-- dump date   	20140619_223435
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
702113000001	ParB-like nuclease domain; Region: ParB; smart00470
702113000002	Toprim domain; Region: Toprim_3; pfam13362
702113000003	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113000004	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
702113000005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000006	non-specific DNA binding site [nucleotide binding]; other site
702113000007	salt bridge; other site
702113000008	sequence-specific DNA binding site [nucleotide binding]; other site
702113000009	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
702113000010	Abi-like protein; Region: Abi_2; pfam07751
702113000011	putative addiction module antidote; Region: doc_partner; TIGR02609
702113000012	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
702113000013	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
702113000014	Uncharacterized conserved protein [Function unknown]; Region: COG5489
702113000015	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
702113000016	Replication initiator protein A; Region: RPA; pfam10134
702113000017	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
702113000018	Protein of unknown function (DUF736); Region: DUF736; pfam05284
702113000019	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
702113000020	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113000021	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113000022	catalytic residue [active]
702113000023	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
702113000024	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
702113000025	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
702113000026	The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion. These proteins aid the transfer of DNA from the plasmid into the host bacterial chromosome. They contain an ATP binding domain. VirD4 is involved in DNA transfer...; Region: TraG_VirD4; cd01126
702113000027	Walker A motif; other site
702113000028	ATP binding site [chemical binding]; other site
702113000029	Walker B motif; other site
702113000030	DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188
702113000031	Autoinducer binding domain; Region: Autoind_bind; pfam03472
702113000032	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113000033	DNA binding residues [nucleotide binding]
702113000034	Autoinducer synthetase; Region: Autoind_synth; cl17404
702113000035	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
702113000036	Transcriptional regulators [Transcription]; Region: GntR; COG1802
702113000037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113000038	DNA-binding site [nucleotide binding]; DNA binding site
702113000039	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
702113000040	active site
702113000041	NTP binding site [chemical binding]; other site
702113000042	metal binding triad [ion binding]; metal-binding site
702113000043	antibiotic binding site [chemical binding]; other site
702113000044	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
702113000045	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113000046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113000047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113000048	DNA binding residues [nucleotide binding]
702113000049	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113000050	FecR protein; Region: FecR; pfam04773
702113000051	Secretin and TonB N terminus short domain; Region: STN; smart00965
702113000052	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113000053	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113000054	N-terminal plug; other site
702113000055	ligand-binding site [chemical binding]; other site
702113000056	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
702113000057	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113000058	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
702113000059	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
702113000060	Ligand Binding Site [chemical binding]; other site
702113000061	Molecular Tunnel; other site
702113000062	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
702113000063	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
702113000064	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113000065	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
702113000066	VirB7 interaction site; other site
702113000067	conjugal transfer protein TrbF; Provisional; Region: PRK13872
702113000068	conjugal transfer protein TrbL; Provisional; Region: PRK13875
702113000069	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
702113000070	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
702113000071	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
702113000072	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
702113000073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113000074	Walker A/P-loop; other site
702113000075	ATP binding site [chemical binding]; other site
702113000076	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
702113000077	TrbC/VIRB2 family; Region: TrbC; pfam04956
702113000078	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
702113000079	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113000080	Walker A motif; other site
702113000081	ATP binding site [chemical binding]; other site
702113000082	Walker B motif; other site
702113000083	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113000084	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
702113000085	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
702113000086	Transposase; Region: HTH_Tnp_1; pfam01527
702113000087	HTH-like domain; Region: HTH_21; pfam13276
702113000088	Integrase core domain; Region: rve; pfam00665
702113000089	Integrase core domain; Region: rve_3; cl15866
702113000090	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113000091	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
702113000092	catalytic residues [active]
702113000093	catalytic nucleophile [active]
702113000094	Recombinase; Region: Recombinase; pfam07508
702113000095	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
702113000096	Integrase core domain; Region: rve_3; cl15866
702113000097	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
702113000098	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
702113000099	NADP-binding site; other site
702113000100	homotetramer interface [polypeptide binding]; other site
702113000101	substrate binding site [chemical binding]; other site
702113000102	homodimer interface [polypeptide binding]; other site
702113000103	active site
702113000104	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
702113000105	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113000106	NADP-binding site; other site
702113000107	homotetramer interface [polypeptide binding]; other site
702113000108	substrate binding site [chemical binding]; other site
702113000109	homodimer interface [polypeptide binding]; other site
702113000110	active site
702113000111	Transposase, Mutator family; Region: Transposase_mut; pfam00872
702113000112	Transposase, Mutator family; Region: Transposase_mut; pfam00872
702113000113	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113000114	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000115	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
702113000116	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000117	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113000118	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000119	Right handed beta helix region; Region: Beta_helix; pfam13229
702113000120	Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579
702113000121	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000122	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
702113000123	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113000124	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000125	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113000126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000127	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
702113000128	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
702113000129	Walker A/P-loop; other site
702113000130	ATP binding site [chemical binding]; other site
702113000131	Q-loop/lid; other site
702113000132	ABC transporter signature motif; other site
702113000133	Walker B; other site
702113000134	D-loop; other site
702113000135	H-loop/switch region; other site
702113000136	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
702113000137	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
702113000138	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
702113000139	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
702113000140	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
702113000141	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
702113000142	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113000143	ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088
702113000144	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
702113000145	active site
702113000146	substrate binding site [chemical binding]; other site
702113000147	metal binding site [ion binding]; metal-binding site
702113000148	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
702113000149	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
702113000150	Substrate binding site; other site
702113000151	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
702113000152	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
702113000153	Sulfatase; Region: Sulfatase; cl17466
702113000154	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
702113000155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113000156	Walker A motif; other site
702113000157	ATP binding site [chemical binding]; other site
702113000158	Walker B motif; other site
702113000159	arginine finger; other site
702113000160	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
702113000161	Integrase core domain; Region: rve; pfam00665
702113000162	Domain of unknown function (DUF4409); Region: DUF4409; pfam14365
702113000163	Domain of unknown function (DUF239); Region: DUF239; pfam03080
702113000164	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
702113000165	MerR family regulatory protein; Region: MerR; pfam00376
702113000166	DNA binding residues [nucleotide binding]
702113000167	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113000168	P-loop; other site
702113000169	Magnesium ion binding site [ion binding]; other site
702113000170	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113000171	Magnesium ion binding site [ion binding]; other site
702113000172	ParB-like nuclease domain; Region: ParBc; pfam02195
702113000173	Replication initiator protein A; Region: RPA; pfam10134
702113000174	HipA N-terminal domain; Region: Couple_hipA; pfam13657
702113000175	HipA-like N-terminal domain; Region: HipA_N; pfam07805
702113000176	HipA-like C-terminal domain; Region: HipA_C; pfam07804
702113000177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000178	non-specific DNA binding site [nucleotide binding]; other site
702113000179	salt bridge; other site
702113000180	sequence-specific DNA binding site [nucleotide binding]; other site
702113000181	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113000182	active site
702113000183	DNA binding site [nucleotide binding]
702113000184	Int/Topo IB signature motif; other site
702113000185	HipA-like N-terminal domain; Region: HipA_N; pfam07805
702113000186	HipA-like C-terminal domain; Region: HipA_C; pfam07804
702113000187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000188	non-specific DNA binding site [nucleotide binding]; other site
702113000189	salt bridge; other site
702113000190	sequence-specific DNA binding site [nucleotide binding]; other site
702113000191	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
702113000192	putative active site [active]
702113000193	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113000194	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
702113000195	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113000196	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113000197	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
702113000198	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
702113000199	DXD motif; other site
702113000200	PilZ domain; Region: PilZ; pfam07238
702113000201	cellulose synthase regulator protein; Provisional; Region: PRK11114
702113000202	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
702113000203	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
702113000204	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
702113000205	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
702113000206	putative molybdopterin cofactor binding site [chemical binding]; other site
702113000207	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
702113000208	putative molybdopterin cofactor binding site; other site
702113000209	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
702113000210	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
702113000211	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113000212	AsnC family; Region: AsnC_trans_reg; pfam01037
702113000213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000214	non-specific DNA binding site [nucleotide binding]; other site
702113000215	salt bridge; other site
702113000216	sequence-specific DNA binding site [nucleotide binding]; other site
702113000217	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
702113000218	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
702113000219	Integrase core domain; Region: rve; pfam00665
702113000220	transposase/IS protein; Provisional; Region: PRK09183
702113000221	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113000222	Walker A motif; other site
702113000223	ATP binding site [chemical binding]; other site
702113000224	Walker B motif; other site
702113000225	arginine finger; other site
702113000226	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
702113000227	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
702113000228	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
702113000229	putative dimer interface [polypeptide binding]; other site
702113000230	Phasin protein; Region: Phasin_2; pfam09361
702113000231	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
702113000232	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
702113000233	NAD(P) binding site [chemical binding]; other site
702113000234	homotetramer interface [polypeptide binding]; other site
702113000235	homodimer interface [polypeptide binding]; other site
702113000236	active site
702113000237	PilZ domain; Region: PilZ; pfam07238
702113000238	PilZ domain; Region: PilZ; pfam07238
702113000239	YqcI/YcgG family; Region: YqcI_YcgG; cl01349
702113000240	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
702113000241	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
702113000242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000243	sequence-specific DNA binding site [nucleotide binding]; other site
702113000244	salt bridge; other site
702113000245	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
702113000246	HipA N-terminal domain; Region: Couple_hipA; pfam13657
702113000247	HipA-like N-terminal domain; Region: HipA_N; pfam07805
702113000248	HipA-like C-terminal domain; Region: HipA_C; pfam07804
702113000249	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
702113000250	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113000251	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
702113000252	Predicted membrane protein [Function unknown]; Region: COG3503
702113000253	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113000254	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
702113000255	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113000256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
702113000257	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
702113000258	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
702113000259	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113000260	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
702113000261	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113000262	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113000263	N-terminal plug; other site
702113000264	ligand-binding site [chemical binding]; other site
702113000265	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113000266	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
702113000267	potassium uptake protein; Region: kup; TIGR00794
702113000268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
702113000269	dimer interface [polypeptide binding]; other site
702113000270	phosphorylation site [posttranslational modification]
702113000271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113000272	ATP binding site [chemical binding]; other site
702113000273	Mg2+ binding site [ion binding]; other site
702113000274	G-X-G motif; other site
702113000275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113000276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113000277	active site
702113000278	phosphorylation site [posttranslational modification]
702113000279	intermolecular recognition site; other site
702113000280	dimerization interface [polypeptide binding]; other site
702113000281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113000282	DNA binding site [nucleotide binding]
702113000283	Protein of unknown function (DUF497); Region: DUF497; cl01108
702113000284	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
702113000285	AAA domain; Region: AAA_21; pfam13304
702113000286	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
702113000287	Q-loop/lid; other site
702113000288	Walker B; other site
702113000289	D-loop; other site
702113000290	H-loop/switch region; other site
702113000291	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
702113000292	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
702113000293	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113000294	active site
702113000295	DNA binding site [nucleotide binding]
702113000296	Int/Topo IB signature motif; other site
702113000297	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113000298	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113000299	Sulfatase; Region: Sulfatase; cl17466
702113000300	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000301	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
702113000302	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
702113000303	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
702113000304	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113000305	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113000306	non-specific DNA binding site [nucleotide binding]; other site
702113000307	salt bridge; other site
702113000308	sequence-specific DNA binding site [nucleotide binding]; other site
702113000309	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
702113000310	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113000311	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113000312	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113000313	N-terminal plug; other site
702113000314	ligand-binding site [chemical binding]; other site
702113000315	Antitoxin ParD; Region: ParD; pfam09386
702113000316	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
702113000317	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
702113000318	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
702113000319	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
702113000320	active site
702113000321	catalytic residues [active]
702113000322	DNA binding site [nucleotide binding]
702113000323	Int/Topo IB signature motif; other site
702113000324	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
702113000325	substrate binding site [chemical binding]; other site
702113000326	active site
702113000327	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
702113000328	transcription termination factor Rho; Provisional; Region: rho; PRK09376
702113000329	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
702113000330	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
702113000331	RNA binding site [nucleotide binding]; other site
702113000332	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
702113000333	multimer interface [polypeptide binding]; other site
702113000334	Walker A motif; other site
702113000335	ATP binding site [chemical binding]; other site
702113000336	Walker B motif; other site
702113000337	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
702113000338	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
702113000339	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
702113000340	NADP binding site [chemical binding]; other site
702113000341	dimer interface [polypeptide binding]; other site
702113000342	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
702113000343	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
702113000344	active site
702113000345	FMN binding site [chemical binding]; other site
702113000346	substrate binding site [chemical binding]; other site
702113000347	3Fe-4S cluster binding site [ion binding]; other site
702113000348	Dienelactone hydrolase family; Region: DLH; pfam01738
702113000349	Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752
702113000350	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
702113000351	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
702113000352	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
702113000353	G1 box; other site
702113000354	GTP/Mg2+ binding site [chemical binding]; other site
702113000355	G2 box; other site
702113000356	Switch I region; other site
702113000357	G3 box; other site
702113000358	Switch II region; other site
702113000359	G5 box; other site
702113000360	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
702113000361	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
702113000362	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
702113000363	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
702113000364	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
702113000365	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
702113000366	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113000367	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113000368	P-loop; other site
702113000369	Magnesium ion binding site [ion binding]; other site
702113000370	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113000371	Magnesium ion binding site [ion binding]; other site
702113000372	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
702113000373	ParB-like nuclease domain; Region: ParBc; pfam02195
702113000374	KorB domain; Region: KorB; pfam08535
702113000375	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
702113000376	GAF domain; Region: GAF_2; pfam13185
702113000377	Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133
702113000378	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
702113000379	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
702113000380	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
702113000381	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
702113000382	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
702113000383	Ferredoxin [Energy production and conversion]; Region: COG1146
702113000384	4Fe-4S binding domain; Region: Fer4; cl02805
702113000385	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
702113000386	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
702113000387	RNA binding surface [nucleotide binding]; other site
702113000388	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
702113000389	ATP binding site [chemical binding]; other site
702113000390	putative Mg++ binding site [ion binding]; other site
702113000391	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113000392	nucleotide binding region [chemical binding]; other site
702113000393	ATP-binding site [chemical binding]; other site
702113000394	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113000395	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113000396	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
702113000397	dimer interface [polypeptide binding]; other site
702113000398	allosteric magnesium binding site [ion binding]; other site
702113000399	active site
702113000400	aspartate-rich active site metal binding site; other site
702113000401	Schiff base residues; other site
702113000402	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
702113000403	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
702113000404	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113000405	S-adenosylmethionine binding site [chemical binding]; other site
702113000406	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
702113000407	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
702113000408	trimer interface [polypeptide binding]; other site
702113000409	putative metal binding site [ion binding]; other site
702113000410	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
702113000411	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
702113000412	apolar tunnel; other site
702113000413	heme binding site [chemical binding]; other site
702113000414	dimerization interface [polypeptide binding]; other site
702113000415	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
702113000416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113000417	Walker A motif; other site
702113000418	ATP binding site [chemical binding]; other site
702113000419	Walker B motif; other site
702113000420	arginine finger; other site
702113000421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113000422	Walker A motif; other site
702113000423	ATP binding site [chemical binding]; other site
702113000424	Walker B motif; other site
702113000425	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
702113000426	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
702113000427	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
702113000428	NAD(P) binding site [chemical binding]; other site
702113000429	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113000430	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
702113000431	putative C-terminal domain interface [polypeptide binding]; other site
702113000432	putative GSH binding site (G-site) [chemical binding]; other site
702113000433	putative dimer interface [polypeptide binding]; other site
702113000434	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113000435	N-terminal domain interface [polypeptide binding]; other site
702113000436	dimer interface [polypeptide binding]; other site
702113000437	substrate binding pocket (H-site) [chemical binding]; other site
702113000438	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
702113000439	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
702113000440	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
702113000441	acyl-activating enzyme (AAE) consensus motif; other site
702113000442	putative AMP binding site [chemical binding]; other site
702113000443	putative active site [active]
702113000444	putative CoA binding site [chemical binding]; other site
702113000445	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
702113000446	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
702113000447	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113000448	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113000449	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
702113000450	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
702113000451	putative catalytic cysteine [active]
702113000452	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
702113000453	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
702113000454	active site
702113000455	(T/H)XGH motif; other site
702113000456	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
702113000457	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
702113000458	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
702113000459	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
702113000460	active site
702113000461	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
702113000462	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
702113000463	CoA-ligase; Region: Ligase_CoA; pfam00549
702113000464	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
702113000465	Ligand binding site [chemical binding]; other site
702113000466	Electron transfer flavoprotein domain; Region: ETF; pfam01012
702113000467	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
702113000468	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
702113000469	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
702113000470	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
702113000471	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
702113000472	Protein of unknown function (DUF445); Region: DUF445; pfam04286
702113000473	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
702113000474	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
702113000475	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
702113000476	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
702113000477	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113000478	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
702113000479	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
702113000480	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
702113000481	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
702113000482	Beta-lactamase; Region: Beta-lactamase; pfam00144
702113000483	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
702113000484	Cation efflux family; Region: Cation_efflux; cl00316
702113000485	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
702113000486	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
702113000487	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
702113000488	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
702113000489	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
702113000490	HSP70 interaction site [polypeptide binding]; other site
702113000491	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
702113000492	substrate binding site [polypeptide binding]; other site
702113000493	dimer interface [polypeptide binding]; other site
702113000494	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
702113000495	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
702113000496	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
702113000497	NAD binding site [chemical binding]; other site
702113000498	homotetramer interface [polypeptide binding]; other site
702113000499	homodimer interface [polypeptide binding]; other site
702113000500	substrate binding site [chemical binding]; other site
702113000501	active site
702113000502	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
702113000503	dinuclear metal binding motif [ion binding]; other site
702113000504	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
702113000505	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
702113000506	C-terminal peptidase (prc); Region: prc; TIGR00225
702113000507	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
702113000508	protein binding site [polypeptide binding]; other site
702113000509	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
702113000510	Catalytic dyad [active]
702113000511	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113000512	putative outer membrane lipoprotein; Provisional; Region: PRK10510
702113000513	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113000514	ligand binding site [chemical binding]; other site
702113000515	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
702113000516	Domain of unknown function DUF21; Region: DUF21; pfam01595
702113000517	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
702113000518	Transporter associated domain; Region: CorC_HlyC; smart01091
702113000519	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
702113000520	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
702113000521	lipoprotein signal peptidase; Provisional; Region: PRK14787
702113000522	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
702113000523	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113000524	active site
702113000525	HIGH motif; other site
702113000526	nucleotide binding site [chemical binding]; other site
702113000527	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
702113000528	active site
702113000529	KMSKS motif; other site
702113000530	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
702113000531	tRNA binding surface [nucleotide binding]; other site
702113000532	anticodon binding site; other site
702113000533	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
702113000534	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
702113000535	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
702113000536	active site
702113000537	Riboflavin kinase; Region: Flavokinase; smart00904
702113000538	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
702113000539	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
702113000540	folate binding site [chemical binding]; other site
702113000541	NADP+ binding site [chemical binding]; other site
702113000542	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
702113000543	XdhC Rossmann domain; Region: XdhC_C; pfam13478
702113000544	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113000545	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
702113000546	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
702113000547	catalytic core [active]
702113000548	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
702113000549	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113000550	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113000551	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113000552	Phytase; Region: Phytase; cl17685
702113000553	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
702113000554	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113000555	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113000556	catalytic residue [active]
702113000557	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
702113000558	active site
702113000559	tetramer interface; other site
702113000560	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
702113000561	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
702113000562	hinge; other site
702113000563	active site
702113000564	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
702113000565	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
702113000566	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
702113000567	NAD(P) binding site [chemical binding]; other site
702113000568	homotetramer interface [polypeptide binding]; other site
702113000569	homodimer interface [polypeptide binding]; other site
702113000570	active site
702113000571	MltA-interacting protein MipA; Region: MipA; cl01504
702113000572	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
702113000573	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
702113000574	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
702113000575	HIGH motif; other site
702113000576	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
702113000577	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113000578	active site
702113000579	KMSKS motif; other site
702113000580	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
702113000581	tRNA binding surface [nucleotide binding]; other site
702113000582	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
702113000583	Lipopolysaccharide-assembly; Region: LptE; pfam04390
702113000584	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
702113000585	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
702113000586	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
702113000587	Bacterial sugar transferase; Region: Bac_transf; pfam02397
702113000588	OstA-like protein; Region: OstA; pfam03968
702113000589	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
702113000590	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
702113000591	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
702113000592	catalytic site [active]
702113000593	putative active site [active]
702113000594	putative substrate binding site [chemical binding]; other site
702113000595	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
702113000596	ligand binding site [chemical binding]; other site
702113000597	active site
702113000598	UGI interface [polypeptide binding]; other site
702113000599	catalytic site [active]
702113000600	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
702113000601	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
702113000602	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
702113000603	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
702113000604	active site
702113000605	dimer interface [polypeptide binding]; other site
702113000606	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
702113000607	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
702113000608	active site
702113000609	FMN binding site [chemical binding]; other site
702113000610	substrate binding site [chemical binding]; other site
702113000611	3Fe-4S cluster binding site [ion binding]; other site
702113000612	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
702113000613	domain interface; other site
702113000614	PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063
702113000615	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
702113000616	O-Antigen ligase; Region: Wzy_C; cl04850
702113000617	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113000618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113000619	active site
702113000620	phosphorylation site [posttranslational modification]
702113000621	intermolecular recognition site; other site
702113000622	dimerization interface [polypeptide binding]; other site
702113000623	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113000624	DNA binding site [nucleotide binding]
702113000625	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
702113000626	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113000627	LrgB-like family; Region: LrgB; pfam04172
702113000628	LrgA family; Region: LrgA; pfam03788
702113000629	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
702113000630	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
702113000631	Malic enzyme, N-terminal domain; Region: malic; pfam00390
702113000632	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
702113000633	putative NAD(P) binding site [chemical binding]; other site
702113000634	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
702113000635	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
702113000636	MutS domain I; Region: MutS_I; pfam01624
702113000637	MutS domain II; Region: MutS_II; pfam05188
702113000638	MutS domain III; Region: MutS_III; pfam05192
702113000639	MutS domain V; Region: MutS_V; pfam00488
702113000640	Walker A/P-loop; other site
702113000641	ATP binding site [chemical binding]; other site
702113000642	Q-loop/lid; other site
702113000643	ABC transporter signature motif; other site
702113000644	Walker B; other site
702113000645	D-loop; other site
702113000646	H-loop/switch region; other site
702113000647	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
702113000648	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
702113000649	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113000650	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
702113000651	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
702113000652	active site
702113000653	HIGH motif; other site
702113000654	nucleotide binding site [chemical binding]; other site
702113000655	active site
702113000656	KMSKS motif; other site
702113000657	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
702113000658	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
702113000659	active site
702113000660	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
702113000661	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
702113000662	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
702113000663	substrate binding site [chemical binding]; other site
702113000664	hexamer interface [polypeptide binding]; other site
702113000665	metal binding site [ion binding]; metal-binding site
702113000666	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
702113000667	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
702113000668	active site
702113000669	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
702113000670	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
702113000671	nucleotide binding site/active site [active]
702113000672	HIT family signature motif; other site
702113000673	catalytic residue [active]
702113000674	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
702113000675	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
702113000676	active site
702113000677	metal-binding site
702113000678	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
702113000679	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
702113000680	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
702113000681	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
702113000682	metal binding site [ion binding]; metal-binding site
702113000683	dimer interface [polypeptide binding]; other site
702113000684	5-oxoprolinase; Region: PLN02666
702113000685	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
702113000686	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
702113000687	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
702113000688	Predicted acetyltransferase [General function prediction only]; Region: COG2388
702113000689	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
702113000690	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
702113000691	tetramer interface [polypeptide binding]; other site
702113000692	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113000693	catalytic residue [active]
702113000694	EamA-like transporter family; Region: EamA; pfam00892
702113000695	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
702113000696	EamA-like transporter family; Region: EamA; cl17759
702113000697	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113000698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113000699	NAD(P) binding site [chemical binding]; other site
702113000700	active site
702113000701	Peptidase family M48; Region: Peptidase_M48; cl12018
702113000702	aminopeptidase N; Provisional; Region: pepN; PRK14015
702113000703	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
702113000704	Zn binding site [ion binding]; other site
702113000705	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
702113000706	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
702113000707	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
702113000708	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
702113000709	[2Fe-2S] cluster binding site [ion binding]; other site
702113000710	cytochrome b; Provisional; Region: CYTB; MTH00191
702113000711	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
702113000712	intrachain domain interface; other site
702113000713	interchain domain interface [polypeptide binding]; other site
702113000714	heme bH binding site [chemical binding]; other site
702113000715	Qi binding site; other site
702113000716	heme bL binding site [chemical binding]; other site
702113000717	Qo binding site; other site
702113000718	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
702113000719	interchain domain interface [polypeptide binding]; other site
702113000720	intrachain domain interface; other site
702113000721	Qi binding site; other site
702113000722	Qo binding site; other site
702113000723	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
702113000724	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113000725	active site
702113000726	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
702113000727	oxidoreductase; Provisional; Region: PRK12742
702113000728	classical (c) SDRs; Region: SDR_c; cd05233
702113000729	NAD(P) binding site [chemical binding]; other site
702113000730	active site
702113000731	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113000732	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113000733	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
702113000734	putative effector binding pocket; other site
702113000735	dimerization interface [polypeptide binding]; other site
702113000736	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113000737	potential protein location (putative uncharacterized protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113000738	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113000739	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (23S ribosomal RNA)
702113000740	AIPR protein; Region: AIPR; pfam10592
702113000741	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113000742	active site
702113000743	DNA binding site [nucleotide binding]
702113000744	Int/Topo IB signature motif; other site
702113000745	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
702113000746	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
702113000747	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000748	Sulfatase; Region: Sulfatase; pfam00884
702113000749	Sulfatase; Region: Sulfatase; cl17466
702113000750	HEAT repeats; Region: HEAT_2; pfam13646
702113000751	Sulfatase; Region: Sulfatase; cl17466
702113000752	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000753	Sulfatase; Region: Sulfatase; pfam00884
702113000754	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000755	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000756	Sulfatase; Region: Sulfatase; pfam00884
702113000757	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113000758	Sulfatase; Region: Sulfatase; pfam00884
702113000759	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113000760	putative substrate translocation pore; other site
702113000761	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113000762	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113000763	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
702113000764	gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272
702113000765	Cupin domain; Region: Cupin_2; pfam07883
702113000766	Cupin domain; Region: Cupin_2; pfam07883
702113000767	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
702113000768	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113000769	maleylacetoacetate isomerase; Region: maiA; TIGR01262
702113000770	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
702113000771	C-terminal domain interface [polypeptide binding]; other site
702113000772	GSH binding site (G-site) [chemical binding]; other site
702113000773	putative dimer interface [polypeptide binding]; other site
702113000774	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
702113000775	dimer interface [polypeptide binding]; other site
702113000776	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
702113000777	N-terminal domain interface [polypeptide binding]; other site
702113000778	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
702113000779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113000780	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113000781	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113000782	ligand binding site [chemical binding]; other site
702113000783	flexible hinge region; other site
702113000784	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
702113000785	putative switch regulator; other site
702113000786	non-specific DNA interactions [nucleotide binding]; other site
702113000787	DNA binding site [nucleotide binding]
702113000788	sequence specific DNA binding site [nucleotide binding]; other site
702113000789	putative cAMP binding site [chemical binding]; other site
702113000790	potential frameshift: common BLAST hit: gi|85372950|ref|YP_457012.1| sulfotransferase
702113000791	GtrA-like protein; Region: GtrA; pfam04138
702113000792	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
702113000793	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
702113000794	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
702113000795	Low-spin heme binding site [chemical binding]; other site
702113000796	Putative water exit pathway; other site
702113000797	Binuclear center (active site) [active]
702113000798	Putative proton exit pathway; other site
702113000799	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
702113000800	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
702113000801	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
702113000802	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
702113000803	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113000804	Cytochrome c; Region: Cytochrom_C; pfam00034
702113000805	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
702113000806	4Fe-4S binding domain; Region: Fer4_5; pfam12801
702113000807	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
702113000808	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
702113000809	FixH; Region: FixH; pfam05751
702113000810	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
702113000811	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
702113000812	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
702113000813	metal-binding site [ion binding]
702113000814	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113000815	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113000816	motif II; other site
702113000817	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; cl01253
702113000818	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
702113000819	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
702113000820	FeS/SAM binding site; other site
702113000821	HemN C-terminal domain; Region: HemN_C; pfam06969
702113000822	Amidohydrolase; Region: Amidohydro_2; pfam04909
702113000823	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
702113000824	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
702113000825	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
702113000826	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
702113000827	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
702113000828	Putative phosphatase (DUF442); Region: DUF442; cl17385
702113000829	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
702113000830	Predicted transporter component [General function prediction only]; Region: COG2391
702113000831	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
702113000832	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
702113000833	putative peroxiredoxin; Provisional; Region: PRK13190
702113000834	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113000835	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113000836	dimerization interface [polypeptide binding]; other site
702113000837	putative DNA binding site [nucleotide binding]; other site
702113000838	putative Zn2+ binding site [ion binding]; other site
702113000839	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113000840	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113000841	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
702113000842	dinuclear metal binding motif [ion binding]; other site
702113000843	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
702113000844	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
702113000845	catalytic triad [active]
702113000846	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
702113000847	metal binding triad; other site
702113000848	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
702113000849	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
702113000850	metal binding triad; other site
702113000851	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
702113000852	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
702113000853	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
702113000854	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
702113000855	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
702113000856	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113000857	S-adenosylmethionine binding site [chemical binding]; other site
702113000858	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
702113000859	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
702113000860	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
702113000861	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
702113000862	active site
702113000863	dimer interface [polypeptide binding]; other site
702113000864	motif 1; other site
702113000865	motif 2; other site
702113000866	motif 3; other site
702113000867	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
702113000868	anticodon binding site; other site
702113000869	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113000870	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113000871	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113000872	binding surface
702113000873	Tetratricopeptide repeat; Region: TPR_16; pfam13432
702113000874	TPR motif; other site
702113000875	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
702113000876	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
702113000877	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
702113000878	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
702113000879	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113000880	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113000881	epoxyqueuosine reductase; Region: TIGR00276
702113000882	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
702113000883	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
702113000884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113000885	Walker A/P-loop; other site
702113000886	ATP binding site [chemical binding]; other site
702113000887	Q-loop/lid; other site
702113000888	ABC transporter signature motif; other site
702113000889	Walker B; other site
702113000890	D-loop; other site
702113000891	H-loop/switch region; other site
702113000892	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
702113000893	methionine sulfoxide reductase B; Provisional; Region: PRK00222
702113000894	SelR domain; Region: SelR; pfam01641
702113000895	PilZ domain; Region: PilZ; pfam07238
702113000896	PilZ domain; Region: PilZ; pfam07238
702113000897	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
702113000898	IHF dimer interface [polypeptide binding]; other site
702113000899	IHF - DNA interface [nucleotide binding]; other site
702113000900	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
702113000901	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113000902	putative substrate translocation pore; other site
702113000903	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
702113000904	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
702113000905	active site
702113000906	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113000907	Amidohydrolase; Region: Amidohydro_4; pfam13147
702113000908	active site
702113000909	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
702113000910	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
702113000911	TPP-binding site; other site
702113000912	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
702113000913	PYR/PP interface [polypeptide binding]; other site
702113000914	dimer interface [polypeptide binding]; other site
702113000915	TPP binding site [chemical binding]; other site
702113000916	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113000917	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
702113000918	metal binding site 2 [ion binding]; metal-binding site
702113000919	putative DNA binding helix; other site
702113000920	metal binding site 1 [ion binding]; metal-binding site
702113000921	dimer interface [polypeptide binding]; other site
702113000922	structural Zn2+ binding site [ion binding]; other site
702113000923	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
702113000924	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
702113000925	purine monophosphate binding site [chemical binding]; other site
702113000926	dimer interface [polypeptide binding]; other site
702113000927	putative catalytic residues [active]
702113000928	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
702113000929	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
702113000930	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
702113000931	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
702113000932	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
702113000933	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
702113000934	active site
702113000935	substrate binding site [chemical binding]; other site
702113000936	metal binding site [ion binding]; metal-binding site
702113000937	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
702113000938	dimer interface [polypeptide binding]; other site
702113000939	substrate binding site [chemical binding]; other site
702113000940	ATP binding site [chemical binding]; other site
702113000941	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
702113000942	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
702113000943	dimer interface [polypeptide binding]; other site
702113000944	catalytic triad [active]
702113000945	MASE1; Region: MASE1; pfam05231
702113000946	PAS fold; Region: PAS_4; pfam08448
702113000947	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113000948	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113000949	metal binding site [ion binding]; metal-binding site
702113000950	active site
702113000951	I-site; other site
702113000952	Predicted membrane protein [Function unknown]; Region: COG4270
702113000953	protease TldD; Provisional; Region: tldD; PRK10735
702113000954	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
702113000955	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
702113000956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113000957	Walker A/P-loop; other site
702113000958	ATP binding site [chemical binding]; other site
702113000959	Q-loop/lid; other site
702113000960	ABC transporter signature motif; other site
702113000961	Walker B; other site
702113000962	D-loop; other site
702113000963	H-loop/switch region; other site
702113000964	L-aspartate oxidase; Provisional; Region: PRK09077
702113000965	L-aspartate oxidase; Provisional; Region: PRK06175
702113000966	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
702113000967	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
702113000968	Class I ribonucleotide reductase; Region: RNR_I; cd01679
702113000969	active site
702113000970	dimer interface [polypeptide binding]; other site
702113000971	catalytic residues [active]
702113000972	effector binding site; other site
702113000973	R2 peptide binding site; other site
702113000974	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
702113000975	Uncharacterized protein conserved in bacteria (DUF2171); Region: DUF2171; cl01558
702113000976	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
702113000977	dimer interface [polypeptide binding]; other site
702113000978	putative radical transfer pathway; other site
702113000979	diiron center [ion binding]; other site
702113000980	tyrosyl radical; other site
702113000981	Predicted membrane protein [Function unknown]; Region: COG3671
702113000982	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
702113000983	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
702113000984	Nucleoside recognition; Region: Gate; pfam07670
702113000985	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
702113000986	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
702113000987	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
702113000988	feedback inhibition sensing region; other site
702113000989	homohexameric interface [polypeptide binding]; other site
702113000990	nucleotide binding site [chemical binding]; other site
702113000991	N-acetyl-L-glutamate binding site [chemical binding]; other site
702113000992	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
702113000993	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
702113000994	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
702113000995	homodimer interface [polypeptide binding]; other site
702113000996	NADP binding site [chemical binding]; other site
702113000997	substrate binding site [chemical binding]; other site
702113000998	MarC family integral membrane protein; Region: MarC; cl00919
702113000999	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
702113001000	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
702113001001	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
702113001002	catalytic residues [active]
702113001003	Uncharacterized conserved protein [Function unknown]; Region: COG5489
702113001004	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113001005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113001006	non-specific DNA binding site [nucleotide binding]; other site
702113001007	salt bridge; other site
702113001008	sequence-specific DNA binding site [nucleotide binding]; other site
702113001009	Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246
702113001010	Replication initiator protein A; Region: RPA; pfam10134
702113001011	Protein of unknown function (DUF2840); Region: DUF2840; pfam11000
702113001012	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
702113001013	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
702113001014	Protein of unknown function (DUF736); Region: DUF736; pfam05284
702113001015	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
702113001016	Protein of unknown function (DUF3363); Region: DUF3363; pfam11843
702113001017	conjugal transfer coupling protein TraG; Provisional; Region: PRK13876
702113001018	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113001019	Walker A motif; other site
702113001020	ATP binding site [chemical binding]; other site
702113001021	Walker B motif; other site
702113001022	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
702113001023	Transcriptional regulator; Region: Rrf2; cl17282
702113001024	Predicted transcriptional regulator [Transcription]; Region: COG1959
702113001025	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
702113001026	heme-binding site [chemical binding]; other site
702113001027	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
702113001028	Predicted integral membrane protein [Function unknown]; Region: COG5615
702113001029	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
702113001030	heme-binding site [chemical binding]; other site
702113001031	CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448
702113001032	HPP family; Region: HPP; pfam04982
702113001033	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
702113001034	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
702113001035	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
702113001036	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
702113001037	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113001038	Walker A motif; other site
702113001039	ATP binding site [chemical binding]; other site
702113001040	Walker B motif; other site
702113001041	Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838
702113001042	conjugal transfer ATPase TrbE; Provisional; Region: PRK13873
702113001043	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
702113001044	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113001045	Walker A/P-loop; other site
702113001046	ATP binding site [chemical binding]; other site
702113001047	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
702113001048	conjugal transfer protein TrbJ; Provisional; Region: PRK13874
702113001049	conjugal transfer protein TrbL; Provisional; Region: PRK13875
702113001050	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
702113001051	conjugal transfer protein TrbF; Provisional; Region: PRK13872
702113001052	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
702113001053	VirB7 interaction site; other site
702113001054	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113001055	Protein of unknown function (DUF2274); Region: DUF2274; pfam10038
702113001056	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113001057	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113001058	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
702113001059	dimerization interface [polypeptide binding]; other site
702113001060	substrate binding pocket [chemical binding]; other site
702113001061	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
702113001062	putative metal binding site [ion binding]; other site
702113001063	Uncharacterized conserved protein [Function unknown]; Region: COG1432
702113001064	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
702113001065	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
702113001066	HsdM N-terminal domain; Region: HsdM_N; pfam12161
702113001067	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
702113001068	Methyltransferase domain; Region: Methyltransf_26; pfam13659
702113001069	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
702113001070	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
702113001071	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
702113001072	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
702113001073	Uncharacterized conserved protein [Function unknown]; Region: COG1479
702113001074	Protein of unknown function DUF262; Region: DUF262; pfam03235
702113001075	Protein of unknown function DUF262; Region: DUF262; pfam03235
702113001076	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
702113001077	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
702113001078	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
702113001079	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113001080	ATP binding site [chemical binding]; other site
702113001081	putative Mg++ binding site [ion binding]; other site
702113001082	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
702113001083	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
702113001084	ligand binding site [chemical binding]; other site
702113001085	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
702113001086	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113001087	ATP binding site [chemical binding]; other site
702113001088	putative Mg++ binding site [ion binding]; other site
702113001089	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113001090	nucleotide binding region [chemical binding]; other site
702113001091	ATP-binding site [chemical binding]; other site
702113001092	AAA domain; Region: AAA_27; pfam13514
702113001093	AAA domain; Region: AAA_27; pfam13514
702113001094	potential protein location (hypothetical protein) that overlaps protein (conserved hypothetical protein)
702113001095	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
702113001096	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113001097	active site
702113001098	metal binding site [ion binding]; metal-binding site
702113001099	DNA binding site [nucleotide binding]
702113001100	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
702113001101	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
702113001102	Protein of unknown function (DUF2958); Region: DUF2958; pfam11171
702113001103	ParB-like nuclease domain; Region: ParBc; pfam02195
702113001104	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
702113001105	active site
702113001106	catalytic site [active]
702113001107	substrate binding site [chemical binding]; other site
702113001108	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
702113001109	Domain of unknown function (DUF955); Region: DUF955; pfam06114
702113001110	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113001111	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113001112	non-specific DNA binding site [nucleotide binding]; other site
702113001113	salt bridge; other site
702113001114	sequence-specific DNA binding site [nucleotide binding]; other site
702113001115	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
702113001116	active site
702113001117	NTP binding site [chemical binding]; other site
702113001118	metal binding triad [ion binding]; metal-binding site
702113001119	Methyltransferase domain; Region: Methyltransf_26; pfam13659
702113001120	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
702113001121	DEAD-like helicases superfamily; Region: DEXDc; smart00487
702113001122	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
702113001123	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113001124	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
702113001125	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113001126	active site
702113001127	DNA binding site [nucleotide binding]
702113001128	Int/Topo IB signature motif; other site
702113001129	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113001130	active site
702113001131	DNA binding site [nucleotide binding]
702113001132	Int/Topo IB signature motif; other site
702113001133	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113001134	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
702113001135	Int/Topo IB signature motif; other site
702113001136	Helicase_C-like; Region: Helicase_C_4; pfam13871
702113001137	Toprim domain; Region: Toprim_3; pfam13362
702113001138	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113001139	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113001140	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113001141	ligand binding site [chemical binding]; other site
702113001142	flexible hinge region; other site
702113001143	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
702113001144	hypothetical protein; Provisional; Region: PRK06194
702113001145	classical (c) SDRs; Region: SDR_c; cd05233
702113001146	NAD(P) binding site [chemical binding]; other site
702113001147	active site
702113001148	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
702113001149	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
702113001150	RES domain; Region: RES; smart00953
702113001151	Protein of unknown function (DUF736); Region: DUF736; pfam05284
702113001152	Hypothetical protein (DUF2513); Region: DUF2513; pfam10711
702113001153	HNH endonuclease; Region: HNH_2; pfam13391
702113001154	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
702113001155	active site
702113001156	catalytic triad [active]
702113001157	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
702113001158	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113001159	Walker A motif; other site
702113001160	ATP binding site [chemical binding]; other site
702113001161	Walker B motif; other site
702113001162	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
702113001163	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113001164	active site
702113001165	DNA binding site [nucleotide binding]
702113001166	Int/Topo IB signature motif; other site
702113001167	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
702113001168	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
702113001169	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
702113001170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
702113001171	non-specific DNA binding site [nucleotide binding]; other site
702113001172	salt bridge; other site
702113001173	sequence-specific DNA binding site [nucleotide binding]; other site
702113001174	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
702113001175	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
702113001176	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
702113001177	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
702113001178	Phage tail tube protein FII; Region: Phage_tube; cl01390
702113001179	major tail sheath protein; Provisional; Region: FI; PHA02560
702113001180	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
702113001181	Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812
702113001182	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
702113001183	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
702113001184	Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817
702113001185	Baseplate J-like protein; Region: Baseplate_J; cl01294
702113001186	SIR2-like domain; Region: SIR2_2; pfam13289
702113001187	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
702113001188	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
702113001189	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
702113001190	Phage Tail Protein X; Region: Phage_tail_X; cl02088
702113001191	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
702113001192	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
702113001193	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
702113001194	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
702113001195	terminase ATPase subunit; Provisional; Region: P; PHA02535
702113001196	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
702113001197	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
702113001198	Phage-related protein [Function unknown]; Region: COG4695; cl01923
702113001199	Phage portal protein; Region: Phage_portal; pfam04860
702113001200	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
702113001201	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
702113001202	cofactor binding site; other site
702113001203	DNA binding site [nucleotide binding]
702113001204	substrate interaction site [chemical binding]; other site
702113001205	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
702113001206	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
702113001207	additional DNA contacts [nucleotide binding]; other site
702113001208	mismatch recognition site; other site
702113001209	active site
702113001210	zinc binding site [ion binding]; other site
702113001211	DNA intercalation site [nucleotide binding]; other site
702113001212	Helix-turn-helix domain; Region: HTH_36; pfam13730
702113001213	integrase; Provisional; Region: PRK09692
702113001214	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
702113001215	active site
702113001216	Int/Topo IB signature motif; other site
702113001217	enoyl-CoA hydratase; Provisional; Region: PRK09245
702113001218	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113001219	substrate binding site [chemical binding]; other site
702113001220	oxyanion hole (OAH) forming residues; other site
702113001221	trimer interface [polypeptide binding]; other site
702113001222	exopolyphosphatase; Region: exo_poly_only; TIGR03706
702113001223	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
702113001224	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
702113001225	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
702113001226	Cytochrome c2 [Energy production and conversion]; Region: COG3474
702113001227	prephenate dehydratase; Provisional; Region: PRK11899
702113001228	Prephenate dehydratase; Region: PDT; pfam00800
702113001229	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
702113001230	putative L-Phe binding site [chemical binding]; other site
702113001231	MoxR-like ATPases [General function prediction only]; Region: COG0714
702113001232	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113001233	Walker A motif; other site
702113001234	ATP binding site [chemical binding]; other site
702113001235	Walker B motif; other site
702113001236	arginine finger; other site
702113001237	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
702113001238	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
702113001239	metal ion-dependent adhesion site (MIDAS); other site
702113001240	Integral membrane protein DUF95; Region: DUF95; pfam01944
702113001241	RDD family; Region: RDD; pfam06271
702113001242	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113001243	Coenzyme A binding pocket [chemical binding]; other site
702113001244	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
702113001245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113001246	Coenzyme A binding pocket [chemical binding]; other site
702113001247	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
702113001248	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
702113001249	Cl binding site [ion binding]; other site
702113001250	oligomer interface [polypeptide binding]; other site
702113001251	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
702113001252	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
702113001253	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
702113001254	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
702113001255	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
702113001256	catalytic motif [active]
702113001257	Catalytic residue [active]
702113001258	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113001259	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
702113001260	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
702113001261	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
702113001262	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
702113001263	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
702113001264	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
702113001265	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
702113001266	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
702113001267	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
702113001268	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
702113001269	DNA binding site [nucleotide binding]
702113001270	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
702113001271	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
702113001272	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
702113001273	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
702113001274	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
702113001275	RPB11 interaction site [polypeptide binding]; other site
702113001276	RPB12 interaction site [polypeptide binding]; other site
702113001277	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
702113001278	RPB3 interaction site [polypeptide binding]; other site
702113001279	RPB1 interaction site [polypeptide binding]; other site
702113001280	RPB11 interaction site [polypeptide binding]; other site
702113001281	RPB10 interaction site [polypeptide binding]; other site
702113001282	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113001283	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113001284	sequence-specific DNA binding site [nucleotide binding]; other site
702113001285	salt bridge; other site
702113001286	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
702113001287	23S rRNA interface [nucleotide binding]; other site
702113001288	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
702113001289	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
702113001290	L11 interface [polypeptide binding]; other site
702113001291	putative EF-Tu interaction site [polypeptide binding]; other site
702113001292	putative EF-G interaction site [polypeptide binding]; other site
702113001293	CHAD domain; Region: CHAD; pfam05235
702113001294	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
702113001295	putative active site [active]
702113001296	putative metal binding residues [ion binding]; other site
702113001297	signature motif; other site
702113001298	putative dimer interface [polypeptide binding]; other site
702113001299	putative phosphate binding site [ion binding]; other site
702113001300	Cytochrome c; Region: Cytochrom_C; cl11414
702113001301	multidrug efflux protein; Reviewed; Region: PRK01766
702113001302	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
702113001303	cation binding site [ion binding]; other site
702113001304	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
702113001305	oligomerisation interface [polypeptide binding]; other site
702113001306	mobile loop; other site
702113001307	roof hairpin; other site
702113001308	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
702113001309	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
702113001310	ring oligomerisation interface [polypeptide binding]; other site
702113001311	ATP/Mg binding site [chemical binding]; other site
702113001312	stacking interactions; other site
702113001313	hinge regions; other site
702113001314	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
702113001315	DNA polymerase I; Provisional; Region: PRK05755
702113001316	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
702113001317	active site
702113001318	metal binding site 1 [ion binding]; metal-binding site
702113001319	putative 5' ssDNA interaction site; other site
702113001320	metal binding site 3; metal-binding site
702113001321	metal binding site 2 [ion binding]; metal-binding site
702113001322	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
702113001323	putative DNA binding site [nucleotide binding]; other site
702113001324	putative metal binding site [ion binding]; other site
702113001325	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
702113001326	active site
702113001327	catalytic site [active]
702113001328	substrate binding site [chemical binding]; other site
702113001329	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
702113001330	active site
702113001331	DNA binding site [nucleotide binding]
702113001332	catalytic site [active]
702113001333	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113001334	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
702113001335	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
702113001336	Cell division protein 48 (CDC48) domain 2; Region: CDC48_2; smart01072
702113001337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113001338	Walker A motif; other site
702113001339	ATP binding site [chemical binding]; other site
702113001340	Walker B motif; other site
702113001341	arginine finger; other site
702113001342	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113001343	Walker A motif; other site
702113001344	ATP binding site [chemical binding]; other site
702113001345	Walker B motif; other site
702113001346	arginine finger; other site
702113001347	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
702113001348	Ligand Binding Site [chemical binding]; other site
702113001349	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113001350	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113001351	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113001352	dimerization interface [polypeptide binding]; other site
702113001353	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
702113001354	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
702113001355	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
702113001356	catalytic residues [active]
702113001357	dimer interface [polypeptide binding]; other site
702113001358	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
702113001359	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113001360	putative C-terminal domain interface [polypeptide binding]; other site
702113001361	putative GSH binding site (G-site) [chemical binding]; other site
702113001362	putative dimer interface [polypeptide binding]; other site
702113001363	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
702113001364	putative N-terminal domain interface [polypeptide binding]; other site
702113001365	putative dimer interface [polypeptide binding]; other site
702113001366	putative substrate binding pocket (H-site) [chemical binding]; other site
702113001367	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
702113001368	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
702113001369	active site residue [active]
702113001370	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
702113001371	active site residue [active]
702113001372	S-adenosylmethionine synthetase; Validated; Region: PRK05250
702113001373	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
702113001374	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
702113001375	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
702113001376	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
702113001377	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
702113001378	putative active site [active]
702113001379	catalytic triad [active]
702113001380	putative dimer interface [polypeptide binding]; other site
702113001381	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
702113001382	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
702113001383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113001384	S-adenosylmethionine binding site [chemical binding]; other site
702113001385	peptide chain release factor 1; Validated; Region: prfA; PRK00591
702113001386	This domain is found in peptide chain release factors; Region: PCRF; smart00937
702113001387	RF-1 domain; Region: RF-1; pfam00472
702113001388	histidyl-tRNA synthetase; Region: hisS; TIGR00442
702113001389	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
702113001390	dimer interface [polypeptide binding]; other site
702113001391	motif 1; other site
702113001392	active site
702113001393	motif 2; other site
702113001394	motif 3; other site
702113001395	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
702113001396	anticodon binding site; other site
702113001397	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
702113001398	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
702113001399	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
702113001400	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
702113001401	dimer interface [polypeptide binding]; other site
702113001402	substrate binding site [chemical binding]; other site
702113001403	metal binding sites [ion binding]; metal-binding site
702113001404	Protein of unknown function (DUF1326); Region: DUF1326; cl02375
702113001405	Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486
702113001406	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
702113001407	succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241
702113001408	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
702113001409	tetramerization interface [polypeptide binding]; other site
702113001410	NAD(P) binding site [chemical binding]; other site
702113001411	catalytic residues [active]
702113001412	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
702113001413	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
702113001414	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
702113001415	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
702113001416	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113001417	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113001418	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
702113001419	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
702113001420	carboxyltransferase (CT) interaction site; other site
702113001421	biotinylation site [posttranslational modification]; other site
702113001422	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
702113001423	putative active site [active]
702113001424	putative catalytic site [active]
702113001425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113001426	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
702113001427	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
702113001428	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
702113001429	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113001430	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113001431	[2Fe-2S] cluster binding site [ion binding]; other site
702113001432	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
702113001433	putative alpha subunit interface [polypeptide binding]; other site
702113001434	putative active site [active]
702113001435	putative substrate binding site [chemical binding]; other site
702113001436	Fe binding site [ion binding]; other site
702113001437	Uncharacterized conserved protein [Function unknown]; Region: COG1359
702113001438	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113001439	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
702113001440	NAD(P) binding site [chemical binding]; other site
702113001441	substrate binding site [chemical binding]; other site
702113001442	dimer interface [polypeptide binding]; other site
702113001443	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113001444	fumarate hydratase; Reviewed; Region: fumC; PRK00485
702113001445	Class II fumarases; Region: Fumarase_classII; cd01362
702113001446	active site
702113001447	tetramer interface [polypeptide binding]; other site
702113001448	Pirin-related protein [General function prediction only]; Region: COG1741
702113001449	Pirin; Region: Pirin; pfam02678
702113001450	KduI/IolB family; Region: KduI; cl01508
702113001451	Pirin-related protein [General function prediction only]; Region: COG1741
702113001452	Pirin; Region: Pirin; pfam02678
702113001453	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
702113001454	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
702113001455	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113001456	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
702113001457	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
702113001458	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
702113001459	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113001460	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001461	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001462	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
702113001463	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
702113001464	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
702113001465	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
702113001466	Moco binding site; other site
702113001467	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
702113001468	metal coordination site [ion binding]; other site
702113001469	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
702113001470	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
702113001471	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
702113001472	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
702113001473	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
702113001474	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
702113001475	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
702113001476	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
702113001477	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
702113001478	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
702113001479	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
702113001480	active site
702113001481	homodimer interface [polypeptide binding]; other site
702113001482	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
702113001483	trimer interface [polypeptide binding]; other site
702113001484	active site
702113001485	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113001486	Coenzyme A binding pocket [chemical binding]; other site
702113001487	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
702113001488	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
702113001489	inhibitor-cofactor binding pocket; inhibition site
702113001490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113001491	catalytic residue [active]
702113001492	Ectoine synthase; Region: Ectoine_synth; pfam06339
702113001493	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
702113001494	aspartate kinase; Validated; Region: PRK09181
702113001495	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
702113001496	nucleotide binding site [chemical binding]; other site
702113001497	substrate binding site [chemical binding]; other site
702113001498	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
702113001499	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
702113001500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113001501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113001502	ATP binding site [chemical binding]; other site
702113001503	Mg2+ binding site [ion binding]; other site
702113001504	G-X-G motif; other site
702113001505	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
702113001506	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
702113001507	catalytic residues [active]
702113001508	argininosuccinate lyase; Provisional; Region: PRK00855
702113001509	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
702113001510	active sites [active]
702113001511	tetramer interface [polypeptide binding]; other site
702113001512	diaminopimelate decarboxylase; Region: lysA; TIGR01048
702113001513	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
702113001514	active site
702113001515	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113001516	substrate binding site [chemical binding]; other site
702113001517	catalytic residues [active]
702113001518	dimer interface [polypeptide binding]; other site
702113001519	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
702113001520	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
702113001521	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
702113001522	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
702113001523	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
702113001524	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
702113001525	Catalytic site [active]
702113001526	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
702113001527	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
702113001528	active site
702113001529	hydrophilic channel; other site
702113001530	dimerization interface [polypeptide binding]; other site
702113001531	catalytic residues [active]
702113001532	active site lid [active]
702113001533	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113001534	active site
702113001535	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
702113001536	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00154
702113001537	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
702113001538	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
702113001539	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
702113001540	Subunit I/III interface [polypeptide binding]; other site
702113001541	D-pathway; other site
702113001542	Subunit I/VIIc interface [polypeptide binding]; other site
702113001543	Subunit I/IV interface [polypeptide binding]; other site
702113001544	Subunit I/II interface [polypeptide binding]; other site
702113001545	Low-spin heme (heme a) binding site [chemical binding]; other site
702113001546	Subunit I/VIIa interface [polypeptide binding]; other site
702113001547	Subunit I/VIa interface [polypeptide binding]; other site
702113001548	Dimer interface; other site
702113001549	Putative water exit pathway; other site
702113001550	Binuclear center (heme a3/CuB) [ion binding]; other site
702113001551	K-pathway; other site
702113001552	Subunit I/Vb interface [polypeptide binding]; other site
702113001553	Putative proton exit pathway; other site
702113001554	Subunit I/VIb interface; other site
702113001555	Subunit I/VIc interface [polypeptide binding]; other site
702113001556	Electron transfer pathway; other site
702113001557	Subunit I/VIIIb interface [polypeptide binding]; other site
702113001558	Subunit I/VIIb interface [polypeptide binding]; other site
702113001559	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
702113001560	UbiA prenyltransferase family; Region: UbiA; pfam01040
702113001561	Cytochrome c oxidase assembly protein CtaG/Cox11; Region: CtaG_Cox11; pfam04442
702113001562	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
702113001563	Subunit III/VIIa interface [polypeptide binding]; other site
702113001564	Phospholipid binding site [chemical binding]; other site
702113001565	Subunit I/III interface [polypeptide binding]; other site
702113001566	Subunit III/VIb interface [polypeptide binding]; other site
702113001567	Subunit III/VIa interface; other site
702113001568	Subunit III/Vb interface [polypeptide binding]; other site
702113001569	Protein of unknown function (DUF983); Region: DUF983; cl02211
702113001570	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
702113001571	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
702113001572	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
702113001573	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113001574	catalytic residue [active]
702113001575	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
702113001576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113001577	S-adenosylmethionine binding site [chemical binding]; other site
702113001578	Dihydroneopterin aldolase; Region: FolB; smart00905
702113001579	active site
702113001580	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
702113001581	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113001582	FeS/SAM binding site; other site
702113001583	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
702113001584	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
702113001585	MoaE homodimer interface [polypeptide binding]; other site
702113001586	MoaD interaction [polypeptide binding]; other site
702113001587	active site residues [active]
702113001588	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
702113001589	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
702113001590	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
702113001591	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113001592	Coenzyme A binding pocket [chemical binding]; other site
702113001593	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
702113001594	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113001595	Coenzyme A binding pocket [chemical binding]; other site
702113001596	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
702113001597	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
702113001598	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113001599	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113001600	LysR substrate binding domain; Region: LysR_substrate; pfam03466
702113001601	dimerization interface [polypeptide binding]; other site
702113001602	Pirin-related protein [General function prediction only]; Region: COG1741
702113001603	Pirin; Region: Pirin; pfam02678
702113001604	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
702113001605	putative FMN binding site [chemical binding]; other site
702113001606	HPP family; Region: HPP; pfam04982
702113001607	dihydroorotase; Validated; Region: PRK09060
702113001608	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113001609	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
702113001610	active site
702113001611	Predicted permeases [General function prediction only]; Region: RarD; COG2962
702113001612	EamA-like transporter family; Region: EamA; cl17759
702113001613	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
702113001614	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
702113001615	NAD(P) binding site [chemical binding]; other site
702113001616	catalytic residues [active]
702113001617	hypothetical protein; Validated; Region: PRK00029
702113001618	Uncharacterized conserved protein [Function unknown]; Region: COG0397
702113001619	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113001620	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
702113001621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
702113001622	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
702113001623	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
702113001624	Trp docking motif [polypeptide binding]; other site
702113001625	active site
702113001626	PQQ-like domain; Region: PQQ_2; pfam13360
702113001627	PQQ-like domain; Region: PQQ_2; pfam13360
702113001628	Phospholipid methyltransferase; Region: PEMT; cl17370
702113001629	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
702113001630	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
702113001631	RNA methyltransferase, RsmE family; Region: TIGR00046
702113001632	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
702113001633	UbiA prenyltransferase family; Region: UbiA; pfam01040
702113001634	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
702113001635	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113001636	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113001637	active site
702113001638	metal binding site [ion binding]; metal-binding site
702113001639	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
702113001640	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
702113001641	DNA binding residues [nucleotide binding]
702113001642	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
702113001643	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
702113001644	Walker A/P-loop; other site
702113001645	ATP binding site [chemical binding]; other site
702113001646	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
702113001647	ABC transporter signature motif; other site
702113001648	Walker B; other site
702113001649	D-loop; other site
702113001650	H-loop/switch region; other site
702113001651	Thioredoxin; Region: Thioredoxin_4; cl17273
702113001652	Thioredoxin; Region: Thioredoxin_4; pfam13462
702113001653	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
702113001654	Protein of unknown function (DUF721); Region: DUF721; pfam05258
702113001655	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
702113001656	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
702113001657	minor groove reading motif; other site
702113001658	helix-hairpin-helix signature motif; other site
702113001659	substrate binding pocket [chemical binding]; other site
702113001660	active site
702113001661	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
702113001662	DNA binding and oxoG recognition site [nucleotide binding]
702113001663	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
702113001664	Beta-lactamase; Region: Beta-lactamase; pfam00144
702113001665	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
702113001666	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
702113001667	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
702113001668	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
702113001669	putative NADH binding site [chemical binding]; other site
702113001670	putative active site [active]
702113001671	nudix motif; other site
702113001672	putative metal binding site [ion binding]; other site
702113001673	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
702113001674	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
702113001675	MgtE intracellular N domain; Region: MgtE_N; smart00924
702113001676	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
702113001677	Divalent cation transporter; Region: MgtE; cl00786
702113001678	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
702113001679	active site
702113001680	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
702113001681	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113001682	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113001683	dimerization interface [polypeptide binding]; other site
702113001684	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
702113001685	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
702113001686	Transporter associated domain; Region: CorC_HlyC; smart01091
702113001687	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
702113001688	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
702113001689	PhoH-like protein; Region: PhoH; pfam02562
702113001690	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
702113001691	TAP-like protein; Region: Abhydrolase_4; pfam08386
702113001692	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
702113001693	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
702113001694	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113001695	FeS/SAM binding site; other site
702113001696	TRAM domain; Region: TRAM; cl01282
702113001697	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
702113001698	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
702113001699	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
702113001700	catalytic Zn binding site [ion binding]; other site
702113001701	NAD binding site [chemical binding]; other site
702113001702	structural Zn binding site [ion binding]; other site
702113001703	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
702113001704	classical (c) SDRs; Region: SDR_c; cd05233
702113001705	NAD(P) binding site [chemical binding]; other site
702113001706	active site
702113001707	Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156
702113001708	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
702113001709	putative ligand binding site [chemical binding]; other site
702113001710	NAD binding site [chemical binding]; other site
702113001711	catalytic site [active]
702113001712	gluconate 5-dehydrogenase; Provisional; Region: PRK07523
702113001713	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
702113001714	NADP binding site [chemical binding]; other site
702113001715	homodimer interface [polypeptide binding]; other site
702113001716	active site
702113001717	L-idonate 5-dehydrogenase; Provisional; Region: PRK09880
702113001718	L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232
702113001719	putative NAD(P) binding site [chemical binding]; other site
702113001720	catalytic Zn binding site [ion binding]; other site
702113001721	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113001722	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113001723	DNA binding site [nucleotide binding]
702113001724	domain linker motif; other site
702113001725	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
702113001726	putative dimerization interface [polypeptide binding]; other site
702113001727	putative ligand binding site [chemical binding]; other site
702113001728	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
702113001729	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
702113001730	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
702113001731	ATP-binding site [chemical binding]; other site
702113001732	Gluconate-6-phosphate binding site [chemical binding]; other site
702113001733	Shikimate kinase; Region: SKI; pfam01202
702113001734	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113001735	putative substrate translocation pore; other site
702113001736	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113001737	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
702113001738	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
702113001739	tetramer interface [polypeptide binding]; other site
702113001740	active site
702113001741	Mg2+/Mn2+ binding site [ion binding]; other site
702113001742	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113001743	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001744	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001745	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
702113001746	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
702113001747	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
702113001748	active site
702113001749	HIGH motif; other site
702113001750	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113001751	KMSK motif region; other site
702113001752	tRNA binding surface [nucleotide binding]; other site
702113001753	DALR anticodon binding domain; Region: DALR_1; smart00836
702113001754	anticodon binding site; other site
702113001755	Sporulation related domain; Region: SPOR; pfam05036
702113001756	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
702113001757	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113001758	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
702113001759	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
702113001760	twin arginine translocase protein A; Provisional; Region: tatA; PRK00720
702113001761	sec-independent translocase; Provisional; Region: tatB; PRK00404
702113001762	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
702113001763	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
702113001764	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
702113001765	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
702113001766	active site
702113001767	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
702113001768	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
702113001769	threonine dehydratase; Provisional; Region: PRK07334
702113001770	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
702113001771	tetramer interface [polypeptide binding]; other site
702113001772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113001773	catalytic residue [active]
702113001774	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
702113001775	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113001776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113001777	NAD(P) binding site [chemical binding]; other site
702113001778	active site
702113001779	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
702113001780	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
702113001781	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
702113001782	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
702113001783	catalytic residue [active]
702113001784	Fasciclin domain; Region: Fasciclin; cl02663
702113001785	glutamine synthetase; Provisional; Region: glnA; PRK09469
702113001786	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
702113001787	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
702113001788	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
702113001789	Nitrogen regulatory protein P-II; Region: P-II; smart00938
702113001790	N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863
702113001791	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113001792	Bacterial SH3 domain; Region: SH3_3; cl17532
702113001793	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
702113001794	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
702113001795	interface (dimer of trimers) [polypeptide binding]; other site
702113001796	Substrate-binding/catalytic site; other site
702113001797	Zn-binding sites [ion binding]; other site
702113001798	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
702113001799	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
702113001800	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
702113001801	active site
702113001802	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
702113001803	adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964
702113001804	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
702113001805	inhibitor-cofactor binding pocket; inhibition site
702113001806	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113001807	catalytic residue [active]
702113001808	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
702113001809	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
702113001810	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113001811	catalytic residue [active]
702113001812	Domain of unknown function DUF87; Region: DUF87; pfam01935
702113001813	HerA helicase [Replication, recombination, and repair]; Region: COG0433
702113001814	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
702113001815	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113001816	NAD(P) binding site [chemical binding]; other site
702113001817	catalytic residues [active]
702113001818	Protein of unknown function (DUF779); Region: DUF779; pfam05610
702113001819	Uncharacterized conserved protein [Function unknown]; Region: COG3287
702113001820	FIST N domain; Region: FIST; pfam08495
702113001821	FIST C domain; Region: FIST_C; pfam10442
702113001822	PAS fold; Region: PAS_7; pfam12860
702113001823	PAS fold; Region: PAS_7; pfam12860
702113001824	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113001825	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113001826	dimer interface [polypeptide binding]; other site
702113001827	phosphorylation site [posttranslational modification]
702113001828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113001829	ATP binding site [chemical binding]; other site
702113001830	Mg2+ binding site [ion binding]; other site
702113001831	G-X-G motif; other site
702113001832	Response regulator receiver domain; Region: Response_reg; pfam00072
702113001833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113001834	active site
702113001835	phosphorylation site [posttranslational modification]
702113001836	intermolecular recognition site; other site
702113001837	dimerization interface [polypeptide binding]; other site
702113001838	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113001839	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113001840	active site
702113001841	phosphorylation site [posttranslational modification]
702113001842	intermolecular recognition site; other site
702113001843	dimerization interface [polypeptide binding]; other site
702113001844	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113001845	DNA binding residues [nucleotide binding]
702113001846	dimerization interface [polypeptide binding]; other site
702113001847	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
702113001848	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
702113001849	dimer interface [polypeptide binding]; other site
702113001850	Trp docking motif [polypeptide binding]; other site
702113001851	active site
702113001852	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
702113001853	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
702113001854	substrate binding pocket [chemical binding]; other site
702113001855	membrane-bound complex binding site; other site
702113001856	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113001857	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
702113001858	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
702113001859	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
702113001860	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
702113001861	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
702113001862	Gram-negative porin; Region: Porin_4; pfam13609
702113001863	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
702113001864	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113001865	N-terminal plug; other site
702113001866	ligand-binding site [chemical binding]; other site
702113001867	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113001868	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001869	potential protein location (hypothetical protein) that overlaps protein (TonB-dependent receptor)
702113001870	Cytochrome c; Region: Cytochrom_C; cl11414
702113001871	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
702113001872	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113001873	active site
702113001874	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
702113001875	Protein of unknown function (DUF3426); Region: DUF3426; pfam11906
702113001876	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
702113001877	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113001878	Walker A/P-loop; other site
702113001879	ATP binding site [chemical binding]; other site
702113001880	Q-loop/lid; other site
702113001881	ABC transporter signature motif; other site
702113001882	Walker B; other site
702113001883	D-loop; other site
702113001884	H-loop/switch region; other site
702113001885	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
702113001886	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
702113001887	putative active site [active]
702113001888	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
702113001889	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
702113001890	putative acyl-acceptor binding pocket; other site
702113001891	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
702113001892	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
702113001893	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
702113001894	prephenate dehydrogenase; Validated; Region: PRK08507
702113001895	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
702113001896	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113001897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113001898	homodimer interface [polypeptide binding]; other site
702113001899	catalytic residue [active]
702113001900	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
702113001901	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
702113001902	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113001903	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113001904	S-adenosylmethionine binding site [chemical binding]; other site
702113001905	quinolinate synthetase; Provisional; Region: PRK09375
702113001906	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113001907	Protein of unknown function (DUF1465); Region: DUF1465; pfam07323
702113001908	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
702113001909	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
702113001910	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
702113001911	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
702113001912	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
702113001913	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113001914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113001915	non-specific DNA binding site [nucleotide binding]; other site
702113001916	salt bridge; other site
702113001917	sequence-specific DNA binding site [nucleotide binding]; other site
702113001918	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
702113001919	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
702113001920	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
702113001921	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
702113001922	Ligand Binding Site [chemical binding]; other site
702113001923	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113001924	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113001925	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113001926	WHG domain; Region: WHG; pfam13305
702113001927	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113001928	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113001929	N-terminal plug; other site
702113001930	ligand-binding site [chemical binding]; other site
702113001931	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113001932	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113001933	putative substrate translocation pore; other site
702113001934	glutamate dehydrogenase; Provisional; Region: PRK09414
702113001935	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
702113001936	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
702113001937	NAD(P) binding site [chemical binding]; other site
702113001938	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113001939	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113001940	DNA binding residues [nucleotide binding]
702113001941	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
702113001942	recombination factor protein RarA; Reviewed; Region: PRK13342
702113001943	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113001944	Walker A motif; other site
702113001945	ATP binding site [chemical binding]; other site
702113001946	Walker B motif; other site
702113001947	arginine finger; other site
702113001948	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
702113001949	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113001950	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
702113001951	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
702113001952	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
702113001953	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
702113001954	G1 box; other site
702113001955	putative GEF interaction site [polypeptide binding]; other site
702113001956	GTP/Mg2+ binding site [chemical binding]; other site
702113001957	Switch I region; other site
702113001958	G2 box; other site
702113001959	G3 box; other site
702113001960	Switch II region; other site
702113001961	G4 box; other site
702113001962	G5 box; other site
702113001963	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
702113001964	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
702113001965	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113001966	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001967	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113001968	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113001969	Protein of unknown function (DUF805); Region: DUF805; pfam05656
702113001970	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
702113001971	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
702113001972	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
702113001973	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
702113001974	Walker A/P-loop; other site
702113001975	ATP binding site [chemical binding]; other site
702113001976	Q-loop/lid; other site
702113001977	ABC transporter signature motif; other site
702113001978	Walker B; other site
702113001979	D-loop; other site
702113001980	H-loop/switch region; other site
702113001981	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
702113001982	active site
702113001983	catalytic triad [active]
702113001984	oxyanion hole [active]
702113001985	switch loop; other site
702113001986	recombination protein F; Reviewed; Region: recF; PRK00064
702113001987	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113001988	Walker A/P-loop; other site
702113001989	ATP binding site [chemical binding]; other site
702113001990	Q-loop/lid; other site
702113001991	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113001992	ABC transporter signature motif; other site
702113001993	Walker B; other site
702113001994	D-loop; other site
702113001995	H-loop/switch region; other site
702113001996	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
702113001997	TPR repeat; Region: TPR_11; pfam13414
702113001998	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113001999	TPR motif; other site
702113002000	binding surface
702113002001	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
702113002002	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
702113002003	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113002004	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113002005	ligand binding site [chemical binding]; other site
702113002006	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113002007	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113002008	ligand binding site [chemical binding]; other site
702113002009	flexible hinge region; other site
702113002010	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
702113002011	4Fe-4S binding domain; Region: Fer4; pfam00037
702113002012	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
702113002013	Prokaryotic cytochrome b561; Region: Ni_hydr_CYTB; pfam01292
702113002014	FHA domain; Region: FHA; pfam00498
702113002015	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
702113002016	heme-binding residues [chemical binding]; other site
702113002017	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
702113002018	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113002019	active site
702113002020	metal binding site [ion binding]; metal-binding site
702113002021	hexamer interface [polypeptide binding]; other site
702113002022	LVIVD repeat; Region: LVIVD; pfam08309
702113002023	Domain of unknown function (DUF336); Region: DUF336; cl01249
702113002024	Domain of unknown function (DUF336); Region: DUF336; cl01249
702113002025	haemagglutination activity domain; Region: Haemagg_act; cl05436
702113002026	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
702113002027	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
702113002028	Surface antigen; Region: Bac_surface_Ag; pfam01103
702113002029	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
702113002030	CHASE2 domain; Region: CHASE2; pfam05226
702113002031	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
702113002032	cyclase homology domain; Region: CHD; cd07302
702113002033	nucleotidyl binding site; other site
702113002034	metal binding site [ion binding]; metal-binding site
702113002035	dimer interface [polypeptide binding]; other site
702113002036	Tetratricopeptide repeat; Region: TPR_12; pfam13424
702113002037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
702113002038	binding surface
702113002039	TPR motif; other site
702113002040	CHAT domain; Region: CHAT; pfam12770
702113002041	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
702113002042	heme-binding site [chemical binding]; other site
702113002043	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
702113002044	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
702113002045	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
702113002046	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113002047	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113002048	Amidohydrolase; Region: Amidohydro_4; pfam13147
702113002049	active site
702113002050	Putative FMN-binding domain; Region: FMN_bind_2; cl17803
702113002051	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
702113002052	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113002053	DNA-binding site [nucleotide binding]; DNA binding site
702113002054	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113002055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113002056	homodimer interface [polypeptide binding]; other site
702113002057	catalytic residue [active]
702113002058	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113002059	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113002060	N-terminal plug; other site
702113002061	ligand-binding site [chemical binding]; other site
702113002062	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
702113002063	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
702113002064	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
702113002065	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113002066	HI0933-like protein; Region: HI0933_like; pfam03486
702113002067	methionine sulfoxide reductase A; Provisional; Region: PRK13014
702113002068	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113002069	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113002070	DNA binding site [nucleotide binding]
702113002071	domain linker motif; other site
702113002072	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
702113002073	putative dimerization interface [polypeptide binding]; other site
702113002074	putative ligand binding site [chemical binding]; other site
702113002075	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113002076	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113002077	putative substrate translocation pore; other site
702113002078	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
702113002079	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
702113002080	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113002081	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113002082	putative DNA binding site [nucleotide binding]; other site
702113002083	putative Zn2+ binding site [ion binding]; other site
702113002084	AsnC family; Region: AsnC_trans_reg; pfam01037
702113002085	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
702113002086	cofactor binding site; other site
702113002087	metal binding site [ion binding]; metal-binding site
702113002088	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
702113002089	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
702113002090	dimer interface [polypeptide binding]; other site
702113002091	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
702113002092	active site
702113002093	Fe binding site [ion binding]; other site
702113002094	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
702113002095	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113002096	Zn binding site [ion binding]; other site
702113002097	maleylacetoacetate isomerase; Region: maiA; TIGR01262
702113002098	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113002099	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
702113002100	N-terminal domain interface [polypeptide binding]; other site
702113002101	dimer interface [polypeptide binding]; other site
702113002102	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
702113002103	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113002104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113002105	metal binding site [ion binding]; metal-binding site
702113002106	active site
702113002107	I-site; other site
702113002108	succinylarginine dihydrolase; Provisional; Region: PRK13281
702113002109	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
702113002110	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
702113002111	hypothetical protein; Provisional; Region: PRK07338
702113002112	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
702113002113	metal binding site [ion binding]; metal-binding site
702113002114	dimer interface [polypeptide binding]; other site
702113002115	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
702113002116	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
702113002117	NAD(P) binding site [chemical binding]; other site
702113002118	catalytic residues [active]
702113002119	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
702113002120	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
702113002121	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
702113002122	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
702113002123	active site
702113002124	intersubunit interface [polypeptide binding]; other site
702113002125	catalytic residue [active]
702113002126	Glucokinase; Region: Glucokinase; pfam02685
702113002127	glucokinase, proteobacterial type; Region: glk; TIGR00749
702113002128	6-phosphogluconate dehydratase; Region: edd; TIGR01196
702113002129	phosphogluconate dehydratase; Validated; Region: PRK09054
702113002130	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
702113002131	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
702113002132	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
702113002133	PAS domain; Region: PAS_8; pfam13188
702113002134	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
702113002135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113002136	dimer interface [polypeptide binding]; other site
702113002137	phosphorylation site [posttranslational modification]
702113002138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113002139	ATP binding site [chemical binding]; other site
702113002140	Mg2+ binding site [ion binding]; other site
702113002141	G-X-G motif; other site
702113002142	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
702113002143	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
702113002144	Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746
702113002145	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
702113002146	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
702113002147	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
702113002148	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
702113002149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113002150	dimer interface [polypeptide binding]; other site
702113002151	conserved gate region; other site
702113002152	putative PBP binding loops; other site
702113002153	ABC-ATPase subunit interface; other site
702113002154	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
702113002155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113002156	dimer interface [polypeptide binding]; other site
702113002157	conserved gate region; other site
702113002158	putative PBP binding loops; other site
702113002159	ABC-ATPase subunit interface; other site
702113002160	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
702113002161	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
702113002162	Walker A/P-loop; other site
702113002163	ATP binding site [chemical binding]; other site
702113002164	Q-loop/lid; other site
702113002165	ABC transporter signature motif; other site
702113002166	Walker B; other site
702113002167	D-loop; other site
702113002168	H-loop/switch region; other site
702113002169	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
702113002170	PhoU domain; Region: PhoU; pfam01895
702113002171	PhoU domain; Region: PhoU; pfam01895
702113002172	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
702113002173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113002174	active site
702113002175	phosphorylation site [posttranslational modification]
702113002176	intermolecular recognition site; other site
702113002177	dimerization interface [polypeptide binding]; other site
702113002178	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113002179	DNA binding site [nucleotide binding]
702113002180	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113002181	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
702113002182	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113002183	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
702113002184	putative active site [active]
702113002185	putative metal binding site [ion binding]; other site
702113002186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113002187	active site
702113002188	phosphorylation site [posttranslational modification]
702113002189	intermolecular recognition site; other site
702113002190	dimerization interface [polypeptide binding]; other site
702113002191	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113002192	DNA binding site [nucleotide binding]
702113002193	Predicted membrane protein [Function unknown]; Region: COG2119
702113002194	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
702113002195	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
702113002196	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113002197	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113002198	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113002199	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
702113002200	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
702113002201	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
702113002202	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
702113002203	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
702113002204	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
702113002205	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
702113002206	VirB7 interaction site; other site
702113002207	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113002208	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
702113002209	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
702113002210	Walker A motif; other site
702113002211	hexamer interface [polypeptide binding]; other site
702113002212	ATP binding site [chemical binding]; other site
702113002213	Walker B motif; other site
702113002214	exopolyphosphatase; Region: exo_poly_only; TIGR03706
702113002215	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
702113002216	polyphosphate kinase; Provisional; Region: PRK05443
702113002217	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
702113002218	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
702113002219	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
702113002220	putative domain interface [polypeptide binding]; other site
702113002221	putative active site [active]
702113002222	catalytic site [active]
702113002223	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
702113002224	putative domain interface [polypeptide binding]; other site
702113002225	putative active site [active]
702113002226	catalytic site [active]
702113002227	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
702113002228	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
702113002229	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
702113002230	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
702113002231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
702113002232	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
702113002233	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
702113002234	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
702113002235	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
702113002236	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
702113002237	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
702113002238	CcmB protein; Region: CcmB; cl17444
702113002239	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
702113002240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113002241	Walker A/P-loop; other site
702113002242	ATP binding site [chemical binding]; other site
702113002243	ABC transporter signature motif; other site
702113002244	Walker B; other site
702113002245	D-loop; other site
702113002246	H-loop/switch region; other site
702113002247	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
702113002248	aromatic arch; other site
702113002249	DCoH dimer interaction site [polypeptide binding]; other site
702113002250	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
702113002251	DCoH tetramer interaction site [polypeptide binding]; other site
702113002252	substrate binding site [chemical binding]; other site
702113002253	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
702113002254	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
702113002255	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
702113002256	minor groove reading motif; other site
702113002257	helix-hairpin-helix signature motif; other site
702113002258	active site
702113002259	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
702113002260	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
702113002261	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
702113002262	dimer interface [polypeptide binding]; other site
702113002263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113002264	catalytic residue [active]
702113002265	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
702113002266	cell division protein MraZ; Reviewed; Region: PRK00326
702113002267	MraW methylase family; Region: Methyltransf_5; cl17771
702113002268	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
702113002269	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
702113002270	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
702113002271	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
702113002272	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
702113002273	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
702113002274	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
702113002275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
702113002276	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
702113002277	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
702113002278	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
702113002279	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
702113002280	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
702113002281	Mg++ binding site [ion binding]; other site
702113002282	putative catalytic motif [active]
702113002283	putative substrate binding site [chemical binding]; other site
702113002284	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
702113002285	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
702113002286	cell division protein FtsW; Region: ftsW; TIGR02614
702113002287	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
702113002288	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
702113002289	active site
702113002290	homodimer interface [polypeptide binding]; other site
702113002291	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
702113002292	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
702113002293	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
702113002294	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
702113002295	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
702113002296	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
702113002297	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113002298	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
702113002299	Cell division protein FtsQ; Region: FtsQ; pfam03799
702113002300	Cell division protein FtsA; Region: FtsA; smart00842
702113002301	cell division protein FtsA; Region: ftsA; TIGR01174
702113002302	Cell division protein FtsA; Region: FtsA; pfam14450
702113002303	cell division protein FtsZ; Validated; Region: PRK09330
702113002304	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
702113002305	nucleotide binding site [chemical binding]; other site
702113002306	SulA interaction site; other site
702113002307	Tetratricopeptide repeat; Region: TPR_16; pfam13432
702113002308	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113002309	binding surface
702113002310	TPR motif; other site
702113002311	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
702113002312	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
702113002313	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
702113002314	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
702113002315	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
702113002316	GTPase CgtA; Reviewed; Region: obgE; PRK12299
702113002317	GTP1/OBG; Region: GTP1_OBG; pfam01018
702113002318	Obg GTPase; Region: Obg; cd01898
702113002319	G1 box; other site
702113002320	GTP/Mg2+ binding site [chemical binding]; other site
702113002321	Switch I region; other site
702113002322	G2 box; other site
702113002323	G3 box; other site
702113002324	Switch II region; other site
702113002325	G4 box; other site
702113002326	G5 box; other site
702113002327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
702113002328	gamma-glutamyl kinase; Provisional; Region: PRK05429
702113002329	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
702113002330	nucleotide binding site [chemical binding]; other site
702113002331	substrate binding site [chemical binding]; other site
702113002332	PUA domain; Region: PUA; pfam01472
702113002333	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113002334	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113002335	NAD(P) binding site [chemical binding]; other site
702113002336	active site
702113002337	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113002338	HAMP domain; Region: HAMP; pfam00672
702113002339	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
702113002340	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113002341	dimer interface [polypeptide binding]; other site
702113002342	putative CheW interface [polypeptide binding]; other site
702113002343	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
702113002344	putative deacylase active site [active]
702113002345	SpoVR family protein; Provisional; Region: PRK11767
702113002346	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
702113002347	hypothetical protein; Provisional; Region: PRK05325
702113002348	PrkA family serine protein kinase; Provisional; Region: PRK15455
702113002349	AAA ATPase domain; Region: AAA_16; pfam13191
702113002350	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
702113002351	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
702113002352	heme-binding site [chemical binding]; other site
702113002353	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
702113002354	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113002355	dimer interface [polypeptide binding]; other site
702113002356	putative CheW interface [polypeptide binding]; other site
702113002357	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
702113002358	Chain length determinant protein; Region: Wzz; pfam02706
702113002359	Chain length determinant protein; Region: Wzz; cl15801
702113002360	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
702113002361	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113002362	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
702113002363	colanic acid exporter; Provisional; Region: PRK10459
702113002364	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
702113002365	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
702113002366	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113002367	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113002368	active site
702113002369	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113002370	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113002371	active site
702113002372	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113002373	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
702113002374	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
702113002375	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
702113002376	trimer interface [polypeptide binding]; other site
702113002377	active site
702113002378	substrate binding site [chemical binding]; other site
702113002379	CoA binding site [chemical binding]; other site
702113002380	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
702113002381	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
702113002382	SLBB domain; Region: SLBB; pfam10531
702113002383	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113002384	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
702113002385	putative ADP-binding pocket [chemical binding]; other site
702113002386	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113002387	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
702113002388	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
702113002389	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
702113002390	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
702113002391	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
702113002392	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113002393	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113002394	active site
702113002395	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
702113002396	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113002397	active site
702113002398	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113002399	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113002400	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113002401	active site
702113002402	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
702113002403	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
702113002404	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
702113002405	Walker A/P-loop; other site
702113002406	ATP binding site [chemical binding]; other site
702113002407	Q-loop/lid; other site
702113002408	ABC transporter signature motif; other site
702113002409	Walker B; other site
702113002410	D-loop; other site
702113002411	H-loop/switch region; other site
702113002412	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
702113002413	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
702113002414	NAD binding site [chemical binding]; other site
702113002415	homodimer interface [polypeptide binding]; other site
702113002416	active site
702113002417	substrate binding site [chemical binding]; other site
702113002418	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113002419	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
702113002420	NAD binding site [chemical binding]; other site
702113002421	putative substrate binding site 2 [chemical binding]; other site
702113002422	putative substrate binding site 1 [chemical binding]; other site
702113002423	active site
702113002424	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113002425	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
702113002426	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
702113002427	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
702113002428	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113002429	active site
702113002430	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
702113002431	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
702113002432	Ligand binding site; other site
702113002433	Putative Catalytic site; other site
702113002434	DXD motif; other site
702113002435	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
702113002436	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
702113002437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113002438	NAD(P) binding site [chemical binding]; other site
702113002439	active site
702113002440	Methyltransferase domain; Region: Methyltransf_11; pfam08241
702113002441	S-adenosylmethionine binding site [chemical binding]; other site
702113002442	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
702113002443	Predicted membrane protein [Function unknown]; Region: COG2261
702113002444	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
702113002445	HSP70 interaction site [polypeptide binding]; other site
702113002446	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
702113002447	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
702113002448	NAD binding site [chemical binding]; other site
702113002449	homodimer interface [polypeptide binding]; other site
702113002450	active site
702113002451	substrate binding site [chemical binding]; other site
702113002452	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113002453	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113002454	NAD(P) binding site [chemical binding]; other site
702113002455	active site
702113002456	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
702113002457	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
702113002458	active site
702113002459	homotetramer interface [polypeptide binding]; other site
702113002460	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
702113002461	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
702113002462	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113002463	Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358
702113002464	active site
702113002465	motif I; other site
702113002466	motif II; other site
702113002467	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
702113002468	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113002469	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
702113002470	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
702113002471	Substrate binding site; other site
702113002472	Eukaryotic phosphomannomutase; Region: PMM; cl17107
702113002473	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
702113002474	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
702113002475	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
702113002476	dimerization interface [polypeptide binding]; other site
702113002477	DPS ferroxidase diiron center [ion binding]; other site
702113002478	ion pore; other site
702113002479	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
702113002480	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
702113002481	putative active site [active]
702113002482	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
702113002483	nudix motif; other site
702113002484	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
702113002485	active site
702113002486	DNA polymerase IV; Validated; Region: PRK02406
702113002487	DNA binding site [nucleotide binding]
702113002488	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113002489	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
702113002490	putative substrate translocation pore; other site
702113002491	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
702113002492	active site lid residues [active]
702113002493	substrate binding pocket [chemical binding]; other site
702113002494	catalytic residues [active]
702113002495	substrate-Mg2+ binding site; other site
702113002496	aspartate-rich region 1; other site
702113002497	aspartate-rich region 2; other site
702113002498	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
702113002499	Domain of unknown function (DUF1851); Region: DUF1851; pfam08906
702113002500	phytoene desaturase; Region: crtI_fam; TIGR02734
702113002501	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
702113002502	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
702113002503	lycopene cyclase; Region: lycopene_cycl; TIGR01789
702113002504	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
702113002505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113002506	Coenzyme A binding pocket [chemical binding]; other site
702113002507	MltA-interacting protein MipA; Region: MipA; cl01504
702113002508	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
702113002509	putative uracil binding site [chemical binding]; other site
702113002510	putative active site [active]
702113002511	Domain of unknown function (DUF4261); Region: DUF4261; pfam14080
702113002512	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
702113002513	ThiC-associated domain; Region: ThiC-associated; pfam13667
702113002514	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
702113002515	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; cl01562
702113002516	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
702113002517	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cl00333
702113002518	Predicted membrane protein [Function unknown]; Region: COG3650
702113002519	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
702113002520	Ion channel; Region: Ion_trans_2; pfam07885
702113002521	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
702113002522	TrkA-N domain; Region: TrkA_N; pfam02254
702113002523	TrkA-C domain; Region: TrkA_C; pfam02080
702113002524	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
702113002525	choline dehydrogenase; Validated; Region: PRK02106
702113002526	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113002527	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
702113002528	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
702113002529	active site
702113002530	dimer interface [polypeptide binding]; other site
702113002531	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
702113002532	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
702113002533	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
702113002534	trimer interface [polypeptide binding]; other site
702113002535	active site
702113002536	substrate binding site [chemical binding]; other site
702113002537	CoA binding site [chemical binding]; other site
702113002538	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
702113002539	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
702113002540	catalytic site [active]
702113002541	G-X2-G-X-G-K; other site
702113002542	Stringent starvation protein B; Region: SspB; pfam04386
702113002543	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
702113002544	putative active site pocket [active]
702113002545	4-fold oligomerization interface [polypeptide binding]; other site
702113002546	metal binding residues [ion binding]; metal-binding site
702113002547	3-fold/trimer interface [polypeptide binding]; other site
702113002548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350
702113002549	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
702113002550	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
702113002551	putative active site [active]
702113002552	oxyanion strand; other site
702113002553	catalytic triad [active]
702113002554	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
702113002555	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
702113002556	catalytic residues [active]
702113002557	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
702113002558	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
702113002559	substrate binding site [chemical binding]; other site
702113002560	glutamase interaction surface [polypeptide binding]; other site
702113002561	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
702113002562	metal binding site [ion binding]; metal-binding site
702113002563	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
702113002564	nucleotide binding site/active site [active]
702113002565	HIT family signature motif; other site
702113002566	catalytic residue [active]
702113002567	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
702113002568	active site
702113002569	TolQ protein; Region: tolQ; TIGR02796
702113002570	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
702113002571	TolR protein; Region: tolR; TIGR02801
702113002572	translocation protein TolB; Provisional; Region: tolB; PRK05137
702113002573	TolB amino-terminal domain; Region: TolB_N; pfam04052
702113002574	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
702113002575	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
702113002576	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
702113002577	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113002578	ligand binding site [chemical binding]; other site
702113002579	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
702113002580	HSP70 interaction site [polypeptide binding]; other site
702113002581	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
702113002582	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
702113002583	transmembrane helices; other site
702113002584	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
702113002585	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
702113002586	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
702113002587	metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123
702113002588	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113002589	active site
702113002590	metal binding site [ion binding]; metal-binding site
702113002591	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
702113002592	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752
702113002593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113002594	metabolite-proton symporter; Region: 2A0106; TIGR00883
702113002595	putative substrate translocation pore; other site
702113002596	putative MFS family transporter protein; Provisional; Region: PRK03633
702113002597	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113002598	putative substrate translocation pore; other site
702113002599	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113002600	MarR family; Region: MarR; pfam01047
702113002601	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
702113002602	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
702113002603	Zn2+ binding site [ion binding]; other site
702113002604	Mg2+ binding site [ion binding]; other site
702113002605	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
702113002606	synthetase active site [active]
702113002607	NTP binding site [chemical binding]; other site
702113002608	metal binding site [ion binding]; metal-binding site
702113002609	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
702113002610	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
702113002611	Domain of unknown function (DUF1905); Region: DUF1905; pfam08922
702113002612	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
702113002613	active site
702113002614	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
702113002615	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
702113002616	active site
702113002617	Int/Topo IB signature motif; other site
702113002618	Integrase core domain; Region: rve; pfam00665
702113002619	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
702113002620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113002621	Walker A motif; other site
702113002622	ATP binding site [chemical binding]; other site
702113002623	Walker B motif; other site
702113002624	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113002625	active site
702113002626	Int/Topo IB signature motif; other site
702113002627	DNA binding site [nucleotide binding]
702113002628	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
702113002629	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
702113002630	GTP binding site; other site
702113002631	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113002632	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113002633	DNA binding site [nucleotide binding]
702113002634	aminotransferase; Validated; Region: PRK09148
702113002635	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113002636	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113002637	homodimer interface [polypeptide binding]; other site
702113002638	catalytic residue [active]
702113002639	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
702113002640	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
702113002641	Phasin protein; Region: Phasin_2; pfam09361
702113002642	Uncharacterized conserved protein [Function unknown]; Region: COG2127
702113002643	Predicted permeases [General function prediction only]; Region: COG0795
702113002644	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
702113002645	Predicted permeases [General function prediction only]; Region: COG0795
702113002646	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
702113002647	Fatty acid desaturase; Region: FA_desaturase; pfam00487
702113002648	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
702113002649	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113002650	Coenzyme A binding pocket [chemical binding]; other site
702113002651	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
702113002652	lipoate-protein ligase B; Provisional; Region: PRK14341
702113002653	Methyltransferase domain; Region: Methyltransf_31; pfam13847
702113002654	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113002655	S-adenosylmethionine binding site [chemical binding]; other site
702113002656	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
702113002657	ArsC family; Region: ArsC; pfam03960
702113002658	catalytic residues [active]
702113002659	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
702113002660	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113002661	catalytic loop [active]
702113002662	iron binding site [ion binding]; other site
702113002663	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
702113002664	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
702113002665	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113002666	N-terminal plug; other site
702113002667	ligand-binding site [chemical binding]; other site
702113002668	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
702113002669	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
702113002670	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
702113002671	Ligand binding site; other site
702113002672	metal-binding site
702113002673	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
702113002674	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
702113002675	XdhC Rossmann domain; Region: XdhC_C; pfam13478
702113002676	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
702113002677	Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553
702113002678	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
702113002679	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
702113002680	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
702113002681	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113002682	Walker A/P-loop; other site
702113002683	ATP binding site [chemical binding]; other site
702113002684	Q-loop/lid; other site
702113002685	ABC transporter signature motif; other site
702113002686	Walker B; other site
702113002687	D-loop; other site
702113002688	H-loop/switch region; other site
702113002689	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
702113002690	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
702113002691	active site
702113002692	Zn binding site [ion binding]; other site
702113002693	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
702113002694	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
702113002695	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
702113002696	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
702113002697	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
702113002698	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
702113002699	putative catalytic site [active]
702113002700	putative phosphate binding site [ion binding]; other site
702113002701	active site
702113002702	metal binding site A [ion binding]; metal-binding site
702113002703	DNA binding site [nucleotide binding]
702113002704	putative AP binding site [nucleotide binding]; other site
702113002705	putative metal binding site B [ion binding]; other site
702113002706	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
702113002707	dimerization interface [polypeptide binding]; other site
702113002708	active site
702113002709	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
702113002710	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
702113002711	Predicted membrane protein [Function unknown]; Region: COG4325
702113002712	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113002713	EamA-like transporter family; Region: EamA; pfam00892
702113002714	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
702113002715	pseudouridine synthase; Region: TIGR00093
702113002716	active site
702113002717	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113002718	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
702113002719	C-terminal domain interface [polypeptide binding]; other site
702113002720	GSH binding site (G-site) [chemical binding]; other site
702113002721	dimer interface [polypeptide binding]; other site
702113002722	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
702113002723	N-terminal domain interface [polypeptide binding]; other site
702113002724	dimer interface [polypeptide binding]; other site
702113002725	substrate binding pocket (H-site) [chemical binding]; other site
702113002726	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
702113002727	NADH(P)-binding; Region: NAD_binding_10; pfam13460
702113002728	putative NAD(P) binding site [chemical binding]; other site
702113002729	active site
702113002730	Predicted membrane protein [Function unknown]; Region: COG2259
702113002731	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
702113002732	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
702113002733	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
702113002734	RNA polymerase sigma factor; Provisional; Region: PRK12547
702113002735	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113002736	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113002737	DNA binding residues [nucleotide binding]
702113002738	CHASE domain; Region: CHASE; pfam03924
702113002739	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113002740	HWE histidine kinase; Region: HWE_HK; pfam07536
702113002741	two-component response regulator; Provisional; Region: PRK09191
702113002742	Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712
702113002743	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
702113002744	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113002745	active site
702113002746	phosphorylation site [posttranslational modification]
702113002747	intermolecular recognition site; other site
702113002748	dimerization interface [polypeptide binding]; other site
702113002749	RNA polymerase sigma factor; Provisional; Region: PRK12547
702113002750	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113002751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113002752	DNA binding residues [nucleotide binding]
702113002753	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113002754	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113002755	active site
702113002756	phosphorylation site [posttranslational modification]
702113002757	intermolecular recognition site; other site
702113002758	dimerization interface [polypeptide binding]; other site
702113002759	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
702113002760	Hemerythrin-like domain; Region: Hr-like; cd12108
702113002761	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
702113002762	GAF domain; Region: GAF; pfam01590
702113002763	Phytochrome region; Region: PHY; pfam00360
702113002764	HWE histidine kinase; Region: HWE_HK; pfam07536
702113002765	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113002766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113002767	active site
702113002768	phosphorylation site [posttranslational modification]
702113002769	intermolecular recognition site; other site
702113002770	dimerization interface [polypeptide binding]; other site
702113002771	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
702113002772	heme binding pocket [chemical binding]; other site
702113002773	heme ligand [chemical binding]; other site
702113002774	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113002775	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
702113002776	ligand binding site [chemical binding]; other site
702113002777	flexible hinge region; other site
702113002778	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
702113002779	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
702113002780	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113002781	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
702113002782	NAD(P) binding site [chemical binding]; other site
702113002783	active site
702113002784	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
702113002785	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
702113002786	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
702113002787	Protein export membrane protein; Region: SecD_SecF; cl14618
702113002788	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
702113002789	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113002790	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113002791	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113002792	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113002793	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113002794	substrate binding site [chemical binding]; other site
702113002795	oxyanion hole (OAH) forming residues; other site
702113002796	trimer interface [polypeptide binding]; other site
702113002797	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113002798	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113002799	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113002800	dimerization interface [polypeptide binding]; other site
702113002801	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
702113002802	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
702113002803	substrate binding site [chemical binding]; other site
702113002804	catalytic Zn binding site [ion binding]; other site
702113002805	NAD binding site [chemical binding]; other site
702113002806	structural Zn binding site [ion binding]; other site
702113002807	dimer interface [polypeptide binding]; other site
702113002808	S-formylglutathione hydrolase; Region: PLN02442
702113002809	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
702113002810	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
702113002811	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
702113002812	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
702113002813	allantoate amidohydrolase; Reviewed; Region: PRK09290
702113002814	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
702113002815	active site
702113002816	metal binding site [ion binding]; metal-binding site
702113002817	dimer interface [polypeptide binding]; other site
702113002818	WYL domain; Region: WYL; pfam13280
702113002819	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
702113002820	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
702113002821	active site
702113002822	dimer interface [polypeptide binding]; other site
702113002823	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
702113002824	Ligand Binding Site [chemical binding]; other site
702113002825	Molecular Tunnel; other site
702113002826	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
702113002827	aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670
702113002828	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
702113002829	Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Region: SLC5sbd_DUR3; cd11476
702113002830	Na binding site [ion binding]; other site
702113002831	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113002832	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113002833	putative DNA binding site [nucleotide binding]; other site
702113002834	putative Zn2+ binding site [ion binding]; other site
702113002835	AsnC family; Region: AsnC_trans_reg; pfam01037
702113002836	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
702113002837	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
702113002838	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
702113002839	Glutamate binding site [chemical binding]; other site
702113002840	NAD binding site [chemical binding]; other site
702113002841	catalytic residues [active]
702113002842	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
702113002843	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
702113002844	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113002845	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113002846	putative substrate translocation pore; other site
702113002847	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
702113002848	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
702113002849	Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988
702113002850	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
702113002851	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
702113002852	Active Sites [active]
702113002853	Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073
702113002854	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
702113002855	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
702113002856	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
702113002857	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
702113002858	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
702113002859	active site
702113002860	SAM binding site [chemical binding]; other site
702113002861	homodimer interface [polypeptide binding]; other site
702113002862	PilZ domain; Region: PilZ; pfam07238
702113002863	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113002864	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113002865	non-specific DNA binding site [nucleotide binding]; other site
702113002866	salt bridge; other site
702113002867	sequence-specific DNA binding site [nucleotide binding]; other site
702113002868	PAS fold; Region: PAS_4; pfam08448
702113002869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113002870	putative active site [active]
702113002871	heme pocket [chemical binding]; other site
702113002872	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113002873	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113002874	metal binding site [ion binding]; metal-binding site
702113002875	active site
702113002876	I-site; other site
702113002877	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113002878	cystathionine beta-lyase; Provisional; Region: PRK09028
702113002879	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113002880	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113002881	catalytic residue [active]
702113002882	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
702113002883	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
702113002884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113002885	Coenzyme A binding pocket [chemical binding]; other site
702113002886	Predicted amidohydrolase [General function prediction only]; Region: COG0388
702113002887	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
702113002888	putative active site [active]
702113002889	catalytic triad [active]
702113002890	putative dimer interface [polypeptide binding]; other site
702113002891	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
702113002892	transmembrane helices; other site
702113002893	TrkA-C domain; Region: TrkA_C; pfam02080
702113002894	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
702113002895	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
702113002896	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
702113002897	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
702113002898	Zn2+ binding site [ion binding]; other site
702113002899	Mg2+ binding site [ion binding]; other site
702113002900	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
702113002901	PilZ domain; Region: PilZ; pfam07238
702113002902	Domain of unknown function (DUF389); Region: DUF389; pfam04087
702113002903	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
702113002904	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
702113002905	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
702113002906	active site
702113002907	catalytic site [active]
702113002908	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
702113002909	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
702113002910	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
702113002911	homodimer interface [polypeptide binding]; other site
702113002912	active site pocket [active]
702113002913	glycogen branching enzyme; Provisional; Region: PRK05402
702113002914	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
702113002915	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
702113002916	active site
702113002917	catalytic site [active]
702113002918	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
702113002919	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
702113002920	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
702113002921	ligand binding site; other site
702113002922	oligomer interface; other site
702113002923	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
702113002924	dimer interface [polypeptide binding]; other site
702113002925	N-terminal domain interface [polypeptide binding]; other site
702113002926	sulfate 1 binding site; other site
702113002927	glycogen synthase; Provisional; Region: glgA; PRK00654
702113002928	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
702113002929	ADP-binding pocket [chemical binding]; other site
702113002930	homodimer interface [polypeptide binding]; other site
702113002931	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
702113002932	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
702113002933	active site
702113002934	catalytic site [active]
702113002935	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
702113002936	ANTAR domain; Region: ANTAR; pfam03861
702113002937	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
702113002938	NMT1-like family; Region: NMT1_2; pfam13379
702113002939	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
702113002940	NMT1-like family; Region: NMT1_2; pfam13379
702113002941	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
702113002942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113002943	dimer interface [polypeptide binding]; other site
702113002944	conserved gate region; other site
702113002945	putative PBP binding loops; other site
702113002946	ABC-ATPase subunit interface; other site
702113002947	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
702113002948	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
702113002949	Walker A/P-loop; other site
702113002950	ATP binding site [chemical binding]; other site
702113002951	Q-loop/lid; other site
702113002952	ABC transporter signature motif; other site
702113002953	Walker B; other site
702113002954	D-loop; other site
702113002955	H-loop/switch region; other site
702113002956	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
702113002957	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
702113002958	Walker A/P-loop; other site
702113002959	ATP binding site [chemical binding]; other site
702113002960	Q-loop/lid; other site
702113002961	ABC transporter signature motif; other site
702113002962	Walker B; other site
702113002963	D-loop; other site
702113002964	H-loop/switch region; other site
702113002965	coproporphyrinogen III oxidase; Provisional; Region: PRK06582
702113002966	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
702113002967	Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631
702113002968	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
702113002969	Catalytic domain of Protein Kinases; Region: PKc; cd00180
702113002970	active site
702113002971	ATP binding site [chemical binding]; other site
702113002972	substrate binding site [chemical binding]; other site
702113002973	activation loop (A-loop); other site
702113002974	cyanate hydratase; Validated; Region: PRK02866
702113002975	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
702113002976	oligomer interface [polypeptide binding]; other site
702113002977	active site
702113002978	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
702113002979	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113002980	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
702113002981	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
702113002982	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
702113002983	[2Fe-2S] cluster binding site [ion binding]; other site
702113002984	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
702113002985	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
702113002986	[4Fe-4S] binding site [ion binding]; other site
702113002987	molybdopterin cofactor binding site; other site
702113002988	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
702113002989	molybdopterin cofactor binding site; other site
702113002990	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
702113002991	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
702113002992	active site
702113002993	SAM binding site [chemical binding]; other site
702113002994	homodimer interface [polypeptide binding]; other site
702113002995	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
702113002996	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113002997	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113002998	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113002999	DNA binding residues [nucleotide binding]
702113003000	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
702113003001	active site
702113003002	catalytic residues [active]
702113003003	Proline dehydrogenase; Region: Pro_dh; cl03282
702113003004	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
702113003005	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113003006	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113003007	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
702113003008	active site
702113003009	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113003010	extended (e) SDRs; Region: SDR_e; cd08946
702113003011	NAD(P) binding site [chemical binding]; other site
702113003012	active site
702113003013	substrate binding site [chemical binding]; other site
702113003014	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
702113003015	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113003016	Methyltransferase domain; Region: Methyltransf_12; pfam08242
702113003017	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
702113003018	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113003019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113003020	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
702113003021	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
702113003022	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
702113003023	Ligand binding site; other site
702113003024	metal-binding site
702113003025	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
702113003026	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
702113003027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113003028	active site
702113003029	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
702113003030	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
702113003031	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
702113003032	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
702113003033	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
702113003034	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113003035	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113003036	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
702113003037	putative ADP-binding pocket [chemical binding]; other site
702113003038	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
702113003039	Chain length determinant protein; Region: Wzz; cl15801
702113003040	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
702113003041	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113003042	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
702113003043	Bacterial sugar transferase; Region: Bac_transf; pfam02397
702113003044	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
702113003045	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
702113003046	SLBB domain; Region: SLBB; pfam10531
702113003047	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113003048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113003049	active site
702113003050	phosphorylation site [posttranslational modification]
702113003051	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113003052	DNA binding residues [nucleotide binding]
702113003053	dimerization interface [polypeptide binding]; other site
702113003054	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
702113003055	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
702113003056	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
702113003057	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113003058	FAD binding domain; Region: FAD_binding_2; pfam00890
702113003059	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
702113003060	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
702113003061	substrate binding site [chemical binding]; other site
702113003062	isopropylmalate isomerase large subunit; Provisional; Region: PRK12466
702113003063	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
702113003064	substrate binding site [chemical binding]; other site
702113003065	ligand binding site [chemical binding]; other site
702113003066	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113003067	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113003068	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
702113003069	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113003070	DNA-binding site [nucleotide binding]; DNA binding site
702113003071	UTRA domain; Region: UTRA; pfam07702
702113003072	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
702113003073	active site
702113003074	catalytic residues [active]
702113003075	metal binding site [ion binding]; metal-binding site
702113003076	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
702113003077	Isochorismatase family; Region: Isochorismatase; pfam00857
702113003078	catalytic triad [active]
702113003079	conserved cis-peptide bond; other site
702113003080	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
702113003081	putative active site [active]
702113003082	putative catalytic site [active]
702113003083	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
702113003084	putative active site [active]
702113003085	putative catalytic site [active]
702113003086	SnoaL-like domain; Region: SnoaL_2; pfam12680
702113003087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003088	putative substrate translocation pore; other site
702113003089	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113003090	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113003091	classical (c) SDRs; Region: SDR_c; cd05233
702113003092	NAD(P) binding site [chemical binding]; other site
702113003093	active site
702113003094	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113003095	homotrimer interaction site [polypeptide binding]; other site
702113003096	putative active site [active]
702113003097	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113003098	putative active site [active]
702113003099	homotrimer interaction site [polypeptide binding]; other site
702113003100	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113003101	homotrimer interaction site [polypeptide binding]; other site
702113003102	putative active site [active]
702113003103	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003104	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003105	N-terminal plug; other site
702113003106	ligand-binding site [chemical binding]; other site
702113003107	Methyltransferase domain; Region: Methyltransf_31; pfam13847
702113003108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113003109	S-adenosylmethionine binding site [chemical binding]; other site
702113003110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113003111	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
702113003112	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
702113003113	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
702113003114	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113003115	active site
702113003116	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
702113003117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003118	NAD(P) binding site [chemical binding]; other site
702113003119	active site
702113003120	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113003121	FAD binding domain; Region: FAD_binding_3; pfam01494
702113003122	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
702113003123	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113003124	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
702113003125	NAD(P) binding site [chemical binding]; other site
702113003126	catalytic residues [active]
702113003127	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
702113003128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113003129	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113003130	Protein of unknown function (DUF3089); Region: DUF3089; pfam11288
702113003131	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003132	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003133	N-terminal plug; other site
702113003134	ligand-binding site [chemical binding]; other site
702113003135	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113003136	S-adenosylmethionine binding site [chemical binding]; other site
702113003137	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113003138	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113003139	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
702113003140	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
702113003141	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
702113003142	tetramer interface [polypeptide binding]; other site
702113003143	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
702113003144	active site
702113003145	Mg2+/Mn2+ binding site [ion binding]; other site
702113003146	Isochorismatase family; Region: Isochorismatase; pfam00857
702113003147	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
702113003148	catalytic triad [active]
702113003149	conserved cis-peptide bond; other site
702113003150	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113003151	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113003152	active site
702113003153	metal binding site [ion binding]; metal-binding site
702113003154	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
702113003155	substrate binding pocket [chemical binding]; other site
702113003156	active site
702113003157	Isochorismatase family; Region: Isochorismatase; pfam00857
702113003158	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
702113003159	catalytic triad [active]
702113003160	conserved cis-peptide bond; other site
702113003161	short chain dehydrogenase; Provisional; Region: PRK06180
702113003162	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003163	NAD(P) binding site [chemical binding]; other site
702113003164	active site
702113003165	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
702113003166	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
702113003167	substrate binding site [chemical binding]; other site
702113003168	dimer interface [polypeptide binding]; other site
702113003169	ATP binding site [chemical binding]; other site
702113003170	pyrimidine utilization protein A; Region: RutA; TIGR03612
702113003171	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
702113003172	Isochorismatase family; Region: Isochorismatase; pfam00857
702113003173	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
702113003174	catalytic triad [active]
702113003175	conserved cis-peptide bond; other site
702113003176	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113003177	M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896
702113003178	acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910
702113003179	putative metal binding site [ion binding]; other site
702113003180	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113003181	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113003182	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
702113003183	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
702113003184	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
702113003185	active site
702113003186	iron coordination sites [ion binding]; other site
702113003187	substrate binding pocket [chemical binding]; other site
702113003188	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
702113003189	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
702113003190	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
702113003191	putative active site [active]
702113003192	metal binding site [ion binding]; metal-binding site
702113003193	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113003194	active site
702113003195	metal binding site [ion binding]; metal-binding site
702113003196	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003197	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003198	[2Fe-2S] cluster binding site [ion binding]; other site
702113003199	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
702113003200	hydrophobic ligand binding site; other site
702113003201	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003202	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003203	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003204	N-terminal plug; other site
702113003205	ligand-binding site [chemical binding]; other site
702113003206	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113003207	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113003208	active site
702113003209	catalytic tetrad [active]
702113003210	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
702113003211	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
702113003212	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
702113003213	ApbE family; Region: ApbE; pfam02424
702113003214	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
702113003215	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
702113003216	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
702113003217	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
702113003218	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
702113003219	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
702113003220	Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774
702113003221	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003222	N-terminal plug; other site
702113003223	ligand-binding site [chemical binding]; other site
702113003224	Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467
702113003225	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113003226	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113003227	metal binding site [ion binding]; metal-binding site
702113003228	active site
702113003229	I-site; other site
702113003230	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
702113003231	GAF domain; Region: GAF; pfam01590
702113003232	PAS domain S-box; Region: sensory_box; TIGR00229
702113003233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113003234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113003235	metal binding site [ion binding]; metal-binding site
702113003236	active site
702113003237	I-site; other site
702113003238	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113003239	malonyl-CoA synthase; Validated; Region: PRK07514
702113003240	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
702113003241	acyl-activating enzyme (AAE) consensus motif; other site
702113003242	active site
702113003243	AMP binding site [chemical binding]; other site
702113003244	CoA binding site [chemical binding]; other site
702113003245	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
702113003246	nudix motif; other site
702113003247	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
702113003248	putative GSH binding site [chemical binding]; other site
702113003249	catalytic residues [active]
702113003250	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
702113003251	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
702113003252	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
702113003253	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
702113003254	substrate binding site [chemical binding]; other site
702113003255	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
702113003256	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
702113003257	substrate binding site [chemical binding]; other site
702113003258	ligand binding site [chemical binding]; other site
702113003259	beta-carotene hydroxylase; Region: PLN02601
702113003260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
702113003261	Fe-S metabolism associated domain; Region: SufE; cl00951
702113003262	NAD synthetase; Reviewed; Region: nadE; PRK02628
702113003263	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
702113003264	multimer interface [polypeptide binding]; other site
702113003265	active site
702113003266	catalytic triad [active]
702113003267	protein interface 1 [polypeptide binding]; other site
702113003268	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
702113003269	homodimer interface [polypeptide binding]; other site
702113003270	NAD binding pocket [chemical binding]; other site
702113003271	ATP binding pocket [chemical binding]; other site
702113003272	Mg binding site [ion binding]; other site
702113003273	active-site loop [active]
702113003274	PspC domain; Region: PspC; pfam04024
702113003275	phage shock protein C; Region: phageshock_pspC; TIGR02978
702113003276	phage shock protein A; Region: phageshock_pspA; TIGR02977
702113003277	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
702113003278	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113003279	Walker A motif; other site
702113003280	ATP binding site [chemical binding]; other site
702113003281	Walker B motif; other site
702113003282	arginine finger; other site
702113003283	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
702113003284	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113003285	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113003286	DNA binding residues [nucleotide binding]
702113003287	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
702113003288	MPN+ (JAMM) motif; other site
702113003289	Zinc-binding site [ion binding]; other site
702113003290	hypothetical protein; Provisional; Region: PRK14636
702113003291	Sm and related proteins; Region: Sm_like; cl00259
702113003292	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
702113003293	putative oligomer interface [polypeptide binding]; other site
702113003294	putative RNA binding site [nucleotide binding]; other site
702113003295	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
702113003296	NusA N-terminal domain; Region: NusA_N; pfam08529
702113003297	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
702113003298	RNA binding site [nucleotide binding]; other site
702113003299	homodimer interface [polypeptide binding]; other site
702113003300	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
702113003301	G-X-X-G motif; other site
702113003302	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
702113003303	G-X-X-G motif; other site
702113003304	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
702113003305	hypothetical protein; Provisional; Region: PRK09190
702113003306	Protein of unknown function (DUF448); Region: DUF448; pfam04296
702113003307	putative RNA binding cleft [nucleotide binding]; other site
702113003308	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
702113003309	translation initiation factor IF-2; Region: IF-2; TIGR00487
702113003310	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
702113003311	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
702113003312	G1 box; other site
702113003313	putative GEF interaction site [polypeptide binding]; other site
702113003314	GTP/Mg2+ binding site [chemical binding]; other site
702113003315	Switch I region; other site
702113003316	G2 box; other site
702113003317	G3 box; other site
702113003318	Switch II region; other site
702113003319	G4 box; other site
702113003320	G5 box; other site
702113003321	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
702113003322	Translation-initiation factor 2; Region: IF-2; pfam11987
702113003323	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
702113003324	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
702113003325	Domain of unknown function (DUF1963); Region: DUF1963; cl01600
702113003326	thymidine kinase; Provisional; Region: PRK04296
702113003327	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
702113003328	Peptidase family M50; Region: Peptidase_M50; pfam02163
702113003329	active site
702113003330	putative substrate binding region [chemical binding]; other site
702113003331	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
702113003332	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
702113003333	RNA binding site [nucleotide binding]; other site
702113003334	active site
702113003335	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
702113003336	16S/18S rRNA binding site [nucleotide binding]; other site
702113003337	S13e-L30e interaction site [polypeptide binding]; other site
702113003338	25S rRNA binding site [nucleotide binding]; other site
702113003339	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
702113003340	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
702113003341	RNase E interface [polypeptide binding]; other site
702113003342	trimer interface [polypeptide binding]; other site
702113003343	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
702113003344	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
702113003345	RNase E interface [polypeptide binding]; other site
702113003346	trimer interface [polypeptide binding]; other site
702113003347	active site
702113003348	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
702113003349	putative nucleic acid binding region [nucleotide binding]; other site
702113003350	G-X-X-G motif; other site
702113003351	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
702113003352	RNA binding site [nucleotide binding]; other site
702113003353	domain interface; other site
702113003354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003355	putative substrate translocation pore; other site
702113003356	Transcriptional regulators [Transcription]; Region: MarR; COG1846
702113003357	MarR family; Region: MarR_2; pfam12802
702113003358	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
702113003359	short chain dehydrogenase; Provisional; Region: PRK06500
702113003360	classical (c) SDRs; Region: SDR_c; cd05233
702113003361	NAD(P) binding site [chemical binding]; other site
702113003362	active site
702113003363	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
702113003364	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003365	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
702113003366	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113003367	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
702113003368	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
702113003369	Trp docking motif [polypeptide binding]; other site
702113003370	active site
702113003371	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113003372	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113003373	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
702113003374	NADH(P)-binding; Region: NAD_binding_10; pfam13460
702113003375	NADP binding site [chemical binding]; other site
702113003376	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113003377	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113003378	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113003379	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
702113003380	FAD binding domain; Region: FAD_binding_4; pfam01565
702113003381	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
702113003382	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
702113003383	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003384	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003385	N-terminal plug; other site
702113003386	ligand-binding site [chemical binding]; other site
702113003387	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
702113003388	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113003389	C-terminal domain interface [polypeptide binding]; other site
702113003390	GSH binding site (G-site) [chemical binding]; other site
702113003391	dimer interface [polypeptide binding]; other site
702113003392	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113003393	N-terminal domain interface [polypeptide binding]; other site
702113003394	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113003395	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
702113003396	C-terminal domain interface [polypeptide binding]; other site
702113003397	GSH binding site (G-site) [chemical binding]; other site
702113003398	dimer interface [polypeptide binding]; other site
702113003399	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113003400	N-terminal domain interface [polypeptide binding]; other site
702113003401	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
702113003402	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
702113003403	Trp docking motif [polypeptide binding]; other site
702113003404	cytochrome domain interface [polypeptide binding]; other site
702113003405	active site
702113003406	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113003407	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
702113003408	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003409	classical (c) SDRs; Region: SDR_c; cd05233
702113003410	NAD(P) binding site [chemical binding]; other site
702113003411	active site
702113003412	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
702113003413	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113003414	dimer interface [polypeptide binding]; other site
702113003415	putative metal binding site [ion binding]; other site
702113003416	hypothetical protein; Provisional; Region: PRK06194
702113003417	classical (c) SDRs; Region: SDR_c; cd05233
702113003418	NAD(P) binding site [chemical binding]; other site
702113003419	active site
702113003420	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
702113003421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113003422	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113003423	salt bridge; other site
702113003424	non-specific DNA binding site [nucleotide binding]; other site
702113003425	sequence-specific DNA binding site [nucleotide binding]; other site
702113003426	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003427	putative transporter; Provisional; Region: PRK10504
702113003428	putative substrate translocation pore; other site
702113003429	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
702113003430	active site
702113003431	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
702113003432	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
702113003433	C-terminal domain interface [polypeptide binding]; other site
702113003434	GSH binding site (G-site) [chemical binding]; other site
702113003435	dimer interface [polypeptide binding]; other site
702113003436	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113003437	N-terminal domain interface [polypeptide binding]; other site
702113003438	dimer interface [polypeptide binding]; other site
702113003439	substrate binding pocket (H-site) [chemical binding]; other site
702113003440	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113003441	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
702113003442	C-terminal domain interface [polypeptide binding]; other site
702113003443	GSH binding site (G-site) [chemical binding]; other site
702113003444	dimer interface [polypeptide binding]; other site
702113003445	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113003446	N-terminal domain interface [polypeptide binding]; other site
702113003447	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
702113003448	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113003449	putative C-terminal domain interface [polypeptide binding]; other site
702113003450	putative GSH binding site (G-site) [chemical binding]; other site
702113003451	putative dimer interface [polypeptide binding]; other site
702113003452	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
702113003453	putative N-terminal domain interface [polypeptide binding]; other site
702113003454	putative dimer interface [polypeptide binding]; other site
702113003455	putative substrate binding pocket (H-site) [chemical binding]; other site
702113003456	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113003457	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
702113003458	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
702113003459	N-terminal domain interface [polypeptide binding]; other site
702113003460	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
702113003461	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113003462	NAD binding site [chemical binding]; other site
702113003463	catalytic residues [active]
702113003464	classical (c) SDRs; Region: SDR_c; cd05233
702113003465	NAD(P) binding site [chemical binding]; other site
702113003466	active site
702113003467	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113003468	benzoate transport; Region: 2A0115; TIGR00895
702113003469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003470	putative substrate translocation pore; other site
702113003471	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113003472	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113003473	active site
702113003474	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113003475	MarR family; Region: MarR_2; pfam12802
702113003476	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
702113003477	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
702113003478	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003479	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003480	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
702113003481	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
702113003482	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113003483	tetramerization interface [polypeptide binding]; other site
702113003484	NAD(P) binding site [chemical binding]; other site
702113003485	catalytic residues [active]
702113003486	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113003487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003488	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113003489	putative substrate translocation pore; other site
702113003490	hypothetical protein; Provisional; Region: PRK06194
702113003491	classical (c) SDRs; Region: SDR_c; cd05233
702113003492	NAD(P) binding site [chemical binding]; other site
702113003493	active site
702113003494	hypothetical protein; Provisional; Region: PRK06194
702113003495	classical (c) SDRs; Region: SDR_c; cd05233
702113003496	NAD(P) binding site [chemical binding]; other site
702113003497	active site
702113003498	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113003499	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113003500	DNA binding site [nucleotide binding]
702113003501	domain linker motif; other site
702113003502	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113003503	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113003504	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113003505	non-specific DNA binding site [nucleotide binding]; other site
702113003506	salt bridge; other site
702113003507	sequence-specific DNA binding site [nucleotide binding]; other site
702113003508	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113003509	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113003510	active site
702113003511	phosphorylation site [posttranslational modification]
702113003512	intermolecular recognition site; other site
702113003513	dimerization interface [polypeptide binding]; other site
702113003514	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113003515	DNA binding residues [nucleotide binding]
702113003516	dimerization interface [polypeptide binding]; other site
702113003517	Histidine kinase; Region: HisKA_3; pfam07730
702113003518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113003519	ATP binding site [chemical binding]; other site
702113003520	Mg2+ binding site [ion binding]; other site
702113003521	G-X-G motif; other site
702113003522	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
702113003523	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
702113003524	substrate binding site [chemical binding]; other site
702113003525	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
702113003526	substrate binding site [chemical binding]; other site
702113003527	ligand binding site [chemical binding]; other site
702113003528	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113003529	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003530	iron-sulfur cluster [ion binding]; other site
702113003531	[2Fe-2S] cluster binding site [ion binding]; other site
702113003532	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
702113003533	hydrophobic ligand binding site; other site
702113003534	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003535	putative substrate translocation pore; other site
702113003536	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113003537	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113003538	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
702113003539	hypothetical protein; Provisional; Region: PRK07236
702113003540	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113003541	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113003542	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003543	WHG domain; Region: WHG; pfam13305
702113003544	Protein of unknown function (DUF1134); Region: DUF1134; pfam06577
702113003545	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
702113003546	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113003547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113003548	homodimer interface [polypeptide binding]; other site
702113003549	catalytic residue [active]
702113003550	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
702113003551	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
702113003552	Lumazine binding domain; Region: Lum_binding; pfam00677
702113003553	Lumazine binding domain; Region: Lum_binding; pfam00677
702113003554	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
702113003555	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
702113003556	catalytic motif [active]
702113003557	Zn binding site [ion binding]; other site
702113003558	RibD C-terminal domain; Region: RibD_C; cl17279
702113003559	Protein of unknown function DUF45; Region: DUF45; pfam01863
702113003560	hypothetical protein; Provisional; Region: PRK05170
702113003561	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
702113003562	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
702113003563	Cu(I) binding site [ion binding]; other site
702113003564	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
702113003565	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
702113003566	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
702113003567	COQ9; Region: COQ9; pfam08511
702113003568	FeoA domain; Region: FeoA; pfam04023
702113003569	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
702113003570	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
702113003571	G1 box; other site
702113003572	GTP/Mg2+ binding site [chemical binding]; other site
702113003573	Switch I region; other site
702113003574	G2 box; other site
702113003575	G3 box; other site
702113003576	Switch II region; other site
702113003577	G4 box; other site
702113003578	G5 box; other site
702113003579	Nucleoside recognition; Region: Gate; pfam07670
702113003580	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
702113003581	Nucleoside recognition; Region: Gate; pfam07670
702113003582	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
702113003583	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
702113003584	dimer interface [polypeptide binding]; other site
702113003585	ssDNA binding site [nucleotide binding]; other site
702113003586	tetramer (dimer of dimers) interface [polypeptide binding]; other site
702113003587	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003588	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003589	N-terminal plug; other site
702113003590	ligand-binding site [chemical binding]; other site
702113003591	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113003592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003593	WHG domain; Region: WHG; pfam13305
702113003594	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
702113003595	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; pfam03981
702113003596	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
702113003597	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
702113003598	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
702113003599	active site
702113003600	HslU subunit interaction site [polypeptide binding]; other site
702113003601	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
702113003602	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113003603	Walker A motif; other site
702113003604	ATP binding site [chemical binding]; other site
702113003605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113003606	Walker B motif; other site
702113003607	arginine finger; other site
702113003608	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
702113003609	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
702113003610	high affinity sulphate transporter 1; Region: sulP; TIGR00815
702113003611	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
702113003612	Sulfate transporter family; Region: Sulfate_transp; pfam00916
702113003613	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
702113003614	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
702113003615	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
702113003616	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113003617	Walker A/P-loop; other site
702113003618	ATP binding site [chemical binding]; other site
702113003619	Q-loop/lid; other site
702113003620	ABC transporter signature motif; other site
702113003621	Walker B; other site
702113003622	D-loop; other site
702113003623	H-loop/switch region; other site
702113003624	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
702113003625	catalytic motif [active]
702113003626	Catalytic residue [active]
702113003627	Aspartyl protease; Region: Asp_protease_2; pfam13650
702113003628	Core-2/I-Branching enzyme; Region: Branch; pfam02485
702113003629	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
702113003630	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
702113003631	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
702113003632	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113003633	active site
702113003634	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113003635	potential protein location (putative uncharacterized protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113003636	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113003637	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (23S ribosomal RNA)
702113003638	DDE domain; Region: DDE_Tnp_IS240; pfam13610
702113003639	Integrase core domain; Region: rve; pfam00665
702113003640	Integrase core domain; Region: rve_3; pfam13683
702113003641	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
702113003642	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
702113003643	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113003644	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003645	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113003646	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113003647	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
702113003648	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
702113003649	active site
702113003650	Fe binding site [ion binding]; other site
702113003651	shikimate 5-dehydrogenase; Reviewed; Region: PRK12549
702113003652	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
702113003653	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
702113003654	shikimate binding site; other site
702113003655	NAD(P) binding site [chemical binding]; other site
702113003656	benzoate transport; Region: 2A0115; TIGR00895
702113003657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003658	putative substrate translocation pore; other site
702113003659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003660	Tannase and feruloyl esterase; Region: Tannase; pfam07519
702113003661	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113003662	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113003663	active site
702113003664	Integrase core domain; Region: rve; pfam00665
702113003665	DDE domain; Region: DDE_Tnp_IS240; pfam13610
702113003666	Integrase core domain; Region: rve; pfam00665
702113003667	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113003668	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003669	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003670	N-terminal plug; other site
702113003671	ligand-binding site [chemical binding]; other site
702113003672	Protein of unknown function (DUF1330); Region: DUF1330; pfam07045
702113003673	hypothetical protein; Provisional; Region: PRK08204
702113003674	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113003675	active site
702113003676	fumarylacetoacetase; Region: PLN02856
702113003677	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
702113003678	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113003679	acyl-CoA synthetase; Validated; Region: PRK08162
702113003680	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
702113003681	acyl-activating enzyme (AAE) consensus motif; other site
702113003682	putative active site [active]
702113003683	AMP binding site [chemical binding]; other site
702113003684	putative CoA binding site [chemical binding]; other site
702113003685	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113003686	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003687	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
702113003688	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113003689	substrate binding site [chemical binding]; other site
702113003690	oxyanion hole (OAH) forming residues; other site
702113003691	trimer interface [polypeptide binding]; other site
702113003692	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
702113003693	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113003694	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113003695	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113003696	AMP-binding enzyme; Region: AMP-binding; pfam00501
702113003697	acyl-activating enzyme (AAE) consensus motif; other site
702113003698	AMP binding site [chemical binding]; other site
702113003699	active site
702113003700	CoA binding site [chemical binding]; other site
702113003701	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
702113003702	classical (c) SDRs; Region: SDR_c; cd05233
702113003703	NAD(P) binding site [chemical binding]; other site
702113003704	active site
702113003705	EthD domain; Region: EthD; cl17553
702113003706	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
702113003707	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113003708	substrate binding site [chemical binding]; other site
702113003709	oxyanion hole (OAH) forming residues; other site
702113003710	trimer interface [polypeptide binding]; other site
702113003711	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
702113003712	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113003713	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113003714	active site
702113003715	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
702113003716	Phosphotransferase enzyme family; Region: APH; pfam01636
702113003717	putative active site [active]
702113003718	putative substrate binding site [chemical binding]; other site
702113003719	ATP binding site [chemical binding]; other site
702113003720	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003721	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003722	N-terminal plug; other site
702113003723	ligand-binding site [chemical binding]; other site
702113003724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003725	putative substrate translocation pore; other site
702113003726	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113003727	Uncharacterized conserved protein [Function unknown]; Region: COG5361
702113003728	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
702113003729	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
702113003730	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113003731	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113003732	acetyl-CoA acetyltransferase; Provisional; Region: PRK06504
702113003733	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113003734	dimer interface [polypeptide binding]; other site
702113003735	active site
702113003736	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
702113003737	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113003738	active site
702113003739	lipid-transfer protein; Provisional; Region: PRK08256
702113003740	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
702113003741	active site
702113003742	DUF35 OB-fold domain; Region: DUF35; pfam01796
702113003743	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113003744	DNA binding residues [nucleotide binding]
702113003745	dimerization interface [polypeptide binding]; other site
702113003746	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113003747	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003748	short chain dehydrogenase; Provisional; Region: PRK06949
702113003749	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003750	NAD(P) binding site [chemical binding]; other site
702113003751	active site
702113003752	classical (c) SDRs; Region: SDR_c; cd05233
702113003753	NAD(P) binding site [chemical binding]; other site
702113003754	active site
702113003755	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003756	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003757	NAD(P) binding site [chemical binding]; other site
702113003758	active site
702113003759	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113003760	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113003761	active site
702113003762	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
702113003763	Phosphotransferase enzyme family; Region: APH; pfam01636
702113003764	putative active site [active]
702113003765	putative substrate binding site [chemical binding]; other site
702113003766	ATP binding site [chemical binding]; other site
702113003767	enoyl-CoA hydratase; Provisional; Region: PRK08140
702113003768	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113003769	substrate binding site [chemical binding]; other site
702113003770	oxyanion hole (OAH) forming residues; other site
702113003771	trimer interface [polypeptide binding]; other site
702113003772	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
702113003773	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003774	classical (c) SDRs; Region: SDR_c; cd05233
702113003775	NAD(P) binding site [chemical binding]; other site
702113003776	active site
702113003777	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
702113003778	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113003779	NAD(P) binding site [chemical binding]; other site
702113003780	substrate binding site [chemical binding]; other site
702113003781	dimer interface [polypeptide binding]; other site
702113003782	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
702113003783	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
702113003784	phosphate binding site [ion binding]; other site
702113003785	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113003786	Uncharacterized conserved protein [Function unknown]; Region: COG5361
702113003787	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
702113003788	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
702113003789	Transposase IS200 like; Region: Y1_Tnp; pfam01797
702113003790	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113003791	DNA-binding site [nucleotide binding]; DNA binding site
702113003792	phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338
702113003793	FCD domain; Region: FCD; pfam07729
702113003794	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
702113003795	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003796	N-terminal plug; other site
702113003797	ligand-binding site [chemical binding]; other site
702113003798	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
702113003799	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
702113003800	putative active site [active]
702113003801	putative metal binding site [ion binding]; other site
702113003802	DctM-like transporters; Region: DctM; pfam06808
702113003803	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
702113003804	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113003805	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113003806	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
702113003807	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
702113003808	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
702113003809	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
702113003810	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113003811	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113003812	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
702113003813	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113003814	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
702113003815	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
702113003816	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
702113003817	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
702113003818	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113003819	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
702113003820	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
702113003821	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
702113003822	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113003823	catalytic loop [active]
702113003824	iron binding site [ion binding]; other site
702113003825	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
702113003826	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
702113003827	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113003828	substrate binding site [chemical binding]; other site
702113003829	oxyanion hole (OAH) forming residues; other site
702113003830	trimer interface [polypeptide binding]; other site
702113003831	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
702113003832	CoA binding domain; Region: CoA_binding_2; pfam13380
702113003833	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
702113003834	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
702113003835	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003836	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003837	N-terminal plug; other site
702113003838	ligand-binding site [chemical binding]; other site
702113003839	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113003840	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
702113003841	NAD(P) binding site [chemical binding]; other site
702113003842	catalytic residues [active]
702113003843	benzoate transport; Region: 2A0115; TIGR00895
702113003844	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113003845	putative substrate translocation pore; other site
702113003846	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
702113003847	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
702113003848	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
702113003849	Fe-S cluster binding site [ion binding]; other site
702113003850	active site
702113003851	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
702113003852	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113003853	FeS/SAM binding site; other site
702113003854	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
702113003855	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
702113003856	NAD(P) binding site [chemical binding]; other site
702113003857	SnoaL-like domain; Region: SnoaL_2; pfam12680
702113003858	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
702113003859	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113003860	NAD(P) binding site [chemical binding]; other site
702113003861	substrate binding site [chemical binding]; other site
702113003862	dimer interface [polypeptide binding]; other site
702113003863	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113003864	iron-sulfur cluster [ion binding]; other site
702113003865	[2Fe-2S] cluster binding site [ion binding]; other site
702113003866	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113003867	pyruvate dehydrogenase; Provisional; Region: PRK09124
702113003868	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
702113003869	PYR/PP interface [polypeptide binding]; other site
702113003870	dimer interface [polypeptide binding]; other site
702113003871	tetramer interface [polypeptide binding]; other site
702113003872	TPP binding site [chemical binding]; other site
702113003873	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
702113003874	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
702113003875	TPP-binding site [chemical binding]; other site
702113003876	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003877	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003878	N-terminal plug; other site
702113003879	ligand-binding site [chemical binding]; other site
702113003880	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
702113003881	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113003882	NAD(P) binding site [chemical binding]; other site
702113003883	substrate binding site [chemical binding]; other site
702113003884	dimer interface [polypeptide binding]; other site
702113003885	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003886	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003887	NAD(P) binding site [chemical binding]; other site
702113003888	active site
702113003889	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003890	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003891	N-terminal plug; other site
702113003892	ligand-binding site [chemical binding]; other site
702113003893	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
702113003894	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113003895	NAD(P) binding site [chemical binding]; other site
702113003896	substrate binding site [chemical binding]; other site
702113003897	dimer interface [polypeptide binding]; other site
702113003898	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003899	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003900	[2Fe-2S] cluster binding site [ion binding]; other site
702113003901	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
702113003902	putative alpha subunit interface [polypeptide binding]; other site
702113003903	putative active site [active]
702113003904	putative substrate binding site [chemical binding]; other site
702113003905	Fe binding site [ion binding]; other site
702113003906	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003907	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003908	[2Fe-2S] cluster binding site [ion binding]; other site
702113003909	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113003910	putative alpha subunit interface [polypeptide binding]; other site
702113003911	putative active site [active]
702113003912	putative substrate binding site [chemical binding]; other site
702113003913	Fe binding site [ion binding]; other site
702113003914	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003915	classical (c) SDRs; Region: SDR_c; cd05233
702113003916	NAD(P) binding site [chemical binding]; other site
702113003917	active site
702113003918	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113003919	classical (c) SDRs; Region: SDR_c; cd05233
702113003920	NAD(P) binding site [chemical binding]; other site
702113003921	active site
702113003922	hypothetical protein; Validated; Region: PRK07121
702113003923	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113003924	cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295
702113003925	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
702113003926	acyl-activating enzyme (AAE) consensus motif; other site
702113003927	putative AMP binding site [chemical binding]; other site
702113003928	putative active site [active]
702113003929	putative CoA binding site [chemical binding]; other site
702113003930	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003931	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003932	[2Fe-2S] cluster binding site [ion binding]; other site
702113003933	C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887
702113003934	putative alpha subunit interface [polypeptide binding]; other site
702113003935	putative active site [active]
702113003936	putative substrate binding site [chemical binding]; other site
702113003937	Fe binding site [ion binding]; other site
702113003938	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
702113003939	EthD domain; Region: EthD; pfam07110
702113003940	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113003941	C factor cell-cell signaling protein; Provisional; Region: PRK09009
702113003942	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
702113003943	NADP binding site [chemical binding]; other site
702113003944	homodimer interface [polypeptide binding]; other site
702113003945	active site
702113003946	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003947	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003948	[2Fe-2S] cluster binding site [ion binding]; other site
702113003949	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113003950	putative alpha subunit interface [polypeptide binding]; other site
702113003951	putative active site [active]
702113003952	putative substrate binding site [chemical binding]; other site
702113003953	Fe binding site [ion binding]; other site
702113003954	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113003955	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113003956	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113003957	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113003958	N-terminal plug; other site
702113003959	ligand-binding site [chemical binding]; other site
702113003960	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003961	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003962	[2Fe-2S] cluster binding site [ion binding]; other site
702113003963	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113003964	putative alpha subunit interface [polypeptide binding]; other site
702113003965	putative active site [active]
702113003966	putative substrate binding site [chemical binding]; other site
702113003967	Fe binding site [ion binding]; other site
702113003968	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
702113003969	substrate binding site [chemical binding]; other site
702113003970	metal binding site [ion binding]; metal-binding site
702113003971	dimer interface [polypeptide binding]; other site
702113003972	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113003973	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113003974	[2Fe-2S] cluster binding site [ion binding]; other site
702113003975	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113003976	putative alpha subunit interface [polypeptide binding]; other site
702113003977	putative active site [active]
702113003978	putative substrate binding site [chemical binding]; other site
702113003979	Fe binding site [ion binding]; other site
702113003980	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113003981	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003982	short chain dehydrogenase; Validated; Region: PRK07069
702113003983	NAD(P) binding site [chemical binding]; other site
702113003984	active site
702113003985	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113003986	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113003987	active site
702113003988	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003989	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113003990	NAD(P) binding site [chemical binding]; other site
702113003991	active site
702113003992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003993	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113003994	NAD(P) binding site [chemical binding]; other site
702113003995	active site
702113003996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113003997	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113003998	NAD(P) binding site [chemical binding]; other site
702113003999	active site
702113004000	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113004001	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113004002	[2Fe-2S] cluster binding site [ion binding]; other site
702113004003	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113004004	putative alpha subunit interface [polypeptide binding]; other site
702113004005	putative active site [active]
702113004006	putative substrate binding site [chemical binding]; other site
702113004007	Fe binding site [ion binding]; other site
702113004008	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
702113004009	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
702113004010	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113004011	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113004012	active site
702113004013	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113004014	DNA binding residues [nucleotide binding]
702113004015	dimerization interface [polypeptide binding]; other site
702113004016	choline dehydrogenase; Validated; Region: PRK02106
702113004017	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113004018	DUF35 OB-fold domain; Region: DUF35; pfam01796
702113004019	lipid-transfer protein; Provisional; Region: PRK08256
702113004020	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
702113004021	active site
702113004022	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
702113004023	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113004024	active site
702113004025	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
702113004026	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
702113004027	tetramer interface [polypeptide binding]; other site
702113004028	TPP-binding site [chemical binding]; other site
702113004029	heterodimer interface [polypeptide binding]; other site
702113004030	phosphorylation loop region [posttranslational modification]
702113004031	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
702113004032	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
702113004033	alpha subunit interface [polypeptide binding]; other site
702113004034	TPP binding site [chemical binding]; other site
702113004035	heterodimer interface [polypeptide binding]; other site
702113004036	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113004037	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
702113004038	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113004039	E3 interaction surface; other site
702113004040	lipoyl attachment site [posttranslational modification]; other site
702113004041	e3 binding domain; Region: E3_binding; pfam02817
702113004042	e3 binding domain; Region: E3_binding; pfam02817
702113004043	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
702113004044	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113004045	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113004046	active site
702113004047	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113004048	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113004049	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113004050	active site
702113004051	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
702113004052	Phosphotransferase enzyme family; Region: APH; pfam01636
702113004053	putative active site [active]
702113004054	putative substrate binding site [chemical binding]; other site
702113004055	ATP binding site [chemical binding]; other site
702113004056	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
702113004057	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113004058	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113004059	P-loop; other site
702113004060	Magnesium ion binding site [ion binding]; other site
702113004061	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113004062	FtsH Extracellular; Region: FtsH_ext; pfam06480
702113004063	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
702113004064	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113004065	Walker A motif; other site
702113004066	ATP binding site [chemical binding]; other site
702113004067	Walker B motif; other site
702113004068	arginine finger; other site
702113004069	Peptidase family M41; Region: Peptidase_M41; pfam01434
702113004070	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
702113004071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113004072	Histidine kinase; Region: HisKA_2; pfam07568
702113004073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113004074	ATP binding site [chemical binding]; other site
702113004075	Mg2+ binding site [ion binding]; other site
702113004076	G-X-G motif; other site
702113004077	hypothetical protein; Provisional; Region: PRK08912
702113004078	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113004079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113004080	homodimer interface [polypeptide binding]; other site
702113004081	catalytic residue [active]
702113004082	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
702113004083	TrkA-C domain; Region: TrkA_C; pfam02080
702113004084	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
702113004085	TrkA-C domain; Region: TrkA_C; pfam02080
702113004086	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
702113004087	NRDE protein; Region: NRDE; cl01315
702113004088	hypothetical protein; Reviewed; Region: PRK00024
702113004089	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
702113004090	MPN+ (JAMM) motif; other site
702113004091	Zinc-binding site [ion binding]; other site
702113004092	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
702113004093	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
702113004094	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
702113004095	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
702113004096	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
702113004097	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
702113004098	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
702113004099	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
702113004100	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
702113004101	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
702113004102	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
702113004103	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
702113004104	RNA binding site [nucleotide binding]; other site
702113004105	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
702113004106	RNA binding site [nucleotide binding]; other site
702113004107	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
702113004108	RNA binding site [nucleotide binding]; other site
702113004109	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
702113004110	RNA binding site [nucleotide binding]; other site
702113004111	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
702113004112	RNA binding site [nucleotide binding]; other site
702113004113	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
702113004114	RNA binding site [nucleotide binding]; other site
702113004115	cytidylate kinase; Provisional; Region: cmk; PRK00023
702113004116	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
702113004117	CMP-binding site; other site
702113004118	The sites determining sugar specificity; other site
702113004119	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
702113004120	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
702113004121	hinge; other site
702113004122	active site
702113004123	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
702113004124	TIGR02300 family protein; Region: FYDLN_acid
702113004125	signal recognition particle protein; Provisional; Region: PRK10867
702113004126	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
702113004127	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
702113004128	P loop; other site
702113004129	GTP binding site [chemical binding]; other site
702113004130	Signal peptide binding domain; Region: SRP_SPB; pfam02978
702113004131	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
702113004132	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
702113004133	RimM N-terminal domain; Region: RimM; pfam01782
702113004134	PRC-barrel domain; Region: PRC; pfam05239
702113004135	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
702113004136	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113004137	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113004138	dimerization interface [polypeptide binding]; other site
702113004139	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
702113004140	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
702113004141	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
702113004142	IHF dimer interface [polypeptide binding]; other site
702113004143	IHF - DNA interface [nucleotide binding]; other site
702113004144	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
702113004145	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
702113004146	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
702113004147	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
702113004148	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
702113004149	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
702113004150	CDP-alcohol phosphatidyltransferase 2; Region: CDP-OH_P_tran_2; pfam08009
702113004151	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
702113004152	rRNA interaction site [nucleotide binding]; other site
702113004153	S8 interaction site; other site
702113004154	putative laminin-1 binding site; other site
702113004155	elongation factor Ts; Provisional; Region: tsf; PRK09377
702113004156	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
702113004157	Elongation factor TS; Region: EF_TS; pfam00889
702113004158	Elongation factor TS; Region: EF_TS; pfam00889
702113004159	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113004160	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
702113004161	putative nucleotide binding site [chemical binding]; other site
702113004162	uridine monophosphate binding site [chemical binding]; other site
702113004163	homohexameric interface [polypeptide binding]; other site
702113004164	ribosome recycling factor; Reviewed; Region: frr; PRK00083
702113004165	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
702113004166	hinge region; other site
702113004167	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
702113004168	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
702113004169	catalytic residue [active]
702113004170	putative FPP diphosphate  binding site; other site
702113004171	putative FPP binding hydrophobic cleft; other site
702113004172	dimer interface [polypeptide binding]; other site
702113004173	putative IPP diphosphate binding site; other site
702113004174	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
702113004175	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
702113004176	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
702113004177	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
702113004178	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
702113004179	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
702113004180	RIP metalloprotease RseP; Region: TIGR00054
702113004181	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
702113004182	active site
702113004183	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
702113004184	protein binding site [polypeptide binding]; other site
702113004185	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
702113004186	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
702113004187	putative substrate binding region [chemical binding]; other site
702113004188	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
702113004189	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113004190	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113004191	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113004192	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113004193	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113004194	Surface antigen; Region: Bac_surface_Ag; pfam01103
702113004195	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
702113004196	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
702113004197	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
702113004198	PilZ domain; Region: PilZ; pfam07238
702113004199	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
702113004200	E-class dimer interface [polypeptide binding]; other site
702113004201	P-class dimer interface [polypeptide binding]; other site
702113004202	active site
702113004203	Cu2+ binding site [ion binding]; other site
702113004204	Zn2+ binding site [ion binding]; other site
702113004205	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
702113004206	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
702113004207	CcmE; Region: CcmE; pfam03100
702113004208	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
702113004209	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
702113004210	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
702113004211	catalytic residues [active]
702113004212	central insert; other site
702113004213	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
702113004214	TPR repeat; Region: TPR_11; pfam13414
702113004215	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113004216	TPR motif; other site
702113004217	binding surface
702113004218	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
702113004219	potassium uptake protein; Region: kup; TIGR00794
702113004220	Predicted membrane protein [Function unknown]; Region: COG3748
702113004221	Intracellular septation protein A; Region: IspA; pfam04279
702113004222	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
702113004223	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
702113004224	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
702113004225	P loop; other site
702113004226	GTP binding site [chemical binding]; other site
702113004227	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
702113004228	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
702113004229	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
702113004230	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
702113004231	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
702113004232	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113004233	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113004234	metal binding site [ion binding]; metal-binding site
702113004235	active site
702113004236	I-site; other site
702113004237	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113004238	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
702113004239	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
702113004240	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
702113004241	EVE domain; Region: EVE; pfam01878
702113004242	CsbD-like; Region: CsbD; cl17424
702113004243	H+ Antiporter protein; Region: 2A0121; TIGR00900
702113004244	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
702113004245	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
702113004246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113004247	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
702113004248	dimerization interface [polypeptide binding]; other site
702113004249	ribonuclease D; Region: rnd; TIGR01388
702113004250	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
702113004251	catalytic site [active]
702113004252	putative active site [active]
702113004253	putative substrate binding site [chemical binding]; other site
702113004254	HRDC domain; Region: HRDC; pfam00570
702113004255	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
702113004256	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
702113004257	dimer interface [polypeptide binding]; other site
702113004258	anticodon binding site; other site
702113004259	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
702113004260	homodimer interface [polypeptide binding]; other site
702113004261	motif 1; other site
702113004262	active site
702113004263	motif 2; other site
702113004264	GAD domain; Region: GAD; pfam02938
702113004265	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
702113004266	active site
702113004267	motif 3; other site
702113004268	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113004269	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
702113004270	acyl carrier protein; Provisional; Region: acpP; PRK00982
702113004271	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
702113004272	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
702113004273	dimer interface [polypeptide binding]; other site
702113004274	active site
702113004275	YceG-like family; Region: YceG; pfam02618
702113004276	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
702113004277	dimerization interface [polypeptide binding]; other site
702113004278	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
702113004279	integrase; Provisional; Region: PRK09692
702113004280	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
702113004281	active site
702113004282	Int/Topo IB signature motif; other site
702113004283	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
702113004284	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113004285	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113004286	catalytic residue [active]
702113004287	CHC2 zinc finger; Region: zf-CHC2; cl17510
702113004288	Toprim domain; Region: Toprim_3; pfam13362
702113004289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113004290	S-adenosylmethionine binding site [chemical binding]; other site
702113004291	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
702113004292	Helicase_C-like; Region: Helicase_C_4; pfam13871
702113004293	RES domain; Region: RES; smart00953
702113004294	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
702113004295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113004296	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
702113004297	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
702113004298	DNA binding residues [nucleotide binding]
702113004299	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
702113004300	dimer interface [polypeptide binding]; other site
702113004301	putative metal binding site [ion binding]; other site
702113004302	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
702113004303	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
702113004304	Uncharacterized conserved protein [Function unknown]; Region: COG1742
702113004305	arsenical pump membrane protein; Provisional; Region: PRK15445
702113004306	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
702113004307	transmembrane helices; other site
702113004308	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
702113004309	ArsC family; Region: ArsC; pfam03960
702113004310	catalytic residues [active]
702113004311	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
702113004312	Low molecular weight phosphatase family; Region: LMWPc; cd00115
702113004313	active site
702113004314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113004315	putative DNA binding site [nucleotide binding]; other site
702113004316	putative Zn2+ binding site [ion binding]; other site
702113004317	ParB-like nuclease domain; Region: ParBc; pfam02195
702113004318	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
702113004319	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
702113004320	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
702113004321	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
702113004322	Int/Topo IB signature motif; other site
702113004323	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113004324	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113004325	active site
702113004326	DNA binding site [nucleotide binding]
702113004327	Int/Topo IB signature motif; other site
702113004328	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
702113004329	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
702113004330	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
702113004331	Int/Topo IB signature motif; other site
702113004332	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113004333	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
702113004334	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
702113004335	dimer interface [polypeptide binding]; other site
702113004336	ssDNA binding site [nucleotide binding]; other site
702113004337	tetramer (dimer of dimers) interface [polypeptide binding]; other site
702113004338	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113004339	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
702113004340	Walker A motif; other site
702113004341	ATP binding site [chemical binding]; other site
702113004342	Walker B motif; other site
702113004343	TrwC relaxase; Region: TrwC; pfam08751
702113004344	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
702113004345	AAA domain; Region: AAA_30; pfam13604
702113004346	Predicted transcriptional regulator [Transcription]; Region: COG2932
702113004347	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
702113004348	Catalytic site [active]
702113004349	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113004350	ligand binding site [chemical binding]; other site
702113004351	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
702113004352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113004353	ATP binding site [chemical binding]; other site
702113004354	putative Mg++ binding site [ion binding]; other site
702113004355	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113004356	nucleotide binding region [chemical binding]; other site
702113004357	ATP-binding site [chemical binding]; other site
702113004358	DEAD-like helicases superfamily; Region: DEXDc; smart00487
702113004359	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113004360	ATP binding site [chemical binding]; other site
702113004361	putative Mg++ binding site [ion binding]; other site
702113004362	helicase superfamily c-terminal domain; Region: HELICc; smart00490
702113004363	nucleotide binding region [chemical binding]; other site
702113004364	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
702113004365	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
702113004366	tellurite resistance protein terB; Region: terB; cd07176
702113004367	putative metal binding site [ion binding]; other site
702113004368	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
702113004369	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
702113004370	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113004371	ATP binding site [chemical binding]; other site
702113004372	putative Mg++ binding site [ion binding]; other site
702113004373	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113004374	nucleotide binding region [chemical binding]; other site
702113004375	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
702113004376	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
702113004377	conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283
702113004378	F plasmid transfer operon protein; Region: TraF; pfam13728
702113004379	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
702113004380	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
702113004381	TraU protein; Region: TraU; pfam06834
702113004382	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
702113004383	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
702113004384	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
702113004385	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
702113004386	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
702113004387	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
702113004388	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
702113004389	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
702113004390	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
702113004391	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
702113004392	dimerization domain [polypeptide binding]; other site
702113004393	dimer interface [polypeptide binding]; other site
702113004394	catalytic residues [active]
702113004395	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113004396	TraK protein; Region: TraK; pfam06586
702113004397	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
702113004398	TraE protein; Region: TraE; pfam05309
702113004399	TraL protein; Region: TraL; pfam07178
702113004400	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
702113004401	Transcriptional regulator [Transcription]; Region: IclR; COG1414
702113004402	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113004403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113004404	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
702113004405	putative substrate translocation pore; other site
702113004406	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113004407	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113004408	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
702113004409	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113004410	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113004411	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113004412	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
702113004413	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113004414	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
702113004415	FAD binding domain; Region: FAD_binding_4; pfam01565
702113004416	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
702113004417	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
702113004418	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113004419	Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150
702113004420	NAD(P) binding site [chemical binding]; other site
702113004421	catalytic residues [active]
702113004422	FAD binding domain; Region: FAD_binding_4; pfam01565
702113004423	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
702113004424	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
702113004425	Flavoprotein; Region: Flavoprotein; pfam02441
702113004426	succinic semialdehyde dehydrogenase; Region: PLN02278
702113004427	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
702113004428	tetramerization interface [polypeptide binding]; other site
702113004429	NAD(P) binding site [chemical binding]; other site
702113004430	catalytic residues [active]
702113004431	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113004432	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113004433	N-terminal plug; other site
702113004434	ligand-binding site [chemical binding]; other site
702113004435	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113004436	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113004437	N-terminal plug; other site
702113004438	ligand-binding site [chemical binding]; other site
702113004439	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
702113004440	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
702113004441	putative catalytic residue [active]
702113004442	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113004443	Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545
702113004444	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
702113004445	putative alpha subunit interface [polypeptide binding]; other site
702113004446	putative active site [active]
702113004447	putative substrate binding site [chemical binding]; other site
702113004448	Fe binding site [ion binding]; other site
702113004449	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004450	inter-subunit interface; other site
702113004451	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
702113004452	[2Fe-2S] cluster binding site [ion binding]; other site
702113004453	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113004454	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
702113004455	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
702113004456	active site
702113004457	Fe binding site [ion binding]; other site
702113004458	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113004459	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113004460	iron-sulfur cluster [ion binding]; other site
702113004461	[2Fe-2S] cluster binding site [ion binding]; other site
702113004462	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
702113004463	putative alpha subunit interface [polypeptide binding]; other site
702113004464	putative active site [active]
702113004465	putative substrate binding site [chemical binding]; other site
702113004466	Fe binding site [ion binding]; other site
702113004467	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004468	inter-subunit interface; other site
702113004469	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
702113004470	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; pfam04166
702113004471	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113004472	iron-sulfur cluster [ion binding]; other site
702113004473	[2Fe-2S] cluster binding site [ion binding]; other site
702113004474	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
702113004475	putative alpha subunit interface [polypeptide binding]; other site
702113004476	putative active site [active]
702113004477	putative substrate binding site [chemical binding]; other site
702113004478	Fe binding site [ion binding]; other site
702113004479	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004480	inter-subunit interface; other site
702113004481	glutathionine S-transferase; Provisional; Region: PRK10542
702113004482	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
702113004483	C-terminal domain interface [polypeptide binding]; other site
702113004484	GSH binding site (G-site) [chemical binding]; other site
702113004485	dimer interface [polypeptide binding]; other site
702113004486	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
702113004487	dimer interface [polypeptide binding]; other site
702113004488	N-terminal domain interface [polypeptide binding]; other site
702113004489	substrate binding pocket (H-site) [chemical binding]; other site
702113004490	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
702113004491	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113004492	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
702113004493	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
702113004494	tetramer interface [polypeptide binding]; other site
702113004495	C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
702113004496	tetramer interface [polypeptide binding]; other site
702113004497	active site
702113004498	Fe binding site [ion binding]; other site
702113004499	Domain of unknown function (DUF336); Region: DUF336; pfam03928
702113004500	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
702113004501	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
702113004502	NAD binding site [chemical binding]; other site
702113004503	catalytic residues [active]
702113004504	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113004505	acetaldehyde dehydrogenase; Validated; Region: PRK08300
702113004506	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113004507	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
702113004508	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
702113004509	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
702113004510	active site
702113004511	catalytic residues [active]
702113004512	metal binding site [ion binding]; metal-binding site
702113004513	DmpG-like communication domain; Region: DmpG_comm; pfam07836
702113004514	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113004515	Tautomerase enzyme; Region: Tautomerase; pfam01361
702113004516	active site 1 [active]
702113004517	dimer interface [polypeptide binding]; other site
702113004518	hexamer interface [polypeptide binding]; other site
702113004519	active site 2 [active]
702113004520	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
702113004521	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113004522	NAD(P) binding site [chemical binding]; other site
702113004523	catalytic residues [active]
702113004524	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
702113004525	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113004526	NAD(P) binding site [chemical binding]; other site
702113004527	active site
702113004528	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
702113004529	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113004530	catalytic loop [active]
702113004531	iron binding site [ion binding]; other site
702113004532	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
702113004533	FAD binding pocket [chemical binding]; other site
702113004534	FAD binding motif [chemical binding]; other site
702113004535	phosphate binding motif [ion binding]; other site
702113004536	beta-alpha-beta structure motif; other site
702113004537	NAD binding pocket [chemical binding]; other site
702113004538	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
702113004539	Di-iron ligands [ion binding]; other site
702113004540	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004541	inter-subunit interface; other site
702113004542	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113004543	iron-sulfur cluster [ion binding]; other site
702113004544	[2Fe-2S] cluster binding site [ion binding]; other site
702113004545	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113004546	beta subunit interface [polypeptide binding]; other site
702113004547	alpha subunit interface [polypeptide binding]; other site
702113004548	active site
702113004549	substrate binding site [chemical binding]; other site
702113004550	Fe binding site [ion binding]; other site
702113004551	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004552	inter-subunit interface; other site
702113004553	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113004554	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113004555	iron-sulfur cluster [ion binding]; other site
702113004556	[2Fe-2S] cluster binding site [ion binding]; other site
702113004557	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113004558	beta subunit interface [polypeptide binding]; other site
702113004559	alpha subunit interface [polypeptide binding]; other site
702113004560	active site
702113004561	substrate binding site [chemical binding]; other site
702113004562	Fe binding site [ion binding]; other site
702113004563	Activator of aromatic catabolism; Region: XylR_N; pfam06505
702113004564	V4R domain; Region: V4R; pfam02830
702113004565	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113004566	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
702113004567	Walker A motif; other site
702113004568	ATP binding site [chemical binding]; other site
702113004569	Walker B motif; other site
702113004570	arginine finger; other site
702113004571	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113004572	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
702113004573	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113004574	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113004575	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
702113004576	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113004577	NAD(P) binding site [chemical binding]; other site
702113004578	active site
702113004579	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
702113004580	dihydrodipicolinate synthase; Region: dapA; TIGR00674
702113004581	putative active site [active]
702113004582	catalytic residue [active]
702113004583	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113004584	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113004585	[2Fe-2S] cluster binding site [ion binding]; other site
702113004586	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
702113004587	hydrophobic ligand binding site; other site
702113004588	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
702113004589	active site
702113004590	Amidohydrolase; Region: Amidohydro_2; pfam04909
702113004591	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113004592	homotrimer interaction site [polypeptide binding]; other site
702113004593	putative active site [active]
702113004594	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
702113004595	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
702113004596	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
702113004597	Fatty acid desaturase; Region: FA_desaturase; pfam00487
702113004598	putative di-iron ligands [ion binding]; other site
702113004599	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113004600	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113004601	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
702113004602	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113004603	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113004604	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
702113004605	acyl-activating enzyme (AAE) consensus motif; other site
702113004606	AMP binding site [chemical binding]; other site
702113004607	active site
702113004608	CoA binding site [chemical binding]; other site
702113004609	EamA-like transporter family; Region: EamA; pfam00892
702113004610	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113004611	EamA-like transporter family; Region: EamA; pfam00892
702113004612	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113004613	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113004614	iron-sulfur cluster [ion binding]; other site
702113004615	[2Fe-2S] cluster binding site [ion binding]; other site
702113004616	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113004617	beta subunit interface [polypeptide binding]; other site
702113004618	alpha subunit interface [polypeptide binding]; other site
702113004619	active site
702113004620	substrate binding site [chemical binding]; other site
702113004621	Fe binding site [ion binding]; other site
702113004622	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113004623	inter-subunit interface; other site
702113004624	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
702113004625	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
702113004626	catalytic Zn binding site [ion binding]; other site
702113004627	NAD binding site [chemical binding]; other site
702113004628	structural Zn binding site [ion binding]; other site
702113004629	pyruvate phosphate dikinase; Provisional; Region: PRK09279
702113004630	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
702113004631	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
702113004632	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113004633	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
702113004634	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
702113004635	active site
702113004636	inhibitor site; inhibition site
702113004637	dimer interface [polypeptide binding]; other site
702113004638	catalytic residue [active]
702113004639	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
702113004640	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
702113004641	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
702113004642	tartrate dehydrogenase; Provisional; Region: PRK08194
702113004643	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
702113004644	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
702113004645	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
702113004646	active site
702113004647	non-prolyl cis peptide bond; other site
702113004648	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
702113004649	BphX-like; Region: BphX; pfam06139
702113004650	DDE superfamily endonuclease; Region: DDE_5; cl17874
702113004651	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
702113004652	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
702113004653	F plasmid transfer operon protein; Region: TraF; pfam13728
702113004654	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
702113004655	catalytic residues [active]
702113004656	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
702113004657	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
702113004658	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
702113004659	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
702113004660	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722
702113004661	TraU protein; Region: TraU; pfam06834
702113004662	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
702113004663	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
702113004664	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
702113004665	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
702113004666	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113004667	conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878
702113004668	TraK protein; Region: TraK; pfam06586
702113004669	TraE protein; Region: TraE; cl05060
702113004670	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
702113004671	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
702113004672	dimerization domain [polypeptide binding]; other site
702113004673	dimer interface [polypeptide binding]; other site
702113004674	catalytic residues [active]
702113004675	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113004676	non-specific DNA binding site [nucleotide binding]; other site
702113004677	salt bridge; other site
702113004678	sequence-specific DNA binding site [nucleotide binding]; other site
702113004679	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113004680	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113004681	non-specific DNA binding site [nucleotide binding]; other site
702113004682	salt bridge; other site
702113004683	sequence-specific DNA binding site [nucleotide binding]; other site
702113004684	Transcriptional regulators [Transcription]; Region: GntR; COG1802
702113004685	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113004686	DNA-binding site [nucleotide binding]; DNA binding site
702113004687	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
702113004688	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
702113004689	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
702113004690	Ligand Binding Site [chemical binding]; other site
702113004691	Molecular Tunnel; other site
702113004692	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
702113004693	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113004694	Secretin and TonB N terminus short domain; Region: STN; pfam07660
702113004695	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
702113004696	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113004697	N-terminal plug; other site
702113004698	ligand-binding site [chemical binding]; other site
702113004699	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113004700	FecR protein; Region: FecR; pfam04773
702113004701	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
702113004702	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113004703	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113004704	DNA binding residues [nucleotide binding]
702113004705	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
702113004706	active site
702113004707	NTP binding site [chemical binding]; other site
702113004708	metal binding triad [ion binding]; metal-binding site
702113004709	antibiotic binding site [chemical binding]; other site
702113004710	Higher Eukarytoes and Prokaryotes Nucleotide-binding domain; Region: HEPN; smart00748
702113004711	Predicted transcriptional regulator [Transcription]; Region: COG3905
702113004712	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
702113004713	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
702113004714	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
702113004715	Autoinducer synthetase; Region: Autoind_synth; cl17404
702113004716	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
702113004717	Autoinducer binding domain; Region: Autoind_bind; pfam03472
702113004718	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113004719	DNA binding residues [nucleotide binding]
702113004720	dimerization interface [polypeptide binding]; other site
702113004721	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
702113004722	transcriptional regulator, y4mF family; Region: couple_hipB; TIGR03070
702113004723	integrase; Provisional; Region: PRK09692
702113004724	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
702113004725	active site
702113004726	Int/Topo IB signature motif; other site
702113004727	Helix-turn-helix domain; Region: HTH_36; pfam13730
702113004728	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
702113004729	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113004730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113004731	active site
702113004732	phosphorylation site [posttranslational modification]
702113004733	intermolecular recognition site; other site
702113004734	dimerization interface [polypeptide binding]; other site
702113004735	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113004736	DNA binding site [nucleotide binding]
702113004737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
702113004738	dimerization interface [polypeptide binding]; other site
702113004739	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113004740	dimer interface [polypeptide binding]; other site
702113004741	phosphorylation site [posttranslational modification]
702113004742	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113004743	ATP binding site [chemical binding]; other site
702113004744	Mg2+ binding site [ion binding]; other site
702113004745	G-X-G motif; other site
702113004746	Outer membrane efflux protein; Region: OEP; pfam02321
702113004747	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
702113004748	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113004749	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
702113004750	Protein export membrane protein; Region: SecD_SecF; cl14618
702113004751	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
702113004752	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
702113004753	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113004754	AAA domain; Region: AAA_23; pfam13476
702113004755	Walker A/P-loop; other site
702113004756	ATP binding site [chemical binding]; other site
702113004757	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
702113004758	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
702113004759	conserved cys residue [active]
702113004760	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113004761	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113004762	HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401
702113004763	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113004764	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
702113004765	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113004766	Domain of unknown function (DUF377); Region: DUF377; pfam04041
702113004767	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
702113004768	active site
702113004769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
702113004770	Restriction endonuclease; Region: Mrr_cat; pfam04471
702113004771	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113004772	non-specific DNA binding site [nucleotide binding]; other site
702113004773	salt bridge; other site
702113004774	sequence-specific DNA binding site [nucleotide binding]; other site
702113004775	Uncharacterized conserved protein [Function unknown]; Region: COG4933
702113004776	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113004777	Coenzyme A binding pocket [chemical binding]; other site
702113004778	Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890
702113004779	AAA domain; Region: AAA_18; pfam13238
702113004780	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
702113004781	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
702113004782	potential catalytic triad [active]
702113004783	conserved cys residue [active]
702113004784	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
702113004785	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113004786	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113004787	catalytic residue [active]
702113004788	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
702113004789	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
702113004790	elongation factor G; Reviewed; Region: PRK12740
702113004791	G1 box; other site
702113004792	putative GEF interaction site [polypeptide binding]; other site
702113004793	GTP/Mg2+ binding site [chemical binding]; other site
702113004794	Switch I region; other site
702113004795	G2 box; other site
702113004796	G3 box; other site
702113004797	Switch II region; other site
702113004798	G4 box; other site
702113004799	G5 box; other site
702113004800	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
702113004801	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
702113004802	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
702113004803	polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132
702113004804	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
702113004805	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
702113004806	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
702113004807	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
702113004808	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
702113004809	PGAP1-like protein; Region: PGAP1; pfam07819
702113004810	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113004811	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
702113004812	ABC-2 type transporter; Region: ABC2_membrane; cl17235
702113004813	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
702113004814	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; Region: Pro_isomerase; pfam00160
702113004815	active site
702113004816	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113004817	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113004818	metal binding site [ion binding]; metal-binding site
702113004819	active site
702113004820	I-site; other site
702113004821	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
702113004822	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
702113004823	S17 interaction site [polypeptide binding]; other site
702113004824	S8 interaction site; other site
702113004825	16S rRNA interaction site [nucleotide binding]; other site
702113004826	streptomycin interaction site [chemical binding]; other site
702113004827	23S rRNA interaction site [nucleotide binding]; other site
702113004828	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
702113004829	30S ribosomal protein S7; Validated; Region: PRK05302
702113004830	elongation factor G; Reviewed; Region: PRK00007
702113004831	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
702113004832	G1 box; other site
702113004833	putative GEF interaction site [polypeptide binding]; other site
702113004834	GTP/Mg2+ binding site [chemical binding]; other site
702113004835	Switch I region; other site
702113004836	G2 box; other site
702113004837	G3 box; other site
702113004838	Switch II region; other site
702113004839	G4 box; other site
702113004840	G5 box; other site
702113004841	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
702113004842	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
702113004843	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
702113004844	elongation factor Tu; Reviewed; Region: PRK00049
702113004845	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
702113004846	G1 box; other site
702113004847	GEF interaction site [polypeptide binding]; other site
702113004848	GTP/Mg2+ binding site [chemical binding]; other site
702113004849	Switch I region; other site
702113004850	G2 box; other site
702113004851	G3 box; other site
702113004852	Switch II region; other site
702113004853	G4 box; other site
702113004854	G5 box; other site
702113004855	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
702113004856	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
702113004857	Antibiotic Binding Site [chemical binding]; other site
702113004858	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
702113004859	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
702113004860	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
702113004861	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
702113004862	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
702113004863	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
702113004864	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
702113004865	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
702113004866	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
702113004867	putative translocon binding site; other site
702113004868	protein-rRNA interface [nucleotide binding]; other site
702113004869	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
702113004870	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
702113004871	G-X-X-G motif; other site
702113004872	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
702113004873	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
702113004874	23S rRNA interface [nucleotide binding]; other site
702113004875	5S rRNA interface [nucleotide binding]; other site
702113004876	putative antibiotic binding site [chemical binding]; other site
702113004877	L25 interface [polypeptide binding]; other site
702113004878	L27 interface [polypeptide binding]; other site
702113004879	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
702113004880	putative translocon interaction site; other site
702113004881	23S rRNA interface [nucleotide binding]; other site
702113004882	signal recognition particle (SRP54) interaction site; other site
702113004883	L23 interface [polypeptide binding]; other site
702113004884	trigger factor interaction site; other site
702113004885	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
702113004886	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
702113004887	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
702113004888	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
702113004889	RNA binding site [nucleotide binding]; other site
702113004890	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
702113004891	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
702113004892	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
702113004893	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
702113004894	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
702113004895	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
702113004896	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
702113004897	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
702113004898	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
702113004899	5S rRNA interface [nucleotide binding]; other site
702113004900	L5 interface [polypeptide binding]; other site
702113004901	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
702113004902	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
702113004903	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
702113004904	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
702113004905	23S rRNA binding site [nucleotide binding]; other site
702113004906	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
702113004907	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
702113004908	SecY translocase; Region: SecY; pfam00344
702113004909	adenylate kinase; Reviewed; Region: adk; PRK00279
702113004910	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
702113004911	AMP-binding site [chemical binding]; other site
702113004912	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
702113004913	Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604
702113004914	hydrophobic ligand binding site; other site
702113004915	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
702113004916	30S ribosomal protein S13; Region: bact_S13; TIGR03631
702113004917	30S ribosomal protein S11; Validated; Region: PRK05309
702113004918	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
702113004919	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
702113004920	alphaNTD - beta interaction site [polypeptide binding]; other site
702113004921	alphaNTD homodimer interface [polypeptide binding]; other site
702113004922	alphaNTD - beta' interaction site [polypeptide binding]; other site
702113004923	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
702113004924	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
702113004925	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
702113004926	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113004927	UPF0126 domain; Region: UPF0126; pfam03458
702113004928	Predicted membrane protein [Function unknown]; Region: COG2860
702113004929	UPF0126 domain; Region: UPF0126; pfam03458
702113004930	Nudix hydrolase homolog; Region: PLN02791
702113004931	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
702113004932	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
702113004933	NAD(P) binding site [chemical binding]; other site
702113004934	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
702113004935	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113004936	putative metal binding site [ion binding]; other site
702113004937	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
702113004938	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
702113004939	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
702113004940	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
702113004941	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113004942	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
702113004943	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
702113004944	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113004945	E3 interaction surface; other site
702113004946	lipoyl attachment site [posttranslational modification]; other site
702113004947	e3 binding domain; Region: E3_binding; pfam02817
702113004948	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
702113004949	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
702113004950	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
702113004951	TPP-binding site [chemical binding]; other site
702113004952	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
702113004953	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
702113004954	CoA binding domain; Region: CoA_binding; smart00881
702113004955	CoA-ligase; Region: Ligase_CoA; pfam00549
702113004956	malate dehydrogenase; Reviewed; Region: PRK06223
702113004957	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
702113004958	NAD(P) binding site [chemical binding]; other site
702113004959	dimer interface [polypeptide binding]; other site
702113004960	tetramer (dimer of dimers) interface [polypeptide binding]; other site
702113004961	substrate binding site [chemical binding]; other site
702113004962	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
702113004963	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
702113004964	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113004965	N-terminal plug; other site
702113004966	ligand-binding site [chemical binding]; other site
702113004967	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
702113004968	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
702113004969	intersubunit interface [polypeptide binding]; other site
702113004970	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
702113004971	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
702113004972	ABC-ATPase subunit  interface; other site
702113004973	dimer interface [polypeptide binding]; other site
702113004974	putative PBP binding regions; other site
702113004975	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
702113004976	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
702113004977	Walker A/P-loop; other site
702113004978	ATP binding site [chemical binding]; other site
702113004979	Q-loop/lid; other site
702113004980	ABC transporter signature motif; other site
702113004981	Walker B; other site
702113004982	D-loop; other site
702113004983	H-loop/switch region; other site
702113004984	Transcriptional regulator; Region: Rrf2; cl17282
702113004985	Rrf2 family protein; Region: rrf2_super; TIGR00738
702113004986	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
702113004987	heme-binding site [chemical binding]; other site
702113004988	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
702113004989	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
702113004990	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
702113004991	PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821
702113004992	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
702113004993	PA/protease or protease-like domain interface [polypeptide binding]; other site
702113004994	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660
702113004995	metal binding site [ion binding]; metal-binding site
702113004996	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
702113004997	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
702113004998	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
702113004999	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
702113005000	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
702113005001	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
702113005002	argininosuccinate synthase; Provisional; Region: PRK13820
702113005003	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
702113005004	ANP binding site [chemical binding]; other site
702113005005	Substrate Binding Site II [chemical binding]; other site
702113005006	Substrate Binding Site I [chemical binding]; other site
702113005007	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
702113005008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113005009	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005010	S-adenosylmethionine binding site [chemical binding]; other site
702113005011	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113005012	NAD(P) binding site [chemical binding]; other site
702113005013	active site
702113005014	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
702113005015	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
702113005016	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113005017	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113005018	metal binding site [ion binding]; metal-binding site
702113005019	active site
702113005020	I-site; other site
702113005021	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113005022	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113005023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005024	active site
702113005025	phosphorylation site [posttranslational modification]
702113005026	intermolecular recognition site; other site
702113005027	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
702113005028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113005029	putative active site [active]
702113005030	heme pocket [chemical binding]; other site
702113005031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113005032	dimer interface [polypeptide binding]; other site
702113005033	phosphorylation site [posttranslational modification]
702113005034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113005035	ATP binding site [chemical binding]; other site
702113005036	Mg2+ binding site [ion binding]; other site
702113005037	G-X-G motif; other site
702113005038	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216
702113005039	active site
702113005040	urocanate hydratase; Provisional; Region: PRK05414
702113005041	N-formylglutamate amidohydrolase; Region: FGase; cl01522
702113005042	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
702113005043	active sites [active]
702113005044	tetramer interface [polypeptide binding]; other site
702113005045	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
702113005046	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113005047	active site
702113005048	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
702113005049	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113005050	DNA-binding site [nucleotide binding]; DNA binding site
702113005051	UTRA domain; Region: UTRA; pfam07702
702113005052	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
702113005053	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
702113005054	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
702113005055	Sulfate transporter family; Region: Sulfate_transp; pfam00916
702113005056	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
702113005057	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
702113005058	active site clefts [active]
702113005059	zinc binding site [ion binding]; other site
702113005060	dimer interface [polypeptide binding]; other site
702113005061	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
702113005062	dimerization interface [polypeptide binding]; other site
702113005063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113005064	ATP binding site [chemical binding]; other site
702113005065	Mg2+ binding site [ion binding]; other site
702113005066	G-X-G motif; other site
702113005067	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113005068	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005069	active site
702113005070	phosphorylation site [posttranslational modification]
702113005071	intermolecular recognition site; other site
702113005072	dimerization interface [polypeptide binding]; other site
702113005073	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113005074	DNA binding site [nucleotide binding]
702113005075	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
702113005076	putative binding surface; other site
702113005077	active site
702113005078	Response regulator receiver domain; Region: Response_reg; pfam00072
702113005079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005080	active site
702113005081	phosphorylation site [posttranslational modification]
702113005082	intermolecular recognition site; other site
702113005083	dimerization interface [polypeptide binding]; other site
702113005084	CHASE3 domain; Region: CHASE3; cl05000
702113005085	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
702113005086	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113005087	putative active site [active]
702113005088	heme pocket [chemical binding]; other site
702113005089	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113005090	dimer interface [polypeptide binding]; other site
702113005091	phosphorylation site [posttranslational modification]
702113005092	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113005093	ATP binding site [chemical binding]; other site
702113005094	Mg2+ binding site [ion binding]; other site
702113005095	G-X-G motif; other site
702113005096	Response regulator receiver domain; Region: Response_reg; pfam00072
702113005097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005098	active site
702113005099	phosphorylation site [posttranslational modification]
702113005100	intermolecular recognition site; other site
702113005101	dimerization interface [polypeptide binding]; other site
702113005102	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113005103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005104	active site
702113005105	phosphorylation site [posttranslational modification]
702113005106	intermolecular recognition site; other site
702113005107	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005108	Response regulator receiver domain; Region: Response_reg; pfam00072
702113005109	active site
702113005110	phosphorylation site [posttranslational modification]
702113005111	intermolecular recognition site; other site
702113005112	dimerization interface [polypeptide binding]; other site
702113005113	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
702113005114	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
702113005115	anti sigma factor interaction site; other site
702113005116	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
702113005117	regulatory phosphorylation site [posttranslational modification]; other site
702113005118	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
702113005119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
702113005120	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
702113005121	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
702113005122	DXD motif; other site
702113005123	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
702113005124	Cytochrome c2 [Energy production and conversion]; Region: COG3474
702113005125	Predicted small integral membrane protein [Function unknown]; Region: COG5605
702113005126	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
702113005127	Subunit I/III interface [polypeptide binding]; other site
702113005128	Subunit I/III interface [polypeptide binding]; other site
702113005129	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
702113005130	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
702113005131	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
702113005132	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
702113005133	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
702113005134	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
702113005135	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
702113005136	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005137	active site
702113005138	phosphorylation site [posttranslational modification]
702113005139	intermolecular recognition site; other site
702113005140	dimerization interface [polypeptide binding]; other site
702113005141	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113005142	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113005143	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113005144	dimer interface [polypeptide binding]; other site
702113005145	phosphorylation site [posttranslational modification]
702113005146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113005147	ATP binding site [chemical binding]; other site
702113005148	Mg2+ binding site [ion binding]; other site
702113005149	G-X-G motif; other site
702113005150	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
702113005151	Heme/copper-type cytochrome/quinol oxidase, subunit 4 [Energy production and conversion]; Region: CyoD; COG3125
702113005152	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
702113005153	Subunit I/III interface [polypeptide binding]; other site
702113005154	Subunit III/IV interface [polypeptide binding]; other site
702113005155	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
702113005156	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
702113005157	D-pathway; other site
702113005158	Putative ubiquinol binding site [chemical binding]; other site
702113005159	Low-spin heme (heme b) binding site [chemical binding]; other site
702113005160	Putative water exit pathway; other site
702113005161	Binuclear center (heme o3/CuB) [ion binding]; other site
702113005162	K-pathway; other site
702113005163	Putative proton exit pathway; other site
702113005164	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
702113005165	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
702113005166	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
702113005167	metabolite-proton symporter; Region: 2A0106; TIGR00883
702113005168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113005169	putative substrate translocation pore; other site
702113005170	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
702113005171	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
702113005172	DNA binding residues [nucleotide binding]
702113005173	dimer interface [polypeptide binding]; other site
702113005174	copper binding site [ion binding]; other site
702113005175	YHS domain; Region: YHS; pfam04945
702113005176	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
702113005177	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113005178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113005179	motif II; other site
702113005180	fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266
702113005181	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
702113005182	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113005183	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113005184	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113005185	dimerization interface [polypeptide binding]; other site
702113005186	putative DNA binding site [nucleotide binding]; other site
702113005187	putative Zn2+ binding site [ion binding]; other site
702113005188	AsnC family; Region: AsnC_trans_reg; pfam01037
702113005189	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113005190	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113005191	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
702113005192	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
702113005193	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113005194	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113005195	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113005196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113005197	putative substrate translocation pore; other site
702113005198	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113005199	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
702113005200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005201	active site
702113005202	phosphorylation site [posttranslational modification]
702113005203	intermolecular recognition site; other site
702113005204	dimerization interface [polypeptide binding]; other site
702113005205	CheB methylesterase; Region: CheB_methylest; pfam01339
702113005206	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
702113005207	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
702113005208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113005209	ATP binding site [chemical binding]; other site
702113005210	Mg2+ binding site [ion binding]; other site
702113005211	G-X-G motif; other site
702113005212	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
702113005213	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
702113005214	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
702113005215	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
702113005216	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
702113005217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005218	active site
702113005219	phosphorylation site [posttranslational modification]
702113005220	intermolecular recognition site; other site
702113005221	CheB methylesterase; Region: CheB_methylest; pfam01339
702113005222	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
702113005223	Response regulator receiver domain; Region: Response_reg; pfam00072
702113005224	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113005225	active site
702113005226	phosphorylation site [posttranslational modification]
702113005227	intermolecular recognition site; other site
702113005228	dimerization interface [polypeptide binding]; other site
702113005229	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
702113005230	putative CheA interaction surface; other site
702113005231	Protein of unknown function (DUF938); Region: DUF938; pfam06080
702113005232	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
702113005233	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
702113005234	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
702113005235	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
702113005236	putative substrate binding site [chemical binding]; other site
702113005237	putative ATP binding site [chemical binding]; other site
702113005238	PAS domain S-box; Region: sensory_box; TIGR00229
702113005239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113005240	putative active site [active]
702113005241	heme pocket [chemical binding]; other site
702113005242	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113005243	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113005244	metal binding site [ion binding]; metal-binding site
702113005245	active site
702113005246	I-site; other site
702113005247	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113005248	isocitrate lyase; Provisional; Region: PRK15063
702113005249	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
702113005250	tetramer interface [polypeptide binding]; other site
702113005251	active site
702113005252	Mg2+/Mn2+ binding site [ion binding]; other site
702113005253	isocitrate lyase; Region: PLN02892
702113005254	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113005255	sequence-specific DNA binding site [nucleotide binding]; other site
702113005256	salt bridge; other site
702113005257	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
702113005258	Domain of unknown function (DUF955); Region: DUF955; pfam06114
702113005259	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
702113005260	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
702113005261	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
702113005262	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
702113005263	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
702113005264	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
702113005265	active site
702113005266	dimer interface [polypeptide binding]; other site
702113005267	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
702113005268	Ligand Binding Site [chemical binding]; other site
702113005269	Molecular Tunnel; other site
702113005270	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
702113005271	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113005272	acyl-CoA synthetase; Validated; Region: PRK09192
702113005273	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
702113005274	acyl-activating enzyme (AAE) consensus motif; other site
702113005275	active site
702113005276	recombination regulator RecX; Reviewed; Region: recX; PRK00117
702113005277	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
702113005278	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113005279	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113005280	NAD(P) binding site [chemical binding]; other site
702113005281	active site
702113005282	NADH dehydrogenase; Validated; Region: PRK08183
702113005283	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
702113005284	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
702113005285	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
702113005286	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
702113005287	putative homodimer interface [polypeptide binding]; other site
702113005288	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
702113005289	heterodimer interface [polypeptide binding]; other site
702113005290	homodimer interface [polypeptide binding]; other site
702113005291	Predicted acetyltransferase [General function prediction only]; Region: COG3393
702113005292	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113005293	Coenzyme A binding pocket [chemical binding]; other site
702113005294	Transcriptional regulators [Transcription]; Region: MarR; COG1846
702113005295	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113005296	putative Zn2+ binding site [ion binding]; other site
702113005297	putative DNA binding site [nucleotide binding]; other site
702113005298	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
702113005299	Acyltransferase family; Region: Acyl_transf_3; pfam01757
702113005300	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
702113005301	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
702113005302	23S rRNA interface [nucleotide binding]; other site
702113005303	L7/L12 interface [polypeptide binding]; other site
702113005304	putative thiostrepton binding site; other site
702113005305	L25 interface [polypeptide binding]; other site
702113005306	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
702113005307	mRNA/rRNA interface [nucleotide binding]; other site
702113005308	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113005309	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005310	S-adenosylmethionine binding site [chemical binding]; other site
702113005311	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
702113005312	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
702113005313	putative MPT binding site; other site
702113005314	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
702113005315	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
702113005316	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
702113005317	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
702113005318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113005319	FeS/SAM binding site; other site
702113005320	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
702113005321	Ion channel; Region: Ion_trans_2; pfam07885
702113005322	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
702113005323	TrkA-N domain; Region: TrkA_N; pfam02254
702113005324	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
702113005325	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
702113005326	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
702113005327	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
702113005328	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113005329	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
702113005330	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113005331	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
702113005332	seryl-tRNA synthetase; Provisional; Region: PRK05431
702113005333	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
702113005334	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
702113005335	dimer interface [polypeptide binding]; other site
702113005336	active site
702113005337	motif 1; other site
702113005338	motif 2; other site
702113005339	motif 3; other site
702113005340	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
702113005341	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
702113005342	CHAP domain; Region: CHAP; cl17642
702113005343	GTP-binding protein Der; Reviewed; Region: PRK00093
702113005344	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
702113005345	G1 box; other site
702113005346	GTP/Mg2+ binding site [chemical binding]; other site
702113005347	Switch I region; other site
702113005348	G2 box; other site
702113005349	Switch II region; other site
702113005350	G3 box; other site
702113005351	G4 box; other site
702113005352	G5 box; other site
702113005353	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
702113005354	G1 box; other site
702113005355	GTP/Mg2+ binding site [chemical binding]; other site
702113005356	Switch I region; other site
702113005357	G2 box; other site
702113005358	G3 box; other site
702113005359	Switch II region; other site
702113005360	G4 box; other site
702113005361	G5 box; other site
702113005362	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
702113005363	Domain of unknown function DUF20; Region: UPF0118; pfam01594
702113005364	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
702113005365	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
702113005366	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113005367	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
702113005368	FMN binding site [chemical binding]; other site
702113005369	substrate binding site [chemical binding]; other site
702113005370	putative catalytic residue [active]
702113005371	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
702113005372	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
702113005373	heme binding site [chemical binding]; other site
702113005374	ferroxidase pore; other site
702113005375	ferroxidase diiron center [ion binding]; other site
702113005376	Predicted membrane protein [Function unknown]; Region: COG2311
702113005377	Protein of unknown function (DUF418); Region: DUF418; cl12135
702113005378	Protein of unknown function (DUF418); Region: DUF418; pfam04235
702113005379	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
702113005380	Sel1-like repeats; Region: SEL1; smart00671
702113005381	Sporulation related domain; Region: SPOR; pfam05036
702113005382	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113005383	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113005384	P-loop; other site
702113005385	Magnesium ion binding site [ion binding]; other site
702113005386	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113005387	binding surface
702113005388	TPR motif; other site
702113005389	dihydroorotase; Validated; Region: pyrC; PRK09357
702113005390	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113005391	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
702113005392	active site
702113005393	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
702113005394	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
702113005395	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
702113005396	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
702113005397	tandem repeat interface [polypeptide binding]; other site
702113005398	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
702113005399	oligomer interface [polypeptide binding]; other site
702113005400	active site residues [active]
702113005401	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
702113005402	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
702113005403	tandem repeat interface [polypeptide binding]; other site
702113005404	oligomer interface [polypeptide binding]; other site
702113005405	active site residues [active]
702113005406	trigger factor; Provisional; Region: tig; PRK01490
702113005407	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
702113005408	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
702113005409	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
702113005410	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
702113005411	oligomer interface [polypeptide binding]; other site
702113005412	active site residues [active]
702113005413	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
702113005414	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
702113005415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113005416	Walker A motif; other site
702113005417	ATP binding site [chemical binding]; other site
702113005418	Walker B motif; other site
702113005419	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
702113005420	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
702113005421	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113005422	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
702113005423	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113005424	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
702113005425	Transglycosylase; Region: Transgly; cl17702
702113005426	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
702113005427	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
702113005428	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113005429	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113005430	DNA binding residues [nucleotide binding]
702113005431	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
702113005432	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
702113005433	RNA binding surface [nucleotide binding]; other site
702113005434	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
702113005435	active site
702113005436	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
702113005437	MPN+ (JAMM) motif; other site
702113005438	Zinc-binding site [ion binding]; other site
702113005439	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
702113005440	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
702113005441	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
702113005442	amidase catalytic site [active]
702113005443	Zn binding residues [ion binding]; other site
702113005444	substrate binding site [chemical binding]; other site
702113005445	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113005446	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
702113005447	active site
702113005448	metal binding site [ion binding]; metal-binding site
702113005449	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; pfam09694
702113005450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
702113005451	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113005452	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
702113005453	dimer interface [polypeptide binding]; other site
702113005454	active site
702113005455	metal binding site [ion binding]; metal-binding site
702113005456	glutathione binding site [chemical binding]; other site
702113005457	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
702113005458	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
702113005459	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113005460	active site
702113005461	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
702113005462	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
702113005463	Domain of unknown function DUF87; Region: DUF87; pfam01935
702113005464	AAA-like domain; Region: AAA_10; pfam12846
702113005465	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
702113005466	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
702113005467	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
702113005468	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113005469	FeS/SAM binding site; other site
702113005470	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
702113005471	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113005472	active site
702113005473	HIGH motif; other site
702113005474	nucleotide binding site [chemical binding]; other site
702113005475	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
702113005476	active site
702113005477	KMSKS motif; other site
702113005478	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
702113005479	tRNA binding surface [nucleotide binding]; other site
702113005480	anticodon binding site; other site
702113005481	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
702113005482	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
702113005483	anti sigma factor interaction site; other site
702113005484	regulatory phosphorylation site [posttranslational modification]; other site
702113005485	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
702113005486	Permease; Region: Permease; pfam02405
702113005487	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
702113005488	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113005489	Walker A/P-loop; other site
702113005490	ATP binding site [chemical binding]; other site
702113005491	Q-loop/lid; other site
702113005492	ABC transporter signature motif; other site
702113005493	Walker B; other site
702113005494	D-loop; other site
702113005495	H-loop/switch region; other site
702113005496	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
702113005497	mce related protein; Region: MCE; pfam02470
702113005498	Protein of unknown function (DUF330); Region: DUF330; cl01135
702113005499	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
702113005500	ATP12 chaperone protein; Region: ATP12; cl02228
702113005501	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
702113005502	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
702113005503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113005504	motif II; other site
702113005505	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
702113005506	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
702113005507	active site
702113005508	camphor resistance protein CrcB; Provisional; Region: PRK14195
702113005509	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
702113005510	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
702113005511	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
702113005512	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
702113005513	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
702113005514	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
702113005515	GatB domain; Region: GatB_Yqey; smart00845
702113005516	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
702113005517	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
702113005518	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005519	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
702113005520	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
702113005521	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005522	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
702113005523	Clp amino terminal domain; Region: Clp_N; pfam02861
702113005524	Clp amino terminal domain; Region: Clp_N; pfam02861
702113005525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113005526	Walker A motif; other site
702113005527	ATP binding site [chemical binding]; other site
702113005528	Walker B motif; other site
702113005529	arginine finger; other site
702113005530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113005531	Walker A motif; other site
702113005532	ATP binding site [chemical binding]; other site
702113005533	Walker B motif; other site
702113005534	arginine finger; other site
702113005535	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
702113005536	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113005537	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113005538	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113005539	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
702113005540	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113005541	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113005542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113005543	NAD(P) binding site [chemical binding]; other site
702113005544	active site
702113005545	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113005546	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
702113005547	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
702113005548	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
702113005549	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
702113005550	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
702113005551	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
702113005552	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
702113005553	Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476
702113005554	Type IV pili component [Cell motility and secretion]; Region: COG5461
702113005555	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
702113005556	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
702113005557	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
702113005558	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
702113005559	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
702113005560	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
702113005561	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
702113005562	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113005563	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
702113005564	hydroxyglutarate oxidase; Provisional; Region: PRK11728
702113005565	Domain of unknown function (DUF1508); Region: DUF1508; cl01356
702113005566	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
702113005567	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
702113005568	RNA/DNA hybrid binding site [nucleotide binding]; other site
702113005569	active site
702113005570	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
702113005571	Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153
702113005572	putative active site [active]
702113005573	putative substrate binding site [chemical binding]; other site
702113005574	ATP binding site [chemical binding]; other site
702113005575	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
702113005576	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
702113005577	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
702113005578	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
702113005579	putative acyl-acceptor binding pocket; other site
702113005580	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
702113005581	metal binding site 2 [ion binding]; metal-binding site
702113005582	putative DNA binding helix; other site
702113005583	metal binding site 1 [ion binding]; metal-binding site
702113005584	dimer interface [polypeptide binding]; other site
702113005585	structural Zn2+ binding site [ion binding]; other site
702113005586	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
702113005587	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
702113005588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113005589	Coenzyme A binding pocket [chemical binding]; other site
702113005590	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
702113005591	Glycoprotease family; Region: Peptidase_M22; pfam00814
702113005592	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
702113005593	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
702113005594	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
702113005595	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
702113005596	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005597	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005598	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
702113005599	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
702113005600	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
702113005601	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
702113005602	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
702113005603	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113005604	classical (c) SDRs; Region: SDR_c; cd05233
702113005605	NAD(P) binding site [chemical binding]; other site
702113005606	active site
702113005607	replicative DNA helicase; Provisional; Region: PRK09165
702113005608	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
702113005609	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
702113005610	Walker A motif; other site
702113005611	ATP binding site [chemical binding]; other site
702113005612	Walker B motif; other site
702113005613	DNA binding loops [nucleotide binding]
702113005614	hypothetical protein; Provisional; Region: PRK02853
702113005615	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599
702113005616	active site
702113005617	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
702113005618	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
702113005619	active site
702113005620	catalytic motif [active]
702113005621	Zn binding site [ion binding]; other site
702113005622	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
702113005623	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
702113005624	active site
702113005625	Zn binding site [ion binding]; other site
702113005626	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
702113005627	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
702113005628	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
702113005629	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
702113005630	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
702113005631	Uncharacterized conserved protein [Function unknown]; Region: COG2308
702113005632	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
702113005633	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
702113005634	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
702113005635	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
702113005636	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
702113005637	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
702113005638	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
702113005639	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
702113005640	phosphoserine aminotransferase; Provisional; Region: PRK03080
702113005641	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113005642	catalytic residue [active]
702113005643	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
702113005644	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
702113005645	ligand binding site [chemical binding]; other site
702113005646	NAD binding site [chemical binding]; other site
702113005647	dimerization interface [polypeptide binding]; other site
702113005648	catalytic site [active]
702113005649	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
702113005650	putative L-serine binding site [chemical binding]; other site
702113005651	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
702113005652	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
702113005653	motif 1; other site
702113005654	dimer interface [polypeptide binding]; other site
702113005655	active site
702113005656	motif 2; other site
702113005657	motif 3; other site
702113005658	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
702113005659	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
702113005660	GDP-binding site [chemical binding]; other site
702113005661	ACT binding site; other site
702113005662	IMP binding site; other site
702113005663	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113005664	NusB family; Region: NusB; pfam01029
702113005665	putative RNA binding site [nucleotide binding]; other site
702113005666	16S rRNA methyltransferase B; Provisional; Region: PRK10901
702113005667	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005668	S-adenosylmethionine binding site [chemical binding]; other site
702113005669	methionine sulfoxide reductase A; Provisional; Region: PRK14054
702113005670	Predicted methyltransferase [General function prediction only]; Region: COG4798
702113005671	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113005672	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
702113005673	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
702113005674	putative active site; other site
702113005675	catalytic triad [active]
702113005676	putative dimer interface [polypeptide binding]; other site
702113005677	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
702113005678	catalytic center binding site [active]
702113005679	ATP binding site [chemical binding]; other site
702113005680	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113005681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113005682	NAD(P) binding site [chemical binding]; other site
702113005683	active site
702113005684	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
702113005685	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
702113005686	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
702113005687	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113005688	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
702113005689	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
702113005690	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
702113005691	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
702113005692	carboxyltransferase (CT) interaction site; other site
702113005693	biotinylation site [posttranslational modification]; other site
702113005694	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
702113005695	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
702113005696	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
702113005697	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113005698	dimer interface [polypeptide binding]; other site
702113005699	putative CheW interface [polypeptide binding]; other site
702113005700	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
702113005701	HAMP domain; Region: HAMP; pfam00672
702113005702	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
702113005703	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
702113005704	TLC ATP/ADP transporter; Region: TLC; cl03940
702113005705	HEAT repeats; Region: HEAT_2; pfam13646
702113005706	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
702113005707	ligand binding site [chemical binding]; other site
702113005708	flexible hinge region; other site
702113005709	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
702113005710	anti sigma factor interaction site; other site
702113005711	regulatory phosphorylation site [posttranslational modification]; other site
702113005712	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
702113005713	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
702113005714	ATP binding site [chemical binding]; other site
702113005715	Mg2+ binding site [ion binding]; other site
702113005716	G-X-G motif; other site
702113005717	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
702113005718	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
702113005719	active site
702113005720	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113005721	substrate binding site [chemical binding]; other site
702113005722	catalytic residues [active]
702113005723	dimer interface [polypeptide binding]; other site
702113005724	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
702113005725	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
702113005726	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
702113005727	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
702113005728	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
702113005729	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
702113005730	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
702113005731	precorrin-3B synthase; Region: CobG; TIGR02435
702113005732	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
702113005733	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
702113005734	Precorrin-8X methylmutase; Region: CbiC; pfam02570
702113005735	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
702113005736	active site
702113005737	SAM binding site [chemical binding]; other site
702113005738	homodimer interface [polypeptide binding]; other site
702113005739	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
702113005740	active site
702113005741	SAM binding site [chemical binding]; other site
702113005742	homodimer interface [polypeptide binding]; other site
702113005743	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
702113005744	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
702113005745	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
702113005746	active site
702113005747	putative homodimer interface [polypeptide binding]; other site
702113005748	SAM binding site [chemical binding]; other site
702113005749	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
702113005750	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
702113005751	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
702113005752	active site
702113005753	SAM binding site [chemical binding]; other site
702113005754	homodimer interface [polypeptide binding]; other site
702113005755	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
702113005756	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113005757	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
702113005758	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
702113005759	active site
702113005760	SAM binding site [chemical binding]; other site
702113005761	homodimer interface [polypeptide binding]; other site
702113005762	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
702113005763	putative FMN binding site [chemical binding]; other site
702113005764	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113005765	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113005766	xylose isomerase; Provisional; Region: PRK05474
702113005767	xylose isomerase; Region: xylose_isom_A; TIGR02630
702113005768	xylulokinase; Provisional; Region: PRK15027
702113005769	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
702113005770	N- and C-terminal domain interface [polypeptide binding]; other site
702113005771	active site
702113005772	MgATP binding site [chemical binding]; other site
702113005773	catalytic site [active]
702113005774	metal binding site [ion binding]; metal-binding site
702113005775	xylulose binding site [chemical binding]; other site
702113005776	homodimer interface [polypeptide binding]; other site
702113005777	MFS/sugar transport protein; Region: MFS_2; pfam13347
702113005778	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
702113005779	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113005780	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113005781	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113005782	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113005783	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
702113005784	active site
702113005785	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113005786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005787	S-adenosylmethionine binding site [chemical binding]; other site
702113005788	MFS/sugar transport protein; Region: MFS_2; pfam13347
702113005789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113005790	putative substrate translocation pore; other site
702113005791	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113005792	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
702113005793	active site
702113005794	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
702113005795	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
702113005796	Isochorismatase family; Region: Isochorismatase; pfam00857
702113005797	catalytic triad [active]
702113005798	conserved cis-peptide bond; other site
702113005799	DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834
702113005800	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
702113005801	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113005802	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113005803	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113005804	N-terminal plug; other site
702113005805	ligand-binding site [chemical binding]; other site
702113005806	putative S-transferase; Provisional; Region: PRK11752
702113005807	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
702113005808	C-terminal domain interface [polypeptide binding]; other site
702113005809	GSH binding site (G-site) [chemical binding]; other site
702113005810	dimer interface [polypeptide binding]; other site
702113005811	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113005812	N-terminal domain interface [polypeptide binding]; other site
702113005813	dimer interface [polypeptide binding]; other site
702113005814	substrate binding pocket (H-site) [chemical binding]; other site
702113005815	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
702113005816	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
702113005817	homodimer interface [polypeptide binding]; other site
702113005818	substrate-cofactor binding pocket; other site
702113005819	catalytic residue [active]
702113005820	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
702113005821	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
702113005822	RNA binding surface [nucleotide binding]; other site
702113005823	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005824	S-adenosylmethionine binding site [chemical binding]; other site
702113005825	TspO/MBR family; Region: TspO_MBR; pfam03073
702113005826	Membrane fusogenic activity; Region: BMFP; pfam04380
702113005827	Recombination protein O N terminal; Region: RecO_N; pfam11967
702113005828	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
702113005829	tartrate dehydrogenase; Region: TTC; TIGR02089
702113005830	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
702113005831	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
702113005832	Ligand binding site; other site
702113005833	Putative Catalytic site; other site
702113005834	DXD motif; other site
702113005835	Predicted membrane protein [Function unknown]; Region: COG2246
702113005836	GtrA-like protein; Region: GtrA; pfam04138
702113005837	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
702113005838	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
702113005839	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
702113005840	homodimer interface [polypeptide binding]; other site
702113005841	substrate-cofactor binding pocket; other site
702113005842	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113005843	catalytic residue [active]
702113005844	PAS domain; Region: PAS_9; pfam13426
702113005845	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113005846	putative active site [active]
702113005847	heme pocket [chemical binding]; other site
702113005848	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113005849	HWE histidine kinase; Region: HWE_HK; smart00911
702113005850	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
702113005851	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113005852	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113005853	dimerization interface [polypeptide binding]; other site
702113005854	Peptidase family M48; Region: Peptidase_M48; cl12018
702113005855	enoyl-CoA hydratase; Provisional; Region: PRK05981
702113005856	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113005857	substrate binding site [chemical binding]; other site
702113005858	oxyanion hole (OAH) forming residues; other site
702113005859	trimer interface [polypeptide binding]; other site
702113005860	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113005861	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113005862	DNA binding site [nucleotide binding]
702113005863	domain linker motif; other site
702113005864	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113005865	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
702113005866	Acyltransferase family; Region: Acyl_transf_3; pfam01757
702113005867	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113005868	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
702113005869	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
702113005870	putative catalytic cysteine [active]
702113005871	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113005872	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113005873	active site
702113005874	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
702113005875	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113005876	substrate binding site [chemical binding]; other site
702113005877	oxyanion hole (OAH) forming residues; other site
702113005878	trimer interface [polypeptide binding]; other site
702113005879	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
702113005880	enoyl-CoA hydratase; Provisional; Region: PRK05862
702113005881	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113005882	substrate binding site [chemical binding]; other site
702113005883	oxyanion hole (OAH) forming residues; other site
702113005884	trimer interface [polypeptide binding]; other site
702113005885	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
702113005886	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
702113005887	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
702113005888	dimer interface [polypeptide binding]; other site
702113005889	ADP-ribose binding site [chemical binding]; other site
702113005890	active site
702113005891	nudix motif; other site
702113005892	metal binding site [ion binding]; metal-binding site
702113005893	Repair protein; Region: Repair_PSII; cl01535
702113005894	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
702113005895	Repair protein; Region: Repair_PSII; pfam04536
702113005896	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
702113005897	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
702113005898	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
702113005899	malate synthase G; Provisional; Region: PRK02999
702113005900	active site
702113005901	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
702113005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113005903	S-adenosylmethionine binding site [chemical binding]; other site
702113005904	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
702113005905	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
702113005906	SurA N-terminal domain; Region: SurA_N; pfam09312
702113005907	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
702113005908	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
702113005909	OstA-like protein; Region: OstA; cl00844
702113005910	Organic solvent tolerance protein; Region: OstA_C; pfam04453
702113005911	multifunctional aminopeptidase A; Provisional; Region: PRK00913
702113005912	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
702113005913	interface (dimer of trimers) [polypeptide binding]; other site
702113005914	Substrate-binding/catalytic site; other site
702113005915	Zn-binding sites [ion binding]; other site
702113005916	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
702113005917	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
702113005918	active site
702113005919	multimer interface [polypeptide binding]; other site
702113005920	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
702113005921	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
702113005922	active site
702113005923	substrate binding site [chemical binding]; other site
702113005924	cosubstrate binding site; other site
702113005925	catalytic site [active]
702113005926	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
702113005927	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
702113005928	dimerization interface [polypeptide binding]; other site
702113005929	putative ATP binding site [chemical binding]; other site
702113005930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
702113005931	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
702113005932	serine O-acetyltransferase; Region: cysE; TIGR01172
702113005933	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
702113005934	trimer interface [polypeptide binding]; other site
702113005935	active site
702113005936	substrate binding site [chemical binding]; other site
702113005937	CoA binding site [chemical binding]; other site
702113005938	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
702113005939	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113005940	(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353
702113005941	NAD binding site [chemical binding]; other site
702113005942	homodimer interface [polypeptide binding]; other site
702113005943	active site
702113005944	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
702113005945	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
702113005946	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
702113005947	putative active site [active]
702113005948	catalytic triad [active]
702113005949	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113005950	PAS domain; Region: PAS_9; pfam13426
702113005951	putative active site [active]
702113005952	heme pocket [chemical binding]; other site
702113005953	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113005954	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113005955	metal binding site [ion binding]; metal-binding site
702113005956	active site
702113005957	I-site; other site
702113005958	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113005959	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
702113005960	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
702113005961	glutaminase active site [active]
702113005962	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
702113005963	dimer interface [polypeptide binding]; other site
702113005964	active site
702113005965	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
702113005966	dimer interface [polypeptide binding]; other site
702113005967	active site
702113005968	Uncharacterized conserved protein [Function unknown]; Region: COG2013
702113005969	Tetratricopeptide repeat; Region: TPR_12; pfam13424
702113005970	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
702113005971	binding surface
702113005972	TPR motif; other site
702113005973	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
702113005974	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
702113005975	Substrate binding site; other site
702113005976	Mg++ binding site; other site
702113005977	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
702113005978	active site
702113005979	substrate binding site [chemical binding]; other site
702113005980	CoA binding site [chemical binding]; other site
702113005981	phosphoglycolate phosphatase; Provisional; Region: PRK13222
702113005982	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113005983	motif II; other site
702113005984	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
702113005985	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
702113005986	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005987	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
702113005988	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
702113005989	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
702113005990	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
702113005991	ATP binding site [chemical binding]; other site
702113005992	active site
702113005993	substrate binding site [chemical binding]; other site
702113005994	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113005995	active site 2 [active]
702113005996	active site 1 [active]
702113005997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
702113005998	Coenzyme A binding pocket [chemical binding]; other site
702113005999	Low molecular weight phosphatase family; Region: LMWPc; cd00115
702113006000	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
702113006001	active site
702113006002	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
702113006003	von Willebrand factor type A domain; Region: VWA_2; pfam13519
702113006004	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113006005	TadE-like protein; Region: TadE; pfam07811
702113006006	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113006007	TadE-like protein; Region: TadE; pfam07811
702113006008	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
702113006009	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113006010	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113006011	DNA binding site [nucleotide binding]
702113006012	domain linker motif; other site
702113006013	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
702113006014	putative dimerization interface [polypeptide binding]; other site
702113006015	putative ligand binding site [chemical binding]; other site
702113006016	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113006017	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113006018	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113006019	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113006020	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
702113006021	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
702113006022	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
702113006023	active site
702113006024	catalytic site [active]
702113006025	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
702113006026	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
702113006027	active site
702113006028	catalytic site [active]
702113006029	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
702113006030	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
702113006031	Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935
702113006032	putative active site [active]
702113006033	putative catalytic site [active]
702113006034	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113006035	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113006036	putative DNA binding site [nucleotide binding]; other site
702113006037	putative Zn2+ binding site [ion binding]; other site
702113006038	AsnC family; Region: AsnC_trans_reg; pfam01037
702113006039	Uncharacterized conserved protein [Function unknown]; Region: COG3791
702113006040	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
702113006041	Dehydroquinase class II; Region: DHquinase_II; pfam01220
702113006042	trimer interface [polypeptide binding]; other site
702113006043	active site
702113006044	dimer interface [polypeptide binding]; other site
702113006045	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
702113006046	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
702113006047	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
702113006048	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
702113006049	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
702113006050	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
702113006051	Protein export membrane protein; Region: SecD_SecF; pfam02355
702113006052	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
702113006053	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113006054	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113006055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113006056	non-specific DNA binding site [nucleotide binding]; other site
702113006057	salt bridge; other site
702113006058	sequence-specific DNA binding site [nucleotide binding]; other site
702113006059	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
702113006060	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113006061	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113006062	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
702113006063	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113006064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113006065	active site
702113006066	phosphorylation site [posttranslational modification]
702113006067	intermolecular recognition site; other site
702113006068	dimerization interface [polypeptide binding]; other site
702113006069	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113006070	DNA binding site [nucleotide binding]
702113006071	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113006072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
702113006073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113006074	ATP binding site [chemical binding]; other site
702113006075	Mg2+ binding site [ion binding]; other site
702113006076	G-X-G motif; other site
702113006077	chorismate mutase; Provisional; Region: PRK09239
702113006078	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
702113006079	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
702113006080	substrate binding pocket [chemical binding]; other site
702113006081	chain length determination region; other site
702113006082	substrate-Mg2+ binding site; other site
702113006083	catalytic residues [active]
702113006084	aspartate-rich region 1; other site
702113006085	active site lid residues [active]
702113006086	aspartate-rich region 2; other site
702113006087	Gram-negative bacterial tonB protein; Region: TonB; cl10048
702113006088	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
702113006089	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113006090	metal binding site [ion binding]; metal-binding site
702113006091	active site
702113006092	I-site; other site
702113006093	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113006094	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
702113006095	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113006096	ATP binding site [chemical binding]; other site
702113006097	putative Mg++ binding site [ion binding]; other site
702113006098	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113006099	nucleotide binding region [chemical binding]; other site
702113006100	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
702113006101	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
702113006102	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
702113006103	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
702113006104	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113006105	Walker A motif; other site
702113006106	ATP binding site [chemical binding]; other site
702113006107	Walker B motif; other site
702113006108	arginine finger; other site
702113006109	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
702113006110	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
702113006111	hypothetical protein; Validated; Region: PRK00153
702113006112	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
702113006113	Found in ATP-dependent protease La (LON); Region: LON; smart00464
702113006114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113006115	Walker A motif; other site
702113006116	ATP binding site [chemical binding]; other site
702113006117	Walker B motif; other site
702113006118	arginine finger; other site
702113006119	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
702113006120	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
702113006121	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113006122	Uncharacterized conserved protein [Function unknown]; Region: COG3791
702113006123	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113006124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113006125	Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461
702113006126	active site
702113006127	Zn binding site [ion binding]; other site
702113006128	AMP nucleosidase; Provisional; Region: PRK08292
702113006129	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
702113006130	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
702113006131	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
702113006132	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
702113006133	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
702113006134	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
702113006135	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
702113006136	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
702113006137	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
702113006138	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113006139	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113006140	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
702113006141	putative N-terminal domain interface [polypeptide binding]; other site
702113006142	putative dimer interface [polypeptide binding]; other site
702113006143	putative substrate binding pocket (H-site) [chemical binding]; other site
702113006144	flagellin; Provisional; Region: PRK12802
702113006145	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
702113006146	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
702113006147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
702113006148	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
702113006149	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
702113006150	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
702113006151	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
702113006152	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
702113006153	dimer interface [polypeptide binding]; other site
702113006154	catalytic triad [active]
702113006155	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113006156	active site
702113006157	metal binding site [ion binding]; metal-binding site
702113006158	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
702113006159	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
702113006160	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
702113006161	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
702113006162	NAD(P) binding site [chemical binding]; other site
702113006163	homotetramer interface [polypeptide binding]; other site
702113006164	homodimer interface [polypeptide binding]; other site
702113006165	active site
702113006166	DNA polymerase III subunit beta; Validated; Region: PRK05643
702113006167	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
702113006168	putative DNA binding surface [nucleotide binding]; other site
702113006169	dimer interface [polypeptide binding]; other site
702113006170	beta-clamp/clamp loader binding surface; other site
702113006171	beta-clamp/translesion DNA polymerase binding surface; other site
702113006172	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
702113006173	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113006174	ferredoxin-NADP+ reductase; Region: PLN02852
702113006175	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113006176	PAS domain; Region: PAS_9; pfam13426
702113006177	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113006178	putative active site [active]
702113006179	heme pocket [chemical binding]; other site
702113006180	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113006181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113006182	metal binding site [ion binding]; metal-binding site
702113006183	active site
702113006184	I-site; other site
702113006185	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113006186	PilZ domain; Region: PilZ; pfam07238
702113006187	GTP-binding protein LepA; Provisional; Region: PRK05433
702113006188	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
702113006189	G1 box; other site
702113006190	putative GEF interaction site [polypeptide binding]; other site
702113006191	GTP/Mg2+ binding site [chemical binding]; other site
702113006192	Switch I region; other site
702113006193	G2 box; other site
702113006194	G3 box; other site
702113006195	Switch II region; other site
702113006196	G4 box; other site
702113006197	G5 box; other site
702113006198	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
702113006199	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
702113006200	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
702113006201	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113006202	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113006203	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113006204	dimerization interface [polypeptide binding]; other site
702113006205	formate dehydrogenase subunit gamma; Validated; Region: PRK05988
702113006206	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081
702113006207	putative dimer interface [polypeptide binding]; other site
702113006208	[2Fe-2S] cluster binding site [ion binding]; other site
702113006209	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063
702113006210	putative dimer interface [polypeptide binding]; other site
702113006211	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
702113006212	SLBB domain; Region: SLBB; pfam10531
702113006213	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
702113006214	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
702113006215	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113006216	catalytic loop [active]
702113006217	iron binding site [ion binding]; other site
702113006218	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
702113006219	4Fe-4S binding domain; Region: Fer4; pfam00037
702113006220	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
702113006221	[4Fe-4S] binding site [ion binding]; other site
702113006222	molybdopterin cofactor binding site; other site
702113006223	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
702113006224	molybdopterin cofactor binding site; other site
702113006225	NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390
702113006226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113006227	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
702113006228	Walker A/P-loop; other site
702113006229	ATP binding site [chemical binding]; other site
702113006230	Q-loop/lid; other site
702113006231	ABC transporter signature motif; other site
702113006232	Walker B; other site
702113006233	D-loop; other site
702113006234	H-loop/switch region; other site
702113006235	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
702113006236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113006237	dimer interface [polypeptide binding]; other site
702113006238	conserved gate region; other site
702113006239	putative PBP binding loops; other site
702113006240	ABC-ATPase subunit interface; other site
702113006241	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
702113006242	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
702113006243	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
702113006244	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113006245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113006246	putative substrate translocation pore; other site
702113006247	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113006248	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
702113006249	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113006250	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113006251	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113006252	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113006253	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
702113006254	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113006255	exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100
702113006256	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113006257	exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101
702113006258	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
702113006259	acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098
702113006260	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113006261	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113006262	acyl-activating enzyme (AAE) consensus motif; other site
702113006263	acyl-activating enzyme (AAE) consensus motif; other site
702113006264	AMP binding site [chemical binding]; other site
702113006265	active site
702113006266	CoA binding site [chemical binding]; other site
702113006267	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
702113006268	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
702113006269	dimer interface [polypeptide binding]; other site
702113006270	active site
702113006271	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113006272	catalytic residues [active]
702113006273	substrate binding site [chemical binding]; other site
702113006274	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
702113006275	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
702113006276	SLBB domain; Region: SLBB; pfam10531
702113006277	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
702113006278	Chain length determinant protein; Region: Wzz; cl15801
702113006279	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
702113006280	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
702113006281	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113006282	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
702113006283	AAA ATPase domain; Region: AAA_16; pfam13191
702113006284	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_2; cd10941
702113006285	polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006
702113006286	putative active site [active]
702113006287	putative catalytic site [active]
702113006288	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
702113006289	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
702113006290	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
702113006291	exosortase A; Region: exosortase_1; TIGR03109
702113006292	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
702113006293	Protein of unknown function (DUF3485); Region: DUF3485; cl11827
702113006294	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
702113006295	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
702113006296	active site
702113006297	dimer interface [polypeptide binding]; other site
702113006298	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
702113006299	Ligand Binding Site [chemical binding]; other site
702113006300	Molecular Tunnel; other site
702113006301	CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080
702113006302	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113006303	Predicted ATPase [General function prediction only]; Region: COG1485
702113006304	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
702113006305	CoenzymeA binding site [chemical binding]; other site
702113006306	subunit interaction site [polypeptide binding]; other site
702113006307	PHB binding site; other site
702113006308	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
702113006309	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
702113006310	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
702113006311	C factor cell-cell signaling protein; Provisional; Region: PRK09009
702113006312	NADP binding site [chemical binding]; other site
702113006313	homodimer interface [polypeptide binding]; other site
702113006314	active site
702113006315	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
702113006316	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
702113006317	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
702113006318	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
702113006319	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
702113006320	active site
702113006321	metal binding site [ion binding]; metal-binding site
702113006322	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
702113006323	Transglycosylase; Region: Transgly; pfam00912
702113006324	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
702113006325	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113006326	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
702113006327	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
702113006328	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
702113006329	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
702113006330	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113006331	catalytic loop [active]
702113006332	iron binding site [ion binding]; other site
702113006333	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
702113006334	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
702113006335	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
702113006336	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113006337	Ubiquitin-like proteins; Region: UBQ; cl00155
702113006338	charged pocket; other site
702113006339	hydrophobic patch; other site
702113006340	elongation factor P; Validated; Region: PRK00529
702113006341	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
702113006342	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
702113006343	RNA binding site [nucleotide binding]; other site
702113006344	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
702113006345	RNA binding site [nucleotide binding]; other site
702113006346	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
702113006347	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
702113006348	active site
702113006349	dimerization interface [polypeptide binding]; other site
702113006350	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
702113006351	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
702113006352	metal binding site [ion binding]; metal-binding site
702113006353	putative dimer interface [polypeptide binding]; other site
702113006354	sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013
702113006355	Bacterial sugar transferase; Region: Bac_transf; pfam02397
702113006356	putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916
702113006357	GAF domain; Region: GAF; pfam01590
702113006358	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113006359	ATP binding site [chemical binding]; other site
702113006360	Mg2+ binding site [ion binding]; other site
702113006361	G-X-G motif; other site
702113006362	PEP-CTERM-box response regulator transcription factor; Region: PEP_resp_reg; TIGR02915
702113006363	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113006364	active site
702113006365	phosphorylation site [posttranslational modification]
702113006366	intermolecular recognition site; other site
702113006367	dimerization interface [polypeptide binding]; other site
702113006368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113006369	Walker A motif; other site
702113006370	ATP binding site [chemical binding]; other site
702113006371	Walker B motif; other site
702113006372	arginine finger; other site
702113006373	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113006374	TPR repeat; Region: TPR_11; pfam13414
702113006375	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113006376	binding surface
702113006377	TPR motif; other site
702113006378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113006379	binding surface
702113006380	TPR motif; other site
702113006381	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
702113006382	oligomerization interface [polypeptide binding]; other site
702113006383	active site
702113006384	metal binding site [ion binding]; metal-binding site
702113006385	amino acid transporter; Region: 2A0306; TIGR00909
702113006386	Uncharacterized conserved protein [Function unknown]; Region: COG4544
702113006387	DNA Polymerase Y-family; Region: PolY_like; cd03468
702113006388	active site
702113006389	Y-family of DNA polymerases; Region: PolY; cl12025
702113006390	DNA binding site [nucleotide binding]
702113006391	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
702113006392	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
702113006393	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
702113006394	putative active site [active]
702113006395	putative PHP Thumb interface [polypeptide binding]; other site
702113006396	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
702113006397	generic binding surface I; other site
702113006398	generic binding surface II; other site
702113006399	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
702113006400	classical (c) SDRs; Region: SDR_c; cd05233
702113006401	NAD(P) binding site [chemical binding]; other site
702113006402	active site
702113006403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113006404	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113006405	SIR2-like domain; Region: SIR2_2; pfam13289
702113006406	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
702113006407	potential protein location (hypothetical protein) that overlaps protein (putative transcriptional regulator)
702113006408	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
702113006409	Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628
702113006410	5' RNA guide strand anchoring site; other site
702113006411	active site
702113006412	CHC2 zinc finger; Region: zf-CHC2; cl17510
702113006413	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
702113006414	active site
702113006415	metal binding site [ion binding]; metal-binding site
702113006416	interdomain interaction site; other site
702113006417	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
702113006418	ParB-like nuclease domain; Region: ParB; smart00470
702113006419	KorB domain; Region: KorB; pfam08535
702113006420	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
702113006421	Helicase_C-like; Region: Helicase_C_4; pfam13871
702113006422	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
702113006423	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
702113006424	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
702113006425	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
702113006426	active site
702113006427	catalytic residues [active]
702113006428	DNA binding site [nucleotide binding]
702113006429	Int/Topo IB signature motif; other site
702113006430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113006431	ATP binding site [chemical binding]; other site
702113006432	Mg2+ binding site [ion binding]; other site
702113006433	G-X-G motif; other site
702113006434	RES domain; Region: RES; cl02411
702113006435	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
702113006436	PemK-like protein; Region: PemK; pfam02452
702113006437	Helix-turn-helix domain; Region: HTH_36; pfam13730
702113006438	Protein of unknown function (DUF736); Region: DUF736; pfam05284
702113006439	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113006440	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113006441	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113006442	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
702113006443	Walker A motif; other site
702113006444	ATP binding site [chemical binding]; other site
702113006445	Walker B motif; other site
702113006446	TrwC relaxase; Region: TrwC; pfam08751
702113006447	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
702113006448	AAA domain; Region: AAA_30; pfam13604
702113006449	Family description; Region: UvrD_C_2; pfam13538
702113006450	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
702113006451	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
702113006452	GAF domain; Region: GAF; pfam01590
702113006453	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113006454	metal binding site [ion binding]; metal-binding site
702113006455	active site
702113006456	I-site; other site
702113006457	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113006458	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113006459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113006460	non-specific DNA binding site [nucleotide binding]; other site
702113006461	salt bridge; other site
702113006462	sequence-specific DNA binding site [nucleotide binding]; other site
702113006463	Bacitracin resistance protein BacA; Region: BacA; pfam02673
702113006464	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
702113006465	Heavy-metal-associated domain; Region: HMA; pfam00403
702113006466	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113006467	Soluble P-type ATPase [General function prediction only]; Region: COG4087
702113006468	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
702113006469	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
702113006470	DNA binding residues [nucleotide binding]
702113006471	dimer interface [polypeptide binding]; other site
702113006472	putative metal binding site [ion binding]; other site
702113006473	Cytochrome c; Region: Cytochrom_C; pfam00034
702113006474	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
702113006475	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113006476	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113006477	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
702113006478	Outer membrane efflux protein; Region: OEP; pfam02321
702113006479	Outer membrane efflux protein; Region: OEP; pfam02321
702113006480	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
702113006481	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113006482	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
702113006483	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
702113006484	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
702113006485	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
702113006486	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113006487	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
702113006488	Cytochrome c; Region: Cytochrom_C; pfam00034
702113006489	Iron permease FTR1 family; Region: FTR1; cl00475
702113006490	Outer membrane efflux protein; Region: OEP; pfam02321
702113006491	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
702113006492	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113006493	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
702113006494	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
702113006495	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
702113006496	Divergent AAA domain; Region: AAA_4; pfam04326
702113006497	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
702113006498	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
702113006499	NAD binding site [chemical binding]; other site
702113006500	substrate binding site [chemical binding]; other site
702113006501	catalytic Zn binding site [ion binding]; other site
702113006502	tetramer interface [polypeptide binding]; other site
702113006503	structural Zn binding site [ion binding]; other site
702113006504	Phosphoglycerate kinase; Region: PGK; pfam00162
702113006505	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
702113006506	substrate binding site [chemical binding]; other site
702113006507	hinge regions; other site
702113006508	ADP binding site [chemical binding]; other site
702113006509	catalytic site [active]
702113006510	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
702113006511	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
702113006512	phosphate binding site [ion binding]; other site
702113006513	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
702113006514	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
702113006515	dimer interface [polypeptide binding]; other site
702113006516	PYR/PP interface [polypeptide binding]; other site
702113006517	TPP binding site [chemical binding]; other site
702113006518	substrate binding site [chemical binding]; other site
702113006519	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113006520	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
702113006521	Domain of unknown function; Region: EKR; pfam10371
702113006522	4Fe-4S binding domain; Region: Fer4_6; pfam12837
702113006523	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
702113006524	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
702113006525	TPP-binding site [chemical binding]; other site
702113006526	dimer interface [polypeptide binding]; other site
702113006527	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
702113006528	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
702113006529	NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493
702113006530	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
702113006531	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
702113006532	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
702113006533	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113006534	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113006535	motif II; other site
702113006536	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
702113006537	potential frameshift: common BLAST hit: gi|292491773|ref|YP_003527212.1| glycosyl transferase group 1
702113006538	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113006539	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
702113006540	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
702113006541	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113006542	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113006543	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
702113006544	ligand binding site [chemical binding]; other site
702113006545	flexible hinge region; other site
702113006546	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
702113006547	putative switch regulator; other site
702113006548	non-specific DNA interactions [nucleotide binding]; other site
702113006549	DNA binding site [nucleotide binding]
702113006550	sequence specific DNA binding site [nucleotide binding]; other site
702113006551	putative cAMP binding site [chemical binding]; other site
702113006552	glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PRK04207
702113006553	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
702113006554	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
702113006555	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
702113006556	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
702113006557	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
702113006558	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113006559	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113006560	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
702113006561	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113006562	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
702113006563	Int/Topo IB signature motif; other site
702113006564	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113006565	active site
702113006566	DNA binding site [nucleotide binding]
702113006567	Int/Topo IB signature motif; other site
702113006568	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
702113006569	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
702113006570	Int/Topo IB signature motif; other site
702113006571	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113006572	Transposase; Region: DEDD_Tnp_IS110; pfam01548
702113006573	Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396
702113006574	Cytochrome c; Region: Cytochrom_C; pfam00034
702113006575	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
702113006576	potential frameshift: common BLAST hit: gi|103488033|ref|YP_617594.1| vitamin K epoxide reductase
702113006577	Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919
702113006578	putative active site [active]
702113006579	redox center [active]
702113006580	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113006581	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113006582	NAD(P) binding site [chemical binding]; other site
702113006583	active site
702113006584	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
702113006585	Transposase, Mutator family; Region: Transposase_mut; pfam00872
702113006586	MULE transposase domain; Region: MULE; pfam10551
702113006587	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
702113006588	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
702113006589	Ligand Binding Site [chemical binding]; other site
702113006590	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
702113006591	Ligand Binding Site [chemical binding]; other site
702113006592	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
702113006593	Putative glucoamylase; Region: Glycoamylase; pfam10091
702113006594	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
702113006595	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
702113006596	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
702113006597	Ion channel; Region: Ion_trans_2; pfam07885
702113006598	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
702113006599	ABC1 family; Region: ABC1; cl17513
702113006600	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
702113006601	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113006602	S-adenosylmethionine binding site [chemical binding]; other site
702113006603	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113006604	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
702113006605	phosphoenolpyruvate synthase; Validated; Region: PRK06464
702113006606	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
702113006607	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
702113006608	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113006609	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
702113006610	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
702113006611	putative acyl-acceptor binding pocket; other site
702113006612	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
702113006613	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
702113006614	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
702113006615	putative active site [active]
702113006616	catalytic site [active]
702113006617	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
702113006618	putative active site [active]
702113006619	catalytic site [active]
702113006620	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
702113006621	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
702113006622	EamA-like transporter family; Region: EamA; pfam00892
702113006623	EamA-like transporter family; Region: EamA; pfam00892
702113006624	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
702113006625	propionate/acetate kinase; Provisional; Region: PRK12379
702113006626	Acetokinase family; Region: Acetate_kinase; cl17229
702113006627	Protein of unknown function (DUF3141); Region: DUF3141; pfam11339
702113006628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
702113006629	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
702113006630	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113006631	Soluble P-type ATPase [General function prediction only]; Region: COG4087
702113006632	phosphoglucomutase; Validated; Region: PRK07564
702113006633	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
702113006634	active site
702113006635	substrate binding site [chemical binding]; other site
702113006636	metal binding site [ion binding]; metal-binding site
702113006637	Predicted membrane protein [Function unknown]; Region: COG3174
702113006638	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
702113006639	FtsH Extracellular; Region: FtsH_ext; pfam06480
702113006640	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
702113006641	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113006642	Walker A motif; other site
702113006643	ATP binding site [chemical binding]; other site
702113006644	Walker B motif; other site
702113006645	arginine finger; other site
702113006646	Peptidase family M41; Region: Peptidase_M41; pfam01434
702113006647	myosin-cross-reactive antigen; Provisional; Region: PRK13977
702113006648	FtsH Extracellular; Region: FtsH_ext; pfam06480
702113006649	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
702113006650	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113006651	Walker A motif; other site
702113006652	ATP binding site [chemical binding]; other site
702113006653	Walker B motif; other site
702113006654	arginine finger; other site
702113006655	Peptidase family M41; Region: Peptidase_M41; pfam01434
702113006656	YHS domain; Region: YHS; pfam04945
702113006657	LTXXQ motif family protein; Region: LTXXQ; pfam07813
702113006658	potential frameshift: common BLAST hit: gi|319790050|ref|YP_004151683.1| Methionine adenosyltransferase
702113006659	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
702113006660	S-adenosylmethionine synthetase; Provisional; Region: PRK04439
702113006661	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
702113006662	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113006663	ligand binding site [chemical binding]; other site
702113006664	flexible hinge region; other site
702113006665	phosphopeptide binding site; other site
702113006666	FHA domain; Region: FHA; pfam00498
702113006667	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113006668	active site
702113006669	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113006670	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
702113006671	catalytic residues [active]
702113006672	catalytic nucleophile [active]
702113006673	Recombinase; Region: Recombinase; pfam07508
702113006674	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
702113006675	Helix-turn-helix domain; Region: HTH_17; pfam12728
702113006676	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
702113006677	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
702113006678	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
702113006679	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
702113006680	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
702113006681	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
702113006682	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
702113006683	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113006684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
702113006685	active site
702113006686	phosphorylation site [posttranslational modification]
702113006687	intermolecular recognition site; other site
702113006688	dimerization interface [polypeptide binding]; other site
702113006689	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
702113006690	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113006691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113006692	motif II; other site
702113006693	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
702113006694	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
702113006695	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113006696	active site
702113006697	thymidine phosphorylase; Provisional; Region: PRK04350
702113006698	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
702113006699	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
702113006700	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
702113006701	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113006702	Beta-Casp domain; Region: Beta-Casp; smart01027
702113006703	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
702113006704	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
702113006705	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
702113006706	putative substrate binding site [chemical binding]; other site
702113006707	putative ATP binding site [chemical binding]; other site
702113006708	YHS domain; Region: YHS; pfam04945
702113006709	Repair protein; Region: Repair_PSII; cl01535
702113006710	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
702113006711	Repair protein; Region: Repair_PSII; pfam04536
702113006712	LemA family; Region: LemA; cl00742
702113006713	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113006714	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113006715	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113006716	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113006717	active site
702113006718	phosphorylation site [posttranslational modification]
702113006719	intermolecular recognition site; other site
702113006720	dimerization interface [polypeptide binding]; other site
702113006721	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
702113006722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113006723	active site
702113006724	phosphorylation site [posttranslational modification]
702113006725	intermolecular recognition site; other site
702113006726	dimerization interface [polypeptide binding]; other site
702113006727	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113006728	DNA binding residues [nucleotide binding]
702113006729	dimerization interface [polypeptide binding]; other site
702113006730	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113006731	PAS domain; Region: PAS_9; pfam13426
702113006732	putative active site [active]
702113006733	heme pocket [chemical binding]; other site
702113006734	PAS domain S-box; Region: sensory_box; TIGR00229
702113006735	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113006736	putative active site [active]
702113006737	heme pocket [chemical binding]; other site
702113006738	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113006739	dimer interface [polypeptide binding]; other site
702113006740	phosphorylation site [posttranslational modification]
702113006741	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113006742	ATP binding site [chemical binding]; other site
702113006743	Mg2+ binding site [ion binding]; other site
702113006744	G-X-G motif; other site
702113006745	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
702113006746	Ligand Binding Site [chemical binding]; other site
702113006747	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
702113006748	D-Lactate and related Dehydrogenase like proteins, NAD-binding and catalytic domains; Region: LDH_like_1; cd12187
702113006749	ligand binding site [chemical binding]; other site
702113006750	NAD binding site [chemical binding]; other site
702113006751	homodimer interface [polypeptide binding]; other site
702113006752	catalytic site [active]
702113006753	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113006754	Copper resistance protein D; Region: CopD; cl00563
702113006755	CopC domain; Region: CopC; pfam04234
702113006756	Protein of unknown function, DUF; Region: DUF411; cl01142
702113006757	Methyltransferase domain; Region: Methyltransf_31; pfam13847
702113006758	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113006759	S-adenosylmethionine binding site [chemical binding]; other site
702113006760	Heavy-metal resistance; Region: Metal_resist; pfam13801
702113006761	dimer interface [polypeptide binding]; other site
702113006762	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113006763	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113006764	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113006765	DNA binding residues [nucleotide binding]
702113006766	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
702113006767	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
702113006768	Multicopper oxidase; Region: Cu-oxidase; pfam00394
702113006769	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
702113006770	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
702113006771	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
702113006772	Ion channel; Region: Ion_trans_2; pfam07885
702113006773	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
702113006774	Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122
702113006775	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
702113006776	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
702113006777	putative active site [active]
702113006778	F plasmid transfer operon protein; Region: TraF; pfam13728
702113006779	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
702113006780	catalytic residues [active]
702113006781	Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959
702113006782	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
702113006783	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673
702113006784	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
702113006785	conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14876
702113006786	TraU protein; Region: TraU; pfam06834
702113006787	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
702113006788	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
702113006789	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
702113006790	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
702113006791	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113006792	TraK protein; Region: TraK; pfam06586
702113006793	TraE protein; Region: TraE; cl05060
702113006794	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
702113006795	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
702113006796	dimerization domain [polypeptide binding]; other site
702113006797	dimer interface [polypeptide binding]; other site
702113006798	catalytic residues [active]
702113006799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113006800	non-specific DNA binding site [nucleotide binding]; other site
702113006801	salt bridge; other site
702113006802	sequence-specific DNA binding site [nucleotide binding]; other site
702113006803	MarR family; Region: MarR_2; cl17246
702113006804	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
702113006805	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
702113006806	IHF dimer interface [polypeptide binding]; other site
702113006807	IHF - DNA interface [nucleotide binding]; other site
702113006808	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
702113006809	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
702113006810	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113006811	active site
702113006812	DNA binding site [nucleotide binding]
702113006813	Int/Topo IB signature motif; other site
702113006814	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
702113006815	DHH family; Region: DHH; pfam01368
702113006816	DHHA1 domain; Region: DHHA1; pfam02272
702113006817	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
702113006818	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
702113006819	FMN binding site [chemical binding]; other site
702113006820	substrate binding site [chemical binding]; other site
702113006821	putative catalytic residue [active]
702113006822	2-isopropylmalate synthase; Validated; Region: PRK03739
702113006823	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
702113006824	active site
702113006825	catalytic residues [active]
702113006826	metal binding site [ion binding]; metal-binding site
702113006827	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
702113006828	Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720
702113006829	YceI-like domain; Region: YceI; smart00867
702113006830	ketol-acid reductoisomerase; Provisional; Region: PRK05479
702113006831	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
702113006832	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
702113006833	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
702113006834	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
702113006835	putative valine binding site [chemical binding]; other site
702113006836	dimer interface [polypeptide binding]; other site
702113006837	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
702113006838	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
702113006839	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
702113006840	PYR/PP interface [polypeptide binding]; other site
702113006841	dimer interface [polypeptide binding]; other site
702113006842	TPP binding site [chemical binding]; other site
702113006843	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
702113006844	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
702113006845	TPP-binding site [chemical binding]; other site
702113006846	dimer interface [polypeptide binding]; other site
702113006847	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
702113006848	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
702113006849	phosphoserine phosphatase SerB; Region: serB; TIGR00338
702113006850	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
702113006851	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113006852	motif II; other site
702113006853	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
702113006854	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
702113006855	dimerization interface [polypeptide binding]; other site
702113006856	ATP binding site [chemical binding]; other site
702113006857	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
702113006858	dimerization interface [polypeptide binding]; other site
702113006859	ATP binding site [chemical binding]; other site
702113006860	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
702113006861	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
702113006862	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
702113006863	substrate binding pocket [chemical binding]; other site
702113006864	chain length determination region; other site
702113006865	substrate-Mg2+ binding site; other site
702113006866	catalytic residues [active]
702113006867	aspartate-rich region 1; other site
702113006868	active site lid residues [active]
702113006869	aspartate-rich region 2; other site
702113006870	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
702113006871	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
702113006872	active site
702113006873	(T/H)XGH motif; other site
702113006874	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
702113006875	active site
702113006876	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
702113006877	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
702113006878	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
702113006879	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
702113006880	Walker A/P-loop; other site
702113006881	ATP binding site [chemical binding]; other site
702113006882	Q-loop/lid; other site
702113006883	ABC transporter signature motif; other site
702113006884	Walker B; other site
702113006885	D-loop; other site
702113006886	H-loop/switch region; other site
702113006887	ABC-2 type transporter; Region: ABC2_membrane; cl17235
702113006888	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
702113006889	Protein of unknown function, DUF481; Region: DUF481; pfam04338
702113006890	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
702113006891	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
702113006892	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113006893	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113006894	P-loop; other site
702113006895	Magnesium ion binding site [ion binding]; other site
702113006896	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
702113006897	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
702113006898	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
702113006899	RNA binding surface [nucleotide binding]; other site
702113006900	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
702113006901	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
702113006902	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
702113006903	ATP cone domain; Region: ATP-cone; pfam03477
702113006904	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
702113006905	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
702113006906	dimer interface [polypeptide binding]; other site
702113006907	active site
702113006908	glycine-pyridoxal phosphate binding site [chemical binding]; other site
702113006909	folate binding site [chemical binding]; other site
702113006910	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
702113006911	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
702113006912	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
702113006913	tetramer interface [polypeptide binding]; other site
702113006914	heme binding pocket [chemical binding]; other site
702113006915	NADPH binding site [chemical binding]; other site
702113006916	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
702113006917	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
702113006918	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
702113006919	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
702113006920	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113006921	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
702113006922	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113006923	DNA binding residues [nucleotide binding]
702113006924	DNA primase; Validated; Region: dnaG; PRK05667
702113006925	CHC2 zinc finger; Region: zf-CHC2; pfam01807
702113006926	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
702113006927	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
702113006928	active site
702113006929	metal binding site [ion binding]; metal-binding site
702113006930	interdomain interaction site; other site
702113006931	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
702113006932	Yqey-like protein; Region: YqeY; pfam09424
702113006933	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
702113006934	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
702113006935	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
702113006936	catalytic site [active]
702113006937	subunit interface [polypeptide binding]; other site
702113006938	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
702113006939	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113006940	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
702113006941	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
702113006942	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113006943	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113006944	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
702113006945	IMP binding site; other site
702113006946	dimer interface [polypeptide binding]; other site
702113006947	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
702113006948	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
702113006949	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
702113006950	Domain of unknown function (DUF4170); Region: DUF4170; pfam13773
702113006951	enolase; Provisional; Region: eno; PRK00077
702113006952	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
702113006953	dimer interface [polypeptide binding]; other site
702113006954	metal binding site [ion binding]; metal-binding site
702113006955	substrate binding pocket [chemical binding]; other site
702113006956	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113006957	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
702113006958	homopentamer interface [polypeptide binding]; other site
702113006959	active site
702113006960	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
702113006961	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
702113006962	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
702113006963	dimerization interface [polypeptide binding]; other site
702113006964	active site
702113006965	MEKHLA domain; Region: MEKHLA; pfam08670
702113006966	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
702113006967	active site
702113006968	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
702113006969	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
702113006970	Surface antigen; Region: Bac_surface_Ag; pfam01103
702113006971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
702113006972	Family of unknown function (DUF490); Region: DUF490; pfam04357
702113006973	PilZ domain; Region: PilZ; pfam07238
702113006974	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
702113006975	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
702113006976	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
702113006977	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
702113006978	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
702113006979	rod shape-determining protein MreC; Provisional; Region: PRK13922
702113006980	rod shape-determining protein MreC; Region: MreC; pfam04085
702113006981	rod shape-determining protein MreB; Provisional; Region: PRK13927
702113006982	MreB and similar proteins; Region: MreB_like; cd10225
702113006983	nucleotide binding site [chemical binding]; other site
702113006984	Mg binding site [ion binding]; other site
702113006985	putative protofilament interaction site [polypeptide binding]; other site
702113006986	RodZ interaction site [polypeptide binding]; other site
702113006987	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
702113006988	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113006989	ATP binding site [chemical binding]; other site
702113006990	Mg2+ binding site [ion binding]; other site
702113006991	G-X-G motif; other site
702113006992	DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119
702113006993	ATP binding site [chemical binding]; other site
702113006994	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
702113006995	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113006996	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
702113006997	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
702113006998	GTP-binding protein YchF; Reviewed; Region: PRK09601
702113006999	YchF GTPase; Region: YchF; cd01900
702113007000	G1 box; other site
702113007001	GTP/Mg2+ binding site [chemical binding]; other site
702113007002	Switch I region; other site
702113007003	G2 box; other site
702113007004	Switch II region; other site
702113007005	G3 box; other site
702113007006	G4 box; other site
702113007007	G5 box; other site
702113007008	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
702113007009	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
702113007010	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
702113007011	putative active site [active]
702113007012	catalytic residue [active]
702113007013	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
702113007014	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
702113007015	5S rRNA interface [nucleotide binding]; other site
702113007016	CTC domain interface [polypeptide binding]; other site
702113007017	L16 interface [polypeptide binding]; other site
702113007018	TraB family; Region: TraB; pfam01963
702113007019	TraB family; Region: TraB; pfam01963
702113007020	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
702113007021	dimer interface [polypeptide binding]; other site
702113007022	motif 1; other site
702113007023	active site
702113007024	motif 2; other site
702113007025	motif 3; other site
702113007026	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
702113007027	pyruvate phosphate dikinase; Provisional; Region: PRK09279
702113007028	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
702113007029	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
702113007030	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113007031	Methyltransferase domain; Region: Methyltransf_23; pfam13489
702113007032	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113007033	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
702113007034	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
702113007035	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
702113007036	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
702113007037	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
702113007038	dimer interface [polypeptide binding]; other site
702113007039	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113007040	catalytic residue [active]
702113007041	H+ Antiporter protein; Region: 2A0121; TIGR00900
702113007042	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113007043	putative substrate translocation pore; other site
702113007044	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
702113007045	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113007046	PilZ domain; Region: PilZ; cl01260
702113007047	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
702113007048	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
702113007049	active site
702113007050	HIGH motif; other site
702113007051	dimer interface [polypeptide binding]; other site
702113007052	KMSKS motif; other site
702113007053	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
702113007054	putative heme binding site [chemical binding]; other site
702113007055	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
702113007056	SnoaL-like domain; Region: SnoaL_3; pfam13474
702113007057	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
702113007058	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
702113007059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
702113007060	Uncharacterized conserved protein [Function unknown]; Region: COG3791
702113007061	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
702113007062	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113007063	Walker A motif; other site
702113007064	ATP binding site [chemical binding]; other site
702113007065	Walker B motif; other site
702113007066	arginine finger; other site
702113007067	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
702113007068	Uncharacterized conserved protein [Function unknown]; Region: COG1432
702113007069	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
702113007070	putative metal binding site [ion binding]; other site
702113007071	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
702113007072	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
702113007073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007074	ATP binding site [chemical binding]; other site
702113007075	Mg2+ binding site [ion binding]; other site
702113007076	G-X-G motif; other site
702113007077	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
702113007078	anchoring element; other site
702113007079	dimer interface [polypeptide binding]; other site
702113007080	ATP binding site [chemical binding]; other site
702113007081	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
702113007082	active site
702113007083	metal binding site [ion binding]; metal-binding site
702113007084	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
702113007085	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
702113007086	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
702113007087	putative ligand binding site [chemical binding]; other site
702113007088	Predicted methyltransferases [General function prediction only]; Region: COG0313
702113007089	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
702113007090	putative SAM binding site [chemical binding]; other site
702113007091	putative homodimer interface [polypeptide binding]; other site
702113007092	glutathione synthetase; Provisional; Region: PRK05246
702113007093	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
702113007094	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
702113007095	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113007096	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113007097	active site
702113007098	DNA binding site [nucleotide binding]
702113007099	Int/Topo IB signature motif; other site
702113007100	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
702113007101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113007102	FeS/SAM binding site; other site
702113007103	HemN C-terminal domain; Region: HemN_C; pfam06969
702113007104	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
702113007105	active site
702113007106	dimerization interface [polypeptide binding]; other site
702113007107	ribonuclease PH; Reviewed; Region: rph; PRK00173
702113007108	Ribonuclease PH; Region: RNase_PH_bact; cd11362
702113007109	hexamer interface [polypeptide binding]; other site
702113007110	active site
702113007111	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
702113007112	GrpE; Region: GrpE; pfam01025
702113007113	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
702113007114	dimer interface [polypeptide binding]; other site
702113007115	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
702113007116	Protein of unknown function (DUF461); Region: DUF461; pfam04314
702113007117	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
702113007118	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
702113007119	nucleotide binding site [chemical binding]; other site
702113007120	NEF interaction site [polypeptide binding]; other site
702113007121	SBD interface [polypeptide binding]; other site
702113007122	chaperone protein DnaJ; Provisional; Region: PRK10767
702113007123	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
702113007124	HSP70 interaction site [polypeptide binding]; other site
702113007125	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
702113007126	substrate binding site [polypeptide binding]; other site
702113007127	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
702113007128	Zn binding sites [ion binding]; other site
702113007129	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
702113007130	dimer interface [polypeptide binding]; other site
702113007131	patatin-related protein; Region: TIGR03607
702113007132	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
702113007133	DNA repair protein RadA; Provisional; Region: PRK11823
702113007134	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
702113007135	Walker A motif/ATP binding site; other site
702113007136	ATP binding site [chemical binding]; other site
702113007137	Walker B motif; other site
702113007138	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
702113007139	Colicin V production protein; Region: Colicin_V; pfam02674
702113007140	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
702113007141	trimerization site [polypeptide binding]; other site
702113007142	active site
702113007143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113007144	putative substrate translocation pore; other site
702113007145	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
702113007146	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
702113007147	active site
702113007148	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113007149	dimer interface [polypeptide binding]; other site
702113007150	substrate binding site [chemical binding]; other site
702113007151	catalytic residues [active]
702113007152	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394
702113007153	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
702113007154	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
702113007155	prolyl-tRNA synthetase; Provisional; Region: PRK08661
702113007156	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
702113007157	dimer interface [polypeptide binding]; other site
702113007158	motif 1; other site
702113007159	active site
702113007160	motif 2; other site
702113007161	motif 3; other site
702113007162	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
702113007163	anticodon binding site; other site
702113007164	Protein of unknown function (DUF805); Region: DUF805; pfam05656
702113007165	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
702113007166	Peptidase family M28; Region: Peptidase_M28; pfam04389
702113007167	putative metal binding site [ion binding]; other site
702113007168	ribonuclease R; Region: RNase_R; TIGR02063
702113007169	RNB domain; Region: RNB; pfam00773
702113007170	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
702113007171	RNA binding site [nucleotide binding]; other site
702113007172	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
702113007173	Ligand Binding Site [chemical binding]; other site
702113007174	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
702113007175	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113007176	E3 interaction surface; other site
702113007177	lipoyl attachment site [posttranslational modification]; other site
702113007178	e3 binding domain; Region: E3_binding; pfam02817
702113007179	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
702113007180	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
702113007181	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
702113007182	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113007183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113007184	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
702113007185	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
702113007186	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113007187	acyl-activating enzyme (AAE) consensus motif; other site
702113007188	AMP binding site [chemical binding]; other site
702113007189	active site
702113007190	CoA binding site [chemical binding]; other site
702113007191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113007192	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
702113007193	Coenzyme A binding pocket [chemical binding]; other site
702113007194	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113007195	putative substrate translocation pore; other site
702113007196	Porin subfamily; Region: Porin_2; pfam02530
702113007197	acetyl-CoA synthetase; Provisional; Region: PRK00174
702113007198	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
702113007199	active site
702113007200	CoA binding site [chemical binding]; other site
702113007201	acyl-activating enzyme (AAE) consensus motif; other site
702113007202	AMP binding site [chemical binding]; other site
702113007203	acetate binding site [chemical binding]; other site
702113007204	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113007205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
702113007206	active site
702113007207	phosphorylation site [posttranslational modification]
702113007208	intermolecular recognition site; other site
702113007209	dimerization interface [polypeptide binding]; other site
702113007210	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113007211	DNA binding residues [nucleotide binding]
702113007212	dimerization interface [polypeptide binding]; other site
702113007213	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
702113007214	Na binding site [ion binding]; other site
702113007215	PAS fold; Region: PAS_7; pfam12860
702113007216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113007217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113007218	dimer interface [polypeptide binding]; other site
702113007219	phosphorylation site [posttranslational modification]
702113007220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007221	ATP binding site [chemical binding]; other site
702113007222	Mg2+ binding site [ion binding]; other site
702113007223	G-X-G motif; other site
702113007224	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113007225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113007226	active site
702113007227	phosphorylation site [posttranslational modification]
702113007228	intermolecular recognition site; other site
702113007229	dimerization interface [polypeptide binding]; other site
702113007230	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
702113007231	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
702113007232	protein binding site [polypeptide binding]; other site
702113007233	integrase; Provisional; Region: PRK09692
702113007234	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
702113007235	active site
702113007236	Int/Topo IB signature motif; other site
702113007237	Transglycosylase SLT domain; Region: SLT_2; pfam13406
702113007238	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113007239	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113007240	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
702113007241	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
702113007242	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
702113007243	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
702113007244	thymidylate kinase; Validated; Region: tmk; PRK00698
702113007245	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
702113007246	TMP-binding site; other site
702113007247	ATP-binding site [chemical binding]; other site
702113007248	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
702113007249	DNA polymerase III subunit delta'; Validated; Region: PRK08485
702113007250	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
702113007251	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
702113007252	active site
702113007253	HIGH motif; other site
702113007254	KMSKS motif; other site
702113007255	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
702113007256	tRNA binding surface [nucleotide binding]; other site
702113007257	anticodon binding site; other site
702113007258	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
702113007259	active site
702113007260	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
702113007261	putative hydrolase; Provisional; Region: PRK02113
702113007262	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
702113007263	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
702113007264	homodimer interface [polypeptide binding]; other site
702113007265	metal binding site [ion binding]; metal-binding site
702113007266	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
702113007267	homodimer interface [polypeptide binding]; other site
702113007268	active site
702113007269	putative chemical substrate binding site [chemical binding]; other site
702113007270	metal binding site [ion binding]; metal-binding site
702113007271	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
702113007272	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
702113007273	HflX GTPase family; Region: HflX; cd01878
702113007274	G1 box; other site
702113007275	GTP/Mg2+ binding site [chemical binding]; other site
702113007276	Switch I region; other site
702113007277	G2 box; other site
702113007278	G3 box; other site
702113007279	Switch II region; other site
702113007280	G4 box; other site
702113007281	G5 box; other site
702113007282	RNA-binding protein Hfq; Provisional; Region: PRK14091
702113007283	bacterial Hfq-like; Region: Hfq; cd01716
702113007284	hexamer interface [polypeptide binding]; other site
702113007285	Sm1 motif; other site
702113007286	RNA binding site [nucleotide binding]; other site
702113007287	Sm2 motif; other site
702113007288	bacterial Hfq-like; Region: Hfq; cd01716
702113007289	hexamer interface [polypeptide binding]; other site
702113007290	Sm1 motif; other site
702113007291	RNA binding site [nucleotide binding]; other site
702113007292	Sm2 motif; other site
702113007293	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
702113007294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113007295	active site
702113007296	phosphorylation site [posttranslational modification]
702113007297	intermolecular recognition site; other site
702113007298	dimerization interface [polypeptide binding]; other site
702113007299	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113007300	Walker A motif; other site
702113007301	ATP binding site [chemical binding]; other site
702113007302	Walker B motif; other site
702113007303	arginine finger; other site
702113007304	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113007305	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
702113007306	dimerization interface [polypeptide binding]; other site
702113007307	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113007308	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113007309	dimer interface [polypeptide binding]; other site
702113007310	phosphorylation site [posttranslational modification]
702113007311	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007312	ATP binding site [chemical binding]; other site
702113007313	Mg2+ binding site [ion binding]; other site
702113007314	G-X-G motif; other site
702113007315	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
702113007316	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113007317	active site
702113007318	phosphorylation site [posttranslational modification]
702113007319	intermolecular recognition site; other site
702113007320	dimerization interface [polypeptide binding]; other site
702113007321	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113007322	Walker A motif; other site
702113007323	ATP binding site [chemical binding]; other site
702113007324	Walker B motif; other site
702113007325	arginine finger; other site
702113007326	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
702113007327	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
702113007328	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113007329	putative active site [active]
702113007330	heme pocket [chemical binding]; other site
702113007331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113007332	dimer interface [polypeptide binding]; other site
702113007333	phosphorylation site [posttranslational modification]
702113007334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007335	ATP binding site [chemical binding]; other site
702113007336	Mg2+ binding site [ion binding]; other site
702113007337	G-X-G motif; other site
702113007338	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
702113007339	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
702113007340	FMN binding site [chemical binding]; other site
702113007341	active site
702113007342	catalytic residues [active]
702113007343	substrate binding site [chemical binding]; other site
702113007344	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
702113007345	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
702113007346	substrate binding site; other site
702113007347	dimer interface; other site
702113007348	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
702113007349	homotrimer interaction site [polypeptide binding]; other site
702113007350	zinc binding site [ion binding]; other site
702113007351	CDP-binding sites; other site
702113007352	Competence-damaged protein; Region: CinA; pfam02464
702113007353	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
702113007354	putative coenzyme Q binding site [chemical binding]; other site
702113007355	lipoyl synthase; Provisional; Region: PRK05481
702113007356	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113007357	FeS/SAM binding site; other site
702113007358	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
702113007359	active site clefts [active]
702113007360	zinc binding site [ion binding]; other site
702113007361	dimer interface [polypeptide binding]; other site
702113007362	DNA gyrase subunit A; Validated; Region: PRK05560
702113007363	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
702113007364	CAP-like domain; other site
702113007365	active site
702113007366	primary dimer interface [polypeptide binding]; other site
702113007367	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
702113007368	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
702113007369	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
702113007370	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
702113007371	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
702113007372	Protein of unknown function (DUF952); Region: DUF952; pfam06108
702113007373	YhhN-like protein; Region: YhhN; cl01505
702113007374	Glucose inhibited division protein A; Region: GIDA; pfam01134
702113007375	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
702113007376	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007377	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
702113007378	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007379	TadE-like protein; Region: TadE; pfam07811
702113007380	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
702113007381	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113007382	E3 interaction surface; other site
702113007383	lipoyl attachment site [posttranslational modification]; other site
702113007384	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
702113007385	alpha subunit interface [polypeptide binding]; other site
702113007386	TPP binding site [chemical binding]; other site
702113007387	heterodimer interface [polypeptide binding]; other site
702113007388	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113007389	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
702113007390	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
702113007391	tetramer interface [polypeptide binding]; other site
702113007392	TPP-binding site [chemical binding]; other site
702113007393	heterodimer interface [polypeptide binding]; other site
702113007394	phosphorylation loop region [posttranslational modification]
702113007395	Septum formation initiator; Region: DivIC; cl17659
702113007396	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
702113007397	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
702113007398	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
702113007399	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
702113007400	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
702113007401	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
702113007402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113007403	Walker A/P-loop; other site
702113007404	ATP binding site [chemical binding]; other site
702113007405	Q-loop/lid; other site
702113007406	ABC transporter signature motif; other site
702113007407	Walker B; other site
702113007408	D-loop; other site
702113007409	H-loop/switch region; other site
702113007410	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
702113007411	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
702113007412	Walker A/P-loop; other site
702113007413	ATP binding site [chemical binding]; other site
702113007414	Q-loop/lid; other site
702113007415	ABC transporter signature motif; other site
702113007416	Walker B; other site
702113007417	D-loop; other site
702113007418	H-loop/switch region; other site
702113007419	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
702113007420	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113007421	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113007422	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113007423	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113007424	Domain of unknown function (DUF1956); Region: DUF1956; pfam09209
702113007425	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
702113007426	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113007427	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113007428	ABC transporter; Region: ABC_tran_2; pfam12848
702113007429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113007430	transcription elongation factor regulatory protein; Validated; Region: PRK06342
702113007431	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
702113007432	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
702113007433	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
702113007434	ATP binding site [chemical binding]; other site
702113007435	Mg++ binding site [ion binding]; other site
702113007436	motif III; other site
702113007437	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113007438	nucleotide binding region [chemical binding]; other site
702113007439	ATP-binding site [chemical binding]; other site
702113007440	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
702113007441	RNA binding site [nucleotide binding]; other site
702113007442	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
702113007443	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
702113007444	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113007445	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113007446	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
702113007447	Fusaric acid resistance protein family; Region: FUSC; pfam04632
702113007448	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
702113007449	transcriptional regulator SlyA; Provisional; Region: PRK03573
702113007450	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
702113007451	homotrimer interface [polypeptide binding]; other site
702113007452	Walker A motif; other site
702113007453	GTP binding site [chemical binding]; other site
702113007454	Walker B motif; other site
702113007455	cobyric acid synthase; Provisional; Region: PRK00784
702113007456	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113007457	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
702113007458	catalytic triad [active]
702113007459	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
702113007460	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113007461	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
702113007462	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007463	catalytic residue [active]
702113007464	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
702113007465	catalytic core [active]
702113007466	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
702113007467	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
702113007468	putative dimer interface [polypeptide binding]; other site
702113007469	active site pocket [active]
702113007470	putative cataytic base [active]
702113007471	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
702113007472	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
702113007473	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
702113007474	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
702113007475	homodimer interface [polypeptide binding]; other site
702113007476	Walker A motif; other site
702113007477	ATP binding site [chemical binding]; other site
702113007478	hydroxycobalamin binding site [chemical binding]; other site
702113007479	Walker B motif; other site
702113007480	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
702113007481	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
702113007482	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113007483	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113007484	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
702113007485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113007486	TPR motif; other site
702113007487	TPR repeat; Region: TPR_11; pfam13414
702113007488	binding surface
702113007489	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
702113007490	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
702113007491	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
702113007492	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
702113007493	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
702113007494	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
702113007495	ATP binding site [chemical binding]; other site
702113007496	Walker A motif; other site
702113007497	hexamer interface [polypeptide binding]; other site
702113007498	Walker B motif; other site
702113007499	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
702113007500	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113007501	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007502	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007503	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
702113007504	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
702113007505	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
702113007506	BON domain; Region: BON; pfam04972
702113007507	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
702113007508	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
702113007509	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
702113007510	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
702113007511	Protein of unknown function (DUF2029); Region: DUF2029; pfam09594
702113007512	Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596
702113007513	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
702113007514	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113007515	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113007516	Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773
702113007517	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
702113007518	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
702113007519	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
702113007520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113007521	Walker A/P-loop; other site
702113007522	ATP binding site [chemical binding]; other site
702113007523	Q-loop/lid; other site
702113007524	ABC transporter signature motif; other site
702113007525	Walker B; other site
702113007526	D-loop; other site
702113007527	H-loop/switch region; other site
702113007528	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
702113007529	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
702113007530	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113007531	ligand binding site [chemical binding]; other site
702113007532	potential frameshift: common BLAST hit: gi|319781735|ref|YP_004141211.1| outer membrane adhesin like proteiin
702113007533	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
702113007534	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
702113007535	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
702113007536	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
702113007537	DXD motif; other site
702113007538	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
702113007539	heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914
702113007540	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
702113007541	lipoyl-biotinyl attachment site [posttranslational modification]; other site
702113007542	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113007543	Outer membrane efflux protein; Region: OEP; pfam02321
702113007544	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
702113007545	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113007546	Predicted oxidoreductase [General function prediction only]; Region: COG3573
702113007547	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007548	TadE-like protein; Region: TadE; pfam07811
702113007549	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113007550	TadE-like protein; Region: TadE; pfam07811
702113007551	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
702113007552	nitrilase; Region: PLN02798
702113007553	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
702113007554	putative active site [active]
702113007555	catalytic triad [active]
702113007556	dimer interface [polypeptide binding]; other site
702113007557	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
702113007558	GSH binding site [chemical binding]; other site
702113007559	catalytic residues [active]
702113007560	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
702113007561	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
702113007562	putative dimer interface [polypeptide binding]; other site
702113007563	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
702113007564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
702113007565	dimerization interface [polypeptide binding]; other site
702113007566	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
702113007567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113007568	dimer interface [polypeptide binding]; other site
702113007569	putative CheW interface [polypeptide binding]; other site
702113007570	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
702113007571	CTP synthetase; Validated; Region: pyrG; PRK05380
702113007572	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
702113007573	Catalytic site [active]
702113007574	active site
702113007575	UTP binding site [chemical binding]; other site
702113007576	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
702113007577	active site
702113007578	putative oxyanion hole; other site
702113007579	catalytic triad [active]
702113007580	protein translocase, SecG subunit; Region: secG; TIGR00810
702113007581	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
702113007582	substrate binding site [chemical binding]; other site
702113007583	dimer interface [polypeptide binding]; other site
702113007584	catalytic triad [active]
702113007585	SurA N-terminal domain; Region: SurA_N_3; cl07813
702113007586	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
702113007587	anthranilate synthase component I; Provisional; Region: PRK13573
702113007588	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
702113007589	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
702113007590	Predicted periplasmic protein [Function unknown]; Region: COG3698
702113007591	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
702113007592	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
702113007593	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
702113007594	glutamine binding [chemical binding]; other site
702113007595	catalytic triad [active]
702113007596	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
702113007597	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
702113007598	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
702113007599	active site
702113007600	ribulose/triose binding site [chemical binding]; other site
702113007601	phosphate binding site [ion binding]; other site
702113007602	substrate (anthranilate) binding pocket [chemical binding]; other site
702113007603	product (indole) binding pocket [chemical binding]; other site
702113007604	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
702113007605	trimer interface [polypeptide binding]; other site
702113007606	dimer interface [polypeptide binding]; other site
702113007607	putative active site [active]
702113007608	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
702113007609	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
702113007610	dimer interface [polypeptide binding]; other site
702113007611	putative functional site; other site
702113007612	putative MPT binding site; other site
702113007613	LexA repressor; Validated; Region: PRK00215
702113007614	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
702113007615	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
702113007616	Catalytic site [active]
702113007617	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
702113007618	Competence protein; Region: Competence; pfam03772
702113007619	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
702113007620	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
702113007621	HIGH motif; other site
702113007622	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
702113007623	active site
702113007624	KMSKS motif; other site
702113007625	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
702113007626	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
702113007627	dimer interface [polypeptide binding]; other site
702113007628	active site
702113007629	citrylCoA binding site [chemical binding]; other site
702113007630	NADH binding [chemical binding]; other site
702113007631	cationic pore residues; other site
702113007632	oxalacetate/citrate binding site [chemical binding]; other site
702113007633	coenzyme A binding site [chemical binding]; other site
702113007634	catalytic triad [active]
702113007635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113007636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007637	ATP binding site [chemical binding]; other site
702113007638	Mg2+ binding site [ion binding]; other site
702113007639	G-X-G motif; other site
702113007640	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
702113007641	hypothetical protein; Validated; Region: PRK09039
702113007642	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
702113007643	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
702113007644	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113007645	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
702113007646	pantothenate kinase; Reviewed; Region: PRK13318
702113007647	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
702113007648	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
702113007649	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
702113007650	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
702113007651	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
702113007652	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
702113007653	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
702113007654	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
702113007655	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
702113007656	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
702113007657	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
702113007658	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
702113007659	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
702113007660	NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213
702113007661	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
702113007662	4Fe-4S binding domain; Region: Fer4; pfam00037
702113007663	4Fe-4S binding domain; Region: Fer4; pfam00037
702113007664	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
702113007665	NADH dehydrogenase subunit G; Validated; Region: PRK09130
702113007666	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113007667	catalytic loop [active]
702113007668	iron binding site [ion binding]; other site
702113007669	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
702113007670	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
702113007671	molybdopterin cofactor binding site; other site
702113007672	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
702113007673	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
702113007674	SLBB domain; Region: SLBB; pfam10531
702113007675	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
702113007676	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
702113007677	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
702113007678	putative dimer interface [polypeptide binding]; other site
702113007679	[2Fe-2S] cluster binding site [ion binding]; other site
702113007680	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
702113007681	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
702113007682	NADH dehydrogenase subunit D; Validated; Region: PRK06075
702113007683	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
702113007684	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
702113007685	NADH dehydrogenase subunit B; Validated; Region: PRK06411
702113007686	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
702113007687	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
702113007688	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113007689	dimer interface [polypeptide binding]; other site
702113007690	active site
702113007691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
702113007692	Bacterial SH3 domain; Region: SH3_4; pfam06347
702113007693	Bacterial SH3 domain; Region: SH3_4; pfam06347
702113007694	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
702113007695	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
702113007696	dimerization interface [polypeptide binding]; other site
702113007697	ligand binding site [chemical binding]; other site
702113007698	NADP binding site [chemical binding]; other site
702113007699	catalytic site [active]
702113007700	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
702113007701	Protein of unknown function (DUF805); Region: DUF805; pfam05656
702113007702	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
702113007703	FMN binding site [chemical binding]; other site
702113007704	substrate binding site [chemical binding]; other site
702113007705	putative catalytic residue [active]
702113007706	Methyltransferase domain; Region: Methyltransf_31; pfam13847
702113007707	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113007708	S-adenosylmethionine binding site [chemical binding]; other site
702113007709	peptide chain release factor 2; Validated; Region: prfB; PRK00578
702113007710	This domain is found in peptide chain release factors; Region: PCRF; smart00937
702113007711	RF-1 domain; Region: RF-1; pfam00472
702113007712	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
702113007713	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
702113007714	catalytic triad [active]
702113007715	oxidoreductase; Provisional; Region: PRK06196
702113007716	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
702113007717	putative NAD(P) binding site [chemical binding]; other site
702113007718	active site
702113007719	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
702113007720	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
702113007721	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
702113007722	PA/protease or protease-like domain interface [polypeptide binding]; other site
702113007723	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
702113007724	Peptidase family M28; Region: Peptidase_M28; pfam04389
702113007725	metal binding site [ion binding]; metal-binding site
702113007726	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
702113007727	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
702113007728	Walker A/P-loop; other site
702113007729	ATP binding site [chemical binding]; other site
702113007730	Q-loop/lid; other site
702113007731	ABC transporter signature motif; other site
702113007732	Walker B; other site
702113007733	D-loop; other site
702113007734	H-loop/switch region; other site
702113007735	ABC transporter; Region: ABC_tran_2; pfam12848
702113007736	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
702113007737	Domain of unknown function (DUF3315); Region: DUF3315; pfam11776
702113007738	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
702113007739	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
702113007740	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
702113007741	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113007742	active site
702113007743	nucleotide binding site [chemical binding]; other site
702113007744	HIGH motif; other site
702113007745	KMSKS motif; other site
702113007746	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
702113007747	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
702113007748	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113007749	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
702113007750	Predicted transcriptional regulators [Transcription]; Region: COG1695
702113007751	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
702113007752	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
702113007753	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
702113007754	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
702113007755	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
702113007756	catalytic core [active]
702113007757	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
702113007758	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
702113007759	DNA binding residues [nucleotide binding]
702113007760	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
702113007761	IHF dimer interface [polypeptide binding]; other site
702113007762	IHF - DNA interface [nucleotide binding]; other site
702113007763	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
702113007764	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
702113007765	dimer interface [polypeptide binding]; other site
702113007766	active site
702113007767	CoA binding pocket [chemical binding]; other site
702113007768	putative phosphate acyltransferase; Provisional; Region: PRK05331
702113007769	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
702113007770	MAPEG family; Region: MAPEG; cl09190
702113007771	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
702113007772	Predicted transcriptional regulator [Transcription]; Region: COG2932
702113007773	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
702113007774	Catalytic site [active]
702113007775	acetolactate synthase; Reviewed; Region: PRK08322
702113007776	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
702113007777	PYR/PP interface [polypeptide binding]; other site
702113007778	dimer interface [polypeptide binding]; other site
702113007779	TPP binding site [chemical binding]; other site
702113007780	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
702113007781	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
702113007782	TPP-binding site [chemical binding]; other site
702113007783	dimer interface [polypeptide binding]; other site
702113007784	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14536
702113007785	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113007786	active site
702113007787	HIGH motif; other site
702113007788	nucleotide binding site [chemical binding]; other site
702113007789	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113007790	active site
702113007791	KMSKS motif; other site
702113007792	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
702113007793	tRNA binding surface [nucleotide binding]; other site
702113007794	anticodon binding site; other site
702113007795	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
702113007796	putative FMN binding site [chemical binding]; other site
702113007797	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
702113007798	cobaltochelatase, CobT subunit; Region: CobT; TIGR01651
702113007799	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
702113007800	metal ion-dependent adhesion site (MIDAS); other site
702113007801	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
702113007802	active site
702113007803	intersubunit interactions; other site
702113007804	catalytic residue [active]
702113007805	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
702113007806	primosome assembly protein PriA; Validated; Region: PRK05580
702113007807	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113007808	ATP binding site [chemical binding]; other site
702113007809	putative Mg++ binding site [ion binding]; other site
702113007810	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
702113007811	bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435
702113007812	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
702113007813	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113007814	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
702113007815	DNA binding site [nucleotide binding]
702113007816	active site
702113007817	Protein of unknown function (DUF1203); Region: DUF1203; pfam06718
702113007818	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
702113007819	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
702113007820	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
702113007821	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
702113007822	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
702113007823	beta subunit interaction interface [polypeptide binding]; other site
702113007824	Walker A motif; other site
702113007825	ATP binding site [chemical binding]; other site
702113007826	Walker B motif; other site
702113007827	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
702113007828	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
702113007829	core domain interface [polypeptide binding]; other site
702113007830	delta subunit interface [polypeptide binding]; other site
702113007831	epsilon subunit interface [polypeptide binding]; other site
702113007832	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
702113007833	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
702113007834	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
702113007835	alpha subunit interaction interface [polypeptide binding]; other site
702113007836	Walker A motif; other site
702113007837	ATP binding site [chemical binding]; other site
702113007838	Walker B motif; other site
702113007839	inhibitor binding site; inhibition site
702113007840	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
702113007841	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
702113007842	gamma subunit interface [polypeptide binding]; other site
702113007843	epsilon subunit interface [polypeptide binding]; other site
702113007844	LBP interface [polypeptide binding]; other site
702113007845	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
702113007846	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
702113007847	ATP binding site [chemical binding]; other site
702113007848	Walker A motif; other site
702113007849	hexamer interface [polypeptide binding]; other site
702113007850	Walker B motif; other site
702113007851	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113007852	EamA-like transporter family; Region: EamA; pfam00892
702113007853	EamA-like transporter family; Region: EamA; pfam00892
702113007854	Entericidin EcnA/B family; Region: Entericidin; cl02322
702113007855	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
702113007856	Sodium Bile acid symporter family; Region: SBF; pfam01758
702113007857	glycine dehydrogenase subunit 2; Validated; Region: PRK04366
702113007858	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007859	catalytic residue [active]
702113007860	glycine dehydrogenase subunit 1; Validated; Region: PRK00451
702113007861	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
702113007862	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007863	catalytic residue [active]
702113007864	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
702113007865	lipoyl attachment site [posttranslational modification]; other site
702113007866	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
702113007867	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
702113007868	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
702113007869	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
702113007870	NAD binding site [chemical binding]; other site
702113007871	active site
702113007872	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
702113007873	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
702113007874	Zn2+ binding site [ion binding]; other site
702113007875	Mg2+ binding site [ion binding]; other site
702113007876	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
702113007877	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
702113007878	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
702113007879	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
702113007880	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
702113007881	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
702113007882	ligand binding site [chemical binding]; other site
702113007883	homodimer interface [polypeptide binding]; other site
702113007884	NAD(P) binding site [chemical binding]; other site
702113007885	trimer interface B [polypeptide binding]; other site
702113007886	trimer interface A [polypeptide binding]; other site
702113007887	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
702113007888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113007889	active site
702113007890	phosphorylation site [posttranslational modification]
702113007891	intermolecular recognition site; other site
702113007892	dimerization interface [polypeptide binding]; other site
702113007893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113007894	Walker A motif; other site
702113007895	ATP binding site [chemical binding]; other site
702113007896	Walker B motif; other site
702113007897	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113007898	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113007899	classical (c) SDRs; Region: SDR_c; cd05233
702113007900	NAD(P) binding site [chemical binding]; other site
702113007901	active site
702113007902	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
702113007903	dihydropteroate synthase; Region: DHPS; TIGR01496
702113007904	substrate binding pocket [chemical binding]; other site
702113007905	dimer interface [polypeptide binding]; other site
702113007906	inhibitor binding site; inhibition site
702113007907	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
702113007908	DNA methylase; Region: N6_N4_Mtase; pfam01555
702113007909	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
702113007910	RNA/DNA hybrid binding site [nucleotide binding]; other site
702113007911	active site
702113007912	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
702113007913	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
702113007914	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113007915	Coenzyme A binding pocket [chemical binding]; other site
702113007916	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
702113007917	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
702113007918	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
702113007919	putative active site [active]
702113007920	putative CoA binding site [chemical binding]; other site
702113007921	nudix motif; other site
702113007922	metal binding site [ion binding]; metal-binding site
702113007923	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
702113007924	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
702113007925	active site
702113007926	NTP binding site [chemical binding]; other site
702113007927	metal binding triad [ion binding]; metal-binding site
702113007928	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
702113007929	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
702113007930	catalytic motif [active]
702113007931	Catalytic residue [active]
702113007932	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
702113007933	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
702113007934	CAP-like domain; other site
702113007935	active site
702113007936	primary dimer interface [polypeptide binding]; other site
702113007937	intracellular protease, PfpI family; Region: PfpI; TIGR01382
702113007938	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
702113007939	proposed catalytic triad [active]
702113007940	conserved cys residue [active]
702113007941	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
702113007942	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113007943	catalytic loop [active]
702113007944	iron binding site [ion binding]; other site
702113007945	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113007946	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
702113007947	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007948	catalytic residue [active]
702113007949	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113007950	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
702113007951	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007952	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113007953	catalytic residue [active]
702113007954	catalytic residue [active]
702113007955	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
702113007956	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113007957	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
702113007958	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
702113007959	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
702113007960	active site
702113007961	substrate-binding site [chemical binding]; other site
702113007962	metal-binding site [ion binding]
702113007963	ATP binding site [chemical binding]; other site
702113007964	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113007965	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113007966	active site
702113007967	phosphorylation site [posttranslational modification]
702113007968	intermolecular recognition site; other site
702113007969	dimerization interface [polypeptide binding]; other site
702113007970	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113007971	DNA binding site [nucleotide binding]
702113007972	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
702113007973	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113007974	HAMP domain; Region: HAMP; pfam00672
702113007975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113007976	dimer interface [polypeptide binding]; other site
702113007977	phosphorylation site [posttranslational modification]
702113007978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113007979	ATP binding site [chemical binding]; other site
702113007980	Mg2+ binding site [ion binding]; other site
702113007981	G-X-G motif; other site
702113007982	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
702113007983	Hpr binding site; other site
702113007984	active site
702113007985	homohexamer subunit interaction site [polypeptide binding]; other site
702113007986	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
702113007987	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
702113007988	active pocket/dimerization site; other site
702113007989	active site
702113007990	phosphorylation site [posttranslational modification]
702113007991	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
702113007992	dimerization domain swap beta strand [polypeptide binding]; other site
702113007993	regulatory protein interface [polypeptide binding]; other site
702113007994	active site
702113007995	regulatory phosphorylation site [posttranslational modification]; other site
702113007996	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
702113007997	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
702113007998	META domain; Region: META; pfam03724
702113007999	DNA recombination protein RmuC; Provisional; Region: PRK10361
702113008000	RmuC family; Region: RmuC; pfam02646
702113008001	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
702113008002	active site
702113008003	catalytic residues [active]
702113008004	metal binding site [ion binding]; metal-binding site
702113008005	recombination protein RecR; Reviewed; Region: recR; PRK00076
702113008006	RecR protein; Region: RecR; pfam02132
702113008007	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
702113008008	putative active site [active]
702113008009	putative metal-binding site [ion binding]; other site
702113008010	tetramer interface [polypeptide binding]; other site
702113008011	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
702113008012	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
702113008013	putative active site [active]
702113008014	substrate binding site [chemical binding]; other site
702113008015	putative cosubstrate binding site; other site
702113008016	catalytic site [active]
702113008017	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
702113008018	substrate binding site [chemical binding]; other site
702113008019	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
702113008020	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
702113008021	dimerization interface 3.5A [polypeptide binding]; other site
702113008022	active site
702113008023	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
702113008024	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
702113008025	NAD(P) binding site [chemical binding]; other site
702113008026	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
702113008027	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
702113008028	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
702113008029	Predicted transcriptional regulators [Transcription]; Region: COG1733
702113008030	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
702113008031	SCP-2 sterol transfer family; Region: SCP2; pfam02036
702113008032	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
702113008033	putative C-terminal domain interface [polypeptide binding]; other site
702113008034	putative GSH binding site (G-site) [chemical binding]; other site
702113008035	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113008036	putative dimer interface [polypeptide binding]; other site
702113008037	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113008038	N-terminal domain interface [polypeptide binding]; other site
702113008039	dimer interface [polypeptide binding]; other site
702113008040	substrate binding pocket (H-site) [chemical binding]; other site
702113008041	Protein of unknown function (DUF1428); Region: DUF1428; pfam07237
702113008042	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
702113008043	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113008044	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
702113008045	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113008046	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113008047	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
702113008048	putative C-terminal domain interface [polypeptide binding]; other site
702113008049	putative GSH binding site (G-site) [chemical binding]; other site
702113008050	putative dimer interface [polypeptide binding]; other site
702113008051	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
702113008052	dimer interface [polypeptide binding]; other site
702113008053	N-terminal domain interface [polypeptide binding]; other site
702113008054	putative substrate binding pocket (H-site) [chemical binding]; other site
702113008055	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
702113008056	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113008057	metal binding site [ion binding]; metal-binding site
702113008058	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113008059	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
702113008060	C-terminal domain interface [polypeptide binding]; other site
702113008061	GSH binding site (G-site) [chemical binding]; other site
702113008062	dimer interface [polypeptide binding]; other site
702113008063	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
702113008064	N-terminal domain interface [polypeptide binding]; other site
702113008065	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896
702113008066	putative hydrophobic ligand binding site [chemical binding]; other site
702113008067	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
702113008068	HSP70 interaction site [polypeptide binding]; other site
702113008069	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
702113008070	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
702113008071	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
702113008072	histidinol dehydrogenase; Region: hisD; TIGR00069
702113008073	NAD binding site [chemical binding]; other site
702113008074	dimerization interface [polypeptide binding]; other site
702113008075	product binding site; other site
702113008076	substrate binding site [chemical binding]; other site
702113008077	zinc binding site [ion binding]; other site
702113008078	catalytic residues [active]
702113008079	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
702113008080	thiamine-monophosphate kinase; Region: thiL; TIGR01379
702113008081	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
702113008082	ATP binding site [chemical binding]; other site
702113008083	dimerization interface [polypeptide binding]; other site
702113008084	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
702113008085	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
702113008086	Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653
702113008087	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
702113008088	Cupin-like domain; Region: Cupin_8; pfam13621
702113008089	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
702113008090	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
702113008091	GIY-YIG motif/motif A; other site
702113008092	active site
702113008093	catalytic site [active]
702113008094	putative DNA binding site [nucleotide binding]; other site
702113008095	metal binding site [ion binding]; metal-binding site
702113008096	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
702113008097	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
702113008098	rRNA binding site [nucleotide binding]; other site
702113008099	predicted 30S ribosome binding site; other site
702113008100	Maf-like protein; Region: Maf; pfam02545
702113008101	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
702113008102	active site
702113008103	dimer interface [polypeptide binding]; other site
702113008104	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
702113008105	multidrug efflux system protein MdtE; Provisional; Region: PRK09859
702113008106	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113008107	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113008108	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
702113008109	copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837
702113008110	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113008111	MarR family; Region: MarR_2; pfam12802
702113008112	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
702113008113	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113008114	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113008115	acyl-activating enzyme (AAE) consensus motif; other site
702113008116	active site
702113008117	CoA binding site [chemical binding]; other site
702113008118	AMP binding site [chemical binding]; other site
702113008119	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113008120	MarR family; Region: MarR; pfam01047
702113008121	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
702113008122	active site
702113008123	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506
702113008124	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
702113008125	CysD dimerization site [polypeptide binding]; other site
702113008126	G1 box; other site
702113008127	putative GEF interaction site [polypeptide binding]; other site
702113008128	GTP/Mg2+ binding site [chemical binding]; other site
702113008129	Switch I region; other site
702113008130	G2 box; other site
702113008131	G3 box; other site
702113008132	Switch II region; other site
702113008133	G4 box; other site
702113008134	G5 box; other site
702113008135	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
702113008136	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
702113008137	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
702113008138	ligand-binding site [chemical binding]; other site
702113008139	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
702113008140	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
702113008141	Active Sites [active]
702113008142	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113008143	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113008144	DNA binding residues [nucleotide binding]
702113008145	dimerization interface [polypeptide binding]; other site
702113008146	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
702113008147	thiamine phosphate binding site [chemical binding]; other site
702113008148	active site
702113008149	pyrophosphate binding site [ion binding]; other site
702113008150	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
702113008151	catalytic residue [active]
702113008152	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
702113008153	Phosphoglycerate kinase; Region: PGK; pfam00162
702113008154	substrate binding site [chemical binding]; other site
702113008155	hinge regions; other site
702113008156	ADP binding site [chemical binding]; other site
702113008157	catalytic site [active]
702113008158	MOSC domain; Region: MOSC; pfam03473
702113008159	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
702113008160	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
702113008161	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
702113008162	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
702113008163	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
702113008164	TPP-binding site [chemical binding]; other site
702113008165	dimer interface [polypeptide binding]; other site
702113008166	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
702113008167	PYR/PP interface [polypeptide binding]; other site
702113008168	dimer interface [polypeptide binding]; other site
702113008169	TPP binding site [chemical binding]; other site
702113008170	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113008171	Cell division protein ZapA; Region: ZapA; pfam05164
702113008172	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
702113008173	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
702113008174	e3 binding domain; Region: E3_binding; pfam02817
702113008175	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
702113008176	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
702113008177	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
702113008178	alpha subunit interface [polypeptide binding]; other site
702113008179	TPP binding site [chemical binding]; other site
702113008180	heterodimer interface [polypeptide binding]; other site
702113008181	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113008182	2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573
702113008183	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
702113008184	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
702113008185	tetramer interface [polypeptide binding]; other site
702113008186	TPP-binding site [chemical binding]; other site
702113008187	heterodimer interface [polypeptide binding]; other site
702113008188	phosphorylation loop region [posttranslational modification]
702113008189	thymidylate synthase; Reviewed; Region: thyA; PRK01827
702113008190	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
702113008191	dimerization interface [polypeptide binding]; other site
702113008192	active site
702113008193	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
702113008194	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
702113008195	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113008196	dimer interface [polypeptide binding]; other site
702113008197	putative CheW interface [polypeptide binding]; other site
702113008198	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
702113008199	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
702113008200	active site
702113008201	non-prolyl cis peptide bond; other site
702113008202	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113008203	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113008204	N-terminal plug; other site
702113008205	ligand-binding site [chemical binding]; other site
702113008206	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113008207	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113008208	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113008209	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113008210	potential protein location (hypothetical protein) that overlaps protein (MscS mechanosensitive ion channel)
702113008211	hypothetical protein; Provisional; Region: PRK06132
702113008212	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113008213	CAAX protease self-immunity; Region: Abi; pfam02517
702113008214	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
702113008215	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
702113008216	active site
702113008217	Zn binding site [ion binding]; other site
702113008218	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113008219	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
702113008220	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
702113008221	active site residue [active]
702113008222	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113008223	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113008224	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
702113008225	putative N-terminal domain interface [polypeptide binding]; other site
702113008226	putative dimer interface [polypeptide binding]; other site
702113008227	putative substrate binding pocket (H-site) [chemical binding]; other site
702113008228	Response regulator receiver domain; Region: Response_reg; pfam00072
702113008229	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008230	active site
702113008231	phosphorylation site [posttranslational modification]
702113008232	intermolecular recognition site; other site
702113008233	dimerization interface [polypeptide binding]; other site
702113008234	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113008235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008236	active site
702113008237	phosphorylation site [posttranslational modification]
702113008238	intermolecular recognition site; other site
702113008239	dimerization interface [polypeptide binding]; other site
702113008240	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113008241	DNA binding residues [nucleotide binding]
702113008242	dimerization interface [polypeptide binding]; other site
702113008243	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113008244	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008245	active site
702113008246	phosphorylation site [posttranslational modification]
702113008247	intermolecular recognition site; other site
702113008248	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113008249	PAS domain; Region: PAS_9; pfam13426
702113008250	putative active site [active]
702113008251	heme pocket [chemical binding]; other site
702113008252	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
702113008253	Histidine kinase; Region: HisKA_3; pfam07730
702113008254	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113008255	ATP binding site [chemical binding]; other site
702113008256	Mg2+ binding site [ion binding]; other site
702113008257	G-X-G motif; other site
702113008258	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113008259	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008260	active site
702113008261	phosphorylation site [posttranslational modification]
702113008262	intermolecular recognition site; other site
702113008263	dimerization interface [polypeptide binding]; other site
702113008264	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
702113008265	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113008266	putative active site [active]
702113008267	heme pocket [chemical binding]; other site
702113008268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113008269	dimer interface [polypeptide binding]; other site
702113008270	phosphorylation site [posttranslational modification]
702113008271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113008272	ATP binding site [chemical binding]; other site
702113008273	Mg2+ binding site [ion binding]; other site
702113008274	G-X-G motif; other site
702113008275	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113008276	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113008277	metal binding site [ion binding]; metal-binding site
702113008278	active site
702113008279	I-site; other site
702113008280	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
702113008281	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
702113008282	ssDNA binding site; other site
702113008283	generic binding surface II; other site
702113008284	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113008285	ATP binding site [chemical binding]; other site
702113008286	putative Mg++ binding site [ion binding]; other site
702113008287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113008288	nucleotide binding region [chemical binding]; other site
702113008289	ATP-binding site [chemical binding]; other site
702113008290	Protein required for attachment to host cells; Region: Host_attach; cl02398
702113008291	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
702113008292	short chain dehydrogenase; Provisional; Region: PRK06949
702113008293	classical (c) SDRs; Region: SDR_c; cd05233
702113008294	NAD(P) binding site [chemical binding]; other site
702113008295	active site
702113008296	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
702113008297	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
702113008298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113008299	ATP binding site [chemical binding]; other site
702113008300	putative Mg++ binding site [ion binding]; other site
702113008301	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113008302	nucleotide binding region [chemical binding]; other site
702113008303	ATP-binding site [chemical binding]; other site
702113008304	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
702113008305	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113008306	metal binding site [ion binding]; metal-binding site
702113008307	active site
702113008308	I-site; other site
702113008309	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113008310	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
702113008311	ATP-NAD kinase; Region: NAD_kinase; pfam01513
702113008312	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
702113008313	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113008314	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
702113008315	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113008316	N-terminal plug; other site
702113008317	ligand-binding site [chemical binding]; other site
702113008318	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
702113008319	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
702113008320	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
702113008321	nucleotide binding region [chemical binding]; other site
702113008322	ATP-binding site [chemical binding]; other site
702113008323	SEC-C motif; Region: SEC-C; pfam02810
702113008324	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
702113008325	heterotetramer interface [polypeptide binding]; other site
702113008326	active site pocket [active]
702113008327	cleavage site
702113008328	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113008329	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
702113008330	putative C-terminal domain interface [polypeptide binding]; other site
702113008331	putative GSH binding site (G-site) [chemical binding]; other site
702113008332	putative dimer interface [polypeptide binding]; other site
702113008333	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
702113008334	putative N-terminal domain interface [polypeptide binding]; other site
702113008335	putative dimer interface [polypeptide binding]; other site
702113008336	putative substrate binding pocket (H-site) [chemical binding]; other site
702113008337	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
702113008338	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
702113008339	active site
702113008340	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
702113008341	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
702113008342	catalytic residues [active]
702113008343	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
702113008344	Family description; Region: UvrD_C_2; pfam13538
702113008345	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
702113008346	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
702113008347	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
702113008348	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
702113008349	Substrate binding site; other site
702113008350	metal-binding site
702113008351	Phosphotransferase enzyme family; Region: APH; pfam01636
702113008352	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
702113008353	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
702113008354	PAS fold; Region: PAS_7; pfam12860
702113008355	PAS fold; Region: PAS_7; pfam12860
702113008356	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113008357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113008358	dimer interface [polypeptide binding]; other site
702113008359	phosphorylation site [posttranslational modification]
702113008360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113008361	ATP binding site [chemical binding]; other site
702113008362	Mg2+ binding site [ion binding]; other site
702113008363	G-X-G motif; other site
702113008364	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
702113008365	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
702113008366	homotetramer interface [polypeptide binding]; other site
702113008367	ligand binding site [chemical binding]; other site
702113008368	catalytic site [active]
702113008369	NAD binding site [chemical binding]; other site
702113008370	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
702113008371	catalytic triad [active]
702113008372	dimer interface [polypeptide binding]; other site
702113008373	short chain dehydrogenase; Provisional; Region: PRK12828
702113008374	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113008375	NAD(P) binding site [chemical binding]; other site
702113008376	active site
702113008377	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
702113008378	GTP cyclohydrolase I; Provisional; Region: PLN03044
702113008379	active site
702113008380	Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140
702113008381	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
702113008382	putative active site [active]
702113008383	putative active site [active]
702113008384	catalytic site [active]
702113008385	catalytic site [active]
702113008386	Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143
702113008387	PLD-like domain; Region: PLDc_2; pfam13091
702113008388	putative active site [active]
702113008389	catalytic site [active]
702113008390	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
702113008391	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
702113008392	putative ion selectivity filter; other site
702113008393	putative pore gating glutamate residue; other site
702113008394	putative H+/Cl- coupling transport residue; other site
702113008395	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
702113008396	active site
702113008397	8-oxo-dGMP binding site [chemical binding]; other site
702113008398	nudix motif; other site
702113008399	metal binding site [ion binding]; metal-binding site
702113008400	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
702113008401	Putative Zn-dependent protease [General function prediction only]; Region: COG4784
702113008402	Peptidase family M48; Region: Peptidase_M48; pfam01435
702113008403	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
702113008404	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
702113008405	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113008406	active site
702113008407	DNA binding site [nucleotide binding]
702113008408	Int/Topo IB signature motif; other site
702113008409	shikimate kinase; Provisional; Region: PRK13946
702113008410	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
702113008411	magnesium binding site [ion binding]; other site
702113008412	putative shikimate binding site; other site
702113008413	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
702113008414	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
702113008415	active site
702113008416	dimer interface [polypeptide binding]; other site
702113008417	metal binding site [ion binding]; metal-binding site
702113008418	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113008419	putative substrate translocation pore; other site
702113008420	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113008421	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
702113008422	active site 2 [active]
702113008423	active site 1 [active]
702113008424	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
702113008425	dimer interface [polypeptide binding]; other site
702113008426	putative tRNA-binding site [nucleotide binding]; other site
702113008427	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
702113008428	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113008429	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113008430	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
702113008431	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
702113008432	carboxyltransferase (CT) interaction site; other site
702113008433	biotinylation site [posttranslational modification]; other site
702113008434	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
702113008435	biotin synthase; Region: bioB; TIGR00433
702113008436	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113008437	FeS/SAM binding site; other site
702113008438	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
702113008439	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
702113008440	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
702113008441	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
702113008442	active site
702113008443	substrate binding site [chemical binding]; other site
702113008444	coenzyme B12 binding site [chemical binding]; other site
702113008445	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
702113008446	B12 binding site [chemical binding]; other site
702113008447	cobalt ligand [ion binding]; other site
702113008448	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113008449	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
702113008450	dimer interface [polypeptide binding]; other site
702113008451	substrate binding site [chemical binding]; other site
702113008452	metal binding site [ion binding]; metal-binding site
702113008453	beta-ketothiolase; Provisional; Region: PRK09051
702113008454	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113008455	dimer interface [polypeptide binding]; other site
702113008456	active site
702113008457	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
702113008458	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
702113008459	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
702113008460	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
702113008461	glutathione reductase; Validated; Region: PRK06116
702113008462	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113008463	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
702113008464	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
702113008465	catalytic triad [active]
702113008466	putative active site [active]
702113008467	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
702113008468	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
702113008469	active site
702113008470	dimer interface [polypeptide binding]; other site
702113008471	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
702113008472	dimer interface [polypeptide binding]; other site
702113008473	active site
702113008474	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
702113008475	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
702113008476	Catalytic site [active]
702113008477	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
702113008478	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
702113008479	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
702113008480	dimerization interface [polypeptide binding]; other site
702113008481	active site
702113008482	metal binding site [ion binding]; metal-binding site
702113008483	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
702113008484	dsRNA binding site [nucleotide binding]; other site
702113008485	GTPase Era; Reviewed; Region: era; PRK00089
702113008486	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
702113008487	G1 box; other site
702113008488	GTP/Mg2+ binding site [chemical binding]; other site
702113008489	Switch I region; other site
702113008490	G2 box; other site
702113008491	Switch II region; other site
702113008492	G3 box; other site
702113008493	G4 box; other site
702113008494	G5 box; other site
702113008495	KH domain; Region: KH_2; pfam07650
702113008496	SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823
702113008497	active site
702113008498	catalytic triad [active]
702113008499	oxyanion hole [active]
702113008500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113008501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113008502	putative substrate translocation pore; other site
702113008503	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
702113008504	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
702113008505	active site
702113008506	interdomain interaction site; other site
702113008507	putative metal-binding site [ion binding]; other site
702113008508	nucleotide binding site [chemical binding]; other site
702113008509	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
702113008510	domain I; other site
702113008511	DNA binding groove [nucleotide binding]
702113008512	phosphate binding site [ion binding]; other site
702113008513	domain II; other site
702113008514	domain III; other site
702113008515	nucleotide binding site [chemical binding]; other site
702113008516	catalytic site [active]
702113008517	domain IV; other site
702113008518	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
702113008519	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
702113008520	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
702113008521	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
702113008522	DNA protecting protein DprA; Region: dprA; TIGR00732
702113008523	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
702113008524	glutamate racemase; Provisional; Region: PRK00865
702113008525	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
702113008526	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
702113008527	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
702113008528	substrate-cofactor binding pocket; other site
702113008529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113008530	catalytic residue [active]
702113008531	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113008532	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
702113008533	active site
702113008534	FMN binding site [chemical binding]; other site
702113008535	substrate binding site [chemical binding]; other site
702113008536	homotetramer interface [polypeptide binding]; other site
702113008537	catalytic residue [active]
702113008538	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
702113008539	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113008540	catalytic residue [active]
702113008541	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
702113008542	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
702113008543	dimer interface [polypeptide binding]; other site
702113008544	active site
702113008545	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113008546	catalytic residues [active]
702113008547	substrate binding site [chemical binding]; other site
702113008548	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
702113008549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113008550	Protein of unknown function (DUF3419); Region: DUF3419; pfam11899
702113008551	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
702113008552	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
702113008553	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113008554	catalytic residue [active]
702113008555	MAPEG family; Region: MAPEG; pfam01124
702113008556	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
702113008557	Uncharacterized conserved protein [Function unknown]; Region: COG0062
702113008558	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
702113008559	putative substrate binding site [chemical binding]; other site
702113008560	putative ATP binding site [chemical binding]; other site
702113008561	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
702113008562	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
702113008563	N-formylglutamate amidohydrolase; Region: FGase; cl01522
702113008564	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
702113008565	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
702113008566	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
702113008567	hydroxyglutarate oxidase; Provisional; Region: PRK11728
702113008568	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
702113008569	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
702113008570	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
702113008571	active site
702113008572	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
702113008573	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113008574	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113008575	catalytic residue [active]
702113008576	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
702113008577	MPT binding site; other site
702113008578	trimer interface [polypeptide binding]; other site
702113008579	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
702113008580	Cytochrome P450; Region: p450; cl12078
702113008581	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
702113008582	phosphoglucomutase; Region: PLN02307
702113008583	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
702113008584	active site
702113008585	substrate binding site [chemical binding]; other site
702113008586	metal binding site [ion binding]; metal-binding site
702113008587	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113008588	DNA binding residues [nucleotide binding]
702113008589	adenylosuccinate lyase; Provisional; Region: PRK07492
702113008590	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
702113008591	tetramer interface [polypeptide binding]; other site
702113008592	active site
702113008593	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
702113008594	active site
702113008595	dimer interface [polypeptide binding]; other site
702113008596	Uncharacterized conserved protein [Function unknown]; Region: COG2968
702113008597	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
702113008598	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
702113008599	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
702113008600	active site
702113008601	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
702113008602	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
702113008603	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
702113008604	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113008605	catalytic residue [active]
702113008606	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
702113008607	substrate binding site [chemical binding]; other site
702113008608	active site
702113008609	catalytic residues [active]
702113008610	heterodimer interface [polypeptide binding]; other site
702113008611	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
702113008612	muropeptide transporter; Validated; Region: ampG; cl17669
702113008613	muropeptide transporter; Validated; Region: ampG; cl17669
702113008614	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
702113008615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
702113008616	RNA binding surface [nucleotide binding]; other site
702113008617	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
702113008618	active site
702113008619	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
702113008620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
702113008621	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
702113008622	Part of AAA domain; Region: AAA_19; pfam13245
702113008623	Family description; Region: UvrD_C_2; pfam13538
702113008624	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
702113008625	DEAD-like helicases superfamily; Region: DEXDc; smart00487
702113008626	ATP binding site [chemical binding]; other site
702113008627	Mg++ binding site [ion binding]; other site
702113008628	motif III; other site
702113008629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113008630	nucleotide binding region [chemical binding]; other site
702113008631	ATP-binding site [chemical binding]; other site
702113008632	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
702113008633	FAD binding domain; Region: FAD_binding_4; pfam01565
702113008634	SapC; Region: SapC; pfam07277
702113008635	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
702113008636	Response regulator receiver domain; Region: Response_reg; pfam00072
702113008637	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008638	active site
702113008639	phosphorylation site [posttranslational modification]
702113008640	intermolecular recognition site; other site
702113008641	dimerization interface [polypeptide binding]; other site
702113008642	isocitrate dehydrogenase; Validated; Region: PRK08299
702113008643	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
702113008644	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
702113008645	FeS/SAM binding site; other site
702113008646	putative acyl-CoA synthetase; Provisional; Region: PRK06018
702113008647	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
702113008648	dimer interface [polypeptide binding]; other site
702113008649	acyl-activating enzyme (AAE) consensus motif; other site
702113008650	putative active site [active]
702113008651	AMP binding site [chemical binding]; other site
702113008652	putative CoA binding site [chemical binding]; other site
702113008653	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
702113008654	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
702113008655	putative active site [active]
702113008656	putative PHP Thumb interface [polypeptide binding]; other site
702113008657	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
702113008658	generic binding surface II; other site
702113008659	generic binding surface I; other site
702113008660	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
702113008661	catalytic residues [active]
702113008662	dimer interface [polypeptide binding]; other site
702113008663	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
702113008664	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
702113008665	Walker A/P-loop; other site
702113008666	ATP binding site [chemical binding]; other site
702113008667	Q-loop/lid; other site
702113008668	ABC transporter signature motif; other site
702113008669	Walker B; other site
702113008670	D-loop; other site
702113008671	H-loop/switch region; other site
702113008672	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
702113008673	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
702113008674	FtsX-like permease family; Region: FtsX; pfam02687
702113008675	amidophosphoribosyltransferase; Provisional; Region: PRK09123
702113008676	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
702113008677	active site
702113008678	tetramer interface [polypeptide binding]; other site
702113008679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113008680	active site
702113008681	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
702113008682	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113008683	NAD(P) binding site [chemical binding]; other site
702113008684	active site
702113008685	PilZ domain; Region: PilZ; pfam07238
702113008686	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
702113008687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113008688	S-adenosylmethionine binding site [chemical binding]; other site
702113008689	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
702113008690	DNA photolyase; Region: DNA_photolyase; pfam00875
702113008691	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
702113008692	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
702113008693	active site
702113008694	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
702113008695	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
702113008696	TPP-binding site [chemical binding]; other site
702113008697	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
702113008698	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
702113008699	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
702113008700	dimer interface [polypeptide binding]; other site
702113008701	PYR/PP interface [polypeptide binding]; other site
702113008702	TPP binding site [chemical binding]; other site
702113008703	substrate binding site [chemical binding]; other site
702113008704	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
702113008705	putative active site [active]
702113008706	Ap4A binding site [chemical binding]; other site
702113008707	nudix motif; other site
702113008708	putative metal binding site [ion binding]; other site
702113008709	TPR repeat; Region: TPR_11; pfam13414
702113008710	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113008711	binding surface
702113008712	TPR motif; other site
702113008713	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
702113008714	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
702113008715	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
702113008716	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
702113008717	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
702113008718	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
702113008719	active site
702113008720	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
702113008721	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
702113008722	Peptidase family M28; Region: Peptidase_M28; pfam04389
702113008723	metal binding site [ion binding]; metal-binding site
702113008724	Predicted metalloprotease [General function prediction only]; Region: COG2321
702113008725	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
702113008726	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
702113008727	Predicted transcriptional regulator [Transcription]; Region: COG3682
702113008728	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
702113008729	L-aspartate oxidase; Provisional; Region: PRK06175
702113008730	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
702113008731	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
702113008732	putative SdhC subunit interface [polypeptide binding]; other site
702113008733	putative proximal heme binding site [chemical binding]; other site
702113008734	putative Iron-sulfur protein interface [polypeptide binding]; other site
702113008735	putative proximal quinone binding site; other site
702113008736	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
702113008737	Iron-sulfur protein interface; other site
702113008738	proximal quinone binding site [chemical binding]; other site
702113008739	SdhD (CybS) interface [polypeptide binding]; other site
702113008740	proximal heme binding site [chemical binding]; other site
702113008741	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113008742	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
702113008743	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
702113008744	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
702113008745	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
702113008746	nucleotide binding pocket [chemical binding]; other site
702113008747	K-X-D-G motif; other site
702113008748	catalytic site [active]
702113008749	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
702113008750	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
702113008751	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
702113008752	Dimer interface [polypeptide binding]; other site
702113008753	BRCT sequence motif; other site
702113008754	Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290
702113008755	Domain of unknown function (DUF4396); Region: DUF4396; pfam14342
702113008756	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
702113008757	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
702113008758	Walker A/P-loop; other site
702113008759	ATP binding site [chemical binding]; other site
702113008760	Q-loop/lid; other site
702113008761	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
702113008762	ABC transporter signature motif; other site
702113008763	Walker B; other site
702113008764	D-loop; other site
702113008765	H-loop/switch region; other site
702113008766	Rrf2 family protein; Region: rrf2_super; TIGR00738
702113008767	Transcriptional regulator; Region: Rrf2; pfam02082
702113008768	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
702113008769	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
702113008770	TrkA-N domain; Region: TrkA_N; pfam02254
702113008771	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
702113008772	glutaminase; Provisional; Region: PRK00971
702113008773	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
702113008774	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
702113008775	motif 1; other site
702113008776	active site
702113008777	motif 2; other site
702113008778	motif 3; other site
702113008779	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
702113008780	DHHA1 domain; Region: DHHA1; pfam02272
702113008781	recombinase A; Provisional; Region: recA; PRK09354
702113008782	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
702113008783	hexamer interface [polypeptide binding]; other site
702113008784	Walker A motif; other site
702113008785	ATP binding site [chemical binding]; other site
702113008786	Walker B motif; other site
702113008787	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
702113008788	PAS domain; Region: PAS; smart00091
702113008789	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113008790	dimer interface [polypeptide binding]; other site
702113008791	phosphorylation site [posttranslational modification]
702113008792	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113008793	ATP binding site [chemical binding]; other site
702113008794	Mg2+ binding site [ion binding]; other site
702113008795	G-X-G motif; other site
702113008796	Response regulator receiver domain; Region: Response_reg; pfam00072
702113008797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113008798	active site
702113008799	phosphorylation site [posttranslational modification]
702113008800	intermolecular recognition site; other site
702113008801	dimerization interface [polypeptide binding]; other site
702113008802	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
702113008803	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
702113008804	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
702113008805	SmpB-tmRNA interface; other site
702113008806	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113008807	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113008808	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
702113008809	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
702113008810	dimer interface [polypeptide binding]; other site
702113008811	active site
702113008812	catalytic residue [active]
702113008813	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
702113008814	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113008815	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113008816	catalytic residue [active]
702113008817	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
702113008818	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
702113008819	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
702113008820	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_21; cd04680
702113008821	nudix motif; other site
702113008822	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
702113008823	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
702113008824	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
702113008825	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113008826	ligand binding site [chemical binding]; other site
702113008827	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
702113008828	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113008829	active site
702113008830	Int/Topo IB signature motif; other site
702113008831	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
702113008832	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
702113008833	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
702113008834	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
702113008835	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113008836	acyl-activating enzyme (AAE) consensus motif; other site
702113008837	AMP binding site [chemical binding]; other site
702113008838	active site
702113008839	CoA binding site [chemical binding]; other site
702113008840	EamA-like transporter family; Region: EamA; pfam00892
702113008841	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113008842	EamA-like transporter family; Region: EamA; pfam00892
702113008843	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113008844	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113008845	iron-sulfur cluster [ion binding]; other site
702113008846	[2Fe-2S] cluster binding site [ion binding]; other site
702113008847	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113008848	beta subunit interface [polypeptide binding]; other site
702113008849	alpha subunit interface [polypeptide binding]; other site
702113008850	active site
702113008851	substrate binding site [chemical binding]; other site
702113008852	Fe binding site [ion binding]; other site
702113008853	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113008854	inter-subunit interface; other site
702113008855	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
702113008856	Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278
702113008857	catalytic Zn binding site [ion binding]; other site
702113008858	NAD binding site [chemical binding]; other site
702113008859	structural Zn binding site [ion binding]; other site
702113008860	pyruvate phosphate dikinase; Provisional; Region: PRK09279
702113008861	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
702113008862	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
702113008863	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113008864	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
702113008865	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
702113008866	active site
702113008867	inhibitor site; inhibition site
702113008868	dimer interface [polypeptide binding]; other site
702113008869	catalytic residue [active]
702113008870	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
702113008871	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
702113008872	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
702113008873	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
702113008874	tartrate dehydrogenase; Region: TTC; TIGR02089
702113008875	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
702113008876	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
702113008877	active site
702113008878	non-prolyl cis peptide bond; other site
702113008879	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
702113008880	BphX-like; Region: BphX; pfam06139
702113008881	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
702113008882	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113008883	catalytic loop [active]
702113008884	iron binding site [ion binding]; other site
702113008885	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
702113008886	Cytochrome P450; Region: p450; cl12078
702113008887	DDE superfamily endonuclease; Region: DDE_5; cl17874
702113008888	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
702113008889	Fatty acid desaturase; Region: FA_desaturase; pfam00487
702113008890	putative di-iron ligands [ion binding]; other site
702113008891	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
702113008892	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
702113008893	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113008894	homotrimer interaction site [polypeptide binding]; other site
702113008895	putative active site [active]
702113008896	potential frameshift: common BLAST hit: gi|146275444|ref|YP_001165605.1| amidohydrolase 2
702113008897	Amidohydrolase; Region: Amidohydro_2; pfam04909
702113008898	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
702113008899	active site
702113008900	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
702113008901	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113008902	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113008903	[2Fe-2S] cluster binding site [ion binding]; other site
702113008904	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
702113008905	hydrophobic ligand binding site; other site
702113008906	Trans-o-hydroxybenzylidenepyruvate hydratase-aldolase (HBPHA) and trans-2'-carboxybenzalpyruvate hydratase-aldolase (CBPHA); Region: CHBPH_aldolase; cd00952
702113008907	dihydrodipicolinate synthase; Region: dapA; TIGR00674
702113008908	putative active site [active]
702113008909	catalytic residue [active]
702113008910	1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823
702113008911	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113008912	NAD(P) binding site [chemical binding]; other site
702113008913	active site
702113008914	potential frameshift: common BLAST hit: gi|10956962|ref|NP_049182.1| ferredoxin reductase subunit aromatic oxygenase
702113008915	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
702113008916	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113008917	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113008918	Activator of aromatic catabolism; Region: XylR_N; pfam06505
702113008919	V4R domain; Region: V4R; pfam02830
702113008920	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113008921	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
702113008922	Walker A motif; other site
702113008923	ATP binding site [chemical binding]; other site
702113008924	Walker B motif; other site
702113008925	arginine finger; other site
702113008926	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113008927	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113008928	iron-sulfur cluster [ion binding]; other site
702113008929	[2Fe-2S] cluster binding site [ion binding]; other site
702113008930	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113008931	beta subunit interface [polypeptide binding]; other site
702113008932	alpha subunit interface [polypeptide binding]; other site
702113008933	active site
702113008934	substrate binding site [chemical binding]; other site
702113008935	Fe binding site [ion binding]; other site
702113008936	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113008937	inter-subunit interface; other site
702113008938	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113008939	iron-sulfur cluster [ion binding]; other site
702113008940	[2Fe-2S] cluster binding site [ion binding]; other site
702113008941	C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881
702113008942	beta subunit interface [polypeptide binding]; other site
702113008943	alpha subunit interface [polypeptide binding]; other site
702113008944	active site
702113008945	substrate binding site [chemical binding]; other site
702113008946	Fe binding site [ion binding]; other site
702113008947	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113008948	inter-subunit interface; other site
702113008949	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
702113008950	Fatty acid desaturase; Region: FA_desaturase; pfam00487
702113008951	Di-iron ligands [ion binding]; other site
702113008952	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113008953	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
702113008954	catalytic loop [active]
702113008955	iron binding site [ion binding]; other site
702113008956	The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S] ferredoxin center (fused to the FAD...; Region: oxygenase_e_transfer_subunit; cd06213
702113008957	FAD binding pocket [chemical binding]; other site
702113008958	FAD binding motif [chemical binding]; other site
702113008959	phosphate binding motif [ion binding]; other site
702113008960	beta-alpha-beta structure motif; other site
702113008961	NAD binding pocket [chemical binding]; other site
702113008962	Uncharacterized conserved protein [Function unknown]; Region: COG3777
702113008963	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113008964	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113008965	active site 2 [active]
702113008966	active site 1 [active]
702113008967	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113008968	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113008969	active site
702113008970	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
702113008971	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113008972	dimer interface [polypeptide binding]; other site
702113008973	active site
702113008974	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
702113008975	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113008976	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113008977	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113008978	active site
702113008979	short chain dehydrogenase; Provisional; Region: PRK07791
702113008980	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113008981	NAD(P) binding site [chemical binding]; other site
702113008982	active site
702113008983	Transcriptional regulator [Transcription]; Region: IclR; COG1414
702113008984	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
702113008985	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113008986	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113008987	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113008988	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113008989	active site
702113008990	enoyl-CoA hydratase; Region: PLN02864
702113008991	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113008992	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
702113008993	dimer interaction site [polypeptide binding]; other site
702113008994	substrate-binding tunnel; other site
702113008995	active site
702113008996	catalytic site [active]
702113008997	substrate binding site [chemical binding]; other site
702113008998	DDE superfamily endonuclease; Region: DDE_3; pfam13358
702113008999	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
702113009000	Integrase core domain; Region: rve; pfam00665
702113009001	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
702113009002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113009003	Walker A motif; other site
702113009004	ATP binding site [chemical binding]; other site
702113009005	Walker B motif; other site
702113009006	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
702113009007	Homeodomain-like domain; Region: HTH_23; pfam13384
702113009008	Transposase; Region: HTH_Tnp_1; pfam01527
702113009009	2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200
702113009010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113009011	NAD(P) binding site [chemical binding]; other site
702113009012	active site
702113009013	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
702113009014	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113009015	NAD(P) binding site [chemical binding]; other site
702113009016	catalytic residues [active]
702113009017	Tautomerase enzyme; Region: Tautomerase; pfam01361
702113009018	active site 1 [active]
702113009019	dimer interface [polypeptide binding]; other site
702113009020	hexamer interface [polypeptide binding]; other site
702113009021	active site 2 [active]
702113009022	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113009023	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
702113009024	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
702113009025	active site
702113009026	catalytic residues [active]
702113009027	metal binding site [ion binding]; metal-binding site
702113009028	DmpG-like communication domain; Region: DmpG_comm; pfam07836
702113009029	acetaldehyde dehydrogenase; Validated; Region: PRK08300
702113009030	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113009031	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
702113009032	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113009033	2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216
702113009034	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
702113009035	NAD binding site [chemical binding]; other site
702113009036	catalytic residues [active]
702113009037	Domain of unknown function (DUF336); Region: DUF336; pfam03928
702113009038	catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211
702113009039	N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265
702113009040	tetramer interface [polypeptide binding]; other site
702113009041	C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243
702113009042	tetramer interface [polypeptide binding]; other site
702113009043	active site
702113009044	Fe binding site [ion binding]; other site
702113009045	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
702113009046	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113009047	glutathionine S-transferase; Provisional; Region: PRK10542
702113009048	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
702113009049	C-terminal domain interface [polypeptide binding]; other site
702113009050	GSH binding site (G-site) [chemical binding]; other site
702113009051	dimer interface [polypeptide binding]; other site
702113009052	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
702113009053	dimer interface [polypeptide binding]; other site
702113009054	N-terminal domain interface [polypeptide binding]; other site
702113009055	substrate binding pocket (H-site) [chemical binding]; other site
702113009056	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113009057	inter-subunit interface; other site
702113009058	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113009059	iron-sulfur cluster [ion binding]; other site
702113009060	[2Fe-2S] cluster binding site [ion binding]; other site
702113009061	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
702113009062	putative alpha subunit interface [polypeptide binding]; other site
702113009063	putative active site [active]
702113009064	putative substrate binding site [chemical binding]; other site
702113009065	Fe binding site [ion binding]; other site
702113009066	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
702113009067	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; pfam04166
702113009068	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113009069	inter-subunit interface; other site
702113009070	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113009071	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113009072	iron-sulfur cluster [ion binding]; other site
702113009073	[2Fe-2S] cluster binding site [ion binding]; other site
702113009074	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
702113009075	putative alpha subunit interface [polypeptide binding]; other site
702113009076	putative active site [active]
702113009077	putative substrate binding site [chemical binding]; other site
702113009078	Fe binding site [ion binding]; other site
702113009079	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113009080	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
702113009081	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
702113009082	active site
702113009083	Fe binding site [ion binding]; other site
702113009084	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
702113009085	[2Fe-2S] cluster binding site [ion binding]; other site
702113009086	Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667
702113009087	inter-subunit interface; other site
702113009088	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113009089	Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545
702113009090	C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880
702113009091	putative alpha subunit interface [polypeptide binding]; other site
702113009092	putative active site [active]
702113009093	putative substrate binding site [chemical binding]; other site
702113009094	Fe binding site [ion binding]; other site
702113009095	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
702113009096	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
702113009097	putative catalytic residue [active]
702113009098	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113009099	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113009100	N-terminal plug; other site
702113009101	ligand-binding site [chemical binding]; other site
702113009102	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113009103	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113009104	N-terminal plug; other site
702113009105	ligand-binding site [chemical binding]; other site
702113009106	succinic semialdehyde dehydrogenase; Region: PLN02278
702113009107	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
702113009108	tetramerization interface [polypeptide binding]; other site
702113009109	NAD(P) binding site [chemical binding]; other site
702113009110	catalytic residues [active]
702113009111	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
702113009112	Flavoprotein; Region: Flavoprotein; pfam02441
702113009113	FAD binding domain; Region: FAD_binding_4; pfam01565
702113009114	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
702113009115	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113009116	Pseudomonas putida vanillin dehydrogenase-like; Region: ALDH_VaniDH_like; cd07150
702113009117	NAD(P) binding site [chemical binding]; other site
702113009118	catalytic residues [active]
702113009119	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
702113009120	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
702113009121	FAD binding domain; Region: FAD_binding_4; pfam01565
702113009122	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113009123	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
702113009124	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113009125	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113009126	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113009127	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113009128	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113009129	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113009130	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113009131	putative substrate translocation pore; other site
702113009132	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
702113009133	Transcriptional regulator [Transcription]; Region: IclR; COG1414
702113009134	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113009135	Predicted permeases [General function prediction only]; Region: RarD; COG2962
702113009136	enoyl-CoA hydratase; Region: PLN02864
702113009137	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113009138	HDE_HSD  The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins.  Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448
702113009139	dimer interaction site [polypeptide binding]; other site
702113009140	substrate-binding tunnel; other site
702113009141	active site
702113009142	catalytic site [active]
702113009143	substrate binding site [chemical binding]; other site
702113009144	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113009145	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113009146	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113009147	active site
702113009148	Transcriptional regulator [Transcription]; Region: IclR; COG1414
702113009149	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
702113009150	short chain dehydrogenase; Provisional; Region: PRK07791
702113009151	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113009152	NAD(P) binding site [chemical binding]; other site
702113009153	active site
702113009154	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113009155	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113009156	active site
702113009157	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
702113009158	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113009159	acetyl-CoA acetyltransferase; Provisional; Region: PRK06205
702113009160	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113009161	dimer interface [polypeptide binding]; other site
702113009162	active site
702113009163	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113009164	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113009165	active site
702113009166	Uncharacterized conserved protein [Function unknown]; Region: COG3777
702113009167	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113009168	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113009169	active site 2 [active]
702113009170	active site 1 [active]
702113009171	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113009172	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
702113009173	Presynaptic Site I dimer interface [polypeptide binding]; other site
702113009174	catalytic residues [active]
702113009175	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
702113009176	Synaptic Flat tetramer interface [polypeptide binding]; other site
702113009177	Synaptic Site I dimer interface [polypeptide binding]; other site
702113009178	DNA binding site [nucleotide binding]
702113009179	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113009180	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113009181	TrwC relaxase; Region: TrwC; pfam08751
702113009182	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
702113009183	AAA domain; Region: AAA_30; pfam13604
702113009184	Family description; Region: UvrD_C_2; pfam13538
702113009185	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113009186	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
702113009187	Walker A motif; other site
702113009188	ATP binding site [chemical binding]; other site
702113009189	Walker B motif; other site
702113009190	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113009191	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
702113009192	Protein of unknown function (DUF736); Region: DUF736; pfam05284
702113009193	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
702113009194	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
702113009195	Ligand Binding Site [chemical binding]; other site
702113009196	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; pfam02899
702113009197	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
702113009198	active site
702113009199	catalytic residues [active]
702113009200	DNA binding site [nucleotide binding]
702113009201	Int/Topo IB signature motif; other site
702113009202	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
702113009203	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
702113009204	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
702113009205	active site 1 [active]
702113009206	active site 2 [active]
702113009207	Methyltransferase domain; Region: Methyltransf_26; pfam13659
702113009208	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
702113009209	Helicase_C-like; Region: Helicase_C_4; pfam13871
702113009210	ParB-like nuclease domain; Region: ParB; smart00470
702113009211	KorB domain; Region: KorB; pfam08535
702113009212	CHC2 zinc finger; Region: zf-CHC2; cl17510
702113009213	Toprim domain; Region: Toprim_3; pfam13362
702113009214	active site
702113009215	metal binding site [ion binding]; metal-binding site
702113009216	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
702113009217	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
702113009218	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
702113009219	active site
702113009220	NTP binding site [chemical binding]; other site
702113009221	metal binding triad [ion binding]; metal-binding site
702113009222	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
702113009223	Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480
702113009224	AAA domain; Region: AAA_13; pfam13166
702113009225	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
702113009226	active site
702113009227	GIY-YIG motif/motif A; other site
702113009228	catalytic site [active]
702113009229	metal binding site [ion binding]; metal-binding site
702113009230	Restriction endonuclease; Region: Mrr_cat; pfam04471
702113009231	NACHT domain; Region: NACHT; pfam05729
702113009232	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
702113009233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113009234	sequence-specific DNA binding site [nucleotide binding]; other site
702113009235	salt bridge; other site
702113009236	Domain of unknown function (DUF955); Region: DUF955; cl01076
702113009237	Autoinducer synthetase; Region: Autoind_synth; cl17404
702113009238	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113009239	DNA binding residues [nucleotide binding]
702113009240	dimerization interface [polypeptide binding]; other site
702113009241	Homeodomain-like domain; Region: HTH_23; cl17451
702113009242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
702113009243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113009244	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113009245	NAD(P) binding site [chemical binding]; other site
702113009246	active site
702113009247	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113009248	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113009249	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
702113009250	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113009251	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113009252	active site
702113009253	metal binding site [ion binding]; metal-binding site
702113009254	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113009255	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113009256	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113009257	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113009258	putative substrate translocation pore; other site
702113009259	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
702113009260	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113009261	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
702113009262	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113009263	active site
702113009264	metal binding site [ion binding]; metal-binding site
702113009265	short chain dehydrogenase; Provisional; Region: PRK06500
702113009266	classical (c) SDRs; Region: SDR_c; cd05233
702113009267	NAD(P) binding site [chemical binding]; other site
702113009268	active site
702113009269	short chain dehydrogenase; Provisional; Region: PRK06523
702113009270	classical (c) SDRs; Region: SDR_c; cd05233
702113009271	NAD(P) binding site [chemical binding]; other site
702113009272	active site
702113009273	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113009274	DNA-binding site [nucleotide binding]; DNA binding site
702113009275	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
702113009276	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113009277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113009278	homodimer interface [polypeptide binding]; other site
702113009279	catalytic residue [active]
702113009280	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
702113009281	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
702113009282	Predicted oxidoreductase [General function prediction only]; Region: COG3573
702113009283	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
702113009284	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
702113009285	active site
702113009286	catalytic residues [active]
702113009287	metal binding site [ion binding]; metal-binding site
702113009288	DmpG-like communication domain; Region: DmpG_comm; pfam07836
702113009289	acetaldehyde dehydrogenase; Validated; Region: PRK08300
702113009290	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113009291	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
702113009292	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113009293	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
702113009294	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
702113009295	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
702113009296	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
702113009297	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
702113009298	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
702113009299	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113009300	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113009301	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113009302	active site
702113009303	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113009304	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113009305	NAD(P) binding site [chemical binding]; other site
702113009306	active site
702113009307	D-lactate dehydrogenase; Provisional; Region: PRK11183
702113009308	FAD binding domain; Region: FAD_binding_4; pfam01565
702113009309	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
702113009310	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113009311	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
702113009312	dimer interface [polypeptide binding]; other site
702113009313	active site
702113009314	metal binding site [ion binding]; metal-binding site
702113009315	glutathione binding site [chemical binding]; other site
702113009316	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
702113009317	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
702113009318	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113009319	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113009320	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113009321	dimerization interface [polypeptide binding]; other site
702113009322	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
702113009323	Winged helix-turn helix; Region: HTH_29; pfam13551
702113009324	Helix-turn-helix domain; Region: HTH_28; pfam13518
702113009325	Homeodomain-like domain; Region: HTH_32; pfam13565
702113009326	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
702113009327	Integrase core domain; Region: rve; pfam00665
702113009328	Integrase core domain; Region: rve_3; cl15866
702113009329	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
702113009330	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113009331	active site
702113009332	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
702113009333	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113009334	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113009335	Tannase and feruloyl esterase; Region: Tannase; pfam07519
702113009336	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113009337	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113009338	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113009339	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113009340	active site
702113009341	metal binding site [ion binding]; metal-binding site
702113009342	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113009343	active site
702113009344	metal binding site [ion binding]; metal-binding site
702113009345	hypothetical protein; Provisional; Region: PRK06847
702113009346	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113009347	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
702113009348	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113009349	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113009350	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113009351	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113009352	fumarylacetoacetase; Region: PLN02856
702113009353	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
702113009354	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113009355	active site
702113009356	Amidohydrolase; Region: Amidohydro_2; pfam04909
702113009357	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113009358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113009359	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
702113009360	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
702113009361	Bacterial sugar transferase; Region: Bac_transf; pfam02397
702113009362	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113009363	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
702113009364	Peptidase S8 family domain in Protein convertases; Region: Peptidases_S8_Protein_convertases_Kexins_Furin-lik; cd04059
702113009365	calcium binding site 1 [ion binding]; other site
702113009366	active site
702113009367	catalytic triad [active]
702113009368	calcium binding site 3 [ion binding]; other site
702113009369	calcium binding site 2 [ion binding]; other site
702113009370	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
702113009371	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
702113009372	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
702113009373	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113009374	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
702113009375	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
702113009376	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
702113009377	SLBB domain; Region: SLBB; pfam10531
702113009378	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113009379	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
702113009380	putative ADP-binding pocket [chemical binding]; other site
702113009381	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
702113009382	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113009383	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
702113009384	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
702113009385	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113009386	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113009387	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
702113009388	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
702113009389	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
702113009390	Walker A/P-loop; other site
702113009391	ATP binding site [chemical binding]; other site
702113009392	Q-loop/lid; other site
702113009393	ABC transporter signature motif; other site
702113009394	Walker B; other site
702113009395	D-loop; other site
702113009396	H-loop/switch region; other site
702113009397	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
702113009398	putative catalytic site [active]
702113009399	putative metal binding site [ion binding]; other site
702113009400	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
702113009401	putative phosphate binding site [ion binding]; other site
702113009402	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
702113009403	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
702113009404	active site
702113009405	substrate binding site [chemical binding]; other site
702113009406	trimer interface [polypeptide binding]; other site
702113009407	CoA binding site [chemical binding]; other site
702113009408	PilZ domain; Region: PilZ; pfam07238
702113009409	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
702113009410	ferrochelatase; Reviewed; Region: hemH; PRK00035
702113009411	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
702113009412	active site
702113009413	C-terminal domain interface [polypeptide binding]; other site
702113009414	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
702113009415	active site
702113009416	N-terminal domain interface [polypeptide binding]; other site
702113009417	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113009418	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161
702113009419	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113009420	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
702113009421	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
702113009422	Walker A motif; other site
702113009423	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
702113009424	HflK protein; Region: hflK; TIGR01933
702113009425	HflC protein; Region: hflC; TIGR01932
702113009426	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
702113009427	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
702113009428	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
702113009429	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
702113009430	protein binding site [polypeptide binding]; other site
702113009431	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
702113009432	protein binding site [polypeptide binding]; other site
702113009433	Transglycosylase; Region: Transgly; pfam00912
702113009434	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
702113009435	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
702113009436	methionine sulfoxide reductase B; Provisional; Region: PRK00222
702113009437	SelR domain; Region: SelR; pfam01641
702113009438	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
702113009439	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
702113009440	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
702113009441	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
702113009442	Putative phosphatase (DUF442); Region: DUF442; cl17385
702113009443	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113009444	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113009445	metal binding site [ion binding]; metal-binding site
702113009446	active site
702113009447	I-site; other site
702113009448	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113009449	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
702113009450	dimer interface [polypeptide binding]; other site
702113009451	putative metal binding site [ion binding]; other site
702113009452	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
702113009453	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
702113009454	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
702113009455	putative active site [active]
702113009456	putative substrate binding site [chemical binding]; other site
702113009457	putative cosubstrate binding site; other site
702113009458	catalytic site [active]
702113009459	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
702113009460	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
702113009461	FMN binding site [chemical binding]; other site
702113009462	substrate binding site [chemical binding]; other site
702113009463	putative catalytic residue [active]
702113009464	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
702113009465	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
702113009466	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
702113009467	aspartate kinase; Reviewed; Region: PRK06635
702113009468	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
702113009469	putative nucleotide binding site [chemical binding]; other site
702113009470	putative catalytic residues [active]
702113009471	putative Mg ion binding site [ion binding]; other site
702113009472	putative aspartate binding site [chemical binding]; other site
702113009473	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
702113009474	putative allosteric regulatory site; other site
702113009475	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
702113009476	putative allosteric regulatory residue; other site
702113009477	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
702113009478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113009479	S-adenosylmethionine binding site [chemical binding]; other site
702113009480	ArsC family; Region: ArsC; pfam03960
702113009481	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
702113009482	putative catalytic residues [active]
702113009483	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
702113009484	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
702113009485	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
702113009486	Tetramer interface [polypeptide binding]; other site
702113009487	active site
702113009488	FMN-binding site [chemical binding]; other site
702113009489	peroxiredoxin; Region: AhpC; TIGR03137
702113009490	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
702113009491	dimer interface [polypeptide binding]; other site
702113009492	decamer (pentamer of dimers) interface [polypeptide binding]; other site
702113009493	catalytic triad [active]
702113009494	peroxidatic and resolving cysteines [active]
702113009495	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
702113009496	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
702113009497	catalytic residue [active]
702113009498	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
702113009499	catalytic residues [active]
702113009500	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113009501	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113009502	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
702113009503	Smr domain; Region: Smr; pfam01713
702113009504	MltA specific insert domain; Region: MltA; smart00925
702113009505	3D domain; Region: 3D; pfam06725
702113009506	Tim44-like domain; Region: Tim44; pfam04280
702113009507	Preprotein translocase subunit SecB; Region: SecB; pfam02556
702113009508	SecA binding site; other site
702113009509	Preprotein binding site; other site
702113009510	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
702113009511	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
702113009512	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
702113009513	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
702113009514	active site
702113009515	HIGH motif; other site
702113009516	dimer interface [polypeptide binding]; other site
702113009517	KMSKS motif; other site
702113009518	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
702113009519	MOSC domain; Region: MOSC; pfam03473
702113009520	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
702113009521	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
702113009522	trimer interface [polypeptide binding]; other site
702113009523	active site
702113009524	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
702113009525	Flavoprotein; Region: Flavoprotein; pfam02441
702113009526	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
702113009527	ABC1 family; Region: ABC1; cl17513
702113009528	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
702113009529	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
702113009530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113009531	S-adenosylmethionine binding site [chemical binding]; other site
702113009532	EamA-like transporter family; Region: EamA; pfam00892
702113009533	EamA-like transporter family; Region: EamA; cl17759
702113009534	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
702113009535	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
702113009536	DNA binding site [nucleotide binding]
702113009537	catalytic residue [active]
702113009538	H2TH interface [polypeptide binding]; other site
702113009539	putative catalytic residues [active]
702113009540	turnover-facilitating residue; other site
702113009541	intercalation triad [nucleotide binding]; other site
702113009542	8OG recognition residue [nucleotide binding]; other site
702113009543	putative reading head residues; other site
702113009544	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
702113009545	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
702113009546	DnaA N-terminal domain; Region: DnaA_N; pfam11638
702113009547	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
702113009548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113009549	Walker A motif; other site
702113009550	ATP binding site [chemical binding]; other site
702113009551	Walker B motif; other site
702113009552	arginine finger; other site
702113009553	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
702113009554	DnaA box-binding interface [nucleotide binding]; other site
702113009555	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113009556	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113009557	metal binding site [ion binding]; metal-binding site
702113009558	active site
702113009559	I-site; other site
702113009560	Protein of unknown function (DUF983); Region: DUF983; cl02211
702113009561	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
702113009562	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
702113009563	ATP binding site [chemical binding]; other site
702113009564	substrate interface [chemical binding]; other site
702113009565	NAD-dependent deacetylase; Provisional; Region: PRK00481
702113009566	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
702113009567	NAD+ binding site [chemical binding]; other site
702113009568	substrate binding site [chemical binding]; other site
702113009569	Zn binding site [ion binding]; other site
702113009570	dihydrodipicolinate reductase; Provisional; Region: PRK00048
702113009571	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
702113009572	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
702113009573	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
702113009574	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
702113009575	minor groove reading motif; other site
702113009576	helix-hairpin-helix signature motif; other site
702113009577	substrate binding pocket [chemical binding]; other site
702113009578	active site
702113009579	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
702113009580	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
702113009581	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
702113009582	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
702113009583	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
702113009584	metal binding site [ion binding]; metal-binding site
702113009585	dimer interface [polypeptide binding]; other site
702113009586	Cupin domain; Region: Cupin_2; cl17218
702113009587	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
702113009588	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
702113009589	putative C-terminal domain interface [polypeptide binding]; other site
702113009590	putative GSH binding site (G-site) [chemical binding]; other site
702113009591	putative dimer interface [polypeptide binding]; other site
702113009592	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
702113009593	putative N-terminal domain interface [polypeptide binding]; other site
702113009594	putative dimer interface [polypeptide binding]; other site
702113009595	putative substrate binding pocket (H-site) [chemical binding]; other site
702113009596	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
702113009597	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
702113009598	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
702113009599	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
702113009600	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
702113009601	G1 box; other site
702113009602	GTP/Mg2+ binding site [chemical binding]; other site
702113009603	Switch I region; other site
702113009604	G2 box; other site
702113009605	G3 box; other site
702113009606	Switch II region; other site
702113009607	G4 box; other site
702113009608	G5 box; other site
702113009609	membrane protein insertase; Provisional; Region: PRK01318
702113009610	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
702113009611	Ribonuclease P; Region: Ribonuclease_P; pfam00825
702113009612	Predicted periplasmic protein [Function unknown]; Region: COG3904
702113009613	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
702113009614	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
702113009615	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113009616	Walker A motif; other site
702113009617	ATP binding site [chemical binding]; other site
702113009618	Walker B motif; other site
702113009619	arginine finger; other site
702113009620	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
702113009621	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113009622	PGAP1-like protein; Region: PGAP1; pfam07819
702113009623	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
702113009624	excinuclease ABC subunit B; Provisional; Region: PRK05298
702113009625	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
702113009626	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113009627	ATP-binding site [chemical binding]; other site
702113009628	ATP binding site [chemical binding]; other site
702113009629	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113009630	nucleotide binding region [chemical binding]; other site
702113009631	ATP-binding site [chemical binding]; other site
702113009632	Ultra-violet resistance protein B; Region: UvrB; pfam12344
702113009633	UvrB/uvrC motif; Region: UVR; pfam02151
702113009634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113009635	Histidine kinase; Region: HisKA_2; pfam07568
702113009636	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113009637	ATP binding site [chemical binding]; other site
702113009638	Mg2+ binding site [ion binding]; other site
702113009639	G-X-G motif; other site
702113009640	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
702113009641	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
702113009642	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
702113009643	Uncharacterized conserved protein [Function unknown]; Region: COG3743
702113009644	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
702113009645	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113009646	ligand binding site [chemical binding]; other site
702113009647	von Willebrand factor; Region: vWF_A; pfam12450
702113009648	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
702113009649	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
702113009650	metal ion-dependent adhesion site (MIDAS); other site
702113009651	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
702113009652	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
702113009653	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
702113009654	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
702113009655	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
702113009656	UGMP family protein; Validated; Region: PRK09604
702113009657	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
702113009658	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
702113009659	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
702113009660	domain interfaces; other site
702113009661	active site
702113009662	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
702113009663	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
702113009664	active site
702113009665	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
702113009666	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113009667	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
702113009668	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
702113009669	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
702113009670	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
702113009671	DsbD alpha interface [polypeptide binding]; other site
702113009672	catalytic residues [active]
702113009673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113009674	PAS domain; Region: PAS_9; pfam13426
702113009675	putative active site [active]
702113009676	heme pocket [chemical binding]; other site
702113009677	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113009678	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113009679	metal binding site [ion binding]; metal-binding site
702113009680	active site
702113009681	I-site; other site
702113009682	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113009683	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
702113009684	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113009685	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
702113009686	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113009687	DNA binding residues [nucleotide binding]
702113009688	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
702113009689	FHIPEP family; Region: FHIPEP; pfam00771
702113009690	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113009691	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113009692	catalytic residue [active]
702113009693	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
702113009694	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
702113009695	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
702113009696	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
702113009697	flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395
702113009698	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
702113009699	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
702113009700	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
702113009701	flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506
702113009702	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
702113009703	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
702113009704	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
702113009705	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
702113009706	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
702113009707	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
702113009708	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
702113009709	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
702113009710	Flagellar L-ring protein; Region: FlgH; pfam02107
702113009711	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
702113009712	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
702113009713	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
702113009714	Rod binding protein; Region: Rod-binding; cl01626
702113009715	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
702113009716	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
702113009717	flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550
702113009718	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
702113009719	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
702113009720	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
702113009721	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
702113009722	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113009723	ligand binding site [chemical binding]; other site
702113009724	flagellin; Provisional; Region: PRK12802
702113009725	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
702113009726	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
702113009727	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
702113009728	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113009729	Walker A motif; other site
702113009730	ATP binding site [chemical binding]; other site
702113009731	Walker B motif; other site
702113009732	arginine finger; other site
702113009733	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
702113009734	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
702113009735	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
702113009736	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
702113009737	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
702113009738	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
702113009739	FliG C-terminal domain; Region: FliG_C; pfam01706
702113009740	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
702113009741	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113009742	Walker A motif; other site
702113009743	ATP binding site [chemical binding]; other site
702113009744	Walker B motif; other site
702113009745	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
702113009746	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
702113009747	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
702113009748	flagellar motor switch protein FliN; Region: fliN; TIGR02480
702113009749	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
702113009750	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
702113009751	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
702113009752	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
702113009753	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
702113009754	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
702113009755	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
702113009756	Flagellar protein FliS; Region: FliS; cl00654
702113009757	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
702113009758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
702113009759	active site
702113009760	dimerization interface [polypeptide binding]; other site
702113009761	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113009762	dimerization interface [polypeptide binding]; other site
702113009763	DNA binding residues [nucleotide binding]
702113009764	aspartate aminotransferase; Provisional; Region: PRK05764
702113009765	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113009766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113009767	homodimer interface [polypeptide binding]; other site
702113009768	catalytic residue [active]
702113009769	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
702113009770	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
702113009771	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
702113009772	putative homodimer interface [polypeptide binding]; other site
702113009773	putative homotetramer interface [polypeptide binding]; other site
702113009774	putative metal binding site [ion binding]; other site
702113009775	putative homodimer-homodimer interface [polypeptide binding]; other site
702113009776	putative allosteric switch controlling residues; other site
702113009777	CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918
702113009778	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
702113009779	ligand binding site [chemical binding]; other site
702113009780	flexible hinge region; other site
702113009781	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
702113009782	putative switch regulator; other site
702113009783	non-specific DNA interactions [nucleotide binding]; other site
702113009784	DNA binding site [nucleotide binding]
702113009785	sequence specific DNA binding site [nucleotide binding]; other site
702113009786	putative cAMP binding site [chemical binding]; other site
702113009787	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
702113009788	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
702113009789	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
702113009790	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
702113009791	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
702113009792	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
702113009793	Walker A/P-loop; other site
702113009794	ATP binding site [chemical binding]; other site
702113009795	Q-loop/lid; other site
702113009796	ABC transporter signature motif; other site
702113009797	Walker B; other site
702113009798	D-loop; other site
702113009799	H-loop/switch region; other site
702113009800	peptidase PmbA; Provisional; Region: PRK11040
702113009801	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
702113009802	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
702113009803	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113009804	active site
702113009805	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
702113009806	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
702113009807	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
702113009808	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113009809	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
702113009810	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113009811	substrate binding site [chemical binding]; other site
702113009812	oxyanion hole (OAH) forming residues; other site
702113009813	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113009814	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
702113009815	dimer interface [polypeptide binding]; other site
702113009816	active site
702113009817	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
702113009818	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
702113009819	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
702113009820	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
702113009821	acyl-activating enzyme (AAE) consensus motif; other site
702113009822	putative AMP binding site [chemical binding]; other site
702113009823	putative active site [active]
702113009824	putative CoA binding site [chemical binding]; other site
702113009825	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
702113009826	DNA binding residues [nucleotide binding]
702113009827	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
702113009828	putative dimer interface [polypeptide binding]; other site
702113009829	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
702113009830	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
702113009831	active site
702113009832	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
702113009833	catalytic triad [active]
702113009834	dimer interface [polypeptide binding]; other site
702113009835	Uncharacterized conserved protein [Function unknown]; Region: COG1262
702113009836	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
702113009837	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
702113009838	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
702113009839	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113009840	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113009841	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113009842	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
702113009843	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113009844	GMP synthase; Reviewed; Region: guaA; PRK00074
702113009845	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
702113009846	AMP/PPi binding site [chemical binding]; other site
702113009847	candidate oxyanion hole; other site
702113009848	catalytic triad [active]
702113009849	potential glutamine specificity residues [chemical binding]; other site
702113009850	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
702113009851	ATP Binding subdomain [chemical binding]; other site
702113009852	Ligand Binding sites [chemical binding]; other site
702113009853	Dimerization subdomain; other site
702113009854	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
702113009855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113009856	Mg2+ binding site [ion binding]; other site
702113009857	G-X-G motif; other site
702113009858	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
702113009859	anchoring element; other site
702113009860	dimer interface [polypeptide binding]; other site
702113009861	ATP binding site [chemical binding]; other site
702113009862	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
702113009863	active site
702113009864	putative metal-binding site [ion binding]; other site
702113009865	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
702113009866	leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411
702113009867	Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599
702113009868	active site
702113009869	Zn binding site [ion binding]; other site
702113009870	Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127
702113009871	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
702113009872	PII uridylyl-transferase; Provisional; Region: PRK05092
702113009873	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
702113009874	metal binding triad; other site
702113009875	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
702113009876	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
702113009877	Zn2+ binding site [ion binding]; other site
702113009878	Mg2+ binding site [ion binding]; other site
702113009879	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
702113009880	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
702113009881	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
702113009882	Uncharacterized conserved protein [Function unknown]; Region: COG1565
702113009883	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
702113009884	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
702113009885	putative active site [active]
702113009886	putative metal binding site [ion binding]; other site
702113009887	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
702113009888	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
702113009889	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
702113009890	Patatin phospholipase; Region: DUF3734; pfam12536
702113009891	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
702113009892	classical (c) SDRs; Region: SDR_c; cd05233
702113009893	NAD(P) binding site [chemical binding]; other site
702113009894	active site
702113009895	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
702113009896	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
702113009897	active site
702113009898	HIGH motif; other site
702113009899	nucleotide binding site [chemical binding]; other site
702113009900	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
702113009901	active site
702113009902	KMSKS motif; other site
702113009903	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
702113009904	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298
702113009905	putative NAD(P) binding site [chemical binding]; other site
702113009906	putative substrate binding site [chemical binding]; other site
702113009907	catalytic Zn binding site [ion binding]; other site
702113009908	structural Zn binding site [ion binding]; other site
702113009909	NAD synthetase; Provisional; Region: PRK13981
702113009910	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
702113009911	multimer interface [polypeptide binding]; other site
702113009912	active site
702113009913	catalytic triad [active]
702113009914	protein interface 1 [polypeptide binding]; other site
702113009915	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
702113009916	homodimer interface [polypeptide binding]; other site
702113009917	NAD binding pocket [chemical binding]; other site
702113009918	ATP binding pocket [chemical binding]; other site
702113009919	Mg binding site [ion binding]; other site
702113009920	active-site loop [active]
702113009921	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113009922	dimerization interface [polypeptide binding]; other site
702113009923	putative DNA binding site [nucleotide binding]; other site
702113009924	putative Zn2+ binding site [ion binding]; other site
702113009925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113009926	S-adenosylmethionine binding site [chemical binding]; other site
702113009927	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
702113009928	FAD binding site [chemical binding]; other site
702113009929	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
702113009930	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
702113009931	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
702113009932	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
702113009933	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
702113009934	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
702113009935	substrate binding pocket [chemical binding]; other site
702113009936	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
702113009937	B12 binding site [chemical binding]; other site
702113009938	cobalt ligand [ion binding]; other site
702113009939	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
702113009940	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
702113009941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113009942	ATP binding site [chemical binding]; other site
702113009943	putative Mg++ binding site [ion binding]; other site
702113009944	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113009945	nucleotide binding region [chemical binding]; other site
702113009946	ATP-binding site [chemical binding]; other site
702113009947	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
702113009948	HRDC domain; Region: HRDC; pfam00570
702113009949	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113009950	EamA-like transporter family; Region: EamA; pfam00892
702113009951	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113009952	aconitate hydratase; Validated; Region: PRK09277
702113009953	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
702113009954	substrate binding site [chemical binding]; other site
702113009955	ligand binding site [chemical binding]; other site
702113009956	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
702113009957	substrate binding site [chemical binding]; other site
702113009958	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
702113009959	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113009960	Walker A motif; other site
702113009961	ATP binding site [chemical binding]; other site
702113009962	Walker B motif; other site
702113009963	arginine finger; other site
702113009964	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
702113009965	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
702113009966	RuvA N terminal domain; Region: RuvA_N; pfam01330
702113009967	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
702113009968	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
702113009969	Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751
702113009970	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
702113009971	active site
702113009972	putative DNA-binding cleft [nucleotide binding]; other site
702113009973	dimer interface [polypeptide binding]; other site
702113009974	hypothetical protein; Validated; Region: PRK00110
702113009975	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
702113009976	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
702113009977	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
702113009978	pyruvate kinase; Provisional; Region: PRK06247
702113009979	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
702113009980	domain interfaces; other site
702113009981	active site
702113009982	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
702113009983	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
702113009984	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113009985	catalytic residue [active]
702113009986	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
702113009987	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
702113009988	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
702113009989	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
702113009990	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
702113009991	TrkA-N domain; Region: TrkA_N; pfam02254
702113009992	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113009993	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
702113009994	AsnC family; Region: AsnC_trans_reg; pfam01037
702113009995	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
702113009996	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
702113009997	hexamer interface [polypeptide binding]; other site
702113009998	ligand binding site [chemical binding]; other site
702113009999	putative active site [active]
702113010000	NAD(P) binding site [chemical binding]; other site
702113010001	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
702113010002	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113010003	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113010004	metal binding site [ion binding]; metal-binding site
702113010005	active site
702113010006	I-site; other site
702113010007	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
702113010008	active site
702113010009	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
702113010010	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113010011	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113010012	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113010013	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113010014	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
702113010015	active site
702113010016	Cupin domain; Region: Cupin_2; cl17218
702113010017	EF-hand domain pair; Region: EF_hand_5; pfam13499
702113010018	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
702113010019	Ca2+ binding site [ion binding]; other site
702113010020	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
702113010021	EF-hand domain pair; Region: EF_hand_5; pfam13499
702113010022	Ca2+ binding site [ion binding]; other site
702113010023	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113010024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010025	active site
702113010026	phosphorylation site [posttranslational modification]
702113010027	intermolecular recognition site; other site
702113010028	dimerization interface [polypeptide binding]; other site
702113010029	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113010030	DNA binding site [nucleotide binding]
702113010031	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
702113010032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
702113010033	dimer interface [polypeptide binding]; other site
702113010034	phosphorylation site [posttranslational modification]
702113010035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113010036	ATP binding site [chemical binding]; other site
702113010037	Mg2+ binding site [ion binding]; other site
702113010038	G-X-G motif; other site
702113010039	AAA-like domain; Region: AAA_10; pfam12846
702113010040	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
702113010041	aminodeoxychorismate synthase; Provisional; Region: PRK07508
702113010042	chorismate binding enzyme; Region: Chorismate_bind; cl10555
702113010043	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
702113010044	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
702113010045	substrate-cofactor binding pocket; other site
702113010046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010047	catalytic residue [active]
702113010048	aspartate aminotransferase; Provisional; Region: PRK05764
702113010049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113010050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010051	homodimer interface [polypeptide binding]; other site
702113010052	catalytic residue [active]
702113010053	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
702113010054	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
702113010055	active site
702113010056	hypothetical protein; Provisional; Region: PRK09256
702113010057	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
702113010058	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
702113010059	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
702113010060	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
702113010061	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
702113010062	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
702113010063	Protein of unknown function, DUF482; Region: DUF482; pfam04339
702113010064	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
702113010065	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
702113010066	active site
702113010067	catalytic site [active]
702113010068	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
702113010069	homotrimer interaction site [polypeptide binding]; other site
702113010070	putative active site [active]
702113010071	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113010072	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010073	active site
702113010074	phosphorylation site [posttranslational modification]
702113010075	intermolecular recognition site; other site
702113010076	dimerization interface [polypeptide binding]; other site
702113010077	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
702113010078	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
702113010079	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
702113010080	substrate-cofactor binding pocket; other site
702113010081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010082	catalytic residue [active]
702113010083	Predicted flavoprotein [General function prediction only]; Region: COG0431
702113010084	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
702113010085	Usg-like family; Region: Usg; pfam06233
702113010086	Predicted membrane protein [Function unknown]; Region: COG1238
702113010087	Uncharacterized conserved protein [Function unknown]; Region: COG5323
702113010088	Terminase-like family; Region: Terminase_6; pfam03237
702113010089	Phage-related protein [Function unknown]; Region: COG4695
702113010090	Phage portal protein; Region: Phage_portal; pfam04860
702113010091	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
702113010092	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
702113010093	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
702113010094	Phage capsid family; Region: Phage_capsid; pfam05065
702113010095	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
702113010096	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
702113010097	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
702113010098	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
702113010099	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
702113010100	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
702113010101	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
702113010102	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
702113010103	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
702113010104	Putative phage tail protein; Region: Phage-tail_3; pfam13550
702113010105	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
702113010106	outer membrane protein A; Reviewed; Region: PRK10808
702113010107	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
702113010108	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113010109	ligand binding site [chemical binding]; other site
702113010110	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
702113010111	Ligand Binding Site [chemical binding]; other site
702113010112	Protein of unknown function (DUF3617); Region: DUF3617; pfam12276
702113010113	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
702113010114	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
702113010115	dimerization interface [polypeptide binding]; other site
702113010116	domain crossover interface; other site
702113010117	redox-dependent activation switch; other site
702113010118	ornithine carbamoyltransferase; Provisional; Region: PRK00779
702113010119	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
702113010120	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
702113010121	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
702113010122	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
702113010123	inhibitor-cofactor binding pocket; inhibition site
702113010124	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010125	catalytic residue [active]
702113010126	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
702113010127	DNA-binding site [nucleotide binding]; DNA binding site
702113010128	RNA-binding motif; other site
702113010129	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
702113010130	DNA-binding site [nucleotide binding]; DNA binding site
702113010131	RNA-binding motif; other site
702113010132	Putative phosphatase (DUF442); Region: DUF442; cl17385
702113010133	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
702113010134	Nitrogen regulatory protein P-II; Region: P-II; smart00938
702113010135	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
702113010136	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
702113010137	Nitrogen regulatory protein P-II; Region: P-II; smart00938
702113010138	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
702113010139	putative catalytic site [active]
702113010140	putative metal binding site [ion binding]; other site
702113010141	putative phosphate binding site [ion binding]; other site
702113010142	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
702113010143	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
702113010144	G1 box; other site
702113010145	putative GEF interaction site [polypeptide binding]; other site
702113010146	GTP/Mg2+ binding site [chemical binding]; other site
702113010147	Switch I region; other site
702113010148	G2 box; other site
702113010149	G3 box; other site
702113010150	Switch II region; other site
702113010151	G4 box; other site
702113010152	G5 box; other site
702113010153	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
702113010154	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
702113010155	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
702113010156	putative NAD(P) binding site [chemical binding]; other site
702113010157	homotetramer interface [polypeptide binding]; other site
702113010158	homodimer interface [polypeptide binding]; other site
702113010159	active site
702113010160	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
702113010161	active site
702113010162	catalytic residues [active]
702113010163	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
702113010164	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
702113010165	putative tRNA-binding site [nucleotide binding]; other site
702113010166	B3/4 domain; Region: B3_4; pfam03483
702113010167	tRNA synthetase B5 domain; Region: B5; smart00874
702113010168	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
702113010169	dimer interface [polypeptide binding]; other site
702113010170	motif 1; other site
702113010171	motif 3; other site
702113010172	motif 2; other site
702113010173	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
702113010174	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
702113010175	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
702113010176	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
702113010177	dimer interface [polypeptide binding]; other site
702113010178	motif 1; other site
702113010179	active site
702113010180	motif 2; other site
702113010181	motif 3; other site
702113010182	Helix-turn-helix domain; Region: HTH_18; pfam12833
702113010183	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113010184	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
702113010185	23S rRNA binding site [nucleotide binding]; other site
702113010186	L21 binding site [polypeptide binding]; other site
702113010187	L13 binding site [polypeptide binding]; other site
702113010188	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
702113010189	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
702113010190	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
702113010191	active site
702113010192	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113010193	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
702113010194	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
702113010195	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113010196	active site
702113010197	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
702113010198	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
702113010199	putative active site [active]
702113010200	homoserine dehydrogenase; Provisional; Region: PRK06349
702113010201	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
702113010202	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
702113010203	Gram-negative bacterial tonB protein; Region: TonB; cl10048
702113010204	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
702113010205	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
702113010206	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
702113010207	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
702113010208	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
702113010209	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
702113010210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
702113010211	ATP binding site [chemical binding]; other site
702113010212	putative Mg++ binding site [ion binding]; other site
702113010213	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113010214	nucleotide binding region [chemical binding]; other site
702113010215	ATP-binding site [chemical binding]; other site
702113010216	DEAD/H associated; Region: DEAD_assoc; pfam08494
702113010217	Predicted membrane protein [Function unknown]; Region: COG3174
702113010218	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
702113010219	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
702113010220	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
702113010221	active site
702113010222	substrate binding site [chemical binding]; other site
702113010223	metal binding site [ion binding]; metal-binding site
702113010224	ATPase MipZ; Region: MipZ; pfam09140
702113010225	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113010226	P-loop; other site
702113010227	Magnesium ion binding site [ion binding]; other site
702113010228	pantoate--beta-alanine ligase; Region: panC; TIGR00018
702113010229	Pantoate-beta-alanine ligase; Region: PanC; cd00560
702113010230	active site
702113010231	ATP-binding site [chemical binding]; other site
702113010232	pantoate-binding site; other site
702113010233	HXXH motif; other site
702113010234	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
702113010235	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
702113010236	Predicted membrane protein [Function unknown]; Region: COG3503
702113010237	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113010238	homotrimer interaction site [polypeptide binding]; other site
702113010239	putative active site [active]
702113010240	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
702113010241	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
702113010242	dimer interface [polypeptide binding]; other site
702113010243	active site
702113010244	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
702113010245	substrate binding site [chemical binding]; other site
702113010246	catalytic residue [active]
702113010247	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113010248	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113010249	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
702113010250	putative effector binding pocket; other site
702113010251	putative dimerization interface [polypeptide binding]; other site
702113010252	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (23S ribosomal RNA)
702113010253	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113010254	potential protein location (putative uncharacterized protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113010255	potential protein location (conserved hypothetical protein [Novosphingobium sp. PP1Y]) that overlaps RNA (16S ribosomal RNA)
702113010256	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
702113010257	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
702113010258	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
702113010259	active site
702113010260	Zn binding site [ion binding]; other site
702113010261	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
702113010262	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
702113010263	Ligand binding site; other site
702113010264	DXD motif; other site
702113010265	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
702113010266	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
702113010267	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
702113010268	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113010269	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010270	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010271	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010272	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113010273	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
702113010274	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
702113010275	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113010276	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113010277	DNA binding site [nucleotide binding]
702113010278	domain linker motif; other site
702113010279	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
702113010280	putative dimerization interface [polypeptide binding]; other site
702113010281	putative ligand binding site [chemical binding]; other site
702113010282	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
702113010283	PHP domain; Region: PHP; pfam02811
702113010284	Secretin and TonB N terminus short domain; Region: STN; smart00965
702113010285	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113010286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010287	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010288	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113010289	FecR protein; Region: FecR; pfam04773
702113010290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113010291	RNA polymerase sigma factor; Reviewed; Region: PRK12527
702113010292	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
702113010293	DNA binding residues [nucleotide binding]
702113010294	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113010295	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113010296	DNA binding site [nucleotide binding]
702113010297	domain linker motif; other site
702113010298	Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295
702113010299	putative dimerization interface [polypeptide binding]; other site
702113010300	putative ligand binding site [chemical binding]; other site
702113010301	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113010302	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010303	putative substrate translocation pore; other site
702113010304	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010305	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010306	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010307	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
702113010308	active site
702113010309	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
702113010310	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
702113010311	AAA domain; Region: AAA_22; pfam13401
702113010312	AAA ATPase domain; Region: AAA_16; pfam13191
702113010313	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113010314	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113010315	DNA binding residues [nucleotide binding]
702113010316	dimerization interface [polypeptide binding]; other site
702113010317	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113010318	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113010319	[2Fe-2S] cluster binding site [ion binding]; other site
702113010320	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
702113010321	hydrophobic ligand binding site; other site
702113010322	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113010323	classical (c) SDRs; Region: SDR_c; cd05233
702113010324	NAD(P) binding site [chemical binding]; other site
702113010325	active site
702113010326	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
702113010327	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010328	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010329	N-terminal plug; other site
702113010330	ligand-binding site [chemical binding]; other site
702113010331	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
702113010332	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113010333	DNA binding residues [nucleotide binding]
702113010334	dimerization interface [polypeptide binding]; other site
702113010335	enoyl-CoA hydratase; Provisional; Region: PRK05862
702113010336	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113010337	substrate binding site [chemical binding]; other site
702113010338	oxyanion hole (OAH) forming residues; other site
702113010339	trimer interface [polypeptide binding]; other site
702113010340	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
702113010341	active site
702113010342	catalytic residues [active]
702113010343	DNA binding site [nucleotide binding]
702113010344	Int/Topo IB signature motif; other site
702113010345	Helix-turn-helix domain; Region: HTH_17; pfam12728
702113010346	Helix-turn-helix domain; Region: HTH_36; pfam13730
702113010347	Predicted helicase [General function prediction only]; Region: COG4889
702113010348	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
702113010349	helicase 45; Provisional; Region: PTZ00424
702113010350	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
702113010351	ATP binding site [chemical binding]; other site
702113010352	Mg++ binding site [ion binding]; other site
702113010353	motif III; other site
702113010354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
702113010355	nucleotide binding region [chemical binding]; other site
702113010356	ATP-binding site [chemical binding]; other site
702113010357	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113010358	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
702113010359	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
702113010360	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010361	H+ Antiporter protein; Region: 2A0121; TIGR00900
702113010362	putative substrate translocation pore; other site
702113010363	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
702113010364	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
702113010365	23S rRNA interface [nucleotide binding]; other site
702113010366	L3 interface [polypeptide binding]; other site
702113010367	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
702113010368	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
702113010369	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
702113010370	MerC mercury resistance protein; Region: MerC; cl03934
702113010371	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
702113010372	thiS-thiF/thiG interaction site; other site
702113010373	bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840
702113010374	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
702113010375	ThiS interaction site; other site
702113010376	putative active site [active]
702113010377	tetramer interface [polypeptide binding]; other site
702113010378	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
702113010379	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
702113010380	substrate binding pocket [chemical binding]; other site
702113010381	Ion channel; Region: Ion_trans_2; pfam07885
702113010382	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
702113010383	membrane-bound complex binding site; other site
702113010384	hinge residues; other site
702113010385	calcium/proton exchanger; Region: caca2; TIGR00846
702113010386	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
702113010387	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
702113010388	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
702113010389	acyl-activating enzyme (AAE) consensus motif; other site
702113010390	putative AMP binding site [chemical binding]; other site
702113010391	putative active site [active]
702113010392	putative CoA binding site [chemical binding]; other site
702113010393	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
702113010394	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
702113010395	active site
702113010396	catalytic residues [active]
702113010397	FMN binding site [chemical binding]; other site
702113010398	quinone interaction residues [chemical binding]; other site
702113010399	substrate binding site [chemical binding]; other site
702113010400	Rrf2 family protein; Region: rrf2_super; TIGR00738
702113010401	Transcriptional regulator; Region: Rrf2; pfam02082
702113010402	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
702113010403	putative ABC transporter; Region: ycf24; CHL00085
702113010404	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
702113010405	putative active site [active]
702113010406	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
702113010407	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
702113010408	Walker A/P-loop; other site
702113010409	ATP binding site [chemical binding]; other site
702113010410	Q-loop/lid; other site
702113010411	ABC transporter signature motif; other site
702113010412	Walker B; other site
702113010413	D-loop; other site
702113010414	H-loop/switch region; other site
702113010415	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
702113010416	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
702113010417	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
702113010418	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
702113010419	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113010420	catalytic residue [active]
702113010421	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
702113010422	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113010423	Coenzyme A binding pocket [chemical binding]; other site
702113010424	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
702113010425	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
702113010426	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
702113010427	substrate binding site [chemical binding]; other site
702113010428	ATP binding site [chemical binding]; other site
702113010429	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
702113010430	active site
702113010431	catalytic site [active]
702113010432	substrate binding site [chemical binding]; other site
702113010433	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
702113010434	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
702113010435	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
702113010436	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
702113010437	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
702113010438	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
702113010439	generic binding surface II; other site
702113010440	generic binding surface I; other site
702113010441	Uncharacterized protein conserved in bacteria (DUF2093); Region: DUF2093; pfam09866
702113010442	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
702113010443	Peptidase family M23; Region: Peptidase_M23; pfam01551
702113010444	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
702113010445	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
702113010446	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
702113010447	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
702113010448	nucleoside/Zn binding site; other site
702113010449	dimer interface [polypeptide binding]; other site
702113010450	catalytic motif [active]
702113010451	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
702113010452	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
702113010453	dimerization interface [polypeptide binding]; other site
702113010454	active site
702113010455	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
702113010456	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010457	active site
702113010458	phosphorylation site [posttranslational modification]
702113010459	intermolecular recognition site; other site
702113010460	dimerization interface [polypeptide binding]; other site
702113010461	LytTr DNA-binding domain; Region: LytTR; smart00850
702113010462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113010463	Histidine kinase; Region: His_kinase; pfam06580
702113010464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113010465	ATP binding site [chemical binding]; other site
702113010466	Mg2+ binding site [ion binding]; other site
702113010467	G-X-G motif; other site
702113010468	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
702113010469	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
702113010470	catalytic residues [active]
702113010471	Peptidase family M48; Region: Peptidase_M48; cl12018
702113010472	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113010473	binding surface
702113010474	TPR motif; other site
702113010475	TPR repeat; Region: TPR_11; pfam13414
702113010476	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113010477	TPR motif; other site
702113010478	binding surface
702113010479	Predicted transcriptional regulators [Transcription]; Region: COG1695
702113010480	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113010481	putative Zn2+ binding site [ion binding]; other site
702113010482	putative DNA binding site [nucleotide binding]; other site
702113010483	Predicted membrane protein [Function unknown]; Region: COG4709
702113010484	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
702113010485	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
702113010486	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
702113010487	putative active site [active]
702113010488	putative metal binding site [ion binding]; other site
702113010489	TIGR04168 family protein; Region: TIGR04168
702113010490	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
702113010491	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
702113010492	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
702113010493	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
702113010494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010495	active site
702113010496	phosphorylation site [posttranslational modification]
702113010497	intermolecular recognition site; other site
702113010498	dimerization interface [polypeptide binding]; other site
702113010499	LytTr DNA-binding domain; Region: LytTR; smart00850
702113010500	Histidine kinase; Region: His_kinase; pfam06580
702113010501	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113010502	ATP binding site [chemical binding]; other site
702113010503	Mg2+ binding site [ion binding]; other site
702113010504	G-X-G motif; other site
702113010505	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
702113010506	Fumarase C-terminus; Region: Fumerase_C; pfam05683
702113010507	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
702113010508	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
702113010509	Protein of unknown function (DUF2497); Region: DUF2497; pfam10691
702113010510	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
702113010511	dimer interface [polypeptide binding]; other site
702113010512	[2Fe-2S] cluster binding site [ion binding]; other site
702113010513	FOG: CBS domain [General function prediction only]; Region: COG0517
702113010514	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
702113010515	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
702113010516	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
702113010517	putative catalytic site [active]
702113010518	putative phosphate binding site [ion binding]; other site
702113010519	active site
702113010520	metal binding site A [ion binding]; metal-binding site
702113010521	DNA binding site [nucleotide binding]
702113010522	putative AP binding site [nucleotide binding]; other site
702113010523	putative metal binding site B [ion binding]; other site
702113010524	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
702113010525	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
702113010526	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
702113010527	CoenzymeA binding site [chemical binding]; other site
702113010528	subunit interaction site [polypeptide binding]; other site
702113010529	PHB binding site; other site
702113010530	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
702113010531	active site
702113010532	phosphorylation site [posttranslational modification]
702113010533	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
702113010534	30S subunit binding site; other site
702113010535	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
702113010536	active site
702113010537	catalytic site [active]
702113010538	substrate binding site [chemical binding]; other site
702113010539	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
702113010540	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
702113010541	CoA-binding site [chemical binding]; other site
702113010542	ATP-binding [chemical binding]; other site
702113010543	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
702113010544	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
702113010545	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
702113010546	shikimate binding site; other site
702113010547	NAD(P) binding site [chemical binding]; other site
702113010548	Maf-like protein; Region: Maf; pfam02545
702113010549	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
702113010550	active site
702113010551	dimer interface [polypeptide binding]; other site
702113010552	PEP synthetase regulatory protein; Provisional; Region: PRK05339
702113010553	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
702113010554	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
702113010555	metal binding site [ion binding]; metal-binding site
702113010556	Abi-like protein; Region: Abi_2; pfam07751
702113010557	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
702113010558	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
702113010559	ParB-like nuclease domain; Region: ParB; smart00470
702113010560	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
702113010561	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
702113010562	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
702113010563	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
702113010564	active site
702113010565	potential frameshift: common BLAST hit: gi|154244393|ref|YP_001415351.1| DNA methylase N-4/N-6 domain-containing protein
702113010566	DNA methylase; Region: N6_N4_Mtase; pfam01555
702113010567	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
702113010568	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
702113010569	DNA methylase; Region: N6_N4_Mtase; pfam01555
702113010570	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
702113010571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113010572	sequence-specific DNA binding site [nucleotide binding]; other site
702113010573	salt bridge; other site
702113010574	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
702113010575	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113010576	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
702113010577	catalytic residues [active]
702113010578	catalytic nucleophile [active]
702113010579	Presynaptic Site I dimer interface [polypeptide binding]; other site
702113010580	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
702113010581	Synaptic Flat tetramer interface [polypeptide binding]; other site
702113010582	Synaptic Site I dimer interface [polypeptide binding]; other site
702113010583	DNA binding site [nucleotide binding]
702113010584	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
702113010585	DNA-binding interface [nucleotide binding]; DNA binding site
702113010586	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
702113010587	dimer interface [polypeptide binding]; other site
702113010588	ssDNA binding site [nucleotide binding]; other site
702113010589	tetramer (dimer of dimers) interface [polypeptide binding]; other site
702113010590	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
702113010591	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113010592	P-loop; other site
702113010593	Magnesium ion binding site [ion binding]; other site
702113010594	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
702113010595	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
702113010596	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
702113010597	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113010598	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
702113010599	catalytic residues [active]
702113010600	catalytic nucleophile [active]
702113010601	Presynaptic Site I dimer interface [polypeptide binding]; other site
702113010602	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
702113010603	Synaptic Flat tetramer interface [polypeptide binding]; other site
702113010604	Synaptic Site I dimer interface [polypeptide binding]; other site
702113010605	DNA binding site [nucleotide binding]
702113010606	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
702113010607	DNA-binding interface [nucleotide binding]; DNA binding site
702113010608	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
702113010609	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
702113010610	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113010611	Walker A motif; other site
702113010612	ATP binding site [chemical binding]; other site
702113010613	Walker B motif; other site
702113010614	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
702113010615	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
702113010616	Walker A motif; other site
702113010617	hexamer interface [polypeptide binding]; other site
702113010618	ATP binding site [chemical binding]; other site
702113010619	Walker B motif; other site
702113010620	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
702113010621	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
702113010622	VirB7 interaction site; other site
702113010623	VirB8 protein; Region: VirB8; pfam04335
702113010624	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
702113010625	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
702113010626	Type IV secretion system proteins; Region: T4SS; pfam07996
702113010627	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
702113010628	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
702113010629	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
702113010630	TrbC/VIRB2 family; Region: TrbC; cl01583
702113010631	TraH_2; Region: TraH_2; cl17600
702113010632	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
702113010633	N-acetyl-D-glucosamine binding site [chemical binding]; other site
702113010634	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
702113010635	DNA-binding interface [nucleotide binding]; DNA binding site
702113010636	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
702113010637	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113010638	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113010639	DNA binding residues [nucleotide binding]
702113010640	dimerization interface [polypeptide binding]; other site
702113010641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113010642	non-specific DNA binding site [nucleotide binding]; other site
702113010643	salt bridge; other site
702113010644	sequence-specific DNA binding site [nucleotide binding]; other site
702113010645	Helix-turn-helix domain; Region: HTH_36; pfam13730
702113010646	potential frameshift: common BLAST hit: gi|114883610|ref|YP_740300.1| putative primase
702113010647	CHC2 zinc finger; Region: zf-CHC2; cl17510
702113010648	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
702113010649	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
702113010650	dimer interface [polypeptide binding]; other site
702113010651	ssDNA binding site [nucleotide binding]; other site
702113010652	tetramer (dimer of dimers) interface [polypeptide binding]; other site
702113010653	Helix-turn-helix domain; Region: HTH_28; pfam13518
702113010654	Winged helix-turn helix; Region: HTH_29; pfam13551
702113010655	Winged helix-turn helix; Region: HTH_33; pfam13592
702113010656	DDE superfamily endonuclease; Region: DDE_3; pfam13358
702113010657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
702113010658	PrpF protein; Region: PrpF; pfam04303
702113010659	Predicted acyl esterases [General function prediction only]; Region: COG2936
702113010660	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113010661	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
702113010662	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010663	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
702113010664	Integrase core domain; Region: rve; pfam00665
702113010665	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113010666	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
702113010667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010668	putative substrate translocation pore; other site
702113010669	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
702113010670	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
702113010671	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
702113010672	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010673	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010674	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010675	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113010676	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113010677	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
702113010678	putative dimerization interface [polypeptide binding]; other site
702113010679	dihydroxy-acid dehydratase; Validated; Region: PRK06131
702113010680	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113010681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113010682	NAD(P) binding site [chemical binding]; other site
702113010683	active site
702113010684	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113010685	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113010686	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113010687	dimerization interface [polypeptide binding]; other site
702113010688	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
702113010689	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
702113010690	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
702113010691	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
702113010692	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010693	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010694	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
702113010695	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010696	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113010697	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
702113010698	Domain of unknown function (DUF2172); Region: DUF2172; pfam09940
702113010699	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010700	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
702113010701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113010702	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
702113010703	substrate binding pocket [chemical binding]; other site
702113010704	dimerization interface [polypeptide binding]; other site
702113010705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010706	putative substrate translocation pore; other site
702113010707	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113010708	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113010709	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113010710	active site
702113010711	catalytic tetrad [active]
702113010712	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113010713	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113010714	active site
702113010715	catalytic tetrad [active]
702113010716	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
702113010717	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
702113010718	Transposase, Mutator family; Region: Transposase_mut; pfam00872
702113010719	Integrase core domain; Region: rve; pfam00665
702113010720	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
702113010721	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
702113010722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
702113010723	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
702113010724	Integrase core domain; Region: rve; pfam00665
702113010725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
702113010726	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
702113010727	Domain of unknown function (DUF336); Region: DUF336; cl01249
702113010728	Integrase core domain; Region: rve_3; cl15866
702113010729	DDE domain; Region: DDE_Tnp_IS240; pfam13610
702113010730	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113010731	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113010732	DNA binding site [nucleotide binding]
702113010733	domain linker motif; other site
702113010734	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113010735	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
702113010736	Cytochrome P450; Region: p450; cl12078
702113010737	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010738	D-galactonate transporter; Region: 2A0114; TIGR00893
702113010739	putative substrate translocation pore; other site
702113010740	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010742	putative substrate translocation pore; other site
702113010743	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010744	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010745	N-terminal plug; other site
702113010746	ligand-binding site [chemical binding]; other site
702113010747	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
702113010748	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
702113010749	ligand binding site [chemical binding]; other site
702113010750	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
702113010751	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
702113010752	putative active site [active]
702113010753	catalytic site [active]
702113010754	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
702113010755	putative active site [active]
702113010756	catalytic site [active]
702113010757	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
702113010758	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113010759	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
702113010760	Tannase and feruloyl esterase; Region: Tannase; pfam07519
702113010761	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010762	N-terminal plug; other site
702113010763	ligand-binding site [chemical binding]; other site
702113010764	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
702113010765	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
702113010766	putative active site [active]
702113010767	putative metal binding site [ion binding]; other site
702113010768	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
702113010769	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
702113010770	Acyltransferase family; Region: Acyl_transf_3; pfam01757
702113010771	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113010772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113010773	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
702113010774	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010775	putative substrate translocation pore; other site
702113010776	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113010777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010778	Response regulator receiver domain; Region: Response_reg; pfam00072
702113010779	active site
702113010780	phosphorylation site [posttranslational modification]
702113010781	intermolecular recognition site; other site
702113010782	dimerization interface [polypeptide binding]; other site
702113010783	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
702113010784	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
702113010785	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
702113010786	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
702113010787	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
702113010788	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
702113010789	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010790	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010791	SapC; Region: SapC; pfam07277
702113010792	Cupin-like domain; Region: Cupin_8; pfam13621
702113010793	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
702113010794	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
702113010795	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
702113010796	Predicted esterase [General function prediction only]; Region: COG0627
702113010797	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
702113010798	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
702113010799	active site
702113010800	alpha-galactosidase; Region: PLN02808; cl17638
702113010801	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
702113010802	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
702113010803	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
702113010804	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
702113010805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010806	putative substrate translocation pore; other site
702113010807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010808	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113010809	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113010810	DNA binding site [nucleotide binding]
702113010811	domain linker motif; other site
702113010812	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
702113010813	putative dimerization interface [polypeptide binding]; other site
702113010814	putative ligand binding site [chemical binding]; other site
702113010815	Domain of unknown function (DUF303); Region: DUF303; pfam03629
702113010816	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
702113010817	Domain of unknown function (DUF303); Region: DUF303; pfam03629
702113010818	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
702113010819	short chain dehydrogenase; Provisional; Region: PRK12939
702113010820	classical (c) SDRs; Region: SDR_c; cd05233
702113010821	NAD(P) binding site [chemical binding]; other site
702113010822	active site
702113010823	Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970
702113010824	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113010825	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
702113010826	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
702113010827	inhibitor binding site; inhibition site
702113010828	active site
702113010829	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
702113010830	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
702113010831	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
702113010832	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
702113010833	substrate binding site [chemical binding]; other site
702113010834	active site
702113010835	dihydroxy-acid dehydratase; Provisional; Region: PRK13017
702113010836	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
702113010837	active site
702113010838	catalytic residues [active]
702113010839	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
702113010840	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113010841	putative substrate translocation pore; other site
702113010842	Transcriptional regulators [Transcription]; Region: FadR; COG2186
702113010843	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113010844	DNA-binding site [nucleotide binding]; DNA binding site
702113010845	FCD domain; Region: FCD; pfam07729
702113010846	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
702113010847	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
702113010848	dimer interface [polypeptide binding]; other site
702113010849	NADP binding site [chemical binding]; other site
702113010850	catalytic residues [active]
702113010851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802
702113010852	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113010853	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
702113010854	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
702113010855	potential frameshift: common BLAST hit: gi|294146654|ref|YP_003559320.1| alpha-L-arabinosidase
702113010856	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
702113010857	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
702113010858	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
702113010859	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
702113010860	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
702113010861	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
702113010862	active site
702113010863	intersubunit interface [polypeptide binding]; other site
702113010864	catalytic residue [active]
702113010865	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010866	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010867	N-terminal plug; other site
702113010868	ligand-binding site [chemical binding]; other site
702113010869	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113010870	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
702113010871	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113010872	catalytic residue [active]
702113010873	RES domain; Region: RES; smart00953
702113010874	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
702113010875	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113010876	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113010877	WHG domain; Region: WHG; pfam13305
702113010878	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113010879	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010880	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113010881	N-terminal plug; other site
702113010882	ligand-binding site [chemical binding]; other site
702113010883	Dienelactone hydrolase family; Region: DLH; pfam01738
702113010884	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113010885	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
702113010886	beta-galactosidase; Region: BGL; TIGR03356
702113010887	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
702113010888	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
702113010889	active site
702113010890	putative substrate binding pocket [chemical binding]; other site
702113010891	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113010892	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
702113010893	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
702113010894	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113010895	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
702113010896	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
702113010897	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
702113010898	conserved cys residue [active]
702113010899	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113010900	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113010901	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113010902	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113010903	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113010904	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
702113010905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113010906	NAD(P) binding site [chemical binding]; other site
702113010907	active site
702113010908	Putative serine esterase (DUF676); Region: DUF676; pfam05057
702113010909	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113010910	DNA polymerase III subunit epsilon; Validated; Region: PRK06195
702113010911	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
702113010912	active site
702113010913	catalytic site [active]
702113010914	substrate binding site [chemical binding]; other site
702113010915	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038
702113010916	Protein of unknown function (DUF328); Region: DUF328; pfam03883
702113010917	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK05994
702113010918	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
702113010919	homodimer interface [polypeptide binding]; other site
702113010920	substrate-cofactor binding pocket; other site
702113010921	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010922	catalytic residue [active]
702113010923	Uncharacterized conserved protein [Function unknown]; Region: COG5649
702113010924	BCCT family transporter; Region: BCCT; pfam02028
702113010925	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
702113010926	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
702113010927	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
702113010928	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113010929	DNA-binding site [nucleotide binding]; DNA binding site
702113010930	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113010931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113010932	homodimer interface [polypeptide binding]; other site
702113010933	catalytic residue [active]
702113010934	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113010935	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113010936	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
702113010937	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
702113010938	NAD(P) binding site [chemical binding]; other site
702113010939	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113010940	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
702113010941	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
702113010942	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
702113010943	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
702113010944	classical (c) SDRs; Region: SDR_c; cd05233
702113010945	NAD(P) binding site [chemical binding]; other site
702113010946	active site
702113010947	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
702113010948	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010949	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113010950	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113010951	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113010952	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113010953	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113010954	dimerization interface [polypeptide binding]; other site
702113010955	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
702113010956	Beta-lactamase; Region: Beta-lactamase; pfam00144
702113010957	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113010958	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
702113010959	active site
702113010960	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113010961	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
702113010962	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
702113010963	homotrimer interaction site [polypeptide binding]; other site
702113010964	putative active site [active]
702113010965	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
702113010966	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
702113010967	Predicted integral membrane protein [Function unknown]; Region: COG0392
702113010968	Uncharacterized conserved protein [Function unknown]; Region: COG2898
702113010969	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
702113010970	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
702113010971	Bacterial virulence protein (VirJ); Region: VirJ; pfam06057
702113010972	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
702113010973	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
702113010974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113010975	active site
702113010976	phosphorylation site [posttranslational modification]
702113010977	intermolecular recognition site; other site
702113010978	dimerization interface [polypeptide binding]; other site
702113010979	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
702113010980	DNA binding site [nucleotide binding]
702113010981	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113010982	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113010983	dimer interface [polypeptide binding]; other site
702113010984	phosphorylation site [posttranslational modification]
702113010985	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113010986	ATP binding site [chemical binding]; other site
702113010987	Mg2+ binding site [ion binding]; other site
702113010988	G-X-G motif; other site
702113010989	FAD dependent oxidoreductase; Region: DAO; pfam01266
702113010990	hydroxyglutarate oxidase; Provisional; Region: PRK11728
702113010991	thioredoxin 2; Provisional; Region: PRK10996
702113010992	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
702113010993	catalytic residues [active]
702113010994	L-fucose transporter; Provisional; Region: PRK10133; cl17665
702113010995	glucose/galactose transporter; Region: gluP; TIGR01272
702113010996	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374
702113010997	putative active site [active]
702113010998	putative Zn binding site [ion binding]; other site
702113010999	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113011000	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
702113011001	putative ADP-binding pocket [chemical binding]; other site
702113011002	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; cl01930
702113011003	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113011004	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
702113011005	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011006	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113011007	putative DNA binding site [nucleotide binding]; other site
702113011008	putative Zn2+ binding site [ion binding]; other site
702113011009	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011010	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
702113011011	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
702113011012	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
702113011013	NAD binding site [chemical binding]; other site
702113011014	Phe binding site; other site
702113011015	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
702113011016	Mechanosensitive ion channel; Region: MS_channel; pfam00924
702113011017	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
702113011018	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
702113011019	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
702113011020	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011021	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011022	[2Fe-2S] cluster binding site [ion binding]; other site
702113011023	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113011024	putative alpha subunit interface [polypeptide binding]; other site
702113011025	putative active site [active]
702113011026	putative substrate binding site [chemical binding]; other site
702113011027	Fe binding site [ion binding]; other site
702113011028	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011029	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011030	[2Fe-2S] cluster binding site [ion binding]; other site
702113011031	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
702113011032	alpha subunit interface [polypeptide binding]; other site
702113011033	active site
702113011034	substrate binding site [chemical binding]; other site
702113011035	Fe binding site [ion binding]; other site
702113011036	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
702113011037	RNA/DNA hybrid binding site [nucleotide binding]; other site
702113011038	active site
702113011039	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011040	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011041	N-terminal plug; other site
702113011042	ligand-binding site [chemical binding]; other site
702113011043	PhoD-like phosphatase; Region: PhoD; pfam09423
702113011044	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
702113011045	putative active site [active]
702113011046	putative metal binding site [ion binding]; other site
702113011047	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
702113011048	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113011049	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011050	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011051	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
702113011052	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
702113011053	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
702113011054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113011055	putative PBP binding loops; other site
702113011056	ABC-ATPase subunit interface; other site
702113011057	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
702113011058	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
702113011059	Walker A/P-loop; other site
702113011060	ATP binding site [chemical binding]; other site
702113011061	Q-loop/lid; other site
702113011062	ABC transporter signature motif; other site
702113011063	Walker B; other site
702113011064	D-loop; other site
702113011065	H-loop/switch region; other site
702113011066	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
702113011067	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
702113011068	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
702113011069	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
702113011070	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
702113011071	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
702113011072	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
702113011073	urea carboxylase; Region: urea_carbox; TIGR02712
702113011074	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
702113011075	ATP-grasp domain; Region: ATP-grasp_4; cl17255
702113011076	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
702113011077	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
702113011078	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
702113011079	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
702113011080	carboxyltransferase (CT) interaction site; other site
702113011081	biotinylation site [posttranslational modification]; other site
702113011082	allophanate hydrolase; Provisional; Region: PRK08186
702113011083	Amidase; Region: Amidase; cl11426
702113011084	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777
702113011085	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
702113011086	Tetratricopeptide repeat; Region: TPR_16; pfam13432
702113011087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113011088	binding surface
702113011089	TPR motif; other site
702113011090	TPR repeat; Region: TPR_11; pfam13414
702113011091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113011092	TPR motif; other site
702113011093	binding surface
702113011094	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113011095	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
702113011096	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113011097	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113011098	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113011099	dimerization interface [polypeptide binding]; other site
702113011100	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
702113011101	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
702113011102	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
702113011103	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113011104	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
702113011105	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
702113011106	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113011107	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113011108	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011109	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
702113011110	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113011111	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113011112	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
702113011113	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
702113011114	GAF domain; Region: GAF_3; pfam13492
702113011115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113011116	dimer interface [polypeptide binding]; other site
702113011117	phosphorylation site [posttranslational modification]
702113011118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113011119	ATP binding site [chemical binding]; other site
702113011120	Mg2+ binding site [ion binding]; other site
702113011121	G-X-G motif; other site
702113011122	Response regulator receiver domain; Region: Response_reg; pfam00072
702113011123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011124	active site
702113011125	phosphorylation site [posttranslational modification]
702113011126	intermolecular recognition site; other site
702113011127	dimerization interface [polypeptide binding]; other site
702113011128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011129	Response regulator receiver domain; Region: Response_reg; pfam00072
702113011130	active site
702113011131	phosphorylation site [posttranslational modification]
702113011132	intermolecular recognition site; other site
702113011133	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113011134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011135	active site
702113011136	phosphorylation site [posttranslational modification]
702113011137	intermolecular recognition site; other site
702113011138	dimerization interface [polypeptide binding]; other site
702113011139	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
702113011140	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
702113011141	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
702113011142	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113011143	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011144	active site
702113011145	phosphorylation site [posttranslational modification]
702113011146	intermolecular recognition site; other site
702113011147	dimerization interface [polypeptide binding]; other site
702113011148	PAS domain S-box; Region: sensory_box; TIGR00229
702113011149	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113011150	HWE histidine kinase; Region: HWE_HK; smart00911
702113011151	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113011152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011153	active site
702113011154	phosphorylation site [posttranslational modification]
702113011155	intermolecular recognition site; other site
702113011156	dimerization interface [polypeptide binding]; other site
702113011157	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
702113011158	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
702113011159	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
702113011160	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113011161	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113011162	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113011163	PAS domain; Region: PAS_9; pfam13426
702113011164	putative active site [active]
702113011165	heme pocket [chemical binding]; other site
702113011166	CheB methylesterase; Region: CheB_methylest; pfam01339
702113011167	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
702113011168	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
702113011169	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
702113011170	PAS domain; Region: PAS_10; pfam13596
702113011171	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113011172	putative active site [active]
702113011173	heme pocket [chemical binding]; other site
702113011174	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113011175	HWE histidine kinase; Region: HWE_HK; smart00911
702113011176	Response regulator receiver domain; Region: Response_reg; pfam00072
702113011177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011178	active site
702113011179	phosphorylation site [posttranslational modification]
702113011180	intermolecular recognition site; other site
702113011181	dimerization interface [polypeptide binding]; other site
702113011182	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
702113011183	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
702113011184	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
702113011185	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
702113011186	salt bridge; other site
702113011187	non-specific DNA binding site [nucleotide binding]; other site
702113011188	sequence-specific DNA binding site [nucleotide binding]; other site
702113011189	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011190	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011191	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
702113011192	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
702113011193	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
702113011194	active site
702113011195	putative substrate binding pocket [chemical binding]; other site
702113011196	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113011197	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
702113011198	CoenzymeA binding site [chemical binding]; other site
702113011199	subunit interaction site [polypeptide binding]; other site
702113011200	PHB binding site; other site
702113011201	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
702113011202	CoenzymeA binding site [chemical binding]; other site
702113011203	subunit interaction site [polypeptide binding]; other site
702113011204	PHB binding site; other site
702113011205	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011206	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011207	active site
702113011208	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011209	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011210	active site
702113011211	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011212	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
702113011213	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011214	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011215	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113011216	putative DNA binding site [nucleotide binding]; other site
702113011217	putative Zn2+ binding site [ion binding]; other site
702113011218	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011219	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
702113011220	classical (c) SDRs; Region: SDR_c; cd05233
702113011221	NAD(P) binding site [chemical binding]; other site
702113011222	active site
702113011223	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
702113011224	Amidase; Region: Amidase; cl11426
702113011225	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011226	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011227	[2Fe-2S] cluster binding site [ion binding]; other site
702113011228	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011229	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113011230	NAD(P) binding site [chemical binding]; other site
702113011231	active site
702113011232	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113011233	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
702113011234	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113011235	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
702113011236	acyl-activating enzyme (AAE) consensus motif; other site
702113011237	acyl-activating enzyme (AAE) consensus motif; other site
702113011238	putative AMP binding site [chemical binding]; other site
702113011239	putative active site [active]
702113011240	putative CoA binding site [chemical binding]; other site
702113011241	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113011242	classical (c) SDRs; Region: SDR_c; cd05233
702113011243	NAD(P) binding site [chemical binding]; other site
702113011244	active site
702113011245	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
702113011246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011247	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
702113011248	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113011249	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
702113011250	acyl-activating enzyme (AAE) consensus motif; other site
702113011251	acyl-activating enzyme (AAE) consensus motif; other site
702113011252	putative AMP binding site [chemical binding]; other site
702113011253	putative active site [active]
702113011254	putative CoA binding site [chemical binding]; other site
702113011255	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
702113011256	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113011257	dimer interface [polypeptide binding]; other site
702113011258	active site
702113011259	ketosteroid isomerase: Many biological reactions proceed by enzymatic cleavage of a C-H bond adjacent to carbonyl or a carboxyl group, leading to an enol or a enolate intermediate that is subsequently re-protonated at the same or an adjacent carbon; Region: ketosteroid_isomerase; cd00781
702113011260	dimer interface [polypeptide binding]; other site
702113011261	active site/substrate binding site [active]
702113011262	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
702113011263	putative active site [active]
702113011264	putative catalytic site [active]
702113011265	short chain dehydrogenase; Provisional; Region: PRK07831
702113011266	classical (c) SDRs; Region: SDR_c; cd05233
702113011267	NAD(P) binding site [chemical binding]; other site
702113011268	active site
702113011269	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
702113011270	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011271	active site
702113011272	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011273	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113011274	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
702113011275	active site
702113011276	short chain dehydrogenase; Provisional; Region: PRK07791
702113011277	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011278	NAD(P) binding site [chemical binding]; other site
702113011279	active site
702113011280	acetyl-CoA acetyltransferase; Provisional; Region: PRK07801
702113011281	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113011282	dimer interface [polypeptide binding]; other site
702113011283	active site
702113011284	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
702113011285	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011286	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011287	active site
702113011288	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011289	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
702113011290	FAD binding site [chemical binding]; other site
702113011291	substrate binding site [chemical binding]; other site
702113011292	catalytic base [active]
702113011293	enoyl-CoA hydratase; Provisional; Region: PRK06495
702113011294	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113011295	substrate binding site [chemical binding]; other site
702113011296	oxyanion hole (OAH) forming residues; other site
702113011297	trimer interface [polypeptide binding]; other site
702113011298	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
702113011299	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
702113011300	FMN binding site [chemical binding]; other site
702113011301	substrate binding site [chemical binding]; other site
702113011302	putative catalytic residue [active]
702113011303	enoyl-CoA hydratase; Provisional; Region: PRK08290
702113011304	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113011305	substrate binding site [chemical binding]; other site
702113011306	oxyanion hole (OAH) forming residues; other site
702113011307	trimer interface [polypeptide binding]; other site
702113011308	Coenzyme A transferase; Region: CoA_trans; cl17247
702113011309	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
702113011310	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113011311	N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252
702113011312	C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237
702113011313	active site
702113011314	Fe binding site [ion binding]; other site
702113011315	short chain dehydrogenase; Provisional; Region: PRK07856
702113011316	classical (c) SDRs; Region: SDR_c; cd05233
702113011317	NAD(P) binding site [chemical binding]; other site
702113011318	active site
702113011319	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011320	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011321	active site
702113011322	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343
702113011323	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
702113011324	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
702113011325	acetaldehyde dehydrogenase; Validated; Region: PRK08300
702113011326	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
702113011327	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
702113011328	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
702113011329	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
702113011330	active site
702113011331	catalytic residues [active]
702113011332	metal binding site [ion binding]; metal-binding site
702113011333	DmpG-like communication domain; Region: DmpG_comm; pfam07836
702113011334	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
702113011335	Predicted flavoprotein [General function prediction only]; Region: COG0431
702113011336	hypothetical protein; Validated; Region: PRK07121
702113011337	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113011338	short chain dehydrogenase; Provisional; Region: PRK07890
702113011339	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011340	NAD(P) binding site [chemical binding]; other site
702113011341	active site
702113011342	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
702113011343	putative hydrophobic ligand binding site [chemical binding]; other site
702113011344	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113011345	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113011346	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113011347	active site
702113011348	catalytic tetrad [active]
702113011349	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113011350	phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287
702113011351	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
702113011352	putative trimer interface [polypeptide binding]; other site
702113011353	putative CoA binding site [chemical binding]; other site
702113011354	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113011355	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011356	classical (c) SDRs; Region: SDR_c; cd05233
702113011357	NAD(P) binding site [chemical binding]; other site
702113011358	active site
702113011359	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011360	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011361	N-terminal plug; other site
702113011362	ligand-binding site [chemical binding]; other site
702113011363	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113011364	hypothetical protein; Validated; Region: PRK07121
702113011365	choline dehydrogenase; Validated; Region: PRK02106
702113011366	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113011367	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
702113011368	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
702113011369	NAD(P) binding site [chemical binding]; other site
702113011370	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113011371	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011372	classical (c) SDRs; Region: SDR_c; cd05233
702113011373	NAD(P) binding site [chemical binding]; other site
702113011374	active site
702113011375	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113011376	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113011377	EthD domain; Region: EthD; pfam07110
702113011378	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011379	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011380	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
702113011381	classical (c) SDRs; Region: SDR_c; cd05233
702113011382	NAD(P) binding site [chemical binding]; other site
702113011383	active site
702113011384	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011385	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113011386	iron-sulfur cluster [ion binding]; other site
702113011387	[2Fe-2S] cluster binding site [ion binding]; other site
702113011388	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113011389	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113011390	LysR substrate binding domain; Region: LysR_substrate; pfam03466
702113011391	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844
702113011392	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113011393	classical (c) SDRs; Region: SDR_c; cd05233
702113011394	NAD(P) binding site [chemical binding]; other site
702113011395	active site
702113011396	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113011397	classical (c) SDRs; Region: SDR_c; cd05233
702113011398	NAD(P) binding site [chemical binding]; other site
702113011399	active site
702113011400	EthD domain; Region: EthD; pfam07110
702113011401	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
702113011402	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011403	NAD(P) binding site [chemical binding]; other site
702113011404	active site
702113011405	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113011406	active site
702113011407	metal binding site [ion binding]; metal-binding site
702113011408	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
702113011409	Cytochrome P450; Region: p450; cl12078
702113011410	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
702113011411	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
702113011412	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011413	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011414	NAD(P) binding site [chemical binding]; other site
702113011415	active site
702113011416	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011417	classical (c) SDRs; Region: SDR_c; cd05233
702113011418	NAD(P) binding site [chemical binding]; other site
702113011419	active site
702113011420	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113011421	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113011422	classical (c) SDRs; Region: SDR_c; cd05233
702113011423	NAD(P) binding site [chemical binding]; other site
702113011424	active site
702113011425	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113011426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011427	active site
702113011428	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
702113011429	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
702113011430	substrate binding pocket [chemical binding]; other site
702113011431	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113011432	short chain dehydrogenase; Provisional; Region: PRK06172
702113011433	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011434	NAD(P) binding site [chemical binding]; other site
702113011435	active site
702113011436	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113011437	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
702113011438	FMN binding site [chemical binding]; other site
702113011439	active site
702113011440	substrate binding site [chemical binding]; other site
702113011441	catalytic residue [active]
702113011442	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113011443	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
702113011444	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113011445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113011446	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113011447	classical (c) SDRs; Region: SDR_c; cd05233
702113011448	NAD(P) binding site [chemical binding]; other site
702113011449	active site
702113011450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011451	NAD(P) binding site [chemical binding]; other site
702113011452	active site
702113011453	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113011454	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011455	N-terminal plug; other site
702113011456	ligand-binding site [chemical binding]; other site
702113011457	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
702113011458	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011459	Survival protein SurE; Region: SurE; pfam01975
702113011460	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011461	classical (c) SDRs; Region: SDR_c; cd05233
702113011462	NAD(P) binding site [chemical binding]; other site
702113011463	active site
702113011464	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
702113011465	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
702113011466	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
702113011467	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
702113011468	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
702113011469	DNA binding residues [nucleotide binding]
702113011470	dimerization interface [polypeptide binding]; other site
702113011471	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011472	classical (c) SDRs; Region: SDR_c; cd05233
702113011473	NAD(P) binding site [chemical binding]; other site
702113011474	active site
702113011475	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113011476	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
702113011477	active site
702113011478	FMN binding site [chemical binding]; other site
702113011479	substrate binding site [chemical binding]; other site
702113011480	putative catalytic residue [active]
702113011481	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
702113011482	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113011483	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113011484	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011485	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113011486	putative DNA binding site [nucleotide binding]; other site
702113011487	putative Zn2+ binding site [ion binding]; other site
702113011488	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011489	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011490	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
702113011491	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011492	Transcriptional regulators [Transcription]; Region: FadR; COG2186
702113011493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113011494	DNA-binding site [nucleotide binding]; DNA binding site
702113011495	FCD domain; Region: FCD; pfam07729
702113011496	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
702113011497	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011498	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011499	putative deaminase; Validated; Region: PRK06846
702113011500	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
702113011501	active site
702113011502	PAS domain; Region: PAS_9; pfam13426
702113011503	PAS fold; Region: PAS_4; pfam08448
702113011504	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
702113011505	HWE histidine kinase; Region: HWE_HK; pfam07536
702113011506	Protein of unknown function, DUF481; Region: DUF481; cl01213
702113011507	Double zinc ribbon; Region: DZR; pfam12773
702113011508	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011509	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011510	N-terminal plug; other site
702113011511	ligand-binding site [chemical binding]; other site
702113011512	ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443
702113011513	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
702113011514	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664
702113011515	metal binding site [ion binding]; metal-binding site
702113011516	putative dimer interface [polypeptide binding]; other site
702113011517	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011518	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011519	Integrase core domain; Region: rve; pfam00665
702113011520	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
702113011521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
702113011522	Walker A motif; other site
702113011523	ATP binding site [chemical binding]; other site
702113011524	Walker B motif; other site
702113011525	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011526	Secretin and TonB N terminus short domain; Region: STN; smart00965
702113011527	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011528	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011529	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
702113011530	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113011531	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113011532	DNA binding residues [nucleotide binding]
702113011533	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113011534	FecR protein; Region: FecR; pfam04773
702113011535	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
702113011536	potential protein location (conserved hypothetical protein) that overlaps protein (hypothetical protein)
702113011537	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113011538	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011539	N-terminal plug; other site
702113011540	ligand-binding site [chemical binding]; other site
702113011541	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
702113011542	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
702113011543	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
702113011544	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
702113011545	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
702113011546	putative ligand binding site [chemical binding]; other site
702113011547	NAD binding site [chemical binding]; other site
702113011548	dimerization interface [polypeptide binding]; other site
702113011549	catalytic site [active]
702113011550	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
702113011551	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
702113011552	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
702113011553	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
702113011554	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
702113011555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113011556	dimer interface [polypeptide binding]; other site
702113011557	conserved gate region; other site
702113011558	putative PBP binding loops; other site
702113011559	ABC-ATPase subunit interface; other site
702113011560	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
702113011561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
702113011562	dimer interface [polypeptide binding]; other site
702113011563	conserved gate region; other site
702113011564	ABC-ATPase subunit interface; other site
702113011565	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
702113011566	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
702113011567	Walker A/P-loop; other site
702113011568	ATP binding site [chemical binding]; other site
702113011569	Q-loop/lid; other site
702113011570	ABC transporter signature motif; other site
702113011571	Walker B; other site
702113011572	D-loop; other site
702113011573	H-loop/switch region; other site
702113011574	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
702113011575	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
702113011576	Walker A/P-loop; other site
702113011577	ATP binding site [chemical binding]; other site
702113011578	Q-loop/lid; other site
702113011579	ABC transporter signature motif; other site
702113011580	Walker B; other site
702113011581	D-loop; other site
702113011582	H-loop/switch region; other site
702113011583	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
702113011584	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113011585	Coenzyme A binding pocket [chemical binding]; other site
702113011586	succinic semialdehyde dehydrogenase; Region: PLN02278
702113011587	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
702113011588	tetramerization interface [polypeptide binding]; other site
702113011589	NAD(P) binding site [chemical binding]; other site
702113011590	catalytic residues [active]
702113011591	tartrate dehydrogenase; Region: TTC; TIGR02089
702113011592	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
702113011593	hypothetical protein; Provisional; Region: PRK05965
702113011594	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
702113011595	inhibitor-cofactor binding pocket; inhibition site
702113011596	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113011597	catalytic residue [active]
702113011598	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113011599	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113011600	putative DNA binding site [nucleotide binding]; other site
702113011601	putative Zn2+ binding site [ion binding]; other site
702113011602	AsnC family; Region: AsnC_trans_reg; pfam01037
702113011603	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
702113011604	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
702113011605	metal binding site [ion binding]; metal-binding site
702113011606	putative dimer interface [polypeptide binding]; other site
702113011607	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
702113011608	CopC domain; Region: CopC; pfam04234
702113011609	Copper resistance protein D; Region: CopD; cl00563
702113011610	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
702113011611	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
702113011612	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
702113011613	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
702113011614	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113011615	NAD binding site [chemical binding]; other site
702113011616	catalytic residues [active]
702113011617	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113011618	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113011619	metal binding site [ion binding]; metal-binding site
702113011620	active site
702113011621	I-site; other site
702113011622	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113011623	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
702113011624	hydroxyglutarate oxidase; Provisional; Region: PRK11728
702113011625	Predicted membrane protein [Function unknown]; Region: COG3503
702113011626	Cupin domain; Region: Cupin_2; cl17218
702113011627	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
702113011628	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113011629	Putative cyclase; Region: Cyclase; pfam04199
702113011630	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113011631	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113011632	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113011633	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113011634	active site
702113011635	metal binding site [ion binding]; metal-binding site
702113011636	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
702113011637	putative active site [active]
702113011638	Mn binding site [ion binding]; other site
702113011639	putative oligomer interface [polypeptide binding]; other site
702113011640	hypothetical protein; Provisional; Region: PRK06847
702113011641	hypothetical protein; Provisional; Region: PRK07236
702113011642	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
702113011643	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113011644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011645	putative substrate translocation pore; other site
702113011646	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
702113011647	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113011648	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113011649	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
702113011650	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113011651	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
702113011652	Metal-binding active site; metal-binding site
702113011653	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
702113011654	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
702113011655	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
702113011656	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
702113011657	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011658	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113011659	putative substrate translocation pore; other site
702113011660	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
702113011661	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
702113011662	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
702113011663	Multicopper oxidase; Region: Cu-oxidase; pfam00394
702113011664	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
702113011665	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113011666	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113011667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113011668	DNA binding residues [nucleotide binding]
702113011669	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
702113011670	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011671	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011672	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113011673	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113011674	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113011675	dimerization interface [polypeptide binding]; other site
702113011676	Predicted transcriptional regulators [Transcription]; Region: COG1725
702113011677	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113011678	DNA-binding site [nucleotide binding]; DNA binding site
702113011679	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
702113011680	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113011681	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011682	N-terminal plug; other site
702113011683	ligand-binding site [chemical binding]; other site
702113011684	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113011685	Sulfatase; Region: Sulfatase; pfam00884
702113011686	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
702113011687	Carboxylesterase family; Region: COesterase; pfam00135
702113011688	substrate binding pocket [chemical binding]; other site
702113011689	catalytic triad [active]
702113011690	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113011691	Putative cyclase; Region: Cyclase; pfam04199
702113011692	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113011693	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113011694	2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213
702113011695	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113011696	active site
702113011697	metal binding site [ion binding]; metal-binding site
702113011698	C-terminal, catalytic, domain of BphC5 (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacterium Rhodococcus rhodochrous K37 and similar proteins; Region: BphC5-RK37_C_like; cd07239
702113011699	putative active site [active]
702113011700	Mn binding site [ion binding]; other site
702113011701	putative oligomer interface [polypeptide binding]; other site
702113011702	hypothetical protein; Provisional; Region: PRK06847
702113011703	hypothetical protein; Provisional; Region: PRK07236
702113011704	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
702113011705	beta-galactosidase; Region: BGL; TIGR03356
702113011706	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011707	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113011708	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113011709	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113011710	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113011711	dimerization interface [polypeptide binding]; other site
702113011712	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011713	D-galactonate transporter; Region: 2A0114; TIGR00893
702113011714	putative substrate translocation pore; other site
702113011715	beta-D-glucuronidase; Provisional; Region: PRK10150
702113011716	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
702113011717	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
702113011718	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
702113011719	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
702113011720	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
702113011721	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
702113011722	substrate binding site [chemical binding]; other site
702113011723	ATP binding site [chemical binding]; other site
702113011724	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
702113011725	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
702113011726	putative active site pocket [active]
702113011727	putative metal binding site [ion binding]; other site
702113011728	glucuronate isomerase; Reviewed; Region: PRK02925
702113011729	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
702113011730	D-mannonate oxidoreductase; Provisional; Region: PRK15037
702113011731	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
702113011732	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
702113011733	Autotransporter beta-domain; Region: Autotransporter; smart00869
702113011734	ParB-like nuclease domain; Region: ParB; smart00470
702113011735	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113011736	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
702113011737	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
702113011738	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011739	active site
702113011740	phosphorylation site [posttranslational modification]
702113011741	intermolecular recognition site; other site
702113011742	dimerization interface [polypeptide binding]; other site
702113011743	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113011744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113011745	dimer interface [polypeptide binding]; other site
702113011746	phosphorylation site [posttranslational modification]
702113011747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113011748	ATP binding site [chemical binding]; other site
702113011749	Mg2+ binding site [ion binding]; other site
702113011750	G-X-G motif; other site
702113011751	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
702113011752	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
702113011753	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
702113011754	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
702113011755	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
702113011756	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
702113011757	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
702113011758	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
702113011759	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
702113011760	ATP binding site [chemical binding]; other site
702113011761	Walker A motif; other site
702113011762	hexamer interface [polypeptide binding]; other site
702113011763	Walker B motif; other site
702113011764	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
702113011765	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
702113011766	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
702113011767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113011768	Tetratricopeptide repeat; Region: TPR_16; pfam13432
702113011769	TPR motif; other site
702113011770	binding surface
702113011771	Predicted membrane protein [Function unknown]; Region: COG4655
702113011772	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
702113011773	Flp/Fap pilin component; Region: Flp_Fap; cl01585
702113011774	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
702113011775	TadE-like protein; Region: TadE; pfam07811
702113011776	Response regulator receiver domain; Region: Response_reg; pfam00072
702113011777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113011778	active site
702113011779	phosphorylation site [posttranslational modification]
702113011780	intermolecular recognition site; other site
702113011781	dimerization interface [polypeptide binding]; other site
702113011782	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
702113011783	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
702113011784	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
702113011785	Surface antigen; Region: Bac_surface_Ag; pfam01103
702113011786	Plasmid encoded RepA protein; Region: RepA_C; pfam04796
702113011787	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
702113011788	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
702113011789	DNA binding residues [nucleotide binding]
702113011790	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
702113011791	P-loop; other site
702113011792	Magnesium ion binding site [ion binding]; other site
702113011793	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
702113011794	ParB-like nuclease domain; Region: ParBc; pfam02195
702113011795	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
702113011796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113011797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113011798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113011799	dimerization interface [polypeptide binding]; other site
702113011800	isovaleryl-CoA dehydrogenase; Region: PLN02519
702113011801	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011802	active site
702113011803	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
702113011804	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113011805	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011806	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
702113011807	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
702113011808	benzoate transport; Region: 2A0115; TIGR00895
702113011809	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011810	putative substrate translocation pore; other site
702113011811	benzoate transport; Region: 2A0115; TIGR00895
702113011812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011813	putative substrate translocation pore; other site
702113011814	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
702113011815	Uncharacterized conserved protein [Function unknown]; Region: COG1359
702113011816	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113011817	SnoaL-like domain; Region: SnoaL_3; pfam13474
702113011818	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011819	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011820	N-terminal plug; other site
702113011821	ligand-binding site [chemical binding]; other site
702113011822	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
702113011823	PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); Region: PQQ_ADH_II; cd10279
702113011824	Trp docking motif [polypeptide binding]; other site
702113011825	cytochrome domain interface [polypeptide binding]; other site
702113011826	active site
702113011827	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113011828	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113011829	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
702113011830	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
702113011831	FAD binding pocket [chemical binding]; other site
702113011832	FAD binding motif [chemical binding]; other site
702113011833	phosphate binding motif [ion binding]; other site
702113011834	NAD binding pocket [chemical binding]; other site
702113011835	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
702113011836	putative deacylase active site [active]
702113011837	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113011838	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011839	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011840	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011841	N-terminal plug; other site
702113011842	ligand-binding site [chemical binding]; other site
702113011843	TPR repeat; Region: TPR_11; pfam13414
702113011844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113011845	binding surface
702113011846	TPR motif; other site
702113011847	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; pfam13759
702113011848	Uncharacterized conserved protein [Function unknown]; Region: COG1359
702113011849	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011850	short chain dehydrogenase; Validated; Region: PRK07069
702113011851	NAD(P) binding site [chemical binding]; other site
702113011852	active site
702113011853	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
702113011854	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113011855	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113011856	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
702113011857	active site
702113011858	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
702113011859	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
702113011860	tetramer interface [polypeptide binding]; other site
702113011861	TPP-binding site [chemical binding]; other site
702113011862	heterodimer interface [polypeptide binding]; other site
702113011863	phosphorylation loop region [posttranslational modification]
702113011864	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
702113011865	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
702113011866	alpha subunit interface [polypeptide binding]; other site
702113011867	TPP binding site [chemical binding]; other site
702113011868	heterodimer interface [polypeptide binding]; other site
702113011869	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113011870	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113011871	E3 interaction surface; other site
702113011872	lipoyl attachment site [posttranslational modification]; other site
702113011873	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
702113011874	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
702113011875	Trp docking motif [polypeptide binding]; other site
702113011876	putative active site [active]
702113011877	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
702113011878	substrate binding site [chemical binding]; other site
702113011879	metal binding site [ion binding]; metal-binding site
702113011880	dimer interface [polypeptide binding]; other site
702113011881	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011882	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011883	[2Fe-2S] cluster binding site [ion binding]; other site
702113011884	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113011885	putative alpha subunit interface [polypeptide binding]; other site
702113011886	putative active site [active]
702113011887	putative substrate binding site [chemical binding]; other site
702113011888	Fe binding site [ion binding]; other site
702113011889	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011890	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011891	[2Fe-2S] cluster binding site [ion binding]; other site
702113011892	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113011893	putative alpha subunit interface [polypeptide binding]; other site
702113011894	putative active site [active]
702113011895	putative substrate binding site [chemical binding]; other site
702113011896	Fe binding site [ion binding]; other site
702113011897	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011898	short chain dehydrogenase; Validated; Region: PRK07069
702113011899	NAD(P) binding site [chemical binding]; other site
702113011900	active site
702113011901	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011903	NAD(P) binding site [chemical binding]; other site
702113011904	active site
702113011905	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113011906	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011907	AMP-binding domain protein; Validated; Region: PRK08315
702113011908	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113011909	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
702113011910	acyl-activating enzyme (AAE) consensus motif; other site
702113011911	putative AMP binding site [chemical binding]; other site
702113011912	putative active site [active]
702113011913	putative CoA binding site [chemical binding]; other site
702113011914	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113011915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011916	NAD(P) binding site [chemical binding]; other site
702113011917	active site
702113011918	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011919	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011920	[2Fe-2S] cluster binding site [ion binding]; other site
702113011921	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113011922	putative alpha subunit interface [polypeptide binding]; other site
702113011923	putative active site [active]
702113011924	putative substrate binding site [chemical binding]; other site
702113011925	Fe binding site [ion binding]; other site
702113011926	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
702113011927	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
702113011928	tetramer interface [polypeptide binding]; other site
702113011929	TPP-binding site [chemical binding]; other site
702113011930	heterodimer interface [polypeptide binding]; other site
702113011931	phosphorylation loop region [posttranslational modification]
702113011932	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
702113011933	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
702113011934	alpha subunit interface [polypeptide binding]; other site
702113011935	TPP binding site [chemical binding]; other site
702113011936	heterodimer interface [polypeptide binding]; other site
702113011937	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
702113011938	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
702113011939	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
702113011940	E3 interaction surface; other site
702113011941	lipoyl attachment site [posttranslational modification]; other site
702113011942	e3 binding domain; Region: E3_binding; pfam02817
702113011943	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
702113011944	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
702113011945	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
702113011946	active site
702113011947	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
702113011948	putative active site [active]
702113011949	putative catalytic site [active]
702113011950	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
702113011951	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
702113011952	active site
702113011953	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
702113011954	catalytic triad [active]
702113011955	dimer interface [polypeptide binding]; other site
702113011956	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113011957	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113011958	active site
702113011959	metal binding site [ion binding]; metal-binding site
702113011960	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113011961	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113011962	NAD(P) binding site [chemical binding]; other site
702113011963	active site
702113011964	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113011965	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113011966	[2Fe-2S] cluster binding site [ion binding]; other site
702113011967	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
702113011968	alpha subunit interface [polypeptide binding]; other site
702113011969	active site
702113011970	substrate binding site [chemical binding]; other site
702113011971	Fe binding site [ion binding]; other site
702113011972	OsmC-like protein; Region: OsmC; pfam02566
702113011973	Cupin; Region: Cupin_6; pfam12852
702113011974	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113011975	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113011976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113011977	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
702113011978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113011979	metabolite-proton symporter; Region: 2A0106; TIGR00883
702113011980	putative substrate translocation pore; other site
702113011981	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113011982	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113011983	N-terminal plug; other site
702113011984	ligand-binding site [chemical binding]; other site
702113011985	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113011986	Sulfatase; Region: Sulfatase; pfam00884
702113011987	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113011988	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
702113011989	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113011990	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113011991	DNA binding site [nucleotide binding]
702113011992	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113011993	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113011994	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113011995	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113011996	enoyl-CoA hydratase; Provisional; Region: PRK06494
702113011997	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113011998	substrate binding site [chemical binding]; other site
702113011999	oxyanion hole (OAH) forming residues; other site
702113012000	trimer interface [polypeptide binding]; other site
702113012001	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113012002	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669
702113012003	active site
702113012004	metal binding site [ion binding]; metal-binding site
702113012005	thiolase; Provisional; Region: PRK06158
702113012006	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
702113012007	active site
702113012008	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
702113012009	DUF35 OB-fold domain; Region: DUF35; pfam01796
702113012010	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113012011	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113012012	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012013	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012014	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
702113012015	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113012016	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
702113012017	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
702113012018	FtsX-like permease family; Region: FtsX; pfam02687
702113012019	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
702113012020	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
702113012021	Walker A/P-loop; other site
702113012022	ATP binding site [chemical binding]; other site
702113012023	Q-loop/lid; other site
702113012024	ABC transporter signature motif; other site
702113012025	Walker B; other site
702113012026	D-loop; other site
702113012027	H-loop/switch region; other site
702113012028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113012029	binding surface
702113012030	TPR motif; other site
702113012031	Protein of unknown function (DUF560); Region: DUF560; pfam04575
702113012032	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
702113012033	potential frameshift: common BLAST hit: gi|119385731|ref|YP_916786.1| TonB-dependent siderophore receptor
702113012034	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012035	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012036	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012037	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113012038	active site
702113012039	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
702113012040	Erythromycin esterase; Region: Erythro_esteras; pfam05139
702113012041	ATP synthase; Region: ATP-synt; pfam00231
702113012042	core domain interface [polypeptide binding]; other site
702113012043	delta subunit interface [polypeptide binding]; other site
702113012044	epsilon subunit interface [polypeptide binding]; other site
702113012045	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
702113012046	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
702113012047	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
702113012048	Walker A motif; other site
702113012049	ATP binding site [chemical binding]; other site
702113012050	Walker B motif; other site
702113012051	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
702113012052	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
702113012053	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
702113012054	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
702113012055	F0F1 ATP synthase subunit A; Provisional; Region: PRK13421
702113012056	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
702113012057	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
702113012058	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
702113012059	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
702113012060	alpha subunit interaction interface [polypeptide binding]; other site
702113012061	Walker A motif; other site
702113012062	ATP binding site [chemical binding]; other site
702113012063	Walker B motif; other site
702113012064	inhibitor binding site; inhibition site
702113012065	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
702113012066	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
702113012067	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113012068	Beta-Casp domain; Region: Beta-Casp; smart01027
702113012069	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
702113012070	phosphoribosylpyrophosphate synthetase; Provisional; Region: PRK07199
702113012071	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
702113012072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
702113012073	active site
702113012074	thymidine phosphorylase; Provisional; Region: PRK04350
702113012075	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
702113012076	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
702113012077	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
702113012078	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
702113012079	Uncharacterized conserved protein [Function unknown]; Region: COG2128
702113012080	EthD domain; Region: EthD; pfam07110
702113012081	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
702113012082	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113012083	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
702113012084	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
702113012085	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
702113012086	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
702113012087	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
702113012088	motif II; other site
702113012089	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
702113012090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113012091	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113012092	NAD(P) binding site [chemical binding]; other site
702113012093	active site
702113012094	histidinol dehydrogenase; Region: hisD; TIGR00069
702113012095	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
702113012096	NAD binding site [chemical binding]; other site
702113012097	dimerization interface [polypeptide binding]; other site
702113012098	product binding site; other site
702113012099	substrate binding site [chemical binding]; other site
702113012100	zinc binding site [ion binding]; other site
702113012101	catalytic residues [active]
702113012102	Cupin domain; Region: Cupin_2; pfam07883
702113012103	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113012104	Sulfatase; Region: Sulfatase; pfam00884
702113012105	Sulfatase; Region: Sulfatase; cl17466
702113012106	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012107	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012108	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
702113012109	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012110	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012111	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113012112	Sulfatase; Region: Sulfatase; pfam00884
702113012113	Protein of unknown function (DUF983); Region: DUF983; cl02211
702113012114	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
702113012115	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113012116	DNA-binding site [nucleotide binding]; DNA binding site
702113012117	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113012118	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113012119	homodimer interface [polypeptide binding]; other site
702113012120	catalytic residue [active]
702113012121	Transcriptional regulators [Transcription]; Region: MarR; COG1846
702113012122	MarR family; Region: MarR; pfam01047
702113012123	Acyltransferase family; Region: Acyl_transf_3; pfam01757
702113012124	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
702113012125	choline dehydrogenase; Validated; Region: PRK02106
702113012126	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113012127	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
702113012128	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
702113012129	Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139
702113012130	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113012131	NAD binding site [chemical binding]; other site
702113012132	catalytic residues [active]
702113012133	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113012134	Sulfatase; Region: Sulfatase; pfam00884
702113012135	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113012136	MarR family; Region: MarR_2; pfam12802
702113012137	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
702113012138	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
702113012139	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
702113012140	homodimer interface [polypeptide binding]; other site
702113012141	NADP binding site [chemical binding]; other site
702113012142	substrate binding site [chemical binding]; other site
702113012143	Dihydroneopterin aldolase; Region: FolB; smart00905
702113012144	active site
702113012145	aminodeoxychorismate synthase; Provisional; Region: PRK07508
702113012146	chorismate binding enzyme; Region: Chorismate_bind; cl10555
702113012147	transcriptional activator TtdR; Provisional; Region: PRK09801
702113012148	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012149	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
702113012150	putative effector binding pocket; other site
702113012151	dimerization interface [polypeptide binding]; other site
702113012152	amidase; Provisional; Region: PRK09201
702113012153	Amidase; Region: Amidase; pfam01425
702113012154	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
702113012155	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
702113012156	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
702113012157	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113012158	catalytic residue [active]
702113012159	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
702113012160	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
702113012161	active site
702113012162	catalytic site [active]
702113012163	tetramer interface [polypeptide binding]; other site
702113012164	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
702113012165	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
702113012166	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
702113012167	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
702113012168	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
702113012169	active site
702113012170	homotetramer interface [polypeptide binding]; other site
702113012171	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012172	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012173	xanthine permease; Region: pbuX; TIGR03173
702113012174	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012175	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012176	N-terminal plug; other site
702113012177	ligand-binding site [chemical binding]; other site
702113012178	allantoate amidohydrolase; Reviewed; Region: PRK09290
702113012179	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
702113012180	active site
702113012181	metal binding site [ion binding]; metal-binding site
702113012182	dimer interface [polypeptide binding]; other site
702113012183	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
702113012184	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
702113012185	active site
702113012186	metal binding site [ion binding]; metal-binding site
702113012187	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
702113012188	dimer interface [polypeptide binding]; other site
702113012189	tetramer interface [polypeptide binding]; other site
702113012190	active site
702113012191	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
702113012192	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
702113012193	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
702113012194	putative active site [active]
702113012195	putative substrate binding site [chemical binding]; other site
702113012196	putative cosubstrate binding site; other site
702113012197	catalytic site [active]
702113012198	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
702113012199	FAD binding site [chemical binding]; other site
702113012200	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
702113012201	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
702113012202	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
702113012203	Transcriptional regulator [Transcription]; Region: IclR; COG1414
702113012204	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
702113012205	Bacterial transcriptional regulator; Region: IclR; pfam01614
702113012206	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
702113012207	substrate binding site [chemical binding]; other site
702113012208	THF binding site; other site
702113012209	zinc-binding site [ion binding]; other site
702113012210	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113012211	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
702113012212	NAD(P) binding site [chemical binding]; other site
702113012213	catalytic residues [active]
702113012214	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
702113012215	CoA binding domain; Region: CoA_binding_2; pfam13380
702113012216	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
702113012217	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
702113012218	p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120
702113012219	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113012220	substrate binding site [chemical binding]; other site
702113012221	oxyanion hole (OAH) forming residues; other site
702113012222	trimer interface [polypeptide binding]; other site
702113012223	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113012224	active site
702113012225	metal binding site [ion binding]; metal-binding site
702113012226	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113012227	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113012228	[2Fe-2S] cluster binding site [ion binding]; other site
702113012229	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
702113012230	alpha subunit interface [polypeptide binding]; other site
702113012231	active site
702113012232	substrate binding site [chemical binding]; other site
702113012233	Fe binding site [ion binding]; other site
702113012234	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012235	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012236	N-terminal plug; other site
702113012237	ligand-binding site [chemical binding]; other site
702113012238	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012239	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012240	classical (c) SDRs; Region: SDR_c; cd05233
702113012241	NAD(P) binding site [chemical binding]; other site
702113012242	active site
702113012243	Prostaglandin dehydrogenases; Region: PGDH; cd05288
702113012244	NAD(P) binding site [chemical binding]; other site
702113012245	substrate binding site [chemical binding]; other site
702113012246	dimer interface [polypeptide binding]; other site
702113012247	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113012248	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113012249	[2Fe-2S] cluster binding site [ion binding]; other site
702113012250	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113012251	putative alpha subunit interface [polypeptide binding]; other site
702113012252	putative active site [active]
702113012253	putative substrate binding site [chemical binding]; other site
702113012254	Fe binding site [ion binding]; other site
702113012255	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113012256	DNA binding residues [nucleotide binding]
702113012257	dimerization interface [polypeptide binding]; other site
702113012258	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
702113012259	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
702113012260	phosphate binding site [ion binding]; other site
702113012261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
702113012262	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
702113012263	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
702113012264	Trehalase; Region: Trehalase; cl17346
702113012265	trehalase; Provisional; Region: treF; PRK13270
702113012266	Domain of unknown function (DUF336); Region: DUF336; cl01249
702113012267	Protein of unknown function (DUF998); Region: DUF998; pfam06197
702113012268	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
702113012269	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
702113012270	SnoaL-like domain; Region: SnoaL_2; pfam12680
702113012271	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
702113012272	putative dimer interface [polypeptide binding]; other site
702113012273	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113012274	ligand binding site [chemical binding]; other site
702113012275	Zn binding site [ion binding]; other site
702113012276	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
702113012277	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012278	LysR family transcriptional regulator; Provisional; Region: PRK14997
702113012279	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113012280	dimerization interface [polypeptide binding]; other site
702113012281	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
702113012282	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
702113012283	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
702113012284	Trp docking motif [polypeptide binding]; other site
702113012285	active site
702113012286	rod shape-determining protein MreB; Provisional; Region: PRK13927
702113012287	MreB and similar proteins; Region: MreB_like; cd10225
702113012288	nucleotide binding site [chemical binding]; other site
702113012289	Mg binding site [ion binding]; other site
702113012290	putative protofilament interaction site [polypeptide binding]; other site
702113012291	RodZ interaction site [polypeptide binding]; other site
702113012292	RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when...; Region: RhoGAP; cl02570
702113012293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
702113012294	dimerization interface [polypeptide binding]; other site
702113012295	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113012296	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113012297	metal binding site [ion binding]; metal-binding site
702113012298	active site
702113012299	I-site; other site
702113012300	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
702113012301	PhnA protein; Region: PhnA; pfam03831
702113012302	Ferritin-like domain; Region: Ferritin; pfam00210
702113012303	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
702113012304	dinuclear metal binding motif [ion binding]; other site
702113012305	Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472
702113012306	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
702113012307	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
702113012308	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
702113012309	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
702113012310	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
702113012311	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
702113012312	AMP-binding domain protein; Validated; Region: PRK08315
702113012313	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113012314	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
702113012315	acyl-activating enzyme (AAE) consensus motif; other site
702113012316	putative AMP binding site [chemical binding]; other site
702113012317	putative active site [active]
702113012318	putative CoA binding site [chemical binding]; other site
702113012319	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113012320	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
702113012321	NAD(P) binding site [chemical binding]; other site
702113012322	catalytic residues [active]
702113012323	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012324	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012325	N-terminal plug; other site
702113012326	ligand-binding site [chemical binding]; other site
702113012327	Cytochrome c; Region: Cytochrom_C; cl11414
702113012328	Cytochrome c; Region: Cytochrom_C; pfam00034
702113012329	Methylamine dehydrogenase, L chain; Region: Me-amine-dh_L; cl03812
702113012330	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
702113012331	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
702113012332	methylamine dehydrogenase (amicyanin) heavy chain; Region: TTQ_MADH_Hv; TIGR02658
702113012333	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012334	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012335	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
702113012336	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012337	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
702113012338	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012339	Transcriptional regulators [Transcription]; Region: FadR; COG2186
702113012340	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113012341	DNA-binding site [nucleotide binding]; DNA binding site
702113012342	FCD domain; Region: FCD; pfam07729
702113012343	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
702113012344	active site
702113012345	catalytic residues [active]
702113012346	metal binding site [ion binding]; metal-binding site
702113012347	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
702113012348	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
702113012349	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
702113012350	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
702113012351	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
702113012352	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113012353	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113012354	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
702113012355	Domain of unknown function (DUF1993); Region: DUF1993; pfam09351
702113012356	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
702113012357	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
702113012358	Isochorismatase family; Region: Isochorismatase; pfam00857
702113012359	catalytic triad [active]
702113012360	dimer interface [polypeptide binding]; other site
702113012361	conserved cis-peptide bond; other site
702113012362	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113012363	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113012364	TAP-like protein; Region: Abhydrolase_4; pfam08386
702113012365	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
702113012366	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
702113012367	active site
702113012368	Predicted membrane protein [Function unknown]; Region: COG2259
702113012369	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
702113012370	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
702113012371	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012372	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012373	DoxX-like family; Region: DoxX_2; pfam13564
702113012374	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113012375	Trehalose utilisation; Region: ThuA; pfam06283
702113012376	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
702113012377	MFS/sugar transport protein; Region: MFS_2; pfam13347
702113012378	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012379	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012380	N-terminal plug; other site
702113012381	ligand-binding site [chemical binding]; other site
702113012382	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
702113012383	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
702113012384	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
702113012385	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113012386	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
702113012387	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
702113012388	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012389	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012390	N-terminal plug; other site
702113012391	ligand-binding site [chemical binding]; other site
702113012392	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
702113012393	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
702113012394	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
702113012395	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113012396	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
702113012397	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
702113012398	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
702113012399	MFS/sugar transport protein; Region: MFS_2; pfam13347
702113012400	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
702113012401	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
702113012402	putative catalytic residue [active]
702113012403	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012404	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012405	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012406	Major Facilitator Superfamily; Region: MFS_1; pfam07690
702113012407	putative substrate translocation pore; other site
702113012408	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
702113012409	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
702113012410	active site
702113012411	P-loop; other site
702113012412	phosphorylation site [posttranslational modification]
702113012413	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
702113012414	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
702113012415	active site
702113012416	P-loop; other site
702113012417	phosphorylation site [posttranslational modification]
702113012418	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
702113012419	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
702113012420	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
702113012421	putative substrate binding site [chemical binding]; other site
702113012422	putative ATP binding site [chemical binding]; other site
702113012423	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
702113012424	active site
702113012425	phosphorylation site [posttranslational modification]
702113012426	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
702113012427	dimerization domain swap beta strand [polypeptide binding]; other site
702113012428	regulatory protein interface [polypeptide binding]; other site
702113012429	active site
702113012430	regulatory phosphorylation site [posttranslational modification]; other site
702113012431	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
702113012432	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
702113012433	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
702113012434	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
702113012435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113012436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113012437	DNA binding site [nucleotide binding]
702113012438	domain linker motif; other site
702113012439	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
702113012440	shikimate 5-dehydrogenase; Reviewed; Region: PRK12550
702113012441	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
702113012442	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
702113012443	shikimate binding site; other site
702113012444	NAD(P) binding site [chemical binding]; other site
702113012445	fructose-1,6-bisphosphatase family protein; Region: PLN02628
702113012446	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
702113012447	AMP binding site [chemical binding]; other site
702113012448	metal binding site [ion binding]; metal-binding site
702113012449	active site
702113012450	SnoaL-like domain; Region: SnoaL_4; pfam13577
702113012451	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
702113012452	probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619
702113012453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012455	choline dehydrogenase; Validated; Region: PRK02106
702113012456	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
702113012457	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
702113012458	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
702113012459	Predicted membrane protein [Function unknown]; Region: COG2855
702113012460	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012461	D-galactonate transporter; Region: 2A0114; TIGR00893
702113012462	putative substrate translocation pore; other site
702113012463	MASE1; Region: MASE1; cl17823
702113012464	PAS domain S-box; Region: sensory_box; TIGR00229
702113012465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
702113012466	putative active site [active]
702113012467	heme pocket [chemical binding]; other site
702113012468	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113012469	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113012470	metal binding site [ion binding]; metal-binding site
702113012471	active site
702113012472	I-site; other site
702113012473	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012474	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012475	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113012476	TPR motif; other site
702113012477	binding surface
702113012478	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
702113012479	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113012480	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113012481	DNA binding site [nucleotide binding]
702113012482	domain linker motif; other site
702113012483	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
702113012484	putative dimerization interface [polypeptide binding]; other site
702113012485	putative ligand binding site [chemical binding]; other site
702113012486	SnoaL-like domain; Region: SnoaL_3; pfam13474
702113012487	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
702113012488	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
702113012489	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
702113012490	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
702113012491	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
702113012492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113012493	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
702113012494	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113012495	DNA binding residues [nucleotide binding]
702113012496	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
702113012497	DNA-binding site [nucleotide binding]; DNA binding site
702113012498	RNA-binding motif; other site
702113012499	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
702113012500	DNA-binding site [nucleotide binding]; DNA binding site
702113012501	RNA-binding motif; other site
702113012502	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113012503	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113012504	putative DNA binding site [nucleotide binding]; other site
702113012505	putative Zn2+ binding site [ion binding]; other site
702113012506	AsnC family; Region: AsnC_trans_reg; pfam01037
702113012507	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
702113012508	Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493
702113012509	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
702113012510	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
702113012511	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
702113012512	inhibitor-cofactor binding pocket; inhibition site
702113012513	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113012514	catalytic residue [active]
702113012515	Transposase domain (DUF772); Region: DUF772; pfam05598
702113012516	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
702113012517	DDE superfamily endonuclease; Region: DDE_4; cl17710
702113012518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012519	MFS/sugar transport protein; Region: MFS_2; pfam13347
702113012520	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
702113012521	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
702113012522	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
702113012523	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012524	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012525	N-terminal plug; other site
702113012526	ligand-binding site [chemical binding]; other site
702113012527	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
702113012528	Predicted amidohydrolase [General function prediction only]; Region: COG0388
702113012529	active site
702113012530	catalytic triad [active]
702113012531	dimer interface [polypeptide binding]; other site
702113012532	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113012533	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113012534	DNA binding site [nucleotide binding]
702113012535	domain linker motif; other site
702113012536	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
702113012537	putative dimerization interface [polypeptide binding]; other site
702113012538	putative ligand binding site [chemical binding]; other site
702113012539	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
702113012540	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113012541	putative DNA binding site [nucleotide binding]; other site
702113012542	putative Zn2+ binding site [ion binding]; other site
702113012543	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113012544	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
702113012545	NAD(P) binding site [chemical binding]; other site
702113012546	catalytic residues [active]
702113012547	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
702113012548	benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229
702113012549	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113012550	iron-sulfur cluster [ion binding]; other site
702113012551	[2Fe-2S] cluster binding site [ion binding]; other site
702113012552	C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879
702113012553	putative alpha subunit interface [polypeptide binding]; other site
702113012554	putative active site [active]
702113012555	putative substrate binding site [chemical binding]; other site
702113012556	Fe binding site [ion binding]; other site
702113012557	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012558	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012559	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
702113012560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113012561	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
702113012562	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
702113012563	Predicted amidohydrolase [General function prediction only]; Region: COG0388
702113012564	putative active site [active]
702113012565	catalytic triad [active]
702113012566	putative dimer interface [polypeptide binding]; other site
702113012567	D-galactonate transporter; Region: 2A0114; TIGR00893
702113012568	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012569	putative substrate translocation pore; other site
702113012570	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
702113012571	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
702113012572	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
702113012573	acetolactate synthase catalytic subunit; Validated; Region: PRK08327
702113012574	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
702113012575	PYR/PP interface [polypeptide binding]; other site
702113012576	dimer interface [polypeptide binding]; other site
702113012577	TPP binding site [chemical binding]; other site
702113012578	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
702113012579	Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002
702113012580	TPP-binding site [chemical binding]; other site
702113012581	dimer interface [polypeptide binding]; other site
702113012582	potential frameshift: common BLAST hit: gi|293980665|ref|YP_003543423.1| putative transposase
702113012583	DDE superfamily endonuclease; Region: DDE_3; pfam13358
702113012584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
702113012585	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
702113012586	CoA binding domain; Region: CoA_binding_2; pfam13380
702113012587	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
702113012588	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
702113012589	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
702113012590	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113012591	substrate binding site [chemical binding]; other site
702113012592	oxyanion hole (OAH) forming residues; other site
702113012593	trimer interface [polypeptide binding]; other site
702113012594	metabolite-proton symporter; Region: 2A0106; TIGR00883
702113012595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012596	putative substrate translocation pore; other site
702113012597	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113012598	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
702113012599	substrate binding site [chemical binding]; other site
702113012600	oxyanion hole (OAH) forming residues; other site
702113012601	trimer interface [polypeptide binding]; other site
702113012602	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
702113012603	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113012604	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
702113012605	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
702113012606	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
702113012607	dimer interface [polypeptide binding]; other site
702113012608	active site
702113012609	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-2; cd12809
702113012610	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
702113012611	catalytic site [active]
702113012612	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
702113012613	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
702113012614	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
702113012615	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
702113012616	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
702113012617	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012618	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
702113012619	dimerization interface [polypeptide binding]; other site
702113012620	substrate binding pocket [chemical binding]; other site
702113012621	Cupin domain; Region: Cupin_2; pfam07883
702113012622	biosynthesis cluster domain; Region: biosyn_clust_1; cl14822
702113012623	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
702113012624	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
702113012625	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
702113012626	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
702113012627	dimerization interface [polypeptide binding]; other site
702113012628	putative ATP binding site [chemical binding]; other site
702113012629	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
702113012630	Coenzyme A binding pocket [chemical binding]; other site
702113012631	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
702113012632	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
702113012633	Predicted amidohydrolase [General function prediction only]; Region: COG0388
702113012634	putative active site [active]
702113012635	catalytic triad [active]
702113012636	putative dimer interface [polypeptide binding]; other site
702113012637	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
702113012638	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
702113012639	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113012640	DNA-binding site [nucleotide binding]; DNA binding site
702113012641	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113012642	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113012643	homodimer interface [polypeptide binding]; other site
702113012644	catalytic residue [active]
702113012645	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012646	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012647	N-terminal plug; other site
702113012648	ligand-binding site [chemical binding]; other site
702113012649	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012650	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
702113012651	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
702113012652	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
702113012653	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113012654	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
702113012655	catalytic residues [active]
702113012656	catalytic nucleophile [active]
702113012657	Recombinase; Region: Recombinase; pfam07508
702113012658	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
702113012659	Helix-turn-helix domain; Region: HTH_17; pfam12728
702113012660	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
702113012661	Integrase core domain; Region: rve; pfam00665
702113012662	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
702113012663	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012664	active site
702113012665	DNA binding site [nucleotide binding]
702113012666	Int/Topo IB signature motif; other site
702113012667	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
702113012668	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012669	active site
702113012670	DNA binding site [nucleotide binding]
702113012671	Int/Topo IB signature motif; other site
702113012672	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
702113012673	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012674	active site
702113012675	DNA binding site [nucleotide binding]
702113012676	Int/Topo IB signature motif; other site
702113012677	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
702113012678	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012679	active site
702113012680	DNA binding site [nucleotide binding]
702113012681	Int/Topo IB signature motif; other site
702113012682	putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293
702113012683	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
702113012684	Protein of unknown function (DUF2384); Region: DUF2384; cl17718
702113012685	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
702113012686	active site
702113012687	DNA binding site [nucleotide binding]
702113012688	Int/Topo IB signature motif; other site
702113012689	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113012690	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012691	putative substrate translocation pore; other site
702113012692	Transposase; Region: DDE_Tnp_ISL3; pfam01610
702113012693	Autoinducer binding domain; Region: Autoind_bind; pfam03472
702113012694	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113012695	DNA binding residues [nucleotide binding]
702113012696	dimerization interface [polypeptide binding]; other site
702113012697	DDE superfamily endonuclease; Region: DDE_5; cl17874
702113012698	Cytochrome c; Region: Cytochrom_C; pfam00034
702113012699	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113012700	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
702113012701	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113012702	catalytic loop [active]
702113012703	iron binding site [ion binding]; other site
702113012704	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
702113012705	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
702113012706	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113012707	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
702113012708	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113012709	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113012710	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
702113012711	putative effector binding pocket; other site
702113012712	dimerization interface [polypeptide binding]; other site
702113012713	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012714	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113012715	putative substrate translocation pore; other site
702113012716	Isochorismatase family; Region: Isochorismatase; pfam00857
702113012717	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
702113012718	catalytic triad [active]
702113012719	dimer interface [polypeptide binding]; other site
702113012720	conserved cis-peptide bond; other site
702113012721	(R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway.  The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441
702113012722	active site
702113012723	catalytic site [active]
702113012724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113012725	Putative cyclase; Region: Cyclase; pfam04199
702113012726	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113012727	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113012728	active site
702113012729	catalytic tetrad [active]
702113012730	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
702113012731	putative hydrophobic ligand binding site [chemical binding]; other site
702113012732	protein interface [polypeptide binding]; other site
702113012733	gate; other site
702113012734	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113012735	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012736	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113012737	dimerization interface [polypeptide binding]; other site
702113012738	luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571
702113012739	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
702113012740	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
702113012741	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113012742	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113012743	active site
702113012744	catalytic tetrad [active]
702113012745	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113012746	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
702113012747	FMN binding site [chemical binding]; other site
702113012748	active site
702113012749	substrate binding site [chemical binding]; other site
702113012750	catalytic residue [active]
702113012751	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113012752	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
702113012753	NAD(P) binding site [chemical binding]; other site
702113012754	active site
702113012755	hypothetical protein; Provisional; Region: PRK07236
702113012756	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
702113012757	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
702113012758	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
702113012759	catalytic residues [active]
702113012760	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113012761	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012762	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
702113012763	putative effector binding pocket; other site
702113012764	dimerization interface [polypeptide binding]; other site
702113012765	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113012766	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
702113012767	FMN binding site [chemical binding]; other site
702113012768	active site
702113012769	substrate binding site [chemical binding]; other site
702113012770	catalytic residue [active]
702113012771	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
702113012772	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113012773	D-lactate dehydrogenase; Provisional; Region: PRK11183
702113012774	FAD binding domain; Region: FAD_binding_4; pfam01565
702113012775	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
702113012776	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113012777	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
702113012778	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
702113012779	active site
702113012780	FMN binding site [chemical binding]; other site
702113012781	substrate binding site [chemical binding]; other site
702113012782	homotetramer interface [polypeptide binding]; other site
702113012783	catalytic residue [active]
702113012784	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
702113012785	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
702113012786	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
702113012787	Histidine kinase; Region: HisKA_3; pfam07730
702113012788	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113012789	ATP binding site [chemical binding]; other site
702113012790	Mg2+ binding site [ion binding]; other site
702113012791	G-X-G motif; other site
702113012792	Predicted acetyltransferase [General function prediction only]; Region: COG2388
702113012793	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
702113012794	Domain of unknown function (DUF4104); Region: DUF4104; pfam13372
702113012795	DoxX; Region: DoxX; pfam07681
702113012796	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
702113012797	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
702113012798	active site
702113012799	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
702113012800	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
702113012801	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
702113012802	TAP-like protein; Region: Abhydrolase_4; pfam08386
702113012803	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
702113012804	Isochorismatase family; Region: Isochorismatase; pfam00857
702113012805	catalytic triad [active]
702113012806	dimer interface [polypeptide binding]; other site
702113012807	conserved cis-peptide bond; other site
702113012808	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
702113012809	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113012810	active site
702113012811	phosphorylation site [posttranslational modification]
702113012812	intermolecular recognition site; other site
702113012813	dimerization interface [polypeptide binding]; other site
702113012814	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113012815	DNA binding residues [nucleotide binding]
702113012816	dimerization interface [polypeptide binding]; other site
702113012817	Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789
702113012818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
702113012819	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
702113012820	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113012821	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
702113012822	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
702113012823	dimerization interface [polypeptide binding]; other site
702113012824	DPS ferroxidase diiron center [ion binding]; other site
702113012825	ion pore; other site
702113012826	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
702113012827	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
702113012828	substrate binding pocket [chemical binding]; other site
702113012829	catalytic triad [active]
702113012830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113012831	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
702113012832	NAD(P) binding site [chemical binding]; other site
702113012833	active site
702113012834	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
702113012835	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012836	N-terminal plug; other site
702113012837	ligand-binding site [chemical binding]; other site
702113012838	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
702113012839	FAD binding domain; Region: FAD_binding_4; pfam01565
702113012840	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
702113012841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012842	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113012843	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
702113012844	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113012845	Transcriptional regulators [Transcription]; Region: FadR; COG2186
702113012846	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113012847	DNA-binding site [nucleotide binding]; DNA binding site
702113012848	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
702113012849	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113012850	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113012851	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471
702113012852	putative effector binding pocket; other site
702113012853	putative dimerization interface [polypeptide binding]; other site
702113012854	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
702113012855	classical (c) SDRs; Region: SDR_c; cd05233
702113012856	NAD(P) binding site [chemical binding]; other site
702113012857	active site
702113012858	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
702113012859	active site 1 [active]
702113012860	dimer interface [polypeptide binding]; other site
702113012861	hexamer interface [polypeptide binding]; other site
702113012862	active site 2 [active]
702113012863	Protein of unknown function (DUF3237); Region: DUF3237; pfam11578
702113012864	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
702113012865	putative dimer interface [polypeptide binding]; other site
702113012866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113012867	ligand binding site [chemical binding]; other site
702113012868	Zn binding site [ion binding]; other site
702113012869	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
702113012870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012871	putative substrate translocation pore; other site
702113012872	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113012873	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113012874	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
702113012875	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113012876	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113012877	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
702113012878	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
702113012879	putative substrate translocation pore; other site
702113012880	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
702113012881	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113012882	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113012883	active site
702113012884	catalytic tetrad [active]
702113012885	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113012886	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113012887	N-terminal plug; other site
702113012888	ligand-binding site [chemical binding]; other site
702113012889	alpha-glucosidase; Provisional; Region: PRK10426
702113012890	YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594
702113012891	putative active site [active]
702113012892	putative catalytic site [active]
702113012893	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
702113012894	Transcriptional regulators [Transcription]; Region: PurR; COG1609
702113012895	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
702113012896	DNA binding site [nucleotide binding]
702113012897	domain linker motif; other site
702113012898	Ligand-binding domain of DNA transcription repressor SalR, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_SalR; cd01545
702113012899	putative ligand binding site [chemical binding]; other site
702113012900	putative dimerization interface [polypeptide binding]; other site
702113012901	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113012902	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113012903	active site
702113012904	catalytic tetrad [active]
702113012905	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
702113012906	active site
702113012907	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
702113012908	dimer interface [polypeptide binding]; other site
702113012909	non-prolyl cis peptide bond; other site
702113012910	insertion regions; other site
702113012911	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
702113012912	hydroxyglutarate oxidase; Provisional; Region: PRK11728
702113012913	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
702113012914	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
702113012915	N- and C-terminal domain interface [polypeptide binding]; other site
702113012916	active site
702113012917	MgATP binding site [chemical binding]; other site
702113012918	catalytic site [active]
702113012919	metal binding site [ion binding]; metal-binding site
702113012920	glycerol binding site [chemical binding]; other site
702113012921	homotetramer interface [polypeptide binding]; other site
702113012922	homodimer interface [polypeptide binding]; other site
702113012923	FBP binding site [chemical binding]; other site
702113012924	protein IIAGlc interface [polypeptide binding]; other site
702113012925	Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028
702113012926	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
702113012927	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
702113012928	rRNA binding site [nucleotide binding]; other site
702113012929	predicted 30S ribosome binding site; other site
702113012930	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
702113012931	DNA-binding site [nucleotide binding]; DNA binding site
702113012932	RNA-binding motif; other site
702113012933	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
702113012934	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
702113012935	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
702113012936	TrkA-N domain; Region: TrkA_N; pfam02254
702113012937	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
702113012938	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
702113012939	ligand binding site [chemical binding]; other site
702113012940	Spore Coat Protein U domain; Region: SCPU; pfam05229
702113012941	Spore Coat Protein U domain; Region: SCPU; pfam05229
702113012942	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
702113012943	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
702113012944	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
702113012945	PapC N-terminal domain; Region: PapC_N; pfam13954
702113012946	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
702113012947	PapC C-terminal domain; Region: PapC_C; pfam13953
702113012948	Spore Coat Protein U domain; Region: SCPU; pfam05229
702113012949	Uncharacterized secreted protein [Function unknown]; Region: COG5430
702113012950	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
702113012951	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
702113012952	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
702113012953	protein binding site [polypeptide binding]; other site
702113012954	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
702113012955	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113012956	putative DNA binding site [nucleotide binding]; other site
702113012957	putative Zn2+ binding site [ion binding]; other site
702113012958	AsnC family; Region: AsnC_trans_reg; pfam01037
702113012959	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
702113012960	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
702113012961	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113012962	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113012963	Amidohydrolase; Region: Amidohydro_4; pfam13147
702113012964	active site
702113012965	amino acid transporter; Region: 2A0306; TIGR00909
702113012966	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
702113012967	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
702113012968	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
702113012969	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
702113012970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
702113012971	homodimer interface [polypeptide binding]; other site
702113012972	catalytic residue [active]
702113012973	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012974	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012975	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113012976	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
702113012977	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
702113012978	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
702113012979	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
702113012980	catalytic residue [active]
702113012981	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
702113012982	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
702113012983	cytidylate kinase; Provisional; Region: cmk; PRK00023
702113012984	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
702113012985	CMP-binding site; other site
702113012986	The sites determining sugar specificity; other site
702113012987	Rossmann-like domain; Region: Rossmann-like; pfam10727
702113012988	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
702113012989	Acyltransferase family; Region: Acyl_transf_3; pfam01757
702113012990	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
702113012991	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113012992	NAD(P) binding site [chemical binding]; other site
702113012993	active site
702113012994	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113012995	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
702113012996	active site
702113012997	metal binding site [ion binding]; metal-binding site
702113012998	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113012999	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
702113013000	[2Fe-2S] cluster binding site [ion binding]; other site
702113013001	C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882
702113013002	putative alpha subunit interface [polypeptide binding]; other site
702113013003	putative active site [active]
702113013004	putative substrate binding site [chemical binding]; other site
702113013005	Fe binding site [ion binding]; other site
702113013006	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113013007	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113013008	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
702113013009	enoyl-CoA hydratase; Provisional; Region: PRK06688
702113013010	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
702113013011	substrate binding site [chemical binding]; other site
702113013012	oxyanion hole (OAH) forming residues; other site
702113013013	trimer interface [polypeptide binding]; other site
702113013014	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113013015	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
702113013016	putative ADP-binding pocket [chemical binding]; other site
702113013017	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
702113013018	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
702113013019	Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078
702113013020	putative catalytic site [active]
702113013021	metal binding site A [ion binding]; metal-binding site
702113013022	phosphate binding site [ion binding]; other site
702113013023	metal binding site C [ion binding]; metal-binding site
702113013024	metal binding site B [ion binding]; metal-binding site
702113013025	malic enzyme; Reviewed; Region: PRK12862
702113013026	Malic enzyme, N-terminal domain; Region: malic; pfam00390
702113013027	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
702113013028	putative NAD(P) binding site [chemical binding]; other site
702113013029	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
702113013030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
702113013031	dimerization interface [polypeptide binding]; other site
702113013032	putative DNA binding site [nucleotide binding]; other site
702113013033	putative Zn2+ binding site [ion binding]; other site
702113013034	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
702113013035	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
702113013036	putative metal binding site [ion binding]; other site
702113013037	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
702113013038	Low molecular weight phosphatase family; Region: LMWPc; cd00115
702113013039	active site
702113013040	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
702113013041	Sodium Bile acid symporter family; Region: SBF; cl17470
702113013042	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
702113013043	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
702113013044	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
702113013045	rhamnose-proton symporter; Provisional; Region: PRK13499
702113013046	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
702113013047	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
702113013048	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
702113013049	phosphate binding site [ion binding]; other site
702113013050	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
702113013051	nucleotide binding site [chemical binding]; other site
702113013052	short chain dehydrogenase; Validated; Region: PRK08324
702113013053	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
702113013054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113013055	NAD(P) binding site [chemical binding]; other site
702113013056	active site
702113013057	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
702113013058	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
702113013059	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
702113013060	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
702113013061	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113013062	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113013063	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
702113013064	dimerization interface [polypeptide binding]; other site
702113013065	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
702113013066	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113013067	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
702113013068	active site
702113013069	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
702113013070	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
702113013071	Domain of unknown function (DUF336); Region: DUF336; cl01249
702113013072	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
702113013073	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113013074	active site
702113013075	metal binding site [ion binding]; metal-binding site
702113013076	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
702113013077	active site
702113013078	metal binding site [ion binding]; metal-binding site
702113013079	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
702113013080	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
702113013081	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113013082	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113013083	N-terminal plug; other site
702113013084	ligand-binding site [chemical binding]; other site
702113013085	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
702113013086	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
702113013087	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
702113013088	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
702113013089	beta-galactosidase; Region: BGL; TIGR03356
702113013090	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
702113013091	Cupin domain; Region: Cupin_2; cl17218
702113013092	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
702113013093	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
702113013094	The A subunit of Uncharacterized proteins with similarity to Protocatechuate 4,5-dioxygenase (LigAB); Region: LigA_like_1; cd07925
702113013095	putative dimer interface [polypeptide binding]; other site
702113013096	putative tetramer interface [polypeptide binding]; other site
702113013097	putative active site [active]
702113013098	Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599
702113013099	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
702113013100	active site
702113013101	metal binding site [ion binding]; metal-binding site
702113013102	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
702113013103	Cytochrome P450; Region: p450; cl12078
702113013104	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
702113013105	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
702113013106	active site
702113013107	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
702113013108	hypothetical protein; Provisional; Region: PRK09262
702113013109	hypothetical protein; Validated; Region: PRK06201
702113013110	Transcriptional regulator [Transcription]; Region: LysR; COG0583
702113013111	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113013112	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
702113013113	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
702113013114	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
702113013115	dimerization interface [polypeptide binding]; other site
702113013116	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
702113013117	Domain of unknown function (DUF1932); Region: DUF1932; pfam09130
702113013118	Amidohydrolase; Region: Amidohydro_2; pfam04909
702113013119	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
702113013120	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
702113013121	iron-sulfur cluster [ion binding]; other site
702113013122	[2Fe-2S] cluster binding site [ion binding]; other site
702113013123	C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878
702113013124	alpha subunit interface [polypeptide binding]; other site
702113013125	active site
702113013126	substrate binding site [chemical binding]; other site
702113013127	Fe binding site [ion binding]; other site
702113013128	The A subunit of Protocatechuate 4,5-dioxygenase (LigAB) is the smaller, non-catalytic subunit; Region: PCA_45_Doxase_A; cd07924
702113013129	dimer interface [polypeptide binding]; other site
702113013130	tetramer interface [polypeptide binding]; other site
702113013131	active site
702113013132	Subunit B of the Class III extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, which catalyzes the oxidization and subsequent ring-opening of protocatechuate; Region: PCA_45_Dioxygenase_B; cd07364
702113013133	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
702113013134	active site
702113013135	Fe(II) binding site [ion binding]; other site
702113013136	dimer interface [polypeptide binding]; other site
702113013137	tetramer interface [polypeptide binding]; other site
702113013138	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
702113013139	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
702113013140	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
702113013141	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
702113013142	active site
702113013143	catalytic tetrad [active]
702113013144	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
702113013145	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
702113013146	dimer interface [polypeptide binding]; other site
702113013147	active site residues [active]
702113013148	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
702113013149	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
702113013150	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
702113013151	PAS domain S-box; Region: sensory_box; TIGR00229
702113013152	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
702113013153	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113013154	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113013155	metal binding site [ion binding]; metal-binding site
702113013156	active site
702113013157	I-site; other site
702113013158	putative oxidoreductase; Provisional; Region: PRK11579
702113013159	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
702113013160	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
702113013161	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
702113013162	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
702113013163	dimer interface [polypeptide binding]; other site
702113013164	active site
702113013165	heme binding site [chemical binding]; other site
702113013166	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
702113013167	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
702113013168	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
702113013169	Walker A/P-loop; other site
702113013170	ATP binding site [chemical binding]; other site
702113013171	Q-loop/lid; other site
702113013172	ABC transporter signature motif; other site
702113013173	Walker B; other site
702113013174	D-loop; other site
702113013175	H-loop/switch region; other site
702113013176	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
702113013177	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
702113013178	Walker A/P-loop; other site
702113013179	ATP binding site [chemical binding]; other site
702113013180	Q-loop/lid; other site
702113013181	ABC transporter signature motif; other site
702113013182	Walker B; other site
702113013183	D-loop; other site
702113013184	H-loop/switch region; other site
702113013185	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
702113013186	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
702113013187	TM-ABC transporter signature motif; other site
702113013188	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
702113013189	TM-ABC transporter signature motif; other site
702113013190	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
702113013191	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
702113013192	putative ligand binding site [chemical binding]; other site
702113013193	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
702113013194	UreD urease accessory protein; Region: UreD; pfam01774
702113013195	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
702113013196	alpha-gamma subunit interface [polypeptide binding]; other site
702113013197	beta-gamma subunit interface [polypeptide binding]; other site
702113013198	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
702113013199	alpha-beta subunit interface [polypeptide binding]; other site
702113013200	urease subunit alpha; Reviewed; Region: ureC; PRK13207
702113013201	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
702113013202	subunit interactions [polypeptide binding]; other site
702113013203	active site
702113013204	flap region; other site
702113013205	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
702113013206	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
702113013207	dimer interface [polypeptide binding]; other site
702113013208	catalytic residues [active]
702113013209	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
702113013210	UreF; Region: UreF; pfam01730
702113013211	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
702113013212	G1 box; other site
702113013213	GTP/Mg2+ binding site [chemical binding]; other site
702113013214	G2 box; other site
702113013215	Switch I region; other site
702113013216	Switch II region; other site
702113013217	G4 box; other site
702113013218	G5 box; other site
702113013219	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
702113013220	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
702113013221	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
702113013222	Na binding site [ion binding]; other site
702113013223	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
702113013224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
702113013225	dimer interface [polypeptide binding]; other site
702113013226	phosphorylation site [posttranslational modification]
702113013227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
702113013228	ATP binding site [chemical binding]; other site
702113013229	Mg2+ binding site [ion binding]; other site
702113013230	G-X-G motif; other site
702113013231	Response regulator receiver domain; Region: Response_reg; pfam00072
702113013232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113013233	active site
702113013234	phosphorylation site [posttranslational modification]
702113013235	intermolecular recognition site; other site
702113013236	dimerization interface [polypeptide binding]; other site
702113013237	Response regulator receiver domain; Region: Response_reg; pfam00072
702113013238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
702113013239	active site
702113013240	phosphorylation site [posttranslational modification]
702113013241	intermolecular recognition site; other site
702113013242	dimerization interface [polypeptide binding]; other site
702113013243	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
702113013244	DNA binding residues [nucleotide binding]
702113013245	Secretin and TonB N terminus short domain; Region: STN; smart00965
702113013246	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113013247	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113013248	FecR protein; Region: FecR; pfam04773
702113013249	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113013250	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113013251	DNA binding residues [nucleotide binding]
702113013252	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113013253	S-adenosylmethionine binding site [chemical binding]; other site
702113013254	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
702113013255	binding surface
702113013256	TPR motif; other site
702113013257	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
702113013258	classical (c) SDRs; Region: SDR_c; cd05233
702113013259	NAD(P) binding site [chemical binding]; other site
702113013260	active site
702113013261	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
702113013262	acyl-activating enzyme (AAE) consensus motif; other site
702113013263	AMP binding site [chemical binding]; other site
702113013264	active site
702113013265	CoA binding site [chemical binding]; other site
702113013266	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
702113013267	heme binding pocket [chemical binding]; other site
702113013268	heme ligand [chemical binding]; other site
702113013269	Thermostable hemolysin; Region: T_hemolysin; pfam12261
702113013270	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
702113013271	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
702113013272	catalytic loop [active]
702113013273	iron binding site [ion binding]; other site
702113013274	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
702113013275	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
702113013276	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113013277	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
702113013278	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113013279	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
702113013280	Cytochrome c; Region: Cytochrom_C; pfam00034
702113013281	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113013282	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
702113013283	Cytochrome c; Region: Cytochrom_C; pfam00034
702113013284	Autotransporter beta-domain; Region: Autotransporter; cl17461
702113013285	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113013286	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113013287	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113013288	FecR protein; Region: FecR; pfam04773
702113013289	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
702113013290	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
702113013291	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
702113013292	DNA binding residues [nucleotide binding]
702113013293	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
702113013294	Sulfatase; Region: Sulfatase; pfam00884
702113013295	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
702113013296	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113013297	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
702113013298	N-terminal plug; other site
702113013299	ligand-binding site [chemical binding]; other site
702113013300	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
702113013301	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
702113013302	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
702113013303	S-adenosylmethionine binding site [chemical binding]; other site
702113013304	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
702113013305	Phosphopantetheine attachment site; Region: PP-binding; cl09936
702113013306	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
702113013307	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
702113013308	dimer interface [polypeptide binding]; other site
702113013309	active site
702113013310	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
702113013311	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
702113013312	malonyl-CoA binding site [chemical binding]; other site
702113013313	dimer interface [polypeptide binding]; other site
702113013314	active site
702113013315	product binding site; other site
702113013316	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
702113013317	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
702113013318	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
702113013319	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
702113013320	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
702113013321	catalytic residues [active]
702113013322	catalytic nucleophile [active]
702113013323	Presynaptic Site I dimer interface [polypeptide binding]; other site
702113013324	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
702113013325	Synaptic Flat tetramer interface [polypeptide binding]; other site
702113013326	Synaptic Site I dimer interface [polypeptide binding]; other site
702113013327	DNA binding site [nucleotide binding]
702113013328	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
702113013329	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
702113013330	Walker A/P-loop; other site
702113013331	ATP binding site [chemical binding]; other site
702113013332	Q-loop/lid; other site
702113013333	ABC transporter signature motif; other site
702113013334	Walker B; other site
702113013335	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
702113013336	HlyD family secretion protein; Region: HlyD_3; pfam13437
702113013337	Outer membrane efflux protein; Region: OEP; pfam02321
702113013338	Outer membrane efflux protein; Region: OEP; pfam02321
702113013339	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
702113013340	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
702113013341	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
702113013342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
702113013343	NAD(P) binding site [chemical binding]; other site
702113013344	active site
702113013345	Sulfatase; Region: Sulfatase; cl17466
702113013346	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
702113013347	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
702113013348	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
702113013349	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
702113013350	active site
702113013351	catalytic triad [active]
702113013352	oxyanion hole [active]
702113013353	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
702113013354	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
702113013355	metal binding site [ion binding]; metal-binding site
702113013356	active site
702113013357	I-site; other site
702113013358	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113013359	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113013360	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
702113013361	active site
702113013362	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
702113013363	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
702113013364	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
702113013365	active site
702113013366	Secretin and TonB N terminus short domain; Region: STN; smart00965
702113013367	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
702113013368	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
702113013369	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
702113013370	FecR protein; Region: FecR; pfam04773
702113013371	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
702113013372	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
702113013373	DNA binding residues [nucleotide binding]
702113013374	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
702113013375	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
702113013376	TM-ABC transporter signature motif; other site
702113013377	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
702113013378	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
702113013379	Walker A/P-loop; other site
702113013380	ATP binding site [chemical binding]; other site
702113013381	Q-loop/lid; other site
702113013382	ABC transporter signature motif; other site
702113013383	Walker B; other site
702113013384	D-loop; other site
702113013385	H-loop/switch region; other site
702113013386	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
702113013387	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
702113013388	Walker A/P-loop; other site
702113013389	ATP binding site [chemical binding]; other site
702113013390	Q-loop/lid; other site
702113013391	ABC transporter signature motif; other site
702113013392	Walker B; other site
702113013393	D-loop; other site
702113013394	H-loop/switch region; other site
702113013395	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
702113013396	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
702113013397	TM-ABC transporter signature motif; other site
702113013398	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
702113013399	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
702113013400	putative ligand binding site [chemical binding]; other site
702113013401	Transcriptional regulators [Transcription]; Region: FadR; COG2186
702113013402	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113013403	DNA-binding site [nucleotide binding]; DNA binding site
702113013404	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
702113013405	Amidase; Region: Amidase; cl11426
702113013406	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
702113013407	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
702113013408	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
702113013409	SnoaL-like domain; Region: SnoaL_3; pfam13474
702113013410	Transcriptional regulators [Transcription]; Region: GntR; COG1802
702113013411	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113013412	DNA-binding site [nucleotide binding]; DNA binding site
702113013413	FCD domain; Region: FCD; pfam07729
702113013414	cytosine deaminase; Provisional; Region: PRK05985
702113013415	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
702113013416	active site
702113013417	cytosine deaminase; Provisional; Region: PRK05985
702113013418	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
702113013419	active site
702113013420	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
702113013421	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
702113013422	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
702113013423	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
702113013424	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
702113013425	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
702113013426	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
702113013427	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
702113013428	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
702113013429	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
702113013430	putative active site [active]
702113013431	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
702113013432	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
702113013433	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
702113013434	Ligand binding site; other site
702113013435	oligomer interface; other site
702113013436	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
702113013437	catalytic core [active]
702113013438	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
702113013439	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
702113013440	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
702113013441	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
702113013442	Integrase core domain; Region: rve; pfam00665
702113013443	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
702113013444	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
702113013445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
702113013446	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
702113013447	Integrase core domain; Region: rve; pfam00665
702113013448	Transcriptional regulators [Transcription]; Region: GntR; COG1802
702113013449	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
702113013450	DNA-binding site [nucleotide binding]; DNA binding site
702113013451	FCD domain; Region: FCD; pfam07729
702113013452	Predicted acyl esterases [General function prediction only]; Region: COG2936
702113013453	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
702113013454	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
702113013455	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
702113013456	putative active site [active]
702113013457	putative metal binding site [ion binding]; other site
702113013458	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
702113013459	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113013460	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113013461	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
702113013462	benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260
702113013463	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
702113013464	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
702113013465	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
702113013466	CoA-transferase family III; Region: CoA_transf_3; pfam02515
702113013467	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
702113013468	Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105
702113013469	NAD(P) binding site [chemical binding]; other site
702113013470	catalytic residues [active]