225	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
103690004226	feedback inhibition sensing region; other site
103690004227	homohexameric interface [polypeptide binding]; other site
103690004228	nucleotide binding site [chemical binding]; other site
103690004229	N-acetyl-L-glutamate binding site [chemical binding]; other site
103690004230	Outer membrane lipoprotein; Region: YfiO; pfam13525
103690004231	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
103690004232	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
103690004233	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
103690004234	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
103690004235	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690004236	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690004237	Predicted membrane protein [Function unknown]; Region: COG4330
103690004238	DNA polymerase I; Provisional; Region: PRK05755
103690004239	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
103690004240	active site
103690004241	metal binding site 1 [ion binding]; metal-binding site
103690004242	putative 5' ssDNA interaction site; other site
103690004243	metal binding site 3; metal-binding site
103690004244	metal binding site 2 [ion binding]; metal-binding site
103690004245	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
103690004246	putative DNA binding site [nucleotide binding]; other site
103690004247	putative metal binding site [ion binding]; other site
103690004248	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
103690004249	active site
103690004250	catalytic site [active]
103690004251	substrate binding site [chemical binding]; other site
103690004252	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
103690004253	active site
103690004254	DNA binding site [nucleotide binding]
103690004255	catalytic site [active]
103690004256	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690004257	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
103690004258	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
103690004259	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
103690004260	homodimer interface [polypeptide binding]; other site
103690004261	substrate-cofactor binding pocket; other site
103690004262	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690004263	catalytic residue [active]
103690004264	FtsH Extracellular; Region: FtsH_ext; pfam06480
103690004265	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
103690004266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690004267	Walker A motif; other site
103690004268	ATP binding site [chemical binding]; other site
103690004269	Walker B motif; other site
103690004270	arginine finger; other site
103690004271	Peptidase family M41; Region: Peptidase_M41; pfam01434
103690004272	UV damage repair endonuclease [DNA replication, recombination, and repair]; Region: Uve; COG4294
103690004273	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
103690004274	rod shape-determining protein MreB; Provisional; Region: PRK13930
103690004275	nucleotide binding site [chemical binding]; other site
103690004276	putative NEF/HSP70 interaction site [polypeptide binding]; other site
103690004277	SBD interface [polypeptide binding]; other site
103690004278	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
103690004279	putative active site [active]
103690004280	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690004281	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690004282	Divergent AAA domain; Region: AAA_4; pfam04326
103690004283	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
103690004284	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
103690004285	substrate binding site [chemical binding]; other site
103690004286	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
103690004287	substrate binding site [chemical binding]; other site
103690004288	ligand binding site [chemical binding]; other site
103690004289	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
103690004290	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
103690004291	active site
103690004292	HIGH motif; other site
103690004293	dimer interface [polypeptide binding]; other site
103690004294	KMSKS motif; other site
103690004295	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
103690004296	TAP-like protein; Region: Abhydrolase_4; pfam08386
103690004297	Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328
103690004298	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
103690004299	putative homodimer interface [polypeptide binding]; other site
103690004300	putative active site pocket [active]
103690004301	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
103690004302	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
103690004303	putative trimer interface [polypeptide binding]; other site
103690004304	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
103690004305	putative CoA binding site [chemical binding]; other site
103690004306	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
103690004307	trimer interface [polypeptide binding]; other site
103690004308	active site
103690004309	substrate binding site [chemical binding]; other site
103690004310	CoA binding site [chemical binding]; other site
103690004311	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
103690004312	OstA-like protein; Region: OstA; cl00844
103690004313	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
103690004314	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690004315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004316	active site
103690004317	phosphorylation site [posttranslational modification]
103690004318	intermolecular recognition site; other site
103690004319	dimerization interface [polypeptide binding]; other site
103690004320	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690004321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004322	putative active site [active]
103690004323	heme pocket [chemical binding]; other site
103690004324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004325	dimer interface [polypeptide binding]; other site
103690004326	phosphorylation site [posttranslational modification]
103690004327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004328	ATP binding site [chemical binding]; other site
103690004329	Mg2+ binding site [ion binding]; other site
103690004330	G-X-G motif; other site
103690004331	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690004332	GAF domain; Region: GAF; pfam01590
103690004333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004334	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004335	putative active site [active]
103690004336	heme pocket [chemical binding]; other site
103690004337	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690004338	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004339	putative active site [active]
103690004340	heme pocket [chemical binding]; other site
103690004341	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690004342	putative active site [active]
103690004343	heme pocket [chemical binding]; other site
103690004344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690004345	GAF domain; Region: GAF; pfam01590
103690004346	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
103690004347	Histidine kinase; Region: HisKA_2; pfam07568
103690004348	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004349	ATP binding site [chemical binding]; other site
103690004350	Mg2+ binding site [ion binding]; other site
103690004351	G-X-G motif; other site
103690004352	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690004353	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004354	active site
103690004355	phosphorylation site [posttranslational modification]
103690004356	intermolecular recognition site; other site
103690004357	dimerization interface [polypeptide binding]; other site
103690004358	lipoyl synthase; Provisional; Region: PRK12928
103690004359	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690004360	FeS/SAM binding site; other site
103690004361	PsaX family; Region: PsaX; pfam08078
103690004362	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
103690004363	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
103690004364	TM-ABC transporter signature motif; other site
103690004365	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004367	dimer interface [polypeptide binding]; other site
103690004368	phosphorylation site [posttranslational modification]
103690004369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004370	ATP binding site [chemical binding]; other site
103690004371	Mg2+ binding site [ion binding]; other site
103690004372	G-X-G motif; other site
103690004373	Response regulator receiver domain; Region: Response_reg; pfam00072
103690004374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004375	active site
103690004376	phosphorylation site [posttranslational modification]
103690004377	intermolecular recognition site; other site
103690004378	dimerization interface [polypeptide binding]; other site
103690004379	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
103690004380	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
103690004381	Ligand Binding Site [chemical binding]; other site
103690004382	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
103690004383	active site
103690004384	catalytic triad [active]
103690004385	oxyanion hole [active]
103690004386	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
103690004387	DNA methylase; Region: N6_N4_Mtase; pfam01555
103690004388	cyanate hydratase; Validated; Region: PRK02866
103690004389	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
103690004390	oligomer interface [polypeptide binding]; other site
103690004391	active site
103690004392	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690004393	ABC transporter signature motif; other site
103690004394	Walker B; other site
103690004395	D-loop; other site
103690004396	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690004397	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
103690004398	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
103690004399	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
103690004400	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
103690004401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690004402	Walker A/P-loop; other site
103690004403	ATP binding site [chemical binding]; other site
103690004404	Q-loop/lid; other site
103690004405	ABC transporter signature motif; other site
103690004406	Walker B; other site
103690004407	D-loop; other site
103690004408	H-loop/switch region; other site
103690004409	ABC transporter; Region: ABC_tran_2; pfam12848
103690004410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
103690004411	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690004412	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690004413	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
103690004414	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
103690004415	intersubunit interface [polypeptide binding]; other site
103690004416	ATP-grasp domain; Region: ATP-grasp; pfam02222
103690004417	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
103690004418	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
103690004419	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690004420	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
103690004421	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
103690004422	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
103690004423	Sulfate transporter family; Region: Sulfate_transp; pfam00916
103690004424	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
103690004425	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
103690004426	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690004427	GAF domain; Region: GAF_3; pfam13492
103690004428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004429	dimer interface [polypeptide binding]; other site
103690004430	phosphorylation site [posttranslational modification]
103690004431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004432	ATP binding site [chemical binding]; other site
103690004433	Mg2+ binding site [ion binding]; other site
103690004434	G-X-G motif; other site
103690004435	NifU-like domain; Region: NifU; pfam01106
103690004436	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
103690004437	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
103690004438	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
103690004439	putative active site [active]
103690004440	catalytic site [active]
103690004441	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690004442	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690004443	active site
103690004444	ATP binding site [chemical binding]; other site
103690004445	substrate binding site [chemical binding]; other site
103690004446	activation loop (A-loop); other site
103690004447	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
103690004448	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
103690004449	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690004450	FeS/SAM binding site; other site
103690004451	TRAM domain; Region: TRAM; pfam01938
103690004452	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
103690004453	tartrate dehydrogenase; Region: TTC; TIGR02089
103690004454	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
103690004455	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
103690004456	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
103690004457	Predicted membrane protein [Function unknown]; Region: COG5305
103690004458	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
103690004459	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
103690004460	active site
103690004461	HIGH motif; other site
103690004462	nucleotide binding site [chemical binding]; other site
103690004463	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
103690004464	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
103690004465	active site
103690004466	KMSKS motif; other site
103690004467	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
103690004468	tRNA binding surface [nucleotide binding]; other site
103690004469	anticodon binding site; other site
103690004470	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
103690004471	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
103690004472	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
103690004473	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
103690004474	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
103690004475	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690004476	Fasciclin domain; Region: Fasciclin; pfam02469
103690004477	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690004478	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690004479	Coenzyme A binding pocket [chemical binding]; other site
103690004480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
103690004481	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004482	binding surface
103690004483	TPR motif; other site
103690004484	TPR repeat; Region: TPR_11; pfam13414
103690004485	TPR repeat; Region: TPR_11; pfam13414
103690004486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004487	binding surface
103690004488	TPR motif; other site
103690004489	TPR repeat; Region: TPR_11; pfam13414
103690004490	DNA primase; Validated; Region: dnaG; PRK05667
103690004491	CHC2 zinc finger; Region: zf-CHC2; pfam01807
103690004492	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
103690004493	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
103690004494	active site
103690004495	metal binding site [ion binding]; metal-binding site
103690004496	interdomain interaction site; other site
103690004497	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690004498	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690004499	active site
103690004500	metal binding site [ion binding]; metal-binding site
103690004501	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
103690004502	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
103690004503	DNA protecting protein DprA; Region: dprA; TIGR00732
103690004504	Uncharacterized integral membrane protein [Function unknown]; Region: COG5413
103690004505	Uncharacterized conserved protein [Function unknown]; Region: COG1912
103690004506	Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555
103690004507	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690004508	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690004509	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690004510	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
103690004511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690004512	dimer interface [polypeptide binding]; other site
103690004513	conserved gate region; other site
103690004514	putative PBP binding loops; other site
103690004515	ABC-ATPase subunit interface; other site
103690004516	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690004517	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690004518	active site
103690004519	ATP binding site [chemical binding]; other site
103690004520	substrate binding site [chemical binding]; other site
103690004521	activation loop (A-loop); other site
103690004522	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690004523	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690004524	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
103690004525	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
103690004526	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
103690004527	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
103690004528	thiamine phosphate binding site [chemical binding]; other site
103690004529	active site
103690004530	pyrophosphate binding site [ion binding]; other site
103690004531	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
103690004532	thiS-thiF/thiG interaction site; other site
103690004533	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690004534	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690004535	Predicted membrane protein [Function unknown]; Region: COG4371
103690004536	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
103690004537	ferredoxin-sulfite reductase; Region: sir; TIGR02042
103690004538	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690004539	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
103690004540	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
103690004541	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690004542	Lipase (class 2); Region: Lipase_2; pfam01674
103690004543	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
103690004544	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690004545	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690004546	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
103690004547	hydroxyglutarate oxidase; Provisional; Region: PRK11728
103690004548	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
103690004549	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
103690004550	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
103690004551	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
103690004552	diiron binding motif [ion binding]; other site
103690004553	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
103690004554	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
103690004555	Cytochrome P450; Region: p450; pfam00067
103690004556	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690004557	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
103690004558	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690004559	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
103690004560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004561	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
103690004562	TPR motif; other site
103690004563	binding surface
103690004564	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690004565	TPR motif; other site
103690004566	binding surface
103690004567	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
103690004568	Cytochrome c; Region: Cytochrom_C; pfam00034
103690004569	cytochrome b6-f complex subunit PetG; Reviewed; Region: petG; PRK00665
103690004570	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
103690004571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690004572	S-adenosylmethionine binding site [chemical binding]; other site
103690004573	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
103690004574	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
103690004575	putative active site [active]
103690004576	oxyanion strand; other site
103690004577	catalytic triad [active]
103690004578	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
103690004579	putative substrate binding pocket [chemical binding]; other site
103690004580	catalytic triad [active]
103690004581	AB domain interface; other site
103690004582	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
103690004583	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
103690004584	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
103690004585	nucleotide binding site [chemical binding]; other site
103690004586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295
103690004587	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
103690004588	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
103690004589	2TM domain; Region: 2TM; pfam13239
103690004590	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690004591	CHAT domain; Region: CHAT; cl17868
103690004592	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690004593	CHASE2 domain; Region: CHASE2; pfam05226
103690004594	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690004595	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
103690004596	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
103690004597	active site
103690004598	catalytic triad [active]
103690004599	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
103690004600	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
103690004601	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
103690004602	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
103690004603	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
103690004604	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690004605	dimer interface [polypeptide binding]; other site
103690004606	conserved gate region; other site
103690004607	putative PBP binding loops; other site
103690004608	ABC-ATPase subunit interface; other site
103690004609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690004610	dimer interface [polypeptide binding]; other site
103690004611	conserved gate region; other site
103690004612	putative PBP binding loops; other site
103690004613	ABC-ATPase subunit interface; other site
103690004614	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
103690004615	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690004616	Walker A/P-loop; other site
103690004617	ATP binding site [chemical binding]; other site
103690004618	Q-loop/lid; other site
103690004619	ABC transporter signature motif; other site
103690004620	Walker B; other site
103690004621	D-loop; other site
103690004622	H-loop/switch region; other site
103690004623	Predicted membrane protein [Function unknown]; Region: COG4280
103690004624	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
103690004625	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
103690004626	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
103690004627	Phosphoesterase family; Region: Phosphoesterase; pfam04185
103690004628	Uncharacterized conserved protein [Function unknown]; Region: COG3391
103690004629	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690004630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004631	active site
103690004632	phosphorylation site [posttranslational modification]
103690004633	intermolecular recognition site; other site
103690004634	dimerization interface [polypeptide binding]; other site
103690004635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004636	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690004637	dimer interface [polypeptide binding]; other site
103690004638	phosphorylation site [posttranslational modification]
103690004639	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004640	ATP binding site [chemical binding]; other site
103690004641	Mg2+ binding site [ion binding]; other site
103690004642	G-X-G motif; other site
103690004643	Cache domain; Region: Cache_1; pfam02743
103690004644	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690004645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690004646	dimer interface [polypeptide binding]; other site
103690004647	phosphorylation site [posttranslational modification]
103690004648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690004649	ATP binding site [chemical binding]; other site
103690004650	Mg2+ binding site [ion binding]; other site
103690004651	G-X-G motif; other site
103690004652	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690004653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690004654	active site
103690004655	phosphorylation site [posttranslational modification]
103690004656	intermolecular recognition site; other site
103690004657	dimerization interface [polypeptide binding]; other site
103690004658	PEP-CTERM family integral membrane protein; Region: PEP_integral; TIGR02921
103690004659	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
103690004660	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
103690004661	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690004662	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690004663	non-specific DNA binding site [nucleotide binding]; other site
103690004664	salt bridge; other site
103690004665	sequence-specific DNA binding site [nucleotide binding]; other site
103690004666	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
103690004667	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
103690004668	GatB domain; Region: GatB_Yqey; pfam02637
103690004669	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690004670	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690004671	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690004672	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004673	binding surface
103690004674	TPR motif; other site
103690004675	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004676	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690004678	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
103690004679	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690004680	putative active site [active]
103690004681	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690004682	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
103690004683	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
103690004684	trimer interface [polypeptide binding]; other site
103690004685	active site
103690004686	substrate binding site [chemical binding]; other site
103690004687	CoA binding site [chemical binding]; other site
103690004688	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
103690004689	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
103690004690	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
103690004691	active site
103690004692	catalytic residues [active]
103690004693	metal binding site [ion binding]; metal-binding site
103690004694	NifZ domain; Region: NifZ; pfam04319
103690004695	Nitrogen fixation protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NifU; COG5554
103690004696	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
103690004697	dimer interface [polypeptide binding]; other site
103690004698	[2Fe-2S] cluster binding site [ion binding]; other site
103690004699	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690004700	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690004701	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
103690004702	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
103690004703	homotetramer interface [polypeptide binding]; other site
103690004704	ligand binding site [chemical binding]; other site
103690004705	catalytic site [active]
103690004706	NAD binding site [chemical binding]; other site
103690004707	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
103690004708	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
103690004709	substrate binding site [chemical binding]; other site
103690004710	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
103690004711	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
103690004712	substrate binding site [chemical binding]; other site
103690004713	ligand binding site [chemical binding]; other site
103690004714	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332
103690004715	short chain dehydrogenase; Provisional; Region: PRK06181
103690004716	NADP binding site [chemical binding]; other site
103690004717	homodimer interface [polypeptide binding]; other site
103690004718	substrate binding site [chemical binding]; other site
103690004719	active site
103690004720	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
103690004721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690004722	S-adenosylmethionine binding site [chemical binding]; other site
103690004723	C factor cell-cell signaling protein; Provisional; Region: PRK09009
103690004724	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
103690004725	NADP binding site [chemical binding]; other site
103690004726	homodimer interface [polypeptide binding]; other site
103690004727	active site
103690004728	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690004729	non-specific DNA binding site [nucleotide binding]; other site
103690004730	salt bridge; other site
103690004731	sequence-specific DNA binding site [nucleotide binding]; other site
103690004732	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
103690004733	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
103690004734	nickel binding site [ion binding]; other site
103690004735	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
103690004736	NADPH bind site [chemical binding]; other site
103690004737	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
103690004738	putative FMN binding site [chemical binding]; other site
103690004739	NADPH bind site [chemical binding]; other site
103690004740	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690004741	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690004742	FOG: CBS domain [General function prediction only]; Region: COG0517
103690004743	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
103690004744	CP12 domain; Region: CP12; smart01093
103690004745	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
103690004746	FeoA domain; Region: FeoA; pfam04023
103690004747	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690004748	catalytic loop [active]
103690004749	iron binding site [ion binding]; other site
103690004750	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
103690004751	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
103690004752	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
103690004753	ATP binding site [chemical binding]; other site
103690004754	substrate interface [chemical binding]; other site
103690004755	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
103690004756	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5420
103690004757	Protein of unknown function, DUF269; Region: DUF269; pfam03270
103690004758	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
103690004759	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
103690004760	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
103690004761	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
103690004762	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
103690004763	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690004764	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
103690004765	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
103690004766	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
103690004767	MoFe protein beta/alpha subunit interactions; other site
103690004768	Beta subunit P cluster binding residues; other site
103690004769	MoFe protein beta subunit/Fe protein contacts; other site
103690004770	MoFe protein dimer/ dimer interactions; other site
103690004771	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
103690004772	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
103690004773	MoFe protein alpha/beta subunit interactions; other site
103690004774	Alpha subunit P cluster binding residues; other site
103690004775	FeMoco binding residues [chemical binding]; other site
103690004776	MoFe protein alpha subunit/Fe protein contacts; other site
103690004777	MoFe protein dimer/ dimer interactions; other site
103690004778	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690004779	active site
103690004780	catalytic residues [active]
103690004781	DNA binding site [nucleotide binding]
103690004782	Int/Topo IB signature motif; other site
103690004783	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
103690004784	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690004785	putative active site [active]
103690004786	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690004787	putative active site [active]
103690004788	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
103690004789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
103690004790	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690004791	Cytochrome P450; Region: p450; pfam00067
103690004792	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690004793	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690004794	active site
103690004795	nitrogenase reductase; Reviewed; Region: PRK13236
103690004796	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
103690004797	Nucleotide-binding sites [chemical binding]; other site
103690004798	Walker A motif; other site
103690004799	Switch I region of nucleotide binding site; other site
103690004800	Fe4S4 binding sites [ion binding]; other site
103690004801	Switch II region of nucleotide binding site; other site
103690004802	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
103690004803	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
103690004804	trimerization site [polypeptide binding]; other site
103690004805	active site
103690004806	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
103690004807	NifU-like domain; Region: NifU; pfam01106
103690004808	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
103690004809	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
103690004810	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690004811	catalytic residue [active]
103690004812	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
103690004813	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
103690004814	catalytic residues [active]
103690004815	catalytic nucleophile [active]
103690004816	Presynaptic Site I dimer interface [polypeptide binding]; other site
103690004817	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
103690004818	Synaptic Flat tetramer interface [polypeptide binding]; other site
103690004819	Synaptic Site I dimer interface [polypeptide binding]; other site
103690004820	DNA binding site [nucleotide binding]
103690004821	Recombinase; Region: Recombinase; pfam07508
103690004822	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
103690004823	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690004824	putative active site [active]
103690004825	XisH protein; Region: XisH; pfam08814
103690004826	XisI protein; Region: XisI; pfam08869
103690004827	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690004828	DNA binding site [nucleotide binding]
103690004829	active site
103690004830	Int/Topo IB signature motif; other site
103690004831	catalytic residues [active]
103690004832	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004833	CHAT domain; Region: CHAT; pfam12770
103690004834	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004836	binding surface
103690004837	TPR motif; other site
103690004838	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004839	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004840	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004841	binding surface
103690004842	TPR motif; other site
103690004843	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004844	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004845	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690004846	binding surface
103690004847	TPR motif; other site
103690004848	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690004849	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690004850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690004851	non-specific DNA binding site [nucleotide binding]; other site
103690004852	salt bridge; other site
103690004853	sequence-specific DNA binding site [nucleotide binding]; other site
103690004854	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
103690004855	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690004856	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
103690004857	putative active site [active]
103690004858	putative NTP binding site [chemical binding]; other site
103690004859	putative nucleic acid binding site [nucleotide binding]; other site
103690004860	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
103690004861	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
103690004862	CRISPR system related protein, RAMP superfamily [Defense    mechanisms]; Region: COG1337
103690004863	CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cd09683
103690004864	CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cd09700
103690004865	CRISPR system related protein, RAMP superfamily [Defense    mechanisms]; Region: COG1337
103690004866	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
103690004867	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
103690004868	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
103690004869	putative phosphoketolase; Provisional; Region: PRK05261
103690004870	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
103690004871	TPP-binding site; other site
103690004872	XFP C-terminal domain; Region: XFP_C; pfam09363
103690004873	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
103690004874	active site
103690004875	dimerization interface [polypeptide binding]; other site
103690004876	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
103690004877	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
103690004878	chaperone protein DnaJ; Provisional; Region: PRK14299
103690004879	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690004880	HSP70 interaction site [polypeptide binding]; other site
103690004881	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
103690004882	substrate binding site [polypeptide binding]; other site
103690004883	dimer interface [polypeptide binding]; other site
103690004884	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690004885	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
103690004886	Walker A/P-loop; other site
103690004887	ATP binding site [chemical binding]; other site
103690004888	Q-loop/lid; other site
103690004889	ABC transporter signature motif; other site
103690004890	Walker B; other site
103690004891	D-loop; other site
103690004892	H-loop/switch region; other site
103690004893	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690004894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690004895	Walker A/P-loop; other site
103690004896	ATP binding site [chemical binding]; other site
103690004897	Q-loop/lid; other site
103690004898	ABC transporter signature motif; other site
103690004899	Walker B; other site
103690004900	D-loop; other site
103690004901	H-loop/switch region; other site
103690004902	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
103690004903	ABC-2 type transporter; Region: ABC2_membrane; cl17235
103690004904	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690004905	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
103690004906	oligomeric interface; other site
103690004907	putative active site [active]
103690004908	homodimer interface [polypeptide binding]; other site
103690004909	PspC domain; Region: PspC; pfam04024
103690004910	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
103690004911	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
103690004912	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
103690004913	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690004914	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690004915	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690004916	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690004917	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690004918	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690004919	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
103690004920	FtsX-like permease family; Region: FtsX; pfam02687
103690004921	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
103690004922	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690004923	Walker A/P-loop; other site
103690004924	ATP binding site [chemical binding]; other site
103690004925	Q-loop/lid; other site
103690004926	ABC transporter signature motif; other site
103690004927	Walker B; other site
103690004928	D-loop; other site
103690004929	H-loop/switch region; other site
103690004930	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
103690004931	active site residue [active]
103690004932	Predicted permeases [General function prediction only]; Region: COG0701
103690004933	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
103690004934	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
103690004935	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
103690004936	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
103690004937	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
103690004938	cytochrome b subunit interaction site [polypeptide binding]; other site
103690004939	[2Fe-2S] cluster binding site [ion binding]; other site
103690004940	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
103690004941	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690004942	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690004943	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
103690004944	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
103690004945	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690004946	FeS/SAM binding site; other site
103690004947	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
103690004948	amino acid transporter; Region: 2A0306; TIGR00909
103690004949	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690004950	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690004951	S-adenosylmethionine binding site [chemical binding]; other site
103690004952	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
103690004953	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
103690004954	oligomerization interface [polypeptide binding]; other site
103690004955	active site
103690004956	metal binding site [ion binding]; metal-binding site
103690004957	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
103690004958	Two component regulator propeller; Region: Reg_prop; pfam07494
103690004959	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
103690004960	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
103690004961	homodimer interface [polypeptide binding]; other site
103690004962	active site
103690004963	heterodimer interface [polypeptide binding]; other site
103690004964	catalytic residue [active]
103690004965	metal binding site [ion binding]; metal-binding site
103690004966	RbcX protein; Region: RcbX; pfam02341
103690004967	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
103690004968	multimerization interface [polypeptide binding]; other site
103690004969	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
103690004970	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
103690004971	active site
103690004972	catalytic triad [active]
103690004973	oxyanion hole [active]
103690004974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690004975	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690004976	Probable transposase; Region: OrfB_IS605; pfam01385
103690004977	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690004978	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
103690004979	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
103690004980	putative multimerization interface [polypeptide binding]; other site
103690004981	Electron transfer DM13; Region: DM13; pfam10517
103690004982	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690004983	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690004984	Putative restriction endonuclease; Region: Uma2; pfam05685
103690004985	putative active site [active]
103690004986	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
103690004987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690004988	Coenzyme A binding pocket [chemical binding]; other site
103690004989	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
103690004990	EamA-like transporter family; Region: EamA; pfam00892
103690004991	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
103690004992	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690004993	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
103690004994	catalytic triad [active]
103690004995	dimer interface [polypeptide binding]; other site
103690004996	Glutaredoxin (GRX) family, PRX5 hybrid subfamily; composed of hybrid proteins containing peroxiredoxin (PRX) and GRX domains, which is found in some pathogenic bacteria and cyanobacteria. PRXs are thiol-specific antioxidant (TSA) proteins that confer a...; Region: GRX_hybridPRX5; cd03029
103690004997	GSH binding site [chemical binding]; other site
103690004998	catalytic residues [active]
103690004999	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
103690005000	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
103690005001	RNA binding site [nucleotide binding]; other site
103690005002	active site
103690005003	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
103690005004	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
103690005005	SnoaL-like domain; Region: SnoaL_2; pfam12680
103690005006	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
103690005007	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
103690005008	Walker A/P-loop; other site
103690005009	ATP binding site [chemical binding]; other site
103690005010	Q-loop/lid; other site
103690005011	ABC transporter signature motif; other site
103690005012	Walker B; other site
103690005013	D-loop; other site
103690005014	H-loop/switch region; other site
103690005015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005016	binding surface
103690005017	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690005018	TPR motif; other site
103690005019	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
103690005020	HD domain; Region: HD_4; pfam13328
103690005021	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
103690005022	synthetase active site [active]
103690005023	NTP binding site [chemical binding]; other site
103690005024	metal binding site [ion binding]; metal-binding site
103690005025	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
103690005026	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
103690005027	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690005028	dimerization interface [polypeptide binding]; other site
103690005029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005031	dimer interface [polypeptide binding]; other site
103690005032	phosphorylation site [posttranslational modification]
103690005033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005034	ATP binding site [chemical binding]; other site
103690005035	Mg2+ binding site [ion binding]; other site
103690005036	G-X-G motif; other site
103690005037	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
103690005038	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
103690005039	Walker A/P-loop; other site
103690005040	ATP binding site [chemical binding]; other site
103690005041	Q-loop/lid; other site
103690005042	ABC transporter signature motif; other site
103690005043	Walker B; other site
103690005044	D-loop; other site
103690005045	H-loop/switch region; other site
103690005046	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
103690005047	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
103690005048	Walker A/P-loop; other site
103690005049	ATP binding site [chemical binding]; other site
103690005050	Q-loop/lid; other site
103690005051	ABC transporter signature motif; other site
103690005052	Walker B; other site
103690005053	D-loop; other site
103690005054	H-loop/switch region; other site
103690005055	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
103690005056	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690005057	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690005058	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690005059	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690005060	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690005061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690005062	Walker A/P-loop; other site
103690005063	ATP binding site [chemical binding]; other site
103690005064	Q-loop/lid; other site
103690005065	ABC transporter signature motif; other site
103690005066	Walker B; other site
103690005067	D-loop; other site
103690005068	H-loop/switch region; other site
103690005069	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
103690005070	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
103690005071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690005072	dimer interface [polypeptide binding]; other site
103690005073	conserved gate region; other site
103690005074	putative PBP binding loops; other site
103690005075	ABC-ATPase subunit interface; other site
103690005076	WYL domain; Region: WYL; pfam13280
103690005077	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690005078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
103690005079	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
103690005080	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
103690005081	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
103690005082	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
103690005083	CRISPR/Cas system-associated protein Cas3; Distinct diverged subfamily of Cas3 helicase domain; Region: Cas3_I-D; cd09710
103690005084	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
103690005085	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
103690005086	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
103690005087	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
103690005088	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
103690005089	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690005090	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690005091	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
103690005092	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
103690005093	TIR domain; Region: TIR_2; pfam13676
103690005094	TIR domain; Region: TIR_2; pfam13676
103690005095	TIR domain; Region: TIR_2; pfam13676
103690005096	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690005097	CHASE2 domain; Region: CHASE2; pfam05226
103690005098	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
103690005099	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
103690005100	Ferritin-like; Region: Ferritin-like; pfam12902
103690005101	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
103690005102	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690005103	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005104	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005105	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005106	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005107	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005108	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
103690005109	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
103690005110	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
103690005111	SnoaL-like domain; Region: SnoaL_3; pfam13474
103690005112	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
103690005113	Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250
103690005114	C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851
103690005115	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
103690005116	Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430
103690005117	Domain interface; other site
103690005118	glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535
103690005119	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
103690005120	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
103690005121	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
103690005122	dimerization interface [polypeptide binding]; other site
103690005123	domain crossover interface; other site
103690005124	redox-dependent activation switch; other site
103690005125	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690005126	Ligand Binding Site [chemical binding]; other site
103690005127	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
103690005128	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
103690005129	NAD binding site [chemical binding]; other site
103690005130	dimerization interface [polypeptide binding]; other site
103690005131	product binding site; other site
103690005132	substrate binding site [chemical binding]; other site
103690005133	zinc binding site [ion binding]; other site
103690005134	catalytic residues [active]
103690005135	ribosomal protein S20; Region: rps20; CHL00102
103690005136	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
103690005137	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
103690005138	active site
103690005139	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
103690005140	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
103690005141	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
103690005142	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
103690005143	RPB10 interaction site [polypeptide binding]; other site
103690005144	RPB1 interaction site [polypeptide binding]; other site
103690005145	RPB11 interaction site [polypeptide binding]; other site
103690005146	RPB3 interaction site [polypeptide binding]; other site
103690005147	RPB12 interaction site [polypeptide binding]; other site
103690005148	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
103690005149	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
103690005150	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
103690005151	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
103690005152	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
103690005153	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
103690005154	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
103690005155	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
103690005156	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
103690005157	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
103690005158	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
103690005159	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
103690005160	DNA binding site [nucleotide binding]
103690005161	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
103690005162	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
103690005163	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
103690005164	putative di-iron ligands [ion binding]; other site
103690005165	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
103690005166	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
103690005167	putative di-iron ligands [ion binding]; other site
103690005168	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
103690005169	Fatty acid desaturase; Region: FA_desaturase; pfam00487
103690005170	Di-iron ligands [ion binding]; other site
103690005171	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
103690005172	Aluminium resistance protein; Region: Alum_res; pfam06838
103690005173	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
103690005174	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
103690005175	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
103690005176	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
103690005177	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
103690005178	putative active site [active]
103690005179	Double zinc ribbon; Region: DZR; pfam12773
103690005180	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
103690005181	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690005182	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690005183	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690005184	phosphopeptide binding site; other site
103690005185	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
103690005186	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
103690005187	Stage II sporulation protein; Region: SpoIID; pfam08486
103690005188	Probable transposase; Region: OrfB_IS605; pfam01385
103690005189	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690005190	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
103690005191	Nepovirus coat protein, C-terminal domain; Region: Nepo_coat_C; pfam03688
103690005192	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690005193	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690005194	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
103690005195	Haemolytic domain; Region: Haemolytic; pfam01809
103690005196	Predicted membrane protein [Function unknown]; Region: COG1836
103690005197	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690005198	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
103690005199	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690005200	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
103690005201	putative active site [active]
103690005202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690005203	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690005204	Walker A/P-loop; other site
103690005205	ATP binding site [chemical binding]; other site
103690005206	Q-loop/lid; other site
103690005207	ABC transporter signature motif; other site
103690005208	Walker B; other site
103690005209	D-loop; other site
103690005210	H-loop/switch region; other site
103690005211	CARDB; Region: CARDB; pfam07705
103690005212	Uncharacterized conserved protein [Function unknown]; Region: COG1572
103690005213	CARDB; Region: CARDB; pfam07705
103690005214	CARDB; Region: CARDB; pfam07705
103690005215	CARDB; Region: CARDB; pfam07705
103690005216	CARDB; Region: CARDB; pfam07705
103690005217	CARDB; Region: CARDB; pfam07705
103690005218	CARDB; Region: CARDB; pfam07705
103690005219	CARDB; Region: CARDB; pfam07705
103690005220	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
103690005221	catalytic triad [active]
103690005222	putative active site [active]
103690005223	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
103690005224	S-layer homology domain; Region: SLH; pfam00395
103690005225	S-layer homology domain; Region: SLH; pfam00395
103690005226	S-layer homology domain; Region: SLH; pfam00395
103690005227	S-layer homology domain; Region: SLH; pfam00395
103690005228	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690005229	putative active site [active]
103690005230	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690005231	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
103690005232	Walker A/P-loop; other site
103690005233	ATP binding site [chemical binding]; other site
103690005234	Q-loop/lid; other site
103690005235	ABC transporter signature motif; other site
103690005236	Walker B; other site
103690005237	D-loop; other site
103690005238	H-loop/switch region; other site
103690005239	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
103690005240	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
103690005241	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
103690005242	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
103690005243	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
103690005244	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
103690005245	putative active site [active]
103690005246	putative substrate binding site [chemical binding]; other site
103690005247	putative cosubstrate binding site; other site
103690005248	catalytic site [active]
103690005249	Protein kinase domain; Region: Pkinase; pfam00069
103690005250	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690005251	active site
103690005252	ATP binding site [chemical binding]; other site
103690005253	substrate binding site [chemical binding]; other site
103690005254	activation loop (A-loop); other site
103690005255	AAA ATPase domain; Region: AAA_16; pfam13191
103690005256	Predicted ATPase [General function prediction only]; Region: COG3899
103690005257	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690005258	GAF domain; Region: GAF; pfam01590
103690005259	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005261	ATP binding site [chemical binding]; other site
103690005262	Mg2+ binding site [ion binding]; other site
103690005263	G-X-G motif; other site
103690005264	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690005265	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690005266	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690005267	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690005268	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
103690005269	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
103690005270	metal-binding site [ion binding]
103690005271	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690005272	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690005273	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
103690005274	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
103690005275	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
103690005276	DNA binding residues [nucleotide binding]
103690005277	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
103690005278	dimer interface [polypeptide binding]; other site
103690005279	metal binding site [ion binding]; metal-binding site
103690005280	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
103690005281	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
103690005282	Sulfate transporter family; Region: Sulfate_transp; pfam00916
103690005283	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
103690005284	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690005285	Ligand Binding Site [chemical binding]; other site
103690005286	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690005287	Ligand Binding Site [chemical binding]; other site
103690005288	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
103690005289	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
103690005290	Sulfate transporter family; Region: Sulfate_transp; pfam00916
103690005291	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
103690005292	NB-ARC domain; Region: NB-ARC; pfam00931
103690005293	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
103690005294	MoaE homodimer interface [polypeptide binding]; other site
103690005295	MoaD interaction [polypeptide binding]; other site
103690005296	active site residues [active]
103690005297	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005298	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005299	ATP binding site [chemical binding]; other site
103690005300	Mg2+ binding site [ion binding]; other site
103690005301	G-X-G motif; other site
103690005302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005303	Response regulator receiver domain; Region: Response_reg; pfam00072
103690005304	active site
103690005305	phosphorylation site [posttranslational modification]
103690005306	intermolecular recognition site; other site
103690005307	dimerization interface [polypeptide binding]; other site
103690005308	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690005309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005310	active site
103690005311	phosphorylation site [posttranslational modification]
103690005312	intermolecular recognition site; other site
103690005313	dimerization interface [polypeptide binding]; other site
103690005314	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690005315	Major Facilitator Superfamily; Region: MFS_1; pfam07690
103690005316	putative substrate translocation pore; other site
103690005317	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
103690005318	FMN binding site [chemical binding]; other site
103690005319	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
103690005320	substrate binding site [chemical binding]; other site
103690005321	putative catalytic residue [active]
103690005322	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
103690005323	active site
103690005324	Acyl transferase domain; Region: Acyl_transf_1; cl08282
103690005325	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
103690005326	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
103690005327	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
103690005328	active site 1 [active]
103690005329	dimer interface [polypeptide binding]; other site
103690005330	active site 2 [active]
103690005331	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
103690005332	active site 1 [active]
103690005333	dimer interface [polypeptide binding]; other site
103690005334	active site 2 [active]
103690005335	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
103690005336	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690005337	putative NADP binding site [chemical binding]; other site
103690005338	active site
103690005339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690005340	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690005341	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690005342	active site
103690005343	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690005344	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690005345	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
103690005346	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
103690005347	acyl-activating enzyme (AAE) consensus motif; other site
103690005348	AMP binding site [chemical binding]; other site
103690005349	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
103690005350	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690005351	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690005352	active site
103690005353	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690005354	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690005355	Condensation domain; Region: Condensation; pfam00668
103690005356	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690005357	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690005358	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690005359	active site
103690005360	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690005361	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
103690005362	KR domain; Region: KR; pfam08659
103690005363	putative NADP binding site [chemical binding]; other site
103690005364	active site
103690005365	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690005366	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690005367	PAS fold; Region: PAS; pfam00989
103690005368	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690005369	putative active site [active]
103690005370	heme pocket [chemical binding]; other site
103690005371	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690005372	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690005373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690005374	aspartate aminotransferase; Provisional; Region: PRK06348
103690005375	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690005376	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
103690005377	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690005378	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
103690005379	Protein export membrane protein; Region: SecD_SecF; cl14618
103690005380	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690005381	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
103690005382	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
103690005383	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690005384	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
103690005385	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
103690005386	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690005387	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690005388	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
103690005389	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
103690005390	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005391	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005392	dimer interface [polypeptide binding]; other site
103690005393	phosphorylation site [posttranslational modification]
103690005394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005395	ATP binding site [chemical binding]; other site
103690005396	Mg2+ binding site [ion binding]; other site
103690005397	G-X-G motif; other site
103690005398	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
103690005399	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
103690005400	putative glycosyl transferase; Provisional; Region: PRK10307
103690005401	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
103690005402	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
103690005403	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
103690005404	NodB motif; other site
103690005405	active site
103690005406	catalytic site [active]
103690005407	metal binding site [ion binding]; metal-binding site
103690005408	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690005409	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690005410	non-specific DNA binding site [nucleotide binding]; other site
103690005411	salt bridge; other site
103690005412	sequence-specific DNA binding site [nucleotide binding]; other site
103690005413	proton extrusion protein PcxA; Provisional; Region: PRK02507
103690005414	methionine sulfoxide reductase A; Provisional; Region: PRK00058
103690005415	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005417	binding surface
103690005418	TPR motif; other site
103690005419	TPR repeat; Region: TPR_11; pfam13414
103690005420	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005421	binding surface
103690005422	TPR motif; other site
103690005423	TPR repeat; Region: TPR_11; pfam13414
103690005424	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005425	binding surface
103690005426	TPR motif; other site
103690005427	TPR repeat; Region: TPR_11; pfam13414
103690005428	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
103690005429	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
103690005430	Na binding site [ion binding]; other site
103690005431	Predicted membrane protein [Function unknown]; Region: COG4327
103690005432	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005434	ATP binding site [chemical binding]; other site
103690005435	Mg2+ binding site [ion binding]; other site
103690005436	G-X-G motif; other site
103690005437	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
103690005438	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
103690005439	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
103690005440	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
103690005441	MgtE intracellular N domain; Region: MgtE_N; smart00924
103690005442	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
103690005443	Divalent cation transporter; Region: MgtE; pfam01769
103690005444	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
103690005445	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690005446	catalytic residue [active]
103690005447	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690005448	Probable transposase; Region: OrfB_IS605; pfam01385
103690005449	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690005450	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690005451	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
103690005452	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
103690005453	active site
103690005454	metal binding site [ion binding]; metal-binding site
103690005455	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690005456	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690005457	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005459	dimer interface [polypeptide binding]; other site
103690005460	phosphorylation site [posttranslational modification]
103690005461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005462	ATP binding site [chemical binding]; other site
103690005463	Mg2+ binding site [ion binding]; other site
103690005464	G-X-G motif; other site
103690005465	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
103690005466	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
103690005467	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
103690005468	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005469	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690005470	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005471	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005472	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005473	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
103690005474	metal binding site 2 [ion binding]; metal-binding site
103690005475	putative DNA binding helix; other site
103690005476	metal binding site 1 [ion binding]; metal-binding site
103690005477	dimer interface [polypeptide binding]; other site
103690005478	structural Zn2+ binding site [ion binding]; other site
103690005479	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
103690005480	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690005481	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690005482	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690005483	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690005484	DNA binding residues [nucleotide binding]
103690005485	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
103690005486	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
103690005487	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
103690005488	lipoyl synthase; Provisional; Region: PRK05481
103690005489	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690005490	FeS/SAM binding site; other site
103690005491	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
103690005492	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
103690005493	acyl-activating enzyme (AAE) consensus motif; other site
103690005494	AMP binding site [chemical binding]; other site
103690005495	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690005496	Condensation domain; Region: Condensation; pfam00668
103690005497	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690005498	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690005499	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690005500	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
103690005501	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005502	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005503	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005504	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005505	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005506	Cna protein B-type domain; Region: Cna_B; pfam05738
103690005507	conserved repeat domain; Region: B_ant_repeat; TIGR01451
103690005508	conserved repeat domain; Region: B_ant_repeat; TIGR01451
103690005509	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
103690005510	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
103690005511	catalytic site [active]
103690005512	putative active site [active]
103690005513	putative substrate binding site [chemical binding]; other site
103690005514	Predicted membrane protein [Function unknown]; Region: COG2119
103690005515	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
103690005516	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
103690005517	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005518	TPR motif; other site
103690005519	binding surface
103690005520	TPR repeat; Region: TPR_11; pfam13414
103690005521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005522	binding surface
103690005523	TPR motif; other site
103690005524	Domain of unknown function DUF39; Region: DUF39; pfam01837
103690005525	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
103690005526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
103690005527	ATP binding site [chemical binding]; other site
103690005528	Mg2+ binding site [ion binding]; other site
103690005529	G-X-G motif; other site
103690005530	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690005531	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005532	active site
103690005533	phosphorylation site [posttranslational modification]
103690005534	intermolecular recognition site; other site
103690005535	dimerization interface [polypeptide binding]; other site
103690005536	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690005537	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690005538	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
103690005539	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
103690005540	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690005541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005542	active site
103690005543	phosphorylation site [posttranslational modification]
103690005544	intermolecular recognition site; other site
103690005545	dimerization interface [polypeptide binding]; other site
103690005546	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690005547	DNA binding residues [nucleotide binding]
103690005548	dimerization interface [polypeptide binding]; other site
103690005549	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
103690005550	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
103690005551	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
103690005552	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690005553	Walker A/P-loop; other site
103690005554	ATP binding site [chemical binding]; other site
103690005555	Q-loop/lid; other site
103690005556	ABC transporter signature motif; other site
103690005557	Walker B; other site
103690005558	D-loop; other site
103690005559	H-loop/switch region; other site
103690005560	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690005561	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690005562	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
103690005563	catalytic site [active]
103690005564	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
103690005565	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690005566	Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450
103690005567	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
103690005568	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
103690005569	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
103690005570	active site
103690005571	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
103690005572	CheB methylesterase; Region: CheB_methylest; pfam01339
103690005573	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
103690005574	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
103690005575	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
103690005576	PAS domain; Region: PAS_10; pfam13596
103690005577	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
103690005578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005579	dimer interface [polypeptide binding]; other site
103690005580	phosphorylation site [posttranslational modification]
103690005581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005582	ATP binding site [chemical binding]; other site
103690005583	Mg2+ binding site [ion binding]; other site
103690005584	G-X-G motif; other site
103690005585	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690005586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005587	active site
103690005588	phosphorylation site [posttranslational modification]
103690005589	intermolecular recognition site; other site
103690005590	dimerization interface [polypeptide binding]; other site
103690005591	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
103690005592	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
103690005593	nucleotide binding pocket [chemical binding]; other site
103690005594	K-X-D-G motif; other site
103690005595	catalytic site [active]
103690005596	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
103690005597	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
103690005598	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
103690005599	Dimer interface [polypeptide binding]; other site
103690005600	Stress-induced bacterial acidophilic repeat motif; Region: KGG; pfam10685
103690005601	Predicted transcriptional regulator [Transcription]; Region: COG2944
103690005602	salt bridge; other site
103690005603	non-specific DNA binding site [nucleotide binding]; other site
103690005604	sequence-specific DNA binding site [nucleotide binding]; other site
103690005605	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
103690005606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737
103690005607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690005608	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690005609	short chain dehydrogenase; Provisional; Region: PRK06197
103690005610	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
103690005611	putative NAD(P) binding site [chemical binding]; other site
103690005612	active site
103690005613	hypothetical protein; Provisional; Region: PRK06208
103690005614	intersubunit interface [polypeptide binding]; other site
103690005615	active site
103690005616	Zn2+ binding site [ion binding]; other site
103690005617	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690005618	Homeodomain-like domain; Region: HTH_23; pfam13384
103690005619	Winged helix-turn helix; Region: HTH_33; pfam13592
103690005620	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690005621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690005622	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690005623	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690005624	phosphopeptide binding site; other site
103690005625	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
103690005626	CHAT domain; Region: CHAT; cl17868
103690005627	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690005628	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690005629	phosphopeptide binding site; other site
103690005630	Double zinc ribbon; Region: DZR; pfam12773
103690005631	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
103690005632	Protein phosphatase 2C; Region: PP2C; pfam00481
103690005633	active site
103690005634	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
103690005635	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690005636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005637	active site
103690005638	phosphorylation site [posttranslational modification]
103690005639	intermolecular recognition site; other site
103690005640	dimerization interface [polypeptide binding]; other site
103690005641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690005642	DNA binding residues [nucleotide binding]
103690005643	dimerization interface [polypeptide binding]; other site
103690005644	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690005645	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690005646	active site
103690005647	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
103690005648	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
103690005649	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
103690005650	protein binding site [polypeptide binding]; other site
103690005651	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
103690005652	Catalytic dyad [active]
103690005653	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690005654	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630
103690005655	putative active site [active]
103690005656	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
103690005657	Peptidase family U32; Region: Peptidase_U32; pfam01136
103690005658	Collagenase; Region: DUF3656; pfam12392
103690005659	Peptidase family U32; Region: Peptidase_U32; cl03113
103690005660	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
103690005661	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
103690005662	nucleotide binding site [chemical binding]; other site
103690005663	NEF interaction site [polypeptide binding]; other site
103690005664	SBD interface [polypeptide binding]; other site
103690005665	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
103690005666	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
103690005667	putative NAD(P) binding site [chemical binding]; other site
103690005668	active site
103690005669	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
103690005670	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690005671	NAD binding site [chemical binding]; other site
103690005672	substrate binding site [chemical binding]; other site
103690005673	active site
103690005674	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
103690005675	C-terminal domain interface [polypeptide binding]; other site
103690005676	GSH binding site (G-site) [chemical binding]; other site
103690005677	maleylacetoacetate isomerase; Region: maiA; TIGR01262
103690005678	dimer interface [polypeptide binding]; other site
103690005679	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
103690005680	N-terminal domain interface [polypeptide binding]; other site
103690005681	dimer interface [polypeptide binding]; other site
103690005682	substrate binding pocket (H-site) [chemical binding]; other site
103690005683	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005684	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690005685	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005686	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005687	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005688	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
103690005689	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
103690005690	metal binding site [ion binding]; metal-binding site
103690005691	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
103690005692	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690005693	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690005694	structural tetrad; other site
103690005695	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
103690005696	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
103690005697	P-loop, Walker A motif; other site
103690005698	Base recognition motif; other site
103690005699	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
103690005700	Predicted membrane protein [Function unknown]; Region: COG3431
103690005701	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690005702	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
103690005703	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
103690005704	CoA-binding site [chemical binding]; other site
103690005705	ATP-binding [chemical binding]; other site
103690005706	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
103690005707	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
103690005708	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
103690005709	GAF domain; Region: GAF_3; pfam13492
103690005710	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
103690005711	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
103690005712	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
103690005713	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
103690005714	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
103690005715	P loop; other site
103690005716	GTP binding site [chemical binding]; other site
103690005717	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
103690005718	putative RNA binding site [nucleotide binding]; other site
103690005719	Uncharacterized conserved protein [Function unknown]; Region: COG2928
103690005720	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
103690005721	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690005722	putative metal binding site; other site
103690005723	putative mechanosensitive channel protein; Provisional; Region: PRK10929
103690005724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3222
103690005725	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
103690005726	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
103690005727	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690005728	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690005729	active site
103690005730	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690005731	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690005732	active site
103690005733	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
103690005734	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690005735	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690005736	active site
103690005737	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
103690005738	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
103690005739	Exonuclease VII small subunit [DNA replication, recombination, and repair]; Region: XseB; COG1722
103690005740	Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570
103690005741	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
103690005742	generic binding surface II; other site
103690005743	generic binding surface I; other site
103690005744	S-layer homology domain; Region: SLH; pfam00395
103690005745	S-layer homology domain; Region: SLH; pfam00395
103690005746	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690005747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690005748	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
103690005749	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690005750	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
103690005751	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
103690005752	Predicted metal-binding protein [Function unknown]; Region: COG5469
103690005753	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
103690005754	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
103690005755	metal ion-dependent adhesion site (MIDAS); other site
103690005756	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
103690005757	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
103690005758	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
103690005759	substrate binding site [chemical binding]; other site
103690005760	dimer interface [polypeptide binding]; other site
103690005761	ATP binding site [chemical binding]; other site
103690005762	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
103690005763	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690005764	G1 box; other site
103690005765	GTP/Mg2+ binding site [chemical binding]; other site
103690005766	G2 box; other site
103690005767	Switch I region; other site
103690005768	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690005769	G3 box; other site
103690005770	Switch II region; other site
103690005771	G4 box; other site
103690005772	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
103690005773	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
103690005774	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
103690005775	Uncharacterized conserved protein [Function unknown]; Region: COG3349
103690005776	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690005777	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
103690005778	active site
103690005779	catalytic triad [active]
103690005780	oxyanion hole [active]
103690005781	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
103690005782	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
103690005783	NodB motif; other site
103690005784	active site
103690005785	catalytic site [active]
103690005786	metal binding site [ion binding]; metal-binding site
103690005787	Predicted endonuclease distantly related to archaeal Holliday junction resolvase [DNA replication, recombination, and repair]; Region: COG0792
103690005788	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
103690005789	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
103690005790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005791	binding surface
103690005792	TPR motif; other site
103690005793	TPR repeat; Region: TPR_11; pfam13414
103690005794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005795	binding surface
103690005796	TPR motif; other site
103690005797	TPR repeat; Region: TPR_11; pfam13414
103690005798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005799	binding surface
103690005800	TPR motif; other site
103690005801	TPR repeat; Region: TPR_11; pfam13414
103690005802	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690005803	Tetratricopeptide repeat; Region: TPR_17; pfam13431
103690005804	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
103690005805	TrkA-N domain; Region: TrkA_N; pfam02254
103690005806	TrkA-C domain; Region: TrkA_C; pfam02080
103690005807	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
103690005808	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
103690005809	tocopherol O-methyltransferase; Region: PLN02244
103690005810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690005811	S-adenosylmethionine binding site [chemical binding]; other site
103690005812	PAS domain S-box; Region: sensory_box; TIGR00229
103690005813	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690005814	putative active site [active]
103690005815	heme pocket [chemical binding]; other site
103690005816	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690005817	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
103690005818	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690005819	GAF domain; Region: GAF; pfam01590
103690005820	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005822	dimer interface [polypeptide binding]; other site
103690005823	phosphorylation site [posttranslational modification]
103690005824	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005825	ATP binding site [chemical binding]; other site
103690005826	Mg2+ binding site [ion binding]; other site
103690005827	G-X-G motif; other site
103690005828	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690005829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005830	active site
103690005831	phosphorylation site [posttranslational modification]
103690005832	intermolecular recognition site; other site
103690005833	dimerization interface [polypeptide binding]; other site
103690005834	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
103690005835	substrate binding pocket [chemical binding]; other site
103690005836	substrate-Mg2+ binding site; other site
103690005837	aspartate-rich region 1; other site
103690005838	aspartate-rich region 2; other site
103690005839	Predicted membrane protein/domain [Function unknown]; Region: COG1714
103690005840	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
103690005841	Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300
103690005842	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
103690005843	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
103690005844	putative dimer interface [polypeptide binding]; other site
103690005845	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
103690005846	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
103690005847	N- and C-terminal domain interface [polypeptide binding]; other site
103690005848	active site
103690005849	MgATP binding site [chemical binding]; other site
103690005850	catalytic site [active]
103690005851	metal binding site [ion binding]; metal-binding site
103690005852	glycerol binding site [chemical binding]; other site
103690005853	homotetramer interface [polypeptide binding]; other site
103690005854	homodimer interface [polypeptide binding]; other site
103690005855	FBP binding site [chemical binding]; other site
103690005856	protein IIAGlc interface [polypeptide binding]; other site
103690005857	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690005858	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005859	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690005860	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690005861	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690005862	putative active site [active]
103690005863	S-layer homology domain; Region: SLH; pfam00395
103690005864	S-layer homology domain; Region: SLH; pfam00395
103690005865	S-layer homology domain; Region: SLH; pfam00395
103690005866	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690005867	Fasciclin domain; Region: Fasciclin; pfam02469
103690005868	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005869	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005870	binding surface
103690005871	TPR motif; other site
103690005872	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005873	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005874	TPR motif; other site
103690005875	binding surface
103690005876	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005877	TPR repeat; Region: TPR_11; pfam13414
103690005878	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690005879	binding surface
103690005880	TPR motif; other site
103690005881	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005882	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690005883	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690005884	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690005885	putative active site [active]
103690005886	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
103690005887	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
103690005888	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
103690005889	Walker A/P-loop; other site
103690005890	ATP binding site [chemical binding]; other site
103690005891	Q-loop/lid; other site
103690005892	ABC transporter signature motif; other site
103690005893	Walker B; other site
103690005894	D-loop; other site
103690005895	H-loop/switch region; other site
103690005896	TOBE domain; Region: TOBE_2; pfam08402
103690005897	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
103690005898	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
103690005899	GUN4-like; Region: GUN4; pfam05419
103690005900	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
103690005901	isocitrate dehydrogenase; Validated; Region: PRK07362
103690005902	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
103690005903	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
103690005904	phytoene desaturase; Region: phytoene_desat; TIGR02731
103690005905	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690005906	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
103690005907	active site lid residues [active]
103690005908	substrate binding pocket [chemical binding]; other site
103690005909	catalytic residues [active]
103690005910	substrate-Mg2+ binding site; other site
103690005911	aspartate-rich region 1; other site
103690005912	aspartate-rich region 2; other site
103690005913	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
103690005914	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
103690005915	putative ligand binding site [chemical binding]; other site
103690005916	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
103690005917	hypothetical protein; Provisional; Region: PRK07377
103690005918	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
103690005919	YtxH-like protein; Region: YtxH; cl02079
103690005920	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
103690005921	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690005922	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
103690005923	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
103690005924	Peptidase family M50; Region: Peptidase_M50; pfam02163
103690005925	active site
103690005926	putative substrate binding region [chemical binding]; other site
103690005927	FOG: CBS domain [General function prediction only]; Region: COG0517
103690005928	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
103690005929	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
103690005930	Response regulator receiver domain; Region: Response_reg; pfam00072
103690005931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005932	active site
103690005933	phosphorylation site [posttranslational modification]
103690005934	intermolecular recognition site; other site
103690005935	dimerization interface [polypeptide binding]; other site
103690005936	PAS domain S-box; Region: sensory_box; TIGR00229
103690005937	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690005938	putative active site [active]
103690005939	heme pocket [chemical binding]; other site
103690005940	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690005941	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690005942	dimer interface [polypeptide binding]; other site
103690005943	phosphorylation site [posttranslational modification]
103690005944	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690005945	ATP binding site [chemical binding]; other site
103690005946	Mg2+ binding site [ion binding]; other site
103690005947	G-X-G motif; other site
103690005948	Response regulator receiver domain; Region: Response_reg; pfam00072
103690005949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690005950	active site
103690005951	phosphorylation site [posttranslational modification]
103690005952	intermolecular recognition site; other site
103690005953	dimerization interface [polypeptide binding]; other site
103690005954	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
103690005955	CheB methylesterase; Region: CheB_methylest; pfam01339
103690005956	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
103690005957	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
103690005958	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
103690005959	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
103690005960	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
103690005961	TPP-binding site [chemical binding]; other site
103690005962	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
103690005963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690005964	Homeodomain-like domain; Region: HTH_23; pfam13384
103690005965	Winged helix-turn helix; Region: HTH_33; pfam13592
103690005966	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690005967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690005968	Predicted ATPase [General function prediction only]; Region: COG5293
103690005969	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
103690005970	Homeodomain-like domain; Region: HTH_23; cl17451
103690005971	Winged helix-turn helix; Region: HTH_29; pfam13551
103690005972	Homeodomain-like domain; Region: HTH_32; pfam13565
103690005973	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690005974	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690005975	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
103690005976	Bacterial SH3 domain; Region: SH3_3; pfam08239
103690005977	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690005978	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005979	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690005980	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690005981	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690005982	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
103690005983	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
103690005984	tetramer interface [polypeptide binding]; other site
103690005985	active site
103690005986	Mg2+/Mn2+ binding site [ion binding]; other site
103690005987	NADPH_oxidase. Nitroreductase family containing NADH oxidase and other, uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles; Region: NADH_oxidase; cd03370
103690005988	dimer interface [polypeptide binding]; other site
103690005989	FMN binding site [chemical binding]; other site
103690005990	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
103690005991	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
103690005992	FMN binding site [chemical binding]; other site
103690005993	active site
103690005994	substrate binding site [chemical binding]; other site
103690005995	catalytic residue [active]
103690005996	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690005997	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690005998	catalytic residues [active]
103690005999	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690006000	dimerization interface [polypeptide binding]; other site
103690006001	putative DNA binding site [nucleotide binding]; other site
103690006002	putative Zn2+ binding site [ion binding]; other site
103690006003	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690006004	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
103690006005	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690006006	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690006007	active site
103690006008	ATP binding site [chemical binding]; other site
103690006009	substrate binding site [chemical binding]; other site
103690006010	activation loop (A-loop); other site
103690006011	Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346
103690006012	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690006013	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
103690006014	Ycf46; Provisional; Region: ycf46; CHL00195
103690006015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690006016	Walker A motif; other site
103690006017	ATP binding site [chemical binding]; other site
103690006018	Walker B motif; other site
103690006019	arginine finger; other site
103690006020	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690006021	active site
103690006022	metal binding site [ion binding]; metal-binding site
103690006023	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690006024	putative lipid kinase; Reviewed; Region: PRK00861
103690006025	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
103690006026	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755
103690006027	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
103690006028	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
103690006029	domain interfaces; other site
103690006030	active site
103690006031	glycogen synthase; Provisional; Region: glgA; PRK00654
103690006032	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
103690006033	ADP-binding pocket [chemical binding]; other site
103690006034	homodimer interface [polypeptide binding]; other site
103690006035	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
103690006036	diiron binding motif [ion binding]; other site
103690006037	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
103690006038	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
103690006039	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
103690006040	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
103690006041	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
103690006042	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
103690006043	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690006044	dimerization interface [polypeptide binding]; other site
103690006045	GAF domain; Region: GAF; pfam01590
103690006046	GAF domain; Region: GAF_2; pfam13185
103690006047	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
103690006048	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006049	ATP binding site [chemical binding]; other site
103690006050	Mg2+ binding site [ion binding]; other site
103690006051	G-X-G motif; other site
103690006052	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006053	active site
103690006054	phosphorylation site [posttranslational modification]
103690006055	intermolecular recognition site; other site
103690006056	dimerization interface [polypeptide binding]; other site
103690006057	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690006058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006059	active site
103690006060	phosphorylation site [posttranslational modification]
103690006061	intermolecular recognition site; other site
103690006062	dimerization interface [polypeptide binding]; other site
103690006063	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006065	active site
103690006066	phosphorylation site [posttranslational modification]
103690006067	intermolecular recognition site; other site
103690006068	dimerization interface [polypeptide binding]; other site
103690006069	short chain dehydrogenase; Provisional; Region: PRK08219
103690006070	classical (c) SDRs; Region: SDR_c; cd05233
103690006071	NAD(P) binding site [chemical binding]; other site
103690006072	active site
103690006073	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
103690006074	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
103690006075	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690006076	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690006077	active site
103690006078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
103690006079	NACHT domain; Region: NACHT; pfam05729
103690006080	HEAT repeats; Region: HEAT_2; pfam13646
103690006081	HEAT repeats; Region: HEAT_2; pfam13646
103690006082	HEAT repeats; Region: HEAT_2; pfam13646
103690006083	HEAT repeats; Region: HEAT_2; pfam13646
103690006084	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690006085	putative active site [active]
103690006086	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
103690006087	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
103690006088	ligand binding site [chemical binding]; other site
103690006089	NAD binding site [chemical binding]; other site
103690006090	dimerization interface [polypeptide binding]; other site
103690006091	catalytic site [active]
103690006092	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
103690006093	putative L-serine binding site [chemical binding]; other site
103690006094	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
103690006095	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006096	S-adenosylmethionine binding site [chemical binding]; other site
103690006097	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690006098	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690006099	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690006100	catalytic residues [active]
103690006101	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
103690006102	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
103690006103	NAD(P) binding site [chemical binding]; other site
103690006104	homotetramer interface [polypeptide binding]; other site
103690006105	homodimer interface [polypeptide binding]; other site
103690006106	active site
103690006107	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
103690006108	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
103690006109	Mg++ binding site [ion binding]; other site
103690006110	putative catalytic motif [active]
103690006111	substrate binding site [chemical binding]; other site
103690006112	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
103690006113	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
103690006114	ring oligomerisation interface [polypeptide binding]; other site
103690006115	ATP/Mg binding site [chemical binding]; other site
103690006116	stacking interactions; other site
103690006117	hinge regions; other site
103690006118	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
103690006119	heme binding pocket [chemical binding]; other site
103690006120	heme ligand [chemical binding]; other site
103690006121	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
103690006122	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
103690006123	active site
103690006124	substrate binding site [chemical binding]; other site
103690006125	metal binding site [ion binding]; metal-binding site
103690006126	RNA 3'-phosphate cyclase; Region: RNA_3prim_cycl; TIGR03399
103690006127	RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874
103690006128	putative active site [active]
103690006129	adenylation catalytic residue [active]
103690006130	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690006131	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006132	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690006133	protein binding surface [polypeptide binding]; other site
103690006134	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006135	protein binding surface [polypeptide binding]; other site
103690006136	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690006137	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690006138	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006139	protein binding surface [polypeptide binding]; other site
103690006140	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006141	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690006142	protein binding surface [polypeptide binding]; other site
103690006143	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006144	protein binding surface [polypeptide binding]; other site
103690006145	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006146	protein binding surface [polypeptide binding]; other site
103690006147	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006148	protein binding surface [polypeptide binding]; other site
103690006149	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690006150	protein binding surface [polypeptide binding]; other site
103690006151	HEAT-like repeat; Region: HEAT_EZ; pfam13513
103690006152	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
103690006153	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
103690006154	putative active site [active]
103690006155	putative metal binding site [ion binding]; other site
103690006156	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690006157	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690006158	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690006159	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690006160	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690006161	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006162	PAS domain; Region: PAS_9; pfam13426
103690006163	putative active site [active]
103690006164	heme pocket [chemical binding]; other site
103690006165	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
103690006166	cyclase homology domain; Region: CHD; cd07302
103690006167	nucleotidyl binding site; other site
103690006168	metal binding site [ion binding]; metal-binding site
103690006169	dimer interface [polypeptide binding]; other site
103690006170	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690006171	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690006172	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690006173	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
103690006174	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
103690006175	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690006176	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
103690006177	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
103690006178	dimer interface [polypeptide binding]; other site
103690006179	PYR/PP interface [polypeptide binding]; other site
103690006180	TPP binding site [chemical binding]; other site
103690006181	substrate binding site [chemical binding]; other site
103690006182	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
103690006183	Domain of unknown function; Region: EKR; smart00890
103690006184	4Fe-4S binding domain; Region: Fer4_6; pfam12837
103690006185	4Fe-4S binding domain; Region: Fer4; pfam00037
103690006186	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
103690006187	TPP-binding site [chemical binding]; other site
103690006188	dimer interface [polypeptide binding]; other site
103690006189	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
103690006190	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
103690006191	putative active site [active]
103690006192	putative FMN binding site [chemical binding]; other site
103690006193	putative substrate binding site [chemical binding]; other site
103690006194	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
103690006195	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
103690006196	active site
103690006197	ADP/pyrophosphate binding site [chemical binding]; other site
103690006198	dimerization interface [polypeptide binding]; other site
103690006199	allosteric effector site; other site
103690006200	fructose-1,6-bisphosphate binding site; other site
103690006201	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
103690006202	FOG: CBS domain [General function prediction only]; Region: COG0517
103690006203	PAS domain S-box; Region: sensory_box; TIGR00229
103690006204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006205	putative active site [active]
103690006206	heme pocket [chemical binding]; other site
103690006207	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006208	PAS fold; Region: PAS_3; pfam08447
103690006209	putative active site [active]
103690006210	heme pocket [chemical binding]; other site
103690006211	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006212	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690006213	putative active site [active]
103690006214	heme pocket [chemical binding]; other site
103690006215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006216	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690006217	putative active site [active]
103690006218	heme pocket [chemical binding]; other site
103690006219	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690006220	dimer interface [polypeptide binding]; other site
103690006221	phosphorylation site [posttranslational modification]
103690006222	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006223	ATP binding site [chemical binding]; other site
103690006224	Mg2+ binding site [ion binding]; other site
103690006225	G-X-G motif; other site
103690006226	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006228	active site
103690006229	phosphorylation site [posttranslational modification]
103690006230	intermolecular recognition site; other site
103690006231	dimerization interface [polypeptide binding]; other site
103690006232	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
103690006233	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
103690006234	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690006235	active site
103690006236	ATP binding site [chemical binding]; other site
103690006237	substrate binding site [chemical binding]; other site
103690006238	activation loop (A-loop); other site
103690006239	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690006240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006241	S-adenosylmethionine binding site [chemical binding]; other site
103690006242	Biotin synthase and related enzymes [Coenzyme metabolism]; Region: BioB; COG0502
103690006243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690006244	FeS/SAM binding site; other site
103690006245	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
103690006246	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690006247	putative active site [active]
103690006248	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
103690006249	active site
103690006250	dimer interface [polypeptide binding]; other site
103690006251	metal binding site [ion binding]; metal-binding site
103690006252	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690006253	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
103690006254	Homeodomain-like domain; Region: HTH_23; pfam13384
103690006255	Winged helix-turn helix; Region: HTH_29; pfam13551
103690006256	Winged helix-turn helix; Region: HTH_33; pfam13592
103690006257	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
103690006258	ligand binding site [chemical binding]; other site
103690006259	flexible hinge region; other site
103690006260	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690006261	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
103690006262	putative active site [active]
103690006263	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690006264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690006265	Walker A/P-loop; other site
103690006266	ATP binding site [chemical binding]; other site
103690006267	Q-loop/lid; other site
103690006268	ABC transporter signature motif; other site
103690006269	Walker B; other site
103690006270	D-loop; other site
103690006271	H-loop/switch region; other site
103690006272	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690006273	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
103690006274	E3 interaction surface; other site
103690006275	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690006276	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690006277	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
103690006278	replication factor C subunit; Provisional; Region: PLN03025
103690006279	Phosphotransferase enzyme family; Region: APH; pfam01636
103690006280	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
103690006281	substrate binding site [chemical binding]; other site
103690006282	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690006283	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690006284	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690006285	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690006286	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690006287	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690006288	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690006289	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690006290	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
103690006291	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
103690006292	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
103690006293	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
103690006294	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
103690006295	active site
103690006296	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
103690006297	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
103690006298	Walker A/P-loop; other site
103690006299	ATP binding site [chemical binding]; other site
103690006300	Q-loop/lid; other site
103690006301	ABC transporter signature motif; other site
103690006302	Walker B; other site
103690006303	D-loop; other site
103690006304	H-loop/switch region; other site
103690006305	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
103690006306	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
103690006307	Walker A/P-loop; other site
103690006308	ATP binding site [chemical binding]; other site
103690006309	Q-loop/lid; other site
103690006310	ABC transporter signature motif; other site
103690006311	Walker B; other site
103690006312	D-loop; other site
103690006313	H-loop/switch region; other site
103690006314	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
103690006315	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
103690006316	TM-ABC transporter signature motif; other site
103690006317	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
103690006318	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
103690006319	TM-ABC transporter signature motif; other site
103690006320	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
103690006321	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
103690006322	putative ligand binding site [chemical binding]; other site
103690006323	signal recognition particle protein; Provisional; Region: PRK10867
103690006324	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
103690006325	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
103690006326	GTP binding site [chemical binding]; other site
103690006327	Signal peptide binding domain; Region: SRP_SPB; pfam02978
103690006328	ribosomal protein S16; Region: rps16; CHL00005
103690006329	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
103690006330	KH domain; Region: KH_4; pfam13083
103690006331	G-X-X-G motif; other site
103690006332	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
103690006333	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
103690006334	PhoH-like protein; Region: PhoH; pfam02562
103690006335	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
103690006336	TIR domain; Region: TIR_2; pfam13676
103690006337	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
103690006338	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
103690006339	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
103690006340	Clp protease ATP binding subunit; Region: clpC; CHL00095
103690006341	Clp amino terminal domain; Region: Clp_N; pfam02861
103690006342	Clp amino terminal domain; Region: Clp_N; pfam02861
103690006343	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690006344	Walker A motif; other site
103690006345	ATP binding site [chemical binding]; other site
103690006346	Walker B motif; other site
103690006347	arginine finger; other site
103690006348	UvrB/uvrC motif; Region: UVR; pfam02151
103690006349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690006350	Walker A motif; other site
103690006351	ATP binding site [chemical binding]; other site
103690006352	Walker B motif; other site
103690006353	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
103690006354	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690006355	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006356	active site
103690006357	phosphorylation site [posttranslational modification]
103690006358	intermolecular recognition site; other site
103690006359	dimerization interface [polypeptide binding]; other site
103690006360	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690006361	DNA binding site [nucleotide binding]
103690006362	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
103690006363	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
103690006364	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690006365	GAF domain; Region: GAF; pfam01590
103690006366	PAS fold; Region: PAS_4; pfam08448
103690006367	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006368	putative active site [active]
103690006369	heme pocket [chemical binding]; other site
103690006370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006371	PAS fold; Region: PAS_3; pfam08447
103690006372	putative active site [active]
103690006373	heme pocket [chemical binding]; other site
103690006374	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690006375	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690006376	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690006377	dimer interface [polypeptide binding]; other site
103690006378	phosphorylation site [posttranslational modification]
103690006379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006380	ATP binding site [chemical binding]; other site
103690006381	Mg2+ binding site [ion binding]; other site
103690006382	G-X-G motif; other site
103690006383	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006384	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006385	active site
103690006386	phosphorylation site [posttranslational modification]
103690006387	intermolecular recognition site; other site
103690006388	dimerization interface [polypeptide binding]; other site
103690006389	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690006390	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006391	active site
103690006392	phosphorylation site [posttranslational modification]
103690006393	intermolecular recognition site; other site
103690006394	dimerization interface [polypeptide binding]; other site
103690006395	PAS fold; Region: PAS_4; pfam08448
103690006396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006397	putative active site [active]
103690006398	heme pocket [chemical binding]; other site
103690006399	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690006400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006401	putative active site [active]
103690006402	heme pocket [chemical binding]; other site
103690006403	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690006404	dimer interface [polypeptide binding]; other site
103690006405	phosphorylation site [posttranslational modification]
103690006406	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006407	ATP binding site [chemical binding]; other site
103690006408	Mg2+ binding site [ion binding]; other site
103690006409	G-X-G motif; other site
103690006410	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006411	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006412	active site
103690006413	phosphorylation site [posttranslational modification]
103690006414	intermolecular recognition site; other site
103690006415	dimerization interface [polypeptide binding]; other site
103690006416	Domain of unknown function (DUF3893); Region: DUF3893; pfam13032
103690006417	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690006418	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690006419	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690006420	Homeodomain-like domain; Region: HTH_23; pfam13384
103690006421	Winged helix-turn helix; Region: HTH_33; pfam13592
103690006422	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690006423	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690006424	non-specific DNA binding site [nucleotide binding]; other site
103690006425	salt bridge; other site
103690006426	sequence-specific DNA binding site [nucleotide binding]; other site
103690006427	Domain of unknown function (DUF955); Region: DUF955; pfam06114
103690006428	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690006429	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690006430	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
103690006431	Walker A/P-loop; other site
103690006432	ATP binding site [chemical binding]; other site
103690006433	Q-loop/lid; other site
103690006434	ABC transporter signature motif; other site
103690006435	Walker B; other site
103690006436	D-loop; other site
103690006437	H-loop/switch region; other site
103690006438	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
103690006439	active site
103690006440	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690006441	putative dimer interface [polypeptide binding]; other site
103690006442	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690006443	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
103690006444	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
103690006445	nucleotide binding site [chemical binding]; other site
103690006446	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
103690006447	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
103690006448	Competence protein; Region: Competence; pfam03772
103690006449	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
103690006450	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690006451	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
103690006452	dimer interface [polypeptide binding]; other site
103690006453	motif 1; other site
103690006454	active site
103690006455	motif 2; other site
103690006456	motif 3; other site
103690006457	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690006458	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690006459	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690006460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006461	S-adenosylmethionine binding site [chemical binding]; other site
103690006462	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
103690006463	DHH family; Region: DHH; pfam01368
103690006464	DHHA1 domain; Region: DHHA1; pfam02272
103690006465	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690006466	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690006467	Coenzyme A binding pocket [chemical binding]; other site
103690006468	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
103690006469	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690006470	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690006471	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690006472	active site
103690006473	Uncharacterized conserved protein [Function unknown]; Region: COG5502
103690006474	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB [Energy production and conversion]; Region: NqrB; COG1805
103690006475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
103690006476	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
103690006477	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
103690006478	nitrilase; Region: PLN02798
103690006479	putative active site [active]
103690006480	catalytic triad [active]
103690006481	dimer interface [polypeptide binding]; other site
103690006482	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
103690006483	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690006484	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690006485	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
103690006486	active site
103690006487	catalytic residues [active]
103690006488	metal binding site [ion binding]; metal-binding site
103690006489	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
103690006490	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
103690006491	protein binding site [polypeptide binding]; other site
103690006492	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
103690006493	DnaA N-terminal domain; Region: DnaA_N; pfam11638
103690006494	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690006495	Walker A motif; other site
103690006496	ATP binding site [chemical binding]; other site
103690006497	Walker B motif; other site
103690006498	arginine finger; other site
103690006499	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
103690006500	DnaA box-binding interface [nucleotide binding]; other site
103690006501	DNA polymerase III subunit beta; Validated; Region: PRK05643
103690006502	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
103690006503	putative DNA binding surface [nucleotide binding]; other site
103690006504	dimer interface [polypeptide binding]; other site
103690006505	beta-clamp/clamp loader binding surface; other site
103690006506	beta-clamp/translesion DNA polymerase binding surface; other site
103690006507	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
103690006508	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
103690006509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690006510	dimer interface [polypeptide binding]; other site
103690006511	conserved gate region; other site
103690006512	putative PBP binding loops; other site
103690006513	ABC-ATPase subunit interface; other site
103690006514	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
103690006515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690006516	putative PBP binding loops; other site
103690006517	dimer interface [polypeptide binding]; other site
103690006518	ABC-ATPase subunit interface; other site
103690006519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006520	S-adenosylmethionine binding site [chemical binding]; other site
103690006521	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
103690006522	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
103690006523	nudix motif; other site
103690006524	Predicted transcriptional regulators [Transcription]; Region: COG1695
103690006525	Transcriptional regulator PadR-like family; Region: PadR; cl17335
103690006526	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
103690006527	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
103690006528	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690006529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690006530	Walker A/P-loop; other site
103690006531	ATP binding site [chemical binding]; other site
103690006532	Q-loop/lid; other site
103690006533	ABC transporter signature motif; other site
103690006534	Walker B; other site
103690006535	D-loop; other site
103690006536	H-loop/switch region; other site
103690006537	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
103690006538	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
103690006539	putative active site [active]
103690006540	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690006541	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690006542	Walker A/P-loop; other site
103690006543	ATP binding site [chemical binding]; other site
103690006544	Q-loop/lid; other site
103690006545	ABC transporter signature motif; other site
103690006546	Walker B; other site
103690006547	D-loop; other site
103690006548	H-loop/switch region; other site
103690006549	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
103690006550	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690006551	Domain of unknown function (DUF4315); Region: DUF4315; pfam14193
103690006552	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690006553	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
103690006554	B12 binding domain; Region: B12-binding; pfam02310
103690006555	B12 binding site [chemical binding]; other site
103690006556	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
103690006557	Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403
103690006558	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
103690006559	active site
103690006560	zinc binding site [ion binding]; other site
103690006561	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
103690006562	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
103690006563	nif11-class peptide radical SAM maturase 3; Region: rSAM_nif11_3; TIGR04103
103690006564	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690006565	FeS/SAM binding site; other site
103690006566	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
103690006567	nif11-like leader peptide domain; Region: ocin_TIGR03798
103690006568	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690006569	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
103690006570	ligand binding site [chemical binding]; other site
103690006571	flexible hinge region; other site
103690006572	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690006573	ligand binding site [chemical binding]; other site
103690006574	flexible hinge region; other site
103690006575	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
103690006576	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690006577	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690006578	Cache domain; Region: Cache_1; pfam02743
103690006579	HAMP domain; Region: HAMP; pfam00672
103690006580	dimerization interface [polypeptide binding]; other site
103690006581	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006582	PAS domain; Region: PAS_9; pfam13426
103690006583	putative active site [active]
103690006584	heme pocket [chemical binding]; other site
103690006585	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690006586	Helix-turn-helix domain; Region: HTH_18; pfam12833
103690006587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690006588	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690006589	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690006590	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
103690006591	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
103690006592	putative heme binding site [chemical binding]; other site
103690006593	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
103690006594	Phosphotransferase enzyme family; Region: APH; pfam01636
103690006595	active site
103690006596	substrate binding site [chemical binding]; other site
103690006597	ATP binding site [chemical binding]; other site
103690006598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690006599	non-specific DNA binding site [nucleotide binding]; other site
103690006600	salt bridge; other site
103690006601	sequence-specific DNA binding site [nucleotide binding]; other site
103690006602	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
103690006603	metal ion-dependent adhesion site (MIDAS); other site
103690006604	Tubulin like; Region: Tubulin_2; pfam13809
103690006605	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
103690006606	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
103690006607	putative cation:proton antiport protein; Provisional; Region: PRK10669
103690006608	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690006609	TrkA-N domain; Region: TrkA_N; pfam02254
103690006610	TrkA-C domain; Region: TrkA_C; pfam02080
103690006611	TrkA-C domain; Region: TrkA_C; pfam02080
103690006612	bacterial Hfq-like; Region: Hfq; cd01716
103690006613	hexamer interface [polypeptide binding]; other site
103690006614	Sm1 motif; other site
103690006615	RNA binding site [nucleotide binding]; other site
103690006616	Sm2 motif; other site
103690006617	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
103690006618	diaminopimelate epimerase; Region: PLN02536
103690006619	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
103690006620	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690006621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006622	active site
103690006623	phosphorylation site [posttranslational modification]
103690006624	intermolecular recognition site; other site
103690006625	dimerization interface [polypeptide binding]; other site
103690006626	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
103690006627	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
103690006628	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690006629	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
103690006630	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
103690006631	Domain of unknown function (DUF1338); Region: DUF1338; cl02226
103690006632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4293
103690006633	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690006634	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
103690006635	active site
103690006636	catalytic tetrad [active]
103690006637	hydrolase, alpha/beta fold family protein; Region: PLN02824
103690006638	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690006639	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
103690006640	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
103690006641	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
103690006642	shikimate binding site; other site
103690006643	NAD(P) binding site [chemical binding]; other site
103690006644	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690006645	YGGT family; Region: YGGT; pfam02325
103690006646	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690006647	active site
103690006648	carotene isomerase; Region: carot_isom; TIGR02730
103690006649	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690006650	hydroxyglutarate oxidase; Provisional; Region: PRK11728
103690006651	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690006652	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690006653	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690006654	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690006655	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690006656	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690006657	Homeodomain-like domain; Region: HTH_23; pfam13384
103690006658	Winged helix-turn helix; Region: HTH_33; pfam13592
103690006659	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690006660	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
103690006661	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
103690006662	threonine synthase; Reviewed; Region: PRK06721
103690006663	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
103690006664	homodimer interface [polypeptide binding]; other site
103690006665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690006666	catalytic residue [active]
103690006667	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
103690006668	heterotetramer interface [polypeptide binding]; other site
103690006669	active site pocket [active]
103690006670	cleavage site
103690006671	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
103690006672	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690006673	dimer interface [polypeptide binding]; other site
103690006674	putative metal binding site [ion binding]; other site
103690006675	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
103690006676	Resolvase, N terminal domain; Region: Resolvase; smart00857
103690006677	catalytic residues [active]
103690006678	Recombinase; Region: Recombinase; pfam07508
103690006679	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
103690006680	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
103690006681	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
103690006682	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
103690006683	Cl- selectivity filter; other site
103690006684	Cl- binding residues [ion binding]; other site
103690006685	pore gating glutamate residue; other site
103690006686	dimer interface [polypeptide binding]; other site
103690006687	FOG: CBS domain [General function prediction only]; Region: COG0517
103690006688	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
103690006689	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
103690006690	Predicted transcriptional regulator [Transcription]; Region: COG1959
103690006691	Transcriptional regulator; Region: Rrf2; cl17282
103690006692	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
103690006693	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
103690006694	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690006695	active site
103690006696	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
103690006697	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006698	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690006699	S-adenosylmethionine binding site [chemical binding]; other site
103690006700	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
103690006701	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690006702	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690006703	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
103690006704	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
103690006705	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
103690006706	S-layer homology domain; Region: SLH; pfam00395
103690006707	S-layer homology domain; Region: SLH; pfam00395
103690006708	S-layer homology domain; Region: SLH; pfam00395
103690006709	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
103690006710	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
103690006711	dimerization interface [polypeptide binding]; other site
103690006712	active site
103690006713	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
103690006714	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690006715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690006716	homodimer interface [polypeptide binding]; other site
103690006717	catalytic residue [active]
103690006718	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690006719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006720	active site
103690006721	phosphorylation site [posttranslational modification]
103690006722	intermolecular recognition site; other site
103690006723	dimerization interface [polypeptide binding]; other site
103690006724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006725	putative active site [active]
103690006726	heme pocket [chemical binding]; other site
103690006727	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690006728	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690006729	dimer interface [polypeptide binding]; other site
103690006730	phosphorylation site [posttranslational modification]
103690006731	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006732	ATP binding site [chemical binding]; other site
103690006733	Mg2+ binding site [ion binding]; other site
103690006734	G-X-G motif; other site
103690006735	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
103690006736	FOG: CBS domain [General function prediction only]; Region: COG0517
103690006737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006738	putative active site [active]
103690006739	PAS fold; Region: PAS_3; pfam08447
103690006740	heme pocket [chemical binding]; other site
103690006741	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006742	PAS fold; Region: PAS_3; pfam08447
103690006743	putative active site [active]
103690006744	heme pocket [chemical binding]; other site
103690006745	PAS domain S-box; Region: sensory_box; TIGR00229
103690006746	PAS domain; Region: PAS; smart00091
103690006747	putative active site [active]
103690006748	heme pocket [chemical binding]; other site
103690006749	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006750	PAS fold; Region: PAS_3; pfam08447
103690006751	putative active site [active]
103690006752	heme pocket [chemical binding]; other site
103690006753	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006754	PAS domain; Region: PAS_9; pfam13426
103690006755	putative active site [active]
103690006756	heme pocket [chemical binding]; other site
103690006757	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690006758	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006759	putative active site [active]
103690006760	heme pocket [chemical binding]; other site
103690006761	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006762	PAS fold; Region: PAS_3; pfam08447
103690006763	putative active site [active]
103690006764	heme pocket [chemical binding]; other site
103690006765	PAS fold; Region: PAS_4; pfam08448
103690006766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006767	putative active site [active]
103690006768	heme pocket [chemical binding]; other site
103690006769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006770	PAS domain; Region: PAS_9; pfam13426
103690006771	putative active site [active]
103690006772	heme pocket [chemical binding]; other site
103690006773	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
103690006774	Histidine kinase; Region: HisKA_2; pfam07568
103690006775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006776	ATP binding site [chemical binding]; other site
103690006777	Mg2+ binding site [ion binding]; other site
103690006778	G-X-G motif; other site
103690006779	Alternative oxidase, ferritin-like diiron-binding domain; Region: AOX; cd01053
103690006780	diiron binding motif [ion binding]; other site
103690006781	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
103690006782	Pheophorbide a oxygenase; Region: PaO; pfam08417
103690006783	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
103690006784	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
103690006785	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
103690006786	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
103690006787	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
103690006788	metal binding site [ion binding]; metal-binding site
103690006789	dimer interface [polypeptide binding]; other site
103690006790	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690006791	putative active site [active]
103690006792	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
103690006793	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
103690006794	B12 binding site [chemical binding]; other site
103690006795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690006796	FeS/SAM binding site; other site
103690006797	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
103690006798	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
103690006799	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
103690006800	Predicted transcriptional regulators [Transcription]; Region: COG1733
103690006801	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690006802	dimerization interface [polypeptide binding]; other site
103690006803	putative DNA binding site [nucleotide binding]; other site
103690006804	putative Zn2+ binding site [ion binding]; other site
103690006805	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
103690006806	metal ion-dependent adhesion site (MIDAS); other site
103690006807	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
103690006808	metal ion-dependent adhesion site (MIDAS); other site
103690006809	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
103690006810	metal ion-dependent adhesion site (MIDAS); other site
103690006811	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
103690006812	TrkA-N domain; Region: TrkA_N; pfam02254
103690006813	TrkA-C domain; Region: TrkA_C; pfam02080
103690006814	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
103690006815	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
103690006816	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
103690006817	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
103690006818	Peptidase family M50; Region: Peptidase_M50; pfam02163
103690006819	active site
103690006820	putative substrate binding region [chemical binding]; other site
103690006821	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690006822	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690006823	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690006824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690006825	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690006826	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
103690006827	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
103690006828	G1 box; other site
103690006829	GTP/Mg2+ binding site [chemical binding]; other site
103690006830	Switch I region; other site
103690006831	G2 box; other site
103690006832	G3 box; other site
103690006833	Switch II region; other site
103690006834	G4 box; other site
103690006835	G5 box; other site
103690006836	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
103690006837	Nucleoside recognition; Region: Gate; pfam07670
103690006838	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
103690006839	Nucleoside recognition; Region: Gate; pfam07670
103690006840	FeoA domain; Region: FeoA; pfam04023
103690006841	tocopherol O-methyltransferase; Region: PLN02244
103690006842	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690006843	S-adenosylmethionine binding site [chemical binding]; other site
103690006844	Isochorismatase family; Region: Isochorismatase; pfam00857
103690006845	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
103690006846	catalytic triad [active]
103690006847	conserved cis-peptide bond; other site
103690006848	PAS domain S-box; Region: sensory_box; TIGR00229
103690006849	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006850	putative active site [active]
103690006851	heme pocket [chemical binding]; other site
103690006852	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690006853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690006854	dimer interface [polypeptide binding]; other site
103690006855	phosphorylation site [posttranslational modification]
103690006856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006857	ATP binding site [chemical binding]; other site
103690006858	Mg2+ binding site [ion binding]; other site
103690006859	G-X-G motif; other site
103690006860	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690006861	Caspase domain; Region: Peptidase_C14; pfam00656
103690006862	AAA ATPase domain; Region: AAA_16; pfam13191
103690006863	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690006864	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690006865	structural tetrad; other site
103690006866	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690006867	structural tetrad; other site
103690006868	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690006869	WD40 repeats; Region: WD40; smart00320
103690006870	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
103690006871	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690006872	FeS/SAM binding site; other site
103690006873	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
103690006874	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690006875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690006876	Walker A motif; other site
103690006877	ATP binding site [chemical binding]; other site
103690006878	Walker B motif; other site
103690006879	HEAT repeats; Region: HEAT_2; pfam13646
103690006880	Predicted permease [General function prediction only]; Region: COG3329
103690006881	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690006882	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690006883	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690006884	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690006885	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690006886	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690006887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006888	putative active site [active]
103690006889	heme pocket [chemical binding]; other site
103690006890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006891	putative active site [active]
103690006892	heme pocket [chemical binding]; other site
103690006893	PAS fold; Region: PAS_4; pfam08448
103690006894	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690006895	putative active site [active]
103690006896	heme pocket [chemical binding]; other site
103690006897	Histidine kinase; Region: HisKA_3; pfam07730
103690006898	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
103690006899	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006900	ATP binding site [chemical binding]; other site
103690006901	Mg2+ binding site [ion binding]; other site
103690006902	G-X-G motif; other site
103690006903	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690006904	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006905	active site
103690006906	phosphorylation site [posttranslational modification]
103690006907	intermolecular recognition site; other site
103690006908	dimerization interface [polypeptide binding]; other site
103690006909	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690006910	dimerization interface [polypeptide binding]; other site
103690006911	DNA binding residues [nucleotide binding]
103690006912	AIR carboxylase; Region: AIRC; cl00310
103690006913	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
103690006914	Thioredoxin; Region: Thioredoxin_4; cl17273
103690006915	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
103690006916	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
103690006917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690006918	NAD(P) binding site [chemical binding]; other site
103690006919	active site
103690006920	CAAX protease self-immunity; Region: Abi; pfam02517
103690006921	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
103690006922	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690006923	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690006924	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690006925	Walker A/P-loop; other site
103690006926	ATP binding site [chemical binding]; other site
103690006927	Q-loop/lid; other site
103690006928	ABC transporter signature motif; other site
103690006929	Walker B; other site
103690006930	D-loop; other site
103690006931	H-loop/switch region; other site
103690006932	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690006933	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690006934	siderophore binding site; other site
103690006935	AMIN domain; Region: AMIN; pfam11741
103690006936	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690006937	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690006938	N-terminal plug; other site
103690006939	ligand-binding site [chemical binding]; other site
103690006940	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690006941	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690006942	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690006943	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
103690006944	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690006945	N-terminal plug; other site
103690006946	ligand-binding site [chemical binding]; other site
103690006947	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
103690006948	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
103690006949	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690006950	Predicted metal-binding protein [Function unknown]; Region: COG5469
103690006951	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690006952	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690006953	siderophore binding site; other site
103690006954	AMIN domain; Region: AMIN; pfam11741
103690006955	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690006956	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690006957	N-terminal plug; other site
103690006958	ligand-binding site [chemical binding]; other site
103690006959	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690006960	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690006961	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
103690006962	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690006963	putative binding surface; other site
103690006964	active site
103690006965	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
103690006966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690006967	ATP binding site [chemical binding]; other site
103690006968	Mg2+ binding site [ion binding]; other site
103690006969	G-X-G motif; other site
103690006970	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
103690006971	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690006972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006973	active site
103690006974	phosphorylation site [posttranslational modification]
103690006975	intermolecular recognition site; other site
103690006976	dimerization interface [polypeptide binding]; other site
103690006977	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690006978	dimerization interface [polypeptide binding]; other site
103690006979	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
103690006980	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
103690006981	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
103690006982	dimer interface [polypeptide binding]; other site
103690006983	putative CheW interface [polypeptide binding]; other site
103690006984	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
103690006985	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006986	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006987	active site
103690006988	phosphorylation site [posttranslational modification]
103690006989	intermolecular recognition site; other site
103690006990	dimerization interface [polypeptide binding]; other site
103690006991	Response regulator receiver domain; Region: Response_reg; pfam00072
103690006992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690006993	active site
103690006994	phosphorylation site [posttranslational modification]
103690006995	intermolecular recognition site; other site
103690006996	dimerization interface [polypeptide binding]; other site
103690006997	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
103690006998	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
103690006999	putative catalytic cysteine [active]
103690007000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
103690007001	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690007002	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690007003	Probable transposase; Region: OrfB_IS605; pfam01385
103690007004	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690007005	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690007006	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690007007	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690007008	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690007009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690007010	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690007011	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690007012	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690007013	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690007014	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
103690007015	Protein of unknown function DUF82; Region: DUF82; pfam01927
103690007016	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690007017	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007018	AMIN domain; Region: AMIN; pfam11741
103690007019	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690007020	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690007021	N-terminal plug; other site
103690007022	ligand-binding site [chemical binding]; other site
103690007023	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690007024	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007025	siderophore binding site; other site
103690007026	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690007027	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690007028	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690007029	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690007030	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007031	AMIN domain; Region: AMIN; pfam11741
103690007032	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690007033	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
103690007034	putative active site [active]
103690007035	prevent-host-death family protein; Region: phd_fam; TIGR01552
103690007036	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690007037	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690007038	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690007039	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690007040	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007041	AMIN domain; Region: AMIN; pfam11741
103690007042	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690007043	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690007044	N-terminal plug; other site
103690007045	ligand-binding site [chemical binding]; other site
103690007046	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690007047	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007048	siderophore binding site; other site
103690007049	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690007050	putative dimer interface [polypeptide binding]; other site
103690007051	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690007052	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690007053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690007054	putative substrate translocation pore; other site
103690007055	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690007056	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007057	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
103690007058	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
103690007059	active site
103690007060	Na/Ca binding site [ion binding]; other site
103690007061	catalytic site [active]
103690007062	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
103690007063	putative anti-sigmaE protein; Provisional; Region: PRK13920
103690007064	Anti-sigma-K factor rskA; Region: RskA; pfam10099
103690007065	RNA polymerase sigma factor; Provisional; Region: PRK12519
103690007066	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690007067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690007068	DNA binding residues [nucleotide binding]
103690007069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
103690007070	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
103690007071	putative active site [active]
103690007072	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
103690007073	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
103690007074	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
103690007075	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
103690007076	catalytic residues [active]
103690007077	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
103690007078	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
103690007079	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
103690007080	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690007081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690007082	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
103690007083	Uncharacterized conserved protein [Function unknown]; Region: COG0398
103690007084	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690007085	Uncharacterized conserved protein [Function unknown]; Region: COG0398
103690007086	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690007087	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690007088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007089	AMIN domain; Region: AMIN; pfam11741
103690007090	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690007091	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690007092	N-terminal plug; other site
103690007093	ligand-binding site [chemical binding]; other site
103690007094	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690007095	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007096	siderophore binding site; other site
103690007097	AMIN domain; Region: AMIN; pfam11741
103690007098	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690007099	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690007100	N-terminal plug; other site
103690007101	ligand-binding site [chemical binding]; other site
103690007102	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690007103	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007104	siderophore binding site; other site
103690007105	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690007106	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007107	siderophore binding site; other site
103690007108	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
103690007109	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
103690007110	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
103690007111	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690007112	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690007113	putative substrate translocation pore; other site
103690007114	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
103690007115	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
103690007116	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
103690007117	active site
103690007118	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
103690007119	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690007120	Walker A/P-loop; other site
103690007121	ATP binding site [chemical binding]; other site
103690007122	Q-loop/lid; other site
103690007123	ABC transporter signature motif; other site
103690007124	Walker B; other site
103690007125	D-loop; other site
103690007126	H-loop/switch region; other site
103690007127	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
103690007128	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
103690007129	Walker A/P-loop; other site
103690007130	ATP binding site [chemical binding]; other site
103690007131	Q-loop/lid; other site
103690007132	ABC transporter signature motif; other site
103690007133	Walker B; other site
103690007134	D-loop; other site
103690007135	H-loop/switch region; other site
103690007136	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
103690007137	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627
103690007138	phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276
103690007139	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
103690007140	Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454
103690007141	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
103690007142	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
103690007143	active site
103690007144	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626
103690007145	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
103690007146	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690007147	Coenzyme A binding pocket [chemical binding]; other site
103690007148	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625
103690007149	Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnG; COG3624
103690007150	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
103690007151	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
103690007152	DNA-binding site [nucleotide binding]; DNA binding site
103690007153	UTRA domain; Region: UTRA; pfam07702
103690007154	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
103690007155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690007156	dimer interface [polypeptide binding]; other site
103690007157	conserved gate region; other site
103690007158	ABC-ATPase subunit interface; other site
103690007159	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
103690007160	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
103690007161	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
103690007162	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
103690007163	Walker A/P-loop; other site
103690007164	ATP binding site [chemical binding]; other site
103690007165	Q-loop/lid; other site
103690007166	ABC transporter signature motif; other site
103690007167	Walker B; other site
103690007168	D-loop; other site
103690007169	H-loop/switch region; other site
103690007170	S-layer homology domain; Region: SLH; pfam00395
103690007171	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690007172	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690007173	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
103690007174	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690007175	putative active site [active]
103690007176	putative metal binding site [ion binding]; other site
103690007177	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690007178	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690007179	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
103690007180	siderophore binding site; other site
103690007181	AMIN domain; Region: AMIN; pfam11741
103690007182	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690007183	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690007184	N-terminal plug; other site
103690007185	ligand-binding site [chemical binding]; other site
103690007186	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690007187	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690007188	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
103690007189	active site
103690007190	substrate binding site [chemical binding]; other site
103690007191	ATP binding site [chemical binding]; other site
103690007192	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007194	active site
103690007195	phosphorylation site [posttranslational modification]
103690007196	intermolecular recognition site; other site
103690007197	dimerization interface [polypeptide binding]; other site
103690007198	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007199	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007200	PAS domain S-box; Region: sensory_box; TIGR00229
103690007201	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007202	putative active site [active]
103690007203	heme pocket [chemical binding]; other site
103690007204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007205	PAS fold; Region: PAS_3; pfam08447
103690007206	putative active site [active]
103690007207	heme pocket [chemical binding]; other site
103690007208	PAS domain S-box; Region: sensory_box; TIGR00229
103690007209	PAS domain; Region: PAS; smart00091
103690007210	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007211	PAS fold; Region: PAS_3; pfam08447
103690007212	putative active site [active]
103690007213	heme pocket [chemical binding]; other site
103690007214	PAS domain S-box; Region: sensory_box; TIGR00229
103690007215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007216	putative active site [active]
103690007217	heme pocket [chemical binding]; other site
103690007218	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007219	PAS fold; Region: PAS_3; pfam08447
103690007220	putative active site [active]
103690007221	heme pocket [chemical binding]; other site
103690007222	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007223	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690007224	putative active site [active]
103690007225	heme pocket [chemical binding]; other site
103690007226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007227	putative active site [active]
103690007228	heme pocket [chemical binding]; other site
103690007229	PAS domain; Region: PAS_9; pfam13426
103690007230	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
103690007231	Histidine kinase; Region: HisKA_2; pfam07568
103690007232	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007233	ATP binding site [chemical binding]; other site
103690007234	Mg2+ binding site [ion binding]; other site
103690007235	G-X-G motif; other site
103690007236	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007238	active site
103690007239	phosphorylation site [posttranslational modification]
103690007240	intermolecular recognition site; other site
103690007241	dimerization interface [polypeptide binding]; other site
103690007242	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690007243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007244	active site
103690007245	phosphorylation site [posttranslational modification]
103690007246	intermolecular recognition site; other site
103690007247	dimerization interface [polypeptide binding]; other site
103690007248	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690007249	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007250	dimer interface [polypeptide binding]; other site
103690007251	phosphorylation site [posttranslational modification]
103690007252	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007253	ATP binding site [chemical binding]; other site
103690007254	G-X-G motif; other site
103690007255	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690007256	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690007257	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690007258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007259	Walker A motif; other site
103690007260	ATP binding site [chemical binding]; other site
103690007261	Walker B motif; other site
103690007262	arginine finger; other site
103690007263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690007264	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007265	Walker A motif; other site
103690007266	ATP binding site [chemical binding]; other site
103690007267	Walker B motif; other site
103690007268	arginine finger; other site
103690007269	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
103690007270	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690007271	P loop; other site
103690007272	Nucleotide binding site [chemical binding]; other site
103690007273	DTAP/Switch II; other site
103690007274	Switch I; other site
103690007275	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690007276	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
103690007277	DTAP/Switch II; other site
103690007278	Switch I; other site
103690007279	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
103690007280	Gas vesicle protein G; Region: GvpG; pfam05120
103690007281	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
103690007282	Gas vesicle protein K; Region: GvpK; pfam05121
103690007283	Gas vesicle protein; Region: Gas_vesicle; pfam00741
103690007284	Gas vesicle protein; Region: Gas_vesicle; pfam00741
103690007285	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
103690007286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007287	Walker A motif; other site
103690007288	ATP binding site [chemical binding]; other site
103690007289	Walker B motif; other site
103690007290	arginine finger; other site
103690007291	Gas vesicles protein GVPc repeated domain; Region: Gas_vesicle_C; pfam01304
103690007292	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
103690007293	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
103690007294	Inositol polyphosphate kinase; Region: IPK; cl12283
103690007295	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690007296	Uncharacterized conserved protein [Function unknown]; Region: COG3349
103690007297	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690007298	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007299	active site
103690007300	ATP binding site [chemical binding]; other site
103690007301	substrate binding site [chemical binding]; other site
103690007302	activation loop (A-loop); other site
103690007303	AAA ATPase domain; Region: AAA_16; pfam13191
103690007304	Predicted ATPase [General function prediction only]; Region: COG3899
103690007305	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007306	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007308	dimer interface [polypeptide binding]; other site
103690007309	phosphorylation site [posttranslational modification]
103690007310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007311	ATP binding site [chemical binding]; other site
103690007312	Mg2+ binding site [ion binding]; other site
103690007313	G-X-G motif; other site
103690007314	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690007315	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007316	active site
103690007317	ATP binding site [chemical binding]; other site
103690007318	substrate binding site [chemical binding]; other site
103690007319	activation loop (A-loop); other site
103690007320	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
103690007321	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690007322	dimerization interface [polypeptide binding]; other site
103690007323	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
103690007324	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
103690007325	membrane-bound complex binding site; other site
103690007326	heat shock protein HtpX; Provisional; Region: PRK03982
103690007327	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
103690007328	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
103690007329	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690007330	Ligand Binding Site [chemical binding]; other site
103690007331	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690007332	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
103690007333	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007334	GAF domain; Region: GAF_2; pfam13185
103690007335	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007336	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007338	putative active site [active]
103690007339	heme pocket [chemical binding]; other site
103690007340	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
103690007341	cyclase homology domain; Region: CHD; cd07302
103690007342	nucleotidyl binding site; other site
103690007343	metal binding site [ion binding]; metal-binding site
103690007344	dimer interface [polypeptide binding]; other site
103690007345	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
103690007346	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
103690007347	ATP binding site [chemical binding]; other site
103690007348	active site
103690007349	substrate binding site [chemical binding]; other site
103690007350	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
103690007351	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
103690007352	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
103690007353	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690007354	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
103690007355	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
103690007356	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
103690007357	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
103690007358	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
103690007359	active site
103690007360	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
103690007361	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
103690007362	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690007363	putative active site [active]
103690007364	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690007365	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690007366	cofactor binding site; other site
103690007367	DNA binding site [nucleotide binding]
103690007368	substrate interaction site [chemical binding]; other site
103690007369	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690007370	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690007371	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
103690007372	active site
103690007373	catalytic tetrad [active]
103690007374	Heme NO binding; Region: HNOB; pfam07700
103690007375	Heme NO binding associated; Region: HNOBA; pfam07701
103690007376	PAS fold; Region: PAS_7; pfam12860
103690007377	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007378	PAS fold; Region: PAS_3; pfam08447
103690007379	putative active site [active]
103690007380	heme pocket [chemical binding]; other site
103690007381	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007382	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007383	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690007384	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007385	dimer interface [polypeptide binding]; other site
103690007386	phosphorylation site [posttranslational modification]
103690007387	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007388	ATP binding site [chemical binding]; other site
103690007389	Mg2+ binding site [ion binding]; other site
103690007390	G-X-G motif; other site
103690007391	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690007392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007393	active site
103690007394	phosphorylation site [posttranslational modification]
103690007395	intermolecular recognition site; other site
103690007396	dimerization interface [polypeptide binding]; other site
103690007397	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690007398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007399	active site
103690007400	phosphorylation site [posttranslational modification]
103690007401	intermolecular recognition site; other site
103690007402	dimerization interface [polypeptide binding]; other site
103690007403	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
103690007404	putative binding surface; other site
103690007405	active site
103690007406	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007407	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007408	active site
103690007409	phosphorylation site [posttranslational modification]
103690007410	intermolecular recognition site; other site
103690007411	dimerization interface [polypeptide binding]; other site
103690007412	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
103690007413	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
103690007414	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007416	active site
103690007417	phosphorylation site [posttranslational modification]
103690007418	intermolecular recognition site; other site
103690007419	dimerization interface [polypeptide binding]; other site
103690007420	Protein kinase domain; Region: Pkinase; pfam00069
103690007421	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007422	active site
103690007423	substrate binding site [chemical binding]; other site
103690007424	ATP binding site [chemical binding]; other site
103690007425	activation loop (A-loop); other site
103690007426	AAA ATPase domain; Region: AAA_16; pfam13191
103690007427	Predicted ATPase [General function prediction only]; Region: COG3899
103690007428	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007429	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690007430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007431	dimer interface [polypeptide binding]; other site
103690007432	phosphorylation site [posttranslational modification]
103690007433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007434	ATP binding site [chemical binding]; other site
103690007435	Mg2+ binding site [ion binding]; other site
103690007436	G-X-G motif; other site
103690007437	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690007438	anti sigma factor interaction site; other site
103690007439	regulatory phosphorylation site [posttranslational modification]; other site
103690007440	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
103690007441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
103690007442	Mg2+ binding site [ion binding]; other site
103690007443	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690007444	anti sigma factor interaction site; other site
103690007445	regulatory phosphorylation site [posttranslational modification]; other site
103690007446	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
103690007447	Bacterial sugar transferase; Region: Bac_transf; pfam02397
103690007448	Uncharacterized conserved protein [Function unknown]; Region: COG5017
103690007449	UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707
103690007450	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
103690007451	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690007452	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690007453	active site
103690007454	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690007455	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690007456	active site
103690007457	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
103690007458	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690007459	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690007460	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690007461	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
103690007462	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
103690007463	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
103690007464	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
103690007465	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
103690007466	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690007467	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
103690007468	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
103690007469	active site
103690007470	putative DNA-binding cleft [nucleotide binding]; other site
103690007471	dimer interface [polypeptide binding]; other site
103690007472	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
103690007473	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
103690007474	phosphate binding site [ion binding]; other site
103690007475	putative substrate binding pocket [chemical binding]; other site
103690007476	dimer interface [polypeptide binding]; other site
103690007477	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
103690007478	similar to heterocyst-inhibiting signaling peptide; ORF_ID:asl2301
103690007479	Patatin [General function prediction only]; Region: COG3621
103690007480	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
103690007481	active site
103690007482	nucleophile elbow; other site
103690007483	dihydroorotase; Provisional; Region: PRK07575
103690007484	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
103690007485	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
103690007486	active site
103690007487	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
103690007488	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
103690007489	Catalytic site [active]
103690007490	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
103690007491	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
103690007492	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
103690007493	MOSC domain; Region: MOSC; pfam03473
103690007494	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007496	active site
103690007497	phosphorylation site [posttranslational modification]
103690007498	intermolecular recognition site; other site
103690007499	dimerization interface [polypeptide binding]; other site
103690007500	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690007501	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690007502	metal binding site [ion binding]; metal-binding site
103690007503	active site
103690007504	I-site; other site
103690007505	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690007506	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007508	active site
103690007509	phosphorylation site [posttranslational modification]
103690007510	intermolecular recognition site; other site
103690007511	dimerization interface [polypeptide binding]; other site
103690007512	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007513	dimer interface [polypeptide binding]; other site
103690007514	phosphorylation site [posttranslational modification]
103690007515	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007516	ATP binding site [chemical binding]; other site
103690007517	G-X-G motif; other site
103690007518	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
103690007519	4Fe-4S binding domain; Region: Fer4; pfam00037
103690007520	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
103690007521	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
103690007522	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
103690007523	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007524	Walker A motif; other site
103690007525	ATP binding site [chemical binding]; other site
103690007526	Walker B motif; other site
103690007527	negative regulator GrlR; Provisional; Region: PRK14051
103690007528	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
103690007529	RxxxH motif; other site
103690007530	agmatinase; Region: agmatinase; TIGR01230
103690007531	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
103690007532	putative active site [active]
103690007533	Mn binding site [ion binding]; other site
103690007534	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690007535	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690007536	Peptidase family M48; Region: Peptidase_M48; cl12018
103690007537	Circadian oscillating protein COP23; Region: COP23; pfam14218
103690007538	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
103690007539	ketol-acid reductoisomerase; Provisional; Region: PRK05479
103690007540	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
103690007541	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
103690007542	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690007543	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
103690007544	active site
103690007545	catalytic tetrad [active]
103690007546	Staphylococcal nuclease homologues; Region: SNc; smart00318
103690007547	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
103690007548	Catalytic site; other site
103690007549	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
103690007550	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
103690007551	Nitrogen regulatory protein P-II; Region: P-II; smart00938
103690007552	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690007553	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
103690007554	dimer interface [polypeptide binding]; other site
103690007555	active site
103690007556	metal binding site [ion binding]; metal-binding site
103690007557	glutathione binding site [chemical binding]; other site
103690007558	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
103690007559	Clp amino terminal domain; Region: Clp_N; pfam02861
103690007560	Clp amino terminal domain; Region: Clp_N; pfam02861
103690007561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007562	Walker A motif; other site
103690007563	ATP binding site [chemical binding]; other site
103690007564	Walker B motif; other site
103690007565	arginine finger; other site
103690007566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690007567	Walker A motif; other site
103690007568	ATP binding site [chemical binding]; other site
103690007569	Walker B motif; other site
103690007570	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
103690007571	heat shock protein 90; Provisional; Region: PRK05218
103690007572	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007573	ATP binding site [chemical binding]; other site
103690007574	Mg2+ binding site [ion binding]; other site
103690007575	G-X-G motif; other site
103690007576	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690007577	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690007578	ligand binding site [chemical binding]; other site
103690007579	flexible hinge region; other site
103690007580	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
103690007581	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
103690007582	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
103690007583	protein binding site [polypeptide binding]; other site
103690007584	allophycocyanin, beta subunit; Region: apcB; TIGR01337
103690007585	glutamine synthetase, type I; Region: GlnA; TIGR00653
103690007586	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
103690007587	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
103690007588	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
103690007589	dinuclear metal binding motif [ion binding]; other site
103690007590	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
103690007591	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690007592	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007593	active site
103690007594	ATP binding site [chemical binding]; other site
103690007595	substrate binding site [chemical binding]; other site
103690007596	activation loop (A-loop); other site
103690007597	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
103690007598	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
103690007599	putative NAD(P) binding site [chemical binding]; other site
103690007600	catalytic Zn binding site [ion binding]; other site
103690007601	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
103690007602	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
103690007603	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
103690007604	linker region; other site
103690007605	Triose-phosphate Transporter family; Region: TPT; pfam03151
103690007606	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
103690007607	EamA-like transporter family; Region: EamA; pfam00892
103690007608	heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245
103690007609	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
103690007610	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690007611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690007612	homodimer interface [polypeptide binding]; other site
103690007613	catalytic residue [active]
103690007614	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690007615	catalytic residues [active]
103690007616	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
103690007617	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
103690007618	large tegument protein UL36; Provisional; Region: PHA03247
103690007619	Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives [General function prediction only]; Region: COG5512
103690007620	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
103690007621	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
103690007622	substrate binding site [chemical binding]; other site
103690007623	oxyanion hole (OAH) forming residues; other site
103690007624	trimer interface [polypeptide binding]; other site
103690007625	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690007626	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690007627	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690007628	phosphoribulokinase; Provisional; Region: PRK07429
103690007629	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
103690007630	active site
103690007631	hypothetical protein; Reviewed; Region: PRK00024
103690007632	Helix-hairpin-helix motif; Region: HHH; pfam00633
103690007633	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
103690007634	MPN+ (JAMM) motif; other site
103690007635	Zinc-binding site [ion binding]; other site
103690007636	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690007637	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690007638	structural tetrad; other site
103690007639	light-harvesting-like protein 3; Provisional; Region: PLN00014
103690007640	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
103690007641	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
103690007642	hexamer interface [polypeptide binding]; other site
103690007643	ligand binding site [chemical binding]; other site
103690007644	putative active site [active]
103690007645	NAD(P) binding site [chemical binding]; other site
103690007646	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
103690007647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
103690007648	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
103690007649	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
103690007650	Walker A/P-loop; other site
103690007651	ATP binding site [chemical binding]; other site
103690007652	Q-loop/lid; other site
103690007653	ABC transporter signature motif; other site
103690007654	Walker B; other site
103690007655	D-loop; other site
103690007656	H-loop/switch region; other site
103690007657	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
103690007658	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
103690007659	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
103690007660	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
103690007661	active site
103690007662	Substrate binding site; other site
103690007663	Mg++ binding site; other site
103690007664	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
103690007665	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
103690007666	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
103690007667	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690007668	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
103690007669	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
103690007670	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690007671	catalytic residues [active]
103690007672	translation initiation factor IF-3; Region: infC; TIGR00168
103690007673	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
103690007674	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
103690007675	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690007676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690007677	Walker A/P-loop; other site
103690007678	ATP binding site [chemical binding]; other site
103690007679	Q-loop/lid; other site
103690007680	ABC transporter signature motif; other site
103690007681	Walker B; other site
103690007682	D-loop; other site
103690007683	H-loop/switch region; other site
103690007684	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
103690007685	ABC-2 type transporter; Region: ABC2_membrane; cl17235
103690007686	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
103690007687	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
103690007688	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690007689	catalytic triad [active]
103690007690	cobyric acid synthase; Provisional; Region: PRK00784
103690007691	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
103690007692	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
103690007693	catalytic triad [active]
103690007694	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690007695	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690007696	catalytic loop [active]
103690007697	iron binding site [ion binding]; other site
103690007698	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
103690007699	FOG: CBS domain [General function prediction only]; Region: COG0517
103690007700	FOG: CBS domain [General function prediction only]; Region: COG0517
103690007701	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
103690007702	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690007703	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007704	putative active site [active]
103690007705	heme pocket [chemical binding]; other site
103690007706	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007707	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690007708	putative active site [active]
103690007709	heme pocket [chemical binding]; other site
103690007710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007711	putative active site [active]
103690007712	heme pocket [chemical binding]; other site
103690007713	PAS fold; Region: PAS_4; pfam08448
103690007714	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
103690007715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007716	putative active site [active]
103690007717	heme pocket [chemical binding]; other site
103690007718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007719	dimer interface [polypeptide binding]; other site
103690007720	phosphorylation site [posttranslational modification]
103690007721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007722	ATP binding site [chemical binding]; other site
103690007723	Mg2+ binding site [ion binding]; other site
103690007724	G-X-G motif; other site
103690007725	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007727	active site
103690007728	phosphorylation site [posttranslational modification]
103690007729	intermolecular recognition site; other site
103690007730	dimerization interface [polypeptide binding]; other site
103690007731	Predicted integral membrane protein [Function unknown]; Region: COG5637
103690007732	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
103690007733	putative hydrophobic ligand binding site [chemical binding]; other site
103690007734	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
103690007735	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690007736	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
103690007737	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
103690007738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690007739	binding surface
103690007740	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690007741	TPR motif; other site
103690007742	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
103690007743	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
103690007744	putative NAD(P) binding site [chemical binding]; other site
103690007745	putative active site [active]
103690007746	hypothetical protein; Validated; Region: PRK07413
103690007747	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
103690007748	Walker A motif; other site
103690007749	homodimer interface [polypeptide binding]; other site
103690007750	ATP binding site [chemical binding]; other site
103690007751	hydroxycobalamin binding site [chemical binding]; other site
103690007752	Walker B motif; other site
103690007753	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
103690007754	homodimer interface [polypeptide binding]; other site
103690007755	Walker A motif; other site
103690007756	ATP binding site [chemical binding]; other site
103690007757	hydroxycobalamin binding site [chemical binding]; other site
103690007758	Walker B motif; other site
103690007759	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
103690007760	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690007761	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690007762	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690007763	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690007764	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690007765	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690007766	MltA specific insert domain; Region: MltA; cl08398
103690007767	4-aminobutyrate aminotransferase; Provisional; Region: PRK05769
103690007768	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
103690007769	inhibitor-cofactor binding pocket; inhibition site
103690007770	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690007771	catalytic residue [active]
103690007772	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690007773	putative active site [active]
103690007774	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690007775	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
103690007776	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
103690007777	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690007778	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
103690007779	flavodoxin FldA; Validated; Region: PRK09267
103690007780	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
103690007781	active site residue [active]
103690007782	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
103690007783	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
103690007784	Probable Catalytic site; other site
103690007785	Protein of unknown function, DUF547; Region: DUF547; pfam04784
103690007786	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
103690007787	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
103690007788	acyl-activating enzyme (AAE) consensus motif; other site
103690007789	active site
103690007790	AMP binding site [chemical binding]; other site
103690007791	CoA binding site [chemical binding]; other site
103690007792	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690007793	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007794	active site
103690007795	ATP binding site [chemical binding]; other site
103690007796	substrate binding site [chemical binding]; other site
103690007797	activation loop (A-loop); other site
103690007798	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690007799	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690007800	active site
103690007801	ATP binding site [chemical binding]; other site
103690007802	substrate binding site [chemical binding]; other site
103690007803	activation loop (A-loop); other site
103690007804	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
103690007805	Peptidase family M41; Region: Peptidase_M41; pfam01434
103690007806	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690007807	metal binding site [ion binding]; metal-binding site
103690007808	active site
103690007809	I-site; other site
103690007810	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
103690007811	metal-binding site [ion binding]
103690007812	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
103690007813	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
103690007814	motif 1; other site
103690007815	active site
103690007816	motif 2; other site
103690007817	motif 3; other site
103690007818	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
103690007819	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690007820	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690007821	active site
103690007822	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
103690007823	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
103690007824	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690007825	binding surface
103690007826	TPR motif; other site
103690007827	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690007828	binding surface
103690007829	TPR motif; other site
103690007830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690007831	binding surface
103690007832	TPR motif; other site
103690007833	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690007834	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690007835	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690007836	Peptidase M15; Region: Peptidase_M15_3; pfam08291
103690007837	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690007838	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007839	active site
103690007840	phosphorylation site [posttranslational modification]
103690007841	intermolecular recognition site; other site
103690007842	dimerization interface [polypeptide binding]; other site
103690007843	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690007844	DNA binding site [nucleotide binding]
103690007845	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690007846	putative binding surface; other site
103690007847	active site
103690007848	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007850	active site
103690007851	phosphorylation site [posttranslational modification]
103690007852	intermolecular recognition site; other site
103690007853	dimerization interface [polypeptide binding]; other site
103690007854	PAS fold; Region: PAS_4; pfam08448
103690007855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007856	putative active site [active]
103690007857	heme pocket [chemical binding]; other site
103690007858	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690007859	GAF domain; Region: GAF; pfam01590
103690007860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007861	PAS fold; Region: PAS_3; pfam08447
103690007862	putative active site [active]
103690007863	heme pocket [chemical binding]; other site
103690007864	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690007865	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690007866	putative active site [active]
103690007867	heme pocket [chemical binding]; other site
103690007868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690007869	dimer interface [polypeptide binding]; other site
103690007870	phosphorylation site [posttranslational modification]
103690007871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690007872	ATP binding site [chemical binding]; other site
103690007873	Mg2+ binding site [ion binding]; other site
103690007874	G-X-G motif; other site
103690007875	Response regulator receiver domain; Region: Response_reg; pfam00072
103690007876	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007877	active site
103690007878	phosphorylation site [posttranslational modification]
103690007879	intermolecular recognition site; other site
103690007880	dimerization interface [polypeptide binding]; other site
103690007881	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690007882	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007883	active site
103690007884	phosphorylation site [posttranslational modification]
103690007885	intermolecular recognition site; other site
103690007886	dimerization interface [polypeptide binding]; other site
103690007887	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690007888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690007889	active site
103690007890	phosphorylation site [posttranslational modification]
103690007891	intermolecular recognition site; other site
103690007892	dimerization interface [polypeptide binding]; other site
103690007893	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
103690007894	Family of unknown function (DUF490); Region: DUF490; pfam04357
103690007895	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
103690007896	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
103690007897	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
103690007898	putative active site [active]
103690007899	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
103690007900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690007901	dimer interface [polypeptide binding]; other site
103690007902	conserved gate region; other site
103690007903	putative PBP binding loops; other site
103690007904	ABC-ATPase subunit interface; other site
103690007905	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
103690007906	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
103690007907	Walker A/P-loop; other site
103690007908	ATP binding site [chemical binding]; other site
103690007909	Q-loop/lid; other site
103690007910	ABC transporter signature motif; other site
103690007911	Walker B; other site
103690007912	D-loop; other site
103690007913	H-loop/switch region; other site
103690007914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690007915	putative substrate translocation pore; other site
103690007916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
103690007917	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
103690007918	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
103690007919	dimer interface [polypeptide binding]; other site
103690007920	anticodon binding site; other site
103690007921	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
103690007922	homodimer interface [polypeptide binding]; other site
103690007923	motif 1; other site
103690007924	active site
103690007925	motif 2; other site
103690007926	GAD domain; Region: GAD; pfam02938
103690007927	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
103690007928	motif 3; other site
103690007929	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
103690007930	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690007931	putative active site [active]
103690007932	HEPN domain; Region: HEPN; cl00824
103690007933	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
103690007934	NAD(P) binding pocket [chemical binding]; other site
103690007935	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
103690007936	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
103690007937	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
103690007938	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
103690007939	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
103690007940	Walker A motif; other site
103690007941	ATP binding site [chemical binding]; other site
103690007942	Walker B motif; other site
103690007943	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
103690007944	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
103690007945	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
103690007946	Walker A motif; other site
103690007947	ATP binding site [chemical binding]; other site
103690007948	Walker B motif; other site
103690007949	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
103690007950	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
103690007951	dimer interface [polypeptide binding]; other site
103690007952	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
103690007953	molecular chaperone DnaK; Provisional; Region: PRK13411
103690007954	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
103690007955	nucleotide binding site [chemical binding]; other site
103690007956	NEF interaction site [polypeptide binding]; other site
103690007957	SBD interface [polypeptide binding]; other site
103690007958	chaperone protein DnaJ; Provisional; Region: PRK14293
103690007959	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690007960	HSP70 interaction site [polypeptide binding]; other site
103690007961	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
103690007962	Zn binding sites [ion binding]; other site
103690007963	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
103690007964	dimer interface [polypeptide binding]; other site
103690007965	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
103690007966	CPxP  motif; other site
103690007967	GTPase RsgA; Reviewed; Region: PRK12289
103690007968	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
103690007969	GTPase/Zn-binding domain interface [polypeptide binding]; other site
103690007970	GTP/Mg2+ binding site [chemical binding]; other site
103690007971	G4 box; other site
103690007972	G5 box; other site
103690007973	G1 box; other site
103690007974	Switch I region; other site
103690007975	G2 box; other site
103690007976	G3 box; other site
103690007977	Switch II region; other site
103690007978	Uncharacterized conserved protein [Function unknown]; Region: COG1543
103690007979	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
103690007980	active site
103690007981	substrate binding site [chemical binding]; other site
103690007982	catalytic site [active]
103690007983	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
103690007984	YxiJ-like protein; Region: YxiJ; pfam14176
103690007985	apocytochrome f; Reviewed; Region: PRK02693
103690007986	cytochrome f; Region: petA; CHL00037
103690007987	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
103690007988	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
103690007989	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
103690007990	cytochrome b subunit interaction site [polypeptide binding]; other site
103690007991	[2Fe-2S] cluster binding site [ion binding]; other site
103690007992	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
103690007993	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
103690007994	putative tRNA-binding site [nucleotide binding]; other site
103690007995	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
103690007996	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690007997	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690007998	active site
103690007999	alanine racemase; Reviewed; Region: alr; PRK00053
103690008000	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
103690008001	active site
103690008002	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
103690008003	dimer interface [polypeptide binding]; other site
103690008004	substrate binding site [chemical binding]; other site
103690008005	catalytic residues [active]
103690008006	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
103690008007	AAA ATPase domain; Region: AAA_16; pfam13191
103690008008	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
103690008009	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
103690008010	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
103690008011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690008012	Walker A motif; other site
103690008013	ATP binding site [chemical binding]; other site
103690008014	Walker B motif; other site
103690008015	Small integral membrane protein [Function unknown]; Region: COG5548
103690008016	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
103690008017	active site
103690008018	ATP binding site [chemical binding]; other site
103690008019	Phosphotransferase enzyme family; Region: APH; pfam01636
103690008020	substrate binding site [chemical binding]; other site
103690008021	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
103690008022	active site
103690008023	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690008024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690008025	S-adenosylmethionine binding site [chemical binding]; other site
103690008026	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
103690008027	nucleotide binding site/active site [active]
103690008028	HIT family signature motif; other site
103690008029	catalytic residue [active]
103690008030	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690008031	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690008032	putative active site [active]
103690008033	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
103690008034	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
103690008035	active site
103690008036	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
103690008037	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
103690008038	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
103690008039	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
103690008040	metal binding site 2 [ion binding]; metal-binding site
103690008041	putative DNA binding helix; other site
103690008042	metal binding site 1 [ion binding]; metal-binding site
103690008043	dimer interface [polypeptide binding]; other site
103690008044	structural Zn2+ binding site [ion binding]; other site
103690008045	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
103690008046	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
103690008047	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
103690008048	putative active site [active]
103690008049	catalytic triad [active]
103690008050	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690008051	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690008052	Transcriptional regulator [Transcription]; Region: LytR; COG1316
103690008053	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
103690008054	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
103690008055	PAS domain S-box; Region: sensory_box; TIGR00229
103690008056	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690008057	putative active site [active]
103690008058	heme pocket [chemical binding]; other site
103690008059	PAS domain S-box; Region: sensory_box; TIGR00229
103690008060	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690008061	putative active site [active]
103690008062	heme pocket [chemical binding]; other site
103690008063	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
103690008064	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690008065	dimer interface [polypeptide binding]; other site
103690008066	phosphorylation site [posttranslational modification]
103690008067	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690008068	ATP binding site [chemical binding]; other site
103690008069	Mg2+ binding site [ion binding]; other site
103690008070	G-X-G motif; other site
103690008071	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
103690008072	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
103690008073	active site
103690008074	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
103690008075	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
103690008076	active site
103690008077	(T/H)XGH motif; other site
103690008078	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
103690008079	nudix motif; other site
103690008080	NAD synthetase; Provisional; Region: PRK13981
103690008081	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
103690008082	multimer interface [polypeptide binding]; other site
103690008083	active site
103690008084	catalytic triad [active]
103690008085	protein interface 1 [polypeptide binding]; other site
103690008086	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
103690008087	homodimer interface [polypeptide binding]; other site
103690008088	NAD binding pocket [chemical binding]; other site
103690008089	ATP binding pocket [chemical binding]; other site
103690008090	Mg binding site [ion binding]; other site
103690008091	active-site loop [active]
103690008092	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690008093	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690008094	Walker A/P-loop; other site
103690008095	ATP binding site [chemical binding]; other site
103690008096	Q-loop/lid; other site
103690008097	ABC transporter signature motif; other site
103690008098	Walker B; other site
103690008099	D-loop; other site
103690008100	H-loop/switch region; other site
103690008101	TPR repeat; Region: TPR_11; pfam13414
103690008102	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690008103	binding surface
103690008104	TPR motif; other site
103690008105	TPR repeat; Region: TPR_11; pfam13414
103690008106	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690008107	TPR motif; other site
103690008108	TPR repeat; Region: TPR_11; pfam13414
103690008109	binding surface
103690008110	Uncharacterized conserved protein [Function unknown]; Region: COG0393
103690008111	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
103690008112	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
103690008113	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690008114	putative DNA binding site [nucleotide binding]; other site
103690008115	putative Zn2+ binding site [ion binding]; other site
103690008116	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
103690008117	putative ABC transporter; Region: ycf24; CHL00085
103690008118	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
103690008119	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
103690008120	Walker A/P-loop; other site
103690008121	ATP binding site [chemical binding]; other site
103690008122	Q-loop/lid; other site
103690008123	ABC transporter signature motif; other site
103690008124	Walker B; other site
103690008125	D-loop; other site
103690008126	H-loop/switch region; other site
103690008127	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
103690008128	FeS assembly protein SufD; Region: sufD; TIGR01981
103690008129	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
103690008130	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
103690008131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690008132	catalytic residue [active]
103690008133	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
103690008134	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
103690008135	active site
103690008136	homodimer interface [polypeptide binding]; other site
103690008137	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
103690008138	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
103690008139	Transposase [DNA replication, recombination, and repair]; Region: COG5433
103690008140	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
103690008141	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
103690008142	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
103690008143	protein binding site [polypeptide binding]; other site
103690008144	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
103690008145	Catalytic dyad [active]
103690008146	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
103690008147	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
103690008148	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
103690008149	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690008150	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690008151	active site
103690008152	ATP binding site [chemical binding]; other site
103690008153	substrate binding site [chemical binding]; other site
103690008154	activation loop (A-loop); other site
103690008155	putative pectinesterase; Region: PLN02432; cl01911
103690008156	Right handed beta helix region; Region: Beta_helix; pfam13229
103690008157	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
103690008158	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
103690008159	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
103690008160	catalytic triad [active]
103690008161	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
103690008162	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
103690008163	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690008164	catalytic residue [active]
103690008165	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
103690008166	proposed catalytic triad [active]
103690008167	active site nucleophile [active]
103690008168	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690008169	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690008170	GTP-binding protein LepA; Provisional; Region: PRK05433
103690008171	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
103690008172	G1 box; other site
103690008173	putative GEF interaction site [polypeptide binding]; other site
103690008174	GTP/Mg2+ binding site [chemical binding]; other site
103690008175	Switch I region; other site
103690008176	G2 box; other site
103690008177	G3 box; other site
103690008178	Switch II region; other site
103690008179	G4 box; other site
103690008180	G5 box; other site
103690008181	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
103690008182	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
103690008183	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
103690008184	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
103690008185	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
103690008186	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
103690008187	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
103690008188	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
103690008189	catalytic triad [active]
103690008190	Ferredoxin [Energy production and conversion]; Region: COG1146
103690008191	4Fe-4S binding domain; Region: Fer4; pfam00037
103690008192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690008193	non-specific DNA binding site [nucleotide binding]; other site
103690008194	salt bridge; other site
103690008195	sequence-specific DNA binding site [nucleotide binding]; other site
103690008196	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
103690008197	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
103690008198	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
103690008199	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
103690008200	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
103690008201	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
103690008202	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
103690008203	Subunit I/III interface [polypeptide binding]; other site
103690008204	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
103690008205	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
103690008206	putative catalytic residues [active]
103690008207	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
103690008208	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
103690008209	dimer interface [polypeptide binding]; other site
103690008210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690008211	catalytic residue [active]
103690008212	Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296
103690008213	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
103690008214	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
103690008215	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
103690008216	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
103690008217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690008218	dimer interface [polypeptide binding]; other site
103690008219	conserved gate region; other site
103690008220	putative PBP binding loops; other site
103690008221	ABC-ATPase subunit interface; other site
103690008222	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
103690008223	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
103690008224	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
103690008225	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
103690008226	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
103690008227	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
103690008228	TM-ABC transporter signature motif; other site
103690008229	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690008230	putative active site [active]
103690008231	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
103690008232	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
103690008233	TM-ABC transporter signature motif; other site
103690008234	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
103690008235	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
103690008236	Walker A/P-loop; other site
103690008237	ATP binding site [chemical binding]; other site
103690008238	Q-loop/lid; other site
103690008239	ABC transporter signature motif; other site
103690008240	Walker B; other site
103690008241	D-loop; other site
103690008242	H-loop/switch region; other site
103690008243	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690008244	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
103690008245	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
103690008246	Walker A/P-loop; other site
103690008247	ATP binding site [chemical binding]; other site
103690008248	Q-loop/lid; other site
103690008249	ABC transporter signature motif; other site
103690008250	Walker B; other site
103690008251	D-loop; other site
103690008252	H-loop/switch region; other site
103690008253	dihydrodipicolinate reductase; Provisional; Region: PRK00048
103690008254	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
103690008255	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
103690008256	precorrin-8X methylmutase; Validated; Region: PRK05953
103690008257	Precorrin-8X methylmutase; Region: CbiC; pfam02570
103690008258	Repair protein; Region: Repair_PSII; pfam04536
103690008259	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
103690008260	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690008261	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
103690008262	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690008263	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690008264	DNA binding residues [nucleotide binding]
103690008265	dimerization interface [polypeptide binding]; other site
103690008266	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
103690008267	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690008268	catalytic triad [active]
103690008269	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
103690008270	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
103690008271	propionate/acetate kinase; Provisional; Region: PRK12379
103690008272	transaldolase-like protein; Provisional; Region: PTZ00411
103690008273	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
103690008274	active site
103690008275	dimer interface [polypeptide binding]; other site
103690008276	catalytic residue [active]
103690008277	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
103690008278	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
103690008279	domain interfaces; other site
103690008280	active site
103690008281	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
103690008282	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
103690008283	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
103690008284	putative phosphoketolase; Provisional; Region: PRK05261
103690008285	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
103690008286	TPP-binding site; other site
103690008287	XFP C-terminal domain; Region: XFP_C; pfam09363
103690008288	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
103690008289	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
103690008290	Predicted transcriptional regulator [Transcription]; Region: COG3682
103690008291	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
103690008292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690008293	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
103690008294	catalytic motif [active]
103690008295	Catalytic residue [active]
103690008296	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
103690008297	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690008298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008299	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690008300	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008301	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690008302	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690008303	AMIN domain; Region: AMIN; pfam11741
103690008304	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690008305	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690008306	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008307	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
103690008308	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690008309	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008310	AMIN domain; Region: AMIN; pfam11741
103690008311	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690008312	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008313	N-terminal plug; other site
103690008314	ligand-binding site [chemical binding]; other site
103690008315	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690008316	putative dimer interface [polypeptide binding]; other site
103690008317	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690008318	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008319	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008320	siderophore binding site; other site
103690008321	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
103690008322	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
103690008323	Walker A/P-loop; other site
103690008324	ATP binding site [chemical binding]; other site
103690008325	Q-loop/lid; other site
103690008326	ABC transporter signature motif; other site
103690008327	Walker B; other site
103690008328	D-loop; other site
103690008329	H-loop/switch region; other site
103690008330	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
103690008331	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690008332	ABC-ATPase subunit  interface; other site
103690008333	dimer interface [polypeptide binding]; other site
103690008334	putative PBP binding regions; other site
103690008335	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
103690008336	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690008337	ABC-ATPase subunit  interface; other site
103690008338	dimer interface [polypeptide binding]; other site
103690008339	putative PBP binding regions; other site
103690008340	Helix-turn-helix domain; Region: HTH_18; pfam12833
103690008341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008342	AMIN domain; Region: AMIN; pfam11741
103690008343	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008344	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008345	N-terminal plug; other site
103690008346	ligand-binding site [chemical binding]; other site
103690008347	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690008348	putative dimer interface [polypeptide binding]; other site
103690008349	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690008350	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008351	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008352	siderophore binding site; other site
103690008353	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690008354	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008355	AMIN domain; Region: AMIN; pfam11741
103690008356	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008357	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008358	N-terminal plug; other site
103690008359	ligand-binding site [chemical binding]; other site
103690008360	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008361	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008362	siderophore binding site; other site
103690008363	Predicted metal-binding protein [Function unknown]; Region: COG5469
103690008364	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690008365	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008366	AMIN domain; Region: AMIN; pfam11741
103690008367	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008368	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008369	N-terminal plug; other site
103690008370	ligand-binding site [chemical binding]; other site
103690008371	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008372	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008373	siderophore binding site; other site
103690008374	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
103690008375	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
103690008376	NADP binding site [chemical binding]; other site
103690008377	Predicted transcriptional regulators [Transcription]; Region: COG1733
103690008378	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
103690008379	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690008380	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008381	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690008382	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008383	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690008384	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008385	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690008386	putative dimer interface [polypeptide binding]; other site
103690008387	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690008388	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008389	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008390	siderophore binding site; other site
103690008391	AMIN domain; Region: AMIN; pfam11741
103690008392	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008393	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008394	N-terminal plug; other site
103690008395	ligand-binding site [chemical binding]; other site
103690008396	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690008397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008398	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
103690008399	CAAX protease self-immunity; Region: Abi; pfam02517
103690008400	Predicted membrane protein [Function unknown]; Region: COG2510
103690008401	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690008402	putative dimer interface [polypeptide binding]; other site
103690008403	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690008404	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008405	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008406	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690008407	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690008408	AMIN domain; Region: AMIN; pfam11741
103690008409	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690008410	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690008411	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008412	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690008413	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690008414	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
103690008415	Walker A/P-loop; other site
103690008416	ATP binding site [chemical binding]; other site
103690008417	Q-loop/lid; other site
103690008418	ABC transporter signature motif; other site
103690008419	Walker B; other site
103690008420	D-loop; other site
103690008421	H-loop/switch region; other site
103690008422	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690008423	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690008424	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690008425	Walker A/P-loop; other site
103690008426	ATP binding site [chemical binding]; other site
103690008427	Q-loop/lid; other site
103690008428	ABC transporter signature motif; other site
103690008429	Walker B; other site
103690008430	D-loop; other site
103690008431	H-loop/switch region; other site
103690008432	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008433	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690008434	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690008435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690008436	AMIN domain; Region: AMIN; pfam11741
103690008437	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008438	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008439	N-terminal plug; other site
103690008440	ligand-binding site [chemical binding]; other site
103690008441	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690008442	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690008443	siderophore binding site; other site
103690008444	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
103690008445	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
103690008446	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
103690008447	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
103690008448	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
103690008449	active site
103690008450	interdomain interaction site; other site
103690008451	putative metal-binding site [ion binding]; other site
103690008452	nucleotide binding site [chemical binding]; other site
103690008453	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
103690008454	domain I; other site
103690008455	DNA binding groove [nucleotide binding]
103690008456	phosphate binding site [ion binding]; other site
103690008457	domain II; other site
103690008458	domain III; other site
103690008459	nucleotide binding site [chemical binding]; other site
103690008460	catalytic site [active]
103690008461	domain IV; other site
103690008462	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
103690008463	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
103690008464	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
103690008465	FAD binding pocket [chemical binding]; other site
103690008466	FAD binding motif [chemical binding]; other site
103690008467	phosphate binding motif [ion binding]; other site
103690008468	beta-alpha-beta structure motif; other site
103690008469	NAD binding pocket [chemical binding]; other site
103690008470	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690008471	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690008472	active site
103690008473	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690008474	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
103690008475	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690008476	putative NADP binding site [chemical binding]; other site
103690008477	active site
103690008478	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008479	Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001
103690008480	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
103690008481	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690008482	catalytic residue [active]
103690008483	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
103690008484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690008485	S-adenosylmethionine binding site [chemical binding]; other site
103690008486	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
103690008487	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
103690008488	Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843
103690008489	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
103690008490	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
103690008491	putative NAD(P) binding site [chemical binding]; other site
103690008492	active site
103690008493	putative substrate binding site [chemical binding]; other site
103690008494	Condensation domain; Region: Condensation; pfam00668
103690008495	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008496	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008497	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
103690008498	acyl-activating enzyme (AAE) consensus motif; other site
103690008499	AMP binding site [chemical binding]; other site
103690008500	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008501	Condensation domain; Region: Condensation; pfam00668
103690008502	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008503	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
103690008504	acyl-activating enzyme (AAE) consensus motif; other site
103690008505	AMP binding site [chemical binding]; other site
103690008506	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008507	Condensation domain; Region: Condensation; pfam00668
103690008508	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008509	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008510	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
103690008511	acyl-activating enzyme (AAE) consensus motif; other site
103690008512	AMP binding site [chemical binding]; other site
103690008513	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008514	Condensation domain; Region: Condensation; pfam00668
103690008515	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008516	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008517	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
103690008518	acyl-activating enzyme (AAE) consensus motif; other site
103690008519	AMP binding site [chemical binding]; other site
103690008520	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008521	Condensation domain; Region: Condensation; pfam00668
103690008522	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008523	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
103690008524	Condensation domain; Region: Condensation; pfam00668
103690008525	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008526	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008527	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115
103690008528	acyl-activating enzyme (AAE) consensus motif; other site
103690008529	AMP binding site [chemical binding]; other site
103690008530	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008531	Condensation domain; Region: Condensation; pfam00668
103690008532	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008533	Nonribosomal peptide synthase; Region: NRPS; pfam08415
103690008534	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
103690008535	acyl-activating enzyme (AAE) consensus motif; other site
103690008536	AMP binding site [chemical binding]; other site
103690008537	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
103690008538	putative FMN binding site [chemical binding]; other site
103690008539	NADPH bind site [chemical binding]; other site
103690008540	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
103690008541	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008542	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690008543	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690008544	active site
103690008545	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690008546	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
103690008547	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690008548	putative NADP binding site [chemical binding]; other site
103690008549	active site
103690008550	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008551	Condensation domain; Region: Condensation; pfam00668
103690008552	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008553	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
103690008554	acyl-activating enzyme (AAE) consensus motif; other site
103690008555	AMP binding site [chemical binding]; other site
103690008556	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008557	Condensation domain; Region: Condensation; pfam00668
103690008558	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008559	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
103690008560	acyl-activating enzyme (AAE) consensus motif; other site
103690008561	AMP binding site [chemical binding]; other site
103690008562	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008563	Condensation domain; Region: Condensation; pfam00668
103690008564	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008565	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008566	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
103690008567	acyl-activating enzyme (AAE) consensus motif; other site
103690008568	AMP binding site [chemical binding]; other site
103690008569	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008570	Condensation domain; Region: Condensation; pfam00668
103690008571	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008572	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
103690008573	Condensation domain; Region: Condensation; pfam00668
103690008574	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008575	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
103690008576	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
103690008577	acyl-activating enzyme (AAE) consensus motif; other site
103690008578	AMP binding site [chemical binding]; other site
103690008579	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690008580	Condensation domain; Region: Condensation; pfam00668
103690008581	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
103690008582	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
103690008583	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
103690008584	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
103690008585	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
103690008586	DevC protein; Region: devC; TIGR01185
103690008587	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690008588	FtsX-like permease family; Region: FtsX; pfam02687
103690008589	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690008590	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690008591	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690008592	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
103690008593	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
103690008594	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690008595	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690008596	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690008597	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690008598	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
103690008599	Beta-lactamase; Region: Beta-lactamase; pfam00144
103690008600	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
103690008601	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
103690008602	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
103690008603	Predicted membrane protein [Function unknown]; Region: COG4280
103690008604	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
103690008605	putative dimer interface [polypeptide binding]; other site
103690008606	putative [2Fe-2S] cluster binding site [ion binding]; other site
103690008607	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
103690008608	Protein of unknown function (DUF3102); Region: DUF3102; pfam11300
103690008609	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
103690008610	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
103690008611	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
103690008612	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
103690008613	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690008614	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690008615	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008616	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008617	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
103690008618	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
103690008619	Zn binding site [ion binding]; other site
103690008620	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
103690008621	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
103690008622	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690008623	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
103690008624	Walker A/P-loop; other site
103690008625	ATP binding site [chemical binding]; other site
103690008626	Q-loop/lid; other site
103690008627	ABC transporter signature motif; other site
103690008628	Walker B; other site
103690008629	D-loop; other site
103690008630	H-loop/switch region; other site
103690008631	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690008632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690008633	putative substrate translocation pore; other site
103690008634	AMIN domain; Region: AMIN; pfam11741
103690008635	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690008636	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690008637	N-terminal plug; other site
103690008638	ligand-binding site [chemical binding]; other site
103690008639	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690008640	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690008641	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690008642	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690008643	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690008644	ligand binding site [chemical binding]; other site
103690008645	flexible hinge region; other site
103690008646	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690008647	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
103690008648	putative active site [active]
103690008649	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690008650	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690008651	Walker A/P-loop; other site
103690008652	ATP binding site [chemical binding]; other site
103690008653	Q-loop/lid; other site
103690008654	ABC transporter signature motif; other site
103690008655	Walker B; other site
103690008656	D-loop; other site
103690008657	H-loop/switch region; other site
103690008658	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690008659	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
103690008660	acyl-CoA synthetase; Validated; Region: PRK05850
103690008661	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
103690008662	acyl-activating enzyme (AAE) consensus motif; other site
103690008663	active site
103690008664	cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207
103690008665	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
103690008666	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
103690008667	active site
103690008668	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690008669	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690008670	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690008671	active site
103690008672	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690008673	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
103690008674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690008675	S-adenosylmethionine binding site [chemical binding]; other site
103690008676	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690008677	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
103690008678	Enoylreductase; Region: PKS_ER; smart00829
103690008679	NAD(P) binding site [chemical binding]; other site
103690008680	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
103690008681	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690008682	putative NADP binding site [chemical binding]; other site
103690008683	active site
103690008684	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690008685	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690008686	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690008687	active site
103690008688	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690008689	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
103690008690	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690008691	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690008692	S-adenosylmethionine binding site [chemical binding]; other site
103690008693	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690008694	enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195
103690008695	Enoylreductase; Region: PKS_ER; smart00829
103690008696	NAD(P) binding site [chemical binding]; other site
103690008697	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
103690008698	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690008699	putative NADP binding site [chemical binding]; other site
103690008700	active site
103690008701	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690008702	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690008703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690008704	motif II; other site
103690008705	Protein kinase domain; Region: Pkinase; pfam00069
103690008706	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690008707	active site
103690008708	ATP binding site [chemical binding]; other site
103690008709	substrate binding site [chemical binding]; other site
103690008710	activation loop (A-loop); other site
103690008711	AAA ATPase domain; Region: AAA_16; pfam13191
103690008712	Predicted ATPase [General function prediction only]; Region: COG3899
103690008713	Walker A motif; other site
103690008714	ATP binding site [chemical binding]; other site
103690008715	Walker B motif; other site
103690008716	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690008717	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690008718	PAS fold; Region: PAS_4; pfam08448
103690008719	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690008720	putative active site [active]
103690008721	heme pocket [chemical binding]; other site
103690008722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690008723	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690008724	ATP binding site [chemical binding]; other site
103690008725	Mg2+ binding site [ion binding]; other site
103690008726	G-X-G motif; other site
103690008727	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690008728	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690008729	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
103690008730	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
103690008731	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690008732	putative active site [active]
103690008733	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
103690008734	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690008735	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
103690008736	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690008737	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
103690008738	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690008739	Vps51/Vps67; Region: Vps51; pfam08700
103690008740	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
103690008741	HsdM N-terminal domain; Region: HsdM_N; pfam12161
103690008742	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690008743	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690008744	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690008745	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690008746	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690008747	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690008748	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690008749	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690008750	GAF domain; Region: GAF; pfam01590
103690008751	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690008752	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690008753	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690008754	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690008755	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690008756	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690008757	dimer interface [polypeptide binding]; other site
103690008758	phosphorylation site [posttranslational modification]
103690008759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690008760	ATP binding site [chemical binding]; other site
103690008761	Mg2+ binding site [ion binding]; other site
103690008762	G-X-G motif; other site
103690008763	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
103690008764	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690008765	P loop; other site
103690008766	Nucleotide binding site [chemical binding]; other site
103690008767	DTAP/Switch II; other site
103690008768	Switch I; other site
103690008769	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690008770	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
103690008771	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
103690008772	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690008773	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690008774	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
103690008775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
103690008776	Predicted permeases [General function prediction only]; Region: COG0679
103690008777	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690008778	HSP70 interaction site [polypeptide binding]; other site
103690008779	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
103690008780	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
103690008781	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
103690008782	tetramer interface [polypeptide binding]; other site
103690008783	TPP-binding site [chemical binding]; other site
103690008784	heterodimer interface [polypeptide binding]; other site
103690008785	phosphorylation loop region [posttranslational modification]
103690008786	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
103690008787	active site
103690008788	catalytic residues [active]
103690008789	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
103690008790	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
103690008791	putative active site [active]
103690008792	putative dimer interface [polypeptide binding]; other site
103690008793	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
103690008794	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690008795	Uncharacterized conserved protein [Function unknown]; Region: COG4301
103690008796	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
103690008797	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
103690008798	Predicted RNA binding protein (dsRBD-like fold), HicA family    [General function prediction only]; Region: COG1724
103690008799	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
103690008800	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
103690008801	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690008802	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
103690008803	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
103690008804	catalytic triad [active]
103690008805	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690008806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690008807	Probable transposase; Region: OrfB_IS605; pfam01385
103690008808	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690008809	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
103690008810	putative ADP-binding pocket [chemical binding]; other site
103690008811	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690008812	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690008813	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
103690008814	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
103690008815	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
103690008816	dimer interface [polypeptide binding]; other site
103690008817	catalytic triad [active]
103690008818	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
103690008819	Cupin domain; Region: Cupin_2; cl17218
103690008820	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
103690008821	DNA photolyase; Region: DNA_photolyase; pfam00875
103690008822	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
103690008823	Response regulator receiver domain; Region: Response_reg; pfam00072
103690008824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690008825	active site
103690008826	phosphorylation site [posttranslational modification]
103690008827	intermolecular recognition site; other site
103690008828	dimerization interface [polypeptide binding]; other site
103690008829	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
103690008830	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
103690008831	GIY-YIG motif/motif A; other site
103690008832	active site
103690008833	catalytic site [active]
103690008834	putative DNA binding site [nucleotide binding]; other site
103690008835	metal binding site [ion binding]; metal-binding site
103690008836	UvrB/uvrC motif; Region: UVR; pfam02151
103690008837	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
103690008838	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
103690008839	Predicted membrane protein [Function unknown]; Region: COG4244
103690008840	Predicted membrane protein [Function unknown]; Region: COG4244
103690008841	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
103690008842	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
103690008843	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
103690008844	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
103690008845	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
103690008846	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
103690008847	four helix bundle protein; Region: TIGR02436
103690008848	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
103690008849	Subunit I/III interface [polypeptide binding]; other site
103690008850	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
103690008851	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
103690008852	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
103690008853	RNA binding surface [nucleotide binding]; other site
103690008854	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
103690008855	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690008856	membrane-bound complex binding site; other site
103690008857	hinge residues; other site
103690008858	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690008859	dimerization interface [polypeptide binding]; other site
103690008860	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690008861	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690008862	dimer interface [polypeptide binding]; other site
103690008863	phosphorylation site [posttranslational modification]
103690008864	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690008865	ATP binding site [chemical binding]; other site
103690008866	Mg2+ binding site [ion binding]; other site
103690008867	G-X-G motif; other site
103690008868	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690008869	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690008870	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690008871	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
103690008872	ATP-grasp domain; Region: ATP-grasp; pfam02222
103690008873	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690008874	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690008875	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690008876	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690008877	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690008878	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690008879	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690008880	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690008881	Predicted membrane protein [Function unknown]; Region: COG1950
103690008882	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
103690008883	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
103690008884	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008885	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690008886	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008887	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008888	Ankyrin repeat; Region: Ank; pfam00023
103690008889	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008890	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690008891	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008892	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690008893	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690008894	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690008895	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
103690008896	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
103690008897	NADH(P)-binding; Region: NAD_binding_10; pfam13460
103690008898	NAD(P) binding site [chemical binding]; other site
103690008899	putative active site [active]
103690008900	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
103690008901	N-acetyl-D-glucosamine binding site [chemical binding]; other site
103690008902	catalytic residue [active]
103690008903	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
103690008904	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690008905	GAF domain; Region: GAF; cl17456
103690008906	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
103690008907	putative homodimer interface [polypeptide binding]; other site
103690008908	putative homotetramer interface [polypeptide binding]; other site
103690008909	putative metal binding site [ion binding]; other site
103690008910	putative homodimer-homodimer interface [polypeptide binding]; other site
103690008911	putative allosteric switch controlling residues; other site
103690008912	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
103690008913	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
103690008914	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
103690008915	protein binding site [polypeptide binding]; other site
103690008916	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
103690008917	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690008918	active site
103690008919	catalytic tetrad [active]
103690008920	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690008921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690008922	active site
103690008923	ATP binding site [chemical binding]; other site
103690008924	substrate binding site [chemical binding]; other site
103690008925	activation loop (A-loop); other site
103690008926	hydrolase, alpha/beta fold family protein; Region: PLN02824
103690008927	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690008928	Protein of function (DUF2518); Region: DUF2518; pfam10726
103690008929	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
103690008930	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
103690008931	putative active site [active]
103690008932	metal binding site [ion binding]; metal-binding site
103690008933	aspartate aminotransferase; Provisional; Region: PRK05942
103690008934	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690008935	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690008936	homodimer interface [polypeptide binding]; other site
103690008937	catalytic residue [active]
103690008938	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690008939	dimerization interface [polypeptide binding]; other site
103690008940	putative DNA binding site [nucleotide binding]; other site
103690008941	putative Zn2+ binding site [ion binding]; other site
103690008942	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690008943	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690008944	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690008945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690008946	TPR repeat; Region: TPR_11; pfam13414
103690008947	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690008948	binding surface
103690008949	TPR motif; other site
103690008950	Putative transcription activator [Transcription]; Region: TenA; COG0819
103690008951	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
103690008952	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
103690008953	Ligand binding site; other site
103690008954	Putative Catalytic site; other site
103690008955	DXD motif; other site
103690008956	Predicted membrane protein [Function unknown]; Region: COG2246
103690008957	GtrA-like protein; Region: GtrA; pfam04138
103690008958	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
103690008959	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690008960	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690008961	dimer interface [polypeptide binding]; other site
103690008962	phosphorylation site [posttranslational modification]
103690008963	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690008964	ATP binding site [chemical binding]; other site
103690008965	Mg2+ binding site [ion binding]; other site
103690008966	G-X-G motif; other site
103690008967	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690008968	Homeodomain-like domain; Region: HTH_23; pfam13384
103690008969	Winged helix-turn helix; Region: HTH_33; pfam13592
103690008970	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690008971	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690008972	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
103690008973	hydroxyglutarate oxidase; Provisional; Region: PRK11728
103690008974	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690008975	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690008976	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
103690008977	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
103690008978	active site
103690008979	interdomain interaction site; other site
103690008980	putative metal-binding site [ion binding]; other site
103690008981	nucleotide binding site [chemical binding]; other site
103690008982	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
103690008983	domain I; other site
103690008984	phosphate binding site [ion binding]; other site
103690008985	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
103690008986	domain II; other site
103690008987	domain III; other site
103690008988	nucleotide binding site [chemical binding]; other site
103690008989	DNA binding groove [nucleotide binding]
103690008990	catalytic site [active]
103690008991	domain IV; other site
103690008992	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
103690008993	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
103690008994	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
103690008995	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
103690008996	Dehydroquinase class II; Region: DHquinase_II; pfam01220
103690008997	trimer interface [polypeptide binding]; other site
103690008998	active site
103690008999	dimer interface [polypeptide binding]; other site
103690009000	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
103690009001	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
103690009002	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
103690009003	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
103690009004	Zn2+ binding site [ion binding]; other site
103690009005	Mg2+ binding site [ion binding]; other site
103690009006	Uncharacterized conserved protein [Function unknown]; Region: COG3349
103690009007	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690009008	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
103690009009	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
103690009010	iron-sulfur cluster [ion binding]; other site
103690009011	[2Fe-2S] cluster binding site [ion binding]; other site
103690009012	Uncharacterized conserved protein [Function unknown]; Region: COG3349
103690009013	Protein of unknown function (DUF433); Region: DUF433; cl01030
103690009014	NB-ARC domain; Region: NB-ARC; pfam00931
103690009015	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009016	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009017	TPR motif; other site
103690009018	binding surface
103690009019	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009020	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009021	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009022	binding surface
103690009023	TPR motif; other site
103690009024	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009025	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009026	binding surface
103690009027	TPR motif; other site
103690009028	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009029	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009030	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009031	binding surface
103690009032	TPR motif; other site
103690009033	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009034	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009035	Tetratricopeptide repeat; Region: TPR_10; pfam13374
103690009036	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690009037	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690009038	structural tetrad; other site
103690009039	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690009040	structural tetrad; other site
103690009041	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690009042	WD40 repeats; Region: WD40; smart00320
103690009043	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
103690009044	CSLREA domain; Region: CSLREA_Nterm; TIGR04214
103690009045	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
103690009046	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
103690009047	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690009048	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690009049	Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase [General function prediction only]; Region: COG3576
103690009050	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
103690009051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690009052	non-specific DNA binding site [nucleotide binding]; other site
103690009053	salt bridge; other site
103690009054	sequence-specific DNA binding site [nucleotide binding]; other site
103690009055	AAA ATPase domain; Region: AAA_16; pfam13191
103690009056	NB-ARC domain; Region: NB-ARC; pfam00931
103690009057	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690009058	WD40 repeats; Region: WD40; smart00320
103690009059	WD domain, G-beta repeat; Region: WD40; pfam00400
103690009060	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690009061	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690009062	structural tetrad; other site
103690009063	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690009064	structural tetrad; other site
103690009065	Predicted membrane protein [Function unknown]; Region: COG2149
103690009066	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
103690009067	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
103690009068	dimer interface [polypeptide binding]; other site
103690009069	PYR/PP interface [polypeptide binding]; other site
103690009070	TPP binding site [chemical binding]; other site
103690009071	substrate binding site [chemical binding]; other site
103690009072	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
103690009073	Domain of unknown function; Region: EKR; smart00890
103690009074	4Fe-4S binding domain; Region: Fer4_6; pfam12837
103690009075	4Fe-4S binding domain; Region: Fer4; pfam00037
103690009076	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
103690009077	TPP-binding site [chemical binding]; other site
103690009078	dimer interface [polypeptide binding]; other site
103690009079	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
103690009080	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
103690009081	Uncharacterized small protein [Function unknown]; Region: COG2886
103690009082	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
103690009083	putative homodimer interface [polypeptide binding]; other site
103690009084	putative active site pocket [active]
103690009085	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
103690009086	S-formylglutathione hydrolase; Region: PLN02442
103690009087	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
103690009088	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690009089	putative active site [active]
103690009090	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
103690009091	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
103690009092	substrate binding site [chemical binding]; other site
103690009093	catalytic Zn binding site [ion binding]; other site
103690009094	NAD binding site [chemical binding]; other site
103690009095	structural Zn binding site [ion binding]; other site
103690009096	dimer interface [polypeptide binding]; other site
103690009097	Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase [Amino acid transport and metabolism]; Region: COG3977
103690009098	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690009099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690009100	homodimer interface [polypeptide binding]; other site
103690009101	catalytic residue [active]
103690009102	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
103690009103	RimM N-terminal domain; Region: RimM; pfam01782
103690009104	PRC-barrel domain; Region: PRC; pfam05239
103690009105	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690009106	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690009107	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
103690009108	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
103690009109	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
103690009110	Protein of unknown function, DUF608; Region: DUF608; pfam04685
103690009111	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690009112	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690009113	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
103690009114	putative active site [active]
103690009115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690009116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690009117	Walker A/P-loop; other site
103690009118	ATP binding site [chemical binding]; other site
103690009119	Q-loop/lid; other site
103690009120	ABC transporter signature motif; other site
103690009121	Walker B; other site
103690009122	D-loop; other site
103690009123	H-loop/switch region; other site
103690009124	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009125	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009126	active site
103690009127	phosphorylation site [posttranslational modification]
103690009128	intermolecular recognition site; other site
103690009129	dimerization interface [polypeptide binding]; other site
103690009130	VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464
103690009131	metal ion-dependent adhesion site (MIDAS); other site
103690009132	Protein phosphatase 2C; Region: PP2C_2; pfam13672
103690009133	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690009134	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
103690009135	substrate binding site [chemical binding]; other site
103690009136	activation loop (A-loop); other site
103690009137	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009138	binding surface
103690009139	TPR repeat; Region: TPR_11; pfam13414
103690009140	TPR motif; other site
103690009141	TPR repeat; Region: TPR_11; pfam13414
103690009142	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009143	TPR motif; other site
103690009144	TPR repeat; Region: TPR_11; pfam13414
103690009145	binding surface
103690009146	TPR repeat; Region: TPR_11; pfam13414
103690009147	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
103690009148	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
103690009149	substrate binding site; other site
103690009150	Predicted dehydrogenase [General function prediction only]; Region: COG0579
103690009151	hydroxyglutarate oxidase; Provisional; Region: PRK11728
103690009152	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
103690009153	extended (e) SDRs; Region: SDR_e; cd08946
103690009154	NAD(P) binding site [chemical binding]; other site
103690009155	active site
103690009156	substrate binding site [chemical binding]; other site
103690009157	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009158	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
103690009159	active site
103690009160	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
103690009161	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
103690009162	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
103690009163	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
103690009164	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009165	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
103690009166	putative ADP-binding pocket [chemical binding]; other site
103690009167	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690009168	Chain length determinant protein; Region: Wzz; cl15801
103690009169	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690009170	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
103690009171	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690009172	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690009173	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690009174	Walker A/P-loop; other site
103690009175	ATP binding site [chemical binding]; other site
103690009176	Q-loop/lid; other site
103690009177	ABC transporter signature motif; other site
103690009178	Walker B; other site
103690009179	D-loop; other site
103690009180	H-loop/switch region; other site
103690009181	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009182	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690009183	active site
103690009184	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690009185	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
103690009186	active site
103690009187	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690009188	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690009189	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009190	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690009191	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690009192	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009193	active site
103690009194	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
103690009195	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
103690009196	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
103690009197	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
103690009198	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
103690009199	active site
103690009200	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
103690009201	GMP synthase; Reviewed; Region: guaA; PRK00074
103690009202	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
103690009203	AMP/PPi binding site [chemical binding]; other site
103690009204	candidate oxyanion hole; other site
103690009205	catalytic triad [active]
103690009206	potential glutamine specificity residues [chemical binding]; other site
103690009207	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
103690009208	ATP Binding subdomain [chemical binding]; other site
103690009209	Ligand Binding sites [chemical binding]; other site
103690009210	Dimerization subdomain; other site
103690009211	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
103690009212	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
103690009213	CP12 domain; Region: CP12; pfam02672
103690009214	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
103690009215	FIST N domain; Region: FIST; pfam08495
103690009216	FIST C domain; Region: FIST_C; pfam10442
103690009217	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
103690009218	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690009219	active site
103690009220	metal binding site [ion binding]; metal-binding site
103690009221	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
103690009222	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
103690009223	NAD binding site [chemical binding]; other site
103690009224	homodimer interface [polypeptide binding]; other site
103690009225	active site
103690009226	substrate binding site [chemical binding]; other site
103690009227	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
103690009228	Bacterial sugar transferase; Region: Bac_transf; pfam02397
103690009229	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690009230	Chain length determinant protein; Region: Wzz; pfam02706
103690009231	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
103690009232	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690009233	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690009234	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
103690009235	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
103690009236	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
103690009237	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
103690009238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009239	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690009240	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009241	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690009242	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009243	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
103690009244	putative ADP-binding pocket [chemical binding]; other site
103690009245	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690009246	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690009247	S-adenosylmethionine binding site [chemical binding]; other site
103690009248	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
103690009249	putative metal binding site; other site
103690009250	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
103690009251	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
103690009252	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
103690009253	Protein of unknown function (DUF565); Region: DUF565; pfam04483
103690009254	Predicted kinase [General function prediction only]; Region: COG4240
103690009255	active site
103690009256	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009258	active site
103690009259	phosphorylation site [posttranslational modification]
103690009260	intermolecular recognition site; other site
103690009261	dimerization interface [polypeptide binding]; other site
103690009262	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690009263	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690009264	metal binding site [ion binding]; metal-binding site
103690009265	active site
103690009266	I-site; other site
103690009267	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3452
103690009268	PAS domain S-box; Region: sensory_box; TIGR00229
103690009269	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009270	PAS domain; Region: PAS_9; pfam13426
103690009271	putative active site [active]
103690009272	heme pocket [chemical binding]; other site
103690009273	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009274	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690009275	putative active site [active]
103690009276	heme pocket [chemical binding]; other site
103690009277	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009278	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690009279	putative active site [active]
103690009280	heme pocket [chemical binding]; other site
103690009281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009282	heme pocket [chemical binding]; other site
103690009283	putative active site [active]
103690009284	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690009285	GAF domain; Region: GAF; pfam01590
103690009286	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690009287	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009288	dimer interface [polypeptide binding]; other site
103690009289	phosphorylation site [posttranslational modification]
103690009290	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009291	ATP binding site [chemical binding]; other site
103690009292	Mg2+ binding site [ion binding]; other site
103690009293	G-X-G motif; other site
103690009294	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009296	active site
103690009297	phosphorylation site [posttranslational modification]
103690009298	intermolecular recognition site; other site
103690009299	dimerization interface [polypeptide binding]; other site
103690009300	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009302	active site
103690009303	phosphorylation site [posttranslational modification]
103690009304	intermolecular recognition site; other site
103690009305	dimerization interface [polypeptide binding]; other site
103690009306	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690009307	putative binding surface; other site
103690009308	active site
103690009309	Uncharacterized conserved protein [Function unknown]; Region: COG0397
103690009310	hypothetical protein; Validated; Region: PRK00029
103690009311	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
103690009312	NMT1-like family; Region: NMT1_2; pfam13379
103690009313	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
103690009314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690009315	dimer interface [polypeptide binding]; other site
103690009316	conserved gate region; other site
103690009317	ABC-ATPase subunit interface; other site
103690009318	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690009319	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
103690009320	Walker A/P-loop; other site
103690009321	ATP binding site [chemical binding]; other site
103690009322	Q-loop/lid; other site
103690009323	ABC transporter signature motif; other site
103690009324	Walker B; other site
103690009325	D-loop; other site
103690009326	H-loop/switch region; other site
103690009327	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
103690009328	NMT1-like family; Region: NMT1_2; pfam13379
103690009329	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690009330	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
103690009331	Walker A/P-loop; other site
103690009332	ATP binding site [chemical binding]; other site
103690009333	Q-loop/lid; other site
103690009334	ABC transporter signature motif; other site
103690009335	Walker B; other site
103690009336	D-loop; other site
103690009337	H-loop/switch region; other site
103690009338	putative lipid kinase; Reviewed; Region: PRK13057
103690009339	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
103690009340	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
103690009341	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690009342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009343	dimer interface [polypeptide binding]; other site
103690009344	phosphorylation site [posttranslational modification]
103690009345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009346	ATP binding site [chemical binding]; other site
103690009347	Mg2+ binding site [ion binding]; other site
103690009348	G-X-G motif; other site
103690009349	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009351	active site
103690009352	phosphorylation site [posttranslational modification]
103690009353	intermolecular recognition site; other site
103690009354	dimerization interface [polypeptide binding]; other site
103690009355	KaiA domain; Region: KaiA; pfam07688
103690009356	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
103690009357	tetramer interface [polypeptide binding]; other site
103690009358	dimer interface [polypeptide binding]; other site
103690009359	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
103690009360	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
103690009361	Walker A motif; other site
103690009362	ATP binding site [chemical binding]; other site
103690009363	Walker B motif; other site
103690009364	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
103690009365	ATP binding site [chemical binding]; other site
103690009366	Walker B motif; other site
103690009367	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
103690009368	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
103690009369	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
103690009370	RNA binding surface [nucleotide binding]; other site
103690009371	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
103690009372	classical (c) SDRs; Region: SDR_c; cd05233
103690009373	NAD(P) binding site [chemical binding]; other site
103690009374	active site
103690009375	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
103690009376	TPR repeat; Region: TPR_11; pfam13414
103690009377	TPR repeat; Region: TPR_11; pfam13414
103690009378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009379	binding surface
103690009380	TPR motif; other site
103690009381	TPR repeat; Region: TPR_11; pfam13414
103690009382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009383	binding surface
103690009384	TPR motif; other site
103690009385	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
103690009386	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690009387	Walker A motif; other site
103690009388	ATP binding site [chemical binding]; other site
103690009389	Walker B motif; other site
103690009390	arginine finger; other site
103690009391	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
103690009392	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
103690009393	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
103690009394	substrate binding site [chemical binding]; other site
103690009395	glutamase interaction surface [polypeptide binding]; other site
103690009396	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009397	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009398	active site
103690009399	phosphorylation site [posttranslational modification]
103690009400	intermolecular recognition site; other site
103690009401	dimerization interface [polypeptide binding]; other site
103690009402	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009403	PAS fold; Region: PAS_3; pfam08447
103690009404	putative active site [active]
103690009405	heme pocket [chemical binding]; other site
103690009406	PAS fold; Region: PAS_3; pfam08447
103690009407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009408	putative active site [active]
103690009409	heme pocket [chemical binding]; other site
103690009410	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690009411	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009412	dimer interface [polypeptide binding]; other site
103690009413	phosphorylation site [posttranslational modification]
103690009414	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009415	ATP binding site [chemical binding]; other site
103690009416	Mg2+ binding site [ion binding]; other site
103690009417	G-X-G motif; other site
103690009418	Response regulator receiver domain; Region: Response_reg; pfam00072
103690009419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009420	active site
103690009421	phosphorylation site [posttranslational modification]
103690009422	intermolecular recognition site; other site
103690009423	dimerization interface [polypeptide binding]; other site
103690009424	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
103690009425	GAF domain; Region: GAF; pfam01590
103690009426	Phytochrome region; Region: PHY; pfam00360
103690009427	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009428	dimer interface [polypeptide binding]; other site
103690009429	phosphorylation site [posttranslational modification]
103690009430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009431	ATP binding site [chemical binding]; other site
103690009432	Mg2+ binding site [ion binding]; other site
103690009433	G-X-G motif; other site
103690009434	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
103690009435	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
103690009436	NADH(P)-binding; Region: NAD_binding_10; pfam13460
103690009437	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
103690009438	NAD(P) binding site [chemical binding]; other site
103690009439	putative active site [active]
103690009440	D-galactonate transporter; Region: 2A0114; TIGR00893
103690009441	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690009442	putative active site [active]
103690009443	hypothetical protein; Validated; Region: PRK07411
103690009444	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
103690009445	ATP binding site [chemical binding]; other site
103690009446	substrate interface [chemical binding]; other site
103690009447	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
103690009448	active site residue [active]
103690009449	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
103690009450	MPN+ (JAMM) motif; other site
103690009451	Zinc-binding site [ion binding]; other site
103690009452	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
103690009453	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690009454	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690009455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337
103690009456	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
103690009457	active site clefts [active]
103690009458	zinc binding site [ion binding]; other site
103690009459	dimer interface [polypeptide binding]; other site
103690009460	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690009461	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
103690009462	Ion channel; Region: Ion_trans_2; pfam07885
103690009463	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690009464	membrane-bound complex binding site; other site
103690009465	hinge residues; other site
103690009466	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
103690009467	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
103690009468	Walker A/P-loop; other site
103690009469	ATP binding site [chemical binding]; other site
103690009470	Q-loop/lid; other site
103690009471	ABC transporter signature motif; other site
103690009472	Walker B; other site
103690009473	D-loop; other site
103690009474	H-loop/switch region; other site
103690009475	Ferredoxin [Energy production and conversion]; Region: COG1146
103690009476	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
103690009477	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
103690009478	dimer interface [polypeptide binding]; other site
103690009479	motif 1; other site
103690009480	active site
103690009481	motif 2; other site
103690009482	motif 3; other site
103690009483	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
103690009484	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690009485	HSP70 interaction site [polypeptide binding]; other site
103690009486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009487	binding surface
103690009488	TPR motif; other site
103690009489	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
103690009490	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
103690009491	active site
103690009492	dimerization interface [polypeptide binding]; other site
103690009493	Staphylococcal nuclease homologues; Region: SNc; smart00318
103690009494	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
103690009495	Catalytic site; other site
103690009496	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690009497	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690009498	catalytic loop [active]
103690009499	iron binding site [ion binding]; other site
103690009500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690009501	active site
103690009502	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
103690009503	active site
103690009504	dinuclear metal binding site [ion binding]; other site
103690009505	dimerization interface [polypeptide binding]; other site
103690009506	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690009507	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
103690009508	active site
103690009509	metal binding site [ion binding]; metal-binding site
103690009510	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
103690009511	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690009512	non-specific DNA binding site [nucleotide binding]; other site
103690009513	salt bridge; other site
103690009514	sequence-specific DNA binding site [nucleotide binding]; other site
103690009515	Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549
103690009516	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690009517	Coenzyme A binding pocket [chemical binding]; other site
103690009518	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
103690009519	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690009520	active site
103690009521	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690009522	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690009523	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690009524	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
103690009525	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
103690009526	active site
103690009527	zinc binding site [ion binding]; other site
103690009528	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690009529	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690009530	ligand binding site [chemical binding]; other site
103690009531	flexible hinge region; other site
103690009532	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690009533	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
103690009534	active site
103690009535	metal binding site [ion binding]; metal-binding site
103690009536	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
103690009537	MltA specific insert domain; Region: MltA; pfam03562
103690009538	3D domain; Region: 3D; pfam06725
103690009539	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
103690009540	glutaminase A; Region: Gln_ase; TIGR03814
103690009541	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
103690009542	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
103690009543	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
103690009544	Pantoate-beta-alanine ligase; Region: PanC; cd00560
103690009545	active site
103690009546	ATP-binding site [chemical binding]; other site
103690009547	pantoate-binding site; other site
103690009548	HXXH motif; other site
103690009549	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
103690009550	CMP-binding site; other site
103690009551	The sites determining sugar specificity; other site
103690009552	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
103690009553	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
103690009554	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
103690009555	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
103690009556	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
103690009557	active site
103690009558	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690009559	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690009560	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690009561	Uncharacterized conserved protein [Function unknown]; Region: COG3391
103690009562	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
103690009563	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
103690009564	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
103690009565	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
103690009566	bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108
103690009567	Moco binding site; other site
103690009568	metal coordination site [ion binding]; other site
103690009569	bifunctional orotidine 5'-phosphate decarboxylase/orotate phosphoribosyltransferase protein; Validated; Region: PRK05500
103690009570	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
103690009571	active site
103690009572	dimer interface [polypeptide binding]; other site
103690009573	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690009574	active site
103690009575	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690009576	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690009577	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
103690009578	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
103690009579	putative NAD(P) binding site [chemical binding]; other site
103690009580	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
103690009581	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
103690009582	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
103690009583	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
103690009584	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
103690009585	Protein of unknown function (DUF790); Region: DUF790; pfam05626
103690009586	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
103690009587	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690009588	ATP binding site [chemical binding]; other site
103690009589	putative Mg++ binding site [ion binding]; other site
103690009590	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690009591	nucleotide binding region [chemical binding]; other site
103690009592	ATP-binding site [chemical binding]; other site
103690009593	Transglycosylase; Region: Transgly; pfam00912
103690009594	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
103690009595	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690009596	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Coenzyme metabolism]; Region: FolK; COG0801
103690009597	catalytic center binding site [active]
103690009598	ATP binding site [chemical binding]; other site
103690009599	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
103690009600	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
103690009601	dimer interface [polypeptide binding]; other site
103690009602	ADP-ribose binding site [chemical binding]; other site
103690009603	active site
103690009604	nudix motif; other site
103690009605	metal binding site [ion binding]; metal-binding site
103690009606	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690009607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690009608	active site
103690009609	phosphorylation site [posttranslational modification]
103690009610	intermolecular recognition site; other site
103690009611	dimerization interface [polypeptide binding]; other site
103690009612	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
103690009613	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009614	dimer interface [polypeptide binding]; other site
103690009615	phosphorylation site [posttranslational modification]
103690009616	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690009617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009618	ATP binding site [chemical binding]; other site
103690009619	Mg2+ binding site [ion binding]; other site
103690009620	G-X-G motif; other site
103690009621	Uncharacterized conserved protein [Function unknown]; Region: COG0062
103690009622	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
103690009623	putative substrate binding site [chemical binding]; other site
103690009624	putative ATP binding site [chemical binding]; other site
103690009625	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690009626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
103690009627	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
103690009628	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
103690009629	putative active site [active]
103690009630	putative NTP binding site [chemical binding]; other site
103690009631	putative nucleic acid binding site [nucleotide binding]; other site
103690009632	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690009633	non-specific DNA binding site [nucleotide binding]; other site
103690009634	salt bridge; other site
103690009635	sequence-specific DNA binding site [nucleotide binding]; other site
103690009636	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
103690009637	classical (c) SDRs; Region: SDR_c; cd05233
103690009638	NAD(P) binding site [chemical binding]; other site
103690009639	active site
103690009640	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690009641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690009642	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690009643	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
103690009644	DNA photolyase; Region: DNA_photolyase; pfam00875
103690009645	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
103690009646	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
103690009647	active site
103690009648	catalytic residues [active]
103690009649	metal binding site [ion binding]; metal-binding site
103690009650	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
103690009651	L-aspartate oxidase; Provisional; Region: PRK06175
103690009652	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
103690009653	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
103690009654	catalytic core [active]
103690009655	glucokinase; Provisional; Region: glk; PRK00292
103690009656	glucokinase, proteobacterial type; Region: glk; TIGR00749
103690009657	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
103690009658	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
103690009659	Catalytic site [active]
103690009660	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
103690009661	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
103690009662	Short C-terminal domain; Region: SHOCT; pfam09851
103690009663	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
103690009664	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690009665	HSP70 interaction site [polypeptide binding]; other site
103690009666	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009667	binding surface
103690009668	TPR motif; other site
103690009669	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
103690009670	Transglycosylase; Region: Transgly; pfam00912
103690009671	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
103690009672	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690009673	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
103690009674	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
103690009675	active site
103690009676	HIGH motif; other site
103690009677	dimer interface [polypeptide binding]; other site
103690009678	KMSKS motif; other site
103690009679	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
103690009680	active site
103690009681	dimer interface [polypeptide binding]; other site
103690009682	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
103690009683	HEAT repeats; Region: HEAT_2; pfam13646
103690009684	protein binding surface [polypeptide binding]; other site
103690009685	HEAT repeats; Region: HEAT_2; pfam13646
103690009686	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690009687	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690009688	HEAT repeats; Region: HEAT_2; pfam13646
103690009689	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690009690	NACHT domain; Region: NACHT; pfam05729
103690009691	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690009692	Predicted membrane protein [Function unknown]; Region: COG3781
103690009693	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690009694	putative active site [active]
103690009695	M28 Zn-Peptidases; Region: M28_like_1; cd05640
103690009696	Peptidase family M28; Region: Peptidase_M28; pfam04389
103690009697	metal binding site [ion binding]; metal-binding site
103690009698	molecular chaperone DnaK; Provisional; Region: PRK13410
103690009699	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
103690009700	nucleotide binding site [chemical binding]; other site
103690009701	NEF interaction site [polypeptide binding]; other site
103690009702	SBD interface [polypeptide binding]; other site
103690009703	chaperone protein DnaJ; Provisional; Region: PRK14277
103690009704	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690009705	HSP70 interaction site [polypeptide binding]; other site
103690009706	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
103690009707	substrate binding site [polypeptide binding]; other site
103690009708	dimer interface [polypeptide binding]; other site
103690009709	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690009710	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690009711	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
103690009712	HSP70 interaction site [polypeptide binding]; other site
103690009713	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
103690009714	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
103690009715	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
103690009716	catalytic residue [active]
103690009717	putative FPP diphosphate  binding site; other site
103690009718	putative FPP binding hydrophobic cleft; other site
103690009719	dimer interface [polypeptide binding]; other site
103690009720	putative IPP diphosphate binding site; other site
103690009721	Uncharacterized conserved protein [Function unknown]; Region: COG1624
103690009722	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
103690009723	diaminopimelate decarboxylase; Region: lysA; TIGR01048
103690009724	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
103690009725	active site
103690009726	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
103690009727	substrate binding site [chemical binding]; other site
103690009728	catalytic residues [active]
103690009729	dimer interface [polypeptide binding]; other site
103690009730	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
103690009731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690009732	Coenzyme A binding pocket [chemical binding]; other site
103690009733	Clp protease ATP binding subunit; Region: clpC; CHL00095
103690009734	Clp amino terminal domain; Region: Clp_N; pfam02861
103690009735	Clp amino terminal domain; Region: Clp_N; pfam02861
103690009736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690009737	Walker A motif; other site
103690009738	ATP binding site [chemical binding]; other site
103690009739	Walker B motif; other site
103690009740	arginine finger; other site
103690009741	UvrB/uvrC motif; Region: UVR; pfam02151
103690009742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690009743	Walker A motif; other site
103690009744	ATP binding site [chemical binding]; other site
103690009745	Walker B motif; other site
103690009746	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
103690009747	Uncharacterized conserved protein [Function unknown]; Region: COG4748
103690009748	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
103690009749	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690009750	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550
103690009751	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
103690009752	PemK-like protein; Region: PemK; pfam02452
103690009753	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
103690009754	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
103690009755	dimerization interface [polypeptide binding]; other site
103690009756	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009758	binding surface
103690009759	TPR motif; other site
103690009760	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009761	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690009762	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009763	TPR motif; other site
103690009764	binding surface
103690009765	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
103690009766	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
103690009767	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
103690009768	inhibitor-cofactor binding pocket; inhibition site
103690009769	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690009770	catalytic residue [active]
103690009771	Protein of unknown function (DUF561); Region: DUF561; pfam04481
103690009772	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
103690009773	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690009774	active site
103690009775	metal binding site [ion binding]; metal-binding site
103690009776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690009777	S-adenosylmethionine binding site [chemical binding]; other site
103690009778	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009779	TPR motif; other site
103690009780	binding surface
103690009781	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009782	binding surface
103690009783	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009784	TPR motif; other site
103690009785	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009786	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009787	binding surface
103690009788	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009789	TPR motif; other site
103690009790	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690009791	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
103690009792	Fe-S cluster binding site [ion binding]; other site
103690009793	active site
103690009794	Predicted membrane protein [Function unknown]; Region: COG1808
103690009795	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690009796	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690009797	HPP family; Region: HPP; pfam04982
103690009798	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
103690009799	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
103690009800	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
103690009801	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690009802	Coenzyme A binding pocket [chemical binding]; other site
103690009803	TRAP-type mannitol/chloroaromatic compound transport system, small permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT2; COG4665
103690009804	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
103690009805	DctM-like transporters; Region: DctM; pfam06808
103690009806	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
103690009807	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
103690009808	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
103690009809	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
103690009810	Rab subfamily motif 1 (RabSF1); other site
103690009811	G1 box; other site
103690009812	GTP/Mg2+ binding site [chemical binding]; other site
103690009813	Rab subfamily motif 2 (RabSF2); other site
103690009814	Switch I region; other site
103690009815	G2 box; other site
103690009816	effector interaction site; other site
103690009817	GDI interaction site; other site
103690009818	Rab family motif 1 (RabF1); other site
103690009819	GEF interaction site [polypeptide binding]; other site
103690009820	Rab family motif 2 (RabF2); other site
103690009821	G3 box; other site
103690009822	Switch II region; other site
103690009823	Rab family motif 3 (RabF3); other site
103690009824	Rab family motif 4 (RabF4); other site
103690009825	Rab family motif 5 (RabF5); other site
103690009826	Rab subfamily motif 3 (RabSF3); other site
103690009827	G4 box; other site
103690009828	G5 box; other site
103690009829	Rab subfamily motif 4 (RabSF4); other site
103690009830	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
103690009831	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
103690009832	ligand binding site [chemical binding]; other site
103690009833	Glucosidase II beta subunit-like; Region: PRKCSH-like; pfam12999
103690009834	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
103690009835	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
103690009836	transmembrane helices; other site
103690009837	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
103690009838	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690009839	Walker A/P-loop; other site
103690009840	ATP binding site [chemical binding]; other site
103690009841	Q-loop/lid; other site
103690009842	ABC transporter signature motif; other site
103690009843	Walker B; other site
103690009844	D-loop; other site
103690009845	H-loop/switch region; other site
103690009846	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
103690009847	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690009848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690009849	dimer interface [polypeptide binding]; other site
103690009850	phosphorylation site [posttranslational modification]
103690009851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009852	ATP binding site [chemical binding]; other site
103690009853	Mg2+ binding site [ion binding]; other site
103690009854	G-X-G motif; other site
103690009855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690009856	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690009857	S-adenosylmethionine binding site [chemical binding]; other site
103690009858	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
103690009859	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
103690009860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690009861	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
103690009862	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
103690009863	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
103690009864	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
103690009865	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
103690009866	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690009867	Methyltransferase domain; Region: Methyltransf_24; pfam13578
103690009868	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690009869	HSP70 interaction site [polypeptide binding]; other site
103690009870	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690009871	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690009872	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690009873	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690009874	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398
103690009875	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
103690009876	Predicted membrane protein [Function unknown]; Region: COG2259
103690009877	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
103690009878	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
103690009879	dimerization interface [polypeptide binding]; other site
103690009880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
103690009881	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
103690009882	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
103690009883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690009884	ATP binding site [chemical binding]; other site
103690009885	Mg2+ binding site [ion binding]; other site
103690009886	G-X-G motif; other site
103690009887	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
103690009888	ATP binding site [chemical binding]; other site
103690009889	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
103690009890	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
103690009891	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
103690009892	NAD binding site [chemical binding]; other site
103690009893	dimerization interface [polypeptide binding]; other site
103690009894	product binding site; other site
103690009895	substrate binding site [chemical binding]; other site
103690009896	zinc binding site [ion binding]; other site
103690009897	catalytic residues [active]
103690009898	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690009899	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009900	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009901	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
103690009902	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690009903	Chain length determinant protein; Region: Wzz; pfam02706
103690009904	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
103690009905	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690009906	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690009907	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
103690009908	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
103690009909	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
103690009910	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009911	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009912	active site
103690009913	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009914	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009915	active site
103690009916	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690009917	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009918	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
103690009919	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
103690009920	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
103690009921	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
103690009922	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690009923	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009924	active site
103690009925	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690009926	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009927	active site
103690009928	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690009929	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690009930	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
103690009931	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009932	active site
103690009933	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009934	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009935	active site
103690009936	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
103690009937	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690009938	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690009939	active site
103690009940	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
103690009941	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
103690009942	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
103690009943	trimer interface [polypeptide binding]; other site
103690009944	active site
103690009945	UDP-GlcNAc binding site [chemical binding]; other site
103690009946	lipid binding site [chemical binding]; lipid-binding site
103690009947	Maf-like protein; Region: Maf; pfam02545
103690009948	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
103690009949	active site
103690009950	dimer interface [polypeptide binding]; other site
103690009951	PsbP; Region: PsbP; pfam01789
103690009952	Uncharacterized conserved protein [Function unknown]; Region: COG5634
103690009953	Lamin Tail Domain; Region: LTD; pfam00932
103690009954	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
103690009955	active site
103690009956	catalytic residues [active]
103690009957	metal binding site [ion binding]; metal-binding site
103690009958	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690009959	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690009960	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009961	binding surface
103690009962	TPR repeat; Region: TPR_11; pfam13414
103690009963	TPR motif; other site
103690009964	TPR repeat; Region: TPR_11; pfam13414
103690009965	TPR repeat; Region: TPR_11; pfam13414
103690009966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690009967	binding surface
103690009968	TPR motif; other site
103690009969	TPR repeat; Region: TPR_11; pfam13414
103690009970	TPR repeat; Region: TPR_11; pfam13414
103690009971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4340
103690009972	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
103690009973	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
103690009974	ATP-binding site [chemical binding]; other site
103690009975	Gluconate-6-phosphate binding site [chemical binding]; other site
103690009976	Shikimate kinase; Region: SKI; pfam01202
103690009977	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
103690009978	PLD-like domain; Region: PLDc_2; pfam13091
103690009979	putative active site [active]
103690009980	catalytic site [active]
103690009981	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
103690009982	PLD-like domain; Region: PLDc_2; pfam13091
103690009983	putative active site [active]
103690009984	catalytic site [active]
103690009985	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
103690009986	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
103690009987	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
103690009988	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690009989	catalytic residue [active]
103690009990	Predicted membrane protein [Function unknown]; Region: COG2261
103690009991	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
103690009992	Ferritin-like domain; Region: Ferritin; pfam00210
103690009993	dimanganese center [ion binding]; other site
103690009994	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
103690009995	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
103690009996	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690009997	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690009998	putative active site [active]
103690009999	heme pocket [chemical binding]; other site
103690010000	PAS fold; Region: PAS_4; pfam08448
103690010001	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010002	PAS fold; Region: PAS_3; pfam08447
103690010003	putative active site [active]
103690010004	heme pocket [chemical binding]; other site
103690010005	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010006	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690010007	putative active site [active]
103690010008	heme pocket [chemical binding]; other site
103690010009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010010	putative active site [active]
103690010011	heme pocket [chemical binding]; other site
103690010012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690010013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010014	dimer interface [polypeptide binding]; other site
103690010015	phosphorylation site [posttranslational modification]
103690010016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010017	ATP binding site [chemical binding]; other site
103690010018	Mg2+ binding site [ion binding]; other site
103690010019	G-X-G motif; other site
103690010020	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690010021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010022	active site
103690010023	phosphorylation site [posttranslational modification]
103690010024	intermolecular recognition site; other site
103690010025	dimerization interface [polypeptide binding]; other site
103690010026	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
103690010027	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
103690010028	purine monophosphate binding site [chemical binding]; other site
103690010029	dimer interface [polypeptide binding]; other site
103690010030	putative catalytic residues [active]
103690010031	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
103690010032	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
103690010033	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690010034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690010035	S-adenosylmethionine binding site [chemical binding]; other site
103690010036	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
103690010037	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
103690010038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690010039	FeS/SAM binding site; other site
103690010040	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
103690010041	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
103690010042	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690010043	Coenzyme A binding pocket [chemical binding]; other site
103690010044	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
103690010045	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
103690010046	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
103690010047	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
103690010048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690010049	gamma-glutamyl kinase; Provisional; Region: PRK05429
103690010050	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
103690010051	nucleotide binding site [chemical binding]; other site
103690010052	homotetrameric interface [polypeptide binding]; other site
103690010053	putative phosphate binding site [ion binding]; other site
103690010054	putative allosteric binding site; other site
103690010055	PUA domain; Region: PUA; pfam01472
103690010056	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
103690010057	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
103690010058	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690010059	active site
103690010060	catalytic residues [active]
103690010061	DNA binding site [nucleotide binding]
103690010062	Int/Topo IB signature motif; other site
103690010063	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690010064	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690010065	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
103690010066	Flavoprotein; Region: Flavoprotein; pfam02441
103690010067	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
103690010068	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
103690010069	Predicted esterase [General function prediction only]; Region: COG0400
103690010070	putative hydrolase; Provisional; Region: PRK11460
103690010071	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690010072	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010075	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010076	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010077	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010078	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
103690010079	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
103690010080	active site
103690010081	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
103690010082	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690010083	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690010084	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690010085	active site
103690010086	ATP binding site [chemical binding]; other site
103690010087	substrate binding site [chemical binding]; other site
103690010088	activation loop (A-loop); other site
103690010089	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690010090	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690010091	structural tetrad; other site
103690010092	FOG: CBS domain [General function prediction only]; Region: COG0517
103690010093	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
103690010094	FOG: CBS domain [General function prediction only]; Region: COG0517
103690010095	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
103690010096	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690010097	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690010098	PAS fold; Region: PAS_3; pfam08447
103690010099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010100	heme pocket [chemical binding]; other site
103690010101	putative active site [active]
103690010102	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690010103	GAF domain; Region: GAF; pfam01590
103690010104	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690010105	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010106	dimer interface [polypeptide binding]; other site
103690010107	phosphorylation site [posttranslational modification]
103690010108	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010109	ATP binding site [chemical binding]; other site
103690010110	Mg2+ binding site [ion binding]; other site
103690010111	G-X-G motif; other site
103690010112	Response regulator receiver domain; Region: Response_reg; pfam00072
103690010113	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010114	active site
103690010115	phosphorylation site [posttranslational modification]
103690010116	intermolecular recognition site; other site
103690010117	dimerization interface [polypeptide binding]; other site
103690010118	Response regulator receiver domain; Region: Response_reg; pfam00072
103690010119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010120	active site
103690010121	phosphorylation site [posttranslational modification]
103690010122	intermolecular recognition site; other site
103690010123	dimerization interface [polypeptide binding]; other site
103690010124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690010125	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010126	dimer interface [polypeptide binding]; other site
103690010127	phosphorylation site [posttranslational modification]
103690010128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010129	ATP binding site [chemical binding]; other site
103690010130	Mg2+ binding site [ion binding]; other site
103690010131	G-X-G motif; other site
103690010132	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
103690010133	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
103690010134	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
103690010135	ResB-like family; Region: ResB; pfam05140
103690010136	XisI protein; Region: XisI; pfam08869
103690010137	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
103690010138	heme binding pocket [chemical binding]; other site
103690010139	heme ligand [chemical binding]; other site
103690010140	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
103690010141	HemN C-terminal domain; Region: HemN_C; pfam06969
103690010142	Uncharacterized conserved protein [Function unknown]; Region: COG4278
103690010143	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
103690010144	putative active site [active]
103690010145	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
103690010146	putative acetyltransferase; Provisional; Region: PRK03624
103690010147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690010148	Coenzyme A binding pocket [chemical binding]; other site
103690010149	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
103690010150	Predicted ATPase [General function prediction only]; Region: COG4637
103690010151	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690010152	Walker A/P-loop; other site
103690010153	ATP binding site [chemical binding]; other site
103690010154	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
103690010155	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
103690010156	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
103690010157	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
103690010158	active site
103690010159	NTP binding site [chemical binding]; other site
103690010160	metal binding triad [ion binding]; metal-binding site
103690010161	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
103690010162	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
103690010163	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
103690010164	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
103690010165	Glycoprotease family; Region: Peptidase_M22; pfam00814
103690010166	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
103690010167	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
103690010168	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690010169	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690010170	Walker A motif; other site
103690010171	ATP binding site [chemical binding]; other site
103690010172	Walker B motif; other site
103690010173	arginine finger; other site
103690010174	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
103690010175	Protein export membrane protein; Region: SecD_SecF; cl14618
103690010176	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690010177	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690010178	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690010179	phosphoenolpyruvate synthase; Validated; Region: PRK06464
103690010180	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
103690010181	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
103690010182	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
103690010183	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
103690010184	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690010185	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
103690010186	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
103690010187	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
103690010188	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
103690010189	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
103690010190	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690010191	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690010192	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
103690010193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690010194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010195	dimer interface [polypeptide binding]; other site
103690010196	phosphorylation site [posttranslational modification]
103690010197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010198	ATP binding site [chemical binding]; other site
103690010199	Mg2+ binding site [ion binding]; other site
103690010200	G-X-G motif; other site
103690010201	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690010202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010203	active site
103690010204	phosphorylation site [posttranslational modification]
103690010205	intermolecular recognition site; other site
103690010206	dimerization interface [polypeptide binding]; other site
103690010207	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690010208	DNA binding residues [nucleotide binding]
103690010209	dimerization interface [polypeptide binding]; other site
103690010210	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
103690010211	GAF domain; Region: GAF; pfam01590
103690010212	Phytochrome region; Region: PHY; pfam00360
103690010213	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010214	dimer interface [polypeptide binding]; other site
103690010215	phosphorylation site [posttranslational modification]
103690010216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010217	ATP binding site [chemical binding]; other site
103690010218	Mg2+ binding site [ion binding]; other site
103690010219	G-X-G motif; other site
103690010220	Response regulator receiver domain; Region: Response_reg; pfam00072
103690010221	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010222	active site
103690010223	phosphorylation site [posttranslational modification]
103690010224	intermolecular recognition site; other site
103690010225	dimerization interface [polypeptide binding]; other site
103690010226	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690010227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010228	active site
103690010229	phosphorylation site [posttranslational modification]
103690010230	intermolecular recognition site; other site
103690010231	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690010232	dimerization interface [polypeptide binding]; other site
103690010233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010234	dimer interface [polypeptide binding]; other site
103690010235	phosphorylation site [posttranslational modification]
103690010236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010237	ATP binding site [chemical binding]; other site
103690010238	Mg2+ binding site [ion binding]; other site
103690010239	G-X-G motif; other site
103690010240	topology modulation protein; Reviewed; Region: PRK08118
103690010241	AAA domain; Region: AAA_17; pfam13207
103690010242	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
103690010243	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690010244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690010245	motif II; other site
103690010246	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
103690010247	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
103690010248	DNA binding residues [nucleotide binding]
103690010249	dimer interface [polypeptide binding]; other site
103690010250	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; COG2082
103690010251	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
103690010252	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690010253	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690010254	Bacteriorhodopsin [General function prediction only]; Region: COG5524
103690010255	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
103690010256	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
103690010257	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010258	dimer interface [polypeptide binding]; other site
103690010259	phosphorylation site [posttranslational modification]
103690010260	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010261	ATP binding site [chemical binding]; other site
103690010262	Mg2+ binding site [ion binding]; other site
103690010263	G-X-G motif; other site
103690010264	hypothetical protein; Provisional; Region: PRK02724
103690010265	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690010266	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690010267	active site
103690010268	ATP binding site [chemical binding]; other site
103690010269	substrate binding site [chemical binding]; other site
103690010270	activation loop (A-loop); other site
103690010271	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690010272	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690010273	structural tetrad; other site
103690010274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010275	cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359
103690010276	putative active site [active]
103690010277	heme pocket [chemical binding]; other site
103690010278	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010279	putative active site [active]
103690010280	heme pocket [chemical binding]; other site
103690010281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010282	putative active site [active]
103690010283	heme pocket [chemical binding]; other site
103690010284	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690010285	metal binding site [ion binding]; metal-binding site
103690010286	active site
103690010287	I-site; other site
103690010288	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690010289	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690010290	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690010291	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690010292	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
103690010293	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
103690010294	homotrimer interface [polypeptide binding]; other site
103690010295	Walker A motif; other site
103690010296	GTP binding site [chemical binding]; other site
103690010297	Walker B motif; other site
103690010298	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690010299	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690010300	active site
103690010301	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
103690010302	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690010303	putative metal binding site; other site
103690010304	putative acyl transferase; Provisional; Region: PRK10502
103690010305	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
103690010306	putative trimer interface [polypeptide binding]; other site
103690010307	putative active site [active]
103690010308	putative substrate binding site [chemical binding]; other site
103690010309	putative CoA binding site [chemical binding]; other site
103690010310	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690010311	CHAT domain; Region: CHAT; cl17868
103690010312	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690010313	CHASE2 domain; Region: CHASE2; pfam05226
103690010314	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690010315	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
103690010316	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
103690010317	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
103690010318	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690010319	catalytic triad [active]
103690010320	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
103690010321	30S subunit binding site; other site
103690010322	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
103690010323	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690010324	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
103690010325	substrate binding pocket [chemical binding]; other site
103690010326	membrane-bound complex binding site; other site
103690010327	hinge residues; other site
103690010328	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
103690010329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690010330	dimer interface [polypeptide binding]; other site
103690010331	conserved gate region; other site
103690010332	putative PBP binding loops; other site
103690010333	ABC-ATPase subunit interface; other site
103690010334	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
103690010335	Beta-carotene ketolase/oxygenase (CrtW, also known as CrtO), the carotenoid astaxanthin biosynthetic enzyme, initially catalyzes the addition of two keto groups to carbons C4 and C4' of beta-carotene. Carotenoids are important natural pigments...; Region: CrtW_beta-carotene-ketolase; cd03513
103690010336	Fatty acid desaturase; Region: FA_desaturase; pfam00487
103690010337	putative di-iron ligands [ion binding]; other site
103690010338	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
103690010339	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
103690010340	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
103690010341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690010342	binding surface
103690010343	TPR motif; other site
103690010344	Uncharacterized conserved protein [Function unknown]; Region: COG2135
103690010345	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690010346	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
103690010347	putative C-terminal domain interface [polypeptide binding]; other site
103690010348	putative GSH binding site (G-site) [chemical binding]; other site
103690010349	putative dimer interface [polypeptide binding]; other site
103690010350	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
103690010351	N-terminal domain interface [polypeptide binding]; other site
103690010352	dimer interface [polypeptide binding]; other site
103690010353	substrate binding pocket (H-site) [chemical binding]; other site
103690010354	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
103690010355	Predicted membrane protein [Function unknown]; Region: COG4244
103690010356	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
103690010357	Hemerythrin-like domain; Region: Hr-like; cd12108
103690010358	Fe binding site [ion binding]; other site
103690010359	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690010360	putative active site [active]
103690010361	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
103690010362	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690010363	S-adenosylmethionine binding site [chemical binding]; other site
103690010364	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
103690010365	nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans.  Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649
103690010366	active site
103690010367	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
103690010368	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
103690010369	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
103690010370	HIGH motif; other site
103690010371	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
103690010372	active site
103690010373	KMSKS motif; other site
103690010374	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
103690010375	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690010376	active site
103690010377	ATP binding site [chemical binding]; other site
103690010378	substrate binding site [chemical binding]; other site
103690010379	activation loop (A-loop); other site
103690010380	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690010381	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690010382	active site
103690010383	ATP binding site [chemical binding]; other site
103690010384	substrate binding site [chemical binding]; other site
103690010385	activation loop (A-loop); other site
103690010386	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
103690010387	SdiA-regulated; Region: SdiA-regulated; cd09971
103690010388	putative active site [active]
103690010389	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
103690010390	RNase_H superfamily; Region: RNase_H_2; pfam13482
103690010391	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
103690010392	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
103690010393	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690010394	catalytic residue [active]
103690010395	PemK-like protein; Region: PemK; cl00995
103690010396	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
103690010397	conserved hypothetical protein; Region: MJ1255; TIGR00661
103690010398	Uncharacterized conserved protein [Function unknown]; Region: COG0432
103690010399	NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14350
103690010400	Uncharacterized conserved protein [Function unknown]; Region: COG0327
103690010401	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
103690010402	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
103690010403	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690010404	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690010405	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690010406	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690010407	P-loop; other site
103690010408	Magnesium ion binding site [ion binding]; other site
103690010409	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
103690010410	Sporulation and spore germination; Region: Germane; cl11253
103690010411	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690010412	active site
103690010413	catalytic residues [active]
103690010414	DNA binding site [nucleotide binding]
103690010415	Int/Topo IB signature motif; other site
103690010416	PAS fold; Region: PAS_4; pfam08448
103690010417	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010418	PAS fold; Region: PAS_3; pfam08447
103690010419	putative active site [active]
103690010420	heme pocket [chemical binding]; other site
103690010421	PAS fold; Region: PAS_4; pfam08448
103690010422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010423	putative active site [active]
103690010424	heme pocket [chemical binding]; other site
103690010425	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010426	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690010427	putative active site [active]
103690010428	heme pocket [chemical binding]; other site
103690010429	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010430	putative active site [active]
103690010431	heme pocket [chemical binding]; other site
103690010432	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010433	dimer interface [polypeptide binding]; other site
103690010434	phosphorylation site [posttranslational modification]
103690010435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010436	ATP binding site [chemical binding]; other site
103690010437	Mg2+ binding site [ion binding]; other site
103690010438	G-X-G motif; other site
103690010439	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690010440	Caspase domain; Region: Peptidase_C14; pfam00656
103690010441	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690010442	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690010443	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
103690010444	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
103690010445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690010446	S-adenosylmethionine binding site [chemical binding]; other site
103690010447	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
103690010448	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
103690010449	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
103690010450	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
103690010451	Response regulator receiver domain; Region: Response_reg; pfam00072
103690010452	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010453	active site
103690010454	phosphorylation site [posttranslational modification]
103690010455	intermolecular recognition site; other site
103690010456	dimerization interface [polypeptide binding]; other site
103690010457	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
103690010458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690010459	anthranilate synthase; Provisional; Region: PRK13566
103690010460	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
103690010461	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
103690010462	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
103690010463	glutamine binding [chemical binding]; other site
103690010464	catalytic triad [active]
103690010465	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
103690010466	active site
103690010467	ribulose/triose binding site [chemical binding]; other site
103690010468	phosphate binding site [ion binding]; other site
103690010469	substrate (anthranilate) binding pocket [chemical binding]; other site
103690010470	product (indole) binding pocket [chemical binding]; other site
103690010471	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690010472	binding surface
103690010473	TPR motif; other site
103690010474	TPR repeat; Region: TPR_11; pfam13414
103690010475	Uncharacterized conserved protein [Function unknown]; Region: COG5609
103690010476	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690010477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010478	active site
103690010479	phosphorylation site [posttranslational modification]
103690010480	intermolecular recognition site; other site
103690010481	dimerization interface [polypeptide binding]; other site
103690010482	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
103690010483	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690010484	ABC-ATPase subunit  interface; other site
103690010485	dimer interface [polypeptide binding]; other site
103690010486	putative PBP binding regions; other site
103690010487	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
103690010488	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
103690010489	Walker A/P-loop; other site
103690010490	ATP binding site [chemical binding]; other site
103690010491	Q-loop/lid; other site
103690010492	ABC transporter signature motif; other site
103690010493	Walker B; other site
103690010494	D-loop; other site
103690010495	H-loop/switch region; other site
103690010496	AMIN domain; Region: AMIN; pfam11741
103690010497	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
103690010498	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690010499	N-terminal plug; other site
103690010500	ligand-binding site [chemical binding]; other site
103690010501	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690010502	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
103690010503	putative ligand binding site [chemical binding]; other site
103690010504	S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192
103690010505	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
103690010506	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
103690010507	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
103690010508	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
103690010509	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690010510	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
103690010511	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
103690010512	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690010513	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
103690010514	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
103690010515	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
103690010516	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
103690010517	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
103690010518	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
103690010519	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
103690010520	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
103690010521	Protein of unknown function (DUF1838); Region: DUF1838; pfam08894
103690010522	short chain dehydrogenase; Provisional; Region: PRK08303
103690010523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690010524	NAD(P) binding site [chemical binding]; other site
103690010525	active site
103690010526	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
103690010527	RNA binding surface [nucleotide binding]; other site
103690010528	Site-specific recombinase; Region: SpecificRecomb; cl15411
103690010529	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
103690010530	Cadmium resistance transporter; Region: Cad; pfam03596
103690010531	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010532	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690010533	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010534	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690010535	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010536	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010537	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
103690010538	putative hexamer interface [polypeptide binding]; other site
103690010539	putative hexagonal pore; other site
103690010540	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
103690010541	Hexamer interface [polypeptide binding]; other site
103690010542	Hexagonal pore residue; other site
103690010543	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690010544	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690010545	motif II; other site
103690010546	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
103690010547	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690010548	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010549	active site
103690010550	phosphorylation site [posttranslational modification]
103690010551	intermolecular recognition site; other site
103690010552	dimerization interface [polypeptide binding]; other site
103690010553	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690010554	DNA binding site [nucleotide binding]
103690010555	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
103690010556	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
103690010557	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
103690010558	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
103690010559	metal binding site [ion binding]; metal-binding site
103690010560	Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572
103690010561	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
103690010562	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
103690010563	inhibitor-cofactor binding pocket; inhibition site
103690010564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690010565	catalytic residue [active]
103690010566	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690010567	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690010568	active site
103690010569	ATP binding site [chemical binding]; other site
103690010570	substrate binding site [chemical binding]; other site
103690010571	activation loop (A-loop); other site
103690010572	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010573	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690010574	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010575	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010576	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690010577	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690010578	phosphopeptide binding site; other site
103690010579	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
103690010580	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
103690010581	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
103690010582	recombinase A; Provisional; Region: recA; PRK09354
103690010583	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
103690010584	hexamer interface [polypeptide binding]; other site
103690010585	Walker A motif; other site
103690010586	ATP binding site [chemical binding]; other site
103690010587	Walker B motif; other site
103690010588	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
103690010589	dimer interface [polypeptide binding]; other site
103690010590	catalytic triad [active]
103690010591	UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210
103690010592	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
103690010593	active site
103690010594	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
103690010595	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690010596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690010597	putative active site [active]
103690010598	heme pocket [chemical binding]; other site
103690010599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690010600	dimer interface [polypeptide binding]; other site
103690010601	phosphorylation site [posttranslational modification]
103690010602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010603	ATP binding site [chemical binding]; other site
103690010604	Mg2+ binding site [ion binding]; other site
103690010605	G-X-G motif; other site
103690010606	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690010607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010608	active site
103690010609	phosphorylation site [posttranslational modification]
103690010610	intermolecular recognition site; other site
103690010611	dimerization interface [polypeptide binding]; other site
103690010612	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690010613	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690010614	Late competence development protein ComFB; Region: ComFB; pfam10719
103690010615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
103690010616	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
103690010617	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
103690010618	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690010619	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690010620	DNA binding residues [nucleotide binding]
103690010621	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
103690010622	Putative zinc-finger; Region: zf-HC2; pfam13490
103690010623	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
103690010624	putative active site pocket [active]
103690010625	dimerization interface [polypeptide binding]; other site
103690010626	putative catalytic residue [active]
103690010627	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
103690010628	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
103690010629	HIGH motif; other site
103690010630	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
103690010631	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
103690010632	active site
103690010633	KMSKS motif; other site
103690010634	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
103690010635	tRNA binding surface [nucleotide binding]; other site
103690010636	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
103690010637	nucleoside/Zn binding site; other site
103690010638	dimer interface [polypeptide binding]; other site
103690010639	catalytic motif [active]
103690010640	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
103690010641	active site
103690010642	dimerization interface [polypeptide binding]; other site
103690010643	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
103690010644	amidase catalytic site [active]
103690010645	Zn binding residues [ion binding]; other site
103690010646	substrate binding site [chemical binding]; other site
103690010647	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
103690010648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
103690010649	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690010650	conserved repeat domain; Region: B_ant_repeat; TIGR01451
103690010651	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
103690010652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
103690010653	threonine synthase; Validated; Region: PRK07591
103690010654	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
103690010655	homodimer interface [polypeptide binding]; other site
103690010656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690010657	catalytic residue [active]
103690010658	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
103690010659	MoaE interaction surface [polypeptide binding]; other site
103690010660	MoeB interaction surface [polypeptide binding]; other site
103690010661	thiocarboxylated glycine; other site
103690010662	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
103690010663	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
103690010664	tetramer interface [polypeptide binding]; other site
103690010665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690010666	catalytic residue [active]
103690010667	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
103690010668	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
103690010669	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
103690010670	diiron binding motif [ion binding]; other site
103690010671	ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187
103690010672	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690010673	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690010674	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010675	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010676	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010677	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010678	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010679	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690010680	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
103690010681	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690010682	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
103690010683	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690010684	N-terminal plug; other site
103690010685	ligand-binding site [chemical binding]; other site
103690010686	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
103690010687	Orientia OTT_1508-like deaminase; Region: OTT_1508_deam; pfam14441
103690010688	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
103690010689	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
103690010690	Phage baseplate assembly protein W [General function prediction only]; Region: COG3628
103690010691	Uncharacterized conserved protein [Function unknown]; Region: COG4104
103690010692	Phage protein D [General function prediction only]; Region: COG3500
103690010693	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
103690010694	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
103690010695	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
103690010696	conserved hypothetical phage tail region protein; Region: TIGR02241
103690010697	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
103690010698	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
103690010699	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
103690010700	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
103690010701	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
103690010702	tetramer interface [polypeptide binding]; other site
103690010703	dimer interface [polypeptide binding]; other site
103690010704	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
103690010705	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
103690010706	Walker A motif; other site
103690010707	ATP binding site [chemical binding]; other site
103690010708	Walker B motif; other site
103690010709	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
103690010710	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690010711	putative Mg++ binding site [ion binding]; other site
103690010712	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690010713	nucleotide binding region [chemical binding]; other site
103690010714	ATP-binding site [chemical binding]; other site
103690010715	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010716	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690010717	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690010718	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
103690010719	NMT1-like family; Region: NMT1_2; pfam13379
103690010720	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
103690010721	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
103690010722	Walker A/P-loop; other site
103690010723	ATP binding site [chemical binding]; other site
103690010724	Q-loop/lid; other site
103690010725	ABC transporter signature motif; other site
103690010726	Walker B; other site
103690010727	D-loop; other site
103690010728	H-loop/switch region; other site
103690010729	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
103690010730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690010731	dimer interface [polypeptide binding]; other site
103690010732	conserved gate region; other site
103690010733	putative PBP binding loops; other site
103690010734	ABC-ATPase subunit interface; other site
103690010735	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
103690010736	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
103690010737	NADP binding site [chemical binding]; other site
103690010738	active site
103690010739	putative substrate binding site [chemical binding]; other site
103690010740	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690010741	catalytic core [active]
103690010742	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690010743	catalytic core [active]
103690010744	dihydroorotase; Provisional; Region: PRK07369
103690010745	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
103690010746	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
103690010747	active site
103690010748	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
103690010749	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
103690010750	Cysteine-rich domain; Region: CCG; pfam02754
103690010751	Cysteine-rich domain; Region: CCG; pfam02754
103690010752	acyl carrier protein; Provisional; Region: acpP; PRK00982
103690010753	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
103690010754	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
103690010755	dimer interface [polypeptide binding]; other site
103690010756	active site
103690010757	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
103690010758	transketolase; Region: PLN02790
103690010759	TPP-binding site [chemical binding]; other site
103690010760	dimer interface [polypeptide binding]; other site
103690010761	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
103690010762	PYR/PP interface [polypeptide binding]; other site
103690010763	dimer interface [polypeptide binding]; other site
103690010764	TPP binding site [chemical binding]; other site
103690010765	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
103690010766	Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462
103690010767	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690010768	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690010769	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690010770	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690010771	Calx-beta domain; Region: Calx-beta; pfam03160
103690010772	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690010773	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690010774	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
103690010775	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
103690010776	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
103690010777	ATP binding site [chemical binding]; other site
103690010778	Mg2+ binding site [ion binding]; other site
103690010779	G-X-G motif; other site
103690010780	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690010781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010782	active site
103690010783	phosphorylation site [posttranslational modification]
103690010784	intermolecular recognition site; other site
103690010785	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
103690010786	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
103690010787	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
103690010788	putative active site [active]
103690010789	Zn binding site [ion binding]; other site
103690010790	glutamate--cysteine ligase, cyanobacterial, putative; Region: gshA_cyano; TIGR02048
103690010791	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
103690010792	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
103690010793	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690010794	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690010795	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
103690010796	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690010797	S-adenosylmethionine binding site [chemical binding]; other site
103690010798	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
103690010799	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
103690010800	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690010801	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690010802	Uncharacterized conserved protein [Function unknown]; Region: COG1565
103690010803	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
103690010804	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
103690010805	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690010806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690010807	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690010808	ATP binding site [chemical binding]; other site
103690010809	Mg2+ binding site [ion binding]; other site
103690010810	G-X-G motif; other site
103690010811	Predicted permeases [General function prediction only]; Region: COG0701
103690010812	Predicted membrane protein [Function unknown]; Region: COG3689
103690010813	Bacterial Ig-like domain; Region: Big_5; pfam13205
103690010814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690010815	AAA domain; Region: AAA_22; pfam13401
103690010816	Walker A motif; other site
103690010817	ATP binding site [chemical binding]; other site
103690010818	Walker B motif; other site
103690010819	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690010820	binding surface
103690010821	TPR motif; other site
103690010822	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690010823	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
103690010824	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
103690010825	putative ADP-binding pocket [chemical binding]; other site
103690010826	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690010827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690010828	Probable transposase; Region: OrfB_IS605; pfam01385
103690010829	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690010830	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
103690010831	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
103690010832	Walker A/P-loop; other site
103690010833	ATP binding site [chemical binding]; other site
103690010834	Q-loop/lid; other site
103690010835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690010836	ABC transporter signature motif; other site
103690010837	Walker B; other site
103690010838	D-loop; other site
103690010839	H-loop/switch region; other site
103690010840	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
103690010841	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
103690010842	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690010843	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
103690010844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690010845	motif II; other site
103690010846	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
103690010847	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
103690010848	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
103690010849	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
103690010850	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
103690010851	NlpC/P60 family; Region: NLPC_P60; pfam00877
103690010852	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
103690010853	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
103690010854	Ligand binding site; other site
103690010855	Putative Catalytic site; other site
103690010856	DXD motif; other site
103690010857	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690010858	Major Facilitator Superfamily; Region: MFS_1; pfam07690
103690010859	putative substrate translocation pore; other site
103690010860	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
103690010861	trimer interface [polypeptide binding]; other site
103690010862	dimer interface [polypeptide binding]; other site
103690010863	putative active site [active]
103690010864	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
103690010865	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690010866	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690010867	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
103690010868	Response regulator receiver domain; Region: Response_reg; pfam00072
103690010869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690010870	active site
103690010871	phosphorylation site [posttranslational modification]
103690010872	intermolecular recognition site; other site
103690010873	dimerization interface [polypeptide binding]; other site
103690010874	2TM domain; Region: 2TM; pfam13239
103690010875	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
103690010876	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
103690010877	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
103690010878	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
103690010879	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
103690010880	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
103690010881	Predicted membrane protein [Function unknown]; Region: COG2323
103690010882	adenylosuccinate lyase; Provisional; Region: PRK07380
103690010883	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
103690010884	tetramer interface [polypeptide binding]; other site
103690010885	active site
103690010886	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
103690010887	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
103690010888	MgtC family; Region: MgtC; pfam02308
103690010889	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
103690010890	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
103690010891	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
103690010892	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
103690010893	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
103690010894	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
103690010895	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
103690010896	active site
103690010897	Substrate binding site; other site
103690010898	Mg++ binding site; other site
103690010899	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
103690010900	putative trimer interface [polypeptide binding]; other site
103690010901	putative CoA binding site [chemical binding]; other site
103690010902	arginine decarboxylase; Provisional; Region: PRK05354
103690010903	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
103690010904	dimer interface [polypeptide binding]; other site
103690010905	active site
103690010906	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
103690010907	catalytic residues [active]
103690010908	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
103690010909	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
103690010910	active site
103690010911	Integral membrane protein TerC family; Region: TerC; cl10468
103690010912	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690010913	Predicted ATPases [General function prediction only]; Region: COG1106
103690010914	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690010915	Walker A/P-loop; other site
103690010916	ATP binding site [chemical binding]; other site
103690010917	RloB-like protein; Region: RloB; pfam13707
103690010918	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
103690010919	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
103690010920	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
103690010921	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
103690010922	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
103690010923	ligand binding site [chemical binding]; other site
103690010924	homodimer interface [polypeptide binding]; other site
103690010925	NAD(P) binding site [chemical binding]; other site
103690010926	trimer interface B [polypeptide binding]; other site
103690010927	trimer interface A [polypeptide binding]; other site
103690010928	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690010929	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
103690010930	ribonuclease P; Reviewed; Region: rnpA; PRK03031
103690010931	Bacterial PH domain; Region: DUF304; pfam03703
103690010932	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
103690010933	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
103690010934	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
103690010935	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
103690010936	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
103690010937	G-X-X-G motif; other site
103690010938	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
103690010939	RxxxH motif; other site
103690010940	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
103690010941	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
103690010942	Peptidase family M50; Region: Peptidase_M50; pfam02163
103690010943	active site
103690010944	putative substrate binding region [chemical binding]; other site
103690010945	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690010946	carboxyl-terminal processing protease; Provisional; Region: PLN00049
103690010947	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
103690010948	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
103690010949	protein binding site [polypeptide binding]; other site
103690010950	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
103690010951	Catalytic dyad [active]
103690010952	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
103690010953	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
103690010954	Qi binding site; other site
103690010955	intrachain domain interface; other site
103690010956	interchain domain interface [polypeptide binding]; other site
103690010957	heme bH binding site [chemical binding]; other site
103690010958	heme bL binding site [chemical binding]; other site
103690010959	Qo binding site; other site
103690010960	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
103690010961	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
103690010962	interchain domain interface [polypeptide binding]; other site
103690010963	intrachain domain interface; other site
103690010964	Qi binding site; other site
103690010965	Qo binding site; other site
103690010966	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
103690010967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
103690010968	ATP binding site [chemical binding]; other site
103690010969	Mg2+ binding site [ion binding]; other site
103690010970	G-X-G motif; other site
103690010971	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
103690010972	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
103690010973	NADP-binding site; other site
103690010974	homotetramer interface [polypeptide binding]; other site
103690010975	substrate binding site [chemical binding]; other site
103690010976	homodimer interface [polypeptide binding]; other site
103690010977	active site
103690010978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690010979	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690010980	Rubrerythrin [Energy production and conversion]; Region: COG1592
103690010981	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
103690010982	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
103690010983	23S rRNA binding site [nucleotide binding]; other site
103690010984	L21 binding site [polypeptide binding]; other site
103690010985	L13 binding site [polypeptide binding]; other site
103690010986	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690010987	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
103690010988	substrate binding pocket [chemical binding]; other site
103690010989	membrane-bound complex binding site; other site
103690010990	hinge residues; other site
103690010991	TPR repeat; Region: TPR_11; pfam13414
103690010992	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690010993	binding surface
103690010994	TPR motif; other site
103690010995	TPR repeat; Region: TPR_11; pfam13414
103690010996	Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733
103690010997	Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727
103690010998	Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728
103690010999	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
103690011000	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
103690011001	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
103690011002	catalytic residue [active]
103690011003	putative FPP diphosphate  binding site; other site
103690011004	putative FPP binding hydrophobic cleft; other site
103690011005	dimer interface [polypeptide binding]; other site
103690011006	putative IPP diphosphate binding site; other site
103690011007	Abortive infection C-terminus; Region: Abi_C; pfam14355
103690011008	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690011009	putative active site [active]
103690011010	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
103690011011	active site
103690011012	AAA ATPase domain; Region: AAA_16; pfam13191
103690011013	NACHT domain; Region: NACHT; pfam05729
103690011014	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690011015	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011016	TPR motif; other site
103690011017	binding surface
103690011018	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011019	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
103690011020	GIY-YIG motif/motif A; other site
103690011021	active site
103690011022	catalytic site [active]
103690011023	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
103690011024	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
103690011025	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
103690011026	PAS fold; Region: PAS_3; pfam08447
103690011027	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011028	putative active site [active]
103690011029	heme pocket [chemical binding]; other site
103690011030	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690011031	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011032	putative active site [active]
103690011033	heme pocket [chemical binding]; other site
103690011034	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011035	putative active site [active]
103690011036	heme pocket [chemical binding]; other site
103690011037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011038	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011039	dimer interface [polypeptide binding]; other site
103690011040	phosphorylation site [posttranslational modification]
103690011041	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011042	ATP binding site [chemical binding]; other site
103690011043	Mg2+ binding site [ion binding]; other site
103690011044	G-X-G motif; other site
103690011045	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690011046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690011047	active site
103690011048	phosphorylation site [posttranslational modification]
103690011049	intermolecular recognition site; other site
103690011050	dimerization interface [polypeptide binding]; other site
103690011051	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
103690011052	Glutamine amidotransferase class-I; Region: GATase; pfam00117
103690011053	glutamine binding [chemical binding]; other site
103690011054	catalytic triad [active]
103690011055	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
103690011056	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
103690011057	chorismate binding enzyme; Region: Chorismate_bind; cl10555
103690011058	DNA polymerase III subunit delta; Validated; Region: PRK07452
103690011059	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
103690011060	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
103690011061	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690011062	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690011063	DNA binding residues [nucleotide binding]
103690011064	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
103690011065	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690011066	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690011067	binding surface
103690011068	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690011069	TPR motif; other site
103690011070	TPR repeat; Region: TPR_11; pfam13414
103690011071	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
103690011072	active site
103690011073	SAM binding site [chemical binding]; other site
103690011074	homodimer interface [polypeptide binding]; other site
103690011075	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
103690011076	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
103690011077	active site
103690011078	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
103690011079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
103690011080	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690011081	ATP binding site [chemical binding]; other site
103690011082	putative Mg++ binding site [ion binding]; other site
103690011083	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690011084	nucleotide binding region [chemical binding]; other site
103690011085	ATP-binding site [chemical binding]; other site
103690011086	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
103690011087	homotrimer interaction site [polypeptide binding]; other site
103690011088	putative active site [active]
103690011089	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690011090	active site
103690011091	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
103690011092	DNA protecting protein DprA; Region: dprA; TIGR00732
103690011093	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
103690011094	septum formation inhibitor; Reviewed; Region: minC; PRK00513
103690011095	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
103690011096	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
103690011097	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
103690011098	Switch I; other site
103690011099	Switch II; other site
103690011100	cell division topological specificity factor MinE; Provisional; Region: PRK13988
103690011101	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
103690011102	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
103690011103	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
103690011104	putative active site [active]
103690011105	substrate binding site [chemical binding]; other site
103690011106	putative cosubstrate binding site; other site
103690011107	catalytic site [active]
103690011108	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
103690011109	substrate binding site [chemical binding]; other site
103690011110	photosystem I subunit VII; Region: psaC; CHL00065
103690011111	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
103690011112	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
103690011113	active site
103690011114	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
103690011115	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
103690011116	dimer interface [polypeptide binding]; other site
103690011117	active site
103690011118	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
103690011119	dimer interface [polypeptide binding]; other site
103690011120	active site
103690011121	NACHT domain; Region: NACHT; pfam05729
103690011122	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690011123	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690011124	protein binding surface [polypeptide binding]; other site
103690011125	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690011126	protein binding surface [polypeptide binding]; other site
103690011127	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
103690011128	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690011129	protein binding surface [polypeptide binding]; other site
103690011130	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690011131	protein binding surface [polypeptide binding]; other site
103690011132	HEAT repeats; Region: HEAT_2; pfam13646
103690011133	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690011134	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011135	WD40 repeats; Region: WD40; smart00320
103690011136	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690011137	structural tetrad; other site
103690011138	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690011139	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690011140	structural tetrad; other site
103690011141	WD domain, G-beta repeat; Region: WD40; pfam00400
103690011142	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
103690011143	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
103690011144	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
103690011145	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690011146	putative active site [active]
103690011147	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690011148	G1 box; other site
103690011149	GTP/Mg2+ binding site [chemical binding]; other site
103690011150	G2 box; other site
103690011151	Switch I region; other site
103690011152	G3 box; other site
103690011153	Switch II region; other site
103690011154	G4 box; other site
103690011155	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
103690011156	G1 box; other site
103690011157	GTP/Mg2+ binding site [chemical binding]; other site
103690011158	G2 box; other site
103690011159	G3 box; other site
103690011160	Switch II region; other site
103690011161	G4 box; other site
103690011162	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
103690011163	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
103690011164	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690011165	ATP binding site [chemical binding]; other site
103690011166	putative Mg++ binding site [ion binding]; other site
103690011167	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
103690011168	HsdM N-terminal domain; Region: HsdM_N; pfam12161
103690011169	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690011170	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690011171	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
103690011172	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690011173	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
103690011174	oligomeric interface; other site
103690011175	putative active site [active]
103690011176	homodimer interface [polypeptide binding]; other site
103690011177	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690011178	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690011179	active site
103690011180	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
103690011181	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
103690011182	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
103690011183	MoxR-like ATPases [General function prediction only]; Region: COG0714
103690011184	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690011185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
103690011186	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690011187	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690011188	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690011189	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690011190	hypothetical protein; Region: PHA00652
103690011191	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690011192	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
103690011193	putative active site [active]
103690011194	putative NTP binding site [chemical binding]; other site
103690011195	putative nucleic acid binding site [nucleotide binding]; other site
103690011196	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
103690011197	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
103690011198	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
103690011199	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
103690011200	active site
103690011201	Int/Topo IB signature motif; other site
103690011202	DNA binding site [nucleotide binding]
103690011203	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690011204	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690011205	metal binding site [ion binding]; metal-binding site
103690011206	active site
103690011207	I-site; other site
103690011208	phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324
103690011209	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690011210	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
103690011211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690011212	active site
103690011213	motif I; other site
103690011214	motif II; other site
103690011215	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
103690011216	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690011217	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690011218	NAD(P) binding site [chemical binding]; other site
103690011219	active site
103690011220	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
103690011221	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
103690011222	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
103690011223	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
103690011224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690011225	dimerization interface [polypeptide binding]; other site
103690011226	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690011227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011228	putative active site [active]
103690011229	heme pocket [chemical binding]; other site
103690011230	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011231	dimer interface [polypeptide binding]; other site
103690011232	phosphorylation site [posttranslational modification]
103690011233	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011234	ATP binding site [chemical binding]; other site
103690011235	Mg2+ binding site [ion binding]; other site
103690011236	G-X-G motif; other site
103690011237	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
103690011238	homooctamer interface [polypeptide binding]; other site
103690011239	active site
103690011240	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
103690011241	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690011242	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690011243	binding surface
103690011244	TPR motif; other site
103690011245	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011247	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
103690011248	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
103690011249	ThiS interaction site; other site
103690011250	putative active site [active]
103690011251	tetramer interface [polypeptide binding]; other site
103690011252	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690011253	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690011254	catalytic loop [active]
103690011255	iron binding site [ion binding]; other site
103690011256	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
103690011257	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
103690011258	active site
103690011259	catalytic residues [active]
103690011260	metal binding site [ion binding]; metal-binding site
103690011261	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
103690011262	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
103690011263	Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150
103690011264	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
103690011265	ATP binding site [chemical binding]; other site
103690011266	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
103690011267	hypothetical protein; Reviewed; Region: PRK09588
103690011268	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690011269	S-adenosylmethionine binding site [chemical binding]; other site
103690011270	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
103690011271	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690011272	motif II; other site
103690011273	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
103690011274	G1 box; other site
103690011275	GTP/Mg2+ binding site [chemical binding]; other site
103690011276	G2 box; other site
103690011277	Switch I region; other site
103690011278	G3 box; other site
103690011279	Switch II region; other site
103690011280	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
103690011281	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
103690011282	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
103690011283	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
103690011284	active site
103690011285	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
103690011286	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
103690011287	dimer interface [polypeptide binding]; other site
103690011288	ADP-ribose binding site [chemical binding]; other site
103690011289	active site
103690011290	nudix motif; other site
103690011291	metal binding site [ion binding]; metal-binding site
103690011292	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690011293	putative cation:proton antiport protein; Provisional; Region: PRK10669
103690011294	TrkA-N domain; Region: TrkA_N; pfam02254
103690011295	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
103690011296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690011297	Coenzyme A binding pocket [chemical binding]; other site
103690011298	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
103690011299	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
103690011300	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
103690011301	dimerization interface [polypeptide binding]; other site
103690011302	active site
103690011303	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
103690011304	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
103690011305	enolase; Provisional; Region: eno; PRK00077
103690011306	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
103690011307	dimer interface [polypeptide binding]; other site
103690011308	metal binding site [ion binding]; metal-binding site
103690011309	substrate binding pocket [chemical binding]; other site
103690011310	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
103690011311	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
103690011312	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
103690011313	dimer interface [polypeptide binding]; other site
103690011314	substrate binding site [chemical binding]; other site
103690011315	ATP binding site [chemical binding]; other site
103690011316	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
103690011317	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
103690011318	active site
103690011319	catalytic triad [active]
103690011320	CHAT domain; Region: CHAT; pfam12770
103690011321	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690011322	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011323	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011324	dimer interface [polypeptide binding]; other site
103690011325	phosphorylation site [posttranslational modification]
103690011326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011327	ATP binding site [chemical binding]; other site
103690011328	Mg2+ binding site [ion binding]; other site
103690011329	G-X-G motif; other site
103690011330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
103690011331	HEAT repeats; Region: HEAT_2; pfam13646
103690011332	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690011333	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690011334	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
103690011335	EamA-like transporter family; Region: EamA; pfam00892
103690011336	EamA-like transporter family; Region: EamA; pfam00892
103690011337	exopolyphosphatase; Region: exo_poly_only; TIGR03706
103690011338	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
103690011339	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
103690011340	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690011341	acetolactate synthase; Reviewed; Region: PRK08322
103690011342	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
103690011343	PYR/PP interface [polypeptide binding]; other site
103690011344	dimer interface [polypeptide binding]; other site
103690011345	TPP binding site [chemical binding]; other site
103690011346	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
103690011347	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
103690011348	TPP-binding site [chemical binding]; other site
103690011349	dimer interface [polypeptide binding]; other site
103690011350	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
103690011351	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
103690011352	NAD(P) binding site [chemical binding]; other site
103690011353	catalytic residues [active]
103690011354	Protein kinase domain; Region: Pkinase; pfam00069
103690011355	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690011356	active site
103690011357	ATP binding site [chemical binding]; other site
103690011358	substrate binding site [chemical binding]; other site
103690011359	activation loop (A-loop); other site
103690011360	AAA ATPase domain; Region: AAA_16; pfam13191
103690011361	Predicted ATPase [General function prediction only]; Region: COG3899
103690011362	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690011363	GAF domain; Region: GAF; pfam01590
103690011364	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011366	ATP binding site [chemical binding]; other site
103690011367	Mg2+ binding site [ion binding]; other site
103690011368	G-X-G motif; other site
103690011369	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690011370	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690011371	ligand binding site [chemical binding]; other site
103690011372	flexible hinge region; other site
103690011373	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
103690011374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690011375	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
103690011376	4Fe-4S binding domain; Region: Fer4_5; pfam12801
103690011377	4Fe-4S binding domain; Region: Fer4_5; pfam12801
103690011378	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
103690011379	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
103690011380	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
103690011381	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
103690011382	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
103690011383	PAS domain S-box; Region: sensory_box; TIGR00229
103690011384	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011385	putative active site [active]
103690011386	heme pocket [chemical binding]; other site
103690011387	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011388	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011389	ATP binding site [chemical binding]; other site
103690011390	Mg2+ binding site [ion binding]; other site
103690011391	G-X-G motif; other site
103690011392	PAS fold; Region: PAS_4; pfam08448
103690011393	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690011394	putative active site [active]
103690011395	heme pocket [chemical binding]; other site
103690011396	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011398	ATP binding site [chemical binding]; other site
103690011399	Mg2+ binding site [ion binding]; other site
103690011400	G-X-G motif; other site
103690011401	probable methyltransferase domain, EasF family; Region: methyl_EasF; TIGR03439
103690011402	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
103690011403	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
103690011404	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
103690011405	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
103690011406	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
103690011407	Ligand Binding Site [chemical binding]; other site
103690011408	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
103690011409	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
103690011410	tetramerization interface [polypeptide binding]; other site
103690011411	active site
103690011412	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
103690011413	dimer interface [polypeptide binding]; other site
103690011414	substrate binding site [chemical binding]; other site
103690011415	metal binding sites [ion binding]; metal-binding site
103690011416	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690011417	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690011418	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690011419	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
103690011420	protein I interface; other site
103690011421	D2 interface; other site
103690011422	protein T interface; other site
103690011423	chlorophyll binding site; other site
103690011424	beta carotene binding site; other site
103690011425	pheophytin binding site; other site
103690011426	manganese-stabilizing polypeptide interface; other site
103690011427	CP43 interface; other site
103690011428	protein L interface; other site
103690011429	oxygen evolving complex binding site; other site
103690011430	bromide binding site; other site
103690011431	quinone binding site; other site
103690011432	Fe binding site [ion binding]; other site
103690011433	core light harvesting interface; other site
103690011434	cytochrome b559 alpha subunit interface; other site
103690011435	cytochrome c-550 interface; other site
103690011436	protein J interface; other site
103690011437	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
103690011438	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690011439	FeS/SAM binding site; other site
103690011440	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
103690011441	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690011442	ABC-ATPase subunit  interface; other site
103690011443	dimer interface [polypeptide binding]; other site
103690011444	putative PBP binding regions; other site
103690011445	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
103690011446	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
103690011447	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
103690011448	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
103690011449	metal binding site [ion binding]; metal-binding site
103690011450	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
103690011451	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
103690011452	active site
103690011453	PHP Thumb interface [polypeptide binding]; other site
103690011454	metal binding site [ion binding]; metal-binding site
103690011455	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
103690011456	protein-splicing catalytic site; other site
103690011457	thioester formation/cholesterol transfer; other site
103690011458	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296
103690011459	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690011460	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
103690011461	active site
103690011462	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690011463	binding surface
103690011464	TPR motif; other site
103690011465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690011466	binding surface
103690011467	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011468	TPR motif; other site
103690011469	Uncharacterized conserved protein [Function unknown]; Region: COG5502
103690011470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011471	dimer interface [polypeptide binding]; other site
103690011472	phosphorylation site [posttranslational modification]
103690011473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011474	ATP binding site [chemical binding]; other site
103690011475	Mg2+ binding site [ion binding]; other site
103690011476	G-X-G motif; other site
103690011477	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690011478	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690011479	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
103690011480	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
103690011481	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
103690011482	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
103690011483	polyphosphate kinase; Provisional; Region: PRK05443
103690011484	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
103690011485	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
103690011486	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
103690011487	putative domain interface [polypeptide binding]; other site
103690011488	putative active site [active]
103690011489	catalytic site [active]
103690011490	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
103690011491	putative domain interface [polypeptide binding]; other site
103690011492	putative active site [active]
103690011493	catalytic site [active]
103690011494	Response regulator receiver domain; Region: Response_reg; pfam00072
103690011495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690011496	active site
103690011497	phosphorylation site [posttranslational modification]
103690011498	intermolecular recognition site; other site
103690011499	dimerization interface [polypeptide binding]; other site
103690011500	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
103690011501	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
103690011502	Response regulator receiver domain; Region: Response_reg; pfam00072
103690011503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690011504	active site
103690011505	phosphorylation site [posttranslational modification]
103690011506	intermolecular recognition site; other site
103690011507	dimerization interface [polypeptide binding]; other site
103690011508	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690011509	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690011510	metal binding site [ion binding]; metal-binding site
103690011511	active site
103690011512	I-site; other site
103690011513	adaptive-response sensory kinase; Validated; Region: PRK09303
103690011514	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
103690011515	tetramer interface [polypeptide binding]; other site
103690011516	dimer interface [polypeptide binding]; other site
103690011517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011518	dimer interface [polypeptide binding]; other site
103690011519	phosphorylation site [posttranslational modification]
103690011520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011521	ATP binding site [chemical binding]; other site
103690011522	Mg2+ binding site [ion binding]; other site
103690011523	G-X-G motif; other site
103690011524	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
103690011525	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
103690011526	acyl-activating enzyme (AAE) consensus motif; other site
103690011527	putative AMP binding site [chemical binding]; other site
103690011528	putative active site [active]
103690011529	putative CoA binding site [chemical binding]; other site
103690011530	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
103690011531	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
103690011532	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
103690011533	E3 interaction surface; other site
103690011534	lipoyl attachment site [posttranslational modification]; other site
103690011535	e3 binding domain; Region: E3_binding; pfam02817
103690011536	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
103690011537	TPR repeat; Region: TPR_11; pfam13414
103690011538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690011539	binding surface
103690011540	TPR motif; other site
103690011541	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690011542	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
103690011543	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
103690011544	S-layer homology domain; Region: SLH; pfam00395
103690011545	S-layer homology domain; Region: SLH; pfam00395
103690011546	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
103690011547	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690011548	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690011549	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690011550	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690011551	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
103690011552	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
103690011553	DNA binding residues [nucleotide binding]
103690011554	putative dimer interface [polypeptide binding]; other site
103690011555	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690011556	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690011557	Uncharacterized conserved protein [Function unknown]; Region: COG3472
103690011558	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
103690011559	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
103690011560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690011561	ATP binding site [chemical binding]; other site
103690011562	putative Mg++ binding site [ion binding]; other site
103690011563	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
103690011564	HsdM N-terminal domain; Region: HsdM_N; pfam12161
103690011565	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690011566	S-adenosylmethionine binding site [chemical binding]; other site
103690011567	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
103690011568	putative active site [active]
103690011569	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690011570	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690011571	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690011572	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
103690011573	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690011574	Divergent AAA domain; Region: AAA_4; pfam04326
103690011575	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690011576	non-specific DNA binding site [nucleotide binding]; other site
103690011577	salt bridge; other site
103690011578	sequence-specific DNA binding site [nucleotide binding]; other site
103690011579	Bacterial TniB protein; Region: TniB; pfam05621
103690011580	AAA domain; Region: AAA_22; pfam13401
103690011581	Winged helix-turn helix; Region: HTH_29; pfam13551
103690011582	Homeodomain-like domain; Region: HTH_23; pfam13384
103690011583	Integrase core domain; Region: rve; pfam00665
103690011584	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
103690011585	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
103690011586	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
103690011587	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690011588	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
103690011589	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
103690011590	M42 glutamyl aminopeptidase; Region: Peptidase_M42; pfam05343
103690011591	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
103690011592	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
103690011593	active site
103690011594	catalytic triad [active]
103690011595	oxyanion hole [active]
103690011596	S-layer homology domain; Region: SLH; pfam00395
103690011597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690011598	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690011599	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690011600	MutS domain III; Region: MutS_III; pfam05192
103690011601	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
103690011602	Walker A/P-loop; other site
103690011603	ATP binding site [chemical binding]; other site
103690011604	Q-loop/lid; other site
103690011605	ABC transporter signature motif; other site
103690011606	Walker B; other site
103690011607	D-loop; other site
103690011608	H-loop/switch region; other site
103690011609	TIGR04255 family protein; Region: sporadTIGR04255
103690011610	cell division protein; Validated; Region: ftsH; CHL00176
103690011611	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690011612	Walker A motif; other site
103690011613	ATP binding site [chemical binding]; other site
103690011614	Walker B motif; other site
103690011615	arginine finger; other site
103690011616	Peptidase family M41; Region: Peptidase_M41; pfam01434
103690011617	aspartate kinase; Provisional; Region: PRK07431
103690011618	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
103690011619	putative nucleotide binding site [chemical binding]; other site
103690011620	putative catalytic residues [active]
103690011621	putative Mg ion binding site [ion binding]; other site
103690011622	putative aspartate binding site [chemical binding]; other site
103690011623	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
103690011624	putative allosteric regulatory site; other site
103690011625	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
103690011626	putative allosteric regulatory residue; other site
103690011627	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
103690011628	putative allosteric regulatory site; other site
103690011629	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
103690011630	putative allosteric regulatory residue; other site
103690011631	XisI protein; Region: XisI; pfam08869
103690011632	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690011633	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690011634	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690011635	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690011636	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690011637	DevC protein; Region: devC; TIGR01185
103690011638	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690011639	FtsX-like permease family; Region: FtsX; pfam02687
103690011640	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
103690011641	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690011642	Walker A/P-loop; other site
103690011643	ATP binding site [chemical binding]; other site
103690011644	Q-loop/lid; other site
103690011645	ABC transporter signature motif; other site
103690011646	Walker B; other site
103690011647	D-loop; other site
103690011648	H-loop/switch region; other site
103690011649	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690011650	putative active site [active]
103690011651	amidophosphoribosyltransferase; Provisional; Region: PRK07349
103690011652	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
103690011653	active site
103690011654	tetramer interface [polypeptide binding]; other site
103690011655	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690011656	active site
103690011657	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
103690011658	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
103690011659	dimerization interface [polypeptide binding]; other site
103690011660	ATP binding site [chemical binding]; other site
103690011661	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
103690011662	dimerization interface [polypeptide binding]; other site
103690011663	ATP binding site [chemical binding]; other site
103690011664	Phycobilisome protein; Region: Phycobilisome; cl08227
103690011665	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
103690011666	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
103690011667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690011668	S-adenosylmethionine binding site [chemical binding]; other site
103690011669	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
103690011670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
103690011671	ATP binding site [chemical binding]; other site
103690011672	Mg2+ binding site [ion binding]; other site
103690011673	G-X-G motif; other site
103690011674	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
103690011675	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
103690011676	putative dimer interface [polypeptide binding]; other site
103690011677	putative anticodon binding site; other site
103690011678	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
103690011679	homodimer interface [polypeptide binding]; other site
103690011680	motif 1; other site
103690011681	motif 2; other site
103690011682	active site
103690011683	motif 3; other site
103690011684	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690011685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690011686	active site
103690011687	phosphorylation site [posttranslational modification]
103690011688	intermolecular recognition site; other site
103690011689	dimerization interface [polypeptide binding]; other site
103690011690	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690011691	DNA binding residues [nucleotide binding]
103690011692	dimerization interface [polypeptide binding]; other site
103690011693	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
103690011694	oligomerisation interface [polypeptide binding]; other site
103690011695	mobile loop; other site
103690011696	roof hairpin; other site
103690011697	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
103690011698	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
103690011699	ring oligomerisation interface [polypeptide binding]; other site
103690011700	ATP/Mg binding site [chemical binding]; other site
103690011701	stacking interactions; other site
103690011702	hinge regions; other site
103690011703	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690011704	active site
103690011705	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
103690011706	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
103690011707	alpha-gamma subunit interface [polypeptide binding]; other site
103690011708	beta-gamma subunit interface [polypeptide binding]; other site
103690011709	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
103690011710	gamma-beta subunit interface [polypeptide binding]; other site
103690011711	alpha-beta subunit interface [polypeptide binding]; other site
103690011712	GxxExxY protein; Region: GxxExxY; TIGR04256
103690011713	urease subunit alpha; Reviewed; Region: ureC; PRK13207
103690011714	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
103690011715	subunit interactions [polypeptide binding]; other site
103690011716	active site
103690011717	flap region; other site
103690011718	Response regulator receiver domain; Region: Response_reg; pfam00072
103690011719	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690011720	active site
103690011721	phosphorylation site [posttranslational modification]
103690011722	intermolecular recognition site; other site
103690011723	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011724	dimerization interface [polypeptide binding]; other site
103690011725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690011726	dimer interface [polypeptide binding]; other site
103690011727	phosphorylation site [posttranslational modification]
103690011728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011729	ATP binding site [chemical binding]; other site
103690011730	Mg2+ binding site [ion binding]; other site
103690011731	G-X-G motif; other site
103690011732	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
103690011733	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
103690011734	NAD(P) binding site [chemical binding]; other site
103690011735	catalytic residues [active]
103690011736	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
103690011737	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
103690011738	Moco binding site; other site
103690011739	metal coordination site [ion binding]; other site
103690011740	ribosomal protein L32; Validated; Region: rpl32; CHL00152
103690011741	adhesin; Provisional; Region: PRK09752
103690011742	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690011743	Caspase domain; Region: Peptidase_C14; pfam00656
103690011744	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690011745	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
103690011746	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
103690011747	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
103690011748	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
103690011749	dihydrodipicolinate synthase; Region: dapA; TIGR00674
103690011750	dimer interface [polypeptide binding]; other site
103690011751	active site
103690011752	catalytic residue [active]
103690011753	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
103690011754	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
103690011755	trigger factor; Provisional; Region: tig; PRK01490
103690011756	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
103690011757	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
103690011758	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690011759	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690011760	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690011761	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
103690011762	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
103690011763	oligomer interface [polypeptide binding]; other site
103690011764	active site residues [active]
103690011765	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
103690011766	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
103690011767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690011768	Walker A motif; other site
103690011769	ATP binding site [chemical binding]; other site
103690011770	Walker B motif; other site
103690011771	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
103690011772	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690011773	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690011774	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
103690011775	Acyl transferase domain; Region: Acyl_transf_1; cl08282
103690011776	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
103690011777	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690011778	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
103690011779	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
103690011780	O-Antigen ligase; Region: Wzy_C; pfam04932
103690011781	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690011782	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690011783	active site
103690011784	ATP binding site [chemical binding]; other site
103690011785	substrate binding site [chemical binding]; other site
103690011786	activation loop (A-loop); other site
103690011787	AAA ATPase domain; Region: AAA_16; pfam13191
103690011788	Predicted ATPase [General function prediction only]; Region: COG3899
103690011789	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690011790	GAF domain; Region: GAF; pfam01590
103690011791	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690011792	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690011793	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690011794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690011795	ATP binding site [chemical binding]; other site
103690011796	Mg2+ binding site [ion binding]; other site
103690011797	G-X-G motif; other site
103690011798	mechanosensitive channel MscS; Provisional; Region: PRK10334
103690011799	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690011800	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690011801	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690011802	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
103690011803	dimerization interface [polypeptide binding]; other site
103690011804	putative active cleft [active]
103690011805	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
103690011806	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690011807	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690011808	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690011809	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690011810	BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616
103690011811	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
103690011812	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
103690011813	Predicted permeases [General function prediction only]; Region: COG0679
103690011814	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
103690011815	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690011816	active site
103690011817	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
103690011818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690011819	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690011820	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690011821	active site
103690011822	ATP binding site [chemical binding]; other site
103690011823	substrate binding site [chemical binding]; other site
103690011824	activation loop (A-loop); other site
103690011825	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
103690011826	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690011827	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690011828	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690011829	DevC protein; Region: devC; TIGR01185
103690011830	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690011831	FtsX-like permease family; Region: FtsX; pfam02687
103690011832	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
103690011833	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690011834	Walker A/P-loop; other site
103690011835	ATP binding site [chemical binding]; other site
103690011836	Q-loop/lid; other site
103690011837	ABC transporter signature motif; other site
103690011838	Walker B; other site
103690011839	D-loop; other site
103690011840	H-loop/switch region; other site
103690011841	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
103690011842	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690011843	active site
103690011844	motif I; other site
103690011845	motif II; other site
103690011846	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
103690011847	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
103690011848	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
103690011849	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
103690011850	arginine-tRNA ligase; Region: PLN02286
103690011851	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
103690011852	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
103690011853	active site
103690011854	HIGH motif; other site
103690011855	KMSK motif region; other site
103690011856	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
103690011857	tRNA binding surface [nucleotide binding]; other site
103690011858	anticodon binding site; other site
103690011859	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690011860	putative active site [active]
103690011861	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
103690011862	metal-binding site [ion binding]
103690011863	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
103690011864	active site
103690011865	SAM binding site [chemical binding]; other site
103690011866	putative homodimer interface [polypeptide binding]; other site
103690011867	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
103690011868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690011869	S-adenosylmethionine binding site [chemical binding]; other site
103690011870	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
103690011871	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
103690011872	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690011873	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
103690011874	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
103690011875	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690011876	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
103690011877	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
103690011878	Aspartase; Region: Aspartase; cd01357
103690011879	active sites [active]
103690011880	tetramer interface [polypeptide binding]; other site
103690011881	Uncharacterized conserved protein [Function unknown]; Region: COG2006
103690011882	Domain of unknown function (DUF362); Region: DUF362; pfam04015
103690011883	light-harvesting-like protein 3; Provisional; Region: PLN00014
103690011884	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
103690011885	protein I interface; other site
103690011886	D2 interface; other site
103690011887	protein T interface; other site
103690011888	chlorophyll binding site; other site
103690011889	beta carotene binding site; other site
103690011890	pheophytin binding site; other site
103690011891	manganese-stabilizing polypeptide interface; other site
103690011892	CP43 interface; other site
103690011893	protein L interface; other site
103690011894	oxygen evolving complex binding site; other site
103690011895	bromide binding site; other site
103690011896	quinone binding site; other site
103690011897	Fe binding site [ion binding]; other site
103690011898	core light harvesting interface; other site
103690011899	cytochrome b559 alpha subunit interface; other site
103690011900	cytochrome c-550 interface; other site
103690011901	protein J interface; other site
103690011902	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690011903	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690011904	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
103690011905	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
103690011906	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
103690011907	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690011908	S-adenosylmethionine binding site [chemical binding]; other site
103690011909	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
103690011910	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
103690011911	active site
103690011912	metal binding site [ion binding]; metal-binding site
103690011913	Protein kinase domain; Region: Pkinase; pfam00069
103690011914	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690011915	active site
103690011916	ATP binding site [chemical binding]; other site
103690011917	substrate binding site [chemical binding]; other site
103690011918	activation loop (A-loop); other site
103690011919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690011920	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690011921	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690011922	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
103690011923	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
103690011924	putative active site; other site
103690011925	catalytic residue [active]
103690011926	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690011927	putative active site [active]
103690011928	tellurium resistance terB-like protein; Region: terB_like; cd07177
103690011929	metal binding site [ion binding]; metal-binding site
103690011930	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690011931	GTPase CgtA; Reviewed; Region: obgE; PRK12299
103690011932	GTP1/OBG; Region: GTP1_OBG; pfam01018
103690011933	Obg GTPase; Region: Obg; cd01898
103690011934	G1 box; other site
103690011935	GTP/Mg2+ binding site [chemical binding]; other site
103690011936	Switch I region; other site
103690011937	G2 box; other site
103690011938	G3 box; other site
103690011939	Switch II region; other site
103690011940	G4 box; other site
103690011941	G5 box; other site
103690011942	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690011943	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011944	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011945	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011946	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011947	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690011948	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
103690011949	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
103690011950	FMN binding site [chemical binding]; other site
103690011951	substrate binding site [chemical binding]; other site
103690011952	putative catalytic residue [active]
103690011953	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
103690011954	pheophytin binding site; other site
103690011955	chlorophyll binding site; other site
103690011956	quinone binding site; other site
103690011957	Fe binding site [ion binding]; other site
103690011958	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690011959	dimerization interface [polypeptide binding]; other site
103690011960	putative DNA binding site [nucleotide binding]; other site
103690011961	putative Zn2+ binding site [ion binding]; other site
103690011962	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
103690011963	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690011964	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
103690011965	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690011966	Cytochrome P450; Region: p450; pfam00067
103690011967	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
103690011968	Isochorismatase family; Region: Isochorismatase; pfam00857
103690011969	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
103690011970	catalytic triad [active]
103690011971	conserved cis-peptide bond; other site
103690011972	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
103690011973	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
103690011974	active site
103690011975	putative substrate binding pocket [chemical binding]; other site
103690011976	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690011977	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690011978	S-adenosylmethionine binding site [chemical binding]; other site
103690011979	ferrochelatase; Reviewed; Region: hemH; PRK00035
103690011980	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
103690011981	active site
103690011982	C-terminal domain interface [polypeptide binding]; other site
103690011983	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
103690011984	active site
103690011985	N-terminal domain interface [polypeptide binding]; other site
103690011986	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690011987	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
103690011988	classical (c) SDRs; Region: SDR_c; cd05233
103690011989	NAD(P) binding site [chemical binding]; other site
103690011990	active site
103690011991	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
103690011992	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
103690011993	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
103690011994	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690011995	active site
103690011996	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690011997	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
103690011998	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690011999	anti sigma factor interaction site; other site
103690012000	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
103690012001	regulatory phosphorylation site [posttranslational modification]; other site
103690012002	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012003	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012004	active site
103690012005	phosphorylation site [posttranslational modification]
103690012006	intermolecular recognition site; other site
103690012007	dimerization interface [polypeptide binding]; other site
103690012008	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
103690012009	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
103690012010	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
103690012011	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
103690012012	Mg2+ binding site [ion binding]; other site
103690012013	G-X-G motif; other site
103690012014	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690012015	GAF domain; Region: GAF; pfam01590
103690012016	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
103690012017	PAS domain; Region: PAS_9; pfam13426
103690012018	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690012019	putative active site [active]
103690012020	heme pocket [chemical binding]; other site
103690012021	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690012022	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690012023	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690012024	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690012025	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690012026	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012027	dimer interface [polypeptide binding]; other site
103690012028	phosphorylation site [posttranslational modification]
103690012029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012030	ATP binding site [chemical binding]; other site
103690012031	Mg2+ binding site [ion binding]; other site
103690012032	G-X-G motif; other site
103690012033	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012034	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012035	active site
103690012036	phosphorylation site [posttranslational modification]
103690012037	intermolecular recognition site; other site
103690012038	dimerization interface [polypeptide binding]; other site
103690012039	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012041	active site
103690012042	phosphorylation site [posttranslational modification]
103690012043	intermolecular recognition site; other site
103690012044	dimerization interface [polypeptide binding]; other site
103690012045	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690012046	putative binding surface; other site
103690012047	active site
103690012048	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
103690012049	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
103690012050	peptide binding site [polypeptide binding]; other site
103690012051	dimer interface [polypeptide binding]; other site
103690012052	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012053	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012054	active site
103690012055	phosphorylation site [posttranslational modification]
103690012056	intermolecular recognition site; other site
103690012057	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690012058	dimerization interface [polypeptide binding]; other site
103690012059	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012060	dimer interface [polypeptide binding]; other site
103690012061	phosphorylation site [posttranslational modification]
103690012062	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012063	ATP binding site [chemical binding]; other site
103690012064	Mg2+ binding site [ion binding]; other site
103690012065	G-X-G motif; other site
103690012066	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690012067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012068	active site
103690012069	phosphorylation site [posttranslational modification]
103690012070	intermolecular recognition site; other site
103690012071	dimerization interface [polypeptide binding]; other site
103690012072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012073	dimer interface [polypeptide binding]; other site
103690012074	phosphorylation site [posttranslational modification]
103690012075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012076	ATP binding site [chemical binding]; other site
103690012077	Mg2+ binding site [ion binding]; other site
103690012078	G-X-G motif; other site
103690012079	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012081	active site
103690012082	phosphorylation site [posttranslational modification]
103690012083	intermolecular recognition site; other site
103690012084	dimerization interface [polypeptide binding]; other site
103690012085	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690012086	putative active site [active]
103690012087	heme pocket [chemical binding]; other site
103690012088	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690012089	PAS fold; Region: PAS_3; pfam08447
103690012090	putative active site [active]
103690012091	heme pocket [chemical binding]; other site
103690012092	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012093	dimer interface [polypeptide binding]; other site
103690012094	phosphorylation site [posttranslational modification]
103690012095	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012096	ATP binding site [chemical binding]; other site
103690012097	Mg2+ binding site [ion binding]; other site
103690012098	G-X-G motif; other site
103690012099	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690012100	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012101	active site
103690012102	phosphorylation site [posttranslational modification]
103690012103	intermolecular recognition site; other site
103690012104	dimerization interface [polypeptide binding]; other site
103690012105	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690012106	DNA binding residues [nucleotide binding]
103690012107	dimerization interface [polypeptide binding]; other site
103690012108	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
103690012109	Uncharacterized Candidatus kuenenia aldehyde dehydrogenase AldH (CAJ73105)-like; Region: ALDH_AldH-CAJ73105; cd07131
103690012110	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
103690012111	NAD binding site [chemical binding]; other site
103690012112	catalytic residues [active]
103690012113	Protein kinase domain; Region: Pkinase; pfam00069
103690012114	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690012115	active site
103690012116	ATP binding site [chemical binding]; other site
103690012117	substrate binding site [chemical binding]; other site
103690012118	activation loop (A-loop); other site
103690012119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012120	binding surface
103690012121	TPR motif; other site
103690012122	TPR repeat; Region: TPR_11; pfam13414
103690012123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012124	binding surface
103690012125	TPR motif; other site
103690012126	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
103690012127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012128	binding surface
103690012129	TPR motif; other site
103690012130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012131	binding surface
103690012132	TPR motif; other site
103690012133	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
103690012134	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690012135	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690012136	phosphopeptide binding site; other site
103690012137	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
103690012138	putative active site [active]
103690012139	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012141	binding surface
103690012142	TPR motif; other site
103690012143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012144	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012145	binding surface
103690012146	TPR motif; other site
103690012147	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012150	binding surface
103690012151	TPR motif; other site
103690012152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012153	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
103690012154	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
103690012155	metal-binding site [ion binding]
103690012156	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690012157	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690012158	motif II; other site
103690012159	TM2 domain; Region: TM2; cl00984
103690012160	CAAX protease self-immunity; Region: Abi; pfam02517
103690012161	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
103690012162	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
103690012163	G1 box; other site
103690012164	GTP/Mg2+ binding site [chemical binding]; other site
103690012165	Switch I region; other site
103690012166	G2 box; other site
103690012167	Switch II region; other site
103690012168	G3 box; other site
103690012169	G4 box; other site
103690012170	G5 box; other site
103690012171	Domain of unknown function (DUF697); Region: DUF697; pfam05128
103690012172	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690012173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012174	active site
103690012175	phosphorylation site [posttranslational modification]
103690012176	intermolecular recognition site; other site
103690012177	dimerization interface [polypeptide binding]; other site
103690012178	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690012179	DNA binding site [nucleotide binding]
103690012180	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690012181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690012182	Walker A motif; other site
103690012183	ATP binding site [chemical binding]; other site
103690012184	Walker B motif; other site
103690012185	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
103690012186	active site residue [active]
103690012187	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
103690012188	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
103690012189	catalytic site [active]
103690012190	putative active site [active]
103690012191	putative substrate binding site [chemical binding]; other site
103690012192	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
103690012193	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
103690012194	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
103690012195	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
103690012196	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
103690012197	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
103690012198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690012199	catalytic residue [active]
103690012200	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
103690012201	putative rRNA binding site [nucleotide binding]; other site
103690012202	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
103690012203	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690012204	Fasciclin domain; Region: Fasciclin; pfam02469
103690012205	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690012206	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
103690012207	C-terminal domain interface [polypeptide binding]; other site
103690012208	GSH binding site (G-site) [chemical binding]; other site
103690012209	dimer interface [polypeptide binding]; other site
103690012210	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
103690012211	N-terminal domain interface [polypeptide binding]; other site
103690012212	HAS barrel domain; Region: HAS-barrel; pfam09378
103690012213	HerA helicase [Replication, recombination, and repair]; Region: COG0433
103690012214	Domain of unknown function DUF87; Region: DUF87; pfam01935
103690012215	RNA polymerase sigma factor; Validated; Region: PRK05949
103690012216	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690012217	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690012218	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690012219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690012220	DNA binding residues [nucleotide binding]
103690012221	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
103690012222	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
103690012223	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
103690012224	homodimer interface [polypeptide binding]; other site
103690012225	Walker A motif; other site
103690012226	ATP binding site [chemical binding]; other site
103690012227	hydroxycobalamin binding site [chemical binding]; other site
103690012228	Walker B motif; other site
103690012229	deoxyhypusine synthase-like protein; Provisional; Region: PRK00770
103690012230	deoxyhypusine synthase; Region: dhys; TIGR00321
103690012231	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
103690012232	dihydropteridine reductase (DHPR), classical (c) SDRs; Region: DHPR_SDR_c_like; cd05334
103690012233	NAD binding site [chemical binding]; other site
103690012234	homodimer interface [polypeptide binding]; other site
103690012235	active site
103690012236	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
103690012237	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
103690012238	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012239	binding surface
103690012240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012241	TPR motif; other site
103690012242	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012244	binding surface
103690012245	TPR motif; other site
103690012246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012247	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012248	binding surface
103690012249	TPR motif; other site
103690012250	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012251	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012253	binding surface
103690012254	TPR motif; other site
103690012255	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012256	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
103690012257	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
103690012258	dimerization interface [polypeptide binding]; other site
103690012259	DPS ferroxidase diiron center [ion binding]; other site
103690012260	ion pore; other site
103690012261	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
103690012262	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
103690012263	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
103690012264	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
103690012265	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
103690012266	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690012267	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
103690012268	IMP binding site; other site
103690012269	dimer interface [polypeptide binding]; other site
103690012270	interdomain contacts; other site
103690012271	partial ornithine binding site; other site
103690012272	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
103690012273	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690012274	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690012275	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690012276	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690012277	DNA binding residues [nucleotide binding]
103690012278	Protein of unknown function (DUF760); Region: DUF760; pfam05542
103690012279	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
103690012280	active site
103690012281	8-oxo-dGMP binding site [chemical binding]; other site
103690012282	nudix motif; other site
103690012283	metal binding site [ion binding]; metal-binding site
103690012284	FOG: CBS domain [General function prediction only]; Region: COG0517
103690012285	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
103690012286	HEAT repeats; Region: HEAT_2; pfam13646
103690012287	HEAT repeats; Region: HEAT_2; pfam13646
103690012288	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690012289	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690012290	Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction; Region: CysPc; cl00051
103690012291	catalytic site [active]
103690012292	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690012293	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690012294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839
103690012295	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
103690012296	Ycf27; Reviewed; Region: orf27; CHL00148
103690012297	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012298	active site
103690012299	phosphorylation site [posttranslational modification]
103690012300	intermolecular recognition site; other site
103690012301	dimerization interface [polypeptide binding]; other site
103690012302	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690012303	DNA binding site [nucleotide binding]
103690012304	DNA repair protein RadA; Provisional; Region: PRK11823
103690012305	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
103690012306	Walker A motif/ATP binding site; other site
103690012307	ATP binding site [chemical binding]; other site
103690012308	Walker B motif; other site
103690012309	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
103690012310	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690012311	putative active site [active]
103690012312	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
103690012313	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
103690012314	active site
103690012315	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690012316	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690012317	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690012318	ribosome maturation protein RimP; Reviewed; Region: PRK00092
103690012319	Sm and related proteins; Region: Sm_like; cl00259
103690012320	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
103690012321	putative oligomer interface [polypeptide binding]; other site
103690012322	putative RNA binding site [nucleotide binding]; other site
103690012323	transcription elongation factor NusA; Provisional; Region: nusA; PRK12329
103690012324	NusA N-terminal domain; Region: NusA_N; pfam08529
103690012325	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
103690012326	RNA binding site [nucleotide binding]; other site
103690012327	homodimer interface [polypeptide binding]; other site
103690012328	NusA-like KH domain; Region: KH_5; pfam13184
103690012329	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
103690012330	G-X-X-G motif; other site
103690012331	Predicted nucleic-acid-binding protein implicated in transcription termination [Transcription]; Region: COG2740
103690012332	putative RNA binding cleft [nucleotide binding]; other site
103690012333	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
103690012334	translation initiation factor IF-2; Region: IF-2; TIGR00487
103690012335	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
103690012336	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
103690012337	G1 box; other site
103690012338	putative GEF interaction site [polypeptide binding]; other site
103690012339	GTP/Mg2+ binding site [chemical binding]; other site
103690012340	Switch I region; other site
103690012341	G2 box; other site
103690012342	G3 box; other site
103690012343	Switch II region; other site
103690012344	G4 box; other site
103690012345	G5 box; other site
103690012346	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
103690012347	Translation-initiation factor 2; Region: IF-2; pfam11987
103690012348	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
103690012349	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
103690012350	glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358
103690012351	glucose-1-dehydrogenase; Provisional; Region: PRK08936
103690012352	NAD binding site [chemical binding]; other site
103690012353	homodimer interface [polypeptide binding]; other site
103690012354	active site
103690012355	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690012356	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690012357	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012358	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012359	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012360	binding surface
103690012361	TPR motif; other site
103690012362	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012363	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012365	binding surface
103690012366	TPR motif; other site
103690012367	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012368	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012370	binding surface
103690012371	TPR motif; other site
103690012372	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012373	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690012375	binding surface
103690012376	TPR motif; other site
103690012377	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012378	AAA ATPase domain; Region: AAA_16; pfam13191
103690012379	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
103690012380	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
103690012381	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
103690012382	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
103690012383	Rubredoxin [Energy production and conversion]; Region: COG1773
103690012384	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
103690012385	iron binding site [ion binding]; other site
103690012386	Ycf48-like protein; Provisional; Region: PRK13684
103690012387	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
103690012388	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
103690012389	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
103690012390	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
103690012391	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
103690012392	PsbJ; Region: PsbJ; pfam01788
103690012393	Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205
103690012394	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
103690012395	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690012396	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690012397	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690012398	DNA binding residues [nucleotide binding]
103690012399	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
103690012400	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690012401	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
103690012402	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
103690012403	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
103690012404	cell division protein FtsZ; Validated; Region: PRK09330
103690012405	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
103690012406	nucleotide binding site [chemical binding]; other site
103690012407	SulA interaction site; other site
103690012408	glutathione synthetase; Provisional; Region: PRK05246
103690012409	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
103690012410	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
103690012411	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
103690012412	GSH binding site [chemical binding]; other site
103690012413	catalytic residues [active]
103690012414	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
103690012415	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
103690012416	HflX GTPase family; Region: HflX; cd01878
103690012417	G1 box; other site
103690012418	GTP/Mg2+ binding site [chemical binding]; other site
103690012419	Switch I region; other site
103690012420	G2 box; other site
103690012421	G3 box; other site
103690012422	Switch II region; other site
103690012423	G4 box; other site
103690012424	G5 box; other site
103690012425	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690012426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
103690012427	active site
103690012428	motif I; other site
103690012429	motif II; other site
103690012430	NurA nuclease; Region: NurA; smart00933
103690012431	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
103690012432	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690012433	FeS/SAM binding site; other site
103690012434	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
103690012435	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
103690012436	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
103690012437	[2Fe-2S] cluster binding site [ion binding]; other site
103690012438	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
103690012439	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
103690012440	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690012441	catalytic residue [active]
103690012442	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690012443	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690012444	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690012445	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690012446	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690012447	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
103690012448	homotrimer interaction site [polypeptide binding]; other site
103690012449	putative active site [active]
103690012450	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
103690012451	nudix motif; other site
103690012452	4-alpha-glucanotransferase; Provisional; Region: PRK14508
103690012453	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
103690012454	Helix-turn-helix domain; Region: HTH_25; pfam13413
103690012455	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
103690012456	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
103690012457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
103690012458	RNA binding surface [nucleotide binding]; other site
103690012459	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
103690012460	active site
103690012461	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
103690012462	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
103690012463	phosphatidate cytidylyltransferase; Region: PLN02953
103690012464	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
103690012465	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690012466	S-adenosylmethionine binding site [chemical binding]; other site
103690012467	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690012468	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690012469	active site
103690012470	ATP binding site [chemical binding]; other site
103690012471	substrate binding site [chemical binding]; other site
103690012472	activation loop (A-loop); other site
103690012473	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
103690012474	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
103690012475	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690012476	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690012477	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690012478	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
103690012479	proposed catalytic triad [active]
103690012480	active site nucleophile [active]
103690012481	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
103690012482	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
103690012483	homotrimer interaction site [polypeptide binding]; other site
103690012484	zinc binding site [ion binding]; other site
103690012485	CDP-binding sites; other site
103690012486	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
103690012487	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
103690012488	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
103690012489	AIR carboxylase; Region: AIRC; smart01001
103690012490	argininosuccinate lyase; Provisional; Region: PRK00855
103690012491	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
103690012492	active sites [active]
103690012493	tetramer interface [polypeptide binding]; other site
103690012494	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690012495	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690012496	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
103690012497	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690012498	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690012499	HEAT repeats; Region: HEAT_2; pfam13646
103690012500	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
103690012501	protein binding surface [polypeptide binding]; other site
103690012502	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
103690012503	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
103690012504	protein binding surface [polypeptide binding]; other site
103690012505	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690012506	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690012507	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690012508	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690012509	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690012510	pantothenate kinase; Reviewed; Region: PRK13331
103690012511	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
103690012512	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
103690012513	putative NAD(P) binding site [chemical binding]; other site
103690012514	active site
103690012515	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690012516	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690012517	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
103690012518	nudix motif; other site
103690012519	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
103690012520	Peptidase family M50; Region: Peptidase_M50; pfam02163
103690012521	active site
103690012522	putative substrate binding region [chemical binding]; other site
103690012523	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
103690012524	methionine sulfoxide reductase B; Provisional; Region: PRK00222
103690012525	SelR domain; Region: SelR; pfam01641
103690012526	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
103690012527	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
103690012528	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
103690012529	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690012530	dimerization interface [polypeptide binding]; other site
103690012531	putative DNA binding site [nucleotide binding]; other site
103690012532	putative Zn2+ binding site [ion binding]; other site
103690012533	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
103690012534	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
103690012535	active site residue [active]
103690012536	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
103690012537	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690012538	putative active site [active]
103690012539	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690012540	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690012541	NAD(P) binding site [chemical binding]; other site
103690012542	active site
103690012543	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
103690012544	substrate binding site [chemical binding]; other site
103690012545	active site
103690012546	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
103690012547	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
103690012548	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
103690012549	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
103690012550	active site
103690012551	Zn binding site [ion binding]; other site
103690012552	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
103690012553	CoA binding domain; Region: CoA_binding; smart00881
103690012554	CoA-ligase; Region: Ligase_CoA; pfam00549
103690012555	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
103690012556	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
103690012557	outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049
103690012558	FecR protein; Region: FecR; pfam04773
103690012559	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
103690012560	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
103690012561	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
103690012562	active site residue [active]
103690012563	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
103690012564	active site residue [active]
103690012565	Uncharacterized conserved protein [Function unknown]; Region: COG4121
103690012566	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
103690012567	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012568	active site
103690012569	phosphorylation site [posttranslational modification]
103690012570	intermolecular recognition site; other site
103690012571	dimerization interface [polypeptide binding]; other site
103690012572	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
103690012573	Zn2+ binding site [ion binding]; other site
103690012574	Mg2+ binding site [ion binding]; other site
103690012575	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
103690012576	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
103690012577	Substrate binding site; other site
103690012578	Mg++ binding site; other site
103690012579	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
103690012580	active site
103690012581	substrate binding site [chemical binding]; other site
103690012582	CoA binding site [chemical binding]; other site
103690012583	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
103690012584	active site
103690012585	dimer interface [polypeptide binding]; other site
103690012586	catalytic nucleophile [active]
103690012587	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
103690012588	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
103690012589	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
103690012590	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
103690012591	active site
103690012592	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
103690012593	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690012594	Dynamin family; Region: Dynamin_N; pfam00350
103690012595	G1 box; other site
103690012596	GTP/Mg2+ binding site [chemical binding]; other site
103690012597	G2 box; other site
103690012598	Switch I region; other site
103690012599	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
103690012600	G3 box; other site
103690012601	Switch II region; other site
103690012602	GTP/Mg2+ binding site [chemical binding]; other site
103690012603	G4 box; other site
103690012604	G5 box; other site
103690012605	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690012606	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690012607	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
103690012608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690012609	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690012610	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
103690012611	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690012612	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
103690012613	catalytic triad [active]
103690012614	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
103690012615	IHF dimer interface [polypeptide binding]; other site
103690012616	IHF - DNA interface [nucleotide binding]; other site
103690012617	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
103690012618	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690012619	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690012620	homodimer interface [polypeptide binding]; other site
103690012621	catalytic residue [active]
103690012622	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
103690012623	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690012624	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690012625	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
103690012626	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
103690012627	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
103690012628	putative ligand binding site [chemical binding]; other site
103690012629	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
103690012630	Ferritin-like domain; Region: Ferritin; pfam00210
103690012631	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
103690012632	dinuclear metal binding motif [ion binding]; other site
103690012633	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
103690012634	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
103690012635	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
103690012636	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
103690012637	cobalt transport protein CbiM; Validated; Region: PRK08319
103690012638	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
103690012639	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
103690012640	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
103690012641	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
103690012642	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
103690012643	Walker A/P-loop; other site
103690012644	ATP binding site [chemical binding]; other site
103690012645	Q-loop/lid; other site
103690012646	ABC transporter signature motif; other site
103690012647	Walker B; other site
103690012648	D-loop; other site
103690012649	H-loop/switch region; other site
103690012650	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
103690012651	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
103690012652	PDGLE domain; Region: PDGLE; pfam13190
103690012653	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
103690012654	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
103690012655	Walker A/P-loop; other site
103690012656	ATP binding site [chemical binding]; other site
103690012657	ABC transporter; Region: ABC_tran; pfam00005
103690012658	Q-loop/lid; other site
103690012659	ABC transporter signature motif; other site
103690012660	Walker B; other site
103690012661	D-loop; other site
103690012662	H-loop/switch region; other site
103690012663	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
103690012664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690012665	active site
103690012666	motif I; other site
103690012667	motif II; other site
103690012668	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690012669	DALR anticodon binding domain; Region: DALR_1; smart00836
103690012670	anticodon binding site; other site
103690012671	tRNA binding surface [nucleotide binding]; other site
103690012672	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690012673	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
103690012674	putative switch regulator; other site
103690012675	non-specific DNA interactions [nucleotide binding]; other site
103690012676	DNA binding site [nucleotide binding]
103690012677	sequence specific DNA binding site [nucleotide binding]; other site
103690012678	putative cAMP binding site [chemical binding]; other site
103690012679	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
103690012680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690012681	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
103690012682	putative dimerization interface [polypeptide binding]; other site
103690012683	Predicted membrane protein [Function unknown]; Region: COG4094
103690012684	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
103690012685	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
103690012686	catalytic residues [active]
103690012687	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
103690012688	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
103690012689	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690012690	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
103690012691	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
103690012692	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690012693	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690012694	putative active site [active]
103690012695	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690012696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
103690012697	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
103690012698	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
103690012699	active site
103690012700	substrate binding site [chemical binding]; other site
103690012701	metal binding site [ion binding]; metal-binding site
103690012702	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
103690012703	Leu/Phe-tRNA-protein transferase [Posttranslational modification, protein turnover, chaperones]; Region: Aat; COG2360
103690012704	ribosomal protein S14; Region: rps14; CHL00074
103690012705	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
103690012706	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
103690012707	minor groove reading motif; other site
103690012708	helix-hairpin-helix signature motif; other site
103690012709	substrate binding pocket [chemical binding]; other site
103690012710	active site
103690012711	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
103690012712	RIP metalloprotease RseP; Region: TIGR00054
103690012713	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
103690012714	active site
103690012715	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
103690012716	protein binding site [polypeptide binding]; other site
103690012717	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
103690012718	putative substrate binding region [chemical binding]; other site
103690012719	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690012720	putative active site [active]
103690012721	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
103690012722	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
103690012723	seryl-tRNA synthetase; Provisional; Region: PRK05431
103690012724	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
103690012725	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
103690012726	dimer interface [polypeptide binding]; other site
103690012727	active site
103690012728	motif 1; other site
103690012729	motif 2; other site
103690012730	motif 3; other site
103690012731	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
103690012732	Predicted transcriptional regulators [Transcription]; Region: COG1695
103690012733	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
103690012734	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
103690012735	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
103690012736	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690012737	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012738	dimer interface [polypeptide binding]; other site
103690012739	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012740	ATP binding site [chemical binding]; other site
103690012741	Mg2+ binding site [ion binding]; other site
103690012742	G-X-G motif; other site
103690012743	S-layer homology domain; Region: SLH; pfam00395
103690012744	S-layer homology domain; Region: SLH; pfam00395
103690012745	S-layer homology domain; Region: SLH; pfam00395
103690012746	PAS fold; Region: PAS_4; pfam08448
103690012747	PAS fold; Region: PAS; pfam00989
103690012748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690012749	putative active site [active]
103690012750	heme pocket [chemical binding]; other site
103690012751	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690012752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690012753	dimer interface [polypeptide binding]; other site
103690012754	phosphorylation site [posttranslational modification]
103690012755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690012756	ATP binding site [chemical binding]; other site
103690012757	Mg2+ binding site [ion binding]; other site
103690012758	G-X-G motif; other site
103690012759	Response regulator receiver domain; Region: Response_reg; pfam00072
103690012760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690012761	active site
103690012762	phosphorylation site [posttranslational modification]
103690012763	intermolecular recognition site; other site
103690012764	dimerization interface [polypeptide binding]; other site
103690012765	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690012766	Probable transposase; Region: OrfB_IS605; pfam01385
103690012767	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690012768	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
103690012769	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
103690012770	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
103690012771	Walker A/P-loop; other site
103690012772	ATP binding site [chemical binding]; other site
103690012773	Q-loop/lid; other site
103690012774	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690012775	ABC transporter signature motif; other site
103690012776	Walker B; other site
103690012777	D-loop; other site
103690012778	H-loop/switch region; other site
103690012779	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
103690012780	DHH family; Region: DHH; pfam01368
103690012781	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690012782	FOG: CBS domain [General function prediction only]; Region: COG0517
103690012783	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
103690012784	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
103690012785	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
103690012786	active site
103690012787	NTP binding site [chemical binding]; other site
103690012788	metal binding triad [ion binding]; metal-binding site
103690012789	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
103690012790	Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521
103690012791	active site residue [active]
103690012792	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
103690012793	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
103690012794	homopentamer interface [polypeptide binding]; other site
103690012795	active site
103690012796	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
103690012797	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
103690012798	putative catalytic cysteine [active]
103690012799	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
103690012800	GIY-YIG motif/motif A; other site
103690012801	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690012802	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690012803	active site
103690012804	ATP binding site [chemical binding]; other site
103690012805	substrate binding site [chemical binding]; other site
103690012806	activation loop (A-loop); other site
103690012807	YARHG domain; Region: YARHG; pfam13308
103690012808	Photosystem II protein; Region: PSII; cl08223
103690012809	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
103690012810	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
103690012811	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
103690012812	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
103690012813	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
103690012814	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690012815	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690012816	pyruvate kinase; Provisional; Region: PRK06354
103690012817	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
103690012818	domain interfaces; other site
103690012819	active site
103690012820	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
103690012821	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
103690012822	Fatty acid desaturase; Region: FA_desaturase; pfam00487
103690012823	putative di-iron ligands [ion binding]; other site
103690012824	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690012825	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690012826	ligand binding site [chemical binding]; other site
103690012827	flexible hinge region; other site
103690012828	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
103690012829	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
103690012830	putative NAD(P) binding site [chemical binding]; other site
103690012831	active site
103690012832	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
103690012833	homotrimer interaction site [polypeptide binding]; other site
103690012834	active site
103690012835	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
103690012836	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
103690012837	tandem repeat interface [polypeptide binding]; other site
103690012838	oligomer interface [polypeptide binding]; other site
103690012839	active site residues [active]
103690012840	Colicin pore forming domain; Region: Colicin; pfam01024
103690012841	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
103690012842	Permease; Region: Permease; cl00510
103690012843	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
103690012844	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
103690012845	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
103690012846	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690012847	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
103690012848	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
103690012849	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
103690012850	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
103690012851	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
103690012852	putative active site [active]
103690012853	transaldolase; Provisional; Region: PRK03903
103690012854	catalytic residue [active]
103690012855	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
103690012856	AMP binding site [chemical binding]; other site
103690012857	metal binding site [ion binding]; metal-binding site
103690012858	active site
103690012859	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690012860	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690012861	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
103690012862	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
103690012863	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
103690012864	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
103690012865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690012866	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
103690012867	putative substrate translocation pore; other site
103690012868	AMIN domain; Region: AMIN; pfam11741
103690012869	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
103690012870	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690012871	N-terminal plug; other site
103690012872	ligand-binding site [chemical binding]; other site
103690012873	Predicted metal-binding protein [Function unknown]; Region: COG5469
103690012874	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
103690012875	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690012876	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
103690012877	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
103690012878	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
103690012879	dimer interface [polypeptide binding]; other site
103690012880	[2Fe-2S] cluster binding site [ion binding]; other site
103690012881	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690012882	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
103690012883	putative ligand binding site [chemical binding]; other site
103690012884	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
103690012885	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
103690012886	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
103690012887	ABC-ATPase subunit  interface; other site
103690012888	dimer interface [polypeptide binding]; other site
103690012889	putative PBP binding regions; other site
103690012890	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
103690012891	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
103690012892	Walker A/P-loop; other site
103690012893	ATP binding site [chemical binding]; other site
103690012894	Q-loop/lid; other site
103690012895	ABC transporter signature motif; other site
103690012896	Walker B; other site
103690012897	D-loop; other site
103690012898	H-loop/switch region; other site
103690012899	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
103690012900	Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306
103690012901	protein-splicing catalytic site; other site
103690012902	thioester formation/cholesterol transfer; other site
103690012903	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
103690012904	Homing endonuclease; Region: Hom_end; pfam05204
103690012905	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
103690012906	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
103690012907	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
103690012908	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
103690012909	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
103690012910	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
103690012911	trimer interface [polypeptide binding]; other site
103690012912	active site
103690012913	substrate binding site [chemical binding]; other site
103690012914	CoA binding site [chemical binding]; other site
103690012915	KWG Leptospira; Region: KWG; pfam07656
103690012916	KWG Leptospira; Region: KWG; pfam07656
103690012917	KWG Leptospira; Region: KWG; pfam07656
103690012918	KWG Leptospira; Region: KWG; pfam07656
103690012919	KWG Leptospira; Region: KWG; pfam07656
103690012920	KWG Leptospira; Region: KWG; pfam07656
103690012921	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690012922	putative active site [active]
103690012923	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
103690012924	Member of the Rhodanese Homology Domain superfamily, subgroup 2. Subgroup 2 includes uncharacterized putative rhodanese-related domains; Region: RHOD_2; cd01528
103690012925	active site residue [active]
103690012926	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
103690012927	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
103690012928	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
103690012929	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
103690012930	putative dimer interface [polypeptide binding]; other site
103690012931	N-terminal domain interface [polypeptide binding]; other site
103690012932	putative substrate binding pocket (H-site) [chemical binding]; other site
103690012933	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
103690012934	PRC-barrel domain; Region: PRC; pfam05239
103690012935	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
103690012936	PRC-barrel domain; Region: PRC; pfam05239
103690012937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
103690012938	transketolase; Reviewed; Region: PRK05899
103690012939	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
103690012940	TPP-binding site [chemical binding]; other site
103690012941	dimer interface [polypeptide binding]; other site
103690012942	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
103690012943	PYR/PP interface [polypeptide binding]; other site
103690012944	dimer interface [polypeptide binding]; other site
103690012945	TPP binding site [chemical binding]; other site
103690012946	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
103690012947	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
103690012948	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
103690012949	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
103690012950	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
103690012951	acyl-CoA synthetase; Validated; Region: PRK05850
103690012952	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
103690012953	acyl-activating enzyme (AAE) consensus motif; other site
103690012954	active site
103690012955	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
103690012956	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
103690012957	active site
103690012958	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690012959	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
103690012960	Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752
103690012961	Protein of unknown function, DUF393; Region: DUF393; pfam04134
103690012962	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
103690012963	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
103690012964	Protein of unknown function DUF58; Region: DUF58; pfam01882
103690012965	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
103690012966	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1547
103690012967	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
103690012968	OstA-like protein; Region: OstA; pfam03968
103690012969	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
103690012970	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
103690012971	Walker A/P-loop; other site
103690012972	ATP binding site [chemical binding]; other site
103690012973	Q-loop/lid; other site
103690012974	ABC transporter signature motif; other site
103690012975	Walker B; other site
103690012976	D-loop; other site
103690012977	H-loop/switch region; other site
103690012978	Predicted permeases [General function prediction only]; Region: COG0795
103690012979	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
103690012980	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690012981	AMIN domain; Region: AMIN; pfam11741
103690012982	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
103690012983	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
103690012984	dimer interface [polypeptide binding]; other site
103690012985	putative anticodon binding site; other site
103690012986	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
103690012987	motif 1; other site
103690012988	active site
103690012989	motif 2; other site
103690012990	motif 3; other site
103690012991	KTSC domain; Region: KTSC; pfam13619
103690012992	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690012993	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
103690012994	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
103690012995	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
103690012996	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
103690012997	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
103690012998	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690012999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690013000	binding surface
103690013001	TPR motif; other site
103690013002	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690013003	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
103690013004	active site
103690013005	Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197
103690013006	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
103690013007	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
103690013008	active site
103690013009	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690013010	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690013011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690013012	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690013013	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690013014	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690013015	phosphopeptide binding site; other site
103690013016	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690013017	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690013018	phosphopeptide binding site; other site
103690013019	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
103690013020	Active_site [active]
103690013021	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
103690013022	nucleotide binding site/active site [active]
103690013023	HIT family signature motif; other site
103690013024	catalytic residue [active]
103690013025	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
103690013026	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
103690013027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690013028	Walker A motif; other site
103690013029	ATP binding site [chemical binding]; other site
103690013030	Walker B motif; other site
103690013031	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
103690013032	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
103690013033	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
103690013034	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
103690013035	protein binding site [polypeptide binding]; other site
103690013036	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
103690013037	Domain interface; other site
103690013038	Peptide binding site; other site
103690013039	Active site tetrad [active]
103690013040	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690013041	HSP70 interaction site [polypeptide binding]; other site
103690013042	Putative cation transport regulator [General function prediction only]; Region: ChaB; COG4572
103690013043	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690013044	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690013045	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690013046	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
103690013047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690013048	motif II; other site
103690013049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690013050	active site
103690013051	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690013052	phosphorylation site [posttranslational modification]
103690013053	intermolecular recognition site; other site
103690013054	dimerization interface [polypeptide binding]; other site
103690013055	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690013056	dimer interface [polypeptide binding]; other site
103690013057	phosphorylation site [posttranslational modification]
103690013058	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690013059	ATP binding site [chemical binding]; other site
103690013060	Mg2+ binding site [ion binding]; other site
103690013061	G-X-G motif; other site
103690013062	Response regulator receiver domain; Region: Response_reg; pfam00072
103690013063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690013064	active site
103690013065	phosphorylation site [posttranslational modification]
103690013066	intermolecular recognition site; other site
103690013067	dimerization interface [polypeptide binding]; other site
103690013068	PAS domain S-box; Region: sensory_box; TIGR00229
103690013069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690013070	putative active site [active]
103690013071	heme pocket [chemical binding]; other site
103690013072	PAS fold; Region: PAS_3; pfam08447
103690013073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690013074	putative active site [active]
103690013075	heme pocket [chemical binding]; other site
103690013076	PAS domain S-box; Region: sensory_box; TIGR00229
103690013077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690013078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690013079	dimer interface [polypeptide binding]; other site
103690013080	phosphorylation site [posttranslational modification]
103690013081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690013082	ATP binding site [chemical binding]; other site
103690013083	Mg2+ binding site [ion binding]; other site
103690013084	G-X-G motif; other site
103690013085	Response regulator receiver domain; Region: Response_reg; pfam00072
103690013086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690013087	active site
103690013088	phosphorylation site [posttranslational modification]
103690013089	intermolecular recognition site; other site
103690013090	dimerization interface [polypeptide binding]; other site
103690013091	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690013092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690013093	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
103690013094	dimerization interface [polypeptide binding]; other site
103690013095	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
103690013096	Repair protein; Region: Repair_PSII; pfam04536
103690013097	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
103690013098	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
103690013099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
103690013100	Protein of unknown function, DUF482; Region: DUF482; pfam04339
103690013101	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
103690013102	RibD C-terminal domain; Region: RibD_C; cl17279
103690013103	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690013104	Probable transposase; Region: OrfB_IS605; pfam01385
103690013105	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690013106	HAMP domain; Region: HAMP; pfam00672
103690013107	dimerization interface [polypeptide binding]; other site
103690013108	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690013109	dimer interface [polypeptide binding]; other site
103690013110	phosphorylation site [posttranslational modification]
103690013111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690013112	ATP binding site [chemical binding]; other site
103690013113	Mg2+ binding site [ion binding]; other site
103690013114	G-X-G motif; other site
103690013115	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
103690013116	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
103690013117	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
103690013118	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
103690013119	dimerization interface [polypeptide binding]; other site
103690013120	active site
103690013121	metal binding site [ion binding]; metal-binding site
103690013122	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
103690013123	dsRNA binding site [nucleotide binding]; other site
103690013124	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
103690013125	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
103690013126	oligomer interface [polypeptide binding]; other site
103690013127	metal binding site [ion binding]; metal-binding site
103690013128	metal binding site [ion binding]; metal-binding site
103690013129	Cl binding site [ion binding]; other site
103690013130	aspartate ring; other site
103690013131	basic sphincter; other site
103690013132	putative hydrophobic gate; other site
103690013133	periplasmic entrance; other site
103690013134	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
103690013135	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
103690013136	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690013137	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690013138	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
103690013139	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
103690013140	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
103690013141	D-alanyl-D-alanine dipeptidase [Cell envelope biogenesis, outer membrane]; Region: DdpX; COG2173
103690013142	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
103690013143	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
103690013144	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
103690013145	homoserine dehydrogenase; Provisional; Region: PRK06349
103690013146	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
103690013147	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
103690013148	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
103690013149	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
103690013150	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
103690013151	dimerization interface [polypeptide binding]; other site
103690013152	FAD binding pocket [chemical binding]; other site
103690013153	FAD binding motif [chemical binding]; other site
103690013154	catalytic residues [active]
103690013155	NAD binding pocket [chemical binding]; other site
103690013156	phosphate binding motif [ion binding]; other site
103690013157	beta-alpha-beta structure motif; other site
103690013158	phosphoribulokinase; Provisional; Region: PRK07429
103690013159	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
103690013160	active site
103690013161	S-adenosylmethionine synthetase; Validated; Region: PRK05250
103690013162	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
103690013163	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
103690013164	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
103690013165	Predicted membrane protein [Function unknown]; Region: COG5305
103690013166	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
103690013167	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
103690013168	Ligand binding site; other site
103690013169	Putative Catalytic site; other site
103690013170	DXD motif; other site
103690013171	Predicted membrane protein [Function unknown]; Region: COG2246
103690013172	GtrA-like protein; Region: GtrA; pfam04138
103690013173	Predicted membrane protein [Function unknown]; Region: COG5305
103690013174	FO synthase subunit 2; Reviewed; Region: PRK07360
103690013175	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690013176	FeS/SAM binding site; other site
103690013177	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
103690013178	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690013179	substrate binding pocket [chemical binding]; other site
103690013180	membrane-bound complex binding site; other site
103690013181	hinge residues; other site
103690013182	Phosphoglycerate kinase; Region: PGK; pfam00162
103690013183	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
103690013184	substrate binding site [chemical binding]; other site
103690013185	hinge regions; other site
103690013186	ADP binding site [chemical binding]; other site
103690013187	catalytic site [active]
103690013188	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690013189	Ligand Binding Site [chemical binding]; other site
103690013190	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690013191	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
103690013192	putative active site [active]
103690013193	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
103690013194	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
103690013195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2929
103690013196	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
103690013197	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
103690013198	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
103690013199	G1 box; other site
103690013200	putative GEF interaction site [polypeptide binding]; other site
103690013201	GTP/Mg2+ binding site [chemical binding]; other site
103690013202	Switch I region; other site
103690013203	G2 box; other site
103690013204	G3 box; other site
103690013205	Switch II region; other site
103690013206	G4 box; other site
103690013207	G5 box; other site
103690013208	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
103690013209	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
103690013210	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690013211	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690013212	active site
103690013213	ATP binding site [chemical binding]; other site
103690013214	substrate binding site [chemical binding]; other site
103690013215	activation loop (A-loop); other site
103690013216	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690013217	putative active site [active]
103690013218	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690013219	putative active site [active]
103690013220	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
103690013221	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
103690013222	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
103690013223	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
103690013224	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
103690013225	dimerization interface [polypeptide binding]; other site
103690013226	DPS ferroxidase diiron center [ion binding]; other site
103690013227	ion pore; other site
103690013228	Uncharacterized protein, contains ParB-like nuclease domain [General function prediction only]; Region: COG5119
103690013229	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
103690013230	Stage II sporulation protein; Region: SpoIID; pfam08486
103690013231	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
103690013232	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
103690013233	catalytic loop [active]
103690013234	iron binding site [ion binding]; other site
103690013235	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
103690013236	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
103690013237	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
103690013238	active site
103690013239	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
103690013240	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690013241	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013242	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013243	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
103690013244	SpoOM protein; Region: Spo0M; pfam07070
103690013245	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
103690013246	Uncharacterized conserved protein [Function unknown]; Region: COG4279
103690013247	SWIM zinc finger; Region: SWIM; pfam04434
103690013248	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
103690013249	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
103690013250	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690013251	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
103690013252	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690013253	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
103690013254	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
103690013255	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690013256	anti sigma factor interaction site; other site
103690013257	regulatory phosphorylation site [posttranslational modification]; other site
103690013258	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
103690013259	Bacterial sugar transferase; Region: Bac_transf; pfam02397
103690013260	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
103690013261	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690013262	FeS/SAM binding site; other site
103690013263	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
103690013264	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
103690013265	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
103690013266	substrate binding pocket [chemical binding]; other site
103690013267	membrane-bound complex binding site; other site
103690013268	hinge residues; other site
103690013269	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
103690013270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690013271	dimer interface [polypeptide binding]; other site
103690013272	conserved gate region; other site
103690013273	putative PBP binding loops; other site
103690013274	ABC-ATPase subunit interface; other site
103690013275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690013276	dimer interface [polypeptide binding]; other site
103690013277	conserved gate region; other site
103690013278	putative PBP binding loops; other site
103690013279	ABC-ATPase subunit interface; other site
103690013280	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
103690013281	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
103690013282	Walker A/P-loop; other site
103690013283	ATP binding site [chemical binding]; other site
103690013284	Q-loop/lid; other site
103690013285	ABC transporter signature motif; other site
103690013286	Walker B; other site
103690013287	D-loop; other site
103690013288	H-loop/switch region; other site
103690013289	putative glycosyl transferase; Provisional; Region: PRK10307
103690013290	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
103690013291	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
103690013292	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
103690013293	L-asparaginase II [Amino acid transport and metabolism]; Region: AnsA; COG4448
103690013294	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690013295	G1 box; other site
103690013296	GTP/Mg2+ binding site [chemical binding]; other site
103690013297	Switch I region; other site
103690013298	G3 box; other site
103690013299	Switch II region; other site
103690013300	G4 box; other site
103690013301	G5 box; other site
103690013302	Domain of unknown function (DUF697); Region: DUF697; pfam05128
103690013303	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690013304	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690013305	cofactor binding site; other site
103690013306	DNA binding site [nucleotide binding]
103690013307	substrate interaction site [chemical binding]; other site
103690013308	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690013309	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
103690013310	intersubunit interface [polypeptide binding]; other site
103690013311	active site
103690013312	catalytic residue [active]
103690013313	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
103690013314	Recombination protein O N terminal; Region: RecO_N; pfam11967
103690013315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690013316	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690013317	putative substrate translocation pore; other site
103690013318	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690013319	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690013320	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690013321	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690013322	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690013323	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
103690013324	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
103690013325	active site
103690013326	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
103690013327	phosphoglyceromutase; Provisional; Region: PRK05434
103690013328	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
103690013329	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
103690013330	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
103690013331	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
103690013332	ABC transporter; Region: ABC_tran_2; pfam12848
103690013333	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
103690013334	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690013335	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690013336	peptide chain release factor 1; Validated; Region: prfA; PRK00591
103690013337	This domain is found in peptide chain release factors; Region: PCRF; smart00937
103690013338	RF-1 domain; Region: RF-1; pfam00472
103690013339	ribosomal protein L31; Validated; Region: rpl31; CHL00136
103690013340	ribosomal protein S9; Region: rps9; CHL00079
103690013341	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
103690013342	23S rRNA interface [nucleotide binding]; other site
103690013343	L3 interface [polypeptide binding]; other site
103690013344	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
103690013345	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
103690013346	dimerization interface 3.5A [polypeptide binding]; other site
103690013347	active site
103690013348	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
103690013349	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
103690013350	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
103690013351	alphaNTD - beta interaction site [polypeptide binding]; other site
103690013352	alphaNTD homodimer interface [polypeptide binding]; other site
103690013353	alphaNTD - beta' interaction site [polypeptide binding]; other site
103690013354	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
103690013355	30S ribosomal protein S11; Validated; Region: PRK05309
103690013356	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
103690013357	30S ribosomal protein S13; Region: bact_S13; TIGR03631
103690013358	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
103690013359	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
103690013360	rRNA binding site [nucleotide binding]; other site
103690013361	predicted 30S ribosome binding site; other site
103690013362	adenylate kinase; Provisional; Region: adk; PRK02496
103690013363	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
103690013364	AMP-binding site [chemical binding]; other site
103690013365	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
103690013366	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
103690013367	SecY translocase; Region: SecY; pfam00344
103690013368	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
103690013369	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
103690013370	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
103690013371	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
103690013372	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
103690013373	5S rRNA interface [nucleotide binding]; other site
103690013374	23S rRNA interface [nucleotide binding]; other site
103690013375	L5 interface [polypeptide binding]; other site
103690013376	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
103690013377	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
103690013378	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
103690013379	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
103690013380	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
103690013381	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
103690013382	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
103690013383	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
103690013384	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
103690013385	RNA binding site [nucleotide binding]; other site
103690013386	ribosomal protein L14; Region: rpl14; CHL00057
103690013387	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
103690013388	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
103690013389	23S rRNA interface [nucleotide binding]; other site
103690013390	putative translocon interaction site; other site
103690013391	signal recognition particle (SRP54) interaction site; other site
103690013392	L23 interface [polypeptide binding]; other site
103690013393	trigger factor interaction site; other site
103690013394	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
103690013395	23S rRNA interface [nucleotide binding]; other site
103690013396	5S rRNA interface [nucleotide binding]; other site
103690013397	putative antibiotic binding site [chemical binding]; other site
103690013398	L25 interface [polypeptide binding]; other site
103690013399	L27 interface [polypeptide binding]; other site
103690013400	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
103690013401	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
103690013402	G-X-X-G motif; other site
103690013403	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
103690013404	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
103690013405	putative translocon binding site; other site
103690013406	protein-rRNA interface [nucleotide binding]; other site
103690013407	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
103690013408	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
103690013409	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
103690013410	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
103690013411	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
103690013412	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
103690013413	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
103690013414	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
103690013415	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
103690013416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690013417	Coenzyme A binding pocket [chemical binding]; other site
103690013418	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
103690013419	ABC-2 type transporter; Region: ABC2_membrane; cl17235
103690013420	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690013421	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013422	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013423	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690013424	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690013425	PGAP1-like protein; Region: PGAP1; pfam07819
103690013426	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
103690013427	hypothetical protein; Provisional; Region: PRK05421
103690013428	putative catalytic site [active]
103690013429	putative metal binding site [ion binding]; other site
103690013430	putative phosphate binding site [ion binding]; other site
103690013431	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
103690013432	Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155
103690013433	putative active site [active]
103690013434	catalytic site [active]
103690013435	Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161
103690013436	putative active site [active]
103690013437	catalytic site [active]
103690013438	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690013439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690013440	metal binding site [ion binding]; metal-binding site
103690013441	active site
103690013442	I-site; other site
103690013443	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690013444	Predicted membrane protein [Function unknown]; Region: COG5346
103690013445	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690013446	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690013447	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690013448	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690013449	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3228
103690013450	threonine dehydratase; Reviewed; Region: PRK09224
103690013451	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
103690013452	tetramer interface [polypeptide binding]; other site
103690013453	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690013454	catalytic residue [active]
103690013455	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
103690013456	putative Ile/Val binding site [chemical binding]; other site
103690013457	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
103690013458	putative Ile/Val binding site [chemical binding]; other site
103690013459	stage V sporulation protein K; Region: spore_V_K; TIGR02881
103690013460	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690013461	Walker A motif; other site
103690013462	ATP binding site [chemical binding]; other site
103690013463	Walker B motif; other site
103690013464	arginine finger; other site
103690013465	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
103690013466	heterotetramer interface [polypeptide binding]; other site
103690013467	active site pocket [active]
103690013468	cleavage site
103690013469	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
103690013470	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
103690013471	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
103690013472	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247
103690013473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
103690013474	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690013475	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690013476	ligand binding site [chemical binding]; other site
103690013477	flexible hinge region; other site
103690013478	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690013479	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
103690013480	putative active site [active]
103690013481	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690013482	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690013483	Walker A/P-loop; other site
103690013484	ATP binding site [chemical binding]; other site
103690013485	Q-loop/lid; other site
103690013486	ABC transporter signature motif; other site
103690013487	Walker B; other site
103690013488	D-loop; other site
103690013489	H-loop/switch region; other site
103690013490	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690013491	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
103690013492	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690013493	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
103690013494	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
103690013495	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
103690013496	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
103690013497	Ligand Binding Site [chemical binding]; other site
103690013498	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
103690013499	F subunit of K+-transporting ATPase (Potass_KdpF); Region: Potass_KdpF; pfam09604
103690013500	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
103690013501	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
103690013502	Soluble P-type ATPase [General function prediction only]; Region: COG4087
103690013503	K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; COG2060
103690013504	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690013505	hypothetical protein; Provisional; Region: PRK06753
103690013506	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
103690013507	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690013508	ATP binding site [chemical binding]; other site
103690013509	putative Mg++ binding site [ion binding]; other site
103690013510	helicase superfamily c-terminal domain; Region: HELICc; smart00490
103690013511	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690013512	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
103690013513	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690013514	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690013515	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690013516	DNA binding residues [nucleotide binding]
103690013517	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690013518	Coenzyme A binding pocket [chemical binding]; other site
103690013519	cytochrome c6; Provisional; Region: PRK13697
103690013520	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
103690013521	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
103690013522	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
103690013523	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
103690013524	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
103690013525	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
103690013526	NAD(P) binding site [chemical binding]; other site
103690013527	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
103690013528	CoA binding site [chemical binding]; other site
103690013529	acetyl-CoA synthetase; Provisional; Region: PRK00174
103690013530	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
103690013531	acyl-activating enzyme (AAE) consensus motif; other site
103690013532	active site
103690013533	AMP binding site [chemical binding]; other site
103690013534	CoA binding site [chemical binding]; other site
103690013535	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690013536	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690013537	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690013538	GAF domain; Region: GAF; pfam01590
103690013539	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690013540	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690013541	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690013542	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690013543	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690013544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690013545	ATP binding site [chemical binding]; other site
103690013546	Mg2+ binding site [ion binding]; other site
103690013547	G-X-G motif; other site
103690013548	PetN; Region: PetN; pfam03742
103690013549	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
103690013550	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
103690013551	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
103690013552	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
103690013553	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
103690013554	putative NADP binding site [chemical binding]; other site
103690013555	putative substrate binding site [chemical binding]; other site
103690013556	active site
103690013557	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
103690013558	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690013559	FeS/SAM binding site; other site
103690013560	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
103690013561	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
103690013562	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
103690013563	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
103690013564	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
103690013565	quinone interaction residues [chemical binding]; other site
103690013566	active site
103690013567	catalytic residues [active]
103690013568	FMN binding site [chemical binding]; other site
103690013569	substrate binding site [chemical binding]; other site
103690013570	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690013571	GAF domain; Region: GAF; pfam01590
103690013572	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
103690013573	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
103690013574	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690013575	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690013576	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690013577	hypothetical protein; Validated; Region: PRK00110
103690013578	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
103690013579	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
103690013580	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
103690013581	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
103690013582	putative active site [active]
103690013583	putative metal binding site [ion binding]; other site
103690013584	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690013585	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690013586	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690013587	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690013588	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690013589	DevC protein; Region: devC; TIGR01185
103690013590	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690013591	FtsX-like permease family; Region: FtsX; pfam02687
103690013592	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
103690013593	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690013594	Walker A/P-loop; other site
103690013595	ATP binding site [chemical binding]; other site
103690013596	Q-loop/lid; other site
103690013597	ABC transporter signature motif; other site
103690013598	Walker B; other site
103690013599	D-loop; other site
103690013600	H-loop/switch region; other site
103690013601	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
103690013602	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
103690013603	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
103690013604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690013605	BT1 family; Region: BT1; pfam03092
103690013606	putative substrate translocation pore; other site
103690013607	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
103690013608	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
103690013609	dimer interface [polypeptide binding]; other site
103690013610	active site
103690013611	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
103690013612	active site
103690013613	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
103690013614	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
103690013615	D1 interface; other site
103690013616	chlorophyll binding site; other site
103690013617	pheophytin binding site; other site
103690013618	beta carotene binding site; other site
103690013619	cytochrome b559 beta interface; other site
103690013620	quinone binding site; other site
103690013621	cytochrome b559 alpha interface; other site
103690013622	protein J interface; other site
103690013623	protein H interface; other site
103690013624	protein X interface; other site
103690013625	core light harvesting protein interface; other site
103690013626	protein L interface; other site
103690013627	CP43 interface; other site
103690013628	protein T interface; other site
103690013629	Fe binding site [ion binding]; other site
103690013630	protein M interface; other site
103690013631	Mn-stabilizing polypeptide interface; other site
103690013632	bromide binding site; other site
103690013633	cytochrome c-550 interface; other site
103690013634	photosystem II 44 kDa protein; Region: psbC; CHL00035
103690013635	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
103690013636	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
103690013637	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690013638	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690013639	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690013640	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690013641	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690013642	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690013643	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690013644	Ycf46; Provisional; Region: ycf46; CHL00195
103690013645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690013646	Walker A motif; other site
103690013647	ATP binding site [chemical binding]; other site
103690013648	Walker B motif; other site
103690013649	arginine finger; other site
103690013650	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
103690013651	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
103690013652	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690013653	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690013654	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013655	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690013656	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013657	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013658	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690013659	Predicted sensor protein/domain [Signal transduction mechanisms]; Region: COG4250
103690013660	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
103690013661	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
103690013662	Zn2+ binding site [ion binding]; other site
103690013663	Mg2+ binding site [ion binding]; other site
103690013664	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
103690013665	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
103690013666	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
103690013667	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690013668	FeS/SAM binding site; other site
103690013669	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
103690013670	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
103690013671	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
103690013672	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
103690013673	Walker A/P-loop; other site
103690013674	ATP binding site [chemical binding]; other site
103690013675	Q-loop/lid; other site
103690013676	ABC transporter signature motif; other site
103690013677	Walker B; other site
103690013678	D-loop; other site
103690013679	H-loop/switch region; other site
103690013680	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690013681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690013682	active site
103690013683	phosphorylation site [posttranslational modification]
103690013684	intermolecular recognition site; other site
103690013685	dimerization interface [polypeptide binding]; other site
103690013686	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690013687	DNA binding site [nucleotide binding]
103690013688	Predicted membrane protein [Function unknown]; Region: COG3650
103690013689	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
103690013690	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
103690013691	Mg++ binding site [ion binding]; other site
103690013692	putative catalytic motif [active]
103690013693	putative substrate binding site [chemical binding]; other site
103690013694	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
103690013695	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
103690013696	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
103690013697	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
103690013698	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
103690013699	DNA binding site [nucleotide binding]
103690013700	catalytic residue [active]
103690013701	H2TH interface [polypeptide binding]; other site
103690013702	putative catalytic residues [active]
103690013703	turnover-facilitating residue; other site
103690013704	intercalation triad [nucleotide binding]; other site
103690013705	8OG recognition residue [nucleotide binding]; other site
103690013706	putative reading head residues; other site
103690013707	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
103690013708	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
103690013709	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
103690013710	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
103690013711	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
103690013712	NAD(P) binding site [chemical binding]; other site
103690013713	dimer interface [polypeptide binding]; other site
103690013714	tetramer (dimer of dimers) interface [polypeptide binding]; other site
103690013715	substrate binding site [chemical binding]; other site
103690013716	Core-2/I-Branching enzyme; Region: Branch; pfam02485
103690013717	CAAX protease self-immunity; Region: Abi; pfam02517
103690013718	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
103690013719	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
103690013720	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690013721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690013722	homodimer interface [polypeptide binding]; other site
103690013723	catalytic residue [active]
103690013724	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690013725	anti sigma factor interaction site; other site
103690013726	regulatory phosphorylation site [posttranslational modification]; other site
103690013727	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
103690013728	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
103690013729	B12 binding site [chemical binding]; other site
103690013730	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690013731	FeS/SAM binding site; other site
103690013732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011
103690013733	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
103690013734	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
103690013735	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
103690013736	homodimer interface [polypeptide binding]; other site
103690013737	oligonucleotide binding site [chemical binding]; other site
103690013738	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
103690013739	RNA/DNA hybrid binding site [nucleotide binding]; other site
103690013740	active site
103690013741	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
103690013742	prephenate dehydratase; Provisional; Region: PRK11898
103690013743	Prephenate dehydratase; Region: PDT; pfam00800
103690013744	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
103690013745	putative L-Phe binding site [chemical binding]; other site
103690013746	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
103690013747	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
103690013748	elongation factor Tu; Region: tufA; CHL00071
103690013749	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
103690013750	G1 box; other site
103690013751	GEF interaction site [polypeptide binding]; other site
103690013752	GTP/Mg2+ binding site [chemical binding]; other site
103690013753	Switch I region; other site
103690013754	G2 box; other site
103690013755	G3 box; other site
103690013756	Switch II region; other site
103690013757	G4 box; other site
103690013758	G5 box; other site
103690013759	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
103690013760	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
103690013761	Antibiotic Binding Site [chemical binding]; other site
103690013762	elongation factor G; Reviewed; Region: PRK00007
103690013763	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
103690013764	G1 box; other site
103690013765	putative GEF interaction site [polypeptide binding]; other site
103690013766	GTP/Mg2+ binding site [chemical binding]; other site
103690013767	Switch I region; other site
103690013768	G2 box; other site
103690013769	G3 box; other site
103690013770	Switch II region; other site
103690013771	G4 box; other site
103690013772	G5 box; other site
103690013773	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
103690013774	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
103690013775	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
103690013776	30S ribosomal protein S7; Validated; Region: PRK05302
103690013777	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
103690013778	S17 interaction site [polypeptide binding]; other site
103690013779	S8 interaction site; other site
103690013780	16S rRNA interaction site [nucleotide binding]; other site
103690013781	streptomycin interaction site [chemical binding]; other site
103690013782	23S rRNA interaction site [nucleotide binding]; other site
103690013783	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
103690013784	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
103690013785	Cupin domain; Region: Cupin_2; cl17218
103690013786	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
103690013787	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
103690013788	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
103690013789	active site
103690013790	dimer interface [polypeptide binding]; other site
103690013791	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
103690013792	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
103690013793	active site
103690013794	FMN binding site [chemical binding]; other site
103690013795	substrate binding site [chemical binding]; other site
103690013796	3Fe-4S cluster binding site [ion binding]; other site
103690013797	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
103690013798	domain interface; other site
103690013799	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
103690013800	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
103690013801	NodB motif; other site
103690013802	active site
103690013803	catalytic site [active]
103690013804	metal binding site [ion binding]; metal-binding site
103690013805	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
103690013806	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
103690013807	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
103690013808	Predicted integral membrane protein [Function unknown]; Region: COG5542
103690013809	Predicted integral membrane protein [Function unknown]; Region: COG5542
103690013810	Predicted integral membrane protein [Function unknown]; Region: COG5542
103690013811	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
103690013812	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
103690013813	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
103690013814	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
103690013815	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
103690013816	MoaE interaction surface [polypeptide binding]; other site
103690013817	MoeB interaction surface [polypeptide binding]; other site
103690013818	thiocarboxylated glycine; other site
103690013819	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
103690013820	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
103690013821	iron-sulfur cluster [ion binding]; other site
103690013822	[2Fe-2S] cluster binding site [ion binding]; other site
103690013823	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
103690013824	Pheophorbide a oxygenase; Region: PaO; pfam08417
103690013825	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690013826	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
103690013827	HSP70 interaction site [polypeptide binding]; other site
103690013828	Clp protease; Region: CLP_protease; pfam00574
103690013829	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
103690013830	oligomer interface [polypeptide binding]; other site
103690013831	active site residues [active]
103690013832	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
103690013833	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
103690013834	oligomer interface [polypeptide binding]; other site
103690013835	active site residues [active]
103690013836	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
103690013837	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
103690013838	metal ion-dependent adhesion site (MIDAS); other site
103690013839	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
103690013840	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
103690013841	metal ion-dependent adhesion site (MIDAS); other site
103690013842	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
103690013843	YcfA-like protein; Region: YcfA; cl00752
103690013844	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
103690013845	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690013846	putative active site [active]
103690013847	magnesium chelatase subunit H; Provisional; Region: PRK12493
103690013848	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
103690013849	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
103690013850	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690013851	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690013852	active site
103690013853	ATP binding site [chemical binding]; other site
103690013854	substrate binding site [chemical binding]; other site
103690013855	activation loop (A-loop); other site
103690013856	Translocated intimin receptor (Tir) C-terminus; Region: Tir_receptor_C; pfam07489
103690013857	short chain dehydrogenase; Provisional; Region: PRK08265
103690013858	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690013859	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690013860	active site
103690013861	ATP binding site [chemical binding]; other site
103690013862	substrate binding site [chemical binding]; other site
103690013863	activation loop (A-loop); other site
103690013864	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
103690013865	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
103690013866	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
103690013867	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
103690013868	active site
103690013869	metal binding site [ion binding]; metal-binding site
103690013870	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
103690013871	Peptidase family M48; Region: Peptidase_M48; pfam01435
103690013872	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
103690013873	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
103690013874	Domain of unknown function (DUF814); Region: DUF814; pfam05670
103690013875	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
103690013876	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
103690013877	putative ADP-binding pocket [chemical binding]; other site
103690013878	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690013879	RNA recognition motif; Region: RRM; smart00360
103690013880	Tetratricopeptide repeat; Region: TPR_16; pfam13432
103690013881	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
103690013882	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
103690013883	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
103690013884	G1 box; other site
103690013885	putative GEF interaction site [polypeptide binding]; other site
103690013886	GTP/Mg2+ binding site [chemical binding]; other site
103690013887	Switch I region; other site
103690013888	G2 box; other site
103690013889	G3 box; other site
103690013890	Switch II region; other site
103690013891	G4 box; other site
103690013892	G5 box; other site
103690013893	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
103690013894	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
103690013895	dimer interface [polypeptide binding]; other site
103690013896	active site
103690013897	Schiff base residues; other site
103690013898	Predicted membrane protein [Function unknown]; Region: COG3431
103690013899	TPR repeat; Region: TPR_11; pfam13414
103690013900	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690013901	binding surface
103690013902	TPR motif; other site
103690013903	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690013904	binding surface
103690013905	TPR repeat; Region: TPR_11; pfam13414
103690013906	TPR motif; other site
103690013907	TPR repeat; Region: TPR_11; pfam13414
103690013908	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
103690013909	elongation factor G; Reviewed; Region: PRK12740
103690013910	G1 box; other site
103690013911	putative GEF interaction site [polypeptide binding]; other site
103690013912	GTP/Mg2+ binding site [chemical binding]; other site
103690013913	Switch I region; other site
103690013914	G2 box; other site
103690013915	G3 box; other site
103690013916	Switch II region; other site
103690013917	G4 box; other site
103690013918	G5 box; other site
103690013919	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
103690013920	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
103690013921	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
103690013922	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
103690013923	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
103690013924	G1 box; other site
103690013925	GTP/Mg2+ binding site [chemical binding]; other site
103690013926	Switch I region; other site
103690013927	G2 box; other site
103690013928	Switch II region; other site
103690013929	G3 box; other site
103690013930	G4 box; other site
103690013931	G5 box; other site
103690013932	Domain of unknown function (DUF697); Region: DUF697; pfam05128
103690013933	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
103690013934	triosephosphate isomerase; Provisional; Region: PRK14565
103690013935	substrate binding site [chemical binding]; other site
103690013936	dimer interface [polypeptide binding]; other site
103690013937	catalytic triad [active]
103690013938	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
103690013939	dihydropteroate synthase; Region: DHPS; TIGR01496
103690013940	substrate binding pocket [chemical binding]; other site
103690013941	dimer interface [polypeptide binding]; other site
103690013942	inhibitor binding site; inhibition site
103690013943	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
103690013944	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
103690013945	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
103690013946	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
103690013947	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
103690013948	SLBB domain; Region: SLBB; pfam10531
103690013949	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690013950	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
103690013951	Walker A/P-loop; other site
103690013952	ATP binding site [chemical binding]; other site
103690013953	Q-loop/lid; other site
103690013954	ABC transporter signature motif; other site
103690013955	Walker B; other site
103690013956	D-loop; other site
103690013957	H-loop/switch region; other site
103690013958	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
103690013959	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
103690013960	putative active site pocket [active]
103690013961	4-fold oligomerization interface [polypeptide binding]; other site
103690013962	metal binding residues [ion binding]; metal-binding site
103690013963	3-fold/trimer interface [polypeptide binding]; other site
103690013964	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
103690013965	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
103690013966	NAD binding site [chemical binding]; other site
103690013967	homotetramer interface [polypeptide binding]; other site
103690013968	homodimer interface [polypeptide binding]; other site
103690013969	substrate binding site [chemical binding]; other site
103690013970	active site
103690013971	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690013972	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
103690013973	ligand binding site [chemical binding]; other site
103690013974	flexible hinge region; other site
103690013975	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
103690013976	putative switch regulator; other site
103690013977	non-specific DNA interactions [nucleotide binding]; other site
103690013978	DNA binding site [nucleotide binding]
103690013979	sequence specific DNA binding site [nucleotide binding]; other site
103690013980	putative cAMP binding site [chemical binding]; other site
103690013981	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
103690013982	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
103690013983	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
103690013984	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
103690013985	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
103690013986	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
103690013987	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
103690013988	RNase E interface [polypeptide binding]; other site
103690013989	trimer interface [polypeptide binding]; other site
103690013990	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
103690013991	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
103690013992	RNase E interface [polypeptide binding]; other site
103690013993	trimer interface [polypeptide binding]; other site
103690013994	active site
103690013995	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
103690013996	putative nucleic acid binding region [nucleotide binding]; other site
103690013997	G-X-X-G motif; other site
103690013998	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
103690013999	RNA binding site [nucleotide binding]; other site
103690014000	domain interface; other site
103690014001	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690014002	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690014003	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
103690014004	SNF2 Helicase protein; Region: DUF3670; pfam12419
103690014005	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690014006	ATP binding site [chemical binding]; other site
103690014007	putative Mg++ binding site [ion binding]; other site
103690014008	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690014009	nucleotide binding region [chemical binding]; other site
103690014010	ATP-binding site [chemical binding]; other site
103690014011	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690014012	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690014013	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690014014	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
103690014015	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
103690014016	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
103690014017	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
103690014018	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
103690014019	metal ion-dependent adhesion site (MIDAS); other site
103690014020	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
103690014021	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
103690014022	dimer interface [polypeptide binding]; other site
103690014023	decamer (pentamer of dimers) interface [polypeptide binding]; other site
103690014024	catalytic triad [active]
103690014025	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690014026	putative active site [active]
103690014027	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
103690014028	putative methyltransferase; Provisional; Region: PRK11524
103690014029	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
103690014030	Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699
103690014031	marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788
103690014032	vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to...; Region: vWA_interalpha_trypsin_inhibitor; cd01461
103690014033	metal ion-dependent adhesion site (MIDAS); other site
103690014034	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
103690014035	Dynamin family; Region: Dynamin_N; pfam00350
103690014036	G1 box; other site
103690014037	GTP/Mg2+ binding site [chemical binding]; other site
103690014038	G2 box; other site
103690014039	Switch I region; other site
103690014040	G3 box; other site
103690014041	Switch II region; other site
103690014042	G4 box; other site
103690014043	G5 box; other site
103690014044	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690014045	HSP70 interaction site [polypeptide binding]; other site
103690014046	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690014047	Dynamin family; Region: Dynamin_N; pfam00350
103690014048	G1 box; other site
103690014049	GTP/Mg2+ binding site [chemical binding]; other site
103690014050	G2 box; other site
103690014051	Switch I region; other site
103690014052	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
103690014053	G3 box; other site
103690014054	Switch II region; other site
103690014055	GTP/Mg2+ binding site [chemical binding]; other site
103690014056	G4 box; other site
103690014057	G5 box; other site
103690014058	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
103690014059	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
103690014060	dimer interface [polypeptide binding]; other site
103690014061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690014062	catalytic residue [active]
103690014063	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
103690014064	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
103690014065	active site
103690014066	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690014067	active site
103690014068	phosphorylation site [posttranslational modification]
103690014069	intermolecular recognition site; other site
103690014070	dimerization interface [polypeptide binding]; other site
103690014071	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
103690014072	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
103690014073	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
103690014074	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
103690014075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014076	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690014077	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690014078	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690014079	active site
103690014080	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014081	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
103690014082	Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5285
103690014083	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
103690014084	O-Antigen ligase; Region: Wzy_C; pfam04932
103690014085	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
103690014086	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
103690014087	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690014088	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
103690014089	active site
103690014090	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690014091	Chain length determinant protein; Region: Wzz; pfam02706
103690014092	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
103690014093	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690014094	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690014095	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690014096	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690014097	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
103690014098	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690014099	Double zinc ribbon; Region: DZR; pfam12773
103690014100	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
103690014101	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014102	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
103690014103	putative ADP-binding pocket [chemical binding]; other site
103690014104	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014105	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690014106	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690014107	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690014108	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690014109	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690014110	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690014111	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690014112	active site
103690014113	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
103690014114	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
103690014115	FAD binding domain; Region: FAD_binding_4; pfam01565
103690014116	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690014117	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690014118	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
103690014119	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690014120	Predicted membrane protein [Function unknown]; Region: COG3431
103690014121	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
103690014122	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
103690014123	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
103690014124	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
103690014125	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
103690014126	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
103690014127	catalytic residue [active]
103690014128	Beta-1,4-xylanase [Carbohydrate transport and metabolism]; Region: XynA; COG3693
103690014129	Exoribonuclease R [Transcription]; Region: VacB; COG0557
103690014130	RNB domain; Region: RNB; pfam00773
103690014131	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
103690014132	ribosomal protein L33; Region: rpl33; CHL00104
103690014133	RDD family; Region: RDD; pfam06271
103690014134	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690014135	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690014136	ligand binding site [chemical binding]; other site
103690014137	flexible hinge region; other site
103690014138	putative switch regulator; other site
103690014139	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
103690014140	non-specific DNA interactions [nucleotide binding]; other site
103690014141	DNA binding site [nucleotide binding]
103690014142	sequence specific DNA binding site [nucleotide binding]; other site
103690014143	putative cAMP binding site [chemical binding]; other site
103690014144	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
103690014145	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
103690014146	substrate binding site [chemical binding]; other site
103690014147	oxyanion hole (OAH) forming residues; other site
103690014148	trimer interface [polypeptide binding]; other site
103690014149	tropinone reductase; Provisional; Region: PRK09242
103690014150	tropinone reductase-I and II (TR-1, and TR-II)-like, classical (c) SDRs; Region: TR_SDR_c; cd05329
103690014151	NADP binding site [chemical binding]; other site
103690014152	homodimer interface [polypeptide binding]; other site
103690014153	substrate binding site [chemical binding]; other site
103690014154	active site
103690014155	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
103690014156	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
103690014157	putative NAD(P) binding site [chemical binding]; other site
103690014158	catalytic Zn binding site [ion binding]; other site
103690014159	structural Zn binding site [ion binding]; other site
103690014160	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
103690014161	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
103690014162	active site
103690014163	PUCC protein; Region: PUCC; pfam03209
103690014164	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
103690014165	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
103690014166	active site
103690014167	metal binding site [ion binding]; metal-binding site
103690014168	DNA binding site [nucleotide binding]
103690014169	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
103690014170	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
103690014171	Active Sites [active]
103690014172	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690014173	Probable transposase; Region: OrfB_IS605; pfam01385
103690014174	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690014175	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
103690014176	ATP adenylyltransferase; Region: ATP_transf; pfam09830
103690014177	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
103690014178	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690014179	Coenzyme A binding pocket [chemical binding]; other site
103690014180	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
103690014181	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690014182	putative metal binding site [ion binding]; other site
103690014183	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
103690014184	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
103690014185	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
103690014186	dimer interface [polypeptide binding]; other site
103690014187	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
103690014188	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
103690014189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690014190	binding surface
103690014191	TPR motif; other site
103690014192	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
103690014193	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
103690014194	putative NEF/HSP70 interaction site [polypeptide binding]; other site
103690014195	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
103690014196	nucleotide binding site [chemical binding]; other site
103690014197	SBD interface [polypeptide binding]; other site
103690014198	Predicted membrane protein [Function unknown]; Region: COG4270
103690014199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4446
103690014200	chlorophyll synthase, ChlG; Region: ChlG; TIGR02056
103690014201	UbiA prenyltransferase family; Region: UbiA; pfam01040
103690014202	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
103690014203	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
103690014204	P loop; other site
103690014205	Nucleotide binding site [chemical binding]; other site
103690014206	DTAP/Switch II; other site
103690014207	Switch I; other site
103690014208	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
103690014209	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690014210	putative active site [active]
103690014211	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
103690014212	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
103690014213	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
103690014214	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
103690014215	Walker A/P-loop; other site
103690014216	ATP binding site [chemical binding]; other site
103690014217	Q-loop/lid; other site
103690014218	ABC transporter signature motif; other site
103690014219	Walker B; other site
103690014220	D-loop; other site
103690014221	H-loop/switch region; other site
103690014222	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690014223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690014224	S-adenosylmethionine binding site [chemical binding]; other site
103690014225	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
103690014226	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690014227	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
103690014228	Probable Catalytic site; other site
103690014229	metal-binding site
103690014230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014231	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690014232	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690014233	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
103690014234	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
103690014235	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
103690014236	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
103690014237	NADP binding site [chemical binding]; other site
103690014238	active site
103690014239	putative substrate binding site [chemical binding]; other site
103690014240	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
103690014241	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
103690014242	substrate binding site; other site
103690014243	metal-binding site
103690014244	Oligomer interface; other site
103690014245	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
103690014246	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690014247	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
103690014248	Probable Catalytic site; other site
103690014249	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690014250	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
103690014251	Probable Catalytic site; other site
103690014252	metal-binding site
103690014253	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690014254	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
103690014255	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
103690014256	Part of AAA domain; Region: AAA_19; pfam13245
103690014257	Family description; Region: UvrD_C_2; pfam13538
103690014258	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690014259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690014260	dimerization interface [polypeptide binding]; other site
103690014261	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690014262	dimer interface [polypeptide binding]; other site
103690014263	phosphorylation site [posttranslational modification]
103690014264	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014265	ATP binding site [chemical binding]; other site
103690014266	Mg2+ binding site [ion binding]; other site
103690014267	G-X-G motif; other site
103690014268	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
103690014269	S-layer homology domain; Region: SLH; pfam00395
103690014270	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690014271	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690014272	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
103690014273	ligand binding site [chemical binding]; other site
103690014274	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
103690014275	putative switch regulator; other site
103690014276	non-specific DNA interactions [nucleotide binding]; other site
103690014277	DNA binding site [nucleotide binding]
103690014278	sequence specific DNA binding site [nucleotide binding]; other site
103690014279	putative cAMP binding site [chemical binding]; other site
103690014280	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
103690014281	PhoU domain; Region: PhoU; pfam01895
103690014282	PhoU domain; Region: PhoU; pfam01895
103690014283	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690014284	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690014285	dimer interface [polypeptide binding]; other site
103690014286	phosphorylation site [posttranslational modification]
103690014287	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014288	ATP binding site [chemical binding]; other site
103690014289	Mg2+ binding site [ion binding]; other site
103690014290	G-X-G motif; other site
103690014291	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690014292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690014293	active site
103690014294	phosphorylation site [posttranslational modification]
103690014295	intermolecular recognition site; other site
103690014296	dimerization interface [polypeptide binding]; other site
103690014297	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690014298	DNA binding site [nucleotide binding]
103690014299	phosphodiesterase; Provisional; Region: PRK12704
103690014300	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
103690014301	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
103690014302	catalytic residues [active]
103690014303	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
103690014304	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
103690014305	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
103690014306	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
103690014307	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
103690014308	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
103690014309	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
103690014310	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
103690014311	cytochrome b subunit interaction site [polypeptide binding]; other site
103690014312	[2Fe-2S] cluster binding site [ion binding]; other site
103690014313	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690014314	NADH dehydrogenase-like protein; Provisional; Region: PTZ00318
103690014315	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
103690014316	diiron binding motif [ion binding]; other site
103690014317	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
103690014318	ABC1 family; Region: ABC1; cl17513
103690014319	Protein phosphatase 2C; Region: PP2C; pfam00481
103690014320	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
103690014321	active site
103690014322	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
103690014323	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690014324	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690014325	active site
103690014326	ATP binding site [chemical binding]; other site
103690014327	substrate binding site [chemical binding]; other site
103690014328	activation loop (A-loop); other site
103690014329	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
103690014330	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690014331	Domain of unknown function (DUF4360); Region: DUF4360; pfam14273
103690014332	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
103690014333	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
103690014334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
103690014335	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
103690014336	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690014337	CHAT domain; Region: CHAT; cl17868
103690014338	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
103690014339	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
103690014340	putative ligand binding site [chemical binding]; other site
103690014341	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
103690014342	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
103690014343	putative ligand binding site [chemical binding]; other site
103690014344	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
103690014345	AmpG-like permease; Region: 2A0125; TIGR00901
103690014346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690014347	Coenzyme A binding pocket [chemical binding]; other site
103690014348	HEAT repeats; Region: HEAT_2; pfam13646
103690014349	HEAT repeats; Region: HEAT_2; pfam13646
103690014350	HEAT repeats; Region: HEAT_2; pfam13646
103690014351	Cupin domain; Region: Cupin_2; cl17218
103690014352	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
103690014353	Predicted ester cyclase [General function prediction only]; Region: COG5485
103690014354	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690014355	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690014356	ligand binding site [chemical binding]; other site
103690014357	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
103690014358	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
103690014359	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
103690014360	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
103690014361	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
103690014362	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
103690014363	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
103690014364	Walker A/P-loop; other site
103690014365	ATP binding site [chemical binding]; other site
103690014366	Q-loop/lid; other site
103690014367	ABC transporter signature motif; other site
103690014368	Walker B; other site
103690014369	D-loop; other site
103690014370	H-loop/switch region; other site
103690014371	hypothetical protein; Provisional; Region: PRK13683
103690014372	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
103690014373	D1 interface; other site
103690014374	chlorophyll binding site; other site
103690014375	pheophytin binding site; other site
103690014376	beta carotene binding site; other site
103690014377	cytochrome b559 beta interface; other site
103690014378	quinone binding site; other site
103690014379	cytochrome b559 alpha interface; other site
103690014380	protein J interface; other site
103690014381	protein H interface; other site
103690014382	protein X interface; other site
103690014383	core light harvesting protein interface; other site
103690014384	protein L interface; other site
103690014385	CP43 interface; other site
103690014386	protein T interface; other site
103690014387	Fe binding site [ion binding]; other site
103690014388	protein M interface; other site
103690014389	Mn-stabilizing polypeptide interface; other site
103690014390	bromide binding site; other site
103690014391	cytochrome c-550 interface; other site
103690014392	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
103690014393	aromatic arch; other site
103690014394	DCoH dimer interaction site [polypeptide binding]; other site
103690014395	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
103690014396	DCoH tetramer interaction site [polypeptide binding]; other site
103690014397	substrate binding site [chemical binding]; other site
103690014398	S-layer homology domain; Region: SLH; pfam00395
103690014399	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690014400	Predicted transcriptional regulator [Transcription]; Region: COG1959
103690014401	Transcriptional regulator; Region: Rrf2; pfam02082
103690014402	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
103690014403	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
103690014404	dimer interface [polypeptide binding]; other site
103690014405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690014406	catalytic residue [active]
103690014407	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
103690014408	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690014409	HSP70 interaction site [polypeptide binding]; other site
103690014410	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
103690014411	active site
103690014412	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
103690014413	active site
103690014414	tellurite resistance protein terB; Region: terB; cd07176
103690014415	putative metal binding site [ion binding]; other site
103690014416	flavoprotein, HI0933 family; Region: TIGR00275
103690014417	Rubredoxin [Energy production and conversion]; Region: COG1773
103690014418	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
103690014419	iron binding site [ion binding]; other site
103690014420	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
103690014421	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
103690014422	[2Fe-2S] cluster binding site [ion binding]; other site
103690014423	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690014424	structural tetrad; other site
103690014425	PQQ-like domain; Region: PQQ_2; pfam13360
103690014426	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690014427	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
103690014428	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
103690014429	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
103690014430	intersubunit interface [polypeptide binding]; other site
103690014431	active site
103690014432	zinc binding site [ion binding]; other site
103690014433	Na+ binding site [ion binding]; other site
103690014434	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690014435	PAS domain; Region: PAS_9; pfam13426
103690014436	putative active site [active]
103690014437	heme pocket [chemical binding]; other site
103690014438	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690014439	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
103690014440	putative switch regulator; other site
103690014441	non-specific DNA interactions [nucleotide binding]; other site
103690014442	DNA binding site [nucleotide binding]
103690014443	sequence specific DNA binding site [nucleotide binding]; other site
103690014444	putative cAMP binding site [chemical binding]; other site
103690014445	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
103690014446	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
103690014447	dimer interface [polypeptide binding]; other site
103690014448	active site
103690014449	metal binding site [ion binding]; metal-binding site
103690014450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690014451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690014452	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
103690014453	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
103690014454	active site 1 [active]
103690014455	dimer interface [polypeptide binding]; other site
103690014456	hexamer interface [polypeptide binding]; other site
103690014457	active site 2 [active]
103690014458	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
103690014459	active site
103690014460	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690014461	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
103690014462	C-terminal domain interface [polypeptide binding]; other site
103690014463	GSH binding site (G-site) [chemical binding]; other site
103690014464	dimer interface [polypeptide binding]; other site
103690014465	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
103690014466	N-terminal domain interface [polypeptide binding]; other site
103690014467	dimer interface [polypeptide binding]; other site
103690014468	substrate binding pocket (H-site) [chemical binding]; other site
103690014469	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
103690014470	Glucose inhibited division protein A; Region: GIDA; pfam01134
103690014471	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
103690014472	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
103690014473	Walker A/P-loop; other site
103690014474	ATP binding site [chemical binding]; other site
103690014475	Q-loop/lid; other site
103690014476	ABC transporter signature motif; other site
103690014477	Walker B; other site
103690014478	D-loop; other site
103690014479	H-loop/switch region; other site
103690014480	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
103690014481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690014482	dimer interface [polypeptide binding]; other site
103690014483	conserved gate region; other site
103690014484	putative PBP binding loops; other site
103690014485	ABC-ATPase subunit interface; other site
103690014486	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
103690014487	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690014488	dimer interface [polypeptide binding]; other site
103690014489	conserved gate region; other site
103690014490	putative PBP binding loops; other site
103690014491	ABC-ATPase subunit interface; other site
103690014492	phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975
103690014493	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
103690014494	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
103690014495	lipoprotein signal peptidase; Provisional; Region: PRK14787
103690014496	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690014497	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690014498	phosphopeptide binding site; other site
103690014499	Transglycosylase; Region: Transgly; pfam00912
103690014500	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
103690014501	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690014502	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
103690014503	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
103690014504	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690014505	active site
103690014506	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
103690014507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690014508	dimer interface [polypeptide binding]; other site
103690014509	conserved gate region; other site
103690014510	ABC-ATPase subunit interface; other site
103690014511	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
103690014512	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
103690014513	HAMP domain; Region: HAMP; pfam00672
103690014514	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690014515	dimer interface [polypeptide binding]; other site
103690014516	phosphorylation site [posttranslational modification]
103690014517	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014518	ATP binding site [chemical binding]; other site
103690014519	Mg2+ binding site [ion binding]; other site
103690014520	G-X-G motif; other site
103690014521	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
103690014522	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
103690014523	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
103690014524	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
103690014525	tandem repeat interface [polypeptide binding]; other site
103690014526	oligomer interface [polypeptide binding]; other site
103690014527	active site residues [active]
103690014528	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
103690014529	tandem repeat interface [polypeptide binding]; other site
103690014530	oligomer interface [polypeptide binding]; other site
103690014531	active site residues [active]
103690014532	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
103690014533	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
103690014534	homotetramer interface [polypeptide binding]; other site
103690014535	FMN binding site [chemical binding]; other site
103690014536	homodimer contacts [polypeptide binding]; other site
103690014537	putative active site [active]
103690014538	putative substrate binding site [chemical binding]; other site
103690014539	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
103690014540	protein I interface; other site
103690014541	D2 interface; other site
103690014542	protein T interface; other site
103690014543	chlorophyll binding site; other site
103690014544	beta carotene binding site; other site
103690014545	pheophytin binding site; other site
103690014546	manganese-stabilizing polypeptide interface; other site
103690014547	CP43 interface; other site
103690014548	protein L interface; other site
103690014549	oxygen evolving complex binding site; other site
103690014550	bromide binding site; other site
103690014551	quinone binding site; other site
103690014552	Fe binding site [ion binding]; other site
103690014553	core light harvesting interface; other site
103690014554	cytochrome b559 alpha subunit interface; other site
103690014555	cytochrome c-550 interface; other site
103690014556	protein J interface; other site
103690014557	Tudor domain; Region: TUDOR; smart00333
103690014558	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
103690014559	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
103690014560	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
103690014561	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
103690014562	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
103690014563	Malic enzyme, N-terminal domain; Region: malic; pfam00390
103690014564	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
103690014565	putative NAD(P) binding site [chemical binding]; other site
103690014566	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
103690014567	HsdM N-terminal domain; Region: HsdM_N; pfam12161
103690014568	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690014569	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
103690014570	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690014571	putative active site [active]
103690014572	bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982
103690014573	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
103690014574	oligomeric interface; other site
103690014575	homodimer interface [polypeptide binding]; other site
103690014576	putative active site [active]
103690014577	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
103690014578	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
103690014579	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
103690014580	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
103690014581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
103690014582	ATP binding site [chemical binding]; other site
103690014583	putative Mg++ binding site [ion binding]; other site
103690014584	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
103690014585	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
103690014586	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690014587	metal binding site [ion binding]; metal-binding site
103690014588	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690014589	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690014590	glycine dehydrogenase; Provisional; Region: PRK05367
103690014591	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
103690014592	tetramer interface [polypeptide binding]; other site
103690014593	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690014594	catalytic residue [active]
103690014595	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
103690014596	tetramer interface [polypeptide binding]; other site
103690014597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690014598	catalytic residue [active]
103690014599	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
103690014600	lipoyl attachment site [posttranslational modification]; other site
103690014601	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
103690014602	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
103690014603	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690014604	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690014605	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690014606	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
103690014607	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
103690014608	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
103690014609	PYR/PP interface [polypeptide binding]; other site
103690014610	dimer interface [polypeptide binding]; other site
103690014611	TPP binding site [chemical binding]; other site
103690014612	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
103690014613	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
103690014614	TPP-binding site [chemical binding]; other site
103690014615	dimer interface [polypeptide binding]; other site
103690014616	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690014617	H+ Antiporter protein; Region: 2A0121; TIGR00900
103690014618	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
103690014619	putative substrate translocation pore; other site
103690014620	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
103690014621	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
103690014622	C-terminal domain interface [polypeptide binding]; other site
103690014623	active site
103690014624	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
103690014625	active site
103690014626	N-terminal domain interface [polypeptide binding]; other site
103690014627	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) [Signal transduction mechanisms]; Region: COG3476
103690014628	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
103690014629	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
103690014630	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
103690014631	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
103690014632	Predicted membrane protein [Function unknown]; Region: COG1808
103690014633	TLC ATP/ADP transporter; Region: TLC; cl03940
103690014634	HEAT repeats; Region: HEAT_2; pfam13646
103690014635	translation initiation factor 3; Provisional; Region: infC; CHL00199
103690014636	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
103690014637	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
103690014638	hydrolase, alpha/beta fold family protein; Region: PLN02824
103690014639	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
103690014640	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
103690014641	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
103690014642	putative valine binding site [chemical binding]; other site
103690014643	dimer interface [polypeptide binding]; other site
103690014644	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
103690014645	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690014646	Homeodomain-like domain; Region: HTH_23; pfam13384
103690014647	Winged helix-turn helix; Region: HTH_33; pfam13592
103690014648	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690014649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690014650	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690014651	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
103690014652	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
103690014653	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
103690014654	Ion transport protein; Region: Ion_trans; pfam00520
103690014655	Ion channel; Region: Ion_trans_2; pfam07885
103690014656	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
103690014657	Double zinc ribbon; Region: DZR; pfam12773
103690014658	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
103690014659	nucleoside/Zn binding site; other site
103690014660	dimer interface [polypeptide binding]; other site
103690014661	catalytic motif [active]
103690014662	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690014663	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690014664	active site
103690014665	phosphorylation site [posttranslational modification]
103690014666	intermolecular recognition site; other site
103690014667	dimerization interface [polypeptide binding]; other site
103690014668	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690014669	DNA binding residues [nucleotide binding]
103690014670	dimerization interface [polypeptide binding]; other site
103690014671	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
103690014672	Histidine kinase; Region: HisKA_3; pfam07730
103690014673	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014674	ATP binding site [chemical binding]; other site
103690014675	Mg2+ binding site [ion binding]; other site
103690014676	G-X-G motif; other site
103690014677	P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein [Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism]; Region: CpxP; COG3678
103690014678	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
103690014679	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
103690014680	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
103690014681	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
103690014682	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
103690014683	dimer interface [polypeptide binding]; other site
103690014684	decamer (pentamer of dimers) interface [polypeptide binding]; other site
103690014685	catalytic triad [active]
103690014686	peroxidatic and resolving cysteines [active]
103690014687	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
103690014688	putative catalytic residues [active]
103690014689	chaperone protein DnaJ; Provisional; Region: PRK14299
103690014690	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
103690014691	HSP70 interaction site [polypeptide binding]; other site
103690014692	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
103690014693	substrate binding site [polypeptide binding]; other site
103690014694	dimer interface [polypeptide binding]; other site
103690014695	Predicted kinase [General function prediction only]; Region: COG4639
103690014696	AAA domain; Region: AAA_17; pfam13207
103690014697	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
103690014698	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
103690014699	ligand binding site; other site
103690014700	oligomer interface; other site
103690014701	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
103690014702	dimer interface [polypeptide binding]; other site
103690014703	N-terminal domain interface [polypeptide binding]; other site
103690014704	sulfate 1 binding site; other site
103690014705	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
103690014706	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
103690014707	active site
103690014708	homodimer interface [polypeptide binding]; other site
103690014709	catalytic site [active]
103690014710	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
103690014711	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690014712	Fasciclin domain; Region: Fasciclin; pfam02469
103690014713	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
103690014714	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
103690014715	Protein of unknown function (DUF2393); Region: DUF2393; pfam09624
103690014716	TIGR02588 family protein; Region: TIGR02588
103690014717	putative integral membrane protein TIGR02587; Region: TIGR02587
103690014718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
103690014719	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
103690014720	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
103690014721	nucleotide binding site [chemical binding]; other site
103690014722	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
103690014723	D-xylulose kinase; Region: XylB; TIGR01312
103690014724	nucleotide binding site [chemical binding]; other site
103690014725	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
103690014726	TPR repeat; Region: TPR_11; pfam13414
103690014727	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690014728	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690014729	binding surface
103690014730	TPR motif; other site
103690014731	TPR repeat; Region: TPR_11; pfam13414
103690014732	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690014733	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
103690014734	putative C-terminal domain interface [polypeptide binding]; other site
103690014735	putative GSH binding site (G-site) [chemical binding]; other site
103690014736	putative dimer interface [polypeptide binding]; other site
103690014737	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
103690014738	N-terminal domain interface [polypeptide binding]; other site
103690014739	dimer interface [polypeptide binding]; other site
103690014740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
103690014741	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
103690014742	Predicted membrane protein [Function unknown]; Region: COG3686
103690014743	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
103690014744	DRTGG domain; Region: DRTGG; pfam07085
103690014745	AAA domain; Region: AAA_26; pfam13500
103690014746	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
103690014747	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690014748	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690014749	active site
103690014750	ATP binding site [chemical binding]; other site
103690014751	substrate binding site [chemical binding]; other site
103690014752	activation loop (A-loop); other site
103690014753	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
103690014754	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
103690014755	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690014756	active site
103690014757	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
103690014758	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
103690014759	Zn2+ binding site [ion binding]; other site
103690014760	Mg2+ binding site [ion binding]; other site
103690014761	quinolinate synthetase; Provisional; Region: PRK09375
103690014762	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
103690014763	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
103690014764	putative active site [active]
103690014765	putative metal binding site [ion binding]; other site
103690014766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690014767	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690014768	Probable transposase; Region: OrfB_IS605; pfam01385
103690014769	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690014770	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
103690014771	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
103690014772	trmE is a tRNA modification GTPase; Region: trmE; cd04164
103690014773	G1 box; other site
103690014774	GTP/Mg2+ binding site [chemical binding]; other site
103690014775	Switch I region; other site
103690014776	G2 box; other site
103690014777	Switch II region; other site
103690014778	G3 box; other site
103690014779	G4 box; other site
103690014780	G5 box; other site
103690014781	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
103690014782	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690014783	putative active site [active]
103690014784	Predicted methyltransferases [General function prediction only]; Region: COG0313
103690014785	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
103690014786	putative SAM binding site [chemical binding]; other site
103690014787	putative homodimer interface [polypeptide binding]; other site
103690014788	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
103690014789	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
103690014790	substrate binding site [chemical binding]; other site
103690014791	ATP binding site [chemical binding]; other site
103690014792	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
103690014793	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
103690014794	active site
103690014795	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
103690014796	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
103690014797	Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687
103690014798	substrate binding pocket [chemical binding]; other site
103690014799	substrate-Mg2+ binding site; other site
103690014800	aspartate-rich region 1; other site
103690014801	active site lid residues [active]
103690014802	aspartate-rich region 2; other site
103690014803	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690014804	Cytochrome P450; Region: p450; pfam00067
103690014805	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690014806	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690014807	active site
103690014808	ATP binding site [chemical binding]; other site
103690014809	substrate binding site [chemical binding]; other site
103690014810	activation loop (A-loop); other site
103690014811	AAA ATPase domain; Region: AAA_16; pfam13191
103690014812	Predicted ATPase [General function prediction only]; Region: COG3899
103690014813	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690014814	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690014815	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690014816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690014817	dimer interface [polypeptide binding]; other site
103690014818	phosphorylation site [posttranslational modification]
103690014819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014820	ATP binding site [chemical binding]; other site
103690014821	Mg2+ binding site [ion binding]; other site
103690014822	G-X-G motif; other site
103690014823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690014824	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
103690014825	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
103690014826	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
103690014827	MarR family; Region: MarR; pfam01047
103690014828	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
103690014829	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
103690014830	putative active site [active]
103690014831	putative metal binding residues [ion binding]; other site
103690014832	signature motif; other site
103690014833	putative dimer interface [polypeptide binding]; other site
103690014834	putative phosphate binding site [ion binding]; other site
103690014835	hypothetical protein; Provisional; Region: PRK09256
103690014836	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
103690014837	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
103690014838	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
103690014839	active site
103690014840	SAM binding site [chemical binding]; other site
103690014841	homodimer interface [polypeptide binding]; other site
103690014842	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
103690014843	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
103690014844	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
103690014845	active site
103690014846	(T/H)XGH motif; other site
103690014847	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
103690014848	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
103690014849	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
103690014850	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
103690014851	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
103690014852	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690014853	ATP binding site [chemical binding]; other site
103690014854	putative Mg++ binding site [ion binding]; other site
103690014855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690014856	nucleotide binding region [chemical binding]; other site
103690014857	ATP-binding site [chemical binding]; other site
103690014858	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
103690014859	DNA polymerase III subunit delta'; Validated; Region: PRK07399
103690014860	AAA ATPase domain; Region: AAA_16; pfam13191
103690014861	DNA polymerase III subunit delta'; Validated; Region: PRK08485
103690014862	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
103690014863	Phage Tail Collar Domain; Region: Collar; pfam07484
103690014864	thymidylate kinase; Validated; Region: tmk; PRK00698
103690014865	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
103690014866	TMP-binding site; other site
103690014867	ATP-binding site [chemical binding]; other site
103690014868	M28 Zn-Peptidases; Region: M28_like_1; cd05640
103690014869	Peptidase family M28; Region: Peptidase_M28; pfam04389
103690014870	metal binding site [ion binding]; metal-binding site
103690014871	Uncharacterized conserved protein [Function unknown]; Region: COG2836
103690014872	Predicted membrane protein [Function unknown]; Region: COG2717
103690014873	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
103690014874	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
103690014875	NAD binding site [chemical binding]; other site
103690014876	homodimer interface [polypeptide binding]; other site
103690014877	active site
103690014878	substrate binding site [chemical binding]; other site
103690014879	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690014880	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690014881	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690014882	Walker A/P-loop; other site
103690014883	ATP binding site [chemical binding]; other site
103690014884	Q-loop/lid; other site
103690014885	ABC transporter signature motif; other site
103690014886	Walker B; other site
103690014887	D-loop; other site
103690014888	H-loop/switch region; other site
103690014889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690014890	dimer interface [polypeptide binding]; other site
103690014891	phosphorylation site [posttranslational modification]
103690014892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014893	ATP binding site [chemical binding]; other site
103690014894	Mg2+ binding site [ion binding]; other site
103690014895	G-X-G motif; other site
103690014896	Hydrogenase/urease accessory protein [Posttranslational modification, protein turnover, chaperones]; Region: HupE; COG2370
103690014897	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
103690014898	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
103690014899	ATP binding site [chemical binding]; other site
103690014900	Mg++ binding site [ion binding]; other site
103690014901	motif III; other site
103690014902	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690014903	nucleotide binding region [chemical binding]; other site
103690014904	ATP-binding site [chemical binding]; other site
103690014905	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
103690014906	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
103690014907	homodecamer interface [polypeptide binding]; other site
103690014908	GTP cyclohydrolase I; Provisional; Region: PLN03044
103690014909	active site
103690014910	putative catalytic site residues [active]
103690014911	zinc binding site [ion binding]; other site
103690014912	GTP-CH-I/GFRP interaction surface; other site
103690014913	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
103690014914	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
103690014915	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
103690014916	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
103690014917	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
103690014918	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
103690014919	active site
103690014920	dimer interface [polypeptide binding]; other site
103690014921	motif 1; other site
103690014922	motif 2; other site
103690014923	motif 3; other site
103690014924	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
103690014925	anticodon binding site; other site
103690014926	L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434
103690014927	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
103690014928	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
103690014929	dimer interface [polypeptide binding]; other site
103690014930	active site
103690014931	aspartate-rich active site metal binding site; other site
103690014932	allosteric magnesium binding site [ion binding]; other site
103690014933	Schiff base residues; other site
103690014934	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690014935	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690014936	dimerization interface [polypeptide binding]; other site
103690014937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690014938	dimer interface [polypeptide binding]; other site
103690014939	phosphorylation site [posttranslational modification]
103690014940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690014941	ATP binding site [chemical binding]; other site
103690014942	Mg2+ binding site [ion binding]; other site
103690014943	G-X-G motif; other site
103690014944	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690014945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690014946	active site
103690014947	phosphorylation site [posttranslational modification]
103690014948	intermolecular recognition site; other site
103690014949	dimerization interface [polypeptide binding]; other site
103690014950	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690014951	DNA binding site [nucleotide binding]
103690014952	Uncharacterized conserved protein [Function unknown]; Region: COG1432
103690014953	LabA_like proteins; Region: LabA; cd10911
103690014954	putative metal binding site [ion binding]; other site
103690014955	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
103690014956	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
103690014957	Walker A/P-loop; other site
103690014958	ATP binding site [chemical binding]; other site
103690014959	Q-loop/lid; other site
103690014960	ABC transporter signature motif; other site
103690014961	Walker B; other site
103690014962	D-loop; other site
103690014963	H-loop/switch region; other site
103690014964	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690014965	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690014966	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690014967	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690014968	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690014969	Walker A/P-loop; other site
103690014970	ATP binding site [chemical binding]; other site
103690014971	Q-loop/lid; other site
103690014972	ABC transporter signature motif; other site
103690014973	Walker B; other site
103690014974	D-loop; other site
103690014975	H-loop/switch region; other site
103690014976	magnesium chelatase, H subunit; Region: BchH; TIGR02025
103690014977	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
103690014978	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
103690014979	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
103690014980	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
103690014981	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
103690014982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
103690014983	DNA-binding site [nucleotide binding]; DNA binding site
103690014984	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690014985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690014986	homodimer interface [polypeptide binding]; other site
103690014987	catalytic residue [active]
103690014988	FecR protein; Region: FecR; pfam04773
103690014989	S-layer homology domain; Region: SLH; pfam00395
103690014990	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690014991	Uncharacterized conserved protein [Function unknown]; Region: COG4715
103690014992	SWIM zinc finger; Region: SWIM; pfam04434
103690014993	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
103690014994	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690014995	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
103690014996	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
103690014997	active site
103690014998	ribulose/triose binding site [chemical binding]; other site
103690014999	phosphate binding site [ion binding]; other site
103690015000	substrate (anthranilate) binding pocket [chemical binding]; other site
103690015001	product (indole) binding pocket [chemical binding]; other site
103690015002	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
103690015003	Uncharacterized conserved protein [Function unknown]; Region: COG1430
103690015004	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690015005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015006	active site
103690015007	phosphorylation site [posttranslational modification]
103690015008	intermolecular recognition site; other site
103690015009	dimerization interface [polypeptide binding]; other site
103690015010	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690015011	DNA binding site [nucleotide binding]
103690015012	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
103690015013	ATP-NAD kinase; Region: NAD_kinase; pfam01513
103690015014	Ycf39; Provisional; Region: ycf39; CHL00194
103690015015	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
103690015016	NAD(P) binding site [chemical binding]; other site
103690015017	putative active site [active]
103690015018	cytochrome b6-f complex subunit PetM; Reviewed; Region: petM; PRK11876
103690015019	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
103690015020	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
103690015021	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
103690015022	Transposase; Region: DEDD_Tnp_IS110; pfam01548
103690015023	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
103690015024	EamA-like transporter family; Region: EamA; pfam00892
103690015025	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
103690015026	EamA-like transporter family; Region: EamA; pfam00892
103690015027	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690015028	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690015029	structural tetrad; other site
103690015030	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690015031	G2 box; other site
103690015032	Switch I region; other site
103690015033	G3 box; other site
103690015034	Switch II region; other site
103690015035	G4 box; other site
103690015036	Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453
103690015037	active site
103690015038	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690015039	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690015040	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690015041	P-loop; other site
103690015042	Magnesium ion binding site [ion binding]; other site
103690015043	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690015044	Cytochrome P450; Region: p450; pfam00067
103690015045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
103690015046	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
103690015047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
103690015048	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
103690015049	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
103690015050	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
103690015051	active site
103690015052	intersubunit interface [polypeptide binding]; other site
103690015053	catalytic residue [active]
103690015054	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
103690015055	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
103690015056	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
103690015057	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
103690015058	trimer interface [polypeptide binding]; other site
103690015059	active site
103690015060	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
103690015061	catalytic site [active]
103690015062	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
103690015063	glutaminase; Provisional; Region: PRK00971
103690015064	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
103690015065	cell division protein; Validated; Region: ftsH; CHL00176
103690015066	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690015067	Walker A motif; other site
103690015068	ATP binding site [chemical binding]; other site
103690015069	Walker B motif; other site
103690015070	arginine finger; other site
103690015071	Peptidase family M41; Region: Peptidase_M41; pfam01434
103690015072	Predicted flavoprotein [General function prediction only]; Region: COG0431
103690015073	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
103690015074	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
103690015075	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
103690015076	Walker A/P-loop; other site
103690015077	ATP binding site [chemical binding]; other site
103690015078	Q-loop/lid; other site
103690015079	ABC transporter signature motif; other site
103690015080	Walker B; other site
103690015081	D-loop; other site
103690015082	H-loop/switch region; other site
103690015083	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
103690015084	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
103690015085	Walker A/P-loop; other site
103690015086	ATP binding site [chemical binding]; other site
103690015087	Q-loop/lid; other site
103690015088	ABC transporter signature motif; other site
103690015089	Walker B; other site
103690015090	D-loop; other site
103690015091	H-loop/switch region; other site
103690015092	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
103690015093	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
103690015094	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
103690015095	dimer interface [polypeptide binding]; other site
103690015096	ssDNA binding site [nucleotide binding]; other site
103690015097	tetramer (dimer of dimers) interface [polypeptide binding]; other site
103690015098	hypothetical protein; Provisional; Region: PRK06185
103690015099	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690015100	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
103690015101	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
103690015102	Walker A/P-loop; other site
103690015103	ATP binding site [chemical binding]; other site
103690015104	Q-loop/lid; other site
103690015105	ABC transporter signature motif; other site
103690015106	Walker B; other site
103690015107	D-loop; other site
103690015108	H-loop/switch region; other site
103690015109	TOBE domain; Region: TOBE_2; pfam08402
103690015110	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690015111	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
103690015112	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
103690015113	IMP binding site; other site
103690015114	GDP-binding site [chemical binding]; other site
103690015115	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
103690015116	5S rRNA interface [nucleotide binding]; other site
103690015117	CTC domain interface [polypeptide binding]; other site
103690015118	L16 interface [polypeptide binding]; other site
103690015119	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
103690015120	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
103690015121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
103690015122	Predicted kinase [General function prediction only]; Region: COG0645
103690015123	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
103690015124	ATP-binding site [chemical binding]; other site
103690015125	Gluconate-6-phosphate binding site [chemical binding]; other site
103690015126	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
103690015127	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
103690015128	generic binding surface II; other site
103690015129	ssDNA binding site; other site
103690015130	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690015131	ATP binding site [chemical binding]; other site
103690015132	putative Mg++ binding site [ion binding]; other site
103690015133	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690015134	nucleotide binding region [chemical binding]; other site
103690015135	ATP-binding site [chemical binding]; other site
103690015136	elongation factor Ts; Provisional; Region: tsf; PRK09377
103690015137	UBA/TS-N domain; Region: UBA; pfam00627
103690015138	Elongation factor TS; Region: EF_TS; pfam00889
103690015139	Elongation factor TS; Region: EF_TS; pfam00889
103690015140	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
103690015141	rRNA interaction site [nucleotide binding]; other site
103690015142	S8 interaction site; other site
103690015143	putative laminin-1 binding site; other site
103690015144	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
103690015145	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
103690015146	Probable Catalytic site; other site
103690015147	metal-binding site
103690015148	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
103690015149	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
103690015150	AAA domain; Region: AAA_17; pfam13207
103690015151	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
103690015152	argininosuccinate synthase; Provisional; Region: PRK13820
103690015153	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
103690015154	ANP binding site [chemical binding]; other site
103690015155	Substrate Binding Site II [chemical binding]; other site
103690015156	Substrate Binding Site I [chemical binding]; other site
103690015157	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
103690015158	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
103690015159	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
103690015160	anti sigma factor interaction site; other site
103690015161	regulatory phosphorylation site [posttranslational modification]; other site
103690015162	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
103690015163	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
103690015164	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
103690015165	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
103690015166	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
103690015167	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
103690015168	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
103690015169	dimer interface [polypeptide binding]; other site
103690015170	active site
103690015171	glycine-pyridoxal phosphate binding site [chemical binding]; other site
103690015172	folate binding site [chemical binding]; other site
103690015173	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
103690015174	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
103690015175	Mg++ binding site [ion binding]; other site
103690015176	putative catalytic motif [active]
103690015177	substrate binding site [chemical binding]; other site
103690015178	competence damage-inducible protein A; Provisional; Region: PRK00549
103690015179	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
103690015180	putative MPT binding site; other site
103690015181	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
103690015182	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
103690015183	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
103690015184	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
103690015185	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
103690015186	substrate binding site [chemical binding]; other site
103690015187	active site
103690015188	catalytic residues [active]
103690015189	heterodimer interface [polypeptide binding]; other site
103690015190	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690015191	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690015192	active site
103690015193	ATP binding site [chemical binding]; other site
103690015194	substrate binding site [chemical binding]; other site
103690015195	activation loop (A-loop); other site
103690015196	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690015197	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690015198	cofactor binding site; other site
103690015199	DNA binding site [nucleotide binding]
103690015200	substrate interaction site [chemical binding]; other site
103690015201	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690015202	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690015203	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690015204	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690015205	Bpu10I restriction endonuclease; Region: RE_Bpu10I; pfam09549
103690015206	Predicted GTPase [General function prediction only]; Region: COG3596
103690015207	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
103690015208	G1 box; other site
103690015209	GTP/Mg2+ binding site [chemical binding]; other site
103690015210	G2 box; other site
103690015211	Switch I region; other site
103690015212	G3 box; other site
103690015213	Switch II region; other site
103690015214	G4 box; other site
103690015215	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
103690015216	AMIN domain; Region: AMIN; pfam11741
103690015217	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
103690015218	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
103690015219	Bacterial sugar transferase; Region: Bac_transf; pfam02397
103690015220	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
103690015221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690015222	dimer interface [polypeptide binding]; other site
103690015223	conserved gate region; other site
103690015224	putative PBP binding loops; other site
103690015225	ABC-ATPase subunit interface; other site
103690015226	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
103690015227	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
103690015228	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
103690015229	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
103690015230	NADP binding site [chemical binding]; other site
103690015231	active site
103690015232	putative substrate binding site [chemical binding]; other site
103690015233	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
103690015234	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
103690015235	NADP-binding site; other site
103690015236	homotetramer interface [polypeptide binding]; other site
103690015237	substrate binding site [chemical binding]; other site
103690015238	homodimer interface [polypeptide binding]; other site
103690015239	active site
103690015240	Bacterial sugar transferase; Region: Bac_transf; pfam02397
103690015241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690015242	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
103690015243	putative ADP-binding pocket [chemical binding]; other site
103690015244	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690015245	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
103690015246	putative NAD(P) binding site [chemical binding]; other site
103690015247	active site
103690015248	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
103690015249	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
103690015250	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
103690015251	Cytochrome P450; Region: p450; cl12078
103690015252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015253	TPR motif; other site
103690015254	binding surface
103690015255	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015256	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
103690015257	AAA ATPase domain; Region: AAA_16; pfam13191
103690015258	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690015259	structural tetrad; other site
103690015260	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690015261	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690015262	structural tetrad; other site
103690015263	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690015264	structural tetrad; other site
103690015265	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690015266	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
103690015267	MEKHLA domain; Region: MEKHLA; pfam08670
103690015268	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
103690015269	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690015270	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
103690015271	Protein kinase domain; Region: Pkinase; pfam00069
103690015272	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690015273	active site
103690015274	ATP binding site [chemical binding]; other site
103690015275	substrate binding site [chemical binding]; other site
103690015276	activation loop (A-loop); other site
103690015277	Uncharacterized conserved protein [Function unknown]; Region: COG1432
103690015278	LabA_like proteins; Region: LabA; cd10911
103690015279	putative metal binding site [ion binding]; other site
103690015280	2-isopropylmalate synthase; Validated; Region: PRK00915
103690015281	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
103690015282	active site
103690015283	catalytic residues [active]
103690015284	metal binding site [ion binding]; metal-binding site
103690015285	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
103690015286	diaminopimelate epimerase; Provisional; Region: PRK13577
103690015287	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
103690015288	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
103690015289	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
103690015290	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690015291	ATP binding site [chemical binding]; other site
103690015292	putative Mg++ binding site [ion binding]; other site
103690015293	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690015294	nucleotide binding region [chemical binding]; other site
103690015295	ATP-binding site [chemical binding]; other site
103690015296	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015297	putative active site [active]
103690015298	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
103690015299	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
103690015300	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
103690015301	dimer interface [polypeptide binding]; other site
103690015302	motif 1; other site
103690015303	active site
103690015304	motif 2; other site
103690015305	motif 3; other site
103690015306	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
103690015307	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
103690015308	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
103690015309	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
103690015310	active site
103690015311	Riboflavin kinase; Region: Flavokinase; pfam01687
103690015312	MoxR-like ATPases [General function prediction only]; Region: COG0714
103690015313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690015314	Walker A motif; other site
103690015315	ATP binding site [chemical binding]; other site
103690015316	Walker B motif; other site
103690015317	arginine finger; other site
103690015318	Dihaem cytochrome c; Region: DHC; pfam09626
103690015319	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
103690015320	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
103690015321	ATP binding site [chemical binding]; other site
103690015322	putative Mg++ binding site [ion binding]; other site
103690015323	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
103690015324	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015325	putative active site [active]
103690015326	aspartate aminotransferase; Provisional; Region: PRK05764
103690015327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690015328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690015329	homodimer interface [polypeptide binding]; other site
103690015330	catalytic residue [active]
103690015331	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015332	putative active site [active]
103690015333	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
103690015334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680
103690015335	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690015336	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
103690015337	putative metal binding site; other site
103690015338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015339	TPR motif; other site
103690015340	binding surface
103690015341	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015342	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015343	binding surface
103690015344	TPR repeat; Region: TPR_11; pfam13414
103690015345	TPR motif; other site
103690015346	TPR repeat; Region: TPR_11; pfam13414
103690015347	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
103690015348	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
103690015349	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
103690015350	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
103690015351	protein I interface; other site
103690015352	D2 interface; other site
103690015353	protein T interface; other site
103690015354	chlorophyll binding site; other site
103690015355	beta carotene binding site; other site
103690015356	pheophytin binding site; other site
103690015357	manganese-stabilizing polypeptide interface; other site
103690015358	CP43 interface; other site
103690015359	protein L interface; other site
103690015360	oxygen evolving complex binding site; other site
103690015361	bromide binding site; other site
103690015362	quinone binding site; other site
103690015363	Fe binding site [ion binding]; other site
103690015364	core light harvesting interface; other site
103690015365	cytochrome b559 alpha subunit interface; other site
103690015366	cytochrome c-550 interface; other site
103690015367	protein J interface; other site
103690015368	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690015369	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690015370	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
103690015371	Homeodomain-like domain; Region: HTH_23; pfam13384
103690015372	Winged helix-turn helix; Region: HTH_33; pfam13592
103690015373	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
103690015374	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
103690015375	active site
103690015376	catalytic triad [active]
103690015377	Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935
103690015378	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
103690015379	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
103690015380	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
103690015381	putative acyl-acceptor binding pocket; other site
103690015382	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
103690015383	nucleoside/Zn binding site; other site
103690015384	dimer interface [polypeptide binding]; other site
103690015385	catalytic motif [active]
103690015386	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
103690015387	GSH binding site [chemical binding]; other site
103690015388	catalytic residues [active]
103690015389	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
103690015390	NADH(P)-binding; Region: NAD_binding_10; pfam13460
103690015391	NAD(P) binding site [chemical binding]; other site
103690015392	putative active site [active]
103690015393	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
103690015394	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690015395	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690015396	structural tetrad; other site
103690015397	Cache domain; Region: Cache_1; pfam02743
103690015398	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690015399	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690015400	dimerization interface [polypeptide binding]; other site
103690015401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690015402	dimer interface [polypeptide binding]; other site
103690015403	phosphorylation site [posttranslational modification]
103690015404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015405	ATP binding site [chemical binding]; other site
103690015406	Mg2+ binding site [ion binding]; other site
103690015407	G-X-G motif; other site
103690015408	Response regulator receiver domain; Region: Response_reg; pfam00072
103690015409	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015410	active site
103690015411	phosphorylation site [posttranslational modification]
103690015412	intermolecular recognition site; other site
103690015413	dimerization interface [polypeptide binding]; other site
103690015414	Response regulator receiver domain; Region: Response_reg; pfam00072
103690015415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015416	active site
103690015417	phosphorylation site [posttranslational modification]
103690015418	intermolecular recognition site; other site
103690015419	dimerization interface [polypeptide binding]; other site
103690015420	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690015421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690015422	dimer interface [polypeptide binding]; other site
103690015423	phosphorylation site [posttranslational modification]
103690015424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015425	ATP binding site [chemical binding]; other site
103690015426	Mg2+ binding site [ion binding]; other site
103690015427	G-X-G motif; other site
103690015428	Response regulator receiver domain; Region: Response_reg; pfam00072
103690015429	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015430	active site
103690015431	phosphorylation site [posttranslational modification]
103690015432	intermolecular recognition site; other site
103690015433	dimerization interface [polypeptide binding]; other site
103690015434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015435	ATP binding site [chemical binding]; other site
103690015436	Mg2+ binding site [ion binding]; other site
103690015437	G-X-G motif; other site
103690015438	Uncharacterized conserved protein [Function unknown]; Region: COG3287
103690015439	FIST N domain; Region: FIST; pfam08495
103690015440	FIST C domain; Region: FIST_C; pfam10442
103690015441	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690015442	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690015443	dimer interface [polypeptide binding]; other site
103690015444	phosphorylation site [posttranslational modification]
103690015445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015446	ATP binding site [chemical binding]; other site
103690015447	Mg2+ binding site [ion binding]; other site
103690015448	G-X-G motif; other site
103690015449	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
103690015450	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690015451	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
103690015452	NADPH bind site [chemical binding]; other site
103690015453	putative FMN binding site [chemical binding]; other site
103690015454	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
103690015455	putative FMN binding site [chemical binding]; other site
103690015456	NADPH bind site [chemical binding]; other site
103690015457	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
103690015458	Protein of unknown function (DUF3592); Region: DUF3592; pfam12158
103690015459	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
103690015460	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
103690015461	homodimer interface [polypeptide binding]; other site
103690015462	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690015463	catalytic residue [active]
103690015464	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
103690015465	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
103690015466	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690015467	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
103690015468	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
103690015469	Cl- selectivity filter; other site
103690015470	Cl- binding residues [ion binding]; other site
103690015471	pore gating glutamate residue; other site
103690015472	dimer interface [polypeptide binding]; other site
103690015473	H+/Cl- coupling transport residue; other site
103690015474	FOG: CBS domain [General function prediction only]; Region: COG0517
103690015475	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690015476	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
103690015477	Ligand Binding Site [chemical binding]; other site
103690015478	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
103690015479	Ligand Binding Site [chemical binding]; other site
103690015480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
103690015481	conserved hypothetical protein; Region: TIGR03492
103690015482	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
103690015483	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
103690015484	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
103690015485	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690015486	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690015487	Fasciclin domain; Region: Fasciclin; pfam02469
103690015488	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
103690015489	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
103690015490	PAS fold; Region: PAS_4; pfam08448
103690015491	GAF domain; Region: GAF_3; pfam13492
103690015492	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690015493	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690015494	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690015495	metal binding site [ion binding]; metal-binding site
103690015496	active site
103690015497	I-site; other site
103690015498	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG5278
103690015499	PAS fold; Region: PAS_4; pfam08448
103690015500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690015501	putative active site [active]
103690015502	heme pocket [chemical binding]; other site
103690015503	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690015504	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690015505	metal binding site [ion binding]; metal-binding site
103690015506	active site
103690015507	I-site; other site
103690015508	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
103690015509	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
103690015510	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
103690015511	FMN binding site [chemical binding]; other site
103690015512	active site
103690015513	catalytic residues [active]
103690015514	substrate binding site [chemical binding]; other site
103690015515	AMIN domain; Region: AMIN; pfam11741
103690015516	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
103690015517	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690015518	ATP binding site [chemical binding]; other site
103690015519	putative Mg++ binding site [ion binding]; other site
103690015520	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690015521	nucleotide binding region [chemical binding]; other site
103690015522	ATP-binding site [chemical binding]; other site
103690015523	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
103690015524	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690015525	C-terminal domain interface [polypeptide binding]; other site
103690015526	GSH binding site (G-site) [chemical binding]; other site
103690015527	dimer interface [polypeptide binding]; other site
103690015528	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
103690015529	N-terminal domain interface [polypeptide binding]; other site
103690015530	dimer interface [polypeptide binding]; other site
103690015531	substrate binding pocket (H-site) [chemical binding]; other site
103690015532	conjugal transfer protein TraL; Provisional; Region: PRK13886
103690015533	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690015534	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690015535	dimer interface [polypeptide binding]; other site
103690015536	phosphorylation site [posttranslational modification]
103690015537	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015538	ATP binding site [chemical binding]; other site
103690015539	Mg2+ binding site [ion binding]; other site
103690015540	G-X-G motif; other site
103690015541	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690015542	catalytic core [active]
103690015543	ornithine carbamoyltransferase; Provisional; Region: PRK00779
103690015544	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
103690015545	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
103690015546	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
103690015547	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
103690015548	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
103690015549	Catalytic site [active]
103690015550	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
103690015551	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690015552	ATP binding site [chemical binding]; other site
103690015553	putative Mg++ binding site [ion binding]; other site
103690015554	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690015555	nucleotide binding region [chemical binding]; other site
103690015556	ATP-binding site [chemical binding]; other site
103690015557	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
103690015558	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690015559	Walker A/P-loop; other site
103690015560	ATP binding site [chemical binding]; other site
103690015561	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015562	putative active site [active]
103690015563	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015564	putative active site [active]
103690015565	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
103690015566	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
103690015567	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690015568	active site
103690015569	DGQHR domain; Region: DGQHR; TIGR03187
103690015570	DNA-sulfur modification-associated; Region: DndB; cl17621
103690015571	hypothetical protein; Provisional; Region: PRK06850
103690015572	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
103690015573	Active Sites [active]
103690015574	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690015575	non-specific DNA binding site [nucleotide binding]; other site
103690015576	salt bridge; other site
103690015577	sequence-specific DNA binding site [nucleotide binding]; other site
103690015578	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
103690015579	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690015580	Walker A/P-loop; other site
103690015581	ATP binding site [chemical binding]; other site
103690015582	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690015583	ABC transporter signature motif; other site
103690015584	Walker B; other site
103690015585	D-loop; other site
103690015586	Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337
103690015587	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
103690015588	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
103690015589	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
103690015590	siderophore binding site; other site
103690015591	AMIN domain; Region: AMIN; pfam11741
103690015592	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
103690015593	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
103690015594	N-terminal plug; other site
103690015595	ligand-binding site [chemical binding]; other site
103690015596	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
103690015597	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
103690015598	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015599	binding surface
103690015600	TPR motif; other site
103690015601	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
103690015602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015603	binding surface
103690015604	TPR motif; other site
103690015605	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690015606	binding surface
103690015607	TPR motif; other site
103690015608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690015609	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690015610	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015611	active site
103690015612	phosphorylation site [posttranslational modification]
103690015613	intermolecular recognition site; other site
103690015614	dimerization interface [polypeptide binding]; other site
103690015615	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690015616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015617	active site
103690015618	phosphorylation site [posttranslational modification]
103690015619	intermolecular recognition site; other site
103690015620	dimerization interface [polypeptide binding]; other site
103690015621	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690015622	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
103690015623	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
103690015624	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690015625	Walker A motif; other site
103690015626	ATP binding site [chemical binding]; other site
103690015627	Walker B motif; other site
103690015628	arginine finger; other site
103690015629	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
103690015630	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
103690015631	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
103690015632	DXD motif; other site
103690015633	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
103690015634	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
103690015635	metal binding site [ion binding]; metal-binding site
103690015636	dimer interface [polypeptide binding]; other site
103690015637	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
103690015638	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
103690015639	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690015640	Walker A motif; other site
103690015641	ATP binding site [chemical binding]; other site
103690015642	Walker B motif; other site
103690015643	arginine finger; other site
103690015644	Peptidase family M41; Region: Peptidase_M41; pfam01434
103690015645	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690015646	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690015647	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
103690015648	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
103690015649	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
103690015650	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690015651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690015652	motif II; other site
103690015653	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690015654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690015655	S-adenosylmethionine binding site [chemical binding]; other site
103690015656	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690015657	active site
103690015658	metal binding site [ion binding]; metal-binding site
103690015659	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690015660	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690015661	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690015662	active site
103690015663	ATP binding site [chemical binding]; other site
103690015664	substrate binding site [chemical binding]; other site
103690015665	activation loop (A-loop); other site
103690015666	GUN4-like; Region: GUN4; pfam05419
103690015667	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
103690015668	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1569
103690015669	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690015670	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
103690015671	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
103690015672	phosphopeptide binding site; other site
103690015673	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690015674	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690015675	active site
103690015676	ATP binding site [chemical binding]; other site
103690015677	substrate binding site [chemical binding]; other site
103690015678	activation loop (A-loop); other site
103690015679	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690015680	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690015681	Walker A/P-loop; other site
103690015682	ATP binding site [chemical binding]; other site
103690015683	Q-loop/lid; other site
103690015684	ABC transporter signature motif; other site
103690015685	Walker B; other site
103690015686	D-loop; other site
103690015687	H-loop/switch region; other site
103690015688	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
103690015689	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
103690015690	FeS/SAM binding site; other site
103690015691	HemN C-terminal domain; Region: HemN_C; pfam06969
103690015692	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
103690015693	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
103690015694	putative active site [active]
103690015695	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
103690015696	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
103690015697	putative tRNA-binding site [nucleotide binding]; other site
103690015698	B3/4 domain; Region: B3_4; pfam03483
103690015699	tRNA synthetase B5 domain; Region: B5; smart00874
103690015700	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
103690015701	dimer interface [polypeptide binding]; other site
103690015702	motif 1; other site
103690015703	motif 3; other site
103690015704	motif 2; other site
103690015705	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
103690015706	YciI-like protein; Reviewed; Region: PRK12864
103690015707	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
103690015708	ABC1 family; Region: ABC1; pfam03109
103690015709	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
103690015710	active site
103690015711	ATP binding site [chemical binding]; other site
103690015712	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
103690015713	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
103690015714	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
103690015715	Walker A/P-loop; other site
103690015716	ATP binding site [chemical binding]; other site
103690015717	Q-loop/lid; other site
103690015718	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
103690015719	ABC transporter signature motif; other site
103690015720	Walker B; other site
103690015721	D-loop; other site
103690015722	H-loop/switch region; other site
103690015723	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690015724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015725	active site
103690015726	phosphorylation site [posttranslational modification]
103690015727	intermolecular recognition site; other site
103690015728	dimerization interface [polypeptide binding]; other site
103690015729	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690015730	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690015731	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690015732	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690015733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690015734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690015735	dimer interface [polypeptide binding]; other site
103690015736	phosphorylation site [posttranslational modification]
103690015737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690015738	ATP binding site [chemical binding]; other site
103690015739	Mg2+ binding site [ion binding]; other site
103690015740	G-X-G motif; other site
103690015741	Response regulator receiver domain; Region: Response_reg; pfam00072
103690015742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690015743	active site
103690015744	phosphorylation site [posttranslational modification]
103690015745	intermolecular recognition site; other site
103690015746	dimerization interface [polypeptide binding]; other site
103690015747	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
103690015748	cyclase homology domain; Region: CHD; cd07302
103690015749	nucleotidyl binding site; other site
103690015750	metal binding site [ion binding]; metal-binding site
103690015751	dimer interface [polypeptide binding]; other site
103690015752	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690015753	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690015754	Coenzyme A binding pocket [chemical binding]; other site
103690015755	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
103690015756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690015757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690015758	homodimer interface [polypeptide binding]; other site
103690015759	catalytic residue [active]
103690015760	Uncharacterized protein family (UPF0227); Region: UPF0227; pfam05728
103690015761	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
103690015762	glutathione-disulfide reductase, plant; Region: gluta_reduc_2; TIGR01424
103690015763	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690015764	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
103690015765	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
103690015766	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
103690015767	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
103690015768	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
103690015769	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
103690015770	Predicted transcriptional regulators [Transcription]; Region: COG1695
103690015771	Transcriptional regulator PadR-like family; Region: PadR; cl17335
103690015772	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
103690015773	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690015774	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690015775	DevC protein; Region: devC; TIGR01185
103690015776	FtsX-like permease family; Region: FtsX; pfam02687
103690015777	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
103690015778	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
103690015779	Walker A/P-loop; other site
103690015780	ATP binding site [chemical binding]; other site
103690015781	Q-loop/lid; other site
103690015782	ABC transporter signature motif; other site
103690015783	Walker B; other site
103690015784	D-loop; other site
103690015785	H-loop/switch region; other site
103690015786	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
103690015787	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690015788	putative active site [active]
103690015789	putative metal binding site [ion binding]; other site
103690015790	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
103690015791	recombination protein RecR; Reviewed; Region: recR; PRK00076
103690015792	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
103690015793	tetramer interface [polypeptide binding]; other site
103690015794	putative active site [active]
103690015795	putative metal-binding site [ion binding]; other site
103690015796	GAF domain; Region: GAF_2; pfam13185
103690015797	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690015798	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690015799	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690015800	DNA binding residues [nucleotide binding]
103690015801	dimerization interface [polypeptide binding]; other site
103690015802	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
103690015803	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015804	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015805	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015806	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690015807	binding surface
103690015808	TPR motif; other site
103690015809	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015810	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690015811	binding surface
103690015812	TPR motif; other site
103690015813	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015814	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015815	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690015816	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
103690015817	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690015818	sucrose synthase; Region: sucr_synth; TIGR02470
103690015819	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
103690015820	putative ADP-binding pocket [chemical binding]; other site
103690015821	Transcriptional regulator [Transcription]; Region: LysR; COG0583
103690015822	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
103690015823	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
103690015824	putative dimerization interface [polypeptide binding]; other site
103690015825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544
103690015826	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
103690015827	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
103690015828	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
103690015829	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
103690015830	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
103690015831	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
103690015832	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
103690015833	DNA binding site [nucleotide binding]
103690015834	active site
103690015835	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
103690015836	Fatty acid desaturase; Region: FA_desaturase; pfam00487
103690015837	Di-iron ligands [ion binding]; other site
103690015838	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690015839	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
103690015840	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
103690015841	nudix motif; other site
103690015842	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
103690015843	Amidinotransferase; Region: Amidinotransf; cl12043
103690015844	Uncharacterized conserved protein [Function unknown]; Region: COG1915
103690015845	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
103690015846	homodimer interface [polypeptide binding]; other site
103690015847	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
103690015848	Uncharacterized conserved protein [Function unknown]; Region: COG5464
103690015849	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
103690015850	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690015851	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690015852	active site
103690015853	Bacterial SH3 domain; Region: SH3_3; pfam08239
103690015854	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
103690015855	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
103690015856	active site
103690015857	metal binding site [ion binding]; metal-binding site
103690015858	CTP synthetase; Validated; Region: pyrG; PRK05380
103690015859	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
103690015860	Catalytic site [active]
103690015861	active site
103690015862	UTP binding site [chemical binding]; other site
103690015863	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
103690015864	active site
103690015865	putative oxyanion hole; other site
103690015866	catalytic triad [active]
103690015867	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
103690015868	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
103690015869	nucleotide binding site [chemical binding]; other site
103690015870	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
103690015871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690015872	dimer interface [polypeptide binding]; other site
103690015873	conserved gate region; other site
103690015874	ABC-ATPase subunit interface; other site
103690015875	SnoaL-like domain; Region: SnoaL_2; pfam12680
103690015876	Tic55 is a 55kDa LLS1-related non-heme iron oxygenase associated with protein transport through the plant inner chloroplast membrane. This domain represents the N-terminal Rieske domain of the Tic55 oxygenase alpha subunit. Tic55 is closely related to...; Region: Rieske_RO_Alpha_Tic55; cd04338
103690015877	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
103690015878	hydrophobic ligand binding site; other site
103690015879	Pheophorbide a oxygenase; Region: PaO; pfam08417
103690015880	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
103690015881	Mgc45594 gene product and other MDR family members; Region: Mgc45594_like; cd08250
103690015882	NADP binding site [chemical binding]; other site
103690015883	dimer interface [polypeptide binding]; other site
103690015884	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
103690015885	Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044
103690015886	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
103690015887	Cyclic amidohydrolases, including hydantoinase, dihydropyrimidinase, allantoinase, and dihydroorotase, are involved in the metabolism of pyrimidines and purines, sharing the property of hydrolyzing the cyclic amide bond of each substrate to the...; Region: Cyclic_amidohydrolases; cd01302
103690015888	active site
103690015889	tetramer interface [polypeptide binding]; other site
103690015890	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
103690015891	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
103690015892	dimer interface [polypeptide binding]; other site
103690015893	motif 1; other site
103690015894	active site
103690015895	motif 2; other site
103690015896	motif 3; other site
103690015897	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
103690015898	anticodon binding site; other site
103690015899	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690015900	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
103690015901	putative active site [active]
103690015902	putative NTP binding site [chemical binding]; other site
103690015903	putative nucleic acid binding site [nucleotide binding]; other site
103690015904	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690015905	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690015906	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
103690015907	Caspase domain; Region: Peptidase_C14; pfam00656
103690015908	5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128
103690015909	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
103690015910	hinge; other site
103690015911	active site
103690015912	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015913	putative active site [active]
103690015914	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015915	putative active site [active]
103690015916	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
103690015917	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
103690015918	NAD(P) binding site [chemical binding]; other site
103690015919	catalytic residues [active]
103690015920	nitrilase; Region: PLN02798
103690015921	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_4; cd07582
103690015922	putative active site [active]
103690015923	catalytic triad [active]
103690015924	putative dimer interface [polypeptide binding]; other site
103690015925	Red chlorophyll catabolite reductase (RCC reductase); Region: RCC_reductase; pfam06405
103690015926	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
103690015927	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690015928	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
103690015929	NAD(P) binding site [chemical binding]; other site
103690015930	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
103690015931	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
103690015932	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690015933	active site
103690015934	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
103690015935	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
103690015936	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
103690015937	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236
103690015938	Predicted membrane protein [Function unknown]; Region: COG4329
103690015939	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
103690015940	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
103690015941	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
103690015942	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690015943	ATP binding site [chemical binding]; other site
103690015944	Walker A motif; other site
103690015945	Walker B motif; other site
103690015946	arginine finger; other site
103690015947	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
103690015948	Protein of unknown function DUF58; Region: DUF58; pfam01882
103690015949	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
103690015950	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
103690015951	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
103690015952	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
103690015953	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
103690015954	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
103690015955	gamma subunit interface [polypeptide binding]; other site
103690015956	epsilon subunit interface [polypeptide binding]; other site
103690015957	LBP interface [polypeptide binding]; other site
103690015958	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
103690015959	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
103690015960	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
103690015961	alpha subunit interaction interface [polypeptide binding]; other site
103690015962	Walker A motif; other site
103690015963	ATP binding site [chemical binding]; other site
103690015964	Walker B motif; other site
103690015965	inhibitor binding site; inhibition site
103690015966	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
103690015967	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
103690015968	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
103690015969	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
103690015970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690015971	dimer interface [polypeptide binding]; other site
103690015972	conserved gate region; other site
103690015973	putative PBP binding loops; other site
103690015974	ABC-ATPase subunit interface; other site
103690015975	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
103690015976	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
103690015977	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
103690015978	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
103690015979	Walker A/P-loop; other site
103690015980	ATP binding site [chemical binding]; other site
103690015981	Q-loop/lid; other site
103690015982	ABC transporter signature motif; other site
103690015983	Walker B; other site
103690015984	D-loop; other site
103690015985	H-loop/switch region; other site
103690015986	TOBE domain; Region: TOBE_2; pfam08402
103690015987	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
103690015988	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
103690015989	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690015990	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
103690015991	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
103690015992	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
103690015993	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690015994	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
103690015995	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
103690015996	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690015997	putative active site [active]
103690015998	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
103690015999	prolyl-tRNA synthetase; Provisional; Region: PRK09194
103690016000	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
103690016001	dimer interface [polypeptide binding]; other site
103690016002	motif 1; other site
103690016003	active site
103690016004	motif 2; other site
103690016005	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
103690016006	putative deacylase active site [active]
103690016007	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
103690016008	active site
103690016009	motif 3; other site
103690016010	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
103690016011	anticodon binding site; other site
103690016012	Spore germination protein [General function prediction only]; Region: COG5401
103690016013	Sporulation and spore germination; Region: Germane; pfam10646
103690016014	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
103690016015	putative DNA binding site [nucleotide binding]; other site
103690016016	putative Zn2+ binding site [ion binding]; other site
103690016017	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
103690016018	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
103690016019	carboxyltransferase (CT) interaction site; other site
103690016020	biotinylation site [posttranslational modification]; other site
103690016021	elongation factor P; Validated; Region: PRK00529
103690016022	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
103690016023	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
103690016024	RNA binding site [nucleotide binding]; other site
103690016025	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
103690016026	RNA binding site [nucleotide binding]; other site
103690016027	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
103690016028	active site
103690016029	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690016030	putative active site [active]
103690016031	thiamine monophosphate kinase; Provisional; Region: PRK05731
103690016032	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
103690016033	ATP binding site [chemical binding]; other site
103690016034	dimerization interface [polypeptide binding]; other site
103690016035	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
103690016036	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
103690016037	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
103690016038	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
103690016039	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
103690016040	active site
103690016041	(T/H)XGH motif; other site
103690016042	Domain of unknown function (DUF3449); Region: DUF3449; pfam11931
103690016043	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
103690016044	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
103690016045	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
103690016046	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
103690016047	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
103690016048	FAD binding domain; Region: FAD_binding_4; pfam01565
103690016049	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
103690016050	hypothetical protein; Validated; Region: PRK00153
103690016051	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
103690016052	Low molecular weight phosphatase family; Region: LMWPc; cd00115
103690016053	active site
103690016054	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690016055	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016056	active site
103690016057	phosphorylation site [posttranslational modification]
103690016058	intermolecular recognition site; other site
103690016059	dimerization interface [polypeptide binding]; other site
103690016060	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690016061	DNA binding residues [nucleotide binding]
103690016062	dimerization interface [polypeptide binding]; other site
103690016063	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
103690016064	SmpB-tmRNA interface; other site
103690016065	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
103690016066	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
103690016067	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690016068	GAF domain; Region: GAF; pfam01590
103690016069	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016070	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016071	dimer interface [polypeptide binding]; other site
103690016072	phosphorylation site [posttranslational modification]
103690016073	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
103690016074	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
103690016075	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
103690016076	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
103690016077	P-loop; other site
103690016078	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
103690016079	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690016080	putative active site [active]
103690016081	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
103690016082	Clp amino terminal domain; Region: Clp_N; pfam02861
103690016083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690016084	Walker A motif; other site
103690016085	ATP binding site [chemical binding]; other site
103690016086	Walker B motif; other site
103690016087	arginine finger; other site
103690016088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690016089	Walker A motif; other site
103690016090	ATP binding site [chemical binding]; other site
103690016091	Walker B motif; other site
103690016092	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
103690016093	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690016094	Tic20-like protein; Region: Tic20; pfam09685
103690016095	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
103690016096	active site
103690016097	dimerization interface [polypeptide binding]; other site
103690016098	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
103690016099	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
103690016100	active site
103690016101	substrate binding site [chemical binding]; other site
103690016102	metal binding site [ion binding]; metal-binding site
103690016103	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690016104	putative protofilament interface [polypeptide binding]; other site
103690016105	nucleotide binding site [chemical binding]; other site
103690016106	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
103690016107	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690016108	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
103690016109	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
103690016110	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
103690016111	Ligand Binding Site [chemical binding]; other site
103690016112	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
103690016113	Domain of unknown function DUF21; Region: DUF21; pfam01595
103690016114	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
103690016115	Transporter associated domain; Region: CorC_HlyC; smart01091
103690016116	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
103690016117	active site
103690016118	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
103690016119	Bacterial Ig-like domain; Region: Big_5; pfam13205
103690016120	MG2 domain; Region: A2M_N; pfam01835
103690016121	Alpha-2-macroglobulin family; Region: A2M; pfam00207
103690016122	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
103690016123	surface patch; other site
103690016124	specificity defining residues; other site
103690016125	Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell envelope biogenesis, outer membrane]; Region: PbpC; COG4953
103690016126	Transglycosylase; Region: Transgly; pfam00912
103690016127	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
103690016128	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
103690016129	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
103690016130	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
103690016131	Probable Catalytic site; other site
103690016132	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
103690016133	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
103690016134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
103690016135	homodimer interface [polypeptide binding]; other site
103690016136	catalytic residue [active]
103690016137	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016138	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016139	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016140	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690016141	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016142	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016143	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016144	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016145	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016146	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016147	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016148	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690016149	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016150	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016151	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016152	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016153	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016154	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016155	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016156	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016157	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016158	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016159	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016160	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016161	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016162	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016163	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016164	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016165	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
103690016166	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
103690016167	Surface antigen; Region: Bac_surface_Ag; pfam01103
103690016168	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
103690016169	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
103690016170	NAD(P) binding site [chemical binding]; other site
103690016171	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
103690016172	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
103690016173	Ligand binding site; other site
103690016174	Putative Catalytic site; other site
103690016175	DXD motif; other site
103690016176	Uncharacterized conserved protein [Function unknown]; Region: COG0398
103690016177	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690016178	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
103690016179	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
103690016180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690016181	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
103690016182	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
103690016183	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
103690016184	Phosphotransferase enzyme family; Region: APH; pfam01636
103690016185	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
103690016186	active site
103690016187	ATP binding site [chemical binding]; other site
103690016188	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
103690016189	DHH family; Region: DHH; pfam01368
103690016190	DHHA1 domain; Region: DHHA1; pfam02272
103690016191	hypothetical protein; Provisional; Region: PRK13686
103690016192	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
103690016193	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690016194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690016195	non-specific DNA binding site [nucleotide binding]; other site
103690016196	salt bridge; other site
103690016197	sequence-specific DNA binding site [nucleotide binding]; other site
103690016198	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
103690016199	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
103690016200	putative active site [active]
103690016201	homotetrameric interface [polypeptide binding]; other site
103690016202	metal binding site [ion binding]; metal-binding site
103690016203	Predicted membrane protein [Function unknown]; Region: COG2119
103690016204	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
103690016205	Predicted membrane protein [Function unknown]; Region: COG2119
103690016206	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
103690016207	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
103690016208	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
103690016209	dimer interface [polypeptide binding]; other site
103690016210	putative functional site; other site
103690016211	putative MPT binding site; other site
103690016212	Caspase domain; Region: Peptidase_C14; pfam00656
103690016213	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
103690016214	ATP-sulfurylase; Region: ATPS; cd00517
103690016215	active site
103690016216	HXXH motif; other site
103690016217	flexible loop; other site
103690016218	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690016219	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
103690016220	putative active site [active]
103690016221	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690016222	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690016223	Walker A/P-loop; other site
103690016224	ATP binding site [chemical binding]; other site
103690016225	Q-loop/lid; other site
103690016226	ABC transporter signature motif; other site
103690016227	Walker B; other site
103690016228	D-loop; other site
103690016229	H-loop/switch region; other site
103690016230	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690016231	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690016232	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690016233	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690016234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016235	active site
103690016236	phosphorylation site [posttranslational modification]
103690016237	intermolecular recognition site; other site
103690016238	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
103690016239	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690016240	CHASE2 domain; Region: CHASE2; pfam05226
103690016241	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
103690016242	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
103690016243	ribonuclease Z; Region: RNase_Z; TIGR02651
103690016244	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
103690016245	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
103690016246	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690016247	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690016248	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690016249	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690016250	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690016251	Uncharacterized conserved protein [Function unknown]; Region: COG1479
103690016252	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
103690016253	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690016254	Amidases related to nicotinamidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PncA; COG1335
103690016255	catalytic triad [active]
103690016256	conserved cis-peptide bond; other site
103690016257	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690016258	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
103690016259	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690016260	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
103690016261	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
103690016262	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
103690016263	protein binding site [polypeptide binding]; other site
103690016264	Protein of unknown function (DUF760); Region: DUF760; pfam05542
103690016265	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
103690016266	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
103690016267	substrate binding site; other site
103690016268	dimer interface; other site
103690016269	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
103690016270	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
103690016271	putative active site [active]
103690016272	Uncharacterized conserved protein [Function unknown]; Region: COG5474
103690016273	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690016274	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690016275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016276	active site
103690016277	phosphorylation site [posttranslational modification]
103690016278	intermolecular recognition site; other site
103690016279	dimerization interface [polypeptide binding]; other site
103690016280	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690016281	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690016282	putative active site [active]
103690016283	heme pocket [chemical binding]; other site
103690016284	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690016285	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
103690016286	putative active site [active]
103690016287	heme pocket [chemical binding]; other site
103690016288	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690016289	putative active site [active]
103690016290	heme pocket [chemical binding]; other site
103690016291	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016292	dimer interface [polypeptide binding]; other site
103690016293	phosphorylation site [posttranslational modification]
103690016294	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016295	ATP binding site [chemical binding]; other site
103690016296	Mg2+ binding site [ion binding]; other site
103690016297	G-X-G motif; other site
103690016298	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016300	active site
103690016301	phosphorylation site [posttranslational modification]
103690016302	intermolecular recognition site; other site
103690016303	dimerization interface [polypeptide binding]; other site
103690016304	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016306	active site
103690016307	phosphorylation site [posttranslational modification]
103690016308	intermolecular recognition site; other site
103690016309	dimerization interface [polypeptide binding]; other site
103690016310	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690016311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016312	active site
103690016313	phosphorylation site [posttranslational modification]
103690016314	intermolecular recognition site; other site
103690016315	dimerization interface [polypeptide binding]; other site
103690016316	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690016317	DNA binding site [nucleotide binding]
103690016318	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690016319	putative binding surface; other site
103690016320	active site
103690016321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
103690016322	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
103690016323	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
103690016324	metal binding site [ion binding]; metal-binding site
103690016325	active site
103690016326	I-site; other site
103690016327	Protein of unknown function (DUF760); Region: DUF760; pfam05542
103690016328	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
103690016329	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
103690016330	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
103690016331	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
103690016332	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016333	S-adenosylmethionine binding site [chemical binding]; other site
103690016334	Uncharacterized conserved protein [Function unknown]; Region: COG2442
103690016335	short chain dehydrogenase; Provisional; Region: PRK06701
103690016336	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
103690016337	NAD binding site [chemical binding]; other site
103690016338	metal binding site [ion binding]; metal-binding site
103690016339	active site
103690016340	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
103690016341	MgtE intracellular N domain; Region: MgtE_N; smart00924
103690016342	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
103690016343	Divalent cation transporter; Region: MgtE; pfam01769
103690016344	mercuric reductase; Validated; Region: PRK06370
103690016345	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690016346	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
103690016347	Uncharacterized conserved protein [Function unknown]; Region: COG0398
103690016348	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
103690016349	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690016350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016351	active site
103690016352	phosphorylation site [posttranslational modification]
103690016353	intermolecular recognition site; other site
103690016354	dimerization interface [polypeptide binding]; other site
103690016355	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690016356	DNA binding site [nucleotide binding]
103690016357	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016358	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
103690016359	dimerization interface [polypeptide binding]; other site
103690016360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016361	dimer interface [polypeptide binding]; other site
103690016362	phosphorylation site [posttranslational modification]
103690016363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016364	ATP binding site [chemical binding]; other site
103690016365	Mg2+ binding site [ion binding]; other site
103690016366	G-X-G motif; other site
103690016367	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
103690016368	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
103690016369	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
103690016370	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
103690016371	active site
103690016372	substrate binding site [chemical binding]; other site
103690016373	ATP binding site [chemical binding]; other site
103690016374	Phosphotransferase enzyme family; Region: APH; pfam01636
103690016375	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
103690016376	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690016377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690016378	Walker A/P-loop; other site
103690016379	ATP binding site [chemical binding]; other site
103690016380	Q-loop/lid; other site
103690016381	ABC transporter signature motif; other site
103690016382	Walker B; other site
103690016383	D-loop; other site
103690016384	H-loop/switch region; other site
103690016385	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016386	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690016387	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
103690016388	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
103690016389	putative ADP-binding pocket [chemical binding]; other site
103690016390	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
103690016391	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690016392	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
103690016393	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690016394	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
103690016395	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
103690016396	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690016397	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
103690016398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690016399	Walker A/P-loop; other site
103690016400	ATP binding site [chemical binding]; other site
103690016401	Q-loop/lid; other site
103690016402	ABC transporter signature motif; other site
103690016403	Walker B; other site
103690016404	D-loop; other site
103690016405	H-loop/switch region; other site
103690016406	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
103690016407	catalytic core [active]
103690016408	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
103690016409	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
103690016410	putative ADP-binding pocket [chemical binding]; other site
103690016411	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
103690016412	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
103690016413	putative ADP-binding pocket [chemical binding]; other site
103690016414	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
103690016415	active site
103690016416	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
103690016417	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690016418	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
103690016419	alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902
103690016420	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
103690016421	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690016422	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690016423	putative active site [active]
103690016424	putative NTP binding site [chemical binding]; other site
103690016425	putative nucleic acid binding site [nucleotide binding]; other site
103690016426	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
103690016427	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690016428	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690016429	active site
103690016430	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690016431	Probable transposase; Region: OrfB_IS605; pfam01385
103690016432	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690016433	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690016434	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690016435	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690016436	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
103690016437	PAS domain S-box; Region: sensory_box; TIGR00229
103690016438	PAS fold; Region: PAS_4; pfam08448
103690016439	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690016440	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690016441	PAS fold; Region: PAS_4; pfam08448
103690016442	PAS domain S-box; Region: sensory_box; TIGR00229
103690016443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690016444	putative active site [active]
103690016445	heme pocket [chemical binding]; other site
103690016446	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690016447	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690016448	GAF domain; Region: GAF; pfam01590
103690016449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016451	dimer interface [polypeptide binding]; other site
103690016452	phosphorylation site [posttranslational modification]
103690016453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016454	ATP binding site [chemical binding]; other site
103690016455	Mg2+ binding site [ion binding]; other site
103690016456	G-X-G motif; other site
103690016457	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690016458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016459	active site
103690016460	phosphorylation site [posttranslational modification]
103690016461	intermolecular recognition site; other site
103690016462	dimerization interface [polypeptide binding]; other site
103690016463	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
103690016464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
103690016465	DoxX-like family; Region: DoxX_3; pfam13781
103690016466	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
103690016467	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
103690016468	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690016469	ATP binding site [chemical binding]; other site
103690016470	putative Mg++ binding site [ion binding]; other site
103690016471	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690016472	nucleotide binding region [chemical binding]; other site
103690016473	ATP-binding site [chemical binding]; other site
103690016474	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
103690016475	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
103690016476	Domain of unknown function DUF21; Region: DUF21; pfam01595
103690016477	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
103690016478	Transporter associated domain; Region: CorC_HlyC; smart01091
103690016479	Predicted membrane protein [Function unknown]; Region: COG1981
103690016480	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690016481	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
103690016482	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690016483	putative active site [active]
103690016484	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
103690016485	Chain length determinant protein; Region: Wzz; pfam02706
103690016486	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
103690016487	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
103690016488	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016489	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
103690016490	Homeodomain-like domain; Region: HTH_23; pfam13384
103690016491	Winged helix-turn helix; Region: HTH_29; pfam13551
103690016492	Homeodomain-like domain; Region: HTH_32; pfam13565
103690016493	DDE superfamily endonuclease; Region: DDE_3; pfam13358
103690016494	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
103690016495	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
103690016496	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
103690016497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016498	S-adenosylmethionine binding site [chemical binding]; other site
103690016499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
103690016500	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
103690016501	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
103690016502	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016503	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
103690016504	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016505	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690016506	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016507	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
103690016508	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016509	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
103690016510	putative ADP-binding pocket [chemical binding]; other site
103690016511	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
103690016512	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
103690016513	putative metal binding site; other site
103690016514	Methyltransferase domain; Region: Methyltransf_31; pfam13847
103690016515	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016516	S-adenosylmethionine binding site [chemical binding]; other site
103690016517	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
103690016518	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640
103690016519	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690016520	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690016521	putative active site [active]
103690016522	cyanosortase-associated protein; Region: cyanosort_assoc; TIGR04153
103690016523	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
103690016524	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
103690016525	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
103690016526	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
103690016527	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
103690016528	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
103690016529	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
103690016530	RNA binding site [nucleotide binding]; other site
103690016531	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016532	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016533	active site
103690016534	phosphorylation site [posttranslational modification]
103690016535	intermolecular recognition site; other site
103690016536	dimerization interface [polypeptide binding]; other site
103690016537	GAF domain; Region: GAF; pfam01590
103690016538	GAF domain; Region: GAF_2; pfam13185
103690016539	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
103690016540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016541	S-adenosylmethionine binding site [chemical binding]; other site
103690016542	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
103690016543	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
103690016544	Sodium Bile acid symporter family; Region: SBF; cl17470
103690016545	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
103690016546	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
103690016547	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
103690016548	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
103690016549	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
103690016550	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690016551	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
103690016552	Lumazine binding domain; Region: Lum_binding; pfam00677
103690016553	Lumazine binding domain; Region: Lum_binding; pfam00677
103690016554	Uncharacterized conserved protein [Function unknown]; Region: COG1259
103690016555	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
103690016556	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
103690016557	active site
103690016558	catalytic tetrad [active]
103690016559	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
103690016560	light-harvesting-like protein 3; Provisional; Region: PLN00014
103690016561	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
103690016562	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690016563	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690016564	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690016565	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690016566	DNA binding residues [nucleotide binding]
103690016567	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
103690016568	Fasciclin domain; Region: Fasciclin; pfam02469
103690016569	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
103690016570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016571	Mg2+ binding site [ion binding]; other site
103690016572	G-X-G motif; other site
103690016573	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
103690016574	anchoring element; other site
103690016575	dimer interface [polypeptide binding]; other site
103690016576	ATP binding site [chemical binding]; other site
103690016577	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
103690016578	active site
103690016579	putative metal-binding site [ion binding]; other site
103690016580	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
103690016581	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
103690016582	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
103690016583	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690016584	putative active site [active]
103690016585	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
103690016586	FAD binding domain; Region: FAD_binding_4; pfam01565
103690016587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
103690016588	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
103690016589	PAS fold; Region: PAS_4; pfam08448
103690016590	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
103690016591	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690016592	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
103690016593	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016594	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016595	dimer interface [polypeptide binding]; other site
103690016596	phosphorylation site [posttranslational modification]
103690016597	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016598	ATP binding site [chemical binding]; other site
103690016599	Mg2+ binding site [ion binding]; other site
103690016600	G-X-G motif; other site
103690016601	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
103690016602	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
103690016603	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
103690016604	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
103690016605	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
103690016606	HicB family; Region: HicB; pfam05534
103690016607	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
103690016608	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690016609	active site
103690016610	ATP binding site [chemical binding]; other site
103690016611	substrate binding site [chemical binding]; other site
103690016612	activation loop (A-loop); other site
103690016613	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690016614	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690016615	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
103690016616	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
103690016617	dimer interface [polypeptide binding]; other site
103690016618	conserved gate region; other site
103690016619	putative PBP binding loops; other site
103690016620	ABC-ATPase subunit interface; other site
103690016621	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
103690016622	dinuclear metal binding motif [ion binding]; other site
103690016623	acyl-ACP reductase; Provisional; Region: PRK14982
103690016624	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
103690016625	NAD(P) binding pocket [chemical binding]; other site
103690016626	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
103690016627	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
103690016628	short chain dehydrogenase; Provisional; Region: PRK07454
103690016629	classical (c) SDRs; Region: SDR_c; cd05233
103690016630	NAD(P) binding site [chemical binding]; other site
103690016631	active site
103690016632	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
103690016633	homodecamer interface [polypeptide binding]; other site
103690016634	GTP cyclohydrolase I; Provisional; Region: PLN03044
103690016635	active site
103690016636	putative catalytic site residues [active]
103690016637	zinc binding site [ion binding]; other site
103690016638	GTP-CH-I/GFRP interaction surface; other site
103690016639	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
103690016640	active site
103690016641	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
103690016642	photosystem I reaction center subunit X-like protein; Reviewed; Region: PRK13216
103690016643	Uncharacterized conserved protein [Function unknown]; Region: COG3391
103690016644	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
103690016645	CpeS-like protein; Region: CpeS; pfam09367
103690016646	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
103690016647	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690016648	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
103690016649	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
103690016650	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
103690016651	putative NADP binding site [chemical binding]; other site
103690016652	putative substrate binding site [chemical binding]; other site
103690016653	active site
103690016654	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
103690016655	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
103690016656	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
103690016657	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
103690016658	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
103690016659	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
103690016660	putative homodimer interface [polypeptide binding]; other site
103690016661	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
103690016662	heterodimer interface [polypeptide binding]; other site
103690016663	homodimer interface [polypeptide binding]; other site
103690016664	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
103690016665	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
103690016666	23S rRNA interface [nucleotide binding]; other site
103690016667	L7/L12 interface [polypeptide binding]; other site
103690016668	putative thiostrepton binding site; other site
103690016669	L25 interface [polypeptide binding]; other site
103690016670	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
103690016671	mRNA/rRNA interface [nucleotide binding]; other site
103690016672	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
103690016673	23S rRNA interface [nucleotide binding]; other site
103690016674	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
103690016675	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
103690016676	peripheral dimer interface [polypeptide binding]; other site
103690016677	core dimer interface [polypeptide binding]; other site
103690016678	L10 interface [polypeptide binding]; other site
103690016679	L11 interface [polypeptide binding]; other site
103690016680	putative EF-Tu interaction site [polypeptide binding]; other site
103690016681	putative EF-G interaction site [polypeptide binding]; other site
103690016682	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690016683	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
103690016684	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690016685	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
103690016686	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
103690016687	NAD(P) binding site [chemical binding]; other site
103690016688	putative active site [active]
103690016689	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
103690016690	putative catalytic site [active]
103690016691	putative phosphate binding site [ion binding]; other site
103690016692	active site
103690016693	metal binding site A [ion binding]; metal-binding site
103690016694	DNA binding site [nucleotide binding]
103690016695	putative AP binding site [nucleotide binding]; other site
103690016696	putative metal binding site B [ion binding]; other site
103690016697	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016698	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
103690016699	putative ADP-binding pocket [chemical binding]; other site
103690016700	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016702	active site
103690016703	phosphorylation site [posttranslational modification]
103690016704	intermolecular recognition site; other site
103690016705	dimerization interface [polypeptide binding]; other site
103690016706	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
103690016707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016708	dimer interface [polypeptide binding]; other site
103690016709	phosphorylation site [posttranslational modification]
103690016710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016711	ATP binding site [chemical binding]; other site
103690016712	Mg2+ binding site [ion binding]; other site
103690016713	G-X-G motif; other site
103690016714	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690016715	CHASE2 domain; Region: CHASE2; pfam05226
103690016716	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690016717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016718	dimer interface [polypeptide binding]; other site
103690016719	phosphorylation site [posttranslational modification]
103690016720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016721	ATP binding site [chemical binding]; other site
103690016722	Mg2+ binding site [ion binding]; other site
103690016723	G-X-G motif; other site
103690016724	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016726	active site
103690016727	phosphorylation site [posttranslational modification]
103690016728	intermolecular recognition site; other site
103690016729	dimerization interface [polypeptide binding]; other site
103690016730	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690016731	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690016732	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690016733	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
103690016734	PRC-barrel domain; Region: PRC; pfam05239
103690016735	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
103690016736	S-layer homology domain; Region: SLH; pfam00395
103690016737	S-layer homology domain; Region: SLH; pfam00395
103690016738	S-layer homology domain; Region: SLH; pfam00395
103690016739	Predicted membrane protein [Function unknown]; Region: COG1808
103690016740	Ion transport protein; Region: Ion_trans; pfam00520
103690016741	Ion channel; Region: Ion_trans_2; pfam07885
103690016742	Predicted membrane protein [Function unknown]; Region: COG4325
103690016743	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
103690016744	Domain of unknown function DUF20; Region: UPF0118; pfam01594
103690016745	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
103690016746	na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844
103690016747	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
103690016748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016749	active site
103690016750	phosphorylation site [posttranslational modification]
103690016751	intermolecular recognition site; other site
103690016752	dimerization interface [polypeptide binding]; other site
103690016753	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
103690016754	DNA binding site [nucleotide binding]
103690016755	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
103690016756	putative binding surface; other site
103690016757	active site
103690016758	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690016759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016760	active site
103690016761	phosphorylation site [posttranslational modification]
103690016762	intermolecular recognition site; other site
103690016763	dimerization interface [polypeptide binding]; other site
103690016764	Transglycosylase; Region: Transgly; pfam00912
103690016765	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
103690016766	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
103690016767	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
103690016768	Transglycosylase; Region: Transgly; pfam00912
103690016769	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
103690016770	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
103690016771	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
103690016772	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
103690016773	putative active site [active]
103690016774	heme pocket [chemical binding]; other site
103690016775	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
103690016776	dimer interface [polypeptide binding]; other site
103690016777	phosphorylation site [posttranslational modification]
103690016778	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690016779	ATP binding site [chemical binding]; other site
103690016780	Mg2+ binding site [ion binding]; other site
103690016781	G-X-G motif; other site
103690016782	Response regulator receiver domain; Region: Response_reg; pfam00072
103690016783	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016784	active site
103690016785	phosphorylation site [posttranslational modification]
103690016786	intermolecular recognition site; other site
103690016787	dimerization interface [polypeptide binding]; other site
103690016788	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
103690016789	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
103690016790	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
103690016791	trimer interface [polypeptide binding]; other site
103690016792	active site
103690016793	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
103690016794	catalytic site [active]
103690016795	PRC-barrel domain; Region: PRC; pfam05239
103690016796	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
103690016797	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
103690016798	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
103690016799	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
103690016800	NAD binding site [chemical binding]; other site
103690016801	catalytic Zn binding site [ion binding]; other site
103690016802	structural Zn binding site [ion binding]; other site
103690016803	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
103690016804	dimerization interface [polypeptide binding]; other site
103690016805	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
103690016806	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
103690016807	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
103690016808	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
103690016809	active site
103690016810	metal binding site [ion binding]; metal-binding site
103690016811	hexamer interface [polypeptide binding]; other site
103690016812	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
103690016813	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690016814	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
103690016815	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
103690016816	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
103690016817	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690016818	active site
103690016819	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
103690016820	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
103690016821	active site
103690016822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
103690016823	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
103690016824	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690016825	NAD(P) binding site [chemical binding]; other site
103690016826	active site
103690016827	DevC protein; Region: devC; TIGR01185
103690016828	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
103690016829	FtsX-like permease family; Region: FtsX; pfam02687
103690016830	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
103690016831	Peptidase family M23; Region: Peptidase_M23; pfam01551
103690016832	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690016833	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
103690016834	ParB-like nuclease domain; Region: ParB; smart00470
103690016835	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
103690016836	DNA methylase; Region: N6_N4_Mtase; cl17433
103690016837	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690016838	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690016839	active site
103690016840	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
103690016841	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
103690016842	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
103690016843	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
103690016844	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
103690016845	putative NADP binding site [chemical binding]; other site
103690016846	active site
103690016847	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
103690016848	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
103690016849	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690016850	active site
103690016851	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
103690016852	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
103690016853	active site
103690016854	Acyl transferase domain; Region: Acyl_transf_1; cl08282
103690016855	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
103690016856	FMN binding site [chemical binding]; other site
103690016857	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
103690016858	substrate binding site [chemical binding]; other site
103690016859	putative catalytic residue [active]
103690016860	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
103690016861	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
103690016862	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
103690016863	putative NAD(P) binding site [chemical binding]; other site
103690016864	active site
103690016865	putative substrate binding site [chemical binding]; other site
103690016866	HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932
103690016867	putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730
103690016868	putative NAD(P) binding site [chemical binding]; other site
103690016869	active site
103690016870	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
103690016871	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
103690016872	Uncharacterized conserved protein [Function unknown]; Region: COG1262
103690016873	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
103690016874	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
103690016875	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
103690016876	putative ligand binding site [chemical binding]; other site
103690016877	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
103690016878	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
103690016879	Walker A/P-loop; other site
103690016880	ATP binding site [chemical binding]; other site
103690016881	Q-loop/lid; other site
103690016882	ABC transporter signature motif; other site
103690016883	Walker B; other site
103690016884	D-loop; other site
103690016885	H-loop/switch region; other site
103690016886	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
103690016887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
103690016888	AAA domain; Region: AAA_33; pfam13671
103690016889	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
103690016890	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
103690016891	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
103690016892	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
103690016893	TM-ABC transporter signature motif; other site
103690016894	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
103690016895	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
103690016896	TM-ABC transporter signature motif; other site
103690016897	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690016898	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016899	S-adenosylmethionine binding site [chemical binding]; other site
103690016900	Uncharacterized conserved protein [Function unknown]; Region: COG2128
103690016901	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
103690016902	CDS is reported in Acc# AP003581; ORF_ID:all0001
103690016903	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
103690016904	putative dimer interface [polypeptide binding]; other site
103690016905	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690016906	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
103690016907	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690016908	Mg binding site [ion binding]; other site
103690016909	nucleotide binding site [chemical binding]; other site
103690016910	putative protofilament interface [polypeptide binding]; other site
103690016911	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
103690016912	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
103690016913	MULE transposase domain; Region: MULE; pfam10551
103690016914	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
103690016915	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
103690016916	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
103690016917	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
103690016918	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690016919	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690016920	S-adenosylmethionine binding site [chemical binding]; other site
103690016921	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
103690016922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016923	active site
103690016924	phosphorylation site [posttranslational modification]
103690016925	intermolecular recognition site; other site
103690016926	dimerization interface [polypeptide binding]; other site
103690016927	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
103690016928	Virulence-associated protein E; Region: VirE; pfam05272
103690016929	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690016930	Mg binding site [ion binding]; other site
103690016931	nucleotide binding site [chemical binding]; other site
103690016932	putative protofilament interface [polypeptide binding]; other site
103690016933	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
103690016934	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
103690016935	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
103690016936	Walker A motif; other site
103690016937	ATP binding site [chemical binding]; other site
103690016938	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690016939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016940	active site
103690016941	phosphorylation site [posttranslational modification]
103690016942	intermolecular recognition site; other site
103690016943	dimerization interface [polypeptide binding]; other site
103690016944	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690016945	DNA binding residues [nucleotide binding]
103690016946	dimerization interface [polypeptide binding]; other site
103690016947	putative lyase; Provisional; Region: PRK09687
103690016948	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690016949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690016950	active site
103690016951	phosphorylation site [posttranslational modification]
103690016952	intermolecular recognition site; other site
103690016953	dimerization interface [polypeptide binding]; other site
103690016954	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690016955	DNA binding residues [nucleotide binding]
103690016956	dimerization interface [polypeptide binding]; other site
103690016957	Phospholipid methyltransferase; Region: PEMT; cl17370
103690016958	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690016959	Uncharacterized protein involved in ubiquinone biosynthesis [Coenzyme metabolism]; Region: COQ4; COG5031
103690016960	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690016961	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690016962	structural tetrad; other site
103690016963	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
103690016964	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
103690016965	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690016966	active site
103690016967	catalytic residues [active]
103690016968	DNA binding site [nucleotide binding]
103690016969	Int/Topo IB signature motif; other site
103690016970	Protein of unknown function DUF262; Region: DUF262; pfam03235
103690016971	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
103690016972	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690016973	active site
103690016974	HNH endonuclease; Region: HNH_4; pfam13395
103690016975	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690016976	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
103690016977	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
103690016978	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690016979	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690016980	putative active site [active]
103690016981	putative NTP binding site [chemical binding]; other site
103690016982	putative nucleic acid binding site [nucleotide binding]; other site
103690016983	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
103690016984	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690016985	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690016986	active site
103690016987	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690016988	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690016989	P-loop; other site
103690016990	Magnesium ion binding site [ion binding]; other site
103690016991	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690016992	Magnesium ion binding site [ion binding]; other site
103690016993	tRNA-like structure
103690016994	tRNA-like structure
103690016995	tRNA-like structure
103690016996	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690016997	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690016998	active site
103690016999	MULE transposase domain; Region: MULE; pfam10551
103690017000	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690017001	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690017002	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690017003	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017004	HTH domain; Region: HTH_22; pfam13309
103690017005	MULE transposase domain; Region: MULE; pfam10551
103690017006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017007	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690017008	hypothetical protein; Reviewed; Region: PRK12275
103690017009	four helix bundle protein; Region: TIGR02436
103690017010	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017011	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690017012	Probable transposase; Region: OrfB_IS605; pfam01385
103690017013	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690017014	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690017015	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690017016	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
103690017017	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690017018	ATP-grasp ribosomal peptide maturase, MvdC family; Region: ATPgraspMvdC; TIGR04185
103690017019	ATP-grasp domain; Region: ATP-grasp_4; cl17255
103690017020	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
103690017021	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690017022	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
103690017023	putative active site [active]
103690017024	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690017025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690017026	Walker A/P-loop; other site
103690017027	ATP binding site [chemical binding]; other site
103690017028	Q-loop/lid; other site
103690017029	ABC transporter signature motif; other site
103690017030	Walker B; other site
103690017031	D-loop; other site
103690017032	H-loop/switch region; other site
103690017033	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
103690017034	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690017035	GAF domain; Region: GAF; cl17456
103690017036	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690017037	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690017038	DNA binding residues [nucleotide binding]
103690017039	dimerization interface [polypeptide binding]; other site
103690017040	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5331
103690017041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
103690017042	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
103690017043	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
103690017044	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
103690017045	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
103690017046	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
103690017047	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
103690017048	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
103690017049	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
103690017050	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
103690017051	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690017052	ATP binding site [chemical binding]; other site
103690017053	putative Mg++ binding site [ion binding]; other site
103690017054	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690017055	nucleotide binding region [chemical binding]; other site
103690017056	ATP-binding site [chemical binding]; other site
103690017057	RRXRR protein; Region: RRXRR; pfam14239
103690017058	CAAX protease self-immunity; Region: Abi; pfam02517
103690017059	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
103690017060	active site
103690017061	metal binding site [ion binding]; metal-binding site
103690017062	interdomain interaction site; other site
103690017063	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690017064	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690017065	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690017066	non-specific DNA binding site [nucleotide binding]; other site
103690017067	salt bridge; other site
103690017068	sequence-specific DNA binding site [nucleotide binding]; other site
103690017069	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
103690017070	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
103690017071	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690017072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690017073	Walker A motif; other site
103690017074	ATP binding site [chemical binding]; other site
103690017075	Walker B motif; other site
103690017076	arginine finger; other site
103690017077	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
103690017078	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
103690017079	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
103690017080	AAA-like domain; Region: AAA_10; pfam12846
103690017081	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
103690017082	Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706
103690017083	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
103690017084	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
103690017085	DNA binding site [nucleotide binding]
103690017086	AAA domain; Region: AAA_30; pfam13604
103690017087	Family description; Region: UvrD_C_2; pfam13538
103690017088	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690017089	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
103690017090	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690017091	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
103690017092	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
103690017093	motif II; other site
103690017094	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690017095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690017096	active site
103690017097	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
103690017098	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
103690017099	active site
103690017100	DNA binding site [nucleotide binding]
103690017101	Int/Topo IB signature motif; other site
103690017102	sodium/hydrogen exchanger 3; Region: b_cpa1; TIGR00840
103690017103	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690017104	Mg binding site [ion binding]; other site
103690017105	nucleotide binding site [chemical binding]; other site
103690017106	putative protofilament interface [polypeptide binding]; other site
103690017107	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
103690017108	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690017109	P-loop; other site
103690017110	Magnesium ion binding site [ion binding]; other site
103690017111	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
103690017112	Magnesium ion binding site [ion binding]; other site
103690017113	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
103690017114	ParB-like nuclease domain; Region: ParBc; pfam02195
103690017115	recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341
103690017116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017117	Probable transposase; Region: OrfB_IS605; pfam01385
103690017118	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017119	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
103690017120	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690017121	Methyltransferase domain; Region: Methyltransf_26; pfam13659
103690017122	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
103690017123	Helicase_C-like; Region: Helicase_C_4; pfam13871
103690017124	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
103690017125	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
103690017126	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
103690017127	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
103690017128	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
103690017129	AIPR protein; Region: AIPR; pfam10592
103690017130	HNH endonuclease; Region: HNH_3; pfam13392
103690017131	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690017132	structural tetrad; other site
103690017133	PQQ-like domain; Region: PQQ_2; pfam13360
103690017134	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690017135	putative active site [active]
103690017136	AIPR protein; Region: AIPR; pfam10592
103690017137	MULE transposase domain; Region: MULE; pfam10551
103690017138	AIPR protein; Region: AIPR; pfam10592
103690017139	MULE transposase domain; Region: MULE; pfam10551
103690017140	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690017141	putative active site [active]
103690017142	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
103690017143	HNH endonuclease; Region: HNH_3; pfam13392
103690017144	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
103690017145	PEP-CTERM protein sorting domain, cyanobacterial subclass; Region: cyano_PEP; TIGR04155
103690017146	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
103690017147	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
103690017148	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690017149	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690017150	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690017151	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690017152	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690017153	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690017154	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690017155	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690017156	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690017157	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690017158	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
103690017159	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690017160	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017161	Cadherin-like repeat domain of alpha dystroglycan; Region: Dystroglycan_repeat; cd11303
103690017162	Cadherin-like repeat domain of alpha dystroglycan; Region: Dystroglycan_repeat; cd11303
103690017163	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017164	Cadherin-like repeat domain of alpha dystroglycan; Region: Dystroglycan_repeat; cd11303
103690017165	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017166	Cadherin repeat-like domain; Region: CA_like; cl15786
103690017167	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017168	Ca2+ binding site [ion binding]; other site
103690017169	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017170	Cadherin repeat-like domain; Region: CA_like; cl15786
103690017171	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
103690017172	AAA ATPase domain; Region: AAA_16; pfam13191
103690017173	NACHT domain; Region: NACHT; pfam05729
103690017174	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
103690017175	WD40 repeats; Region: WD40; smart00320
103690017176	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690017177	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690017178	structural tetrad; other site
103690017179	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
103690017180	structural tetrad; other site
103690017181	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
103690017182	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
103690017183	Mrr N-terminal domain; Region: Mrr_N; pfam14338
103690017184	Restriction endonuclease; Region: Mrr_cat; pfam04471
103690017185	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
103690017186	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
103690017187	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
103690017188	BRO family, N-terminal domain; Region: Bro-N; pfam02498
103690017189	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
103690017190	AAA domain; Region: AAA_23; pfam13476
103690017191	Predicted transcriptional regulator [Transcription]; Region: COG3655
103690017192	non-specific DNA binding site [nucleotide binding]; other site
103690017193	salt bridge; other site
103690017194	sequence-specific DNA binding site [nucleotide binding]; other site
103690017195	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
103690017196	DNA binding residues [nucleotide binding]
103690017197	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690017198	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
103690017199	DNA binding residues [nucleotide binding]
103690017200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017201	Probable transposase; Region: OrfB_IS605; pfam01385
103690017202	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
103690017203	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
103690017204	catalytic residues [active]
103690017205	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017206	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690017207	Probable transposase; Region: OrfB_IS605; pfam01385
103690017208	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017209	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690017210	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
103690017211	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
103690017212	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017213	Probable transposase; Region: OrfB_IS605; pfam01385
103690017214	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017215	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
103690017216	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
103690017217	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
103690017218	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690017219	ATP binding site [chemical binding]; other site
103690017220	putative Mg++ binding site [ion binding]; other site
103690017221	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690017222	nucleotide binding region [chemical binding]; other site
103690017223	ATP-binding site [chemical binding]; other site
103690017224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017225	Probable transposase; Region: OrfB_IS605; pfam01385
103690017226	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017227	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
103690017228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017229	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690017230	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
103690017231	putative di-iron ligands [ion binding]; other site
103690017232	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246
103690017233	putative dimer interface [polypeptide binding]; other site
103690017234	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690017235	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
103690017236	Uncharacterized conserved protein [Function unknown]; Region: COG3506
103690017237	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
103690017238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
103690017239	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
103690017240	MarR family; Region: MarR; pfam01047
103690017241	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
103690017242	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690017243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690017244	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690017245	Coenzyme A binding pocket [chemical binding]; other site
103690017246	Uncharacterized conserved protein [Function unknown]; Region: COG4279
103690017247	SWIM zinc finger; Region: SWIM; pfam04434
103690017248	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
103690017249	SNF2 Helicase protein; Region: DUF3670; pfam12419
103690017250	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
103690017251	ATP binding site [chemical binding]; other site
103690017252	putative Mg++ binding site [ion binding]; other site
103690017253	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
103690017254	nucleotide binding region [chemical binding]; other site
103690017255	ATP-binding site [chemical binding]; other site
103690017256	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
103690017257	putative active site [active]
103690017258	Uncharacterized conserved protein [Function unknown]; Region: COG1434
103690017259	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
103690017260	putative active site [active]
103690017261	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
103690017262	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690017263	Coenzyme A binding pocket [chemical binding]; other site
103690017264	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
103690017265	MULE transposase domain; Region: MULE; pfam10551
103690017266	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
103690017267	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
103690017268	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690017269	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
103690017270	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
103690017271	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
103690017272	DNA binding residues [nucleotide binding]
103690017273	Helix-turn-helix domain; Region: HTH_17; cl17695
103690017274	thioesterase domain, putative; Region: yiiD_Cterm; TIGR02447
103690017275	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
103690017276	active site pocket [active]
103690017277	oxyanion hole [active]
103690017278	catalytic triad [active]
103690017279	active site nucleophile [active]
103690017280	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690017281	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
103690017282	structural tetrad; other site
103690017283	FOG: WD40 repeat [General function prediction only]; Region: COG2319
103690017284	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
103690017285	structural tetrad; other site
103690017286	AIPR protein; Region: AIPR; pfam10592
103690017287	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
103690017288	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
103690017289	Walker A/P-loop; other site
103690017290	ATP binding site [chemical binding]; other site
103690017291	Q-loop/lid; other site
103690017292	ABC transporter signature motif; other site
103690017293	Walker B; other site
103690017294	D-loop; other site
103690017295	H-loop/switch region; other site
103690017296	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
103690017297	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
103690017298	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
103690017299	Mg binding site [ion binding]; other site
103690017300	nucleotide binding site [chemical binding]; other site
103690017301	putative protofilament interface [polypeptide binding]; other site
103690017302	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
103690017303	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
103690017304	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
103690017305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690017306	Walker A motif; other site
103690017307	ATP binding site [chemical binding]; other site
103690017308	Walker B motif; other site
103690017309	arginine finger; other site
103690017310	Uncharacterized conserved protein [Function unknown]; Region: COG1430
103690017311	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
103690017312	Restriction endonuclease; Region: Mrr_cat; pfam04471
103690017313	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
103690017314	active site
103690017315	catalytic residues [active]
103690017316	DNA binding site [nucleotide binding]
103690017317	Int/Topo IB signature motif; other site
103690017318	N-terminal domain of eIF2D, malignant T cell-amplified sequence 1 and related proteins; Region: eIF2D_N_like; cl16921
103690017319	AAA-like domain; Region: AAA_10; pfam12846
103690017320	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
103690017321	Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505
103690017322	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
103690017323	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
103690017324	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
103690017325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
103690017326	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
103690017327	ATP binding site [chemical binding]; other site
103690017328	Mg2+ binding site [ion binding]; other site
103690017329	G-X-G motif; other site
103690017330	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
103690017331	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
103690017332	active site
103690017333	phosphorylation site [posttranslational modification]
103690017334	intermolecular recognition site; other site
103690017335	dimerization interface [polypeptide binding]; other site
103690017336	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
103690017337	DNA binding residues [nucleotide binding]
103690017338	dimerization interface [polypeptide binding]; other site
103690017339	AAA domain; Region: AAA_17; pfam13207
103690017340	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
103690017341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017342	Probable transposase; Region: OrfB_IS605; pfam01385
103690017343	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
103690017345	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
103690017346	Walker A motif; other site
103690017347	ATP binding site [chemical binding]; other site
103690017348	Walker B motif; other site
103690017349	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017350	Probable transposase; Region: OrfB_IS605; pfam01385
103690017351	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017352	Catalytic domain of Protein Kinases; Region: PKc; cd00180
103690017353	active site
103690017354	ATP binding site [chemical binding]; other site
103690017355	substrate binding site [chemical binding]; other site
103690017356	activation loop (A-loop); other site
103690017357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
103690017358	TPR repeat; Region: TPR_11; pfam13414
103690017359	binding surface
103690017360	TPR motif; other site
103690017361	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690017362	TPR motif; other site
103690017363	binding surface
103690017364	TPR repeat; Region: TPR_11; pfam13414
103690017365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690017366	binding surface
103690017367	TPR motif; other site
103690017368	TPR repeat; Region: TPR_11; pfam13414
103690017369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
103690017370	binding surface
103690017371	TPR motif; other site
103690017372	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690017373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690017374	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690017375	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690017376	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
103690017377	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
103690017378	Zn binding site [ion binding]; other site
103690017379	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
103690017380	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690017381	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
103690017382	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690017383	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690017384	putative active site [active]
103690017385	putative NTP binding site [chemical binding]; other site
103690017386	putative nucleic acid binding site [nucleotide binding]; other site
103690017387	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
103690017388	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690017389	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690017390	active site
103690017391	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690017392	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690017393	putative active site [active]
103690017394	putative NTP binding site [chemical binding]; other site
103690017395	putative nucleic acid binding site [nucleotide binding]; other site
103690017396	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
103690017397	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690017398	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690017399	active site
103690017400	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
103690017401	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690017402	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690017403	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
103690017404	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
103690017405	GUN4-like; Region: GUN4; pfam05419
103690017406	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
103690017407	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017408	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690017409	Probable transposase; Region: OrfB_IS605; pfam01385
103690017410	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017411	Transposase IS200 like; Region: Y1_Tnp; pfam01797
103690017412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
103690017413	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
103690017414	S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672
103690017415	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
103690017416	active site
103690017417	phytoene desaturase; Region: crtI_fam; TIGR02734
103690017418	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
103690017419	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
103690017420	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
103690017421	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
103690017422	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
103690017423	active site
103690017424	substrate binding site [chemical binding]; other site
103690017425	Mg2+ binding site [ion binding]; other site
103690017426	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
103690017427	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550
103690017428	MULE transposase domain; Region: MULE; pfam10551
103690017429	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690017430	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690017431	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690017432	cofactor binding site; other site
103690017433	DNA binding site [nucleotide binding]
103690017434	substrate interaction site [chemical binding]; other site
103690017435	ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554
103690017436	replicative DNA helicase; Region: DnaB; TIGR00665
103690017437	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
103690017438	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
103690017439	Walker A motif; other site
103690017440	ATP binding site [chemical binding]; other site
103690017441	Walker B motif; other site
103690017442	DNA binding loops [nucleotide binding]
103690017443	Helix-turn-helix domain; Region: HTH_36; pfam13730
103690017444	RRXRR protein; Region: RRXRR; pfam14239
103690017445	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690017446	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690017447	active site
103690017448	Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145
103690017449	Transcriptional activator, adenine-specific DNA methyltransferase [Signal transduction mechanisms / Transcription]; Region: IME4; COG4725
103690017450	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690017451	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
103690017452	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
103690017453	non-specific DNA binding site [nucleotide binding]; other site
103690017454	salt bridge; other site
103690017455	sequence-specific DNA binding site [nucleotide binding]; other site
103690017456	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
103690017457	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
103690017458	putative active site [active]
103690017459	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690017460	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690017461	Walker A/P-loop; other site
103690017462	ATP binding site [chemical binding]; other site
103690017463	Q-loop/lid; other site
103690017464	ABC transporter signature motif; other site
103690017465	Walker B; other site
103690017466	D-loop; other site
103690017467	H-loop/switch region; other site
103690017468	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
103690017469	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690017470	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690017471	Walker A/P-loop; other site
103690017472	ATP binding site [chemical binding]; other site
103690017473	Q-loop/lid; other site
103690017474	ABC transporter signature motif; other site
103690017475	Walker B; other site
103690017476	D-loop; other site
103690017477	H-loop/switch region; other site
103690017478	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
103690017479	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
103690017480	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690017481	MULE transposase domain; Region: MULE; pfam10551
103690017482	Calx-beta domain; Region: Calx-beta; cl02522
103690017483	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
103690017484	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
103690017485	Calx-beta domain; Region: Calx-beta; pfam03160
103690017486	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
103690017487	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
103690017488	Calx-beta domain; Region: Calx-beta; cl02522
103690017489	CARDB; Region: CARDB; pfam07705
103690017490	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
103690017491	Cna protein B-type domain; Region: Cna_B; pfam05738
103690017492	Calx-beta domain; Region: Calx-beta; cl02522
103690017493	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
103690017494	active site
103690017495	catalytic residues [active]
103690017496	Cadherin repeat-like domain; Region: CA_like; cl15786
103690017497	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017498	Ca2+ binding site [ion binding]; other site
103690017499	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
103690017500	Cadherin repeat-like domain; Region: CA_like; cl15786
103690017501	Ca2+ binding site [ion binding]; other site
103690017502	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690017503	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
103690017504	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017505	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690017506	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
103690017507	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
103690017508	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
103690017509	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
103690017510	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
103690017511	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
103690017512	active site
103690017513	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
103690017514	CHAT domain; Region: CHAT; cl17868
103690017515	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
103690017516	CHASE2 domain; Region: CHASE2; pfam05226
103690017517	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
103690017518	haemagglutination activity domain; Region: Haemagg_act; pfam05860
103690017519	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
103690017520	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
103690017521	carboxyltransferase (CT) interaction site; other site
103690017522	biotinylation site [posttranslational modification]; other site
103690017523	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
103690017524	HlyD family secretion protein; Region: HlyD_3; pfam13437
103690017525	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
103690017526	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
103690017527	ligand binding site [chemical binding]; other site
103690017528	flexible hinge region; other site
103690017529	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
103690017530	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
103690017531	putative active site [active]
103690017532	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
103690017533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
103690017534	Walker A/P-loop; other site
103690017535	ATP binding site [chemical binding]; other site
103690017536	Q-loop/lid; other site
103690017537	ABC transporter signature motif; other site
103690017538	Walker B; other site
103690017539	D-loop; other site
103690017540	H-loop/switch region; other site
103690017541	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
103690017542	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
103690017543	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
103690017544	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690017545	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690017546	Tetratricopeptide repeat; Region: TPR_12; pfam13424
103690017547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
103690017548	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837
103690017549	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
103690017550	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
103690017551	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
103690017552	MULE transposase domain; Region: MULE; pfam10551
103690017553	Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503
103690017554	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017555	Probable transposase; Region: OrfB_IS605; pfam01385
103690017556	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017557	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
103690017558	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
103690017559	Probable transposase; Region: OrfB_IS605; pfam01385
103690017560	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
103690017561	CheB methylesterase; Region: CheB_methylest; pfam01339
103690017562	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
103690017563	methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027
103690017564	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
103690017565	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
103690017566	Catalytic site; other site
103690017567	Excalibur calcium-binding domain; Region: Excalibur; cl05460
103690017568	6-phosphofructokinase; Provisional; Region: PRK14071
103690017569	active site
103690017570	ADP/pyrophosphate binding site [chemical binding]; other site
103690017571	dimerization interface [polypeptide binding]; other site
103690017572	allosteric effector site; other site
103690017573	fructose-1,6-bisphosphate binding site; other site
103690017574	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
103690017575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
103690017576	Coenzyme A binding pocket [chemical binding]; other site
103690017577	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
103690017578	Predicted methyltransferase [General function prediction only]; Region: COG4798
103690017579	Staphylococcal nuclease homologues; Region: SNc; smart00318
103690017580	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
103690017581	Catalytic site; other site
103690017582	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
103690017583	Methyltransferase domain; Region: Methyltransf_23; pfam13489
103690017584	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
103690017585	S-adenosylmethionine binding site [chemical binding]; other site
103690017586	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
103690017587	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
103690017588	pheophorbide a oxygenase; Region: PLN02518
103690017589	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
103690017590	iron-sulfur cluster [ion binding]; other site
103690017591	[2Fe-2S] cluster binding site [ion binding]; other site
103690017592	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017593	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
103690017594	Transposase; Region: DDE_Tnp_ISL3; pfam01610
103690017595	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
103690017596	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
103690017597	nudix motif; other site
103690017598	Uncharacterized conserved protein [Function unknown]; Region: COG1723
103690017599	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
103690017600	Family description; Region: UvrD_C_2; pfam13538
103690017601	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
103690017602	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
103690017603	putative C-terminal domain interface [polypeptide binding]; other site
103690017604	putative GSH binding site (G-site) [chemical binding]; other site
103690017605	putative dimer interface [polypeptide binding]; other site
103690017606	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
103690017607	putative N-terminal domain interface [polypeptide binding]; other site
103690017608	putative dimer interface [polypeptide binding]; other site
103690017609	putative substrate binding pocket (H-site) [chemical binding]; other site
103690017610	Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637
103690017611	Protein of unknown function DUF91; Region: DUF91; cl00709
103690017612	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
103690017613	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
103690017614	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
103690017615	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
103690017616	active site
103690017617	substrate binding site [chemical binding]; other site
103690017618	Mg2+ binding site [ion binding]; other site
103690017619	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
103690017620	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550
103690017621	Protein of unknown function (DUF1392); Region: DUF1392; pfam07154
103690017622	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
103690017623	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
103690017624	cofactor binding site; other site
103690017625	DNA binding site [nucleotide binding]
103690017626	substrate interaction site [chemical binding]; other site
103690017627	ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554
103690017628	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
103690017629	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
103690017630	MULE transposase domain; Region: MULE; pfam10551
103690017631	SusE outer membrane protein; Region: SusE; pfam14292
103690017632	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
103690017633	active site
103690017634	metal binding site [ion binding]; metal-binding site
103690017635	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
103690017636	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
103690017637	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
103690017638	Catalytic site; other site
103690017639	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
103690017640	Staphylococcal nuclease homologue; Region: SNase; pfam00565
103690017641	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
103690017642	Mechanosensitive ion channel; Region: MS_channel; pfam00924
103690017643	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
103690017644	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
103690017645	active site
103690017646	ATP binding site [chemical binding]; other site
103690017647	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542