-- dump date 20140619_223755 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391626000001 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391626000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391626000003 P-loop; other site 391626000004 Magnesium ion binding site [ion binding]; other site 391626000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391626000006 Magnesium ion binding site [ion binding]; other site 391626000007 ParB-like nuclease domain; Region: ParBc; pfam02195 391626000008 RepB plasmid partitioning protein; Region: RepB; pfam07506 391626000009 replication initiation protein RepC; Provisional; Region: PRK13824 391626000010 Replication protein C N-terminal domain; Region: RP-C; pfam03428 391626000011 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 391626000012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626000013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626000014 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626000015 putative effector binding pocket; other site 391626000016 dimerization interface [polypeptide binding]; other site 391626000017 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 391626000018 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 391626000019 heme binding site [chemical binding]; other site 391626000020 ferroxidase pore; other site 391626000021 ferroxidase diiron center [ion binding]; other site 391626000022 acetolactate synthase; Reviewed; Region: PRK08322 391626000023 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626000024 PYR/PP interface [polypeptide binding]; other site 391626000025 dimer interface [polypeptide binding]; other site 391626000026 TPP binding site [chemical binding]; other site 391626000027 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626000028 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626000029 TPP-binding site [chemical binding]; other site 391626000030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626000031 substrate binding pocket [chemical binding]; other site 391626000032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626000033 membrane-bound complex binding site; other site 391626000034 hypothetical protein; Provisional; Region: PRK08201 391626000035 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 391626000036 metal binding site [ion binding]; metal-binding site 391626000037 putative dimer interface [polypeptide binding]; other site 391626000038 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626000039 classical (c) SDRs; Region: SDR_c; cd05233 391626000040 NAD(P) binding site [chemical binding]; other site 391626000041 active site 391626000042 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 391626000043 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 391626000044 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 391626000045 Creatinine amidohydrolase; Region: Creatininase; pfam02633 391626000046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391626000047 MarR family; Region: MarR_2; pfam12802 391626000048 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626000049 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391626000050 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626000051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000052 dimer interface [polypeptide binding]; other site 391626000053 conserved gate region; other site 391626000054 putative PBP binding loops; other site 391626000055 ABC-ATPase subunit interface; other site 391626000056 dipeptide transporter; Provisional; Region: PRK10913 391626000057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000058 dimer interface [polypeptide binding]; other site 391626000059 conserved gate region; other site 391626000060 putative PBP binding loops; other site 391626000061 ABC-ATPase subunit interface; other site 391626000062 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391626000063 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626000064 Walker A/P-loop; other site 391626000065 ATP binding site [chemical binding]; other site 391626000066 Q-loop/lid; other site 391626000067 ABC transporter signature motif; other site 391626000068 Walker B; other site 391626000069 D-loop; other site 391626000070 H-loop/switch region; other site 391626000071 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626000072 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391626000073 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626000074 Walker A/P-loop; other site 391626000075 ATP binding site [chemical binding]; other site 391626000076 Q-loop/lid; other site 391626000077 ABC transporter signature motif; other site 391626000078 Walker B; other site 391626000079 D-loop; other site 391626000080 H-loop/switch region; other site 391626000081 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626000082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626000083 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 391626000084 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391626000085 dimerization interface [polypeptide binding]; other site 391626000086 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 391626000087 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626000088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626000089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000090 dimer interface [polypeptide binding]; other site 391626000091 conserved gate region; other site 391626000092 ABC-ATPase subunit interface; other site 391626000093 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626000094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000095 dimer interface [polypeptide binding]; other site 391626000096 conserved gate region; other site 391626000097 putative PBP binding loops; other site 391626000098 ABC-ATPase subunit interface; other site 391626000099 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391626000100 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391626000101 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391626000102 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626000103 active site 391626000104 metal binding site [ion binding]; metal-binding site 391626000105 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391626000106 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626000107 Walker A/P-loop; other site 391626000108 ATP binding site [chemical binding]; other site 391626000109 Q-loop/lid; other site 391626000110 ABC transporter signature motif; other site 391626000111 Walker B; other site 391626000112 D-loop; other site 391626000113 H-loop/switch region; other site 391626000114 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626000115 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626000116 Walker A/P-loop; other site 391626000117 ATP binding site [chemical binding]; other site 391626000118 Q-loop/lid; other site 391626000119 ABC transporter signature motif; other site 391626000120 Walker B; other site 391626000121 D-loop; other site 391626000122 H-loop/switch region; other site 391626000123 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391626000124 malonyl-CoA synthase; Validated; Region: PRK07514 391626000125 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 391626000126 acyl-activating enzyme (AAE) consensus motif; other site 391626000127 active site 391626000128 AMP binding site [chemical binding]; other site 391626000129 CoA binding site [chemical binding]; other site 391626000130 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 391626000131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 391626000132 DNA-binding site [nucleotide binding]; DNA binding site 391626000133 FCD domain; Region: FCD; pfam07729 391626000134 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391626000135 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391626000136 enoyl-CoA hydratase; Provisional; Region: PRK06127 391626000137 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626000138 substrate binding site [chemical binding]; other site 391626000139 oxyanion hole (OAH) forming residues; other site 391626000140 trimer interface [polypeptide binding]; other site 391626000141 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391626000142 CoenzymeA binding site [chemical binding]; other site 391626000143 subunit interaction site [polypeptide binding]; other site 391626000144 PHB binding site; other site 391626000145 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391626000146 Winged helix-turn helix; Region: HTH_29; pfam13551 391626000147 Integrase core domain; Region: rve; pfam00665 391626000148 Integrase core domain; Region: rve_3; pfam13683 391626000149 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391626000150 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391626000151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391626000152 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391626000153 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000154 NAD(P) binding site [chemical binding]; other site 391626000155 active site 391626000156 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 391626000157 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391626000158 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391626000159 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 391626000160 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391626000161 metal binding site [ion binding]; metal-binding site 391626000162 substrate binding pocket [chemical binding]; other site 391626000163 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626000164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391626000165 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626000166 active site 391626000167 catalytic residues [active] 391626000168 DNA binding site [nucleotide binding] 391626000169 Int/Topo IB signature motif; other site 391626000170 Predicted membrane protein [Function unknown]; Region: COG2364 391626000171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626000172 Transposase; Region: HTH_Tnp_1; pfam01527 391626000173 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391626000174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391626000175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626000176 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626000177 WHG domain; Region: WHG; pfam13305 391626000178 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626000179 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391626000180 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626000181 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626000182 Protein export membrane protein; Region: SecD_SecF; cl14618 391626000183 Translation initiation factor SUI1; Region: SUI1; pfam01253 391626000184 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 391626000185 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 391626000186 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391626000187 DNA binding residues [nucleotide binding] 391626000188 putative dimer interface [polypeptide binding]; other site 391626000189 putative metal binding residues [ion binding]; other site 391626000190 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 391626000191 DnaA N-terminal domain; Region: DnaA_N; pfam11638 391626000192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626000193 Walker A motif; other site 391626000194 ATP binding site [chemical binding]; other site 391626000195 Walker B motif; other site 391626000196 arginine finger; other site 391626000197 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391626000198 DnaA box-binding interface [nucleotide binding]; other site 391626000199 DNA polymerase III subunit beta; Validated; Region: PRK05643 391626000200 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391626000201 putative DNA binding surface [nucleotide binding]; other site 391626000202 dimer interface [polypeptide binding]; other site 391626000203 beta-clamp/clamp loader binding surface; other site 391626000204 beta-clamp/translesion DNA polymerase binding surface; other site 391626000205 recombination protein F; Reviewed; Region: recF; PRK00064 391626000206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626000207 Walker A/P-loop; other site 391626000208 ATP binding site [chemical binding]; other site 391626000209 Q-loop/lid; other site 391626000210 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626000211 ABC transporter signature motif; other site 391626000212 Walker B; other site 391626000213 D-loop; other site 391626000214 H-loop/switch region; other site 391626000215 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 391626000216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626000217 ATP binding site [chemical binding]; other site 391626000218 Mg2+ binding site [ion binding]; other site 391626000219 G-X-G motif; other site 391626000220 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391626000221 anchoring element; other site 391626000222 dimer interface [polypeptide binding]; other site 391626000223 ATP binding site [chemical binding]; other site 391626000224 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391626000225 active site 391626000226 putative metal-binding site [ion binding]; other site 391626000227 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391626000228 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626000229 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391626000230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626000231 catalytic residue [active] 391626000232 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 391626000233 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 391626000234 active site residue [active] 391626000235 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391626000236 Isochorismatase family; Region: Isochorismatase; pfam00857 391626000237 catalytic triad [active] 391626000238 metal binding site [ion binding]; metal-binding site 391626000239 conserved cis-peptide bond; other site 391626000240 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391626000241 Proline racemase; Region: Pro_racemase; pfam05544 391626000242 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 391626000243 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 391626000244 active site 391626000245 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391626000246 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626000247 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626000248 Integrase core domain; Region: rve; pfam00665 391626000249 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 391626000250 active site 391626000251 dimer interface [polypeptide binding]; other site 391626000252 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391626000253 Clp amino terminal domain; Region: Clp_N; pfam02861 391626000254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626000255 Walker A motif; other site 391626000256 ATP binding site [chemical binding]; other site 391626000257 Walker B motif; other site 391626000258 arginine finger; other site 391626000259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626000260 Walker A motif; other site 391626000261 ATP binding site [chemical binding]; other site 391626000262 Walker B motif; other site 391626000263 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391626000264 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391626000265 Fasciclin domain; Region: Fasciclin; pfam02469 391626000266 TMAO/DMSO reductase; Reviewed; Region: PRK05363 391626000267 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391626000268 Moco binding site; other site 391626000269 metal coordination site [ion binding]; other site 391626000270 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 391626000271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626000273 putative substrate translocation pore; other site 391626000274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626000275 Integrase core domain; Region: rve; pfam00665 391626000276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626000277 Q-loop/lid; other site 391626000278 ABC transporter signature motif; other site 391626000279 Walker B; other site 391626000280 D-loop; other site 391626000281 H-loop/switch region; other site 391626000282 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391626000283 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626000284 substrate binding site [chemical binding]; other site 391626000285 ATP binding site [chemical binding]; other site 391626000286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391626000287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626000288 DNA-binding site [nucleotide binding]; DNA binding site 391626000289 FCD domain; Region: FCD; pfam07729 391626000290 glucuronate isomerase; Reviewed; Region: PRK02925 391626000291 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 391626000292 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626000293 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391626000294 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391626000295 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626000296 DctM-like transporters; Region: DctM; pfam06808 391626000297 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 391626000298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000299 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391626000300 NAD(P) binding site [chemical binding]; other site 391626000301 active site 391626000302 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391626000303 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391626000304 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391626000305 mannonate dehydratase; Provisional; Region: PRK03906 391626000306 mannonate dehydratase; Region: uxuA; TIGR00695 391626000307 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 391626000308 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626000309 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626000310 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 391626000311 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 391626000312 putative NAD(P) binding site [chemical binding]; other site 391626000313 catalytic Zn binding site [ion binding]; other site 391626000314 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 391626000315 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 391626000316 NADP binding site [chemical binding]; other site 391626000317 homodimer interface [polypeptide binding]; other site 391626000318 active site 391626000319 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391626000320 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391626000321 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391626000322 active site pocket [active] 391626000323 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 391626000324 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391626000325 putative ligand binding site [chemical binding]; other site 391626000326 NAD binding site [chemical binding]; other site 391626000327 catalytic site [active] 391626000328 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391626000329 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391626000330 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 391626000331 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391626000332 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 391626000333 NAD binding site [chemical binding]; other site 391626000334 homotetramer interface [polypeptide binding]; other site 391626000335 homodimer interface [polypeptide binding]; other site 391626000336 active site 391626000337 galactarate dehydratase; Region: galactar-dH20; TIGR03248 391626000338 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 391626000339 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 391626000340 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626000341 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626000342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626000343 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626000344 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391626000345 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 391626000346 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 391626000347 putative aldolase; Validated; Region: PRK08130 391626000348 intersubunit interface [polypeptide binding]; other site 391626000349 active site 391626000350 Zn2+ binding site [ion binding]; other site 391626000351 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391626000352 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 391626000353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626000354 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 391626000355 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391626000356 TPP-binding site [chemical binding]; other site 391626000357 dimer interface [polypeptide binding]; other site 391626000358 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 391626000359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391626000360 PYR/PP interface [polypeptide binding]; other site 391626000361 dimer interface [polypeptide binding]; other site 391626000362 TPP binding site [chemical binding]; other site 391626000363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391626000364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626000365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000366 NAD(P) binding site [chemical binding]; other site 391626000367 active site 391626000368 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391626000369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626000370 DNA-binding site [nucleotide binding]; DNA binding site 391626000371 FCD domain; Region: FCD; pfam07729 391626000372 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626000373 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626000374 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626000375 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626000376 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626000377 EamA-like transporter family; Region: EamA; pfam00892 391626000378 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391626000379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 391626000380 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 391626000381 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 391626000382 dimer interface [polypeptide binding]; other site 391626000383 active site 391626000384 catalytic residue [active] 391626000385 metal binding site [ion binding]; metal-binding site 391626000386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000387 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626000388 NAD(P) binding site [chemical binding]; other site 391626000389 active site 391626000390 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391626000391 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 391626000392 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391626000393 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391626000394 classical (c) SDRs; Region: SDR_c; cd05233 391626000395 NAD(P) binding site [chemical binding]; other site 391626000396 active site 391626000397 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626000398 classical (c) SDRs; Region: SDR_c; cd05233 391626000399 NAD(P) binding site [chemical binding]; other site 391626000400 active site 391626000401 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391626000402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000403 NAD(P) binding site [chemical binding]; other site 391626000404 active site 391626000405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626000406 Transposase; Region: HTH_Tnp_1; cl17663 391626000407 HTH-like domain; Region: HTH_21; pfam13276 391626000408 Integrase core domain; Region: rve; pfam00665 391626000409 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626000410 EamA-like transporter family; Region: EamA; pfam00892 391626000411 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626000412 Putative transposase; Region: Y2_Tnp; pfam04986 391626000413 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 391626000414 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391626000415 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 391626000416 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 391626000417 putative di-iron ligands [ion binding]; other site 391626000418 Imelysin; Region: Peptidase_M75; cl09159 391626000419 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391626000420 putative hydrophobic ligand binding site [chemical binding]; other site 391626000421 protein interface [polypeptide binding]; other site 391626000422 gate; other site 391626000423 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391626000424 putative hydrophobic ligand binding site [chemical binding]; other site 391626000425 protein interface [polypeptide binding]; other site 391626000426 gate; other site 391626000427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626000428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626000429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626000430 dimerization interface [polypeptide binding]; other site 391626000431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626000432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626000433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626000434 dimerization interface [polypeptide binding]; other site 391626000435 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626000436 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626000437 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626000438 Integrase core domain; Region: rve; pfam00665 391626000439 transposase/IS protein; Provisional; Region: PRK09183 391626000440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626000441 Walker A motif; other site 391626000442 ATP binding site [chemical binding]; other site 391626000443 Walker B motif; other site 391626000444 arginine finger; other site 391626000445 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626000446 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626000447 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626000448 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626000449 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391626000450 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 391626000451 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626000452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000453 NAD(P) binding site [chemical binding]; other site 391626000454 active site 391626000455 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626000456 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626000457 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626000458 dimerization interface [polypeptide binding]; other site 391626000459 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626000460 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626000461 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 391626000462 active site 391626000463 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 391626000464 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391626000465 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391626000466 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 391626000467 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391626000468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626000469 FeS/SAM binding site; other site 391626000470 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391626000471 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626000472 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 391626000473 putative N-terminal domain interface [polypeptide binding]; other site 391626000474 putative dimer interface [polypeptide binding]; other site 391626000475 putative substrate binding pocket (H-site) [chemical binding]; other site 391626000476 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 391626000477 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626000478 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391626000479 putative C-terminal domain interface [polypeptide binding]; other site 391626000480 putative GSH binding site (G-site) [chemical binding]; other site 391626000481 putative dimer interface [polypeptide binding]; other site 391626000482 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 391626000483 dimer interface [polypeptide binding]; other site 391626000484 N-terminal domain interface [polypeptide binding]; other site 391626000485 putative substrate binding pocket (H-site) [chemical binding]; other site 391626000486 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391626000487 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391626000488 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391626000489 [2Fe-2S] cluster binding site [ion binding]; other site 391626000490 cytochrome b; Provisional; Region: CYTB; MTH00191 391626000491 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 391626000492 Qi binding site; other site 391626000493 intrachain domain interface; other site 391626000494 interchain domain interface [polypeptide binding]; other site 391626000495 heme bH binding site [chemical binding]; other site 391626000496 heme bL binding site [chemical binding]; other site 391626000497 Qo binding site; other site 391626000498 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 391626000499 interchain domain interface [polypeptide binding]; other site 391626000500 intrachain domain interface; other site 391626000501 Qi binding site; other site 391626000502 Qo binding site; other site 391626000503 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 391626000504 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 391626000505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626000506 Walker A/P-loop; other site 391626000507 ATP binding site [chemical binding]; other site 391626000508 Q-loop/lid; other site 391626000509 ABC transporter signature motif; other site 391626000510 Walker B; other site 391626000511 D-loop; other site 391626000512 H-loop/switch region; other site 391626000513 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 391626000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000515 dimer interface [polypeptide binding]; other site 391626000516 conserved gate region; other site 391626000517 putative PBP binding loops; other site 391626000518 ABC-ATPase subunit interface; other site 391626000519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626000520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626000521 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 391626000522 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 391626000523 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391626000524 Tetramer interface [polypeptide binding]; other site 391626000525 active site 391626000526 FMN-binding site [chemical binding]; other site 391626000527 EamA-like transporter family; Region: EamA; pfam00892 391626000528 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391626000529 EamA-like transporter family; Region: EamA; pfam00892 391626000530 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391626000531 IHF dimer interface [polypeptide binding]; other site 391626000532 IHF - DNA interface [nucleotide binding]; other site 391626000533 AMP nucleosidase; Provisional; Region: PRK08292 391626000534 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 391626000535 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 391626000536 hypothetical protein; Provisional; Region: PRK07490 391626000537 intersubunit interface [polypeptide binding]; other site 391626000538 active site 391626000539 Zn2+ binding site [ion binding]; other site 391626000540 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391626000541 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391626000542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626000543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626000544 active site 391626000545 CoA binding domain; Region: CoA_binding_2; pfam13380 391626000546 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391626000547 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 391626000548 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 391626000549 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 391626000550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626000551 substrate binding site [chemical binding]; other site 391626000552 oxyanion hole (OAH) forming residues; other site 391626000553 trimer interface [polypeptide binding]; other site 391626000554 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391626000555 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391626000556 active site 391626000557 trimer interface [polypeptide binding]; other site 391626000558 dimer interface [polypeptide binding]; other site 391626000559 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 391626000560 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391626000561 NAD(P) binding site [chemical binding]; other site 391626000562 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 391626000563 Transposase; Region: HTH_Tnp_1; pfam01527 391626000564 HTH-like domain; Region: HTH_21; pfam13276 391626000565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626000566 Integrase core domain; Region: rve_3; pfam13683 391626000567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626000568 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626000569 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626000570 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 391626000571 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391626000572 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 391626000573 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391626000574 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391626000575 Walker A/P-loop; other site 391626000576 ATP binding site [chemical binding]; other site 391626000577 Q-loop/lid; other site 391626000578 ABC transporter signature motif; other site 391626000579 Walker B; other site 391626000580 D-loop; other site 391626000581 H-loop/switch region; other site 391626000582 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391626000583 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391626000584 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 391626000585 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 391626000586 tandem repeat interface [polypeptide binding]; other site 391626000587 oligomer interface [polypeptide binding]; other site 391626000588 active site residues [active] 391626000589 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 391626000590 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391626000591 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391626000592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626000593 short chain dehydrogenase; Provisional; Region: PRK09134 391626000594 NAD(P) binding site [chemical binding]; other site 391626000595 active site 391626000596 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391626000597 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391626000598 GIY-YIG motif/motif A; other site 391626000599 active site 391626000600 catalytic site [active] 391626000601 putative DNA binding site [nucleotide binding]; other site 391626000602 metal binding site [ion binding]; metal-binding site 391626000603 UvrB/uvrC motif; Region: UVR; pfam02151 391626000604 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391626000605 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391626000606 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 391626000607 MoaE interaction surface [polypeptide binding]; other site 391626000608 MoeB interaction surface [polypeptide binding]; other site 391626000609 thiocarboxylated glycine; other site 391626000610 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391626000611 MoaE homodimer interface [polypeptide binding]; other site 391626000612 MoaD interaction [polypeptide binding]; other site 391626000613 active site residues [active] 391626000614 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 391626000615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626000616 putative acyltransferase; Provisional; Region: PRK05790 391626000617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626000618 dimer interface [polypeptide binding]; other site 391626000619 active site 391626000620 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 391626000621 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391626000622 NAD(P) binding site [chemical binding]; other site 391626000623 homotetramer interface [polypeptide binding]; other site 391626000624 homodimer interface [polypeptide binding]; other site 391626000625 active site 391626000626 Protein of unknown function (DUF465); Region: DUF465; pfam04325 391626000627 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 391626000628 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391626000629 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391626000630 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391626000631 substrate binding pocket [chemical binding]; other site 391626000632 chain length determination region; other site 391626000633 substrate-Mg2+ binding site; other site 391626000634 catalytic residues [active] 391626000635 aspartate-rich region 1; other site 391626000636 active site lid residues [active] 391626000637 aspartate-rich region 2; other site 391626000638 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 391626000639 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 391626000640 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626000641 TPR motif; other site 391626000642 binding surface 391626000643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626000644 TPR motif; other site 391626000645 binding surface 391626000646 TPR repeat; Region: TPR_11; pfam13414 391626000647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626000648 binding surface 391626000649 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391626000650 TPR motif; other site 391626000651 TPR repeat; Region: TPR_11; pfam13414 391626000652 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 391626000653 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626000654 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 391626000655 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391626000656 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 391626000657 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 391626000658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626000659 Coenzyme A binding pocket [chemical binding]; other site 391626000660 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391626000661 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391626000662 GTP binding site; other site 391626000663 AzlC protein; Region: AzlC; pfam03591 391626000664 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 391626000665 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626000666 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391626000667 putative DNA binding site [nucleotide binding]; other site 391626000668 putative Zn2+ binding site [ion binding]; other site 391626000669 AsnC family; Region: AsnC_trans_reg; pfam01037 391626000670 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391626000671 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626000672 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626000673 active site 391626000674 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391626000675 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391626000676 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 391626000677 Putative transcriptional regulator [Transcription]; Region: COG1678 391626000678 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 391626000679 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391626000680 active site 391626000681 Int/Topo IB signature motif; other site 391626000682 Helix-turn-helix domain; Region: HTH_17; pfam12728 391626000683 AAA domain; Region: AAA_25; pfam13481 391626000684 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626000685 Walker A motif; other site 391626000686 ATP binding site [chemical binding]; other site 391626000687 Walker B motif; other site 391626000688 RES domain; Region: RES; pfam08808 391626000689 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626000690 Protein export membrane protein; Region: SecD_SecF; cl14618 391626000691 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626000692 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626000693 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 391626000694 MPT binding site; other site 391626000695 trimer interface [polypeptide binding]; other site 391626000696 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391626000697 Fe-S cluster binding site [ion binding]; other site 391626000698 active site 391626000699 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 391626000700 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391626000701 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391626000702 dihydroorotase; Validated; Region: PRK09059 391626000703 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626000704 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 391626000705 active site 391626000706 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 391626000707 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 391626000708 glutamate--cysteine ligase; Region: PLN02611 391626000709 RNA methyltransferase, RsmE family; Region: TIGR00046 391626000710 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 391626000711 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 391626000712 UbiA prenyltransferase family; Region: UbiA; pfam01040 391626000713 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626000714 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626000715 ligand binding site [chemical binding]; other site 391626000716 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 391626000717 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391626000718 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391626000719 catalytic residues [active] 391626000720 argininosuccinate lyase; Provisional; Region: PRK00855 391626000721 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391626000722 active sites [active] 391626000723 tetramer interface [polypeptide binding]; other site 391626000724 diaminopimelate decarboxylase; Region: lysA; TIGR01048 391626000725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391626000726 active site 391626000727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391626000728 substrate binding site [chemical binding]; other site 391626000729 catalytic residues [active] 391626000730 dimer interface [polypeptide binding]; other site 391626000731 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 391626000732 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 391626000733 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 391626000734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391626000735 Walker A/P-loop; other site 391626000736 ATP binding site [chemical binding]; other site 391626000737 Q-loop/lid; other site 391626000738 ABC transporter signature motif; other site 391626000739 Walker B; other site 391626000740 D-loop; other site 391626000741 H-loop/switch region; other site 391626000742 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 391626000743 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391626000744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391626000745 putative acyl-acceptor binding pocket; other site 391626000746 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 391626000747 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 391626000748 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 391626000749 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391626000750 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391626000751 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 391626000752 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 391626000753 active site 391626000754 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391626000755 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391626000756 homodimer interface [polypeptide binding]; other site 391626000757 substrate-cofactor binding pocket; other site 391626000758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626000759 catalytic residue [active] 391626000760 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626000761 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626000762 ligand binding site [chemical binding]; other site 391626000763 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391626000764 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 391626000765 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391626000766 pyruvate kinase; Provisional; Region: PRK06247 391626000767 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 391626000768 domain interfaces; other site 391626000769 active site 391626000770 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 391626000771 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391626000772 23S rRNA binding site [nucleotide binding]; other site 391626000773 L21 binding site [polypeptide binding]; other site 391626000774 L13 binding site [polypeptide binding]; other site 391626000775 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626000776 Integrase core domain; Region: rve_3; pfam13683 391626000777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626000778 DNA topoisomerase III; Provisional; Region: PRK07726 391626000779 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 391626000780 active site 391626000781 interdomain interaction site; other site 391626000782 putative metal-binding site [ion binding]; other site 391626000783 nucleotide binding site [chemical binding]; other site 391626000784 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 391626000785 domain I; other site 391626000786 DNA binding groove [nucleotide binding] 391626000787 phosphate binding site [ion binding]; other site 391626000788 domain II; other site 391626000789 domain III; other site 391626000790 nucleotide binding site [chemical binding]; other site 391626000791 catalytic site [active] 391626000792 domain IV; other site 391626000793 Transposase; Region: HTH_Tnp_1; pfam01527 391626000794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626000795 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391626000796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 391626000797 active site 391626000798 phosphorylation site [posttranslational modification] 391626000799 intermolecular recognition site; other site 391626000800 dimerization interface [polypeptide binding]; other site 391626000801 ANTAR domain; Region: ANTAR; pfam03861 391626000802 NMT1-like family; Region: NMT1_2; pfam13379 391626000803 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391626000804 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391626000805 NMT1-like family; Region: NMT1_2; pfam13379 391626000806 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626000807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626000808 dimer interface [polypeptide binding]; other site 391626000809 conserved gate region; other site 391626000810 putative PBP binding loops; other site 391626000811 ABC-ATPase subunit interface; other site 391626000812 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 391626000813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626000814 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626000815 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391626000816 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391626000817 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 391626000818 [2Fe-2S] cluster binding site [ion binding]; other site 391626000819 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391626000820 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 391626000821 [4Fe-4S] binding site [ion binding]; other site 391626000822 molybdopterin cofactor binding site; other site 391626000823 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 391626000824 molybdopterin cofactor binding site; other site 391626000825 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 391626000826 hypothetical protein; Validated; Region: PRK09071 391626000827 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391626000828 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391626000829 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 391626000830 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391626000831 active site 391626000832 SAM binding site [chemical binding]; other site 391626000833 homodimer interface [polypeptide binding]; other site 391626000834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626000835 Integrase core domain; Region: rve; pfam00665 391626000836 Transposase; Region: HTH_Tnp_1; pfam01527 391626000837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626000838 Integrase core domain; Region: rve_3; pfam13683 391626000839 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626000840 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626000841 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 391626000842 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391626000843 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391626000844 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626000845 Coenzyme A binding pocket [chemical binding]; other site 391626000846 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 391626000847 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391626000848 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391626000849 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391626000850 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 391626000851 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 391626000852 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391626000853 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391626000854 Walker A/P-loop; other site 391626000855 ATP binding site [chemical binding]; other site 391626000856 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 391626000857 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391626000858 Walker B; other site 391626000859 D-loop; other site 391626000860 H-loop/switch region; other site 391626000861 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626000862 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391626000863 murein hydrolase B; Provisional; Region: PRK10760; cl17906 391626000864 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626000865 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 391626000866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626000867 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 391626000868 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626000869 catalytic residue [active] 391626000870 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391626000871 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391626000872 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 391626000873 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391626000874 putative dimer interface [polypeptide binding]; other site 391626000875 N-terminal domain interface [polypeptide binding]; other site 391626000876 putative substrate binding pocket (H-site) [chemical binding]; other site 391626000877 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 391626000878 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391626000879 putative active site [active] 391626000880 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 391626000881 putative active site [active] 391626000882 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 391626000883 Precorrin-8X methylmutase; Region: CbiC; pfam02570 391626000884 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 391626000885 active site 391626000886 putative homodimer interface [polypeptide binding]; other site 391626000887 SAM binding site [chemical binding]; other site 391626000888 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 391626000889 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 391626000890 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 391626000891 active site 391626000892 SAM binding site [chemical binding]; other site 391626000893 homodimer interface [polypeptide binding]; other site 391626000894 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 391626000895 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 391626000896 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 391626000897 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 391626000898 active site 391626000899 SAM binding site [chemical binding]; other site 391626000900 homodimer interface [polypeptide binding]; other site 391626000901 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 391626000902 active site 391626000903 SAM binding site [chemical binding]; other site 391626000904 homodimer interface [polypeptide binding]; other site 391626000905 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 391626000906 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626000907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626000908 homodimer interface [polypeptide binding]; other site 391626000909 catalytic residue [active] 391626000910 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391626000911 active site 391626000912 catalytic residues [active] 391626000913 metal binding site [ion binding]; metal-binding site 391626000914 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391626000915 active site 391626000916 catalytic residues [active] 391626000917 metal binding site [ion binding]; metal-binding site 391626000918 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391626000919 active site 391626000920 catalytic residues [active] 391626000921 metal binding site [ion binding]; metal-binding site 391626000922 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391626000923 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391626000924 putative active site [active] 391626000925 substrate binding site [chemical binding]; other site 391626000926 putative cosubstrate binding site; other site 391626000927 catalytic site [active] 391626000928 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391626000929 substrate binding site [chemical binding]; other site 391626000930 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 391626000931 RNA/DNA hybrid binding site [nucleotide binding]; other site 391626000932 active site 391626000933 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391626000934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626000935 S-adenosylmethionine binding site [chemical binding]; other site 391626000936 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 391626000937 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 391626000938 Uncharacterized conserved protein [Function unknown]; Region: COG1432 391626000939 LabA_like proteins; Region: LabA; cd10911 391626000940 putative metal binding site [ion binding]; other site 391626000941 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391626000942 catalytic center binding site [active] 391626000943 ATP binding site [chemical binding]; other site 391626000944 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 391626000945 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391626000946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391626000947 Zn2+ binding site [ion binding]; other site 391626000948 Mg2+ binding site [ion binding]; other site 391626000949 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391626000950 synthetase active site [active] 391626000951 NTP binding site [chemical binding]; other site 391626000952 metal binding site [ion binding]; metal-binding site 391626000953 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391626000954 ACT domain; Region: ACT_4; pfam13291 391626000955 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 391626000956 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 391626000957 active site 391626000958 hydrophilic channel; other site 391626000959 dimerization interface [polypeptide binding]; other site 391626000960 catalytic residues [active] 391626000961 active site lid [active] 391626000962 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391626000963 LysE type translocator; Region: LysE; cl00565 391626000964 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 391626000965 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391626000966 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391626000967 Catalytic site [active] 391626000968 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391626000969 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 391626000970 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 391626000971 dimerization interface [polypeptide binding]; other site 391626000972 active site 391626000973 metal binding site [ion binding]; metal-binding site 391626000974 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 391626000975 dsRNA binding site [nucleotide binding]; other site 391626000976 GTPase Era; Reviewed; Region: era; PRK00089 391626000977 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 391626000978 G1 box; other site 391626000979 GTP/Mg2+ binding site [chemical binding]; other site 391626000980 Switch I region; other site 391626000981 G2 box; other site 391626000982 Switch II region; other site 391626000983 G3 box; other site 391626000984 G4 box; other site 391626000985 G5 box; other site 391626000986 KH domain; Region: KH_2; pfam07650 391626000987 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 391626000988 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391626000989 Recombination protein O N terminal; Region: RecO_N; pfam11967 391626000990 Recombination protein O C terminal; Region: RecO_C; pfam02565 391626000991 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 391626000992 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626000993 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626000994 active site 391626000995 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391626000996 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 391626000997 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 391626000998 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 391626000999 active site 391626001000 substrate-binding site [chemical binding]; other site 391626001001 metal-binding site [ion binding] 391626001002 ATP binding site [chemical binding]; other site 391626001003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626001004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626001005 active site 391626001006 phosphorylation site [posttranslational modification] 391626001007 intermolecular recognition site; other site 391626001008 dimerization interface [polypeptide binding]; other site 391626001009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626001010 DNA binding site [nucleotide binding] 391626001011 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 391626001012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626001013 HAMP domain; Region: HAMP; pfam00672 391626001014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626001015 dimer interface [polypeptide binding]; other site 391626001016 phosphorylation site [posttranslational modification] 391626001017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626001018 ATP binding site [chemical binding]; other site 391626001019 Mg2+ binding site [ion binding]; other site 391626001020 G-X-G motif; other site 391626001021 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 391626001022 Hpr binding site; other site 391626001023 active site 391626001024 homohexamer subunit interaction site [polypeptide binding]; other site 391626001025 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 391626001026 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 391626001027 active pocket/dimerization site; other site 391626001028 active site 391626001029 phosphorylation site [posttranslational modification] 391626001030 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391626001031 dimerization domain swap beta strand [polypeptide binding]; other site 391626001032 regulatory protein interface [polypeptide binding]; other site 391626001033 active site 391626001034 regulatory phosphorylation site [posttranslational modification]; other site 391626001035 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391626001036 putative acyl-acceptor binding pocket; other site 391626001037 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 391626001038 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391626001039 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391626001040 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391626001041 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391626001042 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391626001043 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391626001044 Ligand binding site [chemical binding]; other site 391626001045 Electron transfer flavoprotein domain; Region: ETF; pfam01012 391626001046 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 391626001047 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 391626001048 short chain dehydrogenase; Provisional; Region: PRK05993 391626001049 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391626001050 NADP binding site [chemical binding]; other site 391626001051 active site 391626001052 steroid binding site; other site 391626001053 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391626001054 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391626001055 CAP-like domain; other site 391626001056 active site 391626001057 primary dimer interface [polypeptide binding]; other site 391626001058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626001059 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 391626001060 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626001061 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626001062 Homeodomain-like domain; Region: HTH_32; pfam13565 391626001063 Integrase core domain; Region: rve; pfam00665 391626001064 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 391626001065 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391626001066 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391626001067 putative homodimer interface [polypeptide binding]; other site 391626001068 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 391626001069 heterodimer interface [polypeptide binding]; other site 391626001070 homodimer interface [polypeptide binding]; other site 391626001071 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391626001072 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391626001073 23S rRNA interface [nucleotide binding]; other site 391626001074 L7/L12 interface [polypeptide binding]; other site 391626001075 putative thiostrepton binding site; other site 391626001076 L25 interface [polypeptide binding]; other site 391626001077 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 391626001078 mRNA/rRNA interface [nucleotide binding]; other site 391626001079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626001080 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626001081 Integrase core domain; Region: rve_3; pfam13683 391626001082 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391626001083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626001084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626001085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626001086 dimerization interface [polypeptide binding]; other site 391626001087 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391626001088 putative hydrophobic ligand binding site [chemical binding]; other site 391626001089 protein interface [polypeptide binding]; other site 391626001090 gate; other site 391626001091 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 391626001092 putative hydrophobic ligand binding site [chemical binding]; other site 391626001093 protein interface [polypeptide binding]; other site 391626001094 gate; other site 391626001095 Phospholipid methyltransferase; Region: PEMT; pfam04191 391626001096 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 391626001097 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391626001098 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391626001099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626001100 DNA binding residues [nucleotide binding] 391626001101 dimerization interface [polypeptide binding]; other site 391626001102 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626001103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626001104 Walker A/P-loop; other site 391626001105 ATP binding site [chemical binding]; other site 391626001106 Q-loop/lid; other site 391626001107 ABC transporter signature motif; other site 391626001108 Walker B; other site 391626001109 D-loop; other site 391626001110 H-loop/switch region; other site 391626001111 TOBE domain; Region: TOBE_2; pfam08402 391626001112 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391626001113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626001114 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626001115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001116 dimer interface [polypeptide binding]; other site 391626001117 conserved gate region; other site 391626001118 putative PBP binding loops; other site 391626001119 ABC-ATPase subunit interface; other site 391626001120 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626001121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626001122 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626001123 classical (c) SDRs; Region: SDR_c; cd05233 391626001124 NAD(P) binding site [chemical binding]; other site 391626001125 active site 391626001126 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391626001127 BolA-like protein; Region: BolA; cl00386 391626001128 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 391626001129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626001130 FeS/SAM binding site; other site 391626001131 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391626001132 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 391626001133 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626001134 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 391626001135 DNA binding residues [nucleotide binding] 391626001136 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626001137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626001138 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 391626001139 DNA binding residues [nucleotide binding] 391626001140 dimerization interface [polypeptide binding]; other site 391626001141 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626001142 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626001143 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626001144 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626001145 Integrase core domain; Region: rve; pfam00665 391626001146 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626001147 Walker B motif; other site 391626001148 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391626001149 MltA-interacting protein MipA; Region: MipA; cl01504 391626001150 LytTr DNA-binding domain; Region: LytTR; smart00850 391626001151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626001152 Integrase core domain; Region: rve_3; pfam13683 391626001153 HTH-like domain; Region: HTH_21; pfam13276 391626001154 Transposase; Region: HTH_Tnp_1; pfam01527 391626001155 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391626001156 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391626001157 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391626001158 dimer interface [polypeptide binding]; other site 391626001159 motif 1; other site 391626001160 active site 391626001161 motif 2; other site 391626001162 motif 3; other site 391626001163 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 391626001164 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391626001165 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391626001166 putative tRNA-binding site [nucleotide binding]; other site 391626001167 B3/4 domain; Region: B3_4; pfam03483 391626001168 tRNA synthetase B5 domain; Region: B5; smart00874 391626001169 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 391626001170 dimer interface [polypeptide binding]; other site 391626001171 motif 1; other site 391626001172 motif 3; other site 391626001173 motif 2; other site 391626001174 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 391626001175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626001176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626001177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626001178 dimerization interface [polypeptide binding]; other site 391626001179 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391626001180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626001181 S-adenosylmethionine binding site [chemical binding]; other site 391626001182 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 391626001183 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626001184 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391626001185 C-terminal domain interface [polypeptide binding]; other site 391626001186 GSH binding site (G-site) [chemical binding]; other site 391626001187 dimer interface [polypeptide binding]; other site 391626001188 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 391626001189 dimer interface [polypeptide binding]; other site 391626001190 N-terminal domain interface [polypeptide binding]; other site 391626001191 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 391626001192 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 391626001193 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 391626001194 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 391626001195 hexamer interface [polypeptide binding]; other site 391626001196 ligand binding site [chemical binding]; other site 391626001197 putative active site [active] 391626001198 NAD(P) binding site [chemical binding]; other site 391626001199 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626001200 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626001201 putative DNA binding site [nucleotide binding]; other site 391626001202 putative Zn2+ binding site [ion binding]; other site 391626001203 AsnC family; Region: AsnC_trans_reg; pfam01037 391626001204 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 391626001205 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391626001206 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 391626001207 COQ9; Region: COQ9; pfam08511 391626001208 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391626001209 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391626001210 NAD(P) binding site [chemical binding]; other site 391626001211 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391626001212 classical (c) SDRs; Region: SDR_c; cd05233 391626001213 NAD(P) binding site [chemical binding]; other site 391626001214 active site 391626001215 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391626001216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626001217 motif II; other site 391626001218 L-asparaginase II; Region: Asparaginase_II; pfam06089 391626001219 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 391626001220 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 391626001221 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626001222 FeS/SAM binding site; other site 391626001223 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 391626001224 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391626001225 threonine dehydratase; Provisional; Region: PRK08246 391626001226 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626001227 catalytic residue [active] 391626001228 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626001229 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626001230 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 391626001231 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 391626001232 trimer interface [polypeptide binding]; other site 391626001233 active site 391626001234 substrate binding site [chemical binding]; other site 391626001235 CoA binding site [chemical binding]; other site 391626001236 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 391626001237 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 391626001238 metal binding site [ion binding]; metal-binding site 391626001239 dimer interface [polypeptide binding]; other site 391626001240 ribonuclease R; Region: RNase_R; TIGR02063 391626001241 RNB domain; Region: RNB; pfam00773 391626001242 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 391626001243 RNA binding site [nucleotide binding]; other site 391626001244 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391626001245 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626001246 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626001247 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626001248 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 391626001249 putative active site [active] 391626001250 Ap4A binding site [chemical binding]; other site 391626001251 nudix motif; other site 391626001252 putative metal binding site [ion binding]; other site 391626001253 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 391626001254 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 391626001255 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 391626001256 protein binding site [polypeptide binding]; other site 391626001257 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 391626001258 Catalytic dyad [active] 391626001259 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 391626001260 Peptidase family M23; Region: Peptidase_M23; pfam01551 391626001261 phosphoglyceromutase; Provisional; Region: PRK05434 391626001262 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 391626001263 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 391626001264 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 391626001265 Predicted permease; Region: DUF318; cl17795 391626001266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626001267 dimerization interface [polypeptide binding]; other site 391626001268 putative DNA binding site [nucleotide binding]; other site 391626001269 putative Zn2+ binding site [ion binding]; other site 391626001270 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626001271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626001272 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626001273 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391626001274 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391626001275 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391626001276 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391626001277 substrate binding site [chemical binding]; other site 391626001278 ligand binding site [chemical binding]; other site 391626001279 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391626001280 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391626001281 substrate binding site [chemical binding]; other site 391626001282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626001283 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626001284 NAD(P) binding site [chemical binding]; other site 391626001285 active site 391626001286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626001287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626001288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391626001289 dimerization interface [polypeptide binding]; other site 391626001290 tartrate dehydrogenase; Region: TTC; TIGR02089 391626001291 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 391626001292 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626001293 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626001294 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626001295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626001296 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391626001297 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626001298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626001299 Integrase core domain; Region: rve_3; pfam13683 391626001300 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626001301 HTH-like domain; Region: HTH_21; pfam13276 391626001302 Transposase; Region: HTH_Tnp_1; pfam01527 391626001303 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391626001304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001305 dimer interface [polypeptide binding]; other site 391626001306 conserved gate region; other site 391626001307 putative PBP binding loops; other site 391626001308 ABC-ATPase subunit interface; other site 391626001309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626001310 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 391626001311 FixH; Region: FixH; pfam05751 391626001312 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 391626001313 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391626001314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391626001315 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 391626001316 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391626001317 Cytochrome c; Region: Cytochrom_C; pfam00034 391626001318 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 391626001319 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 391626001320 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 391626001321 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391626001322 Ligand Binding Site [chemical binding]; other site 391626001323 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391626001324 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391626001325 ligand binding site [chemical binding]; other site 391626001326 flexible hinge region; other site 391626001327 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391626001328 putative switch regulator; other site 391626001329 non-specific DNA interactions [nucleotide binding]; other site 391626001330 DNA binding site [nucleotide binding] 391626001331 sequence specific DNA binding site [nucleotide binding]; other site 391626001332 putative cAMP binding site [chemical binding]; other site 391626001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626001334 putative substrate translocation pore; other site 391626001335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626001336 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391626001337 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391626001338 Domain of unknown function (DUF897); Region: DUF897; cl01312 391626001339 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 391626001340 active site clefts [active] 391626001341 zinc binding site [ion binding]; other site 391626001342 dimer interface [polypeptide binding]; other site 391626001343 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 391626001344 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391626001345 interface (dimer of trimers) [polypeptide binding]; other site 391626001346 Substrate-binding/catalytic site; other site 391626001347 Zn-binding sites [ion binding]; other site 391626001348 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391626001349 NlpC/P60 family; Region: NLPC_P60; cl17555 391626001350 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 391626001351 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 391626001352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626001353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626001354 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 391626001355 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 391626001356 diiron binding motif [ion binding]; other site 391626001357 Uncharacterized conserved protein [Function unknown]; Region: COG1633 391626001358 CCC1-related protein family; Region: CCC1_like_1; cd02437 391626001359 Predicted permeases [General function prediction only]; Region: COG0679 391626001360 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 391626001361 putative FMN binding site [chemical binding]; other site 391626001362 putative dimer interface [polypeptide binding]; other site 391626001363 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 391626001364 S-formylglutathione hydrolase; Region: PLN02442 391626001365 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 391626001366 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 391626001367 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 391626001368 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391626001369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626001370 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391626001371 Predicted ATPase [General function prediction only]; Region: COG1485 391626001372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391626001373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391626001374 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 391626001375 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 391626001376 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 391626001377 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391626001378 CAAX protease self-immunity; Region: Abi; pfam02517 391626001379 Uncharacterized conserved protein [Function unknown]; Region: COG3603 391626001380 Family description; Region: ACT_7; pfam13840 391626001381 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 391626001382 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391626001383 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 391626001384 active site 391626001385 FMN binding site [chemical binding]; other site 391626001386 2,4-decadienoyl-CoA binding site; other site 391626001387 catalytic residue [active] 391626001388 4Fe-4S cluster binding site [ion binding]; other site 391626001389 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626001390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626001391 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626001392 putative effector binding pocket; other site 391626001393 dimerization interface [polypeptide binding]; other site 391626001394 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626001395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626001396 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626001397 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626001398 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626001399 ligand binding site [chemical binding]; other site 391626001400 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391626001401 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 391626001402 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391626001403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626001404 Coenzyme A binding pocket [chemical binding]; other site 391626001405 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 391626001406 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 391626001407 putative MPT binding site; other site 391626001408 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 391626001409 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391626001410 active site 391626001411 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391626001412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626001413 motif II; other site 391626001414 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 391626001415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626001416 S-adenosylmethionine binding site [chemical binding]; other site 391626001417 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 391626001418 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626001419 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626001420 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391626001421 catalytic triad [active] 391626001422 dimer interface [polypeptide binding]; other site 391626001423 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 391626001424 aromatic arch; other site 391626001425 DCoH dimer interaction site [polypeptide binding]; other site 391626001426 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391626001427 DCoH tetramer interaction site [polypeptide binding]; other site 391626001428 substrate binding site [chemical binding]; other site 391626001429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 391626001430 Protein of unknown function, DUF482; Region: DUF482; pfam04339 391626001431 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391626001432 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391626001433 active site 391626001434 catalytic site [active] 391626001435 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391626001436 homotrimer interaction site [polypeptide binding]; other site 391626001437 putative active site [active] 391626001438 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391626001439 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626001440 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391626001441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626001442 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 391626001443 Walker A/P-loop; other site 391626001444 ATP binding site [chemical binding]; other site 391626001445 Q-loop/lid; other site 391626001446 ABC transporter signature motif; other site 391626001447 Walker B; other site 391626001448 D-loop; other site 391626001449 H-loop/switch region; other site 391626001450 VacJ like lipoprotein; Region: VacJ; cl01073 391626001451 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 391626001452 Transglycosylase; Region: Transgly; pfam00912 391626001453 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391626001454 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391626001455 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 391626001456 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391626001457 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 391626001458 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391626001459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626001460 NAD(P) binding site [chemical binding]; other site 391626001461 active site 391626001462 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 391626001463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626001464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626001465 homodimer interface [polypeptide binding]; other site 391626001466 catalytic residue [active] 391626001467 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391626001468 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391626001469 active site residue [active] 391626001470 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391626001471 active site residue [active] 391626001472 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391626001473 SmpB-tmRNA interface; other site 391626001474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 391626001475 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 391626001476 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391626001477 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391626001478 dimer interface [polypeptide binding]; other site 391626001479 active site 391626001480 catalytic residue [active] 391626001481 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391626001482 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626001483 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626001484 catalytic residue [active] 391626001485 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626001486 Uncharacterized conserved protein [Function unknown]; Region: COG4121 391626001487 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626001488 Uncharacterized conserved protein [Function unknown]; Region: COG3777 391626001489 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391626001490 active site 2 [active] 391626001491 active site 1 [active] 391626001492 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 391626001493 dimer interface [polypeptide binding]; other site 391626001494 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626001495 metal binding site [ion binding]; metal-binding site 391626001496 Predicted flavoprotein [General function prediction only]; Region: COG0431 391626001497 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626001498 thiamine pyrophosphate protein; Validated; Region: PRK08199 391626001499 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626001500 PYR/PP interface [polypeptide binding]; other site 391626001501 dimer interface [polypeptide binding]; other site 391626001502 TPP binding site [chemical binding]; other site 391626001503 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626001504 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391626001505 TPP-binding site [chemical binding]; other site 391626001506 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 391626001507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391626001508 inhibitor-cofactor binding pocket; inhibition site 391626001509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626001510 catalytic residue [active] 391626001511 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391626001512 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391626001513 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391626001514 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626001515 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391626001516 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 391626001517 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626001518 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626001519 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626001520 DNA binding site [nucleotide binding] 391626001521 domain linker motif; other site 391626001522 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391626001523 putative dimerization interface [polypeptide binding]; other site 391626001524 putative ligand binding site [chemical binding]; other site 391626001525 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391626001526 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391626001527 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391626001528 sorbitol dehydrogenase; Provisional; Region: PRK07067 391626001529 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626001530 NAD(P) binding site [chemical binding]; other site 391626001531 active site 391626001532 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626001533 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626001534 Walker A/P-loop; other site 391626001535 ATP binding site [chemical binding]; other site 391626001536 Q-loop/lid; other site 391626001537 ABC transporter signature motif; other site 391626001538 Walker B; other site 391626001539 D-loop; other site 391626001540 H-loop/switch region; other site 391626001541 TOBE domain; Region: TOBE; pfam03459 391626001542 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626001543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001544 dimer interface [polypeptide binding]; other site 391626001545 conserved gate region; other site 391626001546 putative PBP binding loops; other site 391626001547 ABC-ATPase subunit interface; other site 391626001548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626001549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001550 putative PBP binding loops; other site 391626001551 dimer interface [polypeptide binding]; other site 391626001552 ABC-ATPase subunit interface; other site 391626001553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626001554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626001555 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626001556 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626001557 DNA binding site [nucleotide binding] 391626001558 domain linker motif; other site 391626001559 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391626001560 dimerization interface [polypeptide binding]; other site 391626001561 ligand binding site [chemical binding]; other site 391626001562 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626001563 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626001564 Homeodomain-like domain; Region: HTH_32; pfam13565 391626001565 Integrase core domain; Region: rve; pfam00665 391626001566 Transposase; Region: HTH_Tnp_1; cl17663 391626001567 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626001568 putative transposase OrfB; Reviewed; Region: PHA02517 391626001569 HTH-like domain; Region: HTH_21; pfam13276 391626001570 Integrase core domain; Region: rve; pfam00665 391626001571 Integrase core domain; Region: rve_3; pfam13683 391626001572 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 391626001573 recombination protein RecR; Reviewed; Region: recR; PRK00076 391626001574 RecR protein; Region: RecR; pfam02132 391626001575 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391626001576 putative active site [active] 391626001577 putative metal-binding site [ion binding]; other site 391626001578 tetramer interface [polypeptide binding]; other site 391626001579 hypothetical protein; Validated; Region: PRK00153 391626001580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626001581 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 391626001582 Walker A motif; other site 391626001583 ATP binding site [chemical binding]; other site 391626001584 Walker B motif; other site 391626001585 arginine finger; other site 391626001586 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391626001587 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 391626001588 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 391626001589 active site 391626001590 GTPase RsgA; Reviewed; Region: PRK01889 391626001591 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 391626001592 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391626001593 GTP/Mg2+ binding site [chemical binding]; other site 391626001594 G4 box; other site 391626001595 G5 box; other site 391626001596 G1 box; other site 391626001597 Switch I region; other site 391626001598 G2 box; other site 391626001599 G3 box; other site 391626001600 Switch II region; other site 391626001601 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 391626001602 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 391626001603 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 391626001604 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391626001605 putative NADH binding site [chemical binding]; other site 391626001606 putative active site [active] 391626001607 nudix motif; other site 391626001608 putative metal binding site [ion binding]; other site 391626001609 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391626001610 hydrophobic ligand binding site; other site 391626001611 prephenate dehydratase; Provisional; Region: PRK11899 391626001612 Prephenate dehydratase; Region: PDT; pfam00800 391626001613 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391626001614 putative L-Phe binding site [chemical binding]; other site 391626001615 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391626001616 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391626001617 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391626001618 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391626001619 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 391626001620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001621 putative PBP binding loops; other site 391626001622 dimer interface [polypeptide binding]; other site 391626001623 ABC-ATPase subunit interface; other site 391626001624 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 391626001625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001626 dimer interface [polypeptide binding]; other site 391626001627 conserved gate region; other site 391626001628 putative PBP binding loops; other site 391626001629 ABC-ATPase subunit interface; other site 391626001630 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391626001631 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626001632 Walker A/P-loop; other site 391626001633 ATP binding site [chemical binding]; other site 391626001634 Q-loop/lid; other site 391626001635 ABC transporter signature motif; other site 391626001636 Walker B; other site 391626001637 D-loop; other site 391626001638 H-loop/switch region; other site 391626001639 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626001640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626001641 Walker A/P-loop; other site 391626001642 ATP binding site [chemical binding]; other site 391626001643 Q-loop/lid; other site 391626001644 ABC transporter signature motif; other site 391626001645 Walker B; other site 391626001646 D-loop; other site 391626001647 H-loop/switch region; other site 391626001648 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626001649 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391626001650 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391626001651 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391626001652 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391626001653 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391626001654 Uncharacterized conserved protein [Function unknown]; Region: COG2127 391626001655 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 391626001656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626001657 S-adenosylmethionine binding site [chemical binding]; other site 391626001658 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391626001659 classical (c) SDRs; Region: SDR_c; cd05233 391626001660 NAD(P) binding site [chemical binding]; other site 391626001661 active site 391626001662 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 391626001663 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 391626001664 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 391626001665 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 391626001666 substrate binding site [chemical binding]; other site 391626001667 active site 391626001668 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391626001669 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 391626001670 domain interfaces; other site 391626001671 active site 391626001672 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391626001673 FAD binding domain; Region: FAD_binding_4; pfam01565 391626001674 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626001675 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 391626001676 active site 391626001677 catalytic residues [active] 391626001678 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 391626001679 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 391626001680 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391626001681 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391626001682 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 391626001683 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391626001684 active site 391626001685 intersubunit interface [polypeptide binding]; other site 391626001686 catalytic residue [active] 391626001687 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391626001688 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391626001689 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 391626001690 Melibiase; Region: Melibiase; pfam02065 391626001691 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626001692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001693 dimer interface [polypeptide binding]; other site 391626001694 conserved gate region; other site 391626001695 putative PBP binding loops; other site 391626001696 ABC-ATPase subunit interface; other site 391626001697 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626001699 dimer interface [polypeptide binding]; other site 391626001700 conserved gate region; other site 391626001701 putative PBP binding loops; other site 391626001702 ABC-ATPase subunit interface; other site 391626001703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626001704 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626001705 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391626001706 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391626001707 Bacterial transcriptional regulator; Region: IclR; pfam01614 391626001708 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626001709 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626001710 Walker A/P-loop; other site 391626001711 ATP binding site [chemical binding]; other site 391626001712 Q-loop/lid; other site 391626001713 ABC transporter signature motif; other site 391626001714 Walker B; other site 391626001715 D-loop; other site 391626001716 H-loop/switch region; other site 391626001717 TOBE domain; Region: TOBE_2; pfam08402 391626001718 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 391626001719 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 391626001720 4Fe-4S binding domain; Region: Fer4; pfam00037 391626001721 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391626001722 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391626001723 molybdopterin cofactor binding site; other site 391626001724 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391626001725 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 391626001726 putative molybdopterin cofactor binding site; other site 391626001727 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 391626001728 propionate/acetate kinase; Provisional; Region: PRK12379 391626001729 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 391626001730 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391626001731 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626001732 PYR/PP interface [polypeptide binding]; other site 391626001733 dimer interface [polypeptide binding]; other site 391626001734 TPP binding site [chemical binding]; other site 391626001735 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626001736 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626001737 TPP-binding site [chemical binding]; other site 391626001738 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391626001739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626001740 DNA-binding site [nucleotide binding]; DNA binding site 391626001741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626001742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626001743 homodimer interface [polypeptide binding]; other site 391626001744 catalytic residue [active] 391626001745 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 391626001746 aminotransferase; Validated; Region: PRK07678 391626001747 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391626001748 inhibitor-cofactor binding pocket; inhibition site 391626001749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626001750 catalytic residue [active] 391626001751 ATPase MipZ; Region: MipZ; pfam09140 391626001752 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391626001753 P-loop; other site 391626001754 Magnesium ion binding site [ion binding]; other site 391626001755 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391626001756 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391626001757 ATP binding site [chemical binding]; other site 391626001758 Mg++ binding site [ion binding]; other site 391626001759 motif III; other site 391626001760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626001761 nucleotide binding region [chemical binding]; other site 391626001762 ATP-binding site [chemical binding]; other site 391626001763 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391626001764 nudix motif; other site 391626001765 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 391626001766 Phosphate transporter family; Region: PHO4; pfam01384 391626001767 Cupin domain; Region: Cupin_2; pfam07883 391626001768 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 391626001769 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 391626001770 hypothetical protein; Provisional; Region: PRK10621 391626001771 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391626001772 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 391626001773 RimM N-terminal domain; Region: RimM; pfam01782 391626001774 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 391626001775 PRC-barrel domain; Region: PRC; pfam05239 391626001776 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 391626001777 chorismate mutase; Provisional; Region: PRK09239 391626001778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391626001779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626001780 signal recognition particle protein; Provisional; Region: PRK10867 391626001781 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391626001782 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391626001783 P loop; other site 391626001784 GTP binding site [chemical binding]; other site 391626001785 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391626001786 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391626001787 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626001788 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626001789 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626001790 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626001791 dimerization interface [polypeptide binding]; other site 391626001792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626001793 dimerization interface [polypeptide binding]; other site 391626001794 putative DNA binding site [nucleotide binding]; other site 391626001795 putative Zn2+ binding site [ion binding]; other site 391626001796 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 391626001797 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 391626001798 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 391626001799 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 391626001800 F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454 391626001801 F0F1 ATP synthase subunit B; Provisional; Region: PRK13455 391626001802 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 391626001803 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 391626001804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626001805 DNA-binding site [nucleotide binding]; DNA binding site 391626001806 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391626001807 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626001808 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626001809 ligand binding site [chemical binding]; other site 391626001810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626001811 Helix-turn-helix domain; Region: HTH_18; pfam12833 391626001812 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391626001813 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391626001814 DNA binding site [nucleotide binding] 391626001815 active site 391626001816 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391626001817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391626001818 minor groove reading motif; other site 391626001819 helix-hairpin-helix signature motif; other site 391626001820 substrate binding pocket [chemical binding]; other site 391626001821 active site 391626001822 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391626001823 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 391626001824 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626001825 substrate binding site [chemical binding]; other site 391626001826 ATP binding site [chemical binding]; other site 391626001827 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391626001828 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391626001829 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 391626001830 nucleotide binding site/active site [active] 391626001831 HIT family signature motif; other site 391626001832 catalytic residue [active] 391626001833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391626001834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626001835 Walker A/P-loop; other site 391626001836 ATP binding site [chemical binding]; other site 391626001837 Q-loop/lid; other site 391626001838 ABC transporter signature motif; other site 391626001839 Walker B; other site 391626001840 D-loop; other site 391626001841 H-loop/switch region; other site 391626001842 DNA polymerase I; Provisional; Region: PRK05755 391626001843 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391626001844 active site 391626001845 metal binding site 1 [ion binding]; metal-binding site 391626001846 putative 5' ssDNA interaction site; other site 391626001847 metal binding site 3; metal-binding site 391626001848 metal binding site 2 [ion binding]; metal-binding site 391626001849 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391626001850 putative DNA binding site [nucleotide binding]; other site 391626001851 putative metal binding site [ion binding]; other site 391626001852 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 391626001853 active site 391626001854 catalytic site [active] 391626001855 substrate binding site [chemical binding]; other site 391626001856 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391626001857 active site 391626001858 DNA binding site [nucleotide binding] 391626001859 catalytic site [active] 391626001860 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391626001861 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391626001862 putative dimer interface [polypeptide binding]; other site 391626001863 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391626001864 active site 391626001865 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 391626001866 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391626001867 Cysteine-rich domain; Region: CCG; pfam02754 391626001868 Cysteine-rich domain; Region: CCG; pfam02754 391626001869 FAD binding domain; Region: FAD_binding_4; pfam01565 391626001870 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 391626001871 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 391626001872 FAD binding domain; Region: FAD_binding_4; pfam01565 391626001873 Protein of unknown function, DUF599; Region: DUF599; pfam04654 391626001874 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 391626001875 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 391626001876 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391626001877 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 391626001878 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391626001879 Protein of unknown function DUF58; Region: DUF58; pfam01882 391626001880 MoxR-like ATPases [General function prediction only]; Region: COG0714 391626001881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626001882 Walker A motif; other site 391626001883 ATP binding site [chemical binding]; other site 391626001884 Walker B motif; other site 391626001885 arginine finger; other site 391626001886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816 391626001887 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 391626001888 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391626001889 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626001890 Predicted transcriptional regulator [Transcription]; Region: COG2378 391626001891 HTH domain; Region: HTH_11; pfam08279 391626001892 WYL domain; Region: WYL; pfam13280 391626001893 von Willebrand factor; Region: vWF_A; pfam12450 391626001894 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 391626001895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391626001896 metal ion-dependent adhesion site (MIDAS); other site 391626001897 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 391626001898 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 391626001899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626001900 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626001901 DNA binding residues [nucleotide binding] 391626001902 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 391626001903 succinic semialdehyde dehydrogenase; Region: PLN02278 391626001904 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391626001905 tetramerization interface [polypeptide binding]; other site 391626001906 NAD(P) binding site [chemical binding]; other site 391626001907 catalytic residues [active] 391626001908 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 391626001909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626001910 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 391626001911 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 391626001912 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 391626001913 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391626001914 putative NAD(P) binding site [chemical binding]; other site 391626001915 active site 391626001916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391626001917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391626001918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626001919 Walker A motif; other site 391626001920 ATP binding site [chemical binding]; other site 391626001921 Walker B motif; other site 391626001922 arginine finger; other site 391626001923 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 391626001924 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391626001925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626001926 NAD(P) binding site [chemical binding]; other site 391626001927 catalytic residues [active] 391626001928 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391626001929 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391626001930 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391626001931 intersubunit interface [polypeptide binding]; other site 391626001932 active site 391626001933 catalytic residue [active] 391626001934 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 391626001935 Helix-turn-helix domain; Region: HTH_18; pfam12833 391626001936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626001937 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 391626001938 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 391626001939 substrate binding site [chemical binding]; other site 391626001940 hexamer interface [polypeptide binding]; other site 391626001941 metal binding site [ion binding]; metal-binding site 391626001942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626001943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626001944 NAD(P) binding site [chemical binding]; other site 391626001945 active site 391626001946 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391626001947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626001948 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626001949 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626001950 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626001951 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626001952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626001953 kynureninase; Region: kynureninase; TIGR01814 391626001954 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626001955 catalytic residue [active] 391626001956 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391626001957 Sulfatase; Region: Sulfatase; cl17466 391626001958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626001959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626001960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626001961 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391626001962 intersubunit interface [polypeptide binding]; other site 391626001963 active site 391626001964 zinc binding site [ion binding]; other site 391626001965 Na+ binding site [ion binding]; other site 391626001966 KduI/IolB family; Region: KduI; pfam04962 391626001967 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626001968 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391626001969 substrate binding site [chemical binding]; other site 391626001970 ATP binding site [chemical binding]; other site 391626001971 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391626001972 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391626001973 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626001974 dimer interface [polypeptide binding]; other site 391626001975 PYR/PP interface [polypeptide binding]; other site 391626001976 TPP binding site [chemical binding]; other site 391626001977 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626001978 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626001979 TPP-binding site [chemical binding]; other site 391626001980 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626001981 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626001982 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626001983 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391626001984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626001985 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626001986 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626001987 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626001988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626001989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626001990 DNA binding site [nucleotide binding] 391626001991 domain linker motif; other site 391626001992 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391626001993 putative dimerization interface [polypeptide binding]; other site 391626001994 putative ligand binding site [chemical binding]; other site 391626001995 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391626001996 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626001997 putative ligand binding site [chemical binding]; other site 391626001998 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626001999 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626002000 TM-ABC transporter signature motif; other site 391626002001 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626002002 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626002003 Walker A/P-loop; other site 391626002004 ATP binding site [chemical binding]; other site 391626002005 Q-loop/lid; other site 391626002006 ABC transporter signature motif; other site 391626002007 Walker B; other site 391626002008 D-loop; other site 391626002009 H-loop/switch region; other site 391626002010 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391626002011 Family description; Region: VCBS; pfam13517 391626002012 Family description; Region: VCBS; pfam13517 391626002013 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 391626002014 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391626002015 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391626002016 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391626002017 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 391626002018 putative ligand binding site [chemical binding]; other site 391626002019 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626002020 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626002021 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626002022 TM-ABC transporter signature motif; other site 391626002023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626002024 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626002025 Walker A/P-loop; other site 391626002026 ATP binding site [chemical binding]; other site 391626002027 Q-loop/lid; other site 391626002028 ABC transporter signature motif; other site 391626002029 Walker B; other site 391626002030 D-loop; other site 391626002031 H-loop/switch region; other site 391626002032 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 391626002033 N- and C-terminal domain interface [polypeptide binding]; other site 391626002034 D-xylulose kinase; Region: XylB; TIGR01312 391626002035 active site 391626002036 MgATP binding site [chemical binding]; other site 391626002037 catalytic site [active] 391626002038 metal binding site [ion binding]; metal-binding site 391626002039 xylulose binding site [chemical binding]; other site 391626002040 homodimer interface [polypeptide binding]; other site 391626002041 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391626002042 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391626002043 ligand binding site [chemical binding]; other site 391626002044 flexible hinge region; other site 391626002045 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391626002046 putative switch regulator; other site 391626002047 non-specific DNA interactions [nucleotide binding]; other site 391626002048 DNA binding site [nucleotide binding] 391626002049 sequence specific DNA binding site [nucleotide binding]; other site 391626002050 putative cAMP binding site [chemical binding]; other site 391626002051 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 391626002052 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391626002053 Multicopper oxidase; Region: Cu-oxidase; pfam00394 391626002054 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391626002055 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 391626002056 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 391626002057 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626002058 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391626002059 putative ligand binding site [chemical binding]; other site 391626002060 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626002061 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626002062 TM-ABC transporter signature motif; other site 391626002063 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626002064 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626002065 TM-ABC transporter signature motif; other site 391626002066 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391626002067 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626002068 Walker A/P-loop; other site 391626002069 ATP binding site [chemical binding]; other site 391626002070 Q-loop/lid; other site 391626002071 ABC transporter signature motif; other site 391626002072 Walker B; other site 391626002073 D-loop; other site 391626002074 H-loop/switch region; other site 391626002075 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391626002076 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626002077 Walker A/P-loop; other site 391626002078 ATP binding site [chemical binding]; other site 391626002079 Q-loop/lid; other site 391626002080 ABC transporter signature motif; other site 391626002081 Walker B; other site 391626002082 D-loop; other site 391626002083 H-loop/switch region; other site 391626002084 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626002085 Transposase; Region: HTH_Tnp_1; cl17663 391626002086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626002087 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626002088 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626002089 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626002090 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626002091 cytosine deaminase; Validated; Region: PRK07572 391626002092 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 391626002093 active site 391626002094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626002095 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626002096 TM-ABC transporter signature motif; other site 391626002097 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626002098 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626002099 TM-ABC transporter signature motif; other site 391626002100 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391626002101 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626002102 Q-loop/lid; other site 391626002103 ABC transporter signature motif; other site 391626002104 Walker B; other site 391626002105 D-loop; other site 391626002106 H-loop/switch region; other site 391626002107 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626002108 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391626002109 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391626002110 putative ligand binding site [chemical binding]; other site 391626002111 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626002112 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 391626002113 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 391626002114 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391626002115 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 391626002116 LytTr DNA-binding domain; Region: LytTR; smart00850 391626002117 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391626002118 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391626002119 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391626002120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626002121 catalytic loop [active] 391626002122 iron binding site [ion binding]; other site 391626002123 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626002124 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 391626002125 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 391626002126 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626002127 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391626002128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002129 Walker A motif; other site 391626002130 ATP binding site [chemical binding]; other site 391626002131 Walker B motif; other site 391626002132 arginine finger; other site 391626002133 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391626002134 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391626002135 metal ion-dependent adhesion site (MIDAS); other site 391626002136 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391626002137 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391626002138 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391626002139 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391626002140 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391626002141 Ligand binding site; other site 391626002142 metal-binding site 391626002143 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391626002144 putative hydrophobic ligand binding site [chemical binding]; other site 391626002145 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391626002146 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391626002147 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391626002148 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391626002149 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391626002150 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391626002151 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626002152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626002153 Walker A/P-loop; other site 391626002154 ATP binding site [chemical binding]; other site 391626002155 Q-loop/lid; other site 391626002156 ABC transporter signature motif; other site 391626002157 Walker B; other site 391626002158 D-loop; other site 391626002159 H-loop/switch region; other site 391626002160 TOBE domain; Region: TOBE_2; pfam08402 391626002161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626002162 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626002163 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626002164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002165 dimer interface [polypeptide binding]; other site 391626002166 conserved gate region; other site 391626002167 putative PBP binding loops; other site 391626002168 ABC-ATPase subunit interface; other site 391626002169 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626002170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002171 dimer interface [polypeptide binding]; other site 391626002172 conserved gate region; other site 391626002173 putative PBP binding loops; other site 391626002174 ABC-ATPase subunit interface; other site 391626002175 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391626002176 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626002177 active site 391626002178 metal binding site [ion binding]; metal-binding site 391626002179 hexamer interface [polypeptide binding]; other site 391626002180 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 391626002181 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391626002182 active site 391626002183 ParB-like nuclease domain; Region: ParBc; pfam02195 391626002184 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391626002185 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391626002186 DNA methylase; Region: N6_N4_Mtase; pfam01555 391626002187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410 391626002188 Terminase-like family; Region: Terminase_6; pfam03237 391626002189 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 391626002190 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626002191 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626002192 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391626002193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626002194 Integrase core domain; Region: rve; pfam00665 391626002195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626002196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626002197 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 391626002198 putative substrate binding pocket [chemical binding]; other site 391626002199 dimerization interface [polypeptide binding]; other site 391626002200 hypothetical protein; Provisional; Region: PRK12569 391626002201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391626002202 carboxyltransferase (CT) interaction site; other site 391626002203 biotinylation site [posttranslational modification]; other site 391626002204 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391626002205 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626002206 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626002207 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391626002208 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 391626002209 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 391626002210 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 391626002211 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 391626002212 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 391626002213 putative ligand binding site [chemical binding]; other site 391626002214 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626002215 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626002216 Walker A/P-loop; other site 391626002217 ATP binding site [chemical binding]; other site 391626002218 Q-loop/lid; other site 391626002219 ABC transporter signature motif; other site 391626002220 Walker B; other site 391626002221 D-loop; other site 391626002222 H-loop/switch region; other site 391626002223 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626002224 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626002225 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626002226 TM-ABC transporter signature motif; other site 391626002227 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 391626002228 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391626002229 inhibitor-cofactor binding pocket; inhibition site 391626002230 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626002231 catalytic residue [active] 391626002232 succinic semialdehyde dehydrogenase; Region: PLN02278 391626002233 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391626002234 tetramerization interface [polypeptide binding]; other site 391626002235 NAD(P) binding site [chemical binding]; other site 391626002236 catalytic residues [active] 391626002237 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391626002238 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391626002239 Walker A/P-loop; other site 391626002240 ATP binding site [chemical binding]; other site 391626002241 Q-loop/lid; other site 391626002242 ABC transporter signature motif; other site 391626002243 Walker B; other site 391626002244 D-loop; other site 391626002245 H-loop/switch region; other site 391626002246 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 391626002247 BioY family; Region: BioY; pfam02632 391626002248 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 391626002249 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391626002250 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391626002251 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626002252 catalytic loop [active] 391626002253 iron binding site [ion binding]; other site 391626002254 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626002255 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391626002256 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626002257 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626002258 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 391626002259 putative FMN binding site [chemical binding]; other site 391626002260 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 391626002261 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391626002262 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 391626002263 acyl-activating enzyme (AAE) consensus motif; other site 391626002264 AMP binding site [chemical binding]; other site 391626002265 active site 391626002266 CoA binding site [chemical binding]; other site 391626002267 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 391626002268 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626002269 dimer interface [polypeptide binding]; other site 391626002270 active site 391626002271 ParB-like nuclease domain; Region: ParBc; pfam02195 391626002272 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391626002273 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391626002274 DNA methylase; Region: N6_N4_Mtase; pfam01555 391626002275 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626002276 Integrase core domain; Region: rve; pfam00665 391626002277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626002278 ATP binding site [chemical binding]; other site 391626002279 Mg2+ binding site [ion binding]; other site 391626002280 G-X-G motif; other site 391626002281 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 391626002282 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 391626002283 AAA domain; Region: AAA_30; pfam13604 391626002284 Family description; Region: UvrD_C_2; pfam13538 391626002285 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391626002286 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 391626002287 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391626002288 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391626002289 catalytic residues [active] 391626002290 catalytic nucleophile [active] 391626002291 Presynaptic Site I dimer interface [polypeptide binding]; other site 391626002292 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391626002293 Synaptic Flat tetramer interface [polypeptide binding]; other site 391626002294 Synaptic Site I dimer interface [polypeptide binding]; other site 391626002295 DNA binding site [nucleotide binding] 391626002296 Recombinase; Region: Recombinase; pfam07508 391626002297 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 391626002298 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391626002299 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 391626002300 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 391626002301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626002302 Walker A/P-loop; other site 391626002303 ATP binding site [chemical binding]; other site 391626002304 Q-loop/lid; other site 391626002305 ABC transporter signature motif; other site 391626002306 Walker B; other site 391626002307 D-loop; other site 391626002308 H-loop/switch region; other site 391626002309 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 391626002310 ligand binding site [chemical binding]; other site 391626002311 active site 391626002312 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 391626002313 putative ligand binding site [chemical binding]; other site 391626002314 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391626002315 NAD binding site [chemical binding]; other site 391626002316 dimerization interface [polypeptide binding]; other site 391626002317 catalytic site [active] 391626002318 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 391626002319 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391626002320 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391626002321 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391626002322 rod shape-determining protein MreC; Provisional; Region: PRK13922 391626002323 rod shape-determining protein MreC; Region: MreC; pfam04085 391626002324 rod shape-determining protein MreB; Provisional; Region: PRK13927 391626002325 MreB and similar proteins; Region: MreB_like; cd10225 391626002326 nucleotide binding site [chemical binding]; other site 391626002327 Mg binding site [ion binding]; other site 391626002328 putative protofilament interaction site [polypeptide binding]; other site 391626002329 RodZ interaction site [polypeptide binding]; other site 391626002330 2-isopropylmalate synthase; Validated; Region: PRK00915 391626002331 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 391626002332 active site 391626002333 catalytic residues [active] 391626002334 metal binding site [ion binding]; metal-binding site 391626002335 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391626002336 C factor cell-cell signaling protein; Provisional; Region: PRK09009 391626002337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626002338 NAD(P) binding site [chemical binding]; other site 391626002339 active site 391626002340 EthD domain; Region: EthD; cl17553 391626002341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391626002342 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391626002343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391626002344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391626002345 NAD synthetase; Provisional; Region: PRK13981 391626002346 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391626002347 multimer interface [polypeptide binding]; other site 391626002348 active site 391626002349 catalytic triad [active] 391626002350 protein interface 1 [polypeptide binding]; other site 391626002351 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 391626002352 homodimer interface [polypeptide binding]; other site 391626002353 NAD binding pocket [chemical binding]; other site 391626002354 ATP binding pocket [chemical binding]; other site 391626002355 Mg binding site [ion binding]; other site 391626002356 active-site loop [active] 391626002357 large tegument protein UL36; Provisional; Region: PHA03246 391626002358 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391626002359 Peptidase family M23; Region: Peptidase_M23; pfam01551 391626002360 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 391626002361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002362 Walker A motif; other site 391626002363 ATP binding site [chemical binding]; other site 391626002364 Walker B motif; other site 391626002365 arginine finger; other site 391626002366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002367 Walker A motif; other site 391626002368 ATP binding site [chemical binding]; other site 391626002369 Walker B motif; other site 391626002370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391626002371 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 391626002372 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391626002373 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391626002374 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 391626002375 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 391626002376 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391626002377 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391626002378 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391626002379 beta subunit interaction interface [polypeptide binding]; other site 391626002380 Walker A motif; other site 391626002381 ATP binding site [chemical binding]; other site 391626002382 Walker B motif; other site 391626002383 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391626002384 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 391626002385 core domain interface [polypeptide binding]; other site 391626002386 delta subunit interface [polypeptide binding]; other site 391626002387 epsilon subunit interface [polypeptide binding]; other site 391626002388 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391626002389 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391626002390 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391626002391 alpha subunit interaction interface [polypeptide binding]; other site 391626002392 Walker A motif; other site 391626002393 ATP binding site [chemical binding]; other site 391626002394 Walker B motif; other site 391626002395 inhibitor binding site; inhibition site 391626002396 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391626002397 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 391626002398 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391626002399 gamma subunit interface [polypeptide binding]; other site 391626002400 epsilon subunit interface [polypeptide binding]; other site 391626002401 LBP interface [polypeptide binding]; other site 391626002402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626002403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626002404 putative substrate translocation pore; other site 391626002405 H-type lectin domain; Region: H_lectin; pfam09458 391626002406 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 391626002407 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391626002408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626002409 active site 391626002410 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 391626002411 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 391626002412 putative catalytic residue [active] 391626002413 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 391626002414 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391626002415 tetramer interface [polypeptide binding]; other site 391626002416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626002417 catalytic residue [active] 391626002418 hypothetical protein; Provisional; Region: PRK05170 391626002419 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391626002420 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391626002421 active site 391626002422 Riboflavin kinase; Region: Flavokinase; pfam01687 391626002423 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 391626002424 dimer interaction site [polypeptide binding]; other site 391626002425 substrate-binding tunnel; other site 391626002426 active site 391626002427 catalytic site [active] 391626002428 substrate binding site [chemical binding]; other site 391626002429 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 391626002430 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 391626002431 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391626002432 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 391626002433 DHH family; Region: DHH; pfam01368 391626002434 DHHA2 domain; Region: DHHA2; pfam02833 391626002435 Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929 391626002436 TraB family; Region: TraB; pfam01963 391626002437 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391626002438 oligomerisation interface [polypeptide binding]; other site 391626002439 mobile loop; other site 391626002440 roof hairpin; other site 391626002441 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391626002442 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391626002443 ring oligomerisation interface [polypeptide binding]; other site 391626002444 ATP/Mg binding site [chemical binding]; other site 391626002445 stacking interactions; other site 391626002446 hinge regions; other site 391626002447 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391626002448 nudix motif; other site 391626002449 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 391626002450 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391626002451 ATP-grasp domain; Region: ATP-grasp; pfam02222 391626002452 AIR carboxylase; Region: AIRC; pfam00731 391626002453 Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481 391626002454 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391626002455 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391626002456 putative dimer interface [polypeptide binding]; other site 391626002457 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 391626002458 Integrase core domain; Region: rve_3; cl15866 391626002459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 391626002460 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 391626002461 ATP-sulfurylase; Region: ATPS; cd00517 391626002462 active site 391626002463 HXXH motif; other site 391626002464 flexible loop; other site 391626002465 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 391626002466 ligand-binding site [chemical binding]; other site 391626002467 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391626002468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626002469 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626002470 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626002471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626002472 putative DNA binding site [nucleotide binding]; other site 391626002473 putative Zn2+ binding site [ion binding]; other site 391626002474 AsnC family; Region: AsnC_trans_reg; pfam01037 391626002475 Hint domain; Region: Hint_2; pfam13403 391626002476 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 391626002477 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 391626002478 Uncharacterized conserved protein [Function unknown]; Region: COG1565 391626002479 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 391626002480 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 391626002481 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626002482 active site 391626002483 HIGH motif; other site 391626002484 nucleotide binding site [chemical binding]; other site 391626002485 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391626002486 active site 391626002487 KMSKS motif; other site 391626002488 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 391626002489 tRNA binding surface [nucleotide binding]; other site 391626002490 anticodon binding site; other site 391626002491 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391626002492 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 391626002493 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391626002494 DNA binding site [nucleotide binding] 391626002495 active site 391626002496 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391626002497 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391626002498 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391626002499 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626002500 active site 391626002501 DNA binding site [nucleotide binding] 391626002502 Int/Topo IB signature motif; other site 391626002503 Protein of unknown function, DUF484; Region: DUF484; cl17449 391626002504 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 391626002505 active site 391626002506 intersubunit interactions; other site 391626002507 catalytic residue [active] 391626002508 LysE type translocator; Region: LysE; cl00565 391626002509 primosome assembly protein PriA; Validated; Region: PRK05580 391626002510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626002511 ATP binding site [chemical binding]; other site 391626002512 putative Mg++ binding site [ion binding]; other site 391626002513 nucleotide binding region [chemical binding]; other site 391626002514 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391626002515 ATP-binding site [chemical binding]; other site 391626002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626002517 putative substrate translocation pore; other site 391626002518 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 391626002519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626002520 S-adenosylmethionine binding site [chemical binding]; other site 391626002521 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391626002522 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 391626002523 active site 391626002524 putative DNA-binding cleft [nucleotide binding]; other site 391626002525 dimer interface [polypeptide binding]; other site 391626002526 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391626002527 RuvA N terminal domain; Region: RuvA_N; pfam01330 391626002528 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 391626002529 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391626002530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002531 Walker A motif; other site 391626002532 ATP binding site [chemical binding]; other site 391626002533 Walker B motif; other site 391626002534 arginine finger; other site 391626002535 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391626002536 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391626002537 active site 391626002538 TolQ protein; Region: tolQ; TIGR02796 391626002539 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 391626002540 TolR protein; Region: tolR; TIGR02801 391626002541 translocation protein TolB; Provisional; Region: tolB; PRK05137 391626002542 TolB amino-terminal domain; Region: TolB_N; pfam04052 391626002543 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391626002544 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391626002545 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391626002546 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626002547 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626002548 ligand binding site [chemical binding]; other site 391626002549 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 391626002550 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 391626002551 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391626002552 FtsH Extracellular; Region: FtsH_ext; pfam06480 391626002553 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391626002554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002555 Walker A motif; other site 391626002556 ATP binding site [chemical binding]; other site 391626002557 Walker B motif; other site 391626002558 arginine finger; other site 391626002559 Peptidase family M41; Region: Peptidase_M41; pfam01434 391626002560 MOSC domain; Region: MOSC; pfam03473 391626002561 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 391626002562 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 391626002563 Potassium binding sites [ion binding]; other site 391626002564 Cesium cation binding sites [ion binding]; other site 391626002565 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 391626002566 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391626002567 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391626002568 homodimer interface [polypeptide binding]; other site 391626002569 NADP binding site [chemical binding]; other site 391626002570 substrate binding site [chemical binding]; other site 391626002571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626002572 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 391626002573 putative active site [active] 391626002574 putative metal binding site [ion binding]; other site 391626002575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391626002576 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626002577 nucleotide binding region [chemical binding]; other site 391626002578 ATP-binding site [chemical binding]; other site 391626002579 DEAD/H associated; Region: DEAD_assoc; pfam08494 391626002580 RNA helicase; Region: RNA_helicase; pfam00910 391626002581 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 391626002582 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 391626002583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626002584 binding surface 391626002585 TPR motif; other site 391626002586 TPR repeat; Region: TPR_11; pfam13414 391626002587 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 391626002588 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 391626002589 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391626002590 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 391626002591 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391626002592 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 391626002593 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 391626002594 ATP binding site [chemical binding]; other site 391626002595 Walker A motif; other site 391626002596 hexamer interface [polypeptide binding]; other site 391626002597 Walker B motif; other site 391626002598 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391626002599 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 391626002600 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391626002601 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626002602 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626002603 ligand binding site [chemical binding]; other site 391626002604 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 391626002605 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 391626002606 BON domain; Region: BON; pfam04972 391626002607 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 391626002608 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 391626002609 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391626002610 Haloacid Dehalogenase Superfamily Class (subfamily) IIA; Region: HAD-SF-IIA; TIGR01460 391626002611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626002612 motif I; other site 391626002613 motif II; other site 391626002614 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391626002615 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391626002616 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391626002617 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391626002618 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626002619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626002620 Walker A/P-loop; other site 391626002621 ATP binding site [chemical binding]; other site 391626002622 Q-loop/lid; other site 391626002623 ABC transporter signature motif; other site 391626002624 Walker B; other site 391626002625 D-loop; other site 391626002626 H-loop/switch region; other site 391626002627 TOBE domain; Region: TOBE_2; pfam08402 391626002628 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626002629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626002630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002631 dimer interface [polypeptide binding]; other site 391626002632 conserved gate region; other site 391626002633 putative PBP binding loops; other site 391626002634 ABC-ATPase subunit interface; other site 391626002635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626002636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002637 dimer interface [polypeptide binding]; other site 391626002638 conserved gate region; other site 391626002639 putative PBP binding loops; other site 391626002640 ABC-ATPase subunit interface; other site 391626002641 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391626002642 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626002643 active site 391626002644 metal binding site [ion binding]; metal-binding site 391626002645 hexamer interface [polypeptide binding]; other site 391626002646 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 391626002647 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 391626002648 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391626002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002650 dimer interface [polypeptide binding]; other site 391626002651 conserved gate region; other site 391626002652 putative PBP binding loops; other site 391626002653 ABC-ATPase subunit interface; other site 391626002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002655 dimer interface [polypeptide binding]; other site 391626002656 conserved gate region; other site 391626002657 putative PBP binding loops; other site 391626002658 ABC-ATPase subunit interface; other site 391626002659 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626002660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626002661 Walker A/P-loop; other site 391626002662 ATP binding site [chemical binding]; other site 391626002663 Q-loop/lid; other site 391626002664 ABC transporter signature motif; other site 391626002665 Walker B; other site 391626002666 D-loop; other site 391626002667 H-loop/switch region; other site 391626002668 TOBE domain; Region: TOBE_2; pfam08402 391626002669 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391626002670 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391626002671 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391626002672 non-specific DNA interactions [nucleotide binding]; other site 391626002673 DNA binding site [nucleotide binding] 391626002674 sequence specific DNA binding site [nucleotide binding]; other site 391626002675 putative cAMP binding site [chemical binding]; other site 391626002676 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391626002677 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391626002678 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 391626002679 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 391626002680 ligand binding site; other site 391626002681 tetramer interface; other site 391626002682 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 391626002683 NeuB family; Region: NeuB; pfam03102 391626002684 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 391626002685 NeuB binding interface [polypeptide binding]; other site 391626002686 putative substrate binding site [chemical binding]; other site 391626002687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626002688 FAD dependent oxidoreductase; Region: DAO; pfam01266 391626002689 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391626002690 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391626002691 inhibitor-cofactor binding pocket; inhibition site 391626002692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626002693 catalytic residue [active] 391626002694 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 391626002695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626002696 NAD(P) binding site [chemical binding]; other site 391626002697 active site 391626002698 Immunoglobulin domain; Region: Ig; cl11960 391626002699 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391626002700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626002701 dimer interface [polypeptide binding]; other site 391626002702 phosphorylation site [posttranslational modification] 391626002703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626002704 ATP binding site [chemical binding]; other site 391626002705 Mg2+ binding site [ion binding]; other site 391626002706 G-X-G motif; other site 391626002707 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391626002708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626002709 active site 391626002710 phosphorylation site [posttranslational modification] 391626002711 intermolecular recognition site; other site 391626002712 dimerization interface [polypeptide binding]; other site 391626002713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002714 Walker A motif; other site 391626002715 ATP binding site [chemical binding]; other site 391626002716 Walker B motif; other site 391626002717 arginine finger; other site 391626002718 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391626002719 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391626002720 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391626002721 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391626002722 DctM-like transporters; Region: DctM; pfam06808 391626002723 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391626002724 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391626002725 putative dimer interface [polypeptide binding]; other site 391626002726 N-terminal domain interface [polypeptide binding]; other site 391626002727 putative substrate binding pocket (H-site) [chemical binding]; other site 391626002728 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 391626002729 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391626002730 ABC-ATPase subunit interface; other site 391626002731 dimer interface [polypeptide binding]; other site 391626002732 putative PBP binding regions; other site 391626002733 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 391626002734 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 391626002735 putative ligand binding residues [chemical binding]; other site 391626002736 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391626002737 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391626002738 Walker A/P-loop; other site 391626002739 ATP binding site [chemical binding]; other site 391626002740 Q-loop/lid; other site 391626002741 ABC transporter signature motif; other site 391626002742 Walker B; other site 391626002743 D-loop; other site 391626002744 H-loop/switch region; other site 391626002745 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391626002746 Transposase; Region: HTH_Tnp_1; cl17663 391626002747 transcriptional repressor DicA; Reviewed; Region: PRK09706 391626002748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626002749 non-specific DNA binding site [nucleotide binding]; other site 391626002750 salt bridge; other site 391626002751 sequence-specific DNA binding site [nucleotide binding]; other site 391626002752 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391626002753 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626002754 NAD binding site [chemical binding]; other site 391626002755 catalytic residues [active] 391626002756 phosphoglucomutase; Region: PLN02307 391626002757 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 391626002758 active site 391626002759 substrate binding site [chemical binding]; other site 391626002760 metal binding site [ion binding]; metal-binding site 391626002761 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 391626002762 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 391626002763 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 391626002764 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 391626002765 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 391626002766 active site 391626002767 catalytic site [active] 391626002768 glycogen synthase; Provisional; Region: glgA; PRK00654 391626002769 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 391626002770 ADP-binding pocket [chemical binding]; other site 391626002771 homodimer interface [polypeptide binding]; other site 391626002772 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 391626002773 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 391626002774 ligand binding site; other site 391626002775 oligomer interface; other site 391626002776 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 391626002777 dimer interface [polypeptide binding]; other site 391626002778 N-terminal domain interface [polypeptide binding]; other site 391626002779 sulfate 1 binding site; other site 391626002780 glycogen branching enzyme; Provisional; Region: PRK05402 391626002781 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 391626002782 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 391626002783 active site 391626002784 catalytic site [active] 391626002785 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 391626002786 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 391626002787 homodimer interface [polypeptide binding]; other site 391626002788 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 391626002789 active site pocket [active] 391626002790 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391626002791 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391626002792 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 391626002793 active site 391626002794 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626002795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626002796 Walker A/P-loop; other site 391626002797 ATP binding site [chemical binding]; other site 391626002798 Q-loop/lid; other site 391626002799 ABC transporter signature motif; other site 391626002800 Walker B; other site 391626002801 D-loop; other site 391626002802 H-loop/switch region; other site 391626002803 TOBE domain; Region: TOBE_2; pfam08402 391626002804 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626002805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002806 dimer interface [polypeptide binding]; other site 391626002807 putative PBP binding loops; other site 391626002808 ABC-ATPase subunit interface; other site 391626002809 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626002810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002811 dimer interface [polypeptide binding]; other site 391626002812 conserved gate region; other site 391626002813 putative PBP binding loops; other site 391626002814 ABC-ATPase subunit interface; other site 391626002815 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 391626002816 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391626002817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626002818 Family of unknown function (DUF490); Region: DUF490; pfam04357 391626002819 Family of unknown function (DUF490); Region: DUF490; pfam04357 391626002820 Surface antigen; Region: Bac_surface_Ag; pfam01103 391626002821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626002822 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391626002823 active site 391626002824 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391626002825 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 391626002826 dimerization interface 3.5A [polypeptide binding]; other site 391626002827 active site 391626002828 YcjX-like family, DUF463; Region: DUF463; pfam04317 391626002829 hypothetical protein; Provisional; Region: PRK05415 391626002830 Domain of unknown function (DUF697); Region: DUF697; pfam05128 391626002831 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 391626002832 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 391626002833 oligomer interface [polypeptide binding]; other site 391626002834 active site 391626002835 metal binding site [ion binding]; metal-binding site 391626002836 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 391626002837 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391626002838 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391626002839 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 391626002840 dimer interface [polypeptide binding]; other site 391626002841 putative tRNA-binding site [nucleotide binding]; other site 391626002842 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391626002843 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391626002844 dimerization interface [polypeptide binding]; other site 391626002845 ligand binding site [chemical binding]; other site 391626002846 NADP binding site [chemical binding]; other site 391626002847 catalytic site [active] 391626002848 thymidine kinase; Provisional; Region: PRK04296 391626002849 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391626002850 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626002851 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 391626002852 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391626002853 dimer interface [polypeptide binding]; other site 391626002854 active site 391626002855 CoA binding pocket [chemical binding]; other site 391626002856 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 391626002857 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391626002858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626002859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626002860 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391626002861 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626002862 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626002863 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391626002864 IMP binding site; other site 391626002865 dimer interface [polypeptide binding]; other site 391626002866 interdomain contacts; other site 391626002867 partial ornithine binding site; other site 391626002868 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391626002869 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391626002870 dimer interface [polypeptide binding]; other site 391626002871 anticodon binding site; other site 391626002872 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391626002873 motif 1; other site 391626002874 dimer interface [polypeptide binding]; other site 391626002875 active site 391626002876 motif 2; other site 391626002877 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391626002878 active site 391626002879 motif 3; other site 391626002880 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 391626002881 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 391626002882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626002883 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626002884 Response regulator receiver domain; Region: Response_reg; pfam00072 391626002885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626002886 active site 391626002887 phosphorylation site [posttranslational modification] 391626002888 intermolecular recognition site; other site 391626002889 dimerization interface [polypeptide binding]; other site 391626002890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626002891 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391626002892 dimer interface [polypeptide binding]; other site 391626002893 substrate binding site [chemical binding]; other site 391626002894 metal binding site [ion binding]; metal-binding site 391626002895 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 391626002896 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626002897 putative metal binding site [ion binding]; other site 391626002898 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 391626002899 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 391626002900 putative FMN binding site [chemical binding]; other site 391626002901 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391626002902 homotrimer interaction site [polypeptide binding]; other site 391626002903 putative active site [active] 391626002904 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391626002905 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391626002906 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391626002907 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391626002908 Domain of unknown function DUF302; Region: DUF302; pfam03625 391626002909 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 391626002910 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391626002911 active site 391626002912 Zn binding site [ion binding]; other site 391626002913 Peptidase family M48; Region: Peptidase_M48; cl12018 391626002914 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 391626002915 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 391626002916 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 391626002917 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 391626002918 active site 391626002919 Zn binding site [ion binding]; other site 391626002920 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391626002921 trimer interface [polypeptide binding]; other site 391626002922 active site 391626002923 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 391626002924 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391626002925 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626002926 FeS/SAM binding site; other site 391626002927 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626002928 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626002929 Pirin-related protein [General function prediction only]; Region: COG1741 391626002930 Pirin; Region: Pirin; pfam02678 391626002931 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 391626002932 putative transposase OrfB; Reviewed; Region: PHA02517 391626002933 HTH-like domain; Region: HTH_21; pfam13276 391626002934 Integrase core domain; Region: rve; pfam00665 391626002935 Integrase core domain; Region: rve_3; cl15866 391626002936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626002937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626002938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626002939 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626002940 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626002941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626002942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626002943 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391626002944 dimerization interface [polypeptide binding]; other site 391626002945 hypothetical protein; Provisional; Region: PRK05463 391626002946 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626002947 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626002948 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626002949 DctM-like transporters; Region: DctM; pfam06808 391626002950 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626002951 5-oxoprolinase; Region: PLN02666 391626002952 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626002953 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391626002954 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391626002955 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 391626002956 cyanate hydratase; Validated; Region: PRK02866 391626002957 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 391626002958 oligomer interface [polypeptide binding]; other site 391626002959 active site 391626002960 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 391626002961 SnoaL-like domain; Region: SnoaL_2; pfam12680 391626002962 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391626002963 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626002964 Walker A/P-loop; other site 391626002965 ATP binding site [chemical binding]; other site 391626002966 Q-loop/lid; other site 391626002967 ABC transporter signature motif; other site 391626002968 Walker B; other site 391626002969 D-loop; other site 391626002970 H-loop/switch region; other site 391626002971 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626002972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626002973 dimer interface [polypeptide binding]; other site 391626002974 conserved gate region; other site 391626002975 putative PBP binding loops; other site 391626002976 ABC-ATPase subunit interface; other site 391626002977 NMT1-like family; Region: NMT1_2; pfam13379 391626002978 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391626002979 PAS domain; Region: PAS_9; pfam13426 391626002980 PAS domain S-box; Region: sensory_box; TIGR00229 391626002981 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626002982 putative active site [active] 391626002983 heme pocket [chemical binding]; other site 391626002984 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 391626002985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626002986 Walker A motif; other site 391626002987 ATP binding site [chemical binding]; other site 391626002988 Walker B motif; other site 391626002989 arginine finger; other site 391626002990 Transposase; Region: HTH_Tnp_1; pfam01527 391626002991 Transposase domain (DUF772); Region: DUF772; pfam05598 391626002992 Transposase; Region: HTH_Tnp_1; cl17663 391626002993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626002994 AAA ATPase domain; Region: AAA_16; pfam13191 391626002995 Transposase; Region: HTH_Tnp_1; pfam01527 391626002996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626002997 Imelysin; Region: Peptidase_M75; cl09159 391626002998 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 391626002999 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 391626003000 Imelysin; Region: Peptidase_M75; pfam09375 391626003001 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 391626003002 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 391626003003 Hemin uptake protein hemP; Region: hemP; pfam10636 391626003004 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391626003005 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391626003006 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391626003007 active site 391626003008 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 391626003009 Predicted membrane protein [Function unknown]; Region: COG3748 391626003010 Protein of unknown function (DUF989); Region: DUF989; pfam06181 391626003011 Cytochrome c; Region: Cytochrom_C; pfam00034 391626003012 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626003013 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626003014 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626003015 putative effector binding pocket; other site 391626003016 dimerization interface [polypeptide binding]; other site 391626003017 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 391626003018 active site 391626003019 homotetramer interface [polypeptide binding]; other site 391626003020 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391626003021 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391626003022 active site 391626003023 catalytic site [active] 391626003024 tetramer interface [polypeptide binding]; other site 391626003025 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 391626003026 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 391626003027 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 391626003028 xanthine permease; Region: pbuX; TIGR03173 391626003029 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391626003030 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 391626003031 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391626003032 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391626003033 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 391626003034 dimer interface [polypeptide binding]; other site 391626003035 active site 391626003036 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391626003037 substrate binding site [chemical binding]; other site 391626003038 catalytic residue [active] 391626003039 serine racemase; Region: PLN02970 391626003040 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391626003041 tetramer interface [polypeptide binding]; other site 391626003042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626003043 catalytic residue [active] 391626003044 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 391626003045 homodimer interface [polypeptide binding]; other site 391626003046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626003047 catalytic residue [active] 391626003048 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391626003049 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391626003050 Bacterial transcriptional regulator; Region: IclR; pfam01614 391626003051 hypothetical protein; Provisional; Region: PRK11171 391626003052 Cupin domain; Region: Cupin_2; pfam07883 391626003053 Cupin domain; Region: Cupin_2; pfam07883 391626003054 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626003055 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626003056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391626003057 non-specific DNA binding site [nucleotide binding]; other site 391626003058 salt bridge; other site 391626003059 sequence-specific DNA binding site [nucleotide binding]; other site 391626003060 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391626003061 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626003062 DNA binding residues [nucleotide binding] 391626003063 dimerization interface [polypeptide binding]; other site 391626003064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626003065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626003066 dimer interface [polypeptide binding]; other site 391626003067 conserved gate region; other site 391626003068 putative PBP binding loops; other site 391626003069 ABC-ATPase subunit interface; other site 391626003070 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626003071 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391626003072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626003073 dimer interface [polypeptide binding]; other site 391626003074 conserved gate region; other site 391626003075 putative PBP binding loops; other site 391626003076 ABC-ATPase subunit interface; other site 391626003077 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391626003078 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626003079 Walker A/P-loop; other site 391626003080 ATP binding site [chemical binding]; other site 391626003081 Q-loop/lid; other site 391626003082 ABC transporter signature motif; other site 391626003083 Walker B; other site 391626003084 D-loop; other site 391626003085 H-loop/switch region; other site 391626003086 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626003087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626003088 Walker A/P-loop; other site 391626003089 ATP binding site [chemical binding]; other site 391626003090 Q-loop/lid; other site 391626003091 ABC transporter signature motif; other site 391626003092 Walker B; other site 391626003093 D-loop; other site 391626003094 H-loop/switch region; other site 391626003095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626003096 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391626003097 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626003098 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391626003099 Protein of unknown function (DUF917); Region: DUF917; pfam06032 391626003100 Protein of unknown function (DUF917); Region: DUF917; pfam06032 391626003101 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626003102 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391626003103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626003104 DNA binding site [nucleotide binding] 391626003105 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391626003106 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391626003107 putative ligand binding site [chemical binding]; other site 391626003108 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391626003109 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 391626003110 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 391626003111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626003112 motif II; other site 391626003113 Uncharacterized conserved protein [Function unknown]; Region: COG3586 391626003114 putative pectinesterase; Region: PLN02432; cl01911 391626003115 Hint domain; Region: Hint_2; pfam13403 391626003116 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391626003117 putative FMN binding site [chemical binding]; other site 391626003118 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391626003119 SPFH domain / Band 7 family; Region: Band_7; pfam01145 391626003120 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 391626003121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626003122 Transposase; Region: HTH_Tnp_1; pfam01527 391626003123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626003124 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626003125 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626003126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626003127 AAA domain; Region: AAA_23; pfam13476 391626003128 AAA domain; Region: AAA_27; pfam13514 391626003129 Walker A/P-loop; other site 391626003130 ATP binding site [chemical binding]; other site 391626003131 Rhomboid family; Region: Rhomboid; pfam01694 391626003132 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 391626003133 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 391626003134 DHH family; Region: DHH; pfam01368 391626003135 DHHA1 domain; Region: DHHA1; pfam02272 391626003136 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 391626003137 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 391626003138 putative active site [active] 391626003139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626003140 homoserine dehydrogenase; Provisional; Region: PRK06349 391626003141 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391626003142 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391626003143 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391626003144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626003145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626003146 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626003147 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 391626003148 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391626003149 TadE-like protein; Region: TadE; pfam07811 391626003150 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 391626003151 von Willebrand factor type A domain; Region: VWA_2; pfam13519 391626003152 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391626003153 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391626003154 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391626003155 NAD(P) binding site [chemical binding]; other site 391626003156 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391626003157 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626003158 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391626003159 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391626003160 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626003161 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391626003162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626003163 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391626003164 Walker A/P-loop; other site 391626003165 ATP binding site [chemical binding]; other site 391626003166 Q-loop/lid; other site 391626003167 ABC transporter signature motif; other site 391626003168 Walker B; other site 391626003169 D-loop; other site 391626003170 H-loop/switch region; other site 391626003171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626003172 dimer interface [polypeptide binding]; other site 391626003173 conserved gate region; other site 391626003174 putative PBP binding loops; other site 391626003175 ABC-ATPase subunit interface; other site 391626003176 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391626003177 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 391626003178 transcriptional regulator BetI; Validated; Region: PRK00767 391626003179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626003180 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391626003181 Sulfatase; Region: Sulfatase; cl17466 391626003182 choline-sulfatase; Region: chol_sulfatase; TIGR03417 391626003183 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 391626003184 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 391626003185 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391626003186 NAD(P) binding site [chemical binding]; other site 391626003187 catalytic residues [active] 391626003188 choline dehydrogenase; Validated; Region: PRK02106 391626003189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626003190 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626003191 Staphylococcal nuclease homologues; Region: SNc; smart00318 391626003192 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 391626003193 Catalytic site; other site 391626003194 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391626003195 putative hydrophobic ligand binding site [chemical binding]; other site 391626003196 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626003197 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626003198 non-specific DNA binding site [nucleotide binding]; other site 391626003199 salt bridge; other site 391626003200 sequence-specific DNA binding site [nucleotide binding]; other site 391626003201 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391626003202 Domain of unknown function (DUF955); Region: DUF955; pfam06114 391626003203 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391626003204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626003205 putative substrate translocation pore; other site 391626003206 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391626003207 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391626003208 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391626003209 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391626003210 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626003211 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391626003212 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391626003213 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391626003214 carboxyltransferase (CT) interaction site; other site 391626003215 biotinylation site [posttranslational modification]; other site 391626003216 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 391626003217 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 391626003218 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 391626003219 active site 391626003220 substrate binding site [chemical binding]; other site 391626003221 coenzyme B12 binding site [chemical binding]; other site 391626003222 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391626003223 B12 binding site [chemical binding]; other site 391626003224 cobalt ligand [ion binding]; other site 391626003225 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391626003226 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 391626003227 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626003228 Coenzyme A binding pocket [chemical binding]; other site 391626003229 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 391626003230 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 391626003231 putative metal binding site [ion binding]; other site 391626003232 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391626003233 HSP70 interaction site [polypeptide binding]; other site 391626003234 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626003235 putative catalytic site [active] 391626003236 putative metal binding site [ion binding]; other site 391626003237 putative phosphate binding site [ion binding]; other site 391626003238 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391626003239 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391626003240 polyphosphate kinase; Provisional; Region: PRK05443 391626003241 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 391626003242 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 391626003243 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 391626003244 putative domain interface [polypeptide binding]; other site 391626003245 putative active site [active] 391626003246 catalytic site [active] 391626003247 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391626003248 putative active site [active] 391626003249 catalytic site [active] 391626003250 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 391626003251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626003252 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391626003253 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391626003254 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391626003255 Fasciclin domain; Region: Fasciclin; pfam02469 391626003256 prolyl-tRNA synthetase; Provisional; Region: PRK12325 391626003257 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 391626003258 dimer interface [polypeptide binding]; other site 391626003259 motif 1; other site 391626003260 active site 391626003261 motif 2; other site 391626003262 motif 3; other site 391626003263 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 391626003264 anticodon binding site; other site 391626003265 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 391626003266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391626003267 FtsX-like permease family; Region: FtsX; pfam02687 391626003268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391626003269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391626003270 Walker A/P-loop; other site 391626003271 ATP binding site [chemical binding]; other site 391626003272 Q-loop/lid; other site 391626003273 ABC transporter signature motif; other site 391626003274 Walker B; other site 391626003275 D-loop; other site 391626003276 H-loop/switch region; other site 391626003277 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391626003278 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 391626003279 Cytochrome c; Region: Cytochrom_C; pfam00034 391626003280 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391626003281 MAPEG family; Region: MAPEG; cl09190 391626003282 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391626003283 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626003284 active site 391626003285 metal binding site [ion binding]; metal-binding site 391626003286 hexamer interface [polypeptide binding]; other site 391626003287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626003288 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391626003289 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 391626003290 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391626003291 putative NAD(P) binding site [chemical binding]; other site 391626003292 pyruvate carboxylase; Reviewed; Region: PRK12999 391626003293 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626003294 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626003295 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391626003296 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 391626003297 active site 391626003298 catalytic residues [active] 391626003299 metal binding site [ion binding]; metal-binding site 391626003300 homodimer binding site [polypeptide binding]; other site 391626003301 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391626003302 carboxyltransferase (CT) interaction site; other site 391626003303 biotinylation site [posttranslational modification]; other site 391626003304 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 391626003305 Part of AAA domain; Region: AAA_19; pfam13245 391626003306 Family description; Region: UvrD_C_2; pfam13538 391626003307 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391626003308 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626003309 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626003310 putative DNA binding site [nucleotide binding]; other site 391626003311 putative Zn2+ binding site [ion binding]; other site 391626003312 AsnC family; Region: AsnC_trans_reg; pfam01037 391626003313 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 391626003314 Domain of unknown function DUF59; Region: DUF59; pfam01883 391626003315 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 391626003316 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391626003317 Walker A motif; other site 391626003318 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391626003319 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626003320 cell division protein MraZ; Reviewed; Region: PRK00326 391626003321 MraZ protein; Region: MraZ; pfam02381 391626003322 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 391626003323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626003324 S-adenosylmethionine binding site [chemical binding]; other site 391626003325 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 391626003326 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391626003327 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391626003328 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391626003329 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391626003330 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391626003331 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391626003332 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391626003333 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 391626003334 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391626003335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391626003336 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391626003337 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 391626003338 Mg++ binding site [ion binding]; other site 391626003339 putative catalytic motif [active] 391626003340 putative substrate binding site [chemical binding]; other site 391626003341 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 391626003342 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626003343 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626003344 binding surface 391626003345 TPR motif; other site 391626003346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626003347 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626003348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626003349 binding surface 391626003350 TPR motif; other site 391626003351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626003352 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 391626003353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391626003354 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 391626003355 Predicted flavoproteins [General function prediction only]; Region: COG2081 391626003356 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626003357 cell division protein FtsW; Region: ftsW; TIGR02614 391626003358 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391626003359 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391626003360 active site 391626003361 homodimer interface [polypeptide binding]; other site 391626003362 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391626003363 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391626003364 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391626003365 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391626003366 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 391626003367 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 391626003368 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 391626003369 FAD binding domain; Region: FAD_binding_4; pfam01565 391626003370 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391626003371 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391626003372 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391626003373 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626003374 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391626003375 Cell division protein FtsQ; Region: FtsQ; pfam03799 391626003376 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 391626003377 Cell division protein FtsA; Region: FtsA; smart00842 391626003378 Cell division protein FtsA; Region: FtsA; pfam14450 391626003379 cell division protein FtsZ; Validated; Region: PRK09330 391626003380 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 391626003381 nucleotide binding site [chemical binding]; other site 391626003382 SulA interaction site; other site 391626003383 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 391626003384 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 391626003385 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 391626003386 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391626003387 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391626003388 Walker A/P-loop; other site 391626003389 ATP binding site [chemical binding]; other site 391626003390 Q-loop/lid; other site 391626003391 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391626003392 ABC transporter signature motif; other site 391626003393 Walker B; other site 391626003394 D-loop; other site 391626003395 H-loop/switch region; other site 391626003396 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391626003397 FAD binding domain; Region: FAD_binding_4; pfam01565 391626003398 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 391626003399 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 391626003400 Cl- selectivity filter; other site 391626003401 Cl- binding residues [ion binding]; other site 391626003402 pore gating glutamate residue; other site 391626003403 dimer interface [polypeptide binding]; other site 391626003404 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391626003405 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391626003406 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391626003407 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 391626003408 active site 391626003409 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 391626003410 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391626003411 metal ion-dependent adhesion site (MIDAS); other site 391626003412 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 391626003413 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 391626003414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626003415 RNA polymerase sigma factor; Provisional; Region: PRK12514 391626003416 RNA polymerase sigma factor; Provisional; Region: PRK12514 391626003417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 391626003418 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 391626003419 putative ADP-binding pocket [chemical binding]; other site 391626003420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391626003421 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391626003422 HSP70 interaction site [polypeptide binding]; other site 391626003423 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391626003424 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 391626003425 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391626003426 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391626003427 GatB domain; Region: GatB_Yqey; smart00845 391626003428 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626003429 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626003430 catalytic residue [active] 391626003431 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391626003432 Zn binding site [ion binding]; other site 391626003433 Domain of unknown function (DUF3458); Region: DUF3458; pfam11940 391626003434 malate synthase G; Provisional; Region: PRK02999 391626003435 active site 391626003436 Domain of unknown function (DUF336); Region: DUF336; cl01249 391626003437 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 391626003438 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391626003439 catalytic triad [active] 391626003440 Phospholipid methyltransferase; Region: PEMT; cl17370 391626003441 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391626003442 hydrophobic ligand binding site; other site 391626003443 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391626003444 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 391626003445 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 391626003446 ligand binding site [chemical binding]; other site 391626003447 homodimer interface [polypeptide binding]; other site 391626003448 NAD(P) binding site [chemical binding]; other site 391626003449 trimer interface B [polypeptide binding]; other site 391626003450 trimer interface A [polypeptide binding]; other site 391626003451 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391626003452 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 391626003453 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 391626003454 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626003455 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626003456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626003457 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626003458 Integrase core domain; Region: rve; pfam00665 391626003459 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391626003460 pseudouridine synthase; Region: TIGR00093 391626003461 active site 391626003462 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391626003463 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626003464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626003465 dimer interface [polypeptide binding]; other site 391626003466 conserved gate region; other site 391626003467 putative PBP binding loops; other site 391626003468 ABC-ATPase subunit interface; other site 391626003469 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626003471 dimer interface [polypeptide binding]; other site 391626003472 conserved gate region; other site 391626003473 putative PBP binding loops; other site 391626003474 ABC-ATPase subunit interface; other site 391626003475 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626003476 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 391626003477 peptide binding site [polypeptide binding]; other site 391626003478 dimer interface [polypeptide binding]; other site 391626003479 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 391626003480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626003481 Walker A/P-loop; other site 391626003482 ATP binding site [chemical binding]; other site 391626003483 Q-loop/lid; other site 391626003484 ABC transporter signature motif; other site 391626003485 Walker B; other site 391626003486 D-loop; other site 391626003487 H-loop/switch region; other site 391626003488 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391626003489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391626003490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626003491 Walker A/P-loop; other site 391626003492 ATP binding site [chemical binding]; other site 391626003493 Q-loop/lid; other site 391626003494 ABC transporter signature motif; other site 391626003495 Walker B; other site 391626003496 D-loop; other site 391626003497 H-loop/switch region; other site 391626003498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626003499 acetylornithine deacetylase; Provisional; Region: PRK07522 391626003500 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391626003501 metal binding site [ion binding]; metal-binding site 391626003502 putative dimer interface [polypeptide binding]; other site 391626003503 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391626003504 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391626003505 metal binding site [ion binding]; metal-binding site 391626003506 putative dimer interface [polypeptide binding]; other site 391626003507 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 391626003508 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626003509 FeS/SAM binding site; other site 391626003510 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391626003511 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391626003512 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 391626003513 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626003514 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 391626003515 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391626003516 oligomer interface [polypeptide binding]; other site 391626003517 active site residues [active] 391626003518 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391626003519 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391626003520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626003521 Walker A motif; other site 391626003522 ATP binding site [chemical binding]; other site 391626003523 Walker B motif; other site 391626003524 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391626003525 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 391626003526 homotrimer interaction site [polypeptide binding]; other site 391626003527 putative active site [active] 391626003528 NADH dehydrogenase; Validated; Region: PRK08183 391626003529 mce related protein; Region: MCE; pfam02470 391626003530 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 391626003531 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 391626003532 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391626003533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626003534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626003535 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391626003536 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 391626003537 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391626003538 carboxyltransferase (CT) interaction site; other site 391626003539 biotinylation site [posttranslational modification]; other site 391626003540 acetyl-CoA synthetase; Provisional; Region: PRK00174 391626003541 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391626003542 active site 391626003543 CoA binding site [chemical binding]; other site 391626003544 acyl-activating enzyme (AAE) consensus motif; other site 391626003545 AMP binding site [chemical binding]; other site 391626003546 acetate binding site [chemical binding]; other site 391626003547 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626003548 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626003549 Walker A/P-loop; other site 391626003550 ATP binding site [chemical binding]; other site 391626003551 Q-loop/lid; other site 391626003552 ABC transporter signature motif; other site 391626003553 Walker B; other site 391626003554 D-loop; other site 391626003555 H-loop/switch region; other site 391626003556 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626003557 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626003558 Walker A/P-loop; other site 391626003559 ATP binding site [chemical binding]; other site 391626003560 Q-loop/lid; other site 391626003561 ABC transporter signature motif; other site 391626003562 Walker B; other site 391626003563 D-loop; other site 391626003564 H-loop/switch region; other site 391626003565 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626003566 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626003567 TM-ABC transporter signature motif; other site 391626003568 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626003569 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626003570 TM-ABC transporter signature motif; other site 391626003571 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626003572 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391626003573 putative ligand binding site [chemical binding]; other site 391626003574 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626003575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626003576 non-specific DNA binding site [nucleotide binding]; other site 391626003577 salt bridge; other site 391626003578 sequence-specific DNA binding site [nucleotide binding]; other site 391626003579 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391626003580 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391626003581 Response regulator receiver domain; Region: Response_reg; pfam00072 391626003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626003583 active site 391626003584 phosphorylation site [posttranslational modification] 391626003585 intermolecular recognition site; other site 391626003586 dimerization interface [polypeptide binding]; other site 391626003587 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 391626003588 Na binding site [ion binding]; other site 391626003589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626003590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626003591 dimer interface [polypeptide binding]; other site 391626003592 phosphorylation site [posttranslational modification] 391626003593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626003594 ATP binding site [chemical binding]; other site 391626003595 Mg2+ binding site [ion binding]; other site 391626003596 G-X-G motif; other site 391626003597 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 391626003598 Putative phosphatase (DUF442); Region: DUF442; cl17385 391626003599 enoyl-CoA hydratase; Provisional; Region: PRK06688 391626003600 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626003601 substrate binding site [chemical binding]; other site 391626003602 oxyanion hole (OAH) forming residues; other site 391626003603 trimer interface [polypeptide binding]; other site 391626003604 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 391626003605 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 391626003606 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391626003607 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391626003608 active site 391626003609 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 391626003610 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 391626003611 putative active site [active] 391626003612 putative NTP binding site [chemical binding]; other site 391626003613 putative nucleic acid binding site [nucleotide binding]; other site 391626003614 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626003615 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626003616 active site 391626003617 DNA binding site [nucleotide binding] 391626003618 Int/Topo IB signature motif; other site 391626003619 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626003620 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626003621 active site 391626003622 catalytic residues [active] 391626003623 DNA binding site [nucleotide binding] 391626003624 Int/Topo IB signature motif; other site 391626003625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626003626 Integrase core domain; Region: rve; pfam00665 391626003627 transposase/IS protein; Provisional; Region: PRK09183 391626003628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626003629 Walker A motif; other site 391626003630 ATP binding site [chemical binding]; other site 391626003631 Walker B motif; other site 391626003632 arginine finger; other site 391626003633 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391626003634 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 391626003635 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 391626003636 HNH endonuclease; Region: HNH_3; pfam13392 391626003637 H-type lectin domain; Region: H_lectin; pfam09458 391626003638 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626003639 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626003640 MULE transposase domain; Region: MULE; pfam10551 391626003641 Transposase domain (DUF772); Region: DUF772; pfam05598 391626003642 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 391626003643 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391626003644 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391626003645 HTH-like domain; Region: HTH_21; pfam13276 391626003646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626003647 Integrase core domain; Region: rve; pfam00665 391626003648 Integrase core domain; Region: rve_3; cl15866 391626003649 Transposase; Region: HTH_Tnp_1; cl17663 391626003650 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 391626003651 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 391626003652 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 391626003653 DXD motif; other site 391626003654 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391626003655 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 391626003656 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391626003657 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 391626003658 ATP binding site [chemical binding]; other site 391626003659 Mg2+ binding site [ion binding]; other site 391626003660 G-X-G motif; other site 391626003661 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391626003662 anti sigma factor interaction site; other site 391626003663 regulatory phosphorylation site [posttranslational modification]; other site 391626003664 Response regulator receiver domain; Region: Response_reg; pfam00072 391626003665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626003666 active site 391626003667 phosphorylation site [posttranslational modification] 391626003668 intermolecular recognition site; other site 391626003669 dimerization interface [polypeptide binding]; other site 391626003670 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391626003671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391626003672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626003673 active site 391626003674 phosphorylation site [posttranslational modification] 391626003675 intermolecular recognition site; other site 391626003676 dimerization interface [polypeptide binding]; other site 391626003677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626003678 DNA binding residues [nucleotide binding] 391626003679 dimerization interface [polypeptide binding]; other site 391626003680 Transposase domain (DUF772); Region: DUF772; pfam05598 391626003681 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 391626003682 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391626003683 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391626003684 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391626003685 active site 391626003686 tetramer interface; other site 391626003687 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391626003688 metal coordination site [ion binding]; other site 391626003689 PAS domain S-box; Region: sensory_box; TIGR00229 391626003690 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626003691 putative active site [active] 391626003692 heme pocket [chemical binding]; other site 391626003693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626003694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626003695 dimer interface [polypeptide binding]; other site 391626003696 phosphorylation site [posttranslational modification] 391626003697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626003698 ATP binding site [chemical binding]; other site 391626003699 Mg2+ binding site [ion binding]; other site 391626003700 G-X-G motif; other site 391626003701 Response regulator receiver domain; Region: Response_reg; pfam00072 391626003702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626003703 active site 391626003704 phosphorylation site [posttranslational modification] 391626003705 intermolecular recognition site; other site 391626003706 dimerization interface [polypeptide binding]; other site 391626003707 Hpt domain; Region: Hpt; pfam01627 391626003708 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626003709 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626003710 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391626003711 Hint domain; Region: Hint_2; pfam13403 391626003712 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626003713 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626003714 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391626003715 MarR family; Region: MarR_2; cl17246 391626003716 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 391626003717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626003718 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391626003719 NAD(P) binding site [chemical binding]; other site 391626003720 active site 391626003721 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 391626003722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391626003723 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626003724 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626003725 active site 391626003726 catalytic residues [active] 391626003727 DNA binding site [nucleotide binding] 391626003728 Int/Topo IB signature motif; other site 391626003729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626003730 Transposase; Region: HTH_Tnp_1; pfam01527 391626003731 HTH-like domain; Region: HTH_21; pfam13276 391626003732 Integrase core domain; Region: rve; pfam00665 391626003733 Integrase core domain; Region: rve_3; pfam13683 391626003734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626003735 DNA-binding site [nucleotide binding]; DNA binding site 391626003736 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391626003737 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626003738 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626003739 homodimer interface [polypeptide binding]; other site 391626003740 catalytic residue [active] 391626003741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626003742 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391626003743 phosphate binding site [ion binding]; other site 391626003744 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626003745 dimerization interface [polypeptide binding]; other site 391626003746 putative DNA binding site [nucleotide binding]; other site 391626003747 putative Zn2+ binding site [ion binding]; other site 391626003748 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391626003749 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391626003750 heme binding site [chemical binding]; other site 391626003751 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391626003752 heme binding site [chemical binding]; other site 391626003753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626003754 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 391626003755 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 391626003756 dimerization interface [polypeptide binding]; other site 391626003757 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 391626003758 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391626003759 putative acyl-acceptor binding pocket; other site 391626003760 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391626003761 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 391626003762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626003763 catalytic residue [active] 391626003764 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626003765 EamA-like transporter family; Region: EamA; pfam00892 391626003766 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 391626003767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626003768 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626003769 Winged helix-turn helix; Region: HTH_29; pfam13551 391626003770 Homeodomain-like domain; Region: HTH_32; pfam13565 391626003771 Integrase core domain; Region: rve; pfam00665 391626003772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626003773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626003774 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626003775 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626003776 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626003777 ABC transporter transmembrane region; Region: ABC_membrane_3; pfam13748 391626003778 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391626003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626003780 S-adenosylmethionine binding site [chemical binding]; other site 391626003781 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391626003782 Sel1-like repeats; Region: SEL1; smart00671 391626003783 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626003784 Winged helix-turn helix; Region: HTH_29; pfam13551 391626003785 Homeodomain-like domain; Region: HTH_32; pfam13565 391626003786 Integrase core domain; Region: rve; pfam00665 391626003787 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391626003788 metal binding site 2 [ion binding]; metal-binding site 391626003789 putative DNA binding helix; other site 391626003790 metal binding site 1 [ion binding]; metal-binding site 391626003791 structural Zn2+ binding site [ion binding]; other site 391626003792 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 391626003793 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 391626003794 metal binding site [ion binding]; metal-binding site 391626003795 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 391626003796 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391626003797 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391626003798 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391626003799 ABC-ATPase subunit interface; other site 391626003800 dimer interface [polypeptide binding]; other site 391626003801 putative PBP binding regions; other site 391626003802 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391626003803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391626003804 ABC-ATPase subunit interface; other site 391626003805 dimer interface [polypeptide binding]; other site 391626003806 putative PBP binding regions; other site 391626003807 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391626003808 metal binding site 2 [ion binding]; metal-binding site 391626003809 putative DNA binding helix; other site 391626003810 metal binding site 1 [ion binding]; metal-binding site 391626003811 dimer interface [polypeptide binding]; other site 391626003812 manganese transport regulator MntR; Provisional; Region: PRK11050 391626003813 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 391626003814 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 391626003815 Protein of unknown function (DUF2753); Region: DUF2753; pfam10952 391626003816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 391626003817 Anti-sigma-K factor rskA; Region: RskA; pfam10099 391626003818 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391626003819 Fasciclin domain; Region: Fasciclin; pfam02469 391626003820 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 391626003821 SelR domain; Region: SelR; pfam01641 391626003822 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626003823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626003824 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391626003825 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 391626003826 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391626003827 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 391626003828 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 391626003829 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 391626003830 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 391626003831 metal binding site [ion binding]; metal-binding site 391626003832 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 391626003833 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391626003834 substrate binding site [chemical binding]; other site 391626003835 glutamase interaction surface [polypeptide binding]; other site 391626003836 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391626003837 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391626003838 catalytic residues [active] 391626003839 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 391626003840 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391626003841 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391626003842 putative active site [active] 391626003843 oxyanion strand; other site 391626003844 catalytic triad [active] 391626003845 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391626003846 putative active site pocket [active] 391626003847 4-fold oligomerization interface [polypeptide binding]; other site 391626003848 metal binding residues [ion binding]; metal-binding site 391626003849 3-fold/trimer interface [polypeptide binding]; other site 391626003850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626003851 Coenzyme A binding pocket [chemical binding]; other site 391626003852 Transposase domain (DUF772); Region: DUF772; pfam05598 391626003853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391626003854 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391626003855 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 391626003856 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 391626003857 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391626003858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391626003859 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391626003860 active site 391626003861 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626003862 classical (c) SDRs; Region: SDR_c; cd05233 391626003863 NAD(P) binding site [chemical binding]; other site 391626003864 active site 391626003865 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626003866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626003867 non-specific DNA binding site [nucleotide binding]; other site 391626003868 salt bridge; other site 391626003869 sequence-specific DNA binding site [nucleotide binding]; other site 391626003870 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 391626003871 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391626003872 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391626003873 putative di-iron ligands [ion binding]; other site 391626003874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391626003875 nudix motif; other site 391626003876 Protein of unknown function (DUF983); Region: DUF983; cl02211 391626003877 EF-hand domain pair; Region: EF_hand_5; pfam13499 391626003878 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 391626003879 Ca2+ binding site [ion binding]; other site 391626003880 RNA polymerase sigma factor; Provisional; Region: PRK12524 391626003881 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626003882 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391626003883 DNA binding residues [nucleotide binding] 391626003884 Heavy-metal resistance; Region: Metal_resist; pfam13801 391626003885 response regulator PleD; Reviewed; Region: pleD; PRK09581 391626003886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626003887 active site 391626003888 phosphorylation site [posttranslational modification] 391626003889 intermolecular recognition site; other site 391626003890 dimerization interface [polypeptide binding]; other site 391626003891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626003892 metal binding site [ion binding]; metal-binding site 391626003893 active site 391626003894 I-site; other site 391626003895 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 391626003896 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391626003897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626003898 motif II; other site 391626003899 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391626003900 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 391626003901 putative active site [active] 391626003902 dimerization interface [polypeptide binding]; other site 391626003903 putative tRNAtyr binding site [nucleotide binding]; other site 391626003904 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626003905 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 391626003906 putative substrate binding site [chemical binding]; other site 391626003907 putative ATP binding site [chemical binding]; other site 391626003908 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 391626003909 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 391626003910 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391626003911 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 391626003912 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 391626003913 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391626003914 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391626003915 RNA binding surface [nucleotide binding]; other site 391626003916 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391626003917 active site 391626003918 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391626003919 nucleoside/Zn binding site; other site 391626003920 dimer interface [polypeptide binding]; other site 391626003921 catalytic motif [active] 391626003922 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 391626003923 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391626003924 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 391626003925 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 391626003926 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391626003927 amidase catalytic site [active] 391626003928 Zn binding residues [ion binding]; other site 391626003929 substrate binding site [chemical binding]; other site 391626003930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391626003931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391626003932 active site 391626003933 catalytic tetrad [active] 391626003934 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 391626003935 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 391626003936 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 391626003937 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 391626003938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626003939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626003940 dimerization interface [polypeptide binding]; other site 391626003941 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391626003942 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391626003943 NAD(P) binding site [chemical binding]; other site 391626003944 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626003945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626003946 non-specific DNA binding site [nucleotide binding]; other site 391626003947 salt bridge; other site 391626003948 sequence-specific DNA binding site [nucleotide binding]; other site 391626003949 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391626003950 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391626003951 active site 391626003952 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 391626003953 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 391626003954 active site 391626003955 putative substrate binding pocket [chemical binding]; other site 391626003956 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 391626003957 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391626003958 guanine deaminase; Provisional; Region: PRK09228 391626003959 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 391626003960 active site 391626003961 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 391626003962 MgtE intracellular N domain; Region: MgtE_N; smart00924 391626003963 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 391626003964 Divalent cation transporter; Region: MgtE; cl00786 391626003965 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 391626003966 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 391626003967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391626003968 putative active site [active] 391626003969 metal binding site [ion binding]; metal-binding site 391626003970 homodimer binding site [polypeptide binding]; other site 391626003971 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626003972 EamA-like transporter family; Region: EamA; pfam00892 391626003973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391626003974 transmembrane helices; other site 391626003975 TrkA-C domain; Region: TrkA_C; pfam02080 391626003976 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 391626003977 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391626003978 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391626003979 catalytic triad [active] 391626003980 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391626003981 transmembrane helices; other site 391626003982 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391626003983 TrkA-C domain; Region: TrkA_C; pfam02080 391626003984 TrkA-C domain; Region: TrkA_C; pfam02080 391626003985 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 391626003986 hypothetical protein; Validated; Region: PRK00110 391626003987 Lysine efflux permease [General function prediction only]; Region: COG1279 391626003988 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626003989 DNA primase; Validated; Region: dnaG; PRK05667 391626003990 CHC2 zinc finger; Region: zf-CHC2; cl17510 391626003991 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391626003992 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391626003993 active site 391626003994 metal binding site [ion binding]; metal-binding site 391626003995 interdomain interaction site; other site 391626003996 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391626003997 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 391626003998 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 391626003999 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391626004000 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 391626004001 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626004002 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391626004003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626004004 DNA binding residues [nucleotide binding] 391626004005 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 391626004006 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391626004007 ATP cone domain; Region: ATP-cone; pfam03477 391626004008 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 391626004009 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391626004010 catalytic motif [active] 391626004011 Zn binding site [ion binding]; other site 391626004012 RibD C-terminal domain; Region: RibD_C; cl17279 391626004013 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 391626004014 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 391626004015 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391626004016 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 391626004017 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 391626004018 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 391626004019 Lumazine binding domain; Region: Lum_binding; pfam00677 391626004020 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 391626004021 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 391626004022 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 391626004023 dimerization interface [polypeptide binding]; other site 391626004024 active site 391626004025 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 391626004026 homopentamer interface [polypeptide binding]; other site 391626004027 active site 391626004028 transcription antitermination factor NusB; Region: nusB; TIGR01951 391626004029 putative RNA binding site [nucleotide binding]; other site 391626004030 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391626004031 putative hydrophobic ligand binding site [chemical binding]; other site 391626004032 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 391626004033 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626004034 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391626004035 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391626004036 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391626004037 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391626004038 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 391626004039 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 391626004040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391626004041 RNA binding surface [nucleotide binding]; other site 391626004042 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391626004043 active site 391626004044 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 391626004045 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391626004046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626004047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626004048 DNA binding residues [nucleotide binding] 391626004049 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626004050 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626004051 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626004052 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 391626004053 hypothetical protein; Provisional; Region: PRK11019 391626004054 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 391626004055 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 391626004056 active site 391626004057 Zn binding site [ion binding]; other site 391626004058 ATP-dependent DNA ligase; Validated; Region: PRK09247 391626004059 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 391626004060 active site 391626004061 DNA binding site [nucleotide binding] 391626004062 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 391626004063 DNA binding site [nucleotide binding] 391626004064 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 391626004065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391626004066 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 391626004067 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 391626004068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391626004069 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 391626004070 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391626004071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626004072 binding surface 391626004073 TPR repeat; Region: TPR_11; pfam13414 391626004074 TPR motif; other site 391626004075 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391626004076 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391626004077 ATP binding site [chemical binding]; other site 391626004078 putative Mg++ binding site [ion binding]; other site 391626004079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626004080 nucleotide binding region [chemical binding]; other site 391626004081 ATP-binding site [chemical binding]; other site 391626004082 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391626004083 RNA binding surface [nucleotide binding]; other site 391626004084 Ferredoxin [Energy production and conversion]; Region: COG1146 391626004085 4Fe-4S binding domain; Region: Fer4; pfam00037 391626004086 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391626004087 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 391626004088 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391626004089 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391626004090 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 391626004091 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391626004092 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391626004093 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 391626004094 generic binding surface II; other site 391626004095 generic binding surface I; other site 391626004096 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 391626004097 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 391626004098 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391626004099 P loop; other site 391626004100 GTP binding site [chemical binding]; other site 391626004101 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391626004102 EamA-like transporter family; Region: EamA; pfam00892 391626004103 Intracellular septation protein A; Region: IspA; pfam04279 391626004104 PilZ domain; Region: PilZ; pfam07238 391626004105 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 391626004106 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391626004107 C-terminal domain interface [polypeptide binding]; other site 391626004108 GSH binding site (G-site) [chemical binding]; other site 391626004109 dimer interface [polypeptide binding]; other site 391626004110 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 391626004111 N-terminal domain interface [polypeptide binding]; other site 391626004112 putative dimer interface [polypeptide binding]; other site 391626004113 active site 391626004114 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 391626004115 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626004116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626004117 catalytic residue [active] 391626004118 putative GTP cyclohydrolase; Provisional; Region: PRK13674 391626004119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626004120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626004121 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391626004122 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626004123 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391626004124 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391626004125 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626004126 hypothetical protein; Provisional; Region: PRK07524 391626004127 PYR/PP interface [polypeptide binding]; other site 391626004128 dimer interface [polypeptide binding]; other site 391626004129 TPP binding site [chemical binding]; other site 391626004130 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626004131 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391626004132 TPP-binding site [chemical binding]; other site 391626004133 His-Xaa-Ser repeat protein HxsA; Region: His_Ser_Rich; TIGR03979 391626004134 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626004135 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391626004136 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391626004137 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 391626004138 dimer interface [polypeptide binding]; other site 391626004139 motif 1; other site 391626004140 active site 391626004141 motif 2; other site 391626004142 motif 3; other site 391626004143 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 391626004144 pyruvate phosphate dikinase; Provisional; Region: PRK09279 391626004145 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391626004146 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391626004147 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 391626004148 Dihydroneopterin aldolase; Region: FolB; smart00905 391626004149 active site 391626004150 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 391626004151 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391626004152 dihydropteroate synthase; Region: DHPS; TIGR01496 391626004153 substrate binding pocket [chemical binding]; other site 391626004154 dimer interface [polypeptide binding]; other site 391626004155 inhibitor binding site; inhibition site 391626004156 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 391626004157 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 391626004158 active site 391626004159 substrate binding site [chemical binding]; other site 391626004160 metal binding site [ion binding]; metal-binding site 391626004161 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391626004162 EamA-like transporter family; Region: EamA; pfam00892 391626004163 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 391626004164 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 391626004165 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391626004166 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 391626004167 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391626004168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 391626004169 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626004170 AsnC family; Region: AsnC_trans_reg; pfam01037 391626004171 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626004172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626004173 putative DNA binding site [nucleotide binding]; other site 391626004174 putative Zn2+ binding site [ion binding]; other site 391626004175 AsnC family; Region: AsnC_trans_reg; pfam01037 391626004176 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391626004177 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626004178 catalytic residue [active] 391626004179 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 391626004180 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 391626004181 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 391626004182 putative efflux protein, MATE family; Region: matE; TIGR00797 391626004183 cation binding site [ion binding]; other site 391626004184 aspartate aminotransferase; Provisional; Region: PRK05764 391626004185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626004186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626004187 homodimer interface [polypeptide binding]; other site 391626004188 catalytic residue [active] 391626004189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626004190 non-specific DNA binding site [nucleotide binding]; other site 391626004191 salt bridge; other site 391626004192 sequence-specific DNA binding site [nucleotide binding]; other site 391626004193 Uncharacterized conserved protein [Function unknown]; Region: COG2938 391626004194 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391626004195 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626004196 active site 391626004197 DNA binding site [nucleotide binding] 391626004198 Int/Topo IB signature motif; other site 391626004199 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391626004200 VRR-NUC domain; Region: VRR_NUC; cl17748 391626004201 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391626004202 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 391626004203 putative active site [active] 391626004204 Zn binding site [ion binding]; other site 391626004205 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391626004206 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391626004207 catalytic residues [active] 391626004208 catalytic nucleophile [active] 391626004209 Presynaptic Site I dimer interface [polypeptide binding]; other site 391626004210 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391626004211 Synaptic Flat tetramer interface [polypeptide binding]; other site 391626004212 Synaptic Site I dimer interface [polypeptide binding]; other site 391626004213 DNA binding site [nucleotide binding] 391626004214 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 391626004215 DNA-binding interface [nucleotide binding]; DNA binding site 391626004216 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 391626004217 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391626004218 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391626004219 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391626004220 dimer interface [polypeptide binding]; other site 391626004221 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626004222 active site 391626004223 metal binding site [ion binding]; metal-binding site 391626004224 glutathione binding site [chemical binding]; other site 391626004225 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 391626004226 FRG domain; Region: FRG; pfam08867 391626004227 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391626004228 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391626004229 Predicted membrane protein [Function unknown]; Region: COG2259 391626004230 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 391626004231 hypothetical protein; Provisional; Region: PRK05409 391626004232 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 391626004233 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 391626004234 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391626004235 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391626004236 active site 391626004237 dimer interface [polypeptide binding]; other site 391626004238 motif 1; other site 391626004239 motif 2; other site 391626004240 motif 3; other site 391626004241 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 391626004242 anticodon binding site; other site 391626004243 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626004244 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391626004245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626004246 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 391626004247 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 391626004248 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 391626004249 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 391626004250 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 391626004251 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 391626004252 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391626004253 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626004254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626004255 catalytic residue [active] 391626004256 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391626004257 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391626004258 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391626004259 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 391626004260 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391626004261 catalytic triad [active] 391626004262 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391626004263 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391626004264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004265 dimer interface [polypeptide binding]; other site 391626004266 conserved gate region; other site 391626004267 putative PBP binding loops; other site 391626004268 ABC-ATPase subunit interface; other site 391626004269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004270 ABC-ATPase subunit interface; other site 391626004271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626004272 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626004273 substrate binding pocket [chemical binding]; other site 391626004274 membrane-bound complex binding site; other site 391626004275 hinge residues; other site 391626004276 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626004277 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626004278 substrate binding pocket [chemical binding]; other site 391626004279 membrane-bound complex binding site; other site 391626004280 hinge residues; other site 391626004281 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391626004282 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391626004283 Walker A/P-loop; other site 391626004284 ATP binding site [chemical binding]; other site 391626004285 Q-loop/lid; other site 391626004286 ABC transporter signature motif; other site 391626004287 Walker B; other site 391626004288 D-loop; other site 391626004289 H-loop/switch region; other site 391626004290 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 391626004291 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391626004292 putative metal binding site [ion binding]; other site 391626004293 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391626004294 putative metal binding site [ion binding]; other site 391626004295 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 391626004296 CTP synthetase; Validated; Region: pyrG; PRK05380 391626004297 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 391626004298 active site 391626004299 UTP binding site [chemical binding]; other site 391626004300 Catalytic site [active] 391626004301 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391626004302 active site 391626004303 putative oxyanion hole; other site 391626004304 catalytic triad [active] 391626004305 protein translocase, SecG subunit; Region: secG; TIGR00810 391626004306 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391626004307 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391626004308 GDP-binding site [chemical binding]; other site 391626004309 ACT binding site; other site 391626004310 IMP binding site; other site 391626004311 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 391626004312 Thiamine pyrophosphokinase; Region: TPK; cd07995 391626004313 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 391626004314 active site 391626004315 dimerization interface [polypeptide binding]; other site 391626004316 thiamine binding site [chemical binding]; other site 391626004317 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626004318 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391626004319 EamA-like transporter family; Region: EamA; pfam00892 391626004320 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 391626004321 substrate binding pocket [chemical binding]; other site 391626004322 active site 391626004323 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391626004324 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391626004325 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 391626004326 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 391626004327 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391626004328 active site 391626004329 dimer interface [polypeptide binding]; other site 391626004330 glutathione reductase; Validated; Region: PRK06116 391626004331 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626004332 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626004333 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626004334 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 391626004335 HflK protein; Region: hflK; TIGR01933 391626004336 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 391626004337 HflC protein; Region: hflC; TIGR01932 391626004338 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391626004339 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391626004340 ligand binding site [chemical binding]; other site 391626004341 flexible hinge region; other site 391626004342 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391626004343 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391626004344 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391626004345 protein binding site [polypeptide binding]; other site 391626004346 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391626004347 protein binding site [polypeptide binding]; other site 391626004348 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626004349 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391626004350 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626004351 catalytic loop [active] 391626004352 iron binding site [ion binding]; other site 391626004353 Family description; Region: VCBS; pfam13517 391626004354 cobalamin synthase; Reviewed; Region: cobS; PRK00235 391626004355 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 391626004356 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 391626004357 putative dimer interface [polypeptide binding]; other site 391626004358 active site pocket [active] 391626004359 putative cataytic base [active] 391626004360 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 391626004361 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391626004362 TrkA-N domain; Region: TrkA_N; pfam02254 391626004363 large tegument protein UL36; Provisional; Region: PHA03247 391626004364 Uncharacterized conserved protein [Function unknown]; Region: COG2968 391626004365 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 391626004366 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 391626004367 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391626004368 homodimer interface [polypeptide binding]; other site 391626004369 substrate-cofactor binding pocket; other site 391626004370 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626004371 catalytic residue [active] 391626004372 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391626004373 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626004374 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626004375 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391626004376 Transposase; Region: HTH_Tnp_1; cl17663 391626004377 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626004378 Transposase domain (DUF772); Region: DUF772; pfam05598 391626004379 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391626004380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391626004381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391626004382 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391626004383 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626004384 ligand binding site [chemical binding]; other site 391626004385 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626004386 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626004387 TM-ABC transporter signature motif; other site 391626004388 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626004389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626004390 Walker A/P-loop; other site 391626004391 ATP binding site [chemical binding]; other site 391626004392 Q-loop/lid; other site 391626004393 ABC transporter signature motif; other site 391626004394 Walker B; other site 391626004395 D-loop; other site 391626004396 H-loop/switch region; other site 391626004397 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391626004398 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391626004399 NAD(P) binding site [chemical binding]; other site 391626004400 catalytic residues [active] 391626004401 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391626004402 NAD(P) binding site [chemical binding]; other site 391626004403 catalytic residues [active] 391626004404 choline dehydrogenase; Validated; Region: PRK02106 391626004405 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626004406 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391626004407 Permease; Region: Permease; pfam02405 391626004408 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626004409 acyl-activating enzyme (AAE) consensus motif; other site 391626004410 AMP binding site [chemical binding]; other site 391626004411 active site 391626004412 CoA binding site [chemical binding]; other site 391626004413 Predicted deacylase [General function prediction only]; Region: COG3608 391626004414 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 391626004415 putative active site [active] 391626004416 Zn binding site [ion binding]; other site 391626004417 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 391626004418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626004419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626004420 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391626004421 dimerization interface [polypeptide binding]; other site 391626004422 NADH dehydrogenase subunit E; Validated; Region: PRK07539 391626004423 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 391626004424 putative dimer interface [polypeptide binding]; other site 391626004425 [2Fe-2S] cluster binding site [ion binding]; other site 391626004426 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 391626004427 putative dimer interface [polypeptide binding]; other site 391626004428 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 391626004429 SLBB domain; Region: SLBB; pfam10531 391626004430 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391626004431 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391626004432 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626004433 catalytic loop [active] 391626004434 iron binding site [ion binding]; other site 391626004435 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391626004436 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 391626004437 [4Fe-4S] binding site [ion binding]; other site 391626004438 molybdopterin cofactor binding site; other site 391626004439 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 391626004440 molybdopterin cofactor binding site; other site 391626004441 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 391626004442 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 391626004443 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 391626004444 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 391626004445 putative active site [active] 391626004446 putative PHP Thumb interface [polypeptide binding]; other site 391626004447 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391626004448 generic binding surface I; other site 391626004449 generic binding surface II; other site 391626004450 DNA Polymerase Y-family; Region: PolY_like; cd03468 391626004451 active site 391626004452 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 391626004453 DNA binding site [nucleotide binding] 391626004454 Uncharacterized conserved protein [Function unknown]; Region: COG4544 391626004455 hypothetical protein; Validated; Region: PRK08223 391626004456 ThiF family; Region: ThiF; pfam00899 391626004457 ATP binding site [chemical binding]; other site 391626004458 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 391626004459 dimer interface [polypeptide binding]; other site 391626004460 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391626004461 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391626004462 Sel1-like repeats; Region: SEL1; smart00671 391626004463 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626004464 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626004465 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626004466 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626004467 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391626004468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391626004469 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391626004470 active site 391626004471 catalytic tetrad [active] 391626004472 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 391626004473 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 391626004474 active site 391626004475 dimer interface [polypeptide binding]; other site 391626004476 non-prolyl cis peptide bond; other site 391626004477 insertion regions; other site 391626004478 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391626004479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626004480 DNA-binding site [nucleotide binding]; DNA binding site 391626004481 UTRA domain; Region: UTRA; pfam07702 391626004482 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626004483 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626004484 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626004485 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391626004486 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391626004487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626004488 Mg2+ binding site [ion binding]; other site 391626004489 G-X-G motif; other site 391626004490 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391626004491 anchoring element; other site 391626004492 dimer interface [polypeptide binding]; other site 391626004493 ATP binding site [chemical binding]; other site 391626004494 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391626004495 active site 391626004496 metal binding site [ion binding]; metal-binding site 391626004497 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391626004498 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626004499 extended (e) SDRs; Region: SDR_e; cd08946 391626004500 NAD(P) binding site [chemical binding]; other site 391626004501 active site 391626004502 substrate binding site [chemical binding]; other site 391626004503 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391626004504 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 391626004505 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 391626004506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391626004507 motif II; other site 391626004508 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626004509 DNA-binding site [nucleotide binding]; DNA binding site 391626004510 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391626004511 FCD domain; Region: FCD; pfam07729 391626004512 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 391626004513 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 391626004514 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 391626004515 DXD motif; other site 391626004516 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391626004517 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 391626004518 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391626004519 catalytic site [active] 391626004520 subunit interface [polypeptide binding]; other site 391626004521 Yqey-like protein; Region: YqeY; pfam09424 391626004522 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626004523 EamA-like transporter family; Region: EamA; pfam00892 391626004524 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 391626004525 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 391626004526 Subunit I/III interface [polypeptide binding]; other site 391626004527 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391626004528 D-pathway; other site 391626004529 Subunit I/VIIc interface [polypeptide binding]; other site 391626004530 Subunit I/IV interface [polypeptide binding]; other site 391626004531 Subunit I/II interface [polypeptide binding]; other site 391626004532 Low-spin heme (heme a) binding site [chemical binding]; other site 391626004533 Subunit I/VIIa interface [polypeptide binding]; other site 391626004534 Subunit I/VIa interface [polypeptide binding]; other site 391626004535 Dimer interface; other site 391626004536 Putative water exit pathway; other site 391626004537 Binuclear center (heme a3/CuB) [ion binding]; other site 391626004538 K-pathway; other site 391626004539 Subunit I/Vb interface [polypeptide binding]; other site 391626004540 Putative proton exit pathway; other site 391626004541 Subunit I/VIb interface; other site 391626004542 Subunit I/VIc interface [polypeptide binding]; other site 391626004543 Electron transfer pathway; other site 391626004544 Subunit I/VIIIb interface [polypeptide binding]; other site 391626004545 Subunit I/VIIb interface [polypeptide binding]; other site 391626004546 lipoate-protein ligase B; Provisional; Region: PRK14341 391626004547 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 391626004548 LytTr DNA-binding domain; Region: LytTR; smart00850 391626004549 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 391626004550 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 391626004551 Integrase core domain; Region: rve_3; pfam13683 391626004552 HTH-like domain; Region: HTH_21; pfam13276 391626004553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626004554 Integrase core domain; Region: rve; pfam00665 391626004555 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 391626004556 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 391626004557 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 391626004558 potential catalytic triad [active] 391626004559 conserved cys residue [active] 391626004560 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 391626004561 Prostaglandin dehydrogenases; Region: PGDH; cd05288 391626004562 NAD(P) binding site [chemical binding]; other site 391626004563 substrate binding site [chemical binding]; other site 391626004564 dimer interface [polypeptide binding]; other site 391626004565 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 391626004566 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 391626004567 dimer interface [polypeptide binding]; other site 391626004568 active site 391626004569 metal binding site [ion binding]; metal-binding site 391626004570 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 391626004571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626004572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626004573 AAA domain; Region: AAA_25; pfam13481 391626004574 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626004575 Walker A motif; other site 391626004576 ATP binding site [chemical binding]; other site 391626004577 Walker B motif; other site 391626004578 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 391626004579 heat shock protein 90; Provisional; Region: PRK05218 391626004580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626004581 ATP binding site [chemical binding]; other site 391626004582 Mg2+ binding site [ion binding]; other site 391626004583 G-X-G motif; other site 391626004584 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 391626004585 nudix motif; other site 391626004586 Family description; Region: UvrD_C_2; pfam13538 391626004587 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391626004588 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391626004589 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 391626004590 N- and C-terminal domain interface [polypeptide binding]; other site 391626004591 putative active site [active] 391626004592 putative MgATP binding site [chemical binding]; other site 391626004593 putative catalytic site [active] 391626004594 metal binding site [ion binding]; metal-binding site 391626004595 putative carbohydrate binding site [chemical binding]; other site 391626004596 Domain of unknown function (DUF718); Region: DUF718; pfam05336 391626004597 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626004598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626004599 TM-ABC transporter signature motif; other site 391626004600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626004601 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626004602 TM-ABC transporter signature motif; other site 391626004603 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626004604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626004605 Walker A/P-loop; other site 391626004606 ATP binding site [chemical binding]; other site 391626004607 Q-loop/lid; other site 391626004608 ABC transporter signature motif; other site 391626004609 Walker B; other site 391626004610 D-loop; other site 391626004611 H-loop/switch region; other site 391626004612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626004613 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391626004614 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 391626004615 ligand binding site [chemical binding]; other site 391626004616 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391626004617 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391626004618 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391626004619 short chain dehydrogenase; Validated; Region: PRK08324 391626004620 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 391626004621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626004622 NAD(P) binding site [chemical binding]; other site 391626004623 active site 391626004624 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 391626004625 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 391626004626 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391626004627 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626004628 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391626004629 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391626004630 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 391626004631 catalytic residues [active] 391626004632 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 391626004633 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 391626004634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626004635 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 391626004636 active site 391626004637 Int/Topo IB signature motif; other site 391626004638 DNA binding site [nucleotide binding] 391626004639 VRR-NUC domain; Region: VRR_NUC; pfam08774 391626004640 Helix-turn-helix domain; Region: HTH_36; pfam13730 391626004641 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 391626004642 mercuric reductase; Region: MerA; TIGR02053 391626004643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626004644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626004645 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626004646 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 391626004647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391626004648 metal-binding site [ion binding] 391626004649 MerT mercuric transport protein; Region: MerT; cl03578 391626004650 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391626004651 DNA binding residues [nucleotide binding] 391626004652 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 391626004653 dimer interface [polypeptide binding]; other site 391626004654 putative metal binding site [ion binding]; other site 391626004655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626004656 EamA-like transporter family; Region: EamA; pfam00892 391626004657 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626004658 AAA domain; Region: AAA_21; pfam13304 391626004659 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391626004660 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391626004661 ParB-like nuclease domain; Region: ParBc; pfam02195 391626004662 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391626004663 DNA methylase; Region: N6_N4_Mtase; pfam01555 391626004664 HEPN domain; Region: HEPN; cl00824 391626004665 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391626004666 LrgB-like family; Region: LrgB; pfam04172 391626004667 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391626004668 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391626004669 DNA-binding site [nucleotide binding]; DNA binding site 391626004670 RNA-binding motif; other site 391626004671 putative MFS family transporter protein; Provisional; Region: PRK03633 391626004672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626004673 putative substrate translocation pore; other site 391626004674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626004675 Transposase; Region: HTH_Tnp_1; cl17663 391626004676 putative transposase OrfB; Reviewed; Region: PHA02517 391626004677 HTH-like domain; Region: HTH_21; pfam13276 391626004678 Integrase core domain; Region: rve; pfam00665 391626004679 Integrase core domain; Region: rve_3; pfam13683 391626004680 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626004681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626004682 Walker A/P-loop; other site 391626004683 ATP binding site [chemical binding]; other site 391626004684 Q-loop/lid; other site 391626004685 ABC transporter signature motif; other site 391626004686 Walker B; other site 391626004687 D-loop; other site 391626004688 H-loop/switch region; other site 391626004689 TOBE domain; Region: TOBE_2; pfam08402 391626004690 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004692 dimer interface [polypeptide binding]; other site 391626004693 conserved gate region; other site 391626004694 putative PBP binding loops; other site 391626004695 ABC-ATPase subunit interface; other site 391626004696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626004697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004698 dimer interface [polypeptide binding]; other site 391626004699 conserved gate region; other site 391626004700 putative PBP binding loops; other site 391626004701 ABC-ATPase subunit interface; other site 391626004702 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626004703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626004704 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391626004705 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 391626004706 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391626004707 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391626004708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 391626004709 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391626004710 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 391626004711 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391626004712 H+ Antiporter protein; Region: 2A0121; TIGR00900 391626004713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626004714 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391626004715 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626004716 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626004717 catalytic residue [active] 391626004718 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626004719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626004720 putative DNA binding site [nucleotide binding]; other site 391626004721 putative Zn2+ binding site [ion binding]; other site 391626004722 AsnC family; Region: AsnC_trans_reg; pfam01037 391626004723 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626004724 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626004725 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626004726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626004727 Transposase; Region: HTH_Tnp_1; pfam01527 391626004728 Restriction endonuclease; Region: Mrr_cat; pfam04471 391626004729 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391626004730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626004731 non-specific DNA binding site [nucleotide binding]; other site 391626004732 salt bridge; other site 391626004733 sequence-specific DNA binding site [nucleotide binding]; other site 391626004734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626004735 Integrase core domain; Region: rve; pfam00665 391626004736 transposase/IS protein; Provisional; Region: PRK09183 391626004737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626004738 Walker A motif; other site 391626004739 ATP binding site [chemical binding]; other site 391626004740 Walker B motif; other site 391626004741 arginine finger; other site 391626004742 integrase; Provisional; Region: PRK09692 391626004743 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391626004744 active site 391626004745 Int/Topo IB signature motif; other site 391626004746 AAA domain; Region: AAA_25; pfam13481 391626004747 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626004748 Walker A motif; other site 391626004749 ATP binding site [chemical binding]; other site 391626004750 Walker B motif; other site 391626004751 DNA topoisomerase III; Provisional; Region: PRK07726 391626004752 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 391626004753 active site 391626004754 interdomain interaction site; other site 391626004755 putative metal-binding site [ion binding]; other site 391626004756 nucleotide binding site [chemical binding]; other site 391626004757 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 391626004758 domain I; other site 391626004759 DNA binding groove [nucleotide binding] 391626004760 phosphate binding site [ion binding]; other site 391626004761 domain II; other site 391626004762 domain III; other site 391626004763 nucleotide binding site [chemical binding]; other site 391626004764 catalytic site [active] 391626004765 domain IV; other site 391626004766 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 391626004767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391626004768 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391626004769 agmatinase; Region: agmatinase; TIGR01230 391626004770 oligomer interface [polypeptide binding]; other site 391626004771 putative active site [active] 391626004772 Mn binding site [ion binding]; other site 391626004773 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391626004774 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626004775 NAD(P) binding site [chemical binding]; other site 391626004776 active site 391626004777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626004778 classical (c) SDRs; Region: SDR_c; cd05233 391626004779 NAD(P) binding site [chemical binding]; other site 391626004780 active site 391626004781 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 391626004782 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626004783 Walker A/P-loop; other site 391626004784 ATP binding site [chemical binding]; other site 391626004785 Q-loop/lid; other site 391626004786 ABC transporter signature motif; other site 391626004787 Walker B; other site 391626004788 D-loop; other site 391626004789 H-loop/switch region; other site 391626004790 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626004791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004792 dimer interface [polypeptide binding]; other site 391626004793 conserved gate region; other site 391626004794 putative PBP binding loops; other site 391626004795 ABC-ATPase subunit interface; other site 391626004796 NMT1/THI5 like; Region: NMT1; pfam09084 391626004797 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 391626004798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626004799 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626004800 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 391626004801 active site 391626004802 catalytic site [active] 391626004803 Zn binding site [ion binding]; other site 391626004804 tetramer interface [polypeptide binding]; other site 391626004805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626004806 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391626004807 Coenzyme A binding pocket [chemical binding]; other site 391626004808 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391626004809 MltA-interacting protein MipA; Region: MipA; cl01504 391626004810 LytTr DNA-binding domain; Region: LytTR; smart00850 391626004811 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391626004812 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 391626004813 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 391626004814 active site 391626004815 NTP binding site [chemical binding]; other site 391626004816 metal binding triad [ion binding]; metal-binding site 391626004817 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 391626004818 ThiF family; Region: ThiF; pfam00899 391626004819 ATP binding site [chemical binding]; other site 391626004820 substrate interface [chemical binding]; other site 391626004821 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 391626004822 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 391626004823 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626004824 active site 391626004825 catalytic residues [active] 391626004826 DNA binding site [nucleotide binding] 391626004827 Int/Topo IB signature motif; other site 391626004828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626004829 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626004830 substrate binding pocket [chemical binding]; other site 391626004831 membrane-bound complex binding site; other site 391626004832 hinge residues; other site 391626004833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004834 dimer interface [polypeptide binding]; other site 391626004835 conserved gate region; other site 391626004836 putative PBP binding loops; other site 391626004837 ABC-ATPase subunit interface; other site 391626004838 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391626004839 LrgB-like family; Region: LrgB; pfam04172 391626004840 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626004841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626004842 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626004843 dimerization interface [polypeptide binding]; other site 391626004844 putative Zn2+ binding site [ion binding]; other site 391626004845 putative DNA binding site [nucleotide binding]; other site 391626004846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626004847 Integrase core domain; Region: rve; pfam00665 391626004848 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391626004849 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391626004850 homotrimer interaction site [polypeptide binding]; other site 391626004851 putative active site [active] 391626004852 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391626004853 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391626004854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626004855 Walker A/P-loop; other site 391626004856 ATP binding site [chemical binding]; other site 391626004857 Q-loop/lid; other site 391626004858 ABC transporter signature motif; other site 391626004859 Walker B; other site 391626004860 D-loop; other site 391626004861 H-loop/switch region; other site 391626004862 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626004863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626004864 dimer interface [polypeptide binding]; other site 391626004865 conserved gate region; other site 391626004866 putative PBP binding loops; other site 391626004867 ABC-ATPase subunit interface; other site 391626004868 cytosine deaminase-like protein; Validated; Region: PRK07583 391626004869 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 391626004870 active site 391626004871 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391626004872 FAD binding domain; Region: FAD_binding_4; pfam01565 391626004873 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 391626004874 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626004875 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 391626004876 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 391626004877 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 391626004878 Creatinine amidohydrolase; Region: Creatininase; pfam02633 391626004879 HTH-like domain; Region: HTH_21; pfam13276 391626004880 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626004881 Integrase core domain; Region: rve; pfam00665 391626004882 Integrase core domain; Region: rve_3; pfam13683 391626004883 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626004884 Transposase; Region: HTH_Tnp_1; cl17663 391626004885 Family description; Region: UvrD_C_2; pfam13538 391626004886 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391626004887 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391626004888 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 391626004889 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391626004890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626004891 Integrase core domain; Region: rve; pfam00665 391626004892 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626004893 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626004894 Integrase core domain; Region: rve; pfam00665 391626004895 YaeQ protein; Region: YaeQ; pfam07152 391626004896 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 391626004897 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 391626004898 active site 391626004899 catalytic site [active] 391626004900 substrate binding site [chemical binding]; other site 391626004901 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626004902 active site 391626004903 DNA binding site [nucleotide binding] 391626004904 Int/Topo IB signature motif; other site 391626004905 Helix-turn-helix domain; Region: HTH_17; pfam12728 391626004906 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391626004907 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 391626004908 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 391626004909 putative active site [active] 391626004910 putative NTP binding site [chemical binding]; other site 391626004911 putative nucleic acid binding site [nucleotide binding]; other site 391626004912 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 391626004913 putative active site [active] 391626004914 putative NTP binding site [chemical binding]; other site 391626004915 putative nucleic acid binding site [nucleotide binding]; other site 391626004916 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391626004917 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 391626004918 putative active site [active] 391626004919 putative FMN binding site [chemical binding]; other site 391626004920 putative substrate binding site [chemical binding]; other site 391626004921 putative catalytic residue [active] 391626004922 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626004923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626004924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626004925 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 391626004926 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626004927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626004928 NAD(P) binding site [chemical binding]; other site 391626004929 active site 391626004930 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626004931 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626004932 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626004933 putative effector binding pocket; other site 391626004934 dimerization interface [polypeptide binding]; other site 391626004935 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626004936 Integrase core domain; Region: rve; pfam00665 391626004937 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626004938 Catalytic site [active] 391626004939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626004940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626004941 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391626004942 dimerization interface [polypeptide binding]; other site 391626004943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626004944 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391626004945 NAD(P) binding site [chemical binding]; other site 391626004946 active site 391626004947 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391626004948 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391626004949 active site 391626004950 catalytic tetrad [active] 391626004951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626004952 Integrase core domain; Region: rve; pfam00665 391626004953 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626004954 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 391626004955 ligand binding site [chemical binding]; other site 391626004956 regulator interaction site; other site 391626004957 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391626004958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626004959 active site 391626004960 phosphorylation site [posttranslational modification] 391626004961 dimerization interface [polypeptide binding]; other site 391626004962 ANTAR domain; Region: ANTAR; pfam03861 391626004963 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626004964 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 391626004965 putative ligand binding site [chemical binding]; other site 391626004966 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626004967 TM-ABC transporter signature motif; other site 391626004968 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626004969 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626004970 TM-ABC transporter signature motif; other site 391626004971 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391626004972 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626004973 Walker A/P-loop; other site 391626004974 ATP binding site [chemical binding]; other site 391626004975 Q-loop/lid; other site 391626004976 ABC transporter signature motif; other site 391626004977 Walker B; other site 391626004978 D-loop; other site 391626004979 H-loop/switch region; other site 391626004980 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626004981 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626004982 Walker A/P-loop; other site 391626004983 ATP binding site [chemical binding]; other site 391626004984 Q-loop/lid; other site 391626004985 ABC transporter signature motif; other site 391626004986 Walker B; other site 391626004987 D-loop; other site 391626004988 H-loop/switch region; other site 391626004989 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 391626004990 tropinone reductase; Provisional; Region: PRK09242 391626004991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626004992 NAD(P) binding site [chemical binding]; other site 391626004993 active site 391626004994 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391626004995 Amidase; Region: Amidase; cl11426 391626004996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626004997 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626004998 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626004999 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626005000 active site 391626005001 DNA binding site [nucleotide binding] 391626005002 Int/Topo IB signature motif; other site 391626005003 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391626005004 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391626005005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626005006 DNA-binding site [nucleotide binding]; DNA binding site 391626005007 FCD domain; Region: FCD; pfam07729 391626005008 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391626005009 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391626005010 putative ligand binding site [chemical binding]; other site 391626005011 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626005012 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005013 Walker A/P-loop; other site 391626005014 ATP binding site [chemical binding]; other site 391626005015 ABC transporter signature motif; other site 391626005016 Walker B; other site 391626005017 D-loop; other site 391626005018 H-loop/switch region; other site 391626005019 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626005020 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626005021 TM-ABC transporter signature motif; other site 391626005022 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391626005023 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626005024 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626005025 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391626005026 tetramerization interface [polypeptide binding]; other site 391626005027 NAD(P) binding site [chemical binding]; other site 391626005028 catalytic residues [active] 391626005029 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391626005030 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391626005031 active site pocket [active] 391626005032 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391626005033 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391626005034 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 391626005035 AAA domain; Region: AAA_21; pfam13304 391626005036 AAA domain; Region: AAA_30; pfam13604 391626005037 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 391626005038 AAA domain; Region: AAA_12; pfam13087 391626005039 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 391626005040 putative active site [active] 391626005041 catalytic site [active] 391626005042 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 391626005043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626005044 ATP binding site [chemical binding]; other site 391626005045 putative Mg++ binding site [ion binding]; other site 391626005046 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391626005047 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 391626005048 AAA domain; Region: AAA_22; pfam13401 391626005049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626005050 active site 391626005051 DNA binding site [nucleotide binding] 391626005052 Int/Topo IB signature motif; other site 391626005053 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626005054 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626005055 dimerization interface [polypeptide binding]; other site 391626005056 putative DNA binding site [nucleotide binding]; other site 391626005057 putative Zn2+ binding site [ion binding]; other site 391626005058 AsnC family; Region: AsnC_trans_reg; pfam01037 391626005059 methionine gamma-lyase; Provisional; Region: PRK07503 391626005060 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391626005061 homodimer interface [polypeptide binding]; other site 391626005062 substrate-cofactor binding pocket; other site 391626005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626005064 catalytic residue [active] 391626005065 alpha-ketoglutarate dehydrogenase; Region: AKGDH_not_PDH; TIGR03186 391626005066 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626005067 TPP-binding site [chemical binding]; other site 391626005068 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391626005069 PYR/PP interface [polypeptide binding]; other site 391626005070 dimer interface [polypeptide binding]; other site 391626005071 TPP binding site [chemical binding]; other site 391626005072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626005073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626005074 putative substrate translocation pore; other site 391626005075 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 391626005076 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391626005077 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 391626005078 conserved cys residue [active] 391626005079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626005080 LrgB-like family; Region: LrgB; pfam04172 391626005081 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391626005082 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391626005083 active site pocket [active] 391626005084 choline dehydrogenase; Validated; Region: PRK02106 391626005085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626005086 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626005087 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626005088 Catalytic site [active] 391626005089 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 391626005090 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391626005091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626005092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391626005093 active site 391626005094 metal binding site [ion binding]; metal-binding site 391626005095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626005096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626005097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391626005098 dimerization interface [polypeptide binding]; other site 391626005099 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 391626005100 Protein of unknown function (DUF971); Region: DUF971; cl01414 391626005101 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 391626005102 substrate binding pocket [chemical binding]; other site 391626005103 active site 391626005104 iron coordination sites [ion binding]; other site 391626005105 Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834 391626005106 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626005107 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626005108 non-specific DNA binding site [nucleotide binding]; other site 391626005109 salt bridge; other site 391626005110 sequence-specific DNA binding site [nucleotide binding]; other site 391626005111 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626005112 putative DNA binding site [nucleotide binding]; other site 391626005113 putative Zn2+ binding site [ion binding]; other site 391626005114 WYL domain; Region: WYL; pfam13280 391626005115 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391626005116 homotrimer interaction site [polypeptide binding]; other site 391626005117 putative active site [active] 391626005118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005119 Walker A/P-loop; other site 391626005120 ATP binding site [chemical binding]; other site 391626005121 Q-loop/lid; other site 391626005122 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391626005123 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391626005124 catalytic residues [active] 391626005125 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 391626005126 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 391626005127 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 391626005128 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391626005129 DNA binding residues [nucleotide binding] 391626005130 putative dimer interface [polypeptide binding]; other site 391626005131 putative metal binding residues [ion binding]; other site 391626005132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626005133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626005134 NAD(P) binding site [chemical binding]; other site 391626005135 active site 391626005136 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626005137 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626005138 putative DNA binding site [nucleotide binding]; other site 391626005139 putative Zn2+ binding site [ion binding]; other site 391626005140 AsnC family; Region: AsnC_trans_reg; pfam01037 391626005141 Cupin domain; Region: Cupin_2; cl17218 391626005142 LysE type translocator; Region: LysE; cl00565 391626005143 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626005144 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626005145 DNA binding site [nucleotide binding] 391626005146 LrgB-like family; Region: LrgB; pfam04172 391626005147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626005148 active site 391626005149 DNA binding site [nucleotide binding] 391626005150 Int/Topo IB signature motif; other site 391626005151 Helix-turn-helix domain; Region: HTH_17; pfam12728 391626005152 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391626005153 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626005154 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626005155 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391626005156 ANTAR domain; Region: ANTAR; pfam03861 391626005157 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626005158 Periplasmic binding protein domain; Region: Peripla_BP_5; pfam13433 391626005159 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391626005160 Amidase; Region: Amidase; pfam01425 391626005161 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626005162 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626005163 Walker A/P-loop; other site 391626005164 ATP binding site [chemical binding]; other site 391626005165 Q-loop/lid; other site 391626005166 ABC transporter signature motif; other site 391626005167 Walker B; other site 391626005168 D-loop; other site 391626005169 H-loop/switch region; other site 391626005170 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626005171 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626005172 TM-ABC transporter signature motif; other site 391626005173 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626005174 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391626005175 Walker A/P-loop; other site 391626005176 ATP binding site [chemical binding]; other site 391626005177 Q-loop/lid; other site 391626005178 ABC transporter signature motif; other site 391626005179 Walker B; other site 391626005180 D-loop; other site 391626005181 H-loop/switch region; other site 391626005182 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626005183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626005184 TM-ABC transporter signature motif; other site 391626005185 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626005186 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391626005187 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626005188 Catalytic site [active] 391626005189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626005190 Integrase core domain; Region: rve; pfam00665 391626005191 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391626005192 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391626005193 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391626005194 putative active site [active] 391626005195 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626005196 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391626005197 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391626005198 ligand binding site [chemical binding]; other site 391626005199 NAD binding site [chemical binding]; other site 391626005200 dimerization interface [polypeptide binding]; other site 391626005201 catalytic site [active] 391626005202 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 391626005203 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391626005204 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626005205 tetramerization interface [polypeptide binding]; other site 391626005206 NAD(P) binding site [chemical binding]; other site 391626005207 catalytic residues [active] 391626005208 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391626005209 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626005210 PYR/PP interface [polypeptide binding]; other site 391626005211 dimer interface [polypeptide binding]; other site 391626005212 TPP binding site [chemical binding]; other site 391626005213 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626005214 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626005215 TPP-binding site [chemical binding]; other site 391626005216 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391626005217 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391626005218 Homeodomain-like domain; Region: HTH_23; pfam13384 391626005219 Winged helix-turn helix; Region: HTH_29; pfam13551 391626005220 Winged helix-turn helix; Region: HTH_33; pfam13592 391626005221 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391626005222 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391626005223 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391626005224 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626005225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626005226 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626005227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626005228 dimer interface [polypeptide binding]; other site 391626005229 conserved gate region; other site 391626005230 putative PBP binding loops; other site 391626005231 ABC-ATPase subunit interface; other site 391626005232 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626005233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626005234 dimer interface [polypeptide binding]; other site 391626005235 conserved gate region; other site 391626005236 putative PBP binding loops; other site 391626005237 ABC-ATPase subunit interface; other site 391626005238 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626005239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005240 Walker A/P-loop; other site 391626005241 ATP binding site [chemical binding]; other site 391626005242 Q-loop/lid; other site 391626005243 ABC transporter signature motif; other site 391626005244 Walker B; other site 391626005245 D-loop; other site 391626005246 H-loop/switch region; other site 391626005247 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626005248 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391626005249 Walker A/P-loop; other site 391626005250 ATP binding site [chemical binding]; other site 391626005251 Q-loop/lid; other site 391626005252 ABC transporter signature motif; other site 391626005253 Walker B; other site 391626005254 D-loop; other site 391626005255 H-loop/switch region; other site 391626005256 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626005257 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626005258 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626005259 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 391626005260 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 391626005261 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391626005262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626005263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005264 Walker A/P-loop; other site 391626005265 ATP binding site [chemical binding]; other site 391626005266 Q-loop/lid; other site 391626005267 ABC transporter signature motif; other site 391626005268 Walker B; other site 391626005269 D-loop; other site 391626005270 H-loop/switch region; other site 391626005271 AMP-binding domain protein; Validated; Region: PRK07529 391626005272 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626005273 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 391626005274 acyl-activating enzyme (AAE) consensus motif; other site 391626005275 putative AMP binding site [chemical binding]; other site 391626005276 putative active site [active] 391626005277 putative CoA binding site [chemical binding]; other site 391626005278 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391626005279 Transposase; Region: HTH_Tnp_1; pfam01527 391626005280 Integrase core domain; Region: rve; pfam00665 391626005281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626005282 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 391626005283 putative aldolase; Validated; Region: PRK08130 391626005284 intersubunit interface [polypeptide binding]; other site 391626005285 active site 391626005286 Zn2+ binding site [ion binding]; other site 391626005287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 391626005288 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 391626005289 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626005290 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626005291 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 391626005292 DctM-like transporters; Region: DctM; pfam06808 391626005293 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626005294 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626005295 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626005296 DNA binding site [nucleotide binding] 391626005297 domain linker motif; other site 391626005298 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391626005299 putative ligand binding site [chemical binding]; other site 391626005300 putative dimerization interface [polypeptide binding]; other site 391626005301 Uncharacterized conserved protein [Function unknown]; Region: COG3586 391626005302 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626005303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626005304 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391626005305 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391626005306 Ligand Binding Site [chemical binding]; other site 391626005307 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626005308 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391626005309 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626005310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626005311 dimer interface [polypeptide binding]; other site 391626005312 conserved gate region; other site 391626005313 putative PBP binding loops; other site 391626005314 ABC-ATPase subunit interface; other site 391626005315 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 391626005316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626005317 dimer interface [polypeptide binding]; other site 391626005318 conserved gate region; other site 391626005319 ABC-ATPase subunit interface; other site 391626005320 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391626005321 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626005322 Walker A/P-loop; other site 391626005323 ATP binding site [chemical binding]; other site 391626005324 Q-loop/lid; other site 391626005325 ABC transporter signature motif; other site 391626005326 Walker B; other site 391626005327 D-loop; other site 391626005328 H-loop/switch region; other site 391626005329 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626005330 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391626005331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626005332 Walker A/P-loop; other site 391626005333 ATP binding site [chemical binding]; other site 391626005334 Q-loop/lid; other site 391626005335 ABC transporter signature motif; other site 391626005336 Walker B; other site 391626005337 D-loop; other site 391626005338 H-loop/switch region; other site 391626005339 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626005340 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626005341 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626005342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391626005343 Serine hydrolase; Region: Ser_hydrolase; cl17834 391626005344 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 391626005345 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626005346 putative metal binding site [ion binding]; other site 391626005347 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391626005348 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391626005349 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391626005350 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391626005351 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391626005352 Hint domain; Region: Hint_2; pfam13403 391626005353 HTH-like domain; Region: HTH_21; pfam13276 391626005354 Transposase; Region: HTH_Tnp_1; pfam01527 391626005355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626005356 putative transposase OrfB; Reviewed; Region: PHA02517 391626005357 HTH-like domain; Region: HTH_21; pfam13276 391626005358 Integrase core domain; Region: rve; pfam00665 391626005359 Integrase core domain; Region: rve_2; pfam13333 391626005360 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391626005361 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391626005362 substrate binding site [chemical binding]; other site 391626005363 catalytic Zn binding site [ion binding]; other site 391626005364 NAD binding site [chemical binding]; other site 391626005365 structural Zn binding site [ion binding]; other site 391626005366 dimer interface [polypeptide binding]; other site 391626005367 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391626005368 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626005369 NAD binding site [chemical binding]; other site 391626005370 catalytic residues [active] 391626005371 Transcriptional activator [Transcription]; Region: ChrR; COG3806 391626005372 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391626005373 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391626005374 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391626005375 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391626005376 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391626005377 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391626005378 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 391626005379 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391626005380 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391626005381 dimer interface [polypeptide binding]; other site 391626005382 active site 391626005383 effector binding site; other site 391626005384 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 391626005385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391626005386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626005387 metal binding site [ion binding]; metal-binding site 391626005388 active site 391626005389 I-site; other site 391626005390 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626005391 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 391626005392 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626005393 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 391626005394 active site 391626005395 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 391626005396 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391626005397 Predicted transporter component [General function prediction only]; Region: COG2391 391626005398 Sulphur transport; Region: Sulf_transp; pfam04143 391626005399 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 391626005400 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 391626005401 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391626005402 active site 391626005403 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 391626005404 A new structural DNA glycosylase; Region: AlkD_like; cd06561 391626005405 active site 391626005406 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391626005407 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 391626005408 glutaminase active site [active] 391626005409 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391626005410 dimer interface [polypeptide binding]; other site 391626005411 active site 391626005412 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391626005413 dimer interface [polypeptide binding]; other site 391626005414 active site 391626005415 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 391626005416 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391626005417 Substrate binding site; other site 391626005418 Mg++ binding site; other site 391626005419 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391626005420 active site 391626005421 substrate binding site [chemical binding]; other site 391626005422 CoA binding site [chemical binding]; other site 391626005423 phosphoglycolate phosphatase; Provisional; Region: PRK13222 391626005424 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391626005425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626005426 motif II; other site 391626005427 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391626005428 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626005429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626005430 catalytic residue [active] 391626005431 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626005432 Catalytic site [active] 391626005433 isovaleryl-CoA dehydrogenase; Region: PLN02519 391626005434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626005435 active site 391626005436 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 391626005437 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 391626005438 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391626005439 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391626005440 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391626005441 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626005442 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 391626005443 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391626005444 carboxyltransferase (CT) interaction site; other site 391626005445 biotinylation site [posttranslational modification]; other site 391626005446 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 391626005447 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391626005448 active site 391626005449 catalytic residues [active] 391626005450 metal binding site [ion binding]; metal-binding site 391626005451 enoyl-CoA hydratase; Provisional; Region: PRK07468 391626005452 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626005453 substrate binding site [chemical binding]; other site 391626005454 oxyanion hole (OAH) forming residues; other site 391626005455 trimer interface [polypeptide binding]; other site 391626005456 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 391626005457 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391626005458 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 391626005459 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 391626005460 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 391626005461 NADH dehydrogenase subunit D; Validated; Region: PRK06075 391626005462 NADH dehydrogenase subunit E; Validated; Region: PRK07539 391626005463 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 391626005464 putative dimer interface [polypeptide binding]; other site 391626005465 [2Fe-2S] cluster binding site [ion binding]; other site 391626005466 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391626005467 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391626005468 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 391626005469 SLBB domain; Region: SLBB; pfam10531 391626005470 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391626005471 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 391626005472 NADH dehydrogenase subunit G; Validated; Region: PRK09130 391626005473 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626005474 catalytic loop [active] 391626005475 iron binding site [ion binding]; other site 391626005476 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391626005477 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391626005478 molybdopterin cofactor binding site; other site 391626005479 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 391626005480 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391626005481 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391626005482 4Fe-4S binding domain; Region: Fer4; pfam00037 391626005483 4Fe-4S binding domain; Region: Fer4; pfam00037 391626005484 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391626005485 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391626005486 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 391626005487 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 391626005488 NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; Region: NuoM; COG1008 391626005489 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391626005490 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626005491 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391626005492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626005493 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391626005494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626005495 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391626005496 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 391626005497 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391626005498 pantothenate kinase; Reviewed; Region: PRK13318 391626005499 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 391626005500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391626005501 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 391626005502 helicase 45; Provisional; Region: PTZ00424 391626005503 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391626005504 ATP binding site [chemical binding]; other site 391626005505 Mg++ binding site [ion binding]; other site 391626005506 motif III; other site 391626005507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626005508 nucleotide binding region [chemical binding]; other site 391626005509 ATP-binding site [chemical binding]; other site 391626005510 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 391626005511 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 391626005512 G1 box; other site 391626005513 putative GEF interaction site [polypeptide binding]; other site 391626005514 GTP/Mg2+ binding site [chemical binding]; other site 391626005515 Switch I region; other site 391626005516 G2 box; other site 391626005517 G3 box; other site 391626005518 Switch II region; other site 391626005519 G4 box; other site 391626005520 G5 box; other site 391626005521 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 391626005522 Hint domain; Region: Hint_2; pfam13403 391626005523 short chain dehydrogenase; Provisional; Region: PRK08339 391626005524 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 391626005525 putative NAD(P) binding site [chemical binding]; other site 391626005526 putative active site [active] 391626005527 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626005528 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391626005529 Walker A/P-loop; other site 391626005530 ATP binding site [chemical binding]; other site 391626005531 Q-loop/lid; other site 391626005532 ABC transporter signature motif; other site 391626005533 Walker B; other site 391626005534 D-loop; other site 391626005535 H-loop/switch region; other site 391626005536 TOBE domain; Region: TOBE_2; pfam08402 391626005537 HTH domain; Region: HTH_11; pfam08279 391626005538 WYL domain; Region: WYL; pfam13280 391626005539 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391626005540 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391626005541 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 391626005542 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 391626005543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626005544 Walker A motif; other site 391626005545 ATP binding site [chemical binding]; other site 391626005546 Walker B motif; other site 391626005547 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391626005548 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 391626005549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626005550 S-adenosylmethionine binding site [chemical binding]; other site 391626005551 Survival protein SurE; Region: SurE; cl00448 391626005552 classical (c) SDRs; Region: SDR_c; cd05233 391626005553 NAD(P) binding site [chemical binding]; other site 391626005554 active site 391626005555 amidophosphoribosyltransferase; Provisional; Region: PRK09123 391626005556 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391626005557 active site 391626005558 tetramer interface [polypeptide binding]; other site 391626005559 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626005560 active site 391626005561 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 391626005562 Colicin V production protein; Region: Colicin_V; pfam02674 391626005563 DNA repair protein RadA; Provisional; Region: PRK11823 391626005564 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 391626005565 Walker A motif/ATP binding site; other site 391626005566 ATP binding site [chemical binding]; other site 391626005567 Walker B motif; other site 391626005568 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391626005569 Paraquat-inducible protein A; Region: PqiA; pfam04403 391626005570 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391626005571 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 391626005572 Walker A/P-loop; other site 391626005573 ATP binding site [chemical binding]; other site 391626005574 Q-loop/lid; other site 391626005575 ABC transporter signature motif; other site 391626005576 Walker B; other site 391626005577 D-loop; other site 391626005578 H-loop/switch region; other site 391626005579 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391626005580 Permease; Region: Permease; pfam02405 391626005581 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 391626005582 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 391626005583 active site 391626005584 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391626005585 dimer interface [polypeptide binding]; other site 391626005586 substrate binding site [chemical binding]; other site 391626005587 catalytic residues [active] 391626005588 replicative DNA helicase; Provisional; Region: PRK09165 391626005589 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391626005590 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391626005591 Walker A motif; other site 391626005592 ATP binding site [chemical binding]; other site 391626005593 Walker B motif; other site 391626005594 DNA binding loops [nucleotide binding] 391626005595 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626005596 active site 391626005597 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 391626005598 active site 391626005599 substrate binding pocket [chemical binding]; other site 391626005600 dimer interface [polypeptide binding]; other site 391626005601 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391626005602 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626005603 FAD binding site [chemical binding]; other site 391626005604 substrate binding pocket [chemical binding]; other site 391626005605 catalytic base [active] 391626005606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626005607 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391626005608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005609 Walker A/P-loop; other site 391626005610 ATP binding site [chemical binding]; other site 391626005611 Q-loop/lid; other site 391626005612 ABC transporter signature motif; other site 391626005613 Walker B; other site 391626005614 D-loop; other site 391626005615 H-loop/switch region; other site 391626005616 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391626005617 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391626005618 putative di-iron ligands [ion binding]; other site 391626005619 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 391626005620 Protein export membrane protein; Region: SecD_SecF; cl14618 391626005621 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626005622 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626005623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 391626005624 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 391626005625 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 391626005626 Trp docking motif [polypeptide binding]; other site 391626005627 active site 391626005628 PQQ-like domain; Region: PQQ_2; pfam13360 391626005629 PQQ-like domain; Region: PQQ_2; pfam13360 391626005630 GTP-binding protein Der; Reviewed; Region: PRK00093 391626005631 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 391626005632 G1 box; other site 391626005633 GTP/Mg2+ binding site [chemical binding]; other site 391626005634 Switch I region; other site 391626005635 G2 box; other site 391626005636 Switch II region; other site 391626005637 G3 box; other site 391626005638 G4 box; other site 391626005639 G5 box; other site 391626005640 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 391626005641 G1 box; other site 391626005642 GTP/Mg2+ binding site [chemical binding]; other site 391626005643 Switch I region; other site 391626005644 G2 box; other site 391626005645 G3 box; other site 391626005646 Switch II region; other site 391626005647 G4 box; other site 391626005648 G5 box; other site 391626005649 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391626005650 seryl-tRNA synthetase; Provisional; Region: PRK05431 391626005651 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 391626005652 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 391626005653 dimer interface [polypeptide binding]; other site 391626005654 active site 391626005655 motif 1; other site 391626005656 motif 2; other site 391626005657 motif 3; other site 391626005658 Preprotein translocase subunit; Region: YajC; pfam02699 391626005659 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 391626005660 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 391626005661 Protein export membrane protein; Region: SecD_SecF; pfam02355 391626005662 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 391626005663 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 391626005664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005665 Walker A/P-loop; other site 391626005666 ATP binding site [chemical binding]; other site 391626005667 Q-loop/lid; other site 391626005668 ABC transporter signature motif; other site 391626005669 Walker B; other site 391626005670 D-loop; other site 391626005671 H-loop/switch region; other site 391626005672 heme exporter protein CcmB; Region: ccmB; TIGR01190 391626005673 heme exporter protein CcmC; Region: ccmC; TIGR01191 391626005674 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 391626005675 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391626005676 catalytic residues [active] 391626005677 central insert; other site 391626005678 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391626005679 Amidinotransferase; Region: Amidinotransf; cl12043 391626005680 aconitate hydratase; Validated; Region: PRK09277 391626005681 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 391626005682 substrate binding site [chemical binding]; other site 391626005683 ligand binding site [chemical binding]; other site 391626005684 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 391626005685 substrate binding site [chemical binding]; other site 391626005686 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 391626005687 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391626005688 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391626005689 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391626005690 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391626005691 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391626005692 FliG C-terminal domain; Region: FliG_C; pfam01706 391626005693 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391626005694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391626005695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626005696 DNA binding residues [nucleotide binding] 391626005697 dimerization interface [polypeptide binding]; other site 391626005698 Autoinducer synthetase; Region: Autoind_synth; cl17404 391626005699 adenylosuccinate lyase; Provisional; Region: PRK07492 391626005700 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 391626005701 tetramer interface [polypeptide binding]; other site 391626005702 active site 391626005703 BioY family; Region: BioY; pfam02632 391626005704 Transposase; Region: HTH_Tnp_1; cl17663 391626005705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626005706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626005707 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626005708 putative effector binding pocket; other site 391626005709 dimerization interface [polypeptide binding]; other site 391626005710 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391626005711 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391626005712 dimer interface [polypeptide binding]; other site 391626005713 PYR/PP interface [polypeptide binding]; other site 391626005714 TPP binding site [chemical binding]; other site 391626005715 substrate binding site [chemical binding]; other site 391626005716 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391626005717 TPP-binding site [chemical binding]; other site 391626005718 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391626005719 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391626005720 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 391626005721 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391626005722 CcmE; Region: CcmE; pfam03100 391626005723 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 391626005724 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 391626005725 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 391626005726 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 391626005727 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 391626005728 enoyl-CoA hydratase; Provisional; Region: PRK08140 391626005729 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626005730 substrate binding site [chemical binding]; other site 391626005731 oxyanion hole (OAH) forming residues; other site 391626005732 trimer interface [polypeptide binding]; other site 391626005733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626005734 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626005735 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391626005736 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391626005737 dimer interface [polypeptide binding]; other site 391626005738 active site 391626005739 citrylCoA binding site [chemical binding]; other site 391626005740 NADH binding [chemical binding]; other site 391626005741 cationic pore residues; other site 391626005742 oxalacetate/citrate binding site [chemical binding]; other site 391626005743 coenzyme A binding site [chemical binding]; other site 391626005744 catalytic triad [active] 391626005745 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391626005746 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626005747 active site 391626005748 HIGH motif; other site 391626005749 nucleotide binding site [chemical binding]; other site 391626005750 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391626005751 active site 391626005752 KMSKS motif; other site 391626005753 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 391626005754 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 391626005755 Competence protein; Region: Competence; pfam03772 391626005756 LexA repressor; Validated; Region: PRK00215 391626005757 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 391626005758 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626005759 Catalytic site [active] 391626005760 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391626005761 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391626005762 dimer interface [polypeptide binding]; other site 391626005763 putative functional site; other site 391626005764 putative MPT binding site; other site 391626005765 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 391626005766 trimer interface [polypeptide binding]; other site 391626005767 dimer interface [polypeptide binding]; other site 391626005768 putative active site [active] 391626005769 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391626005770 active site 391626005771 ribulose/triose binding site [chemical binding]; other site 391626005772 phosphate binding site [ion binding]; other site 391626005773 substrate (anthranilate) binding pocket [chemical binding]; other site 391626005774 product (indole) binding pocket [chemical binding]; other site 391626005775 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 391626005776 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391626005777 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391626005778 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391626005779 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391626005780 glutamine binding [chemical binding]; other site 391626005781 catalytic triad [active] 391626005782 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 391626005783 NodB motif; other site 391626005784 putative active site [active] 391626005785 putative catalytic site [active] 391626005786 Zn binding site [ion binding]; other site 391626005787 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391626005788 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 391626005789 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391626005790 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 391626005791 hypothetical protein; Provisional; Region: PRK07550 391626005792 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626005793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626005794 homodimer interface [polypeptide binding]; other site 391626005795 catalytic residue [active] 391626005796 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626005797 active site 391626005798 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 391626005799 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391626005800 NAD binding site [chemical binding]; other site 391626005801 homotetramer interface [polypeptide binding]; other site 391626005802 homodimer interface [polypeptide binding]; other site 391626005803 substrate binding site [chemical binding]; other site 391626005804 active site 391626005805 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391626005806 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 391626005807 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391626005808 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391626005809 DNA-binding site [nucleotide binding]; DNA binding site 391626005810 RNA-binding motif; other site 391626005811 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391626005812 DNA-binding site [nucleotide binding]; DNA binding site 391626005813 RNA-binding motif; other site 391626005814 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 391626005815 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626005816 active site 391626005817 Int/Topo IB signature motif; other site 391626005818 DNA binding site [nucleotide binding] 391626005819 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391626005820 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 391626005821 putative active site [active] 391626005822 catalytic triad [active] 391626005823 putative dimer interface [polypeptide binding]; other site 391626005824 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 391626005825 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626005826 active site 391626005827 Predicted transcriptional regulators [Transcription]; Region: COG1733 391626005828 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 391626005829 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 391626005830 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 391626005831 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391626005832 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391626005833 active site 391626005834 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391626005835 TSCPD domain; Region: TSCPD; pfam12637 391626005836 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 391626005837 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391626005838 C-terminal domain interface [polypeptide binding]; other site 391626005839 GSH binding site (G-site) [chemical binding]; other site 391626005840 dimer interface [polypeptide binding]; other site 391626005841 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626005842 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626005843 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626005844 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626005845 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626005846 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 391626005847 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391626005848 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626005849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626005850 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391626005851 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626005852 catalytic loop [active] 391626005853 iron binding site [ion binding]; other site 391626005854 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626005855 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391626005856 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626005857 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626005858 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626005859 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 391626005860 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626005861 enolase; Provisional; Region: eno; PRK00077 391626005862 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391626005863 dimer interface [polypeptide binding]; other site 391626005864 metal binding site [ion binding]; metal-binding site 391626005865 substrate binding pocket [chemical binding]; other site 391626005866 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 391626005867 putative metal binding site [ion binding]; other site 391626005868 Uncharacterized conserved protein [Function unknown]; Region: COG1432 391626005869 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 391626005870 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391626005871 metal binding site 2 [ion binding]; metal-binding site 391626005872 putative DNA binding helix; other site 391626005873 metal binding site 1 [ion binding]; metal-binding site 391626005874 dimer interface [polypeptide binding]; other site 391626005875 structural Zn2+ binding site [ion binding]; other site 391626005876 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391626005877 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391626005878 active site 391626005879 HIGH motif; other site 391626005880 dimer interface [polypeptide binding]; other site 391626005881 KMSKS motif; other site 391626005882 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391626005883 RNA binding surface [nucleotide binding]; other site 391626005884 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 391626005885 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 391626005886 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391626005887 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391626005888 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391626005889 tetramer interface [polypeptide binding]; other site 391626005890 active site 391626005891 Mg2+/Mn2+ binding site [ion binding]; other site 391626005892 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 391626005893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626005894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626005895 homodimer interface [polypeptide binding]; other site 391626005896 catalytic residue [active] 391626005897 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 391626005898 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 391626005899 DNA binding residues [nucleotide binding] 391626005900 dimer interface [polypeptide binding]; other site 391626005901 [2Fe-2S] cluster binding site [ion binding]; other site 391626005902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626005903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391626005904 active site 391626005905 metal binding site [ion binding]; metal-binding site 391626005906 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391626005907 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626005908 active site 391626005909 HIGH motif; other site 391626005910 nucleotide binding site [chemical binding]; other site 391626005911 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391626005912 KMSKS motif; other site 391626005913 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 391626005914 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 391626005915 active site 391626005916 catalytic residues [active] 391626005917 metal binding site [ion binding]; metal-binding site 391626005918 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391626005919 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391626005920 aspartate-rich region 1; other site 391626005921 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 391626005922 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391626005923 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 391626005924 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391626005925 active site 391626005926 SAM binding site [chemical binding]; other site 391626005927 homodimer interface [polypeptide binding]; other site 391626005928 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 391626005929 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 391626005930 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 391626005931 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391626005932 endonuclease III; Region: ENDO3c; smart00478 391626005933 minor groove reading motif; other site 391626005934 helix-hairpin-helix signature motif; other site 391626005935 substrate binding pocket [chemical binding]; other site 391626005936 active site 391626005937 Predicted esterase [General function prediction only]; Region: COG0400 391626005938 putative hydrolase; Provisional; Region: PRK11460 391626005939 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 391626005940 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391626005941 active site 391626005942 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391626005943 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391626005944 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391626005945 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 391626005946 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 391626005947 putative active site [active] 391626005948 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 391626005949 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 391626005950 active site 391626005951 dimer interface [polypeptide binding]; other site 391626005952 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 391626005953 dimer interface [polypeptide binding]; other site 391626005954 active site 391626005955 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391626005956 active site 391626005957 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391626005958 homotrimer interaction site [polypeptide binding]; other site 391626005959 putative active site [active] 391626005960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626005961 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626005962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626005963 Walker A/P-loop; other site 391626005964 ATP binding site [chemical binding]; other site 391626005965 ABC transporter; Region: ABC_tran; pfam00005 391626005966 Q-loop/lid; other site 391626005967 ABC transporter signature motif; other site 391626005968 Walker B; other site 391626005969 D-loop; other site 391626005970 H-loop/switch region; other site 391626005971 Putative transcription activator [Transcription]; Region: TenA; COG0819 391626005972 NMT1/THI5 like; Region: NMT1; pfam09084 391626005973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391626005974 membrane-bound complex binding site; other site 391626005975 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391626005976 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 391626005977 ATP binding site [chemical binding]; other site 391626005978 substrate interface [chemical binding]; other site 391626005979 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391626005980 active site residue [active] 391626005981 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391626005982 thiamine phosphate binding site [chemical binding]; other site 391626005983 active site 391626005984 pyrophosphate binding site [ion binding]; other site 391626005985 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391626005986 ThiS interaction site; other site 391626005987 putative active site [active] 391626005988 tetramer interface [polypeptide binding]; other site 391626005989 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391626005990 thiS-thiF/thiG interaction site; other site 391626005991 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391626005992 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391626005993 dimer interface [polypeptide binding]; other site 391626005994 substrate binding site [chemical binding]; other site 391626005995 ATP binding site [chemical binding]; other site 391626005996 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626005997 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626005998 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626005999 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391626006000 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391626006001 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391626006002 FAD binding pocket [chemical binding]; other site 391626006003 FAD binding motif [chemical binding]; other site 391626006004 phosphate binding motif [ion binding]; other site 391626006005 beta-alpha-beta structure motif; other site 391626006006 NAD binding pocket [chemical binding]; other site 391626006007 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626006008 Amidohydrolase; Region: Amidohydro_4; pfam13147 391626006009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 391626006010 active site 391626006011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626006012 Transposase; Region: HTH_Tnp_1; cl17663 391626006013 MarR family; Region: MarR_2; cl17246 391626006014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391626006015 Amino acid synthesis; Region: AA_synth; pfam06684 391626006016 Amino acid synthesis; Region: AA_synth; pfam06684 391626006017 hypothetical protein; Provisional; Region: PRK04334 391626006018 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391626006019 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626006020 catalytic loop [active] 391626006021 iron binding site [ion binding]; other site 391626006022 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626006023 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391626006024 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626006025 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626006026 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391626006027 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391626006028 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626006029 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626006030 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626006031 DctM-like transporters; Region: DctM; pfam06808 391626006032 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626006033 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391626006034 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391626006035 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391626006036 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626006037 FAD binding site [chemical binding]; other site 391626006038 substrate binding pocket [chemical binding]; other site 391626006039 catalytic base [active] 391626006040 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391626006041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626006042 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 391626006043 dimerization interface [polypeptide binding]; other site 391626006044 substrate binding pocket [chemical binding]; other site 391626006045 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626006046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626006047 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391626006048 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391626006049 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 391626006050 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 391626006051 putative dimer interface [polypeptide binding]; other site 391626006052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626006053 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 391626006054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626006055 catalytic loop [active] 391626006056 iron binding site [ion binding]; other site 391626006057 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391626006058 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626006059 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 391626006060 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391626006061 active site 391626006062 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 391626006063 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 391626006064 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391626006065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626006066 dimer interface [polypeptide binding]; other site 391626006067 phosphorylation site [posttranslational modification] 391626006068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006069 ATP binding site [chemical binding]; other site 391626006070 Mg2+ binding site [ion binding]; other site 391626006071 G-X-G motif; other site 391626006072 Response regulator receiver domain; Region: Response_reg; pfam00072 391626006073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006074 active site 391626006075 phosphorylation site [posttranslational modification] 391626006076 intermolecular recognition site; other site 391626006077 dimerization interface [polypeptide binding]; other site 391626006078 Glucokinase; Region: Glucokinase; pfam02685 391626006079 glucokinase, proteobacterial type; Region: glk; TIGR00749 391626006080 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391626006081 beta-galactosidase; Region: BGL; TIGR03356 391626006082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626006083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626006084 DNA binding site [nucleotide binding] 391626006085 domain linker motif; other site 391626006086 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 391626006087 ligand binding site [chemical binding]; other site 391626006088 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626006089 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626006090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006091 conserved gate region; other site 391626006092 dimer interface [polypeptide binding]; other site 391626006093 putative PBP binding loops; other site 391626006094 ABC-ATPase subunit interface; other site 391626006095 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 391626006096 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 391626006097 active site 391626006098 catalytic site [active] 391626006099 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 391626006100 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626006101 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626006102 Walker A/P-loop; other site 391626006103 ATP binding site [chemical binding]; other site 391626006104 Q-loop/lid; other site 391626006105 ABC transporter signature motif; other site 391626006106 Walker B; other site 391626006107 D-loop; other site 391626006108 H-loop/switch region; other site 391626006109 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 391626006110 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 391626006111 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 391626006112 Protein of unknown function (DUF805); Region: DUF805; pfam05656 391626006113 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 391626006114 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 391626006115 N- and C-terminal domain interface [polypeptide binding]; other site 391626006116 active site 391626006117 MgATP binding site [chemical binding]; other site 391626006118 catalytic site [active] 391626006119 metal binding site [ion binding]; metal-binding site 391626006120 glycerol binding site [chemical binding]; other site 391626006121 homotetramer interface [polypeptide binding]; other site 391626006122 homodimer interface [polypeptide binding]; other site 391626006123 FBP binding site [chemical binding]; other site 391626006124 protein IIAGlc interface [polypeptide binding]; other site 391626006125 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391626006126 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626006127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626006128 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626006129 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391626006130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626006131 Transposase; Region: HTH_Tnp_1; pfam01527 391626006132 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626006133 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626006134 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626006135 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391626006136 xylose isomerase; Provisional; Region: PRK05474 391626006137 xylose isomerase; Region: xylose_isom_A; TIGR02630 391626006138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626006139 DNA binding site [nucleotide binding] 391626006140 domain linker motif; other site 391626006141 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391626006142 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626006143 putative ligand binding site [chemical binding]; other site 391626006144 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391626006145 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 391626006146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626006147 putative active site [active] 391626006148 heme pocket [chemical binding]; other site 391626006149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626006150 putative active site [active] 391626006151 heme pocket [chemical binding]; other site 391626006152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391626006153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626006154 metal binding site [ion binding]; metal-binding site 391626006155 active site 391626006156 I-site; other site 391626006157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626006158 Peptidase M15; Region: Peptidase_M15_3; cl01194 391626006159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391626006160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 391626006161 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391626006162 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 391626006163 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 391626006164 trimer interface [polypeptide binding]; other site 391626006165 active site 391626006166 UDP-GlcNAc binding site [chemical binding]; other site 391626006167 lipid binding site [chemical binding]; lipid-binding site 391626006168 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 391626006169 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391626006170 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391626006171 dimer interface [polypeptide binding]; other site 391626006172 active site 391626006173 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 391626006174 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 391626006175 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 391626006176 Domain of unknown function DUF21; Region: DUF21; pfam01595 391626006177 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391626006178 Transporter associated domain; Region: CorC_HlyC; smart01091 391626006179 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391626006180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626006181 active site 391626006182 DNA binding site [nucleotide binding] 391626006183 Int/Topo IB signature motif; other site 391626006184 shikimate kinase; Provisional; Region: PRK13946 391626006185 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 391626006186 ADP binding site [chemical binding]; other site 391626006187 magnesium binding site [ion binding]; other site 391626006188 putative shikimate binding site; other site 391626006189 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391626006190 active site 391626006191 dimer interface [polypeptide binding]; other site 391626006192 metal binding site [ion binding]; metal-binding site 391626006193 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391626006194 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391626006195 dimer interface [polypeptide binding]; other site 391626006196 ssDNA binding site [nucleotide binding]; other site 391626006197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391626006198 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391626006199 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626006200 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626006201 catalytic residue [active] 391626006202 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 391626006203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626006204 Walker A/P-loop; other site 391626006205 ATP binding site [chemical binding]; other site 391626006206 Q-loop/lid; other site 391626006207 ABC transporter signature motif; other site 391626006208 Walker B; other site 391626006209 D-loop; other site 391626006210 H-loop/switch region; other site 391626006211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626006212 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626006213 Walker A/P-loop; other site 391626006214 ATP binding site [chemical binding]; other site 391626006215 Q-loop/lid; other site 391626006216 ABC transporter signature motif; other site 391626006217 Walker B; other site 391626006218 D-loop; other site 391626006219 H-loop/switch region; other site 391626006220 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626006221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626006222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626006223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006224 dimer interface [polypeptide binding]; other site 391626006225 conserved gate region; other site 391626006226 putative PBP binding loops; other site 391626006227 ABC-ATPase subunit interface; other site 391626006228 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626006229 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391626006230 Helix-turn-helix domain; Region: HTH_18; pfam12833 391626006231 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 391626006232 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 391626006233 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 391626006234 putative nucleotide binding site [chemical binding]; other site 391626006235 uridine monophosphate binding site [chemical binding]; other site 391626006236 homohexameric interface [polypeptide binding]; other site 391626006237 ribosome recycling factor; Reviewed; Region: frr; PRK00083 391626006238 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 391626006239 hinge region; other site 391626006240 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 391626006241 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 391626006242 catalytic residue [active] 391626006243 putative FPP diphosphate binding site; other site 391626006244 putative FPP binding hydrophobic cleft; other site 391626006245 dimer interface [polypeptide binding]; other site 391626006246 putative IPP diphosphate binding site; other site 391626006247 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391626006248 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 391626006249 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391626006250 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391626006251 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391626006252 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 391626006253 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391626006254 RIP metalloprotease RseP; Region: TIGR00054 391626006255 active site 391626006256 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 391626006257 protein binding site [polypeptide binding]; other site 391626006258 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 391626006259 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391626006260 putative substrate binding region [chemical binding]; other site 391626006261 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 391626006262 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391626006263 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391626006264 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391626006265 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391626006266 Surface antigen; Region: Bac_surface_Ag; pfam01103 391626006267 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 391626006268 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 391626006269 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 391626006270 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 391626006271 active site 391626006272 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 391626006273 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 391626006274 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391626006275 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391626006276 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391626006277 Virulence factor; Region: Virulence_fact; pfam13769 391626006278 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 391626006279 FAD binding site [chemical binding]; other site 391626006280 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391626006281 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 391626006282 substrate binding pocket [chemical binding]; other site 391626006283 dimer interface [polypeptide binding]; other site 391626006284 inhibitor binding site; inhibition site 391626006285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 391626006286 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 391626006287 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 391626006288 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 391626006289 Ligand Binding Site [chemical binding]; other site 391626006290 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 391626006291 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626006292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006293 active site 391626006294 phosphorylation site [posttranslational modification] 391626006295 intermolecular recognition site; other site 391626006296 dimerization interface [polypeptide binding]; other site 391626006297 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626006298 DNA binding site [nucleotide binding] 391626006299 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391626006300 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391626006301 nucleotide binding pocket [chemical binding]; other site 391626006302 K-X-D-G motif; other site 391626006303 catalytic site [active] 391626006304 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391626006305 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391626006306 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 391626006307 Dimer interface [polypeptide binding]; other site 391626006308 BRCT sequence motif; other site 391626006309 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391626006310 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391626006311 generic binding surface II; other site 391626006312 ssDNA binding site; other site 391626006313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626006314 ATP binding site [chemical binding]; other site 391626006315 putative Mg++ binding site [ion binding]; other site 391626006316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626006317 nucleotide binding region [chemical binding]; other site 391626006318 ATP-binding site [chemical binding]; other site 391626006319 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 391626006320 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391626006321 trimerization site [polypeptide binding]; other site 391626006322 active site 391626006323 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 391626006324 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 391626006325 active site 391626006326 HIGH motif; other site 391626006327 nucleotide binding site [chemical binding]; other site 391626006328 active site 391626006329 KMSKS motif; other site 391626006330 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391626006331 Glucose inhibited division protein A; Region: GIDA; pfam01134 391626006332 DNA gyrase subunit A; Validated; Region: PRK05560 391626006333 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391626006334 CAP-like domain; other site 391626006335 active site 391626006336 primary dimer interface [polypeptide binding]; other site 391626006337 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626006338 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626006339 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626006340 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626006341 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391626006342 ornithine cyclodeaminase; Validated; Region: PRK07589 391626006343 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391626006344 Arginase family; Region: Arginase; cd09989 391626006345 agmatinase; Region: agmatinase; TIGR01230 391626006346 active site 391626006347 Mn binding site [ion binding]; other site 391626006348 oligomer interface [polypeptide binding]; other site 391626006349 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391626006350 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391626006351 AsnC family; Region: AsnC_trans_reg; pfam01037 391626006352 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391626006353 Predicted membrane protein [Function unknown]; Region: COG1238 391626006354 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 391626006355 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391626006356 Ligand binding site; other site 391626006357 metal-binding site 391626006358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626006359 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626006360 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626006361 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626006362 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626006363 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626006364 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626006365 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391626006366 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626006367 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 391626006368 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 391626006369 dimer interface [polypeptide binding]; other site 391626006370 allosteric magnesium binding site [ion binding]; other site 391626006371 active site 391626006372 aspartate-rich active site metal binding site; other site 391626006373 Schiff base residues; other site 391626006374 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391626006375 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 391626006376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626006377 ATP binding site [chemical binding]; other site 391626006378 putative Mg++ binding site [ion binding]; other site 391626006379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626006380 nucleotide binding region [chemical binding]; other site 391626006381 ATP-binding site [chemical binding]; other site 391626006382 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 391626006383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626006384 putative substrate translocation pore; other site 391626006385 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391626006386 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391626006387 catalytic residues [active] 391626006388 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391626006389 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626006390 acyl-activating enzyme (AAE) consensus motif; other site 391626006391 AMP binding site [chemical binding]; other site 391626006392 active site 391626006393 CoA binding site [chemical binding]; other site 391626006394 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 391626006395 amphipathic channel; other site 391626006396 Asn-Pro-Ala signature motifs; other site 391626006397 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391626006398 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 391626006399 active site 391626006400 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391626006401 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391626006402 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 391626006403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626006404 NAD(P) binding site [chemical binding]; other site 391626006405 active site 391626006406 Patatin-like phospholipase; Region: Patatin; pfam01734 391626006407 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 391626006408 Uncharacterized conserved protein [Function unknown]; Region: COG2928 391626006409 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 391626006410 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626006411 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 391626006412 substrate binding site [chemical binding]; other site 391626006413 ATP binding site [chemical binding]; other site 391626006414 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 391626006415 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 391626006416 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626006417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626006418 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626006419 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391626006420 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391626006421 inhibitor site; inhibition site 391626006422 active site 391626006423 dimer interface [polypeptide binding]; other site 391626006424 catalytic residue [active] 391626006425 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391626006426 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391626006427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626006428 active site 391626006429 dihydropyrimidinase; Provisional; Region: PRK13404 391626006430 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626006431 active site 391626006432 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626006433 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 391626006434 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 391626006435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391626006436 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391626006437 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391626006438 catalytic residues [active] 391626006439 catalytic nucleophile [active] 391626006440 Presynaptic Site I dimer interface [polypeptide binding]; other site 391626006441 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391626006442 Synaptic Flat tetramer interface [polypeptide binding]; other site 391626006443 Synaptic Site I dimer interface [polypeptide binding]; other site 391626006444 DNA binding site [nucleotide binding] 391626006445 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391626006446 DNA-binding interface [nucleotide binding]; DNA binding site 391626006447 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391626006448 rRNA interaction site [nucleotide binding]; other site 391626006449 S8 interaction site; other site 391626006450 putative laminin-1 binding site; other site 391626006451 elongation factor Ts; Provisional; Region: tsf; PRK09377 391626006452 UBA/TS-N domain; Region: UBA; pfam00627 391626006453 Elongation factor TS; Region: EF_TS; pfam00889 391626006454 Elongation factor TS; Region: EF_TS; pfam00889 391626006455 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391626006456 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391626006457 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391626006458 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 391626006459 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626006460 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626006461 TM-ABC transporter signature motif; other site 391626006462 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626006463 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626006464 TM-ABC transporter signature motif; other site 391626006465 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626006466 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626006467 Walker A/P-loop; other site 391626006468 ATP binding site [chemical binding]; other site 391626006469 Q-loop/lid; other site 391626006470 ABC transporter signature motif; other site 391626006471 Walker B; other site 391626006472 D-loop; other site 391626006473 H-loop/switch region; other site 391626006474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626006475 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626006476 Walker A/P-loop; other site 391626006477 ATP binding site [chemical binding]; other site 391626006478 Q-loop/lid; other site 391626006479 ABC transporter signature motif; other site 391626006480 Walker B; other site 391626006481 D-loop; other site 391626006482 H-loop/switch region; other site 391626006483 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391626006484 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391626006485 heme binding site [chemical binding]; other site 391626006486 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 391626006487 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391626006488 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626006489 putative aminotransferase; Validated; Region: PRK07480 391626006490 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391626006491 inhibitor-cofactor binding pocket; inhibition site 391626006492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626006493 catalytic residue [active] 391626006494 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 391626006495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626006496 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626006497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626006498 Walker A/P-loop; other site 391626006499 ATP binding site [chemical binding]; other site 391626006500 Q-loop/lid; other site 391626006501 ABC transporter signature motif; other site 391626006502 Walker B; other site 391626006503 D-loop; other site 391626006504 H-loop/switch region; other site 391626006505 TOBE domain; Region: TOBE_2; pfam08402 391626006506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626006507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006508 dimer interface [polypeptide binding]; other site 391626006509 conserved gate region; other site 391626006510 putative PBP binding loops; other site 391626006511 ABC-ATPase subunit interface; other site 391626006512 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626006513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006514 dimer interface [polypeptide binding]; other site 391626006515 conserved gate region; other site 391626006516 putative PBP binding loops; other site 391626006517 ABC-ATPase subunit interface; other site 391626006518 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 391626006519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006520 active site 391626006521 phosphorylation site [posttranslational modification] 391626006522 intermolecular recognition site; other site 391626006523 dimerization interface [polypeptide binding]; other site 391626006524 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626006525 DNA binding site [nucleotide binding] 391626006526 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 391626006527 PhoU domain; Region: PhoU; pfam01895 391626006528 PhoU domain; Region: PhoU; pfam01895 391626006529 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 391626006530 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 391626006531 Walker A/P-loop; other site 391626006532 ATP binding site [chemical binding]; other site 391626006533 Q-loop/lid; other site 391626006534 ABC transporter signature motif; other site 391626006535 Walker B; other site 391626006536 D-loop; other site 391626006537 H-loop/switch region; other site 391626006538 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 391626006539 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 391626006540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006541 dimer interface [polypeptide binding]; other site 391626006542 conserved gate region; other site 391626006543 putative PBP binding loops; other site 391626006544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626006545 ABC-ATPase subunit interface; other site 391626006546 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 391626006547 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 391626006548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006549 dimer interface [polypeptide binding]; other site 391626006550 conserved gate region; other site 391626006551 putative PBP binding loops; other site 391626006552 ABC-ATPase subunit interface; other site 391626006553 PBP superfamily domain; Region: PBP_like_2; pfam12849 391626006554 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391626006555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626006556 dimer interface [polypeptide binding]; other site 391626006557 phosphorylation site [posttranslational modification] 391626006558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006559 ATP binding site [chemical binding]; other site 391626006560 Mg2+ binding site [ion binding]; other site 391626006561 G-X-G motif; other site 391626006562 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391626006563 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626006564 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626006565 catalytic residue [active] 391626006566 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 391626006567 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 391626006568 trimer interface [polypeptide binding]; other site 391626006569 putative metal binding site [ion binding]; other site 391626006570 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 391626006571 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 391626006572 catalytic site [active] 391626006573 G-X2-G-X-G-K; other site 391626006574 hypothetical protein; Provisional; Region: PRK11820 391626006575 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 391626006576 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 391626006577 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391626006578 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626006579 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391626006580 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626006581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006582 ABC-ATPase subunit interface; other site 391626006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006584 dimer interface [polypeptide binding]; other site 391626006585 conserved gate region; other site 391626006586 putative PBP binding loops; other site 391626006587 ABC-ATPase subunit interface; other site 391626006588 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626006589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626006590 Walker A/P-loop; other site 391626006591 ATP binding site [chemical binding]; other site 391626006592 Q-loop/lid; other site 391626006593 ABC transporter signature motif; other site 391626006594 Walker B; other site 391626006595 D-loop; other site 391626006596 H-loop/switch region; other site 391626006597 TOBE domain; Region: TOBE_2; pfam08402 391626006598 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626006599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626006600 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391626006601 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391626006602 putative active site [active] 391626006603 metal binding site [ion binding]; metal-binding site 391626006604 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391626006605 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 391626006606 NAD(P) binding site [chemical binding]; other site 391626006607 catalytic residues [active] 391626006608 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391626006609 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391626006610 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391626006611 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626006612 DctM-like transporters; Region: DctM; pfam06808 391626006613 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626006614 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391626006615 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391626006616 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391626006617 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391626006618 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391626006619 putative active site [active] 391626006620 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626006621 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626006622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626006623 PAS domain; Region: PAS_5; pfam07310 391626006624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 391626006625 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391626006626 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391626006627 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391626006628 conserved cys residue [active] 391626006629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391626006630 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391626006631 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391626006632 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626006633 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391626006634 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391626006635 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391626006636 active site 391626006637 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 391626006638 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 391626006639 HflX GTPase family; Region: HflX; cd01878 391626006640 G1 box; other site 391626006641 GTP/Mg2+ binding site [chemical binding]; other site 391626006642 Switch I region; other site 391626006643 G2 box; other site 391626006644 G3 box; other site 391626006645 Switch II region; other site 391626006646 G4 box; other site 391626006647 G5 box; other site 391626006648 bacterial Hfq-like; Region: Hfq; cd01716 391626006649 hexamer interface [polypeptide binding]; other site 391626006650 Sm1 motif; other site 391626006651 RNA binding site [nucleotide binding]; other site 391626006652 Sm2 motif; other site 391626006653 Cation transport protein; Region: TrkH; cl17365 391626006654 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391626006655 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 391626006656 TrkA-N domain; Region: TrkA_N; pfam02254 391626006657 TrkA-C domain; Region: TrkA_C; pfam02080 391626006658 TrkA-N domain; Region: TrkA_N; pfam02254 391626006659 TrkA-C domain; Region: TrkA_C; pfam02080 391626006660 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391626006661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006662 active site 391626006663 phosphorylation site [posttranslational modification] 391626006664 intermolecular recognition site; other site 391626006665 dimerization interface [polypeptide binding]; other site 391626006666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626006667 Walker A motif; other site 391626006668 ATP binding site [chemical binding]; other site 391626006669 Walker B motif; other site 391626006670 arginine finger; other site 391626006671 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391626006672 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 391626006673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391626006674 dimerization interface [polypeptide binding]; other site 391626006675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626006676 dimer interface [polypeptide binding]; other site 391626006677 phosphorylation site [posttranslational modification] 391626006678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006679 ATP binding site [chemical binding]; other site 391626006680 Mg2+ binding site [ion binding]; other site 391626006681 G-X-G motif; other site 391626006682 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 391626006683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006684 active site 391626006685 phosphorylation site [posttranslational modification] 391626006686 intermolecular recognition site; other site 391626006687 dimerization interface [polypeptide binding]; other site 391626006688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626006689 Walker A motif; other site 391626006690 ATP binding site [chemical binding]; other site 391626006691 Walker B motif; other site 391626006692 arginine finger; other site 391626006693 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391626006694 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391626006695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626006696 dimer interface [polypeptide binding]; other site 391626006697 phosphorylation site [posttranslational modification] 391626006698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006699 ATP binding site [chemical binding]; other site 391626006700 Mg2+ binding site [ion binding]; other site 391626006701 G-X-G motif; other site 391626006702 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391626006703 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 391626006704 FMN binding site [chemical binding]; other site 391626006705 active site 391626006706 catalytic residues [active] 391626006707 substrate binding site [chemical binding]; other site 391626006708 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 391626006709 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391626006710 substrate binding site; other site 391626006711 dimer interface; other site 391626006712 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 391626006713 homotrimer interaction site [polypeptide binding]; other site 391626006714 zinc binding site [ion binding]; other site 391626006715 CDP-binding sites; other site 391626006716 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 391626006717 tetramer interfaces [polypeptide binding]; other site 391626006718 binuclear metal-binding site [ion binding]; other site 391626006719 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 391626006720 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 391626006721 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391626006722 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 391626006723 putative coenzyme Q binding site [chemical binding]; other site 391626006724 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 391626006725 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626006726 active site 391626006727 Cytochrome C' Region: Cytochrom_C_2; cl01610 391626006728 lipoyl synthase; Provisional; Region: PRK05481 391626006729 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626006730 FeS/SAM binding site; other site 391626006731 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626006732 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626006733 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 391626006734 GMP synthase; Reviewed; Region: guaA; PRK00074 391626006735 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391626006736 AMP/PPi binding site [chemical binding]; other site 391626006737 candidate oxyanion hole; other site 391626006738 catalytic triad [active] 391626006739 potential glutamine specificity residues [chemical binding]; other site 391626006740 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391626006741 ATP Binding subdomain [chemical binding]; other site 391626006742 Ligand Binding sites [chemical binding]; other site 391626006743 Dimerization subdomain; other site 391626006744 Uncharacterized conserved protein [Function unknown]; Region: COG1434 391626006745 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 391626006746 putative active site [active] 391626006747 EamA-like transporter family; Region: EamA; pfam00892 391626006748 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391626006749 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 391626006750 Homoserine O-succinyltransferase; Region: HTS; pfam04204 391626006751 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 391626006752 proposed active site lysine [active] 391626006753 conserved cys residue [active] 391626006754 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391626006755 PGAP1-like protein; Region: PGAP1; pfam07819 391626006756 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391626006757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626006758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626006759 WHG domain; Region: WHG; pfam13305 391626006760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626006761 Integrase core domain; Region: rve_3; pfam13683 391626006762 Transposase; Region: HTH_Tnp_1; pfam01527 391626006763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626006764 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626006765 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626006766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626006767 Transposase; Region: HTH_Tnp_1; pfam01527 391626006768 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626006769 HAMP domain; Region: HAMP; pfam00672 391626006770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006771 ATP binding site [chemical binding]; other site 391626006772 Mg2+ binding site [ion binding]; other site 391626006773 G-X-G motif; other site 391626006774 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391626006775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626006776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626006777 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 391626006778 DNA polymerase IV; Reviewed; Region: PRK03103 391626006779 Y-family of DNA polymerases; Region: PolY; cd00424 391626006780 active site 391626006781 DNA binding site [nucleotide binding] 391626006782 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391626006783 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 391626006784 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391626006785 NADP binding site [chemical binding]; other site 391626006786 dimer interface [polypeptide binding]; other site 391626006787 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 391626006788 nudix motif; other site 391626006789 LysE type translocator; Region: LysE; cl00565 391626006790 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 391626006791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626006792 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391626006793 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626006794 active site 391626006795 DNA binding site [nucleotide binding] 391626006796 Int/Topo IB signature motif; other site 391626006797 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391626006798 Putative transposase; Region: Y2_Tnp; pfam04986 391626006799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391626006800 MarR family; Region: MarR_2; cl17246 391626006801 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 391626006802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626006803 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391626006804 NAD(P) binding site [chemical binding]; other site 391626006805 active site 391626006806 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 391626006807 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626006808 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626006809 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626006810 Winged helix-turn helix; Region: HTH_29; pfam13551 391626006811 Homeodomain-like domain; Region: HTH_32; pfam13565 391626006812 Integrase core domain; Region: rve; pfam00665 391626006813 Integrase core domain; Region: rve; pfam00665 391626006814 Integrase core domain; Region: rve_3; pfam13683 391626006815 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 391626006816 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 391626006817 N- and C-terminal domain interface [polypeptide binding]; other site 391626006818 active site 391626006819 MgATP binding site [chemical binding]; other site 391626006820 catalytic site [active] 391626006821 metal binding site [ion binding]; metal-binding site 391626006822 carbohydrate binding site [chemical binding]; other site 391626006823 putative homodimer interface [polypeptide binding]; other site 391626006824 classical (c) SDRs; Region: SDR_c; cd05233 391626006825 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 391626006826 NAD(P) binding site [chemical binding]; other site 391626006827 active site 391626006828 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391626006829 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626006830 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626006831 TM-ABC transporter signature motif; other site 391626006832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626006833 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 391626006834 Walker A/P-loop; other site 391626006835 ATP binding site [chemical binding]; other site 391626006836 Q-loop/lid; other site 391626006837 ABC transporter signature motif; other site 391626006838 Walker B; other site 391626006839 D-loop; other site 391626006840 H-loop/switch region; other site 391626006841 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391626006842 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391626006843 putative ligand binding site [chemical binding]; other site 391626006844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626006845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626006846 DNA binding site [nucleotide binding] 391626006847 domain linker motif; other site 391626006848 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391626006849 Homeodomain-like domain; Region: HTH_32; pfam13565 391626006850 Integrase core domain; Region: rve_3; pfam13683 391626006851 Integrase core domain; Region: rve_3; pfam13683 391626006852 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391626006853 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391626006854 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391626006855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626006856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626006857 active site 391626006858 phosphorylation site [posttranslational modification] 391626006859 intermolecular recognition site; other site 391626006860 dimerization interface [polypeptide binding]; other site 391626006861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626006862 DNA binding site [nucleotide binding] 391626006863 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 391626006864 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626006865 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391626006866 dimer interface [polypeptide binding]; other site 391626006867 phosphorylation site [posttranslational modification] 391626006868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626006869 ATP binding site [chemical binding]; other site 391626006870 Mg2+ binding site [ion binding]; other site 391626006871 G-X-G motif; other site 391626006872 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391626006873 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391626006874 Integrase core domain; Region: rve; pfam00665 391626006875 Integrase core domain; Region: rve_3; pfam13683 391626006876 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626006877 Winged helix-turn helix; Region: HTH_29; pfam13551 391626006878 Homeodomain-like domain; Region: HTH_32; pfam13565 391626006879 Integrase core domain; Region: rve; pfam00665 391626006880 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626006881 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 391626006882 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626006883 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626006884 substrate binding pocket [chemical binding]; other site 391626006885 membrane-bound complex binding site; other site 391626006886 hinge residues; other site 391626006887 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391626006888 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391626006889 Walker A/P-loop; other site 391626006890 ATP binding site [chemical binding]; other site 391626006891 Q-loop/lid; other site 391626006892 ABC transporter signature motif; other site 391626006893 Walker B; other site 391626006894 D-loop; other site 391626006895 H-loop/switch region; other site 391626006896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626006897 dimer interface [polypeptide binding]; other site 391626006898 conserved gate region; other site 391626006899 putative PBP binding loops; other site 391626006900 ABC-ATPase subunit interface; other site 391626006901 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391626006902 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 391626006903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626006904 Transposase; Region: HTH_Tnp_1; cl17663 391626006905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626006906 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626006907 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626006908 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626006909 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626006910 T5orf172 domain; Region: T5orf172; pfam10544 391626006911 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 391626006912 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391626006913 23S rRNA interface [nucleotide binding]; other site 391626006914 L3 interface [polypeptide binding]; other site 391626006915 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391626006916 CoenzymeA binding site [chemical binding]; other site 391626006917 subunit interaction site [polypeptide binding]; other site 391626006918 PHB binding site; other site 391626006919 enoyl-CoA hydratase; Validated; Region: PRK08139 391626006920 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626006921 substrate binding site [chemical binding]; other site 391626006922 oxyanion hole (OAH) forming residues; other site 391626006923 trimer interface [polypeptide binding]; other site 391626006924 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 391626006925 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 391626006926 active site 391626006927 Zn binding site [ion binding]; other site 391626006928 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 391626006929 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 391626006930 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 391626006931 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 391626006932 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391626006933 thiamine phosphate binding site [chemical binding]; other site 391626006934 active site 391626006935 pyrophosphate binding site [ion binding]; other site 391626006936 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391626006937 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391626006938 putative acyl-acceptor binding pocket; other site 391626006939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 391626006940 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 391626006941 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391626006942 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391626006943 putative catalytic cysteine [active] 391626006944 gamma-glutamyl kinase; Provisional; Region: PRK05429 391626006945 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391626006946 nucleotide binding site [chemical binding]; other site 391626006947 homotetrameric interface [polypeptide binding]; other site 391626006948 putative phosphate binding site [ion binding]; other site 391626006949 putative allosteric binding site; other site 391626006950 PUA domain; Region: PUA; pfam01472 391626006951 GTPase CgtA; Reviewed; Region: obgE; PRK12299 391626006952 GTP1/OBG; Region: GTP1_OBG; pfam01018 391626006953 Obg GTPase; Region: Obg; cd01898 391626006954 G1 box; other site 391626006955 GTP/Mg2+ binding site [chemical binding]; other site 391626006956 Switch I region; other site 391626006957 G2 box; other site 391626006958 G3 box; other site 391626006959 Switch II region; other site 391626006960 G4 box; other site 391626006961 G5 box; other site 391626006962 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626006963 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626006964 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391626006965 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 391626006966 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 391626006967 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 391626006968 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391626006969 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 391626006970 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 391626006971 Protein of unknown function DUF45; Region: DUF45; pfam01863 391626006972 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 391626006973 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391626006974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626006975 ATP binding site [chemical binding]; other site 391626006976 putative Mg++ binding site [ion binding]; other site 391626006977 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391626006978 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391626006979 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391626006980 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 391626006981 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391626006982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391626006983 D5 N terminal like; Region: D5_N; pfam08706 391626006984 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 391626006985 integrase; Provisional; Region: PRK09692 391626006986 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391626006987 active site 391626006988 Int/Topo IB signature motif; other site 391626006989 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626006990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626006991 DNA binding site [nucleotide binding] 391626006992 active site 391626006993 Int/Topo IB signature motif; other site 391626006994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626006995 Integrase core domain; Region: rve_3; pfam13683 391626006996 Dehydratase family; Region: ILVD_EDD; cl00340 391626006997 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626006998 Winged helix-turn helix; Region: HTH_29; pfam13551 391626006999 Homeodomain-like domain; Region: HTH_32; pfam13565 391626007000 Integrase core domain; Region: rve; pfam00665 391626007001 Integrase core domain; Region: rve; pfam00665 391626007002 Integrase core domain; Region: rve_3; pfam13683 391626007003 Transposase; Region: HTH_Tnp_1; pfam01527 391626007004 HTH-like domain; Region: HTH_21; pfam13276 391626007005 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626007006 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626007007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626007008 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626007009 dimerization interface [polypeptide binding]; other site 391626007010 Predicted permease [General function prediction only]; Region: COG3329 391626007011 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391626007012 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 391626007013 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391626007014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626007015 dimerization interface [polypeptide binding]; other site 391626007016 putative DNA binding site [nucleotide binding]; other site 391626007017 putative Zn2+ binding site [ion binding]; other site 391626007018 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391626007019 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391626007020 active site 391626007021 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 391626007022 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391626007023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626007024 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 391626007025 active site 391626007026 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 391626007027 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391626007028 active site 391626007029 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 391626007030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626007031 Walker A/P-loop; other site 391626007032 ATP binding site [chemical binding]; other site 391626007033 Q-loop/lid; other site 391626007034 ABC transporter signature motif; other site 391626007035 Walker B; other site 391626007036 D-loop; other site 391626007037 H-loop/switch region; other site 391626007038 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 391626007039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626007040 Walker A/P-loop; other site 391626007041 ATP binding site [chemical binding]; other site 391626007042 Q-loop/lid; other site 391626007043 ABC transporter signature motif; other site 391626007044 Walker B; other site 391626007045 D-loop; other site 391626007046 H-loop/switch region; other site 391626007047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626007048 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 391626007049 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 391626007050 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 391626007051 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 391626007052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626007053 DNA-binding site [nucleotide binding]; DNA binding site 391626007054 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 391626007055 UTRA domain; Region: UTRA; pfam07702 391626007056 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 391626007057 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391626007058 trimer interface [polypeptide binding]; other site 391626007059 active site 391626007060 substrate binding site [chemical binding]; other site 391626007061 CoA binding site [chemical binding]; other site 391626007062 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391626007063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626007064 dimer interface [polypeptide binding]; other site 391626007065 conserved gate region; other site 391626007066 ABC-ATPase subunit interface; other site 391626007067 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391626007068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626007069 dimer interface [polypeptide binding]; other site 391626007070 conserved gate region; other site 391626007071 putative PBP binding loops; other site 391626007072 ABC-ATPase subunit interface; other site 391626007073 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391626007074 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 391626007075 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 391626007076 Walker A/P-loop; other site 391626007077 ATP binding site [chemical binding]; other site 391626007078 Q-loop/lid; other site 391626007079 ABC transporter signature motif; other site 391626007080 Walker B; other site 391626007081 D-loop; other site 391626007082 H-loop/switch region; other site 391626007083 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391626007084 OsmC-like protein; Region: OsmC; pfam02566 391626007085 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626007086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626007087 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391626007088 dimerization interface [polypeptide binding]; other site 391626007089 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626007090 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391626007091 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391626007092 active site 391626007093 DNA binding site [nucleotide binding] 391626007094 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391626007095 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 391626007096 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 391626007097 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 391626007098 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391626007099 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 391626007100 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391626007101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 391626007102 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 391626007103 Uncharacterized conserved protein [Function unknown]; Region: COG2308 391626007104 TfoX C-terminal domain; Region: TfoX_C; pfam04994 391626007105 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391626007106 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626007107 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626007108 catalytic residue [active] 391626007109 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391626007110 active site 391626007111 multimer interface [polypeptide binding]; other site 391626007112 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391626007113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626007114 Walker A/P-loop; other site 391626007115 ATP binding site [chemical binding]; other site 391626007116 Q-loop/lid; other site 391626007117 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626007118 ABC transporter; Region: ABC_tran_2; pfam12848 391626007119 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626007120 MarC family integral membrane protein; Region: MarC; cl00919 391626007121 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 391626007122 catalytic motif [active] 391626007123 Catalytic residue [active] 391626007124 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 391626007125 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391626007126 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391626007127 interface (dimer of trimers) [polypeptide binding]; other site 391626007128 Substrate-binding/catalytic site; other site 391626007129 Zn-binding sites [ion binding]; other site 391626007130 Predicted permeases [General function prediction only]; Region: COG0795 391626007131 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391626007132 Predicted permeases [General function prediction only]; Region: COG0795 391626007133 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391626007134 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 391626007135 Organic solvent tolerance protein; Region: OstA_C; pfam04453 391626007136 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 391626007137 SurA N-terminal domain; Region: SurA_N; pfam09312 391626007138 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391626007139 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 391626007140 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391626007141 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 391626007142 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 391626007143 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 391626007144 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 391626007145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626007146 S-adenosylmethionine binding site [chemical binding]; other site 391626007147 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391626007148 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391626007149 RF-1 domain; Region: RF-1; pfam00472 391626007150 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 391626007151 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391626007152 agmatinase; Region: agmatinase; TIGR01230 391626007153 oligomer interface [polypeptide binding]; other site 391626007154 putative active site [active] 391626007155 Mn binding site [ion binding]; other site 391626007156 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391626007157 agmatinase; Region: agmatinase; TIGR01230 391626007158 oligomer interface [polypeptide binding]; other site 391626007159 putative active site [active] 391626007160 Mn binding site [ion binding]; other site 391626007161 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391626007162 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391626007163 metal binding site [ion binding]; metal-binding site 391626007164 putative dimer interface [polypeptide binding]; other site 391626007165 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 391626007166 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 391626007167 homodimer interface [polypeptide binding]; other site 391626007168 metal binding site [ion binding]; metal-binding site 391626007169 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 391626007170 homodimer interface [polypeptide binding]; other site 391626007171 active site 391626007172 putative chemical substrate binding site [chemical binding]; other site 391626007173 metal binding site [ion binding]; metal-binding site 391626007174 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626007175 ABC transporter ATPase component; Reviewed; Region: PRK11147 391626007176 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626007177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391626007178 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 391626007179 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 391626007180 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 391626007181 putative phosphate acyltransferase; Provisional; Region: PRK05331 391626007182 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391626007183 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391626007184 dimer interface [polypeptide binding]; other site 391626007185 active site 391626007186 CoA binding pocket [chemical binding]; other site 391626007187 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391626007188 IHF dimer interface [polypeptide binding]; other site 391626007189 IHF - DNA interface [nucleotide binding]; other site 391626007190 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 391626007191 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391626007192 DNA binding residues [nucleotide binding] 391626007193 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 391626007194 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391626007195 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391626007196 trimer interface [polypeptide binding]; other site 391626007197 active site 391626007198 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 391626007199 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 391626007200 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391626007201 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391626007202 Sporulation related domain; Region: SPOR; pfam05036 391626007203 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 391626007204 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 391626007205 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391626007206 active site 391626007207 HIGH motif; other site 391626007208 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626007209 KMSK motif region; other site 391626007210 tRNA binding surface [nucleotide binding]; other site 391626007211 DALR anticodon binding domain; Region: DALR_1; smart00836 391626007212 anticodon binding site; other site 391626007213 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 391626007214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391626007215 Zn2+ binding site [ion binding]; other site 391626007216 Mg2+ binding site [ion binding]; other site 391626007217 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 391626007218 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391626007219 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391626007220 putative catalytic site [active] 391626007221 putative phosphate binding site [ion binding]; other site 391626007222 active site 391626007223 metal binding site A [ion binding]; metal-binding site 391626007224 DNA binding site [nucleotide binding] 391626007225 putative AP binding site [nucleotide binding]; other site 391626007226 putative metal binding site B [ion binding]; other site 391626007227 salicylate hydroxylase; Provisional; Region: PRK08163 391626007228 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391626007229 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 391626007230 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391626007231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007232 Walker A motif; other site 391626007233 ATP binding site [chemical binding]; other site 391626007234 Walker B motif; other site 391626007235 arginine finger; other site 391626007236 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391626007237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 391626007238 short chain dehydrogenase; Provisional; Region: PRK07060 391626007239 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391626007240 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391626007241 Peptidase family M48; Region: Peptidase_M48; cl12018 391626007242 PIN domain; Region: PIN_3; pfam13470 391626007243 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 391626007244 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 391626007245 putative RNA binding site [nucleotide binding]; other site 391626007246 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391626007247 phosphogluconate dehydratase; Validated; Region: PRK09054 391626007248 6-phosphogluconate dehydratase; Region: edd; TIGR01196 391626007249 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 391626007250 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391626007251 active site 391626007252 intersubunit interface [polypeptide binding]; other site 391626007253 catalytic residue [active] 391626007254 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 391626007255 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391626007256 metal binding triad; other site 391626007257 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391626007258 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391626007259 metal binding triad; other site 391626007260 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 391626007261 putative deacylase active site [active] 391626007262 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391626007263 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391626007264 RDD family; Region: RDD; pfam06271 391626007265 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 391626007266 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 391626007267 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 391626007268 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626007269 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626007270 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391626007271 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 391626007272 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626007273 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 391626007274 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626007275 PYR/PP interface [polypeptide binding]; other site 391626007276 dimer interface [polypeptide binding]; other site 391626007277 TPP binding site [chemical binding]; other site 391626007278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391626007279 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391626007280 TPP-binding site [chemical binding]; other site 391626007281 dimer interface [polypeptide binding]; other site 391626007282 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391626007283 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391626007284 putative valine binding site [chemical binding]; other site 391626007285 dimer interface [polypeptide binding]; other site 391626007286 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391626007287 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391626007288 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391626007289 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391626007290 [2Fe-2S] cluster binding site [ion binding]; other site 391626007291 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391626007292 alpha subunit interface [polypeptide binding]; other site 391626007293 active site 391626007294 substrate binding site [chemical binding]; other site 391626007295 Fe binding site [ion binding]; other site 391626007296 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 391626007297 active site 391626007298 tetramer interface [polypeptide binding]; other site 391626007299 FOG: CBS domain [General function prediction only]; Region: COG0517 391626007300 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391626007301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626007302 hypothetical protein; Validated; Region: PRK00029 391626007303 Uncharacterized conserved protein [Function unknown]; Region: COG0397 391626007304 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 391626007305 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391626007306 active site 391626007307 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391626007308 active site 391626007309 Phosphoglycerate kinase; Region: PGK; pfam00162 391626007310 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 391626007311 substrate binding site [chemical binding]; other site 391626007312 hinge regions; other site 391626007313 ADP binding site [chemical binding]; other site 391626007314 catalytic site [active] 391626007315 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 391626007316 catalytic residue [active] 391626007317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626007318 Coenzyme A binding pocket [chemical binding]; other site 391626007319 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391626007320 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391626007321 tetramer interface [polypeptide binding]; other site 391626007322 TPP-binding site [chemical binding]; other site 391626007323 heterodimer interface [polypeptide binding]; other site 391626007324 phosphorylation loop region [posttranslational modification] 391626007325 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 391626007326 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626007327 E3 interaction surface; other site 391626007328 lipoyl attachment site [posttranslational modification]; other site 391626007329 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391626007330 alpha subunit interface [polypeptide binding]; other site 391626007331 TPP binding site [chemical binding]; other site 391626007332 heterodimer interface [polypeptide binding]; other site 391626007333 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391626007334 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 391626007335 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626007336 E3 interaction surface; other site 391626007337 lipoyl attachment site [posttranslational modification]; other site 391626007338 e3 binding domain; Region: E3_binding; pfam02817 391626007339 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391626007340 serine acetyltransferase; Provisional; Region: cysE; PRK11132 391626007341 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 391626007342 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 391626007343 trimer interface [polypeptide binding]; other site 391626007344 active site 391626007345 substrate binding site [chemical binding]; other site 391626007346 CoA binding site [chemical binding]; other site 391626007347 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 391626007348 Putative phage tail protein; Region: Phage-tail_3; pfam13550 391626007349 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391626007350 NlpC/P60 family; Region: NLPC_P60; cl17555 391626007351 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 391626007352 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 391626007353 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 391626007354 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 391626007355 Phage-related minor tail protein [Function unknown]; Region: COG5281 391626007356 phage conserved hypothetical protein; Region: phage_TIGR02216 391626007357 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 391626007358 Phage major tail protein 2; Region: Phage_tail_2; cl11463 391626007359 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 391626007360 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 391626007361 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 391626007362 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391626007363 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391626007364 oligomerization interface [polypeptide binding]; other site 391626007365 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391626007366 Phage capsid family; Region: Phage_capsid; pfam05065 391626007367 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 391626007368 Phage-related protein [Function unknown]; Region: COG4695 391626007369 Phage portal protein; Region: Phage_portal; pfam04860 391626007370 Uncharacterized conserved protein [Function unknown]; Region: COG5323 391626007371 YceG-like family; Region: YceG; pfam02618 391626007372 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 391626007373 dimerization interface [polypeptide binding]; other site 391626007374 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 391626007375 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391626007376 dimer interface [polypeptide binding]; other site 391626007377 active site 391626007378 acyl carrier protein; Provisional; Region: acpP; PRK00982 391626007379 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391626007380 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391626007381 NAD(P) binding site [chemical binding]; other site 391626007382 homotetramer interface [polypeptide binding]; other site 391626007383 homodimer interface [polypeptide binding]; other site 391626007384 active site 391626007385 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391626007386 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391626007387 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 391626007388 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 391626007389 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391626007390 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391626007391 trigger factor; Provisional; Region: tig; PRK01490 391626007392 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391626007393 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391626007394 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626007395 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626007396 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 391626007397 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 391626007398 dimerization interface [polypeptide binding]; other site 391626007399 ATP binding site [chemical binding]; other site 391626007400 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 391626007401 dimerization interface [polypeptide binding]; other site 391626007402 ATP binding site [chemical binding]; other site 391626007403 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391626007404 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 391626007405 putative GSH binding site [chemical binding]; other site 391626007406 catalytic residues [active] 391626007407 Cell division protein ZapA; Region: ZapA; pfam05164 391626007408 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 391626007409 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391626007410 TPP-binding site [chemical binding]; other site 391626007411 dimer interface [polypeptide binding]; other site 391626007412 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391626007413 PYR/PP interface [polypeptide binding]; other site 391626007414 dimer interface [polypeptide binding]; other site 391626007415 TPP binding site [chemical binding]; other site 391626007416 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391626007417 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 391626007418 Protein of unknown function (DUF808); Region: DUF808; cl01002 391626007419 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391626007420 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391626007421 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391626007422 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391626007423 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391626007424 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391626007425 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 391626007426 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391626007427 active site 391626007428 (T/H)XGH motif; other site 391626007429 FOG: CBS domain [General function prediction only]; Region: COG0517 391626007430 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391626007431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626007432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626007433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391626007434 dimerization interface [polypeptide binding]; other site 391626007435 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391626007436 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 391626007437 tetrameric interface [polypeptide binding]; other site 391626007438 NAD binding site [chemical binding]; other site 391626007439 catalytic residues [active] 391626007440 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 391626007441 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 391626007442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391626007443 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391626007444 carboxylate-amine ligase; Provisional; Region: PRK13515 391626007445 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 391626007446 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626007447 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626007448 active site 391626007449 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 391626007450 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626007451 substrate binding site [chemical binding]; other site 391626007452 oxyanion hole (OAH) forming residues; other site 391626007453 trimer interface [polypeptide binding]; other site 391626007454 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 391626007455 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626007456 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391626007457 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391626007458 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391626007459 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391626007460 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 391626007461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626007462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626007463 putative substrate translocation pore; other site 391626007464 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391626007465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626007466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626007467 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626007468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391626007469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626007470 I-site; other site 391626007471 active site 391626007472 metal binding site [ion binding]; metal-binding site 391626007473 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 391626007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626007475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626007476 putative substrate translocation pore; other site 391626007477 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 391626007478 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 391626007479 Protein of unknown function; Region: DUF3971; pfam13116 391626007480 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391626007481 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391626007482 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 391626007483 catalytic triad [active] 391626007484 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391626007485 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 391626007486 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391626007487 Peptidase family M23; Region: Peptidase_M23; pfam01551 391626007488 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391626007489 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 391626007490 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391626007491 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391626007492 RF-1 domain; Region: RF-1; pfam00472 391626007493 Transglycosylase; Region: Transgly; pfam00912 391626007494 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391626007495 AMIN domain; Region: AMIN; pfam11741 391626007496 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 391626007497 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391626007498 active site 391626007499 metal binding site [ion binding]; metal-binding site 391626007500 aspartate aminotransferase; Provisional; Region: PRK05764 391626007501 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626007502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626007503 homodimer interface [polypeptide binding]; other site 391626007504 catalytic residue [active] 391626007505 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 391626007506 Peptidase family M48; Region: Peptidase_M48; cl12018 391626007507 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391626007508 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 391626007509 catalytic residues [active] 391626007510 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391626007511 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391626007512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626007513 non-specific DNA binding site [nucleotide binding]; other site 391626007514 salt bridge; other site 391626007515 sequence-specific DNA binding site [nucleotide binding]; other site 391626007516 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 391626007517 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391626007518 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391626007519 substrate-cofactor binding pocket; other site 391626007520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626007521 catalytic residue [active] 391626007522 hypothetical protein; Validated; Region: PRK09104 391626007523 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 391626007524 metal binding site [ion binding]; metal-binding site 391626007525 putative dimer interface [polypeptide binding]; other site 391626007526 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 391626007527 active site triad [active] 391626007528 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391626007529 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 391626007530 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391626007531 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391626007532 ATP binding site [chemical binding]; other site 391626007533 Mg++ binding site [ion binding]; other site 391626007534 motif III; other site 391626007535 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626007536 nucleotide binding region [chemical binding]; other site 391626007537 ATP-binding site [chemical binding]; other site 391626007538 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 391626007539 RNA binding site [nucleotide binding]; other site 391626007540 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626007541 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 391626007542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626007543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626007544 WHG domain; Region: WHG; pfam13305 391626007545 YKOF-related Family; Region: Ykof; pfam07615 391626007546 YKOF-related Family; Region: Ykof; pfam07615 391626007547 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626007548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626007549 dimer interface [polypeptide binding]; other site 391626007550 conserved gate region; other site 391626007551 putative PBP binding loops; other site 391626007552 ABC-ATPase subunit interface; other site 391626007553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391626007554 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626007555 Walker A/P-loop; other site 391626007556 ATP binding site [chemical binding]; other site 391626007557 Q-loop/lid; other site 391626007558 ABC transporter signature motif; other site 391626007559 Walker B; other site 391626007560 D-loop; other site 391626007561 H-loop/switch region; other site 391626007562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391626007563 NMT1/THI5 like; Region: NMT1; pfam09084 391626007564 Transposase; Region: HTH_Tnp_1; pfam01527 391626007565 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007566 HTH-like domain; Region: HTH_21; pfam13276 391626007567 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391626007568 Maf-like protein; Region: Maf; pfam02545 391626007569 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391626007570 active site 391626007571 dimer interface [polypeptide binding]; other site 391626007572 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391626007573 rRNA binding site [nucleotide binding]; other site 391626007574 predicted 30S ribosome binding site; other site 391626007575 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391626007576 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391626007577 active site 391626007578 hypothetical protein; Provisional; Region: PRK02853 391626007579 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391626007580 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391626007581 NAD binding site [chemical binding]; other site 391626007582 dimerization interface [polypeptide binding]; other site 391626007583 product binding site; other site 391626007584 substrate binding site [chemical binding]; other site 391626007585 zinc binding site [ion binding]; other site 391626007586 catalytic residues [active] 391626007587 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 391626007588 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391626007589 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391626007590 hinge; other site 391626007591 active site 391626007592 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 391626007593 catalytic residues [active] 391626007594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007595 Transposase; Region: HTH_Tnp_1; cl17663 391626007596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626007597 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626007598 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626007599 Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608 391626007600 metal-binding site [ion binding] 391626007601 Transposase; Region: HTH_Tnp_1; pfam01527 391626007602 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007603 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 391626007604 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626007605 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626007606 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 391626007607 transposase/IS protein; Provisional; Region: PRK09183 391626007608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007609 Walker A motif; other site 391626007610 ATP binding site [chemical binding]; other site 391626007611 Walker B motif; other site 391626007612 arginine finger; other site 391626007613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626007614 Integrase core domain; Region: rve; pfam00665 391626007615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626007616 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626007617 active site 391626007618 DNA binding site [nucleotide binding] 391626007619 Int/Topo IB signature motif; other site 391626007620 Transposase; Region: HTH_Tnp_1; cl17663 391626007621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007622 putative transposase OrfB; Reviewed; Region: PHA02517 391626007623 Integrase core domain; Region: rve; pfam00665 391626007624 Integrase core domain; Region: rve_3; pfam13683 391626007625 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626007626 Integrase core domain; Region: rve_3; pfam13683 391626007627 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391626007628 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 391626007629 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 391626007630 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 391626007631 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 391626007632 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 391626007633 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 391626007634 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 391626007635 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 391626007636 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391626007637 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 391626007638 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391626007639 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 391626007640 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626007641 Walker A motif; other site 391626007642 ATP binding site [chemical binding]; other site 391626007643 Walker B motif; other site 391626007644 Flagellar assembly protein FliH; Region: FliH; pfam02108 391626007645 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391626007646 MgtE intracellular N domain; Region: MgtE_N; smart00924 391626007647 FliG C-terminal domain; Region: FliG_C; pfam01706 391626007648 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 391626007649 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 391626007650 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 391626007651 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 391626007652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007653 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391626007654 Walker A motif; other site 391626007655 ATP binding site [chemical binding]; other site 391626007656 Walker B motif; other site 391626007657 arginine finger; other site 391626007658 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 391626007659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007660 Walker A motif; other site 391626007661 ATP binding site [chemical binding]; other site 391626007662 Walker B motif; other site 391626007663 arginine finger; other site 391626007664 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 391626007665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626007666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626007667 DNA binding residues [nucleotide binding] 391626007668 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 391626007669 AAA domain; Region: AAA_31; pfam13614 391626007670 P-loop; other site 391626007671 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391626007672 flagellin; Reviewed; Region: PRK08869 391626007673 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391626007674 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391626007675 Sel1-like repeats; Region: SEL1; smart00671 391626007676 SAF-like; Region: SAF_2; pfam13144 391626007677 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391626007678 LPP20 lipoprotein; Region: LPP20; pfam02169 391626007679 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 391626007680 FHIPEP family; Region: FHIPEP; pfam00771 391626007681 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 391626007682 AAA domain; Region: AAA_17; pfam13207 391626007683 Flagellar protein FliS; Region: FliS; cl00654 391626007684 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 391626007685 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391626007686 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 391626007687 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 391626007688 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 391626007689 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626007690 ligand binding site [chemical binding]; other site 391626007691 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 391626007692 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391626007693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007694 Walker A motif; other site 391626007695 ATP binding site [chemical binding]; other site 391626007696 Walker B motif; other site 391626007697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391626007698 Peptidase M15; Region: Peptidase_M15_3; cl01194 391626007699 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 391626007700 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626007701 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 391626007702 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391626007703 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 391626007704 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 391626007705 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391626007706 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626007707 Rod binding protein; Region: Rod-binding; pfam10135 391626007708 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 391626007709 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 391626007710 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 391626007711 Flagellar L-ring protein; Region: FlgH; pfam02107 391626007712 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 391626007713 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391626007714 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391626007715 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 391626007716 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626007717 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391626007718 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391626007719 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626007720 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 391626007721 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391626007722 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391626007723 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 391626007724 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391626007725 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626007726 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 391626007727 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 391626007728 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 391626007729 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 391626007730 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 391626007731 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626007732 Integrase core domain; Region: rve_3; pfam13683 391626007733 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007734 MULE transposase domain; Region: MULE; pfam10551 391626007735 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 391626007736 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 391626007737 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 391626007738 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 391626007739 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391626007740 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391626007741 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626007742 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626007743 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626007744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 391626007745 DNA binding residues [nucleotide binding] 391626007746 dimerization interface [polypeptide binding]; other site 391626007747 Transposase; Region: HTH_Tnp_1; cl17663 391626007748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007749 Integrase core domain; Region: rve; pfam00665 391626007750 Integrase core domain; Region: rve_3; pfam13683 391626007751 H-NS histone family; Region: Histone_HNS; pfam00816 391626007752 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391626007753 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391626007754 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 391626007755 EamA-like transporter family; Region: EamA; pfam00892 391626007756 EamA-like transporter family; Region: EamA; pfam00892 391626007757 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 391626007758 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626007759 phosphate binding site [ion binding]; other site 391626007760 Cupin domain; Region: Cupin_2; cl17218 391626007761 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007762 MULE transposase domain; Region: MULE; pfam10551 391626007763 Transposase domain (DUF772); Region: DUF772; pfam05598 391626007764 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 391626007765 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391626007766 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391626007767 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626007768 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626007769 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 391626007770 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 391626007771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007772 Walker A motif; other site 391626007773 ATP binding site [chemical binding]; other site 391626007774 Walker B motif; other site 391626007775 arginine finger; other site 391626007776 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 391626007777 putative dimer interface [polypeptide binding]; other site 391626007778 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391626007779 Gas vesicle protein G; Region: GvpG; pfam05120 391626007780 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 391626007781 Gas vesicle protein; Region: Gas_vesicle; pfam00741 391626007782 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391626007783 DnaJ domain; Region: DnaJ; pfam00226 391626007784 HSP70 interaction site [polypeptide binding]; other site 391626007785 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391626007786 Gas vesicle protein; Region: Gas_vesicle; cl02954 391626007787 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391626007788 Gas vesicle protein K; Region: GvpK; pfam05121 391626007789 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007790 MULE transposase domain; Region: MULE; pfam10551 391626007791 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007792 MULE transposase domain; Region: MULE; pfam10551 391626007793 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007794 MULE transposase domain; Region: MULE; pfam10551 391626007795 Integrase core domain; Region: rve; pfam00665 391626007796 Integrase core domain; Region: rve_3; pfam13683 391626007797 Transposase; Region: HTH_Tnp_1; cl17663 391626007798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007800 Transposase; Region: HTH_Tnp_1; cl17663 391626007801 putative transposase OrfB; Reviewed; Region: PHA02517 391626007802 HTH-like domain; Region: HTH_21; pfam13276 391626007803 Integrase core domain; Region: rve; pfam00665 391626007804 Integrase core domain; Region: rve_3; pfam13683 391626007805 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391626007806 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626007807 catalytic residue [active] 391626007808 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391626007809 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 391626007810 active site 391626007811 metal-binding site 391626007812 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626007813 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391626007814 transposase/IS protein; Provisional; Region: PRK09183 391626007815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626007816 Walker A motif; other site 391626007817 ATP binding site [chemical binding]; other site 391626007818 Walker B motif; other site 391626007819 arginine finger; other site 391626007820 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007821 MULE transposase domain; Region: MULE; pfam10551 391626007822 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626007823 MULE transposase domain; Region: MULE; pfam10551 391626007824 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391626007825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626007826 active site 391626007827 DNA binding site [nucleotide binding] 391626007828 Int/Topo IB signature motif; other site 391626007829 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626007830 active site 391626007831 DNA binding site [nucleotide binding] 391626007832 Int/Topo IB signature motif; other site 391626007833 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391626007834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626007835 DNA-binding site [nucleotide binding]; DNA binding site 391626007836 FCD domain; Region: FCD; pfam07729 391626007837 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626007838 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391626007839 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626007840 DctM-like transporters; Region: DctM; pfam06808 391626007841 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626007842 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391626007843 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626007844 phosphate binding site [ion binding]; other site 391626007845 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391626007846 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391626007847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626007848 NAD(P) binding site [chemical binding]; other site 391626007849 active site 391626007850 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 391626007851 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391626007852 active site 391626007853 intersubunit interface [polypeptide binding]; other site 391626007854 catalytic residue [active] 391626007855 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391626007856 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391626007857 hypothetical protein; Validated; Region: PRK06201 391626007858 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 391626007859 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 391626007860 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 391626007861 ligand binding site [chemical binding]; other site 391626007862 NAD binding site [chemical binding]; other site 391626007863 catalytic site [active] 391626007864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626007865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391626007866 active site 391626007867 metal binding site [ion binding]; metal-binding site 391626007868 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626007869 classical (c) SDRs; Region: SDR_c; cd05233 391626007870 NAD(P) binding site [chemical binding]; other site 391626007871 active site 391626007872 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626007873 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626007874 TM-ABC transporter signature motif; other site 391626007875 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626007876 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626007877 Walker A/P-loop; other site 391626007878 ATP binding site [chemical binding]; other site 391626007879 Q-loop/lid; other site 391626007880 ABC transporter signature motif; other site 391626007881 Walker B; other site 391626007882 D-loop; other site 391626007883 H-loop/switch region; other site 391626007884 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626007885 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391626007886 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626007887 ligand binding site [chemical binding]; other site 391626007888 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391626007889 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391626007890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626007891 DNA-binding site [nucleotide binding]; DNA binding site 391626007892 FCD domain; Region: FCD; pfam07729 391626007893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626007894 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626007895 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626007896 HTH-like domain; Region: HTH_21; pfam13276 391626007897 Integrase core domain; Region: rve; pfam00665 391626007898 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391626007899 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626007900 DNA-binding site [nucleotide binding]; DNA binding site 391626007901 FCD domain; Region: FCD; pfam07729 391626007902 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626007903 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391626007904 dimer interface [polypeptide binding]; other site 391626007905 active site 391626007906 metal binding site [ion binding]; metal-binding site 391626007907 glutathione binding site [chemical binding]; other site 391626007908 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391626007909 FAD binding domain; Region: FAD_binding_4; pfam01565 391626007910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626007911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626007912 active site 391626007913 phosphorylation site [posttranslational modification] 391626007914 intermolecular recognition site; other site 391626007915 dimerization interface [polypeptide binding]; other site 391626007916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626007917 DNA binding site [nucleotide binding] 391626007918 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626007919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626007920 classical (c) SDRs; Region: SDR_c; cd05233 391626007921 NAD(P) binding site [chemical binding]; other site 391626007922 active site 391626007923 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626007924 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626007925 TM-ABC transporter signature motif; other site 391626007926 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626007927 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626007928 Walker A/P-loop; other site 391626007929 ATP binding site [chemical binding]; other site 391626007930 Q-loop/lid; other site 391626007931 ABC transporter signature motif; other site 391626007932 Walker B; other site 391626007933 D-loop; other site 391626007934 H-loop/switch region; other site 391626007935 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626007936 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626007937 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626007938 TM-ABC transporter signature motif; other site 391626007939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391626007940 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391626007941 ligand binding site [chemical binding]; other site 391626007942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626007943 Transposase; Region: HTH_Tnp_1; cl17663 391626007944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391626007945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626007946 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391626007947 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 391626007948 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626007949 dimer interface [polypeptide binding]; other site 391626007950 active site 391626007951 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 391626007952 Coenzyme A transferase; Region: CoA_trans; cl17247 391626007953 FAD binding domain; Region: FAD_binding_3; pfam01494 391626007954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626007955 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391626007956 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 391626007957 active site 391626007958 dimer interface [polypeptide binding]; other site 391626007959 metal binding site [ion binding]; metal-binding site 391626007960 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 391626007961 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 391626007962 active site 391626007963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391626007964 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 391626007965 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391626007966 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626007967 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626007968 TM-ABC transporter signature motif; other site 391626007969 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626007970 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626007971 TM-ABC transporter signature motif; other site 391626007972 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626007973 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626007974 Walker A/P-loop; other site 391626007975 ATP binding site [chemical binding]; other site 391626007976 Q-loop/lid; other site 391626007977 ABC transporter signature motif; other site 391626007978 Walker B; other site 391626007979 D-loop; other site 391626007980 H-loop/switch region; other site 391626007981 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626007982 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626007983 Walker A/P-loop; other site 391626007984 ATP binding site [chemical binding]; other site 391626007985 Q-loop/lid; other site 391626007986 ABC transporter signature motif; other site 391626007987 Walker B; other site 391626007988 D-loop; other site 391626007989 H-loop/switch region; other site 391626007990 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626007991 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337 391626007992 putative ligand binding site [chemical binding]; other site 391626007993 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391626007994 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391626007995 classical (c) SDRs; Region: SDR_c; cd05233 391626007996 NAD(P) binding site [chemical binding]; other site 391626007997 active site 391626007998 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 391626007999 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391626008000 N-terminal domain interface [polypeptide binding]; other site 391626008001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626008002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626008003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391626008004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626008005 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391626008006 putative effector binding pocket; other site 391626008007 dimerization interface [polypeptide binding]; other site 391626008008 short chain dehydrogenase; Provisional; Region: PRK06500 391626008009 classical (c) SDRs; Region: SDR_c; cd05233 391626008010 NAD(P) binding site [chemical binding]; other site 391626008011 active site 391626008012 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391626008013 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626008014 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391626008015 dimer interface [polypeptide binding]; other site 391626008016 substrate binding pocket (H-site) [chemical binding]; other site 391626008017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626008018 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391626008019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008020 active site 391626008021 DNA binding site [nucleotide binding] 391626008022 Int/Topo IB signature motif; other site 391626008023 Helix-turn-helix domain; Region: HTH_17; pfam12728 391626008024 Transposase; Region: HTH_Tnp_1; pfam01527 391626008025 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008026 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391626008027 active site 391626008028 Int/Topo IB signature motif; other site 391626008029 DNA binding site [nucleotide binding] 391626008030 Helix-turn-helix domain; Region: HTH_17; pfam12728 391626008031 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 391626008032 M28 Zn-Peptidases; Region: M28_like_3; cd05644 391626008033 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 391626008034 active site 391626008035 metal binding site [ion binding]; metal-binding site 391626008036 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391626008037 AAA-like domain; Region: AAA_10; pfam12846 391626008038 Walker A motif; other site 391626008039 ATP binding site [chemical binding]; other site 391626008040 Walker B motif; other site 391626008041 Protein of unknown function (DUF3768); Region: DUF3768; pfam12599 391626008042 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391626008043 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391626008044 catalytic residues [active] 391626008045 catalytic nucleophile [active] 391626008046 Recombinase; Region: Recombinase; pfam07508 391626008047 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391626008048 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626008049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626008050 non-specific DNA binding site [nucleotide binding]; other site 391626008051 salt bridge; other site 391626008052 sequence-specific DNA binding site [nucleotide binding]; other site 391626008053 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 391626008054 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391626008055 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 391626008056 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 391626008057 Int/Topo IB signature motif; other site 391626008058 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008059 active site 391626008060 DNA binding site [nucleotide binding] 391626008061 Int/Topo IB signature motif; other site 391626008062 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 391626008063 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626008064 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626008065 AAA-like domain; Region: AAA_10; pfam12846 391626008066 Domain of unknown function DUF87; Region: DUF87; pfam01935 391626008067 Replication-relaxation; Region: Replic_Relax; pfam13814 391626008068 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 391626008069 Domain of unknown function (DUF329); Region: DUF329; cl01144 391626008070 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626008071 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391626008072 mercuric reductase; Region: MerA; TIGR02053 391626008073 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626008074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626008075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626008076 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 391626008077 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 391626008078 metal-binding site [ion binding] 391626008079 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391626008080 DNA binding residues [nucleotide binding] 391626008081 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 391626008082 dimer interface [polypeptide binding]; other site 391626008083 putative metal binding site [ion binding]; other site 391626008084 Y-family of DNA polymerases; Region: PolY; cl12025 391626008085 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391626008086 HTH-like domain; Region: HTH_21; pfam13276 391626008087 Integrase core domain; Region: rve_3; pfam13683 391626008088 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008089 Int/Topo IB signature motif; other site 391626008090 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626008091 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626008092 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626008093 DctM-like transporters; Region: DctM; pfam06808 391626008094 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626008095 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 391626008096 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 391626008097 LCCL domain; Region: LCCL; cl02694 391626008098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626008099 Transposase; Region: HTH_Tnp_1; cl17663 391626008100 putative transposase OrfB; Reviewed; Region: PHA02517 391626008101 HTH-like domain; Region: HTH_21; pfam13276 391626008102 Integrase core domain; Region: rve; pfam00665 391626008103 Integrase core domain; Region: rve_3; pfam13683 391626008104 malonyl-CoA synthase; Validated; Region: PRK07514 391626008105 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 391626008106 acyl-activating enzyme (AAE) consensus motif; other site 391626008107 active site 391626008108 AMP binding site [chemical binding]; other site 391626008109 CoA binding site [chemical binding]; other site 391626008110 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 391626008111 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626008112 DctM-like transporters; Region: DctM; pfam06808 391626008113 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391626008114 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391626008115 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 391626008116 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391626008117 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391626008118 substrate binding site [chemical binding]; other site 391626008119 ligand binding site [chemical binding]; other site 391626008120 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391626008121 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391626008122 Bacterial transcriptional regulator; Region: IclR; pfam01614 391626008123 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391626008124 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391626008125 tetramer interface [polypeptide binding]; other site 391626008126 active site 391626008127 Mg2+/Mn2+ binding site [ion binding]; other site 391626008128 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391626008129 Amidase; Region: Amidase; cl11426 391626008130 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391626008131 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391626008132 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391626008133 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391626008134 hypothetical protein; Provisional; Region: PRK14851 391626008135 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626008136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391626008137 Ligand Binding Site [chemical binding]; other site 391626008138 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391626008139 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391626008140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626008141 dimer interface [polypeptide binding]; other site 391626008142 conserved gate region; other site 391626008143 putative PBP binding loops; other site 391626008144 ABC-ATPase subunit interface; other site 391626008145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626008146 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391626008147 Walker A/P-loop; other site 391626008148 ATP binding site [chemical binding]; other site 391626008149 Q-loop/lid; other site 391626008150 ABC transporter signature motif; other site 391626008151 Walker B; other site 391626008152 D-loop; other site 391626008153 H-loop/switch region; other site 391626008154 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 391626008155 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391626008156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626008157 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626008158 HYR domain; Region: HYR; pfam02494 391626008159 Autotransporter beta-domain; Region: Autotransporter; cl17461 391626008160 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 391626008161 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 391626008162 putative active site [active] 391626008163 putative NTP binding site [chemical binding]; other site 391626008164 putative nucleic acid binding site [nucleotide binding]; other site 391626008165 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626008166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391626008167 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008168 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626008169 active site 391626008170 Int/Topo IB signature motif; other site 391626008171 catalytic residues [active] 391626008172 DNA binding site [nucleotide binding] 391626008173 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391626008174 Helix-turn-helix domain; Region: HTH_17; cl17695 391626008175 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391626008176 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626008177 active site 391626008178 Int/Topo IB signature motif; other site 391626008179 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 391626008180 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391626008181 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391626008182 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 391626008183 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391626008184 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391626008185 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391626008186 dimer interface [polypeptide binding]; other site 391626008187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626008188 catalytic residue [active] 391626008189 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391626008190 putative active site pocket [active] 391626008191 dimerization interface [polypeptide binding]; other site 391626008192 putative catalytic residue [active] 391626008193 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 391626008194 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391626008195 dimer interface [polypeptide binding]; other site 391626008196 ADP-ribose binding site [chemical binding]; other site 391626008197 active site 391626008198 nudix motif; other site 391626008199 metal binding site [ion binding]; metal-binding site 391626008200 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 391626008201 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626008202 S-adenosylmethionine binding site [chemical binding]; other site 391626008203 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391626008204 DNA photolyase; Region: DNA_photolyase; pfam00875 391626008205 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 391626008206 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 391626008207 NADP binding site [chemical binding]; other site 391626008208 dimer interface [polypeptide binding]; other site 391626008209 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391626008210 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626008211 DinB family; Region: DinB; cl17821 391626008212 DinB superfamily; Region: DinB_2; pfam12867 391626008213 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 391626008214 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 391626008215 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 391626008216 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391626008217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626008218 DNA-binding site [nucleotide binding]; DNA binding site 391626008219 FCD domain; Region: FCD; pfam07729 391626008220 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391626008221 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626008222 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626008223 putative DNA binding site [nucleotide binding]; other site 391626008224 putative Zn2+ binding site [ion binding]; other site 391626008225 AsnC family; Region: AsnC_trans_reg; pfam01037 391626008226 siroheme synthase; Provisional; Region: cysG; PRK10637 391626008227 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 391626008228 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 391626008229 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391626008230 active site 391626008231 SAM binding site [chemical binding]; other site 391626008232 homodimer interface [polypeptide binding]; other site 391626008233 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 391626008234 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391626008235 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391626008236 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391626008237 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 391626008238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391626008239 Active Sites [active] 391626008240 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 391626008241 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391626008242 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391626008243 FAD binding pocket [chemical binding]; other site 391626008244 FAD binding motif [chemical binding]; other site 391626008245 phosphate binding motif [ion binding]; other site 391626008246 beta-alpha-beta structure motif; other site 391626008247 NAD binding pocket [chemical binding]; other site 391626008248 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 391626008249 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391626008250 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391626008251 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391626008252 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391626008253 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391626008254 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626008255 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626008256 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391626008257 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391626008258 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626008259 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391626008260 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391626008261 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391626008262 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391626008263 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 391626008264 Integrase core domain; Region: rve_3; pfam13683 391626008265 Hint domain; Region: Hint_2; pfam13403 391626008266 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 391626008267 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 391626008268 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 391626008269 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626008270 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626008271 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 391626008272 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626008273 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626008274 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626008275 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391626008276 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391626008277 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391626008278 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626008279 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391626008280 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391626008281 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626008282 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 391626008283 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 391626008284 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 391626008285 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 391626008286 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391626008287 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391626008288 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391626008289 FMN binding site [chemical binding]; other site 391626008290 active site 391626008291 catalytic residues [active] 391626008292 substrate binding site [chemical binding]; other site 391626008293 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391626008294 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391626008295 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391626008296 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391626008297 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 391626008298 IHF dimer interface [polypeptide binding]; other site 391626008299 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391626008300 Found in ATP-dependent protease La (LON); Region: LON; smart00464 391626008301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626008302 Walker A motif; other site 391626008303 ATP binding site [chemical binding]; other site 391626008304 Walker B motif; other site 391626008305 arginine finger; other site 391626008306 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391626008307 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 391626008308 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 391626008309 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 391626008310 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 391626008311 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391626008312 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 391626008313 MarR family; Region: MarR_2; pfam12802 391626008314 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 391626008315 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391626008316 TfoX N-terminal domain; Region: TfoX_N; pfam04993 391626008317 oxidase reductase; Provisional; Region: PTZ00273 391626008318 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 391626008319 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 391626008320 triosephosphate isomerase; Provisional; Region: PRK14565 391626008321 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391626008322 substrate binding site [chemical binding]; other site 391626008323 dimer interface [polypeptide binding]; other site 391626008324 catalytic triad [active] 391626008325 DctM-like transporters; Region: DctM; pfam06808 391626008326 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626008327 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391626008328 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391626008329 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391626008330 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391626008331 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391626008332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626008333 active site 391626008334 phosphorylation site [posttranslational modification] 391626008335 intermolecular recognition site; other site 391626008336 dimerization interface [polypeptide binding]; other site 391626008337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626008338 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391626008339 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391626008340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626008341 dimer interface [polypeptide binding]; other site 391626008342 phosphorylation site [posttranslational modification] 391626008343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626008344 ATP binding site [chemical binding]; other site 391626008345 Mg2+ binding site [ion binding]; other site 391626008346 G-X-G motif; other site 391626008347 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391626008348 Cytochrome P450; Region: p450; cl12078 391626008349 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391626008350 active site residue [active] 391626008351 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 391626008352 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 391626008353 Chromate transporter; Region: Chromate_transp; pfam02417 391626008354 Stringent starvation protein B; Region: SspB; pfam04386 391626008355 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391626008356 Class II fumarases; Region: Fumarase_classII; cd01362 391626008357 active site 391626008358 tetramer interface [polypeptide binding]; other site 391626008359 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 391626008360 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 391626008361 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391626008362 Cytochrome P450; Region: p450; cl12078 391626008363 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391626008364 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391626008365 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 391626008366 CPxP motif; other site 391626008367 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391626008368 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391626008369 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391626008370 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391626008371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626008372 active site 391626008373 phosphorylation site [posttranslational modification] 391626008374 intermolecular recognition site; other site 391626008375 dimerization interface [polypeptide binding]; other site 391626008376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626008377 Walker A motif; other site 391626008378 ATP binding site [chemical binding]; other site 391626008379 Walker B motif; other site 391626008380 arginine finger; other site 391626008381 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391626008382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626008383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626008384 dimer interface [polypeptide binding]; other site 391626008385 phosphorylation site [posttranslational modification] 391626008386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626008387 ATP binding site [chemical binding]; other site 391626008388 Mg2+ binding site [ion binding]; other site 391626008389 G-X-G motif; other site 391626008390 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 391626008391 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391626008392 putative active site [active] 391626008393 catalytic triad [active] 391626008394 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 391626008395 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 391626008396 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 391626008397 ATP binding site [chemical binding]; other site 391626008398 active site 391626008399 substrate binding site [chemical binding]; other site 391626008400 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 391626008401 methionine synthase I; Validated; Region: PRK07534 391626008402 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391626008403 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 391626008404 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 391626008405 B12 binding site [chemical binding]; other site 391626008406 cobalt ligand [ion binding]; other site 391626008407 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 391626008408 glutathionine S-transferase; Provisional; Region: PRK10542 391626008409 C-terminal domain interface [polypeptide binding]; other site 391626008410 GSH binding site (G-site) [chemical binding]; other site 391626008411 dimer interface [polypeptide binding]; other site 391626008412 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 391626008413 dimer interface [polypeptide binding]; other site 391626008414 N-terminal domain interface [polypeptide binding]; other site 391626008415 substrate binding pocket (H-site) [chemical binding]; other site 391626008416 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 391626008417 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626008418 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626008419 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 391626008420 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 391626008421 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391626008422 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391626008423 catalytic site [active] 391626008424 putative active site [active] 391626008425 putative substrate binding site [chemical binding]; other site 391626008426 HRDC domain; Region: HRDC; pfam00570 391626008427 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391626008428 active site 391626008429 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391626008430 cosubstrate binding site; other site 391626008431 substrate binding site [chemical binding]; other site 391626008432 catalytic site [active] 391626008433 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391626008434 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 391626008435 dimerization interface [polypeptide binding]; other site 391626008436 putative ATP binding site [chemical binding]; other site 391626008437 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 391626008438 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 391626008439 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626008440 Walker B; other site 391626008441 D-loop; other site 391626008442 H-loop/switch region; other site 391626008443 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391626008444 Dynamin family; Region: Dynamin_N; pfam00350 391626008445 G1 box; other site 391626008446 GTP/Mg2+ binding site [chemical binding]; other site 391626008447 G2 box; other site 391626008448 Switch I region; other site 391626008449 G3 box; other site 391626008450 Switch II region; other site 391626008451 G4 box; other site 391626008452 G5 box; other site 391626008453 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 391626008454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626008455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626008456 DNA binding residues [nucleotide binding] 391626008457 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 391626008458 Putative zinc-finger; Region: zf-HC2; pfam13490 391626008459 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 391626008460 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 391626008461 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 391626008462 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 391626008463 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 391626008464 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 391626008465 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626008466 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 391626008467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626008468 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 391626008469 HTH-like domain; Region: HTH_21; pfam13276 391626008470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626008471 Integrase core domain; Region: rve; pfam00665 391626008472 Integrase core domain; Region: rve_3; pfam13683 391626008473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626008474 Transposase; Region: HTH_Tnp_1; cl17663 391626008475 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626008476 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626008477 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626008478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626008479 Integrase core domain; Region: rve; pfam00665 391626008480 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626008481 substrate binding site [chemical binding]; other site 391626008482 oxyanion hole (OAH) forming residues; other site 391626008483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626008484 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391626008485 active site 391626008486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626008487 NAD(P) binding site [chemical binding]; other site 391626008488 active site 391626008489 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 391626008490 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626008491 dimer interface [polypeptide binding]; other site 391626008492 active site 391626008493 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626008494 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 391626008495 acyl-activating enzyme (AAE) consensus motif; other site 391626008496 active site 391626008497 AMP binding site [chemical binding]; other site 391626008498 CoA binding site [chemical binding]; other site 391626008499 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626008500 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391626008501 Walker A/P-loop; other site 391626008502 ATP binding site [chemical binding]; other site 391626008503 Q-loop/lid; other site 391626008504 ABC transporter signature motif; other site 391626008505 Walker B; other site 391626008506 D-loop; other site 391626008507 H-loop/switch region; other site 391626008508 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 391626008509 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626008510 putative ligand binding site [chemical binding]; other site 391626008511 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391626008512 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391626008513 TM-ABC transporter signature motif; other site 391626008514 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391626008515 TM-ABC transporter signature motif; other site 391626008516 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391626008517 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391626008518 Walker A/P-loop; other site 391626008519 ATP binding site [chemical binding]; other site 391626008520 Q-loop/lid; other site 391626008521 ABC transporter signature motif; other site 391626008522 Walker B; other site 391626008523 D-loop; other site 391626008524 H-loop/switch region; other site 391626008525 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391626008526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626008527 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391626008528 acyl-activating enzyme (AAE) consensus motif; other site 391626008529 putative AMP binding site [chemical binding]; other site 391626008530 putative active site [active] 391626008531 putative CoA binding site [chemical binding]; other site 391626008532 PAS fold; Region: PAS_7; pfam12860 391626008533 PAS fold; Region: PAS_4; pfam08448 391626008534 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626008535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 391626008536 dimer interface [polypeptide binding]; other site 391626008537 phosphorylation site [posttranslational modification] 391626008538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626008539 ATP binding site [chemical binding]; other site 391626008540 Mg2+ binding site [ion binding]; other site 391626008541 G-X-G motif; other site 391626008542 Response regulator receiver domain; Region: Response_reg; pfam00072 391626008543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626008544 active site 391626008545 phosphorylation site [posttranslational modification] 391626008546 intermolecular recognition site; other site 391626008547 dimerization interface [polypeptide binding]; other site 391626008548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626008550 active site 391626008551 phosphorylation site [posttranslational modification] 391626008552 intermolecular recognition site; other site 391626008553 dimerization interface [polypeptide binding]; other site 391626008554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626008555 DNA binding site [nucleotide binding] 391626008556 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008557 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626008558 active site 391626008559 DNA binding site [nucleotide binding] 391626008560 Int/Topo IB signature motif; other site 391626008561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626008562 electron transport complex protein RnfC; Provisional; Region: PRK05035 391626008563 Transposase; Region: HTH_Tnp_1; cl17663 391626008564 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626008565 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 391626008566 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391626008567 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391626008568 active site 391626008569 catalytic tetrad [active] 391626008570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626008571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626008572 putative substrate translocation pore; other site 391626008573 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 391626008574 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391626008575 active site 391626008576 HIGH motif; other site 391626008577 KMSKS motif; other site 391626008578 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391626008579 tRNA binding surface [nucleotide binding]; other site 391626008580 anticodon binding site; other site 391626008581 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391626008582 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626008583 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626008584 catalytic residue [active] 391626008585 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626008586 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626008587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626008588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626008589 non-specific DNA binding site [nucleotide binding]; other site 391626008590 salt bridge; other site 391626008591 sequence-specific DNA binding site [nucleotide binding]; other site 391626008592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391626008593 TPR motif; other site 391626008594 binding surface 391626008595 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391626008596 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626008597 putative DNA binding site [nucleotide binding]; other site 391626008598 putative Zn2+ binding site [ion binding]; other site 391626008599 AsnC family; Region: AsnC_trans_reg; pfam01037 391626008600 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 391626008601 Proline dehydrogenase; Region: Pro_dh; pfam01619 391626008602 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 391626008603 Glutamate binding site [chemical binding]; other site 391626008604 NAD binding site [chemical binding]; other site 391626008605 catalytic residues [active] 391626008606 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391626008607 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 391626008608 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391626008609 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626008610 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391626008611 active site 391626008612 metal binding site [ion binding]; metal-binding site 391626008613 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391626008614 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391626008615 active site 391626008616 dimerization interface [polypeptide binding]; other site 391626008617 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391626008618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626008619 metal binding site [ion binding]; metal-binding site 391626008620 active site 391626008621 I-site; other site 391626008622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626008623 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 391626008624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626008625 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 391626008626 putative dimerization interface [polypeptide binding]; other site 391626008627 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 391626008628 FAD binding site [chemical binding]; other site 391626008629 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626008630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626008631 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626008632 Integrase core domain; Region: rve; pfam00665 391626008633 Integrase core domain; Region: rve_3; pfam13683 391626008634 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626008635 Winged helix-turn helix; Region: HTH_29; pfam13551 391626008636 Homeodomain-like domain; Region: HTH_32; pfam13565 391626008637 Integrase core domain; Region: rve; pfam00665 391626008638 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391626008639 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391626008640 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626008641 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626008642 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 391626008643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626008644 active site 391626008645 HIGH motif; other site 391626008646 nucleotide binding site [chemical binding]; other site 391626008647 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626008648 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626008649 active site 391626008650 KMSKS motif; other site 391626008651 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391626008652 tRNA binding surface [nucleotide binding]; other site 391626008653 anticodon binding site; other site 391626008654 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 391626008655 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391626008656 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 391626008657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626008658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626008659 homodimer interface [polypeptide binding]; other site 391626008660 catalytic residue [active] 391626008661 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391626008662 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626008663 catalytic residue [active] 391626008664 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391626008665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626008666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626008667 Walker A/P-loop; other site 391626008668 ATP binding site [chemical binding]; other site 391626008669 Q-loop/lid; other site 391626008670 ABC transporter signature motif; other site 391626008671 Walker B; other site 391626008672 D-loop; other site 391626008673 H-loop/switch region; other site 391626008674 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 391626008675 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391626008676 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626008677 elongation factor P; Validated; Region: PRK00529 391626008678 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391626008679 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 391626008680 RNA binding site [nucleotide binding]; other site 391626008681 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 391626008682 RNA binding site [nucleotide binding]; other site 391626008683 cobyric acid synthase; Provisional; Region: PRK00784 391626008684 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 391626008685 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391626008686 catalytic triad [active] 391626008687 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391626008688 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 391626008689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626008690 S-adenosylmethionine binding site [chemical binding]; other site 391626008691 Transposase; Region: HTH_Tnp_1; cl17663 391626008692 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391626008693 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626008694 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626008695 Hint domain; Region: Hint_2; pfam13403 391626008696 Transposase; Region: HTH_Tnp_1; pfam01527 391626008697 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626008698 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626008699 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626008700 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 391626008701 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626008702 phosphate binding site [ion binding]; other site 391626008703 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391626008704 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391626008705 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391626008706 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626008707 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626008708 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626008709 Walker A/P-loop; other site 391626008710 ATP binding site [chemical binding]; other site 391626008711 Q-loop/lid; other site 391626008712 ABC transporter signature motif; other site 391626008713 Walker B; other site 391626008714 D-loop; other site 391626008715 H-loop/switch region; other site 391626008716 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626008717 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626008718 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626008719 TM-ABC transporter signature motif; other site 391626008720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626008721 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626008722 TM-ABC transporter signature motif; other site 391626008723 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626008724 acetoin reductases; Region: 23BDH; TIGR02415 391626008725 NAD(P) binding site [chemical binding]; other site 391626008726 active site 391626008727 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 391626008728 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626008729 putative ligand binding site [chemical binding]; other site 391626008730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391626008731 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626008732 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626008733 sorbitol dehydrogenase; Provisional; Region: PRK07067 391626008734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626008735 NAD(P) binding site [chemical binding]; other site 391626008736 active site 391626008737 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391626008738 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391626008739 active site 391626008740 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391626008741 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391626008742 tetramer interface [polypeptide binding]; other site 391626008743 TPP-binding site [chemical binding]; other site 391626008744 heterodimer interface [polypeptide binding]; other site 391626008745 phosphorylation loop region [posttranslational modification] 391626008746 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391626008747 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391626008748 alpha subunit interface [polypeptide binding]; other site 391626008749 TPP binding site [chemical binding]; other site 391626008750 heterodimer interface [polypeptide binding]; other site 391626008751 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391626008752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626008753 E3 interaction surface; other site 391626008754 lipoyl attachment site [posttranslational modification]; other site 391626008755 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626008756 E3 interaction surface; other site 391626008757 lipoyl attachment site [posttranslational modification]; other site 391626008758 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626008759 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391626008760 tetramerization interface [polypeptide binding]; other site 391626008761 NAD(P) binding site [chemical binding]; other site 391626008762 catalytic residues [active] 391626008763 e3 binding domain; Region: E3_binding; pfam02817 391626008764 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 391626008765 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391626008766 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626008767 Integrase core domain; Region: rve; pfam00665 391626008768 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626008769 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626008770 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626008771 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626008772 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 391626008773 HTH-like domain; Region: HTH_21; pfam13276 391626008774 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391626008775 Integrase core domain; Region: rve_3; pfam13683 391626008776 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626008777 SnoaL-like domain; Region: SnoaL_2; pfam12680 391626008778 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391626008779 SnoaL-like domain; Region: SnoaL_2; pfam12680 391626008780 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626008781 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626008782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626008783 dimer interface [polypeptide binding]; other site 391626008784 conserved gate region; other site 391626008785 putative PBP binding loops; other site 391626008786 ABC-ATPase subunit interface; other site 391626008787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626008788 dimer interface [polypeptide binding]; other site 391626008789 conserved gate region; other site 391626008790 putative PBP binding loops; other site 391626008791 ABC-ATPase subunit interface; other site 391626008792 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626008793 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626008794 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626008795 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626008796 Walker A/P-loop; other site 391626008797 ATP binding site [chemical binding]; other site 391626008798 Q-loop/lid; other site 391626008799 ABC transporter signature motif; other site 391626008800 Walker B; other site 391626008801 D-loop; other site 391626008802 H-loop/switch region; other site 391626008803 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391626008804 histidinol dehydrogenase; Region: hisD; TIGR00069 391626008805 NAD binding site [chemical binding]; other site 391626008806 dimerization interface [polypeptide binding]; other site 391626008807 product binding site; other site 391626008808 substrate binding site [chemical binding]; other site 391626008809 zinc binding site [ion binding]; other site 391626008810 catalytic residues [active] 391626008811 SnoaL-like domain; Region: SnoaL_2; pfam12680 391626008812 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626008813 short chain dehydrogenase; Provisional; Region: PRK07060 391626008814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626008815 NAD(P) binding site [chemical binding]; other site 391626008816 active site 391626008817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626008818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626008819 DNA binding site [nucleotide binding] 391626008820 domain linker motif; other site 391626008821 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391626008822 putative dimerization interface [polypeptide binding]; other site 391626008823 putative ligand binding site [chemical binding]; other site 391626008824 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626008825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626008826 Cupin domain; Region: Cupin_2; pfam07883 391626008827 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 391626008828 substrate binding site [chemical binding]; other site 391626008829 THF binding site; other site 391626008830 zinc-binding site [ion binding]; other site 391626008831 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626008832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391626008833 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391626008834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626008835 S-adenosylmethionine binding site [chemical binding]; other site 391626008836 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391626008837 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 391626008838 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391626008839 DNA binding residues [nucleotide binding] 391626008840 dimer interface [polypeptide binding]; other site 391626008841 putative metal binding site [ion binding]; other site 391626008842 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626008843 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626008844 Restriction endonuclease; Region: Mrr_cat; pfam04471 391626008845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391626008846 non-specific DNA binding site [nucleotide binding]; other site 391626008847 salt bridge; other site 391626008848 sequence-specific DNA binding site [nucleotide binding]; other site 391626008849 Resolvase, N terminal domain; Region: Resolvase; smart00857 391626008850 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391626008851 catalytic residues [active] 391626008852 catalytic nucleophile [active] 391626008853 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626008854 active site 391626008855 DNA binding site [nucleotide binding] 391626008856 Int/Topo IB signature motif; other site 391626008857 integrase; Provisional; Region: PRK09692 391626008858 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391626008859 active site 391626008860 Int/Topo IB signature motif; other site 391626008861 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391626008862 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391626008863 catalytic residues [active] 391626008864 catalytic nucleophile [active] 391626008865 Presynaptic Site I dimer interface [polypeptide binding]; other site 391626008866 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391626008867 Synaptic Flat tetramer interface [polypeptide binding]; other site 391626008868 Synaptic Site I dimer interface [polypeptide binding]; other site 391626008869 DNA binding site [nucleotide binding] 391626008870 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626008871 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626008872 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 391626008873 DNA binding residues [nucleotide binding] 391626008874 dimerization interface [polypeptide binding]; other site 391626008875 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391626008876 MULE transposase domain; Region: MULE; pfam10551 391626008877 Sensors of blue-light using FAD; Region: BLUF; smart01034 391626008878 transposase/IS protein; Provisional; Region: PRK09183 391626008879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626008880 Walker A motif; other site 391626008881 ATP binding site [chemical binding]; other site 391626008882 Walker B motif; other site 391626008883 arginine finger; other site 391626008884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626008885 Integrase core domain; Region: rve; pfam00665 391626008886 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 391626008887 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 391626008888 Autotransporter beta-domain; Region: Autotransporter; smart00869 391626008889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626008890 TPR motif; other site 391626008891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626008892 binding surface 391626008893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626008894 binding surface 391626008895 TPR motif; other site 391626008896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626008897 binding surface 391626008898 TPR motif; other site 391626008899 TPR repeat; Region: TPR_11; pfam13414 391626008900 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 391626008901 Sporulation related domain; Region: SPOR; pfam05036 391626008902 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391626008903 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391626008904 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 391626008905 thymidylate kinase; Validated; Region: tmk; PRK00698 391626008906 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 391626008907 TMP-binding site; other site 391626008908 ATP-binding site [chemical binding]; other site 391626008909 DNA polymerase III subunit delta'; Validated; Region: PRK07471 391626008910 DNA polymerase III subunit delta'; Validated; Region: PRK08485 391626008911 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391626008912 active site 391626008913 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 391626008914 putative hydrolase; Provisional; Region: PRK02113 391626008915 Predicted permeases [General function prediction only]; Region: COG0679 391626008916 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 391626008917 ArsC family; Region: ArsC; pfam03960 391626008918 catalytic residue [active] 391626008919 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 391626008920 Transposase; Region: HTH_Tnp_1; pfam01527 391626008921 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626008922 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391626008923 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391626008924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626008925 catalytic residue [active] 391626008926 FeS assembly protein SufD; Region: sufD; TIGR01981 391626008927 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 391626008928 FeS assembly ATPase SufC; Region: sufC; TIGR01978 391626008929 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 391626008930 Walker A/P-loop; other site 391626008931 ATP binding site [chemical binding]; other site 391626008932 Q-loop/lid; other site 391626008933 ABC transporter signature motif; other site 391626008934 Walker B; other site 391626008935 D-loop; other site 391626008936 H-loop/switch region; other site 391626008937 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 391626008938 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 391626008939 putative ABC transporter; Region: ycf24; CHL00085 391626008940 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626008941 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 391626008942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626008943 catalytic residue [active] 391626008944 Transcriptional regulator; Region: Rrf2; cl17282 391626008945 Rrf2 family protein; Region: rrf2_super; TIGR00738 391626008946 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 391626008947 HD domain; Region: HD_3; pfam13023 391626008948 HD domain; Region: HD_3; pfam13023 391626008949 isocitrate dehydrogenase; Validated; Region: PRK08299 391626008950 Uncharacterized conserved protein [Function unknown]; Region: COG1284 391626008951 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 391626008952 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391626008953 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 391626008954 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 391626008955 G1 box; other site 391626008956 putative GEF interaction site [polypeptide binding]; other site 391626008957 GTP/Mg2+ binding site [chemical binding]; other site 391626008958 Switch I region; other site 391626008959 G2 box; other site 391626008960 G3 box; other site 391626008961 Switch II region; other site 391626008962 G4 box; other site 391626008963 G5 box; other site 391626008964 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391626008965 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 391626008966 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391626008967 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 391626008968 motif 1; other site 391626008969 active site 391626008970 motif 2; other site 391626008971 motif 3; other site 391626008972 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391626008973 DHHA1 domain; Region: DHHA1; pfam02272 391626008974 recombinase A; Provisional; Region: recA; PRK09354 391626008975 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391626008976 hexamer interface [polypeptide binding]; other site 391626008977 Walker A motif; other site 391626008978 ATP binding site [chemical binding]; other site 391626008979 Walker B motif; other site 391626008980 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391626008981 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626008982 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626008983 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626008984 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 391626008985 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 391626008986 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 391626008987 putative active site [active] 391626008988 catalytic site [active] 391626008989 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 391626008990 putative active site [active] 391626008991 catalytic site [active] 391626008992 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626008993 putative catalytic site [active] 391626008994 putative metal binding site [ion binding]; other site 391626008995 putative phosphate binding site [ion binding]; other site 391626008996 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626008997 Winged helix-turn helix; Region: HTH_29; pfam13551 391626008998 Homeodomain-like domain; Region: HTH_32; pfam13565 391626008999 Integrase core domain; Region: rve; pfam00665 391626009000 Integrase core domain; Region: rve; pfam00665 391626009001 Integrase core domain; Region: rve_3; pfam13683 391626009002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009003 Transposase; Region: HTH_Tnp_1; pfam01527 391626009004 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009005 DctM-like transporters; Region: DctM; pfam06808 391626009006 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626009007 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626009008 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626009009 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391626009010 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391626009011 substrate binding site [chemical binding]; other site 391626009012 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391626009013 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391626009014 substrate binding site [chemical binding]; other site 391626009015 ligand binding site [chemical binding]; other site 391626009016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391626009017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626009018 DNA-binding site [nucleotide binding]; DNA binding site 391626009019 UTRA domain; Region: UTRA; pfam07702 391626009020 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 391626009021 active site 1 [active] 391626009022 dimer interface [polypeptide binding]; other site 391626009023 hexamer interface [polypeptide binding]; other site 391626009024 active site 2 [active] 391626009025 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391626009026 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391626009027 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 391626009028 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391626009029 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626009030 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391626009031 Isochorismatase family; Region: Isochorismatase; pfam00857 391626009032 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 391626009033 catalytic triad [active] 391626009034 conserved cis-peptide bond; other site 391626009035 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391626009036 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391626009037 tetramer interface [polypeptide binding]; other site 391626009038 active site 391626009039 Mg2+/Mn2+ binding site [ion binding]; other site 391626009040 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 391626009041 L-aspartate oxidase; Provisional; Region: PRK06175 391626009042 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391626009043 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391626009044 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391626009045 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391626009046 FAD binding site [chemical binding]; other site 391626009047 substrate binding pocket [chemical binding]; other site 391626009048 catalytic base [active] 391626009049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626009050 S-adenosylmethionine binding site [chemical binding]; other site 391626009051 GSCFA family; Region: GSCFA; pfam08885 391626009052 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009053 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626009054 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626009055 UDP-galactopyranose mutase; Region: GLF; pfam03275 391626009056 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626009057 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 391626009058 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626009059 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 391626009060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 391626009061 TolQ protein; Region: tolQ; TIGR02796 391626009062 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 391626009063 TolR protein; Region: tolR; TIGR02801 391626009064 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391626009065 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391626009066 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391626009067 ligand binding site [chemical binding]; other site 391626009068 flexible hinge region; other site 391626009069 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 391626009070 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391626009071 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626009072 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 391626009073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 391626009074 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 391626009075 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626009076 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 391626009077 acyl-activating enzyme (AAE) consensus motif; other site 391626009078 putative AMP binding site [chemical binding]; other site 391626009079 putative active site [active] 391626009080 putative CoA binding site [chemical binding]; other site 391626009081 bile acid transporter; Region: bass; TIGR00841 391626009082 Sodium Bile acid symporter family; Region: SBF; pfam01758 391626009083 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 391626009084 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626009085 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626009086 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626009087 choline dehydrogenase; Validated; Region: PRK02106 391626009088 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626009089 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626009090 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626009091 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626009092 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626009093 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 391626009094 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626009095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626009096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626009097 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626009098 short chain dehydrogenase; Provisional; Region: PRK06198 391626009099 classical (c) SDRs; Region: SDR_c; cd05233 391626009100 NAD(P) binding site [chemical binding]; other site 391626009101 active site 391626009102 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391626009103 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391626009104 putative ligand binding site [chemical binding]; other site 391626009105 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391626009106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626009107 Walker A/P-loop; other site 391626009108 ATP binding site [chemical binding]; other site 391626009109 Q-loop/lid; other site 391626009110 ABC transporter signature motif; other site 391626009111 Walker B; other site 391626009112 D-loop; other site 391626009113 H-loop/switch region; other site 391626009114 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626009115 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626009116 TM-ABC transporter signature motif; other site 391626009117 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009118 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626009119 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009120 Transposase; Region: HTH_Tnp_1; cl17663 391626009121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009122 H-NS histone family; Region: Histone_HNS; pfam00816 391626009123 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391626009124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391626009125 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391626009126 Walker A motif; other site 391626009127 ATP binding site [chemical binding]; other site 391626009128 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626009129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626009130 ATP binding site [chemical binding]; other site 391626009131 G-X-G motif; other site 391626009132 Response regulator receiver domain; Region: Response_reg; pfam00072 391626009133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626009134 active site 391626009135 phosphorylation site [posttranslational modification] 391626009136 intermolecular recognition site; other site 391626009137 dimerization interface [polypeptide binding]; other site 391626009138 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 391626009139 Response regulator receiver domain; Region: Response_reg; pfam00072 391626009140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626009141 active site 391626009142 phosphorylation site [posttranslational modification] 391626009143 intermolecular recognition site; other site 391626009144 dimerization interface [polypeptide binding]; other site 391626009145 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391626009146 Transposase; Region: HTH_Tnp_1; pfam01527 391626009147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626009148 Integrase core domain; Region: rve_3; pfam13683 391626009149 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391626009150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626009151 S-adenosylmethionine binding site [chemical binding]; other site 391626009152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391626009153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626009154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626009155 dimer interface [polypeptide binding]; other site 391626009156 phosphorylation site [posttranslational modification] 391626009157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626009158 ATP binding site [chemical binding]; other site 391626009159 Mg2+ binding site [ion binding]; other site 391626009160 G-X-G motif; other site 391626009161 HTH-like domain; Region: HTH_21; pfam13276 391626009162 Transposase; Region: HTH_Tnp_1; cl17663 391626009163 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009164 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626009165 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009167 Transposase; Region: HTH_Tnp_1; cl17663 391626009168 putative transposase OrfB; Reviewed; Region: PHA02517 391626009169 HTH-like domain; Region: HTH_21; pfam13276 391626009170 Integrase core domain; Region: rve; pfam00665 391626009171 Integrase core domain; Region: rve_3; pfam13683 391626009172 Uncharacterized conserved protein [Function unknown]; Region: COG2135 391626009173 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 391626009174 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391626009175 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 391626009176 active site 391626009177 metal binding site [ion binding]; metal-binding site 391626009178 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391626009179 Protein of unknown function (DUF952); Region: DUF952; pfam06108 391626009180 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 391626009181 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 391626009182 quinone interaction residues [chemical binding]; other site 391626009183 active site 391626009184 catalytic residues [active] 391626009185 FMN binding site [chemical binding]; other site 391626009186 substrate binding site [chemical binding]; other site 391626009187 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 391626009188 ArsC family; Region: ArsC; pfam03960 391626009189 catalytic residues [active] 391626009190 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 391626009191 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 391626009192 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391626009193 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 391626009194 CoenzymeA binding site [chemical binding]; other site 391626009195 subunit interaction site [polypeptide binding]; other site 391626009196 PHB binding site; other site 391626009197 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391626009198 CoenzymeA binding site [chemical binding]; other site 391626009199 subunit interaction site [polypeptide binding]; other site 391626009200 PHB binding site; other site 391626009201 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391626009202 DNA binding residues [nucleotide binding] 391626009203 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391626009204 putative dimer interface [polypeptide binding]; other site 391626009205 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391626009206 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391626009207 DNA binding residues [nucleotide binding] 391626009208 putative dimer interface [polypeptide binding]; other site 391626009209 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391626009210 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391626009211 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 391626009212 FAD binding site [chemical binding]; other site 391626009213 substrate binding site [chemical binding]; other site 391626009214 catalytic residues [active] 391626009215 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391626009216 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626009217 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391626009218 putative C-terminal domain interface [polypeptide binding]; other site 391626009219 putative GSH binding site (G-site) [chemical binding]; other site 391626009220 putative dimer interface [polypeptide binding]; other site 391626009221 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391626009222 N-terminal domain interface [polypeptide binding]; other site 391626009223 dimer interface [polypeptide binding]; other site 391626009224 substrate binding pocket (H-site) [chemical binding]; other site 391626009225 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 391626009226 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626009227 dimer interface [polypeptide binding]; other site 391626009228 active site 391626009229 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391626009230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626009231 substrate binding site [chemical binding]; other site 391626009232 oxyanion hole (OAH) forming residues; other site 391626009233 trimer interface [polypeptide binding]; other site 391626009234 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391626009235 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391626009236 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391626009237 Alternative oxidase; Region: AOX; pfam01786 391626009238 dinuclear metal binding motif [ion binding]; other site 391626009239 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 391626009240 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391626009241 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391626009242 acyl-CoA synthetase; Validated; Region: PRK08162 391626009243 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391626009244 acyl-activating enzyme (AAE) consensus motif; other site 391626009245 putative active site [active] 391626009246 AMP binding site [chemical binding]; other site 391626009247 putative CoA binding site [chemical binding]; other site 391626009248 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391626009249 Ligand Binding Site [chemical binding]; other site 391626009250 BCCT family transporter; Region: BCCT; pfam02028 391626009251 Sporulation related domain; Region: SPOR; pfam05036 391626009252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626009253 active site 391626009254 adenosine deaminase; Provisional; Region: PRK09358 391626009255 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 391626009256 active site 391626009257 phosphopentomutase; Provisional; Region: PRK05362 391626009258 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 391626009259 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 391626009260 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391626009261 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391626009262 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 391626009263 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 391626009264 active site 391626009265 catalytic motif [active] 391626009266 Zn binding site [ion binding]; other site 391626009267 malic enzyme; Reviewed; Region: PRK12862 391626009268 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391626009269 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391626009270 putative NAD(P) binding site [chemical binding]; other site 391626009271 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391626009272 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 391626009273 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626009274 acyl-activating enzyme (AAE) consensus motif; other site 391626009275 AMP binding site [chemical binding]; other site 391626009276 active site 391626009277 CoA binding site [chemical binding]; other site 391626009278 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 391626009279 ATP-NAD kinase; Region: NAD_kinase; pfam01513 391626009280 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 391626009281 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391626009282 dimer interface [polypeptide binding]; other site 391626009283 active site 391626009284 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391626009285 folate binding site [chemical binding]; other site 391626009286 Protein of unknown function (DUF817); Region: DUF817; pfam05675 391626009287 PGAP1-like protein; Region: PGAP1; pfam07819 391626009288 acyl-CoA esterase; Provisional; Region: PRK10673 391626009289 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 391626009290 GTP-binding protein LepA; Provisional; Region: PRK05433 391626009291 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 391626009292 G1 box; other site 391626009293 putative GEF interaction site [polypeptide binding]; other site 391626009294 GTP/Mg2+ binding site [chemical binding]; other site 391626009295 Switch I region; other site 391626009296 G2 box; other site 391626009297 G3 box; other site 391626009298 Switch II region; other site 391626009299 G4 box; other site 391626009300 G5 box; other site 391626009301 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 391626009302 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391626009303 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391626009304 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391626009305 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391626009306 membrane ATPase/protein kinase; Provisional; Region: PRK09435 391626009307 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391626009308 Walker A; other site 391626009309 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 391626009310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626009311 ATP binding site [chemical binding]; other site 391626009312 putative Mg++ binding site [ion binding]; other site 391626009313 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391626009314 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 391626009315 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626009316 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 391626009317 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 391626009318 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 391626009319 active site 391626009320 catalytic triad [active] 391626009321 oxyanion hole [active] 391626009322 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391626009323 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391626009324 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391626009325 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 391626009326 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391626009327 inhibitor-cofactor binding pocket; inhibition site 391626009328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626009329 catalytic residue [active] 391626009330 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 391626009331 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626009332 EamA-like transporter family; Region: EamA; pfam00892 391626009333 EamA-like transporter family; Region: EamA; pfam00892 391626009334 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391626009335 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391626009336 GcrA cell cycle regulator; Region: GcrA; cl11564 391626009337 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391626009338 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391626009339 MarR family; Region: MarR; pfam01047 391626009340 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626009341 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626009342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391626009343 active site 391626009344 metal binding site [ion binding]; metal-binding site 391626009345 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391626009346 putative FMN binding site [chemical binding]; other site 391626009347 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626009348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626009349 non-specific DNA binding site [nucleotide binding]; other site 391626009350 salt bridge; other site 391626009351 sequence-specific DNA binding site [nucleotide binding]; other site 391626009352 CopC domain; Region: CopC; pfam04234 391626009353 Cytochrome c; Region: Cytochrom_C; pfam00034 391626009354 Protein of unknown function, DUF; Region: DUF411; cl01142 391626009355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626009356 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009357 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626009358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391626009359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626009360 catalytic residue [active] 391626009361 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009362 Transposase; Region: HTH_Tnp_1; cl17663 391626009363 HTH-like domain; Region: HTH_21; pfam13276 391626009364 Integrase core domain; Region: rve; pfam00665 391626009365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626009366 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626009367 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626009368 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391626009369 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626009370 Catalytic site [active] 391626009371 Integrase core domain; Region: rve; pfam00665 391626009372 Integrase core domain; Region: rve_3; pfam13683 391626009373 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626009374 Winged helix-turn helix; Region: HTH_29; pfam13551 391626009375 Homeodomain-like domain; Region: HTH_32; pfam13565 391626009376 Integrase core domain; Region: rve; pfam00665 391626009377 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391626009378 DctM-like transporters; Region: DctM; pfam06808 391626009379 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391626009380 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391626009381 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626009382 EamA-like transporter family; Region: EamA; pfam00892 391626009383 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391626009384 Catalytic site [active] 391626009385 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626009386 Winged helix-turn helix; Region: HTH_29; pfam13551 391626009387 Homeodomain-like domain; Region: HTH_32; pfam13565 391626009388 Integrase core domain; Region: rve; pfam00665 391626009389 Integrase core domain; Region: rve; pfam00665 391626009390 Integrase core domain; Region: rve_3; pfam13683 391626009391 Integrase core domain; Region: rve; pfam00665 391626009392 Integrase core domain; Region: rve_3; pfam13683 391626009393 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391626009394 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391626009395 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391626009396 active site 391626009397 dimer interface [polypeptide binding]; other site 391626009398 effector binding site; other site 391626009399 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391626009400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626009401 non-specific DNA binding site [nucleotide binding]; other site 391626009402 salt bridge; other site 391626009403 sequence-specific DNA binding site [nucleotide binding]; other site 391626009404 TSCPD domain; Region: TSCPD; pfam12637 391626009405 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 391626009406 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 391626009407 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 391626009408 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391626009409 active site 391626009410 dimer interface [polypeptide binding]; other site 391626009411 motif 2; other site 391626009412 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391626009413 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 391626009414 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 391626009415 dimer interface [polypeptide binding]; other site 391626009416 motif 1; other site 391626009417 motif 2; other site 391626009418 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391626009419 active site 391626009420 motif 3; other site 391626009421 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391626009422 anticodon binding site; other site 391626009423 SlyX; Region: SlyX; pfam04102 391626009424 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391626009425 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 391626009426 putative active site [active] 391626009427 putative PHP Thumb interface [polypeptide binding]; other site 391626009428 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391626009429 generic binding surface II; other site 391626009430 generic binding surface I; other site 391626009431 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391626009432 dimerization interface [polypeptide binding]; other site 391626009433 putative DNA binding site [nucleotide binding]; other site 391626009434 putative Zn2+ binding site [ion binding]; other site 391626009435 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 391626009436 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391626009437 catalytic loop [active] 391626009438 iron binding site [ion binding]; other site 391626009439 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391626009440 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391626009441 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 391626009442 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391626009443 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391626009444 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391626009445 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391626009446 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391626009447 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391626009448 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626009449 Walker A/P-loop; other site 391626009450 ATP binding site [chemical binding]; other site 391626009451 Q-loop/lid; other site 391626009452 ABC transporter signature motif; other site 391626009453 Walker B; other site 391626009454 D-loop; other site 391626009455 H-loop/switch region; other site 391626009456 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626009457 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626009458 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626009459 TM-ABC transporter signature motif; other site 391626009460 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626009461 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391626009462 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626009463 TM-ABC transporter signature motif; other site 391626009464 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391626009465 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391626009466 putative ligand binding site [chemical binding]; other site 391626009467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626009468 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626009469 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626009470 Transposase; Region: HTH_Tnp_1; cl17663 391626009471 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009472 Transposase; Region: HTH_Tnp_1; cl17663 391626009473 Amino acid synthesis; Region: AA_synth; pfam06684 391626009474 MarR family; Region: MarR_2; pfam12802 391626009475 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 391626009476 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391626009477 Walker A motif; other site 391626009478 Protein of unknown function (DUF971); Region: DUF971; pfam06155 391626009479 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 391626009480 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391626009481 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 391626009482 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626009483 DevC protein; Region: devC; TIGR01185 391626009484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391626009485 FtsX-like permease family; Region: FtsX; pfam02687 391626009486 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 391626009487 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391626009488 Walker A/P-loop; other site 391626009489 ATP binding site [chemical binding]; other site 391626009490 Q-loop/lid; other site 391626009491 ABC transporter signature motif; other site 391626009492 Walker B; other site 391626009493 D-loop; other site 391626009494 H-loop/switch region; other site 391626009495 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626009496 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626009497 Walker A/P-loop; other site 391626009498 ATP binding site [chemical binding]; other site 391626009499 Q-loop/lid; other site 391626009500 ABC transporter signature motif; other site 391626009501 Walker B; other site 391626009502 D-loop; other site 391626009503 H-loop/switch region; other site 391626009504 TOBE domain; Region: TOBE_2; pfam08402 391626009505 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626009506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009507 dimer interface [polypeptide binding]; other site 391626009508 conserved gate region; other site 391626009509 putative PBP binding loops; other site 391626009510 ABC-ATPase subunit interface; other site 391626009511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009512 dimer interface [polypeptide binding]; other site 391626009513 conserved gate region; other site 391626009514 putative PBP binding loops; other site 391626009515 ABC-ATPase subunit interface; other site 391626009516 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626009517 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626009518 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 391626009519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626009520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626009521 dimerization interface [polypeptide binding]; other site 391626009522 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391626009523 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391626009524 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 391626009525 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391626009526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391626009527 putative acyl-acceptor binding pocket; other site 391626009528 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 391626009529 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 391626009530 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 391626009531 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391626009532 ABC1 family; Region: ABC1; pfam03109 391626009533 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 391626009534 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 391626009535 metal binding site [ion binding]; metal-binding site 391626009536 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626009537 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 391626009538 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626009539 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009540 dimer interface [polypeptide binding]; other site 391626009541 conserved gate region; other site 391626009542 putative PBP binding loops; other site 391626009543 ABC-ATPase subunit interface; other site 391626009544 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626009545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009546 dimer interface [polypeptide binding]; other site 391626009547 conserved gate region; other site 391626009548 putative PBP binding loops; other site 391626009549 ABC-ATPase subunit interface; other site 391626009550 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391626009551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626009552 Walker A/P-loop; other site 391626009553 ATP binding site [chemical binding]; other site 391626009554 Q-loop/lid; other site 391626009555 ABC transporter signature motif; other site 391626009556 Walker B; other site 391626009557 D-loop; other site 391626009558 H-loop/switch region; other site 391626009559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391626009560 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626009561 Walker A/P-loop; other site 391626009562 ATP binding site [chemical binding]; other site 391626009563 Q-loop/lid; other site 391626009564 ABC transporter signature motif; other site 391626009565 Walker B; other site 391626009566 D-loop; other site 391626009567 H-loop/switch region; other site 391626009568 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391626009569 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626009570 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391626009571 NAD(P) binding site [chemical binding]; other site 391626009572 catalytic residues [active] 391626009573 catalytic residues [active] 391626009574 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391626009575 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391626009576 cleavage site 391626009577 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 391626009578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626009579 Walker A/P-loop; other site 391626009580 ATP binding site [chemical binding]; other site 391626009581 Q-loop/lid; other site 391626009582 ABC transporter signature motif; other site 391626009583 Walker B; other site 391626009584 D-loop; other site 391626009585 H-loop/switch region; other site 391626009586 TOBE domain; Region: TOBE; cl01440 391626009587 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391626009588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009589 dimer interface [polypeptide binding]; other site 391626009590 conserved gate region; other site 391626009591 putative PBP binding loops; other site 391626009592 ABC-ATPase subunit interface; other site 391626009593 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 391626009594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626009595 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391626009596 nudix motif; other site 391626009597 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 391626009598 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626009599 active site 391626009600 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 391626009601 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 391626009602 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391626009603 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391626009604 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391626009605 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 391626009606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626009607 Coenzyme A binding pocket [chemical binding]; other site 391626009608 EcsC protein family; Region: EcsC; pfam12787 391626009609 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 391626009610 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 391626009611 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391626009612 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391626009613 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391626009614 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626009615 aspartate kinase; Reviewed; Region: PRK06635 391626009616 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391626009617 putative nucleotide binding site [chemical binding]; other site 391626009618 putative catalytic residues [active] 391626009619 putative Mg ion binding site [ion binding]; other site 391626009620 putative aspartate binding site [chemical binding]; other site 391626009621 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391626009622 putative allosteric regulatory site; other site 391626009623 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391626009624 putative allosteric regulatory residue; other site 391626009625 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391626009626 FAD binding domain; Region: FAD_binding_4; pfam01565 391626009627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391626009628 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391626009629 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391626009630 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391626009631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391626009632 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 391626009633 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 391626009634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626009635 catalytic residue [active] 391626009636 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391626009637 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 391626009638 Subunit III/VIIa interface [polypeptide binding]; other site 391626009639 Phospholipid binding site [chemical binding]; other site 391626009640 Subunit I/III interface [polypeptide binding]; other site 391626009641 Subunit III/VIb interface [polypeptide binding]; other site 391626009642 Subunit III/VIa interface; other site 391626009643 Subunit III/Vb interface [polypeptide binding]; other site 391626009644 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 391626009645 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 391626009646 UbiA prenyltransferase family; Region: UbiA; pfam01040 391626009647 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 391626009648 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 391626009649 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391626009650 protease TldD; Provisional; Region: tldD; PRK10735 391626009651 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 391626009652 DNA protecting protein DprA; Region: dprA; TIGR00732 391626009653 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 391626009654 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 391626009655 active site 391626009656 interdomain interaction site; other site 391626009657 putative metal-binding site [ion binding]; other site 391626009658 nucleotide binding site [chemical binding]; other site 391626009659 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 391626009660 domain I; other site 391626009661 DNA binding groove [nucleotide binding] 391626009662 phosphate binding site [ion binding]; other site 391626009663 domain II; other site 391626009664 domain III; other site 391626009665 nucleotide binding site [chemical binding]; other site 391626009666 catalytic site [active] 391626009667 domain IV; other site 391626009668 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391626009669 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391626009670 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391626009671 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391626009672 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 391626009673 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 391626009674 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 391626009675 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 391626009676 FAD binding domain; Region: FAD_binding_4; pfam01565 391626009677 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391626009678 classical (c) SDRs; Region: SDR_c; cd05233 391626009679 NAD(P) binding site [chemical binding]; other site 391626009680 active site 391626009681 hypothetical protein; Validated; Region: PRK08238 391626009682 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391626009683 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 391626009684 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391626009685 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626009686 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626009687 catalytic residue [active] 391626009688 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626009689 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391626009690 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 391626009691 Homeodomain-like domain; Region: HTH_32; pfam13565 391626009692 Transposase; Region: HTH_Tnp_1; pfam01527 391626009693 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626009694 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 391626009695 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 391626009696 active site 391626009697 Zn binding site [ion binding]; other site 391626009698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626009699 dimer interface [polypeptide binding]; other site 391626009700 conserved gate region; other site 391626009701 putative PBP binding loops; other site 391626009702 ABC-ATPase subunit interface; other site 391626009703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391626009704 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626009705 substrate binding pocket [chemical binding]; other site 391626009706 membrane-bound complex binding site; other site 391626009707 hinge residues; other site 391626009708 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 391626009709 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391626009710 ATP binding site [chemical binding]; other site 391626009711 substrate interface [chemical binding]; other site 391626009712 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391626009713 trimer interface [polypeptide binding]; other site 391626009714 active site 391626009715 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391626009716 Flavoprotein; Region: Flavoprotein; pfam02441 391626009717 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 391626009718 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 391626009719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626009720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626009721 DNA binding residues [nucleotide binding] 391626009722 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 391626009723 homotrimer interface [polypeptide binding]; other site 391626009724 Walker A motif; other site 391626009725 GTP binding site [chemical binding]; other site 391626009726 Walker B motif; other site 391626009727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391626009728 catalytic core [active] 391626009729 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391626009730 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626009731 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 391626009732 putative substrate binding pocket (H-site) [chemical binding]; other site 391626009733 putative N-terminal domain interface [polypeptide binding]; other site 391626009734 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 391626009735 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391626009736 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626009737 Walker A motif; other site 391626009738 ATP binding site [chemical binding]; other site 391626009739 Walker B motif; other site 391626009740 arginine finger; other site 391626009741 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 391626009742 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 391626009743 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391626009744 glutathione synthetase; Provisional; Region: PRK05246 391626009745 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 391626009746 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 391626009747 Predicted methyltransferases [General function prediction only]; Region: COG0313 391626009748 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 391626009749 putative SAM binding site [chemical binding]; other site 391626009750 putative homodimer interface [polypeptide binding]; other site 391626009751 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 391626009752 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391626009753 putative ligand binding site [chemical binding]; other site 391626009754 PII uridylyl-transferase; Provisional; Region: PRK05092 391626009755 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391626009756 metal binding triad; other site 391626009757 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391626009758 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391626009759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391626009760 Zn2+ binding site [ion binding]; other site 391626009761 Mg2+ binding site [ion binding]; other site 391626009762 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 391626009763 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 391626009764 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391626009765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391626009766 ABC-ATPase subunit interface; other site 391626009767 dimer interface [polypeptide binding]; other site 391626009768 putative PBP binding regions; other site 391626009769 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 391626009770 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391626009771 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 391626009772 metal binding site 2 [ion binding]; metal-binding site 391626009773 putative DNA binding helix; other site 391626009774 metal binding site 1 [ion binding]; metal-binding site 391626009775 dimer interface [polypeptide binding]; other site 391626009776 structural Zn2+ binding site [ion binding]; other site 391626009777 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391626009778 intersubunit interface [polypeptide binding]; other site 391626009779 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391626009780 Transposase; Region: HTH_Tnp_1; cl17663 391626009781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626009782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626009783 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626009784 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391626009785 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626009786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626009787 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626009788 TM-ABC transporter signature motif; other site 391626009789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626009790 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626009791 TM-ABC transporter signature motif; other site 391626009792 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626009793 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626009794 Walker A/P-loop; other site 391626009795 ATP binding site [chemical binding]; other site 391626009796 Q-loop/lid; other site 391626009797 ABC transporter signature motif; other site 391626009798 Walker B; other site 391626009799 D-loop; other site 391626009800 H-loop/switch region; other site 391626009801 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626009802 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 391626009803 Domain of unknown function (DUF4315); Region: DUF4315; pfam14193 391626009804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391626009805 non-specific DNA binding site [nucleotide binding]; other site 391626009806 salt bridge; other site 391626009807 sequence-specific DNA binding site [nucleotide binding]; other site 391626009808 GTP-binding protein YchF; Reviewed; Region: PRK09601 391626009809 YchF GTPase; Region: YchF; cd01900 391626009810 G1 box; other site 391626009811 GTP/Mg2+ binding site [chemical binding]; other site 391626009812 Switch I region; other site 391626009813 G2 box; other site 391626009814 Switch II region; other site 391626009815 G3 box; other site 391626009816 G4 box; other site 391626009817 G5 box; other site 391626009818 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391626009819 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 391626009820 substrate binding site [chemical binding]; other site 391626009821 active site 391626009822 catalytic residues [active] 391626009823 heterodimer interface [polypeptide binding]; other site 391626009824 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626009825 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391626009826 phosphate binding site [ion binding]; other site 391626009827 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 391626009828 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 391626009829 5S rRNA interface [nucleotide binding]; other site 391626009830 CTC domain interface [polypeptide binding]; other site 391626009831 L16 interface [polypeptide binding]; other site 391626009832 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391626009833 putative active site [active] 391626009834 catalytic residue [active] 391626009835 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 391626009836 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391626009837 Beta-lactamase; Region: Beta-lactamase; pfam00144 391626009838 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 391626009839 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 391626009840 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391626009841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626009842 catalytic residue [active] 391626009843 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 391626009844 active site 391626009845 Homeobox associated leucine zipper; Region: HALZ; cl02577 391626009846 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391626009847 IHF dimer interface [polypeptide binding]; other site 391626009848 IHF - DNA interface [nucleotide binding]; other site 391626009849 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 391626009850 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391626009851 RNA binding site [nucleotide binding]; other site 391626009852 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391626009853 RNA binding site [nucleotide binding]; other site 391626009854 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 391626009855 RNA binding site [nucleotide binding]; other site 391626009856 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391626009857 RNA binding site [nucleotide binding]; other site 391626009858 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391626009859 RNA binding site [nucleotide binding]; other site 391626009860 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391626009861 RNA binding site [nucleotide binding]; other site 391626009862 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 391626009863 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 391626009864 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626009865 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626009866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 391626009867 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 391626009868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391626009869 active site residue [active] 391626009870 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391626009871 catalytic core [active] 391626009872 cytidylate kinase; Provisional; Region: cmk; PRK00023 391626009873 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391626009874 CMP-binding site; other site 391626009875 The sites determining sugar specificity; other site 391626009876 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391626009877 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391626009878 hinge; other site 391626009879 active site 391626009880 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 391626009881 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391626009882 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391626009883 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391626009884 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391626009885 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 391626009886 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391626009887 putative active site [active] 391626009888 catalytic triad [active] 391626009889 putative dimer interface [polypeptide binding]; other site 391626009890 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 391626009891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391626009892 Transporter associated domain; Region: CorC_HlyC; smart01091 391626009893 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 391626009894 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 391626009895 PhoH-like protein; Region: PhoH; pfam02562 391626009896 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626009897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626009898 ligand binding site [chemical binding]; other site 391626009899 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 391626009900 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391626009901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626009902 FeS/SAM binding site; other site 391626009903 TRAM domain; Region: TRAM; pfam01938 391626009904 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391626009905 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391626009906 metal binding site 2 [ion binding]; metal-binding site 391626009907 putative DNA binding helix; other site 391626009908 metal binding site 1 [ion binding]; metal-binding site 391626009909 dimer interface [polypeptide binding]; other site 391626009910 structural Zn2+ binding site [ion binding]; other site 391626009911 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 391626009912 active site 1 [active] 391626009913 dimer interface [polypeptide binding]; other site 391626009914 active site 2 [active] 391626009915 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 391626009916 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 391626009917 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391626009918 dimer interface [polypeptide binding]; other site 391626009919 active site 391626009920 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 391626009921 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391626009922 NAD binding site [chemical binding]; other site 391626009923 homotetramer interface [polypeptide binding]; other site 391626009924 homodimer interface [polypeptide binding]; other site 391626009925 substrate binding site [chemical binding]; other site 391626009926 active site 391626009927 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391626009928 Peptidase family M50; Region: Peptidase_M50; pfam02163 391626009929 active site 391626009930 putative substrate binding region [chemical binding]; other site 391626009931 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 391626009932 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391626009933 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 391626009934 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 391626009935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626009936 motif II; other site 391626009937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391626009938 serine racemase; Region: PLN02970 391626009939 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391626009940 tetramer interface [polypeptide binding]; other site 391626009941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626009942 catalytic residue [active] 391626009943 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626009944 putative metal binding site [ion binding]; other site 391626009945 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626009946 putative phosphate binding site [ion binding]; other site 391626009947 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391626009948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626009949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626009950 putative substrate translocation pore; other site 391626009951 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391626009952 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 391626009953 NAD binding site [chemical binding]; other site 391626009954 catalytic Zn binding site [ion binding]; other site 391626009955 substrate binding site [chemical binding]; other site 391626009956 structural Zn binding site [ion binding]; other site 391626009957 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391626009958 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391626009959 active site pocket [active] 391626009960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626009961 WHG domain; Region: WHG; pfam13305 391626009962 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391626009963 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391626009964 putative acyl-acceptor binding pocket; other site 391626009965 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 391626009966 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391626009967 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391626009968 putative catalytic site [active] 391626009969 putative metal binding site [ion binding]; other site 391626009970 putative phosphate binding site [ion binding]; other site 391626009971 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 391626009972 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 391626009973 MOFRL family; Region: MOFRL; pfam05161 391626009974 Methyltransferase domain; Region: Methyltransf_24; pfam13578 391626009975 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391626009976 TniQ; Region: TniQ; pfam06527 391626009977 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391626009978 Transposase; Region: HTH_Tnp_1; pfam01527 391626009979 HTH-like domain; Region: HTH_21; pfam13276 391626009980 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626009981 Integrase core domain; Region: rve_3; pfam13683 391626009982 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391626009983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626009984 ATP binding site [chemical binding]; other site 391626009985 putative Mg++ binding site [ion binding]; other site 391626009986 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 391626009987 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 391626009988 Integrase core domain; Region: rve; pfam00665 391626009989 Integrase core domain; Region: rve_3; pfam13683 391626009990 Helix-turn-helix domain; Region: HTH_28; pfam13518 391626009991 Winged helix-turn helix; Region: HTH_29; pfam13551 391626009992 Homeodomain-like domain; Region: HTH_32; pfam13565 391626009993 Integrase core domain; Region: rve; pfam00665 391626009994 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626009995 excinuclease ABC subunit B; Provisional; Region: PRK05298 391626009996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626009997 ATP binding site [chemical binding]; other site 391626009998 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626009999 nucleotide binding region [chemical binding]; other site 391626010000 ATP-binding site [chemical binding]; other site 391626010001 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391626010002 UvrB/uvrC motif; Region: UVR; pfam02151 391626010003 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391626010004 active site residue [active] 391626010005 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 391626010006 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 391626010007 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 391626010008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626010009 active site 391626010010 nucleotide binding site [chemical binding]; other site 391626010011 HIGH motif; other site 391626010012 KMSKS motif; other site 391626010013 tellurite resistance protein terB; Region: terB; cd07176 391626010014 putative metal binding site [ion binding]; other site 391626010015 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 391626010016 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 391626010017 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 391626010018 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391626010019 active site 391626010020 (T/H)XGH motif; other site 391626010021 PAS domain S-box; Region: sensory_box; TIGR00229 391626010022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626010023 putative active site [active] 391626010024 heme pocket [chemical binding]; other site 391626010025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391626010026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626010027 metal binding site [ion binding]; metal-binding site 391626010028 active site 391626010029 I-site; other site 391626010030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626010031 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391626010032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626010033 Walker A/P-loop; other site 391626010034 ATP binding site [chemical binding]; other site 391626010035 Q-loop/lid; other site 391626010036 ABC transporter signature motif; other site 391626010037 Walker B; other site 391626010038 D-loop; other site 391626010039 H-loop/switch region; other site 391626010040 ABC transporter; Region: ABC_tran_2; pfam12848 391626010041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391626010042 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626010043 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626010044 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626010045 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626010046 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 391626010047 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 391626010048 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 391626010049 PhnA protein; Region: PhnA; pfam03831 391626010050 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391626010051 DNA-binding site [nucleotide binding]; DNA binding site 391626010052 RNA-binding motif; other site 391626010053 Dodecin; Region: Dodecin; pfam07311 391626010054 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 391626010055 active site 391626010056 catalytic triad [active] 391626010057 oxyanion hole [active] 391626010058 switch loop; other site 391626010059 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391626010060 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 391626010061 Walker A/P-loop; other site 391626010062 ATP binding site [chemical binding]; other site 391626010063 Q-loop/lid; other site 391626010064 ABC transporter signature motif; other site 391626010065 Walker B; other site 391626010066 D-loop; other site 391626010067 H-loop/switch region; other site 391626010068 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391626010069 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391626010070 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391626010071 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 391626010072 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391626010073 HIGH motif; other site 391626010074 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391626010075 active site 391626010076 KMSKS motif; other site 391626010077 Domain of unknown function (DU1801); Region: DUF1801; cl17490 391626010078 Transposase; Region: HTH_Tnp_1; pfam01527 391626010079 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010080 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 391626010081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626010082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626010083 homodimer interface [polypeptide binding]; other site 391626010084 catalytic residue [active] 391626010085 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 391626010086 prephenate dehydrogenase; Validated; Region: PRK08507 391626010087 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 391626010088 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391626010089 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391626010090 putative active site pocket [active] 391626010091 dimerization interface [polypeptide binding]; other site 391626010092 putative catalytic residue [active] 391626010093 hypothetical protein; Validated; Region: PRK09039 391626010094 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626010095 ligand binding site [chemical binding]; other site 391626010096 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626010097 Hint domain; Region: Hint_2; pfam13403 391626010098 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409 391626010099 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626010100 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626010101 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010102 Transposase; Region: HTH_Tnp_1; cl17663 391626010103 PAS domain S-box; Region: sensory_box; TIGR00229 391626010104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391626010105 putative active site [active] 391626010106 heme pocket [chemical binding]; other site 391626010107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626010108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626010109 dimer interface [polypeptide binding]; other site 391626010110 phosphorylation site [posttranslational modification] 391626010111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626010112 ATP binding site [chemical binding]; other site 391626010113 Mg2+ binding site [ion binding]; other site 391626010114 G-X-G motif; other site 391626010115 Response regulator receiver domain; Region: Response_reg; pfam00072 391626010116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626010117 active site 391626010118 phosphorylation site [posttranslational modification] 391626010119 intermolecular recognition site; other site 391626010120 dimerization interface [polypeptide binding]; other site 391626010121 Hpt domain; Region: Hpt; pfam01627 391626010122 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391626010123 metal coordination site [ion binding]; other site 391626010124 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391626010125 active site 391626010126 tetramer interface; other site 391626010127 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391626010128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626010129 active site 391626010130 phosphorylation site [posttranslational modification] 391626010131 intermolecular recognition site; other site 391626010132 dimerization interface [polypeptide binding]; other site 391626010133 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626010134 DNA binding residues [nucleotide binding] 391626010135 dimerization interface [polypeptide binding]; other site 391626010136 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010137 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 391626010138 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626010139 putative ligand binding site [chemical binding]; other site 391626010140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626010141 acetoin reductases; Region: 23BDH; TIGR02415 391626010142 NAD(P) binding site [chemical binding]; other site 391626010143 active site 391626010144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626010145 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626010146 TM-ABC transporter signature motif; other site 391626010147 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626010148 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391626010149 TM-ABC transporter signature motif; other site 391626010150 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391626010151 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626010152 Walker A/P-loop; other site 391626010153 ATP binding site [chemical binding]; other site 391626010154 Q-loop/lid; other site 391626010155 ABC transporter signature motif; other site 391626010156 Walker B; other site 391626010157 D-loop; other site 391626010158 H-loop/switch region; other site 391626010159 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626010160 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391626010161 gamma-glutamyl kinase; Provisional; Region: PRK05429 391626010162 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391626010163 nucleotide binding site [chemical binding]; other site 391626010164 homotetrameric interface [polypeptide binding]; other site 391626010165 putative phosphate binding site [ion binding]; other site 391626010166 putative allosteric binding site; other site 391626010167 PUA domain; Region: PUA; pfam01472 391626010168 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391626010169 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391626010170 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391626010171 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391626010172 putative catalytic cysteine [active] 391626010173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010174 Protein of unknown function, DUF481; Region: DUF481; cl01213 391626010175 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 391626010176 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 391626010177 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391626010178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626010179 active site 391626010180 metal binding site [ion binding]; metal-binding site 391626010181 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391626010182 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391626010183 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391626010184 active site 391626010185 HIGH motif; other site 391626010186 dimer interface [polypeptide binding]; other site 391626010187 KMSKS motif; other site 391626010188 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391626010189 Ligand Binding Site [chemical binding]; other site 391626010190 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 391626010191 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391626010192 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391626010193 Glycoprotease family; Region: Peptidase_M22; pfam00814 391626010194 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 391626010195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626010196 Coenzyme A binding pocket [chemical binding]; other site 391626010197 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 391626010198 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391626010199 ligand binding site [chemical binding]; other site 391626010200 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391626010201 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391626010202 Walker A/P-loop; other site 391626010203 ATP binding site [chemical binding]; other site 391626010204 Q-loop/lid; other site 391626010205 ABC transporter signature motif; other site 391626010206 Walker B; other site 391626010207 D-loop; other site 391626010208 H-loop/switch region; other site 391626010209 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391626010210 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626010211 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626010212 TM-ABC transporter signature motif; other site 391626010213 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391626010214 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391626010215 TM-ABC transporter signature motif; other site 391626010216 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391626010217 purine nucleoside phosphorylase; Provisional; Region: PRK08202 391626010218 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391626010219 hypothetical protein; Provisional; Region: PRK10621 391626010220 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 391626010221 AAA domain; Region: AAA_30; pfam13604 391626010222 Family description; Region: UvrD_C_2; pfam13538 391626010223 Autoinducer synthetase; Region: Autoind_synth; cl17404 391626010224 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 391626010225 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391626010226 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391626010227 DNA binding residues [nucleotide binding] 391626010228 dimerization interface [polypeptide binding]; other site 391626010229 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 391626010230 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 391626010231 putative NAD(P) binding site [chemical binding]; other site 391626010232 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 391626010233 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391626010234 putative acyl-acceptor binding pocket; other site 391626010235 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391626010236 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391626010237 B12 binding site [chemical binding]; other site 391626010238 cobalt ligand [ion binding]; other site 391626010239 H-NS histone family; Region: Histone_HNS; pfam00816 391626010240 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391626010241 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 391626010242 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 391626010243 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 391626010244 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391626010245 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391626010246 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 391626010247 L-aspartate oxidase; Provisional; Region: PRK06175 391626010248 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391626010249 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 391626010250 putative SdhC subunit interface [polypeptide binding]; other site 391626010251 putative proximal heme binding site [chemical binding]; other site 391626010252 putative Iron-sulfur protein interface [polypeptide binding]; other site 391626010253 putative proximal quinone binding site; other site 391626010254 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 391626010255 Iron-sulfur protein interface; other site 391626010256 proximal quinone binding site [chemical binding]; other site 391626010257 SdhD (CybS) interface [polypeptide binding]; other site 391626010258 proximal heme binding site [chemical binding]; other site 391626010259 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391626010260 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391626010261 putative active site [active] 391626010262 putative catalytic site [active] 391626010263 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391626010264 active site 2 [active] 391626010265 active site 1 [active] 391626010266 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 391626010267 NnrU protein; Region: NnrU; pfam07298 391626010268 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391626010269 L-rhamnonate dehydratase; Provisional; Region: PRK15440 391626010270 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391626010271 malate dehydrogenase; Reviewed; Region: PRK06223 391626010272 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 391626010273 NAD(P) binding site [chemical binding]; other site 391626010274 dimer interface [polypeptide binding]; other site 391626010275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391626010276 substrate binding site [chemical binding]; other site 391626010277 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391626010278 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391626010279 CoA-ligase; Region: Ligase_CoA; pfam00549 391626010280 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391626010281 CoA binding domain; Region: CoA_binding; pfam02629 391626010282 CoA-ligase; Region: Ligase_CoA; pfam00549 391626010283 Protein of unknown function (DUF805); Region: DUF805; pfam05656 391626010284 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 391626010285 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 391626010286 TPP-binding site [chemical binding]; other site 391626010287 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 391626010288 dimer interface [polypeptide binding]; other site 391626010289 PYR/PP interface [polypeptide binding]; other site 391626010290 TPP binding site [chemical binding]; other site 391626010291 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626010292 E3 interaction surface; other site 391626010293 lipoyl attachment site [posttranslational modification]; other site 391626010294 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391626010295 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 391626010296 E3 interaction surface; other site 391626010297 lipoyl attachment site [posttranslational modification]; other site 391626010298 e3 binding domain; Region: E3_binding; pfam02817 391626010299 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391626010300 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 391626010301 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 391626010302 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626010303 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626010304 tellurium resistance terB-like protein; Region: terB_like; cd07177 391626010305 metal binding site [ion binding]; metal-binding site 391626010306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626010307 DNA-binding site [nucleotide binding]; DNA binding site 391626010308 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 391626010309 FCD domain; Region: FCD; pfam07729 391626010310 Protein of unknown function DUF45; Region: DUF45; pfam01863 391626010311 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 391626010312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 391626010313 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626010314 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626010315 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010316 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626010317 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626010318 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 391626010319 putative S-transferase; Provisional; Region: PRK11752 391626010320 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391626010321 C-terminal domain interface [polypeptide binding]; other site 391626010322 GSH binding site (G-site) [chemical binding]; other site 391626010323 dimer interface [polypeptide binding]; other site 391626010324 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 391626010325 dimer interface [polypeptide binding]; other site 391626010326 N-terminal domain interface [polypeptide binding]; other site 391626010327 active site 391626010328 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391626010329 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626010330 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391626010331 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 391626010332 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391626010333 choline dehydrogenase; Validated; Region: PRK02106 391626010334 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391626010335 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626010336 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391626010337 DctM-like transporters; Region: DctM; pfam06808 391626010338 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391626010339 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391626010340 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 391626010341 Bacterial transcriptional regulator; Region: IclR; pfam01614 391626010342 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 391626010343 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 391626010344 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 391626010345 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 391626010346 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626010347 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 391626010348 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 391626010349 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391626010350 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 391626010351 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 391626010352 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 391626010353 intersubunit interface [polypeptide binding]; other site 391626010354 active site 391626010355 Zn2+ binding site [ion binding]; other site 391626010356 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 391626010357 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 391626010358 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 391626010359 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391626010360 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626010361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626010362 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 391626010363 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 391626010364 homodimer interface [polypeptide binding]; other site 391626010365 active site 391626010366 FMN binding site [chemical binding]; other site 391626010367 substrate binding site [chemical binding]; other site 391626010368 4Fe-4S binding domain; Region: Fer4; cl02805 391626010369 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626010370 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626010371 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 391626010372 allantoate amidohydrolase; Reviewed; Region: PRK12893 391626010373 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391626010374 active site 391626010375 metal binding site [ion binding]; metal-binding site 391626010376 dimer interface [polypeptide binding]; other site 391626010377 phenylhydantoinase; Validated; Region: PRK08323 391626010378 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 391626010379 tetramer interface [polypeptide binding]; other site 391626010380 active site 391626010381 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391626010382 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626010383 Walker A/P-loop; other site 391626010384 ATP binding site [chemical binding]; other site 391626010385 Q-loop/lid; other site 391626010386 ABC transporter signature motif; other site 391626010387 Walker B; other site 391626010388 D-loop; other site 391626010389 H-loop/switch region; other site 391626010390 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626010391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010392 dimer interface [polypeptide binding]; other site 391626010393 conserved gate region; other site 391626010394 ABC-ATPase subunit interface; other site 391626010395 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626010396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010397 dimer interface [polypeptide binding]; other site 391626010398 conserved gate region; other site 391626010399 putative PBP binding loops; other site 391626010400 ABC-ATPase subunit interface; other site 391626010401 NMT1/THI5 like; Region: NMT1; pfam09084 391626010402 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391626010403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010404 dimer interface [polypeptide binding]; other site 391626010405 conserved gate region; other site 391626010406 ABC-ATPase subunit interface; other site 391626010407 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391626010408 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391626010409 Walker A/P-loop; other site 391626010410 ATP binding site [chemical binding]; other site 391626010411 Q-loop/lid; other site 391626010412 ABC transporter signature motif; other site 391626010413 Walker B; other site 391626010414 D-loop; other site 391626010415 H-loop/switch region; other site 391626010416 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 391626010417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626010418 substrate binding pocket [chemical binding]; other site 391626010419 membrane-bound complex binding site; other site 391626010420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626010421 DNA-binding site [nucleotide binding]; DNA binding site 391626010422 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 391626010423 UTRA domain; Region: UTRA; pfam07702 391626010424 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391626010425 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 391626010426 active site 391626010427 imidazolonepropionase; Validated; Region: PRK09356 391626010428 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 391626010429 active site 391626010430 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391626010431 active sites [active] 391626010432 tetramer interface [polypeptide binding]; other site 391626010433 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391626010434 urocanate hydratase; Provisional; Region: PRK05414 391626010435 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391626010436 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391626010437 iron-sulfur cluster [ion binding]; other site 391626010438 [2Fe-2S] cluster binding site [ion binding]; other site 391626010439 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391626010440 alpha subunit interface [polypeptide binding]; other site 391626010441 active site 391626010442 substrate binding site [chemical binding]; other site 391626010443 Fe binding site [ion binding]; other site 391626010444 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391626010445 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 391626010446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626010447 catalytic residue [active] 391626010448 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391626010449 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391626010450 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391626010451 active site 391626010452 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391626010453 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626010454 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626010455 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391626010456 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626010457 aminodeoxychorismate synthase; Provisional; Region: PRK07508 391626010458 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391626010459 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391626010460 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391626010461 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391626010462 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391626010463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391626010464 metal-binding site [ion binding] 391626010465 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391626010466 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391626010467 metal-binding site [ion binding] 391626010468 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391626010469 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391626010470 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391626010471 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 391626010472 DNA binding residues [nucleotide binding] 391626010473 dimer interface [polypeptide binding]; other site 391626010474 copper binding site [ion binding]; other site 391626010475 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391626010476 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 391626010477 UreF; Region: UreF; pfam01730 391626010478 Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371 391626010479 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 391626010480 dimer interface [polypeptide binding]; other site 391626010481 catalytic residues [active] 391626010482 urease subunit alpha; Reviewed; Region: ureC; PRK13207 391626010483 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 391626010484 subunit interactions [polypeptide binding]; other site 391626010485 active site 391626010486 flap region; other site 391626010487 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 391626010488 alpha-gamma subunit interface [polypeptide binding]; other site 391626010489 beta-gamma subunit interface [polypeptide binding]; other site 391626010490 UreD urease accessory protein; Region: UreD; pfam01774 391626010491 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 391626010492 glycine dehydrogenase; Provisional; Region: PRK05367 391626010493 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391626010494 tetramer interface [polypeptide binding]; other site 391626010495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626010496 catalytic residue [active] 391626010497 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391626010498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626010499 tetramer interface [polypeptide binding]; other site 391626010500 catalytic residue [active] 391626010501 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391626010502 lipoyl attachment site [posttranslational modification]; other site 391626010503 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 391626010504 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626010505 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 391626010506 putative chaperone; Provisional; Region: PRK11678 391626010507 nucleotide binding site [chemical binding]; other site 391626010508 putative NEF/HSP70 interaction site [polypeptide binding]; other site 391626010509 SBD interface [polypeptide binding]; other site 391626010510 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391626010511 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 391626010512 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391626010513 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391626010514 EamA-like transporter family; Region: EamA; pfam00892 391626010515 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 391626010516 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391626010517 conserved cys residue [active] 391626010518 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391626010519 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391626010520 nucleotide binding site [chemical binding]; other site 391626010521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626010522 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626010523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626010524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010525 ABC-ATPase subunit interface; other site 391626010526 putative PBP binding loops; other site 391626010527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010529 dimer interface [polypeptide binding]; other site 391626010530 conserved gate region; other site 391626010531 putative PBP binding loops; other site 391626010532 ABC-ATPase subunit interface; other site 391626010533 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391626010534 active sites [active] 391626010535 tetramer interface [polypeptide binding]; other site 391626010536 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626010537 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626010538 Walker A/P-loop; other site 391626010539 ATP binding site [chemical binding]; other site 391626010540 Q-loop/lid; other site 391626010541 ABC transporter signature motif; other site 391626010542 Walker B; other site 391626010543 D-loop; other site 391626010544 H-loop/switch region; other site 391626010545 TOBE domain; Region: TOBE_2; pfam08402 391626010546 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626010547 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391626010548 substrate binding site [chemical binding]; other site 391626010549 ATP binding site [chemical binding]; other site 391626010550 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626010551 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626010552 DNA binding site [nucleotide binding] 391626010553 domain linker motif; other site 391626010554 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 391626010555 dimerization interface [polypeptide binding]; other site 391626010556 ligand binding site [chemical binding]; other site 391626010557 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626010558 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626010559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010560 dimer interface [polypeptide binding]; other site 391626010561 conserved gate region; other site 391626010562 putative PBP binding loops; other site 391626010563 ABC-ATPase subunit interface; other site 391626010564 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010566 dimer interface [polypeptide binding]; other site 391626010567 conserved gate region; other site 391626010568 putative PBP binding loops; other site 391626010569 ABC-ATPase subunit interface; other site 391626010570 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626010571 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626010572 Walker A/P-loop; other site 391626010573 ATP binding site [chemical binding]; other site 391626010574 Q-loop/lid; other site 391626010575 ABC transporter signature motif; other site 391626010576 Walker B; other site 391626010577 D-loop; other site 391626010578 H-loop/switch region; other site 391626010579 TOBE domain; Region: TOBE_2; pfam08402 391626010580 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391626010581 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626010582 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626010583 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391626010584 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 391626010585 Metal-binding active site; metal-binding site 391626010586 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391626010587 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626010588 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626010589 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391626010590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010592 dimer interface [polypeptide binding]; other site 391626010593 conserved gate region; other site 391626010594 putative PBP binding loops; other site 391626010595 ABC-ATPase subunit interface; other site 391626010596 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391626010597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010598 dimer interface [polypeptide binding]; other site 391626010599 conserved gate region; other site 391626010600 putative PBP binding loops; other site 391626010601 ABC-ATPase subunit interface; other site 391626010602 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391626010603 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 391626010604 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391626010605 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 391626010606 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626010607 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391626010608 Walker A/P-loop; other site 391626010609 ATP binding site [chemical binding]; other site 391626010610 Q-loop/lid; other site 391626010611 ABC transporter signature motif; other site 391626010612 Walker B; other site 391626010613 D-loop; other site 391626010614 H-loop/switch region; other site 391626010615 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626010616 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391626010617 Walker A/P-loop; other site 391626010618 ATP binding site [chemical binding]; other site 391626010619 Q-loop/lid; other site 391626010620 ABC transporter signature motif; other site 391626010621 Walker B; other site 391626010622 D-loop; other site 391626010623 H-loop/switch region; other site 391626010624 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391626010625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010626 putative PBP binding loops; other site 391626010627 dimer interface [polypeptide binding]; other site 391626010628 ABC-ATPase subunit interface; other site 391626010629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010631 dimer interface [polypeptide binding]; other site 391626010632 conserved gate region; other site 391626010633 putative PBP binding loops; other site 391626010634 ABC-ATPase subunit interface; other site 391626010635 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 391626010636 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626010637 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391626010638 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 391626010639 putative active site [active] 391626010640 metal binding site [ion binding]; metal-binding site 391626010641 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 391626010642 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391626010643 gamma subunit interface [polypeptide binding]; other site 391626010644 LBP interface [polypeptide binding]; other site 391626010645 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626010646 Hint domain; Region: Hint_2; pfam13403 391626010647 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626010648 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626010649 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391626010650 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391626010651 acyl-activating enzyme (AAE) consensus motif; other site 391626010652 AMP binding site [chemical binding]; other site 391626010653 active site 391626010654 CoA binding site [chemical binding]; other site 391626010655 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391626010656 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626010657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626010658 NAD(P) binding site [chemical binding]; other site 391626010659 active site 391626010660 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391626010661 classical (c) SDRs; Region: SDR_c; cd05233 391626010662 NAD(P) binding site [chemical binding]; other site 391626010663 active site 391626010664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391626010665 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391626010666 active site 391626010667 catalytic tetrad [active] 391626010668 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626010669 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626010670 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626010671 Hint domain; Region: Hint_2; pfam13403 391626010672 Phosphotransferase enzyme family; Region: APH; pfam01636 391626010673 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626010674 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626010675 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626010676 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626010677 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 391626010678 nucleophilic elbow; other site 391626010679 catalytic triad; other site 391626010680 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391626010681 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391626010682 dimerization interface [polypeptide binding]; other site 391626010683 ligand binding site [chemical binding]; other site 391626010684 NADP binding site [chemical binding]; other site 391626010685 catalytic site [active] 391626010686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 391626010687 Bacterial SH3 domain; Region: SH3_4; pfam06347 391626010688 Bacterial SH3 domain; Region: SH3_4; pfam06347 391626010689 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 391626010690 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391626010691 FMN binding site [chemical binding]; other site 391626010692 active site 391626010693 homodimer interface [polypeptide binding]; other site 391626010694 putative catalytic residue [active] 391626010695 4Fe-4S cluster binding site [ion binding]; other site 391626010696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626010697 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 391626010698 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626010699 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391626010700 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626010701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626010702 Walker A/P-loop; other site 391626010703 ATP binding site [chemical binding]; other site 391626010704 Q-loop/lid; other site 391626010705 ABC transporter signature motif; other site 391626010706 Walker B; other site 391626010707 D-loop; other site 391626010708 H-loop/switch region; other site 391626010709 TOBE domain; Region: TOBE_2; pfam08402 391626010710 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626010711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010712 dimer interface [polypeptide binding]; other site 391626010713 conserved gate region; other site 391626010714 ABC-ATPase subunit interface; other site 391626010715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010716 dimer interface [polypeptide binding]; other site 391626010717 conserved gate region; other site 391626010718 putative PBP binding loops; other site 391626010719 ABC-ATPase subunit interface; other site 391626010720 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391626010721 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391626010722 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391626010723 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626010724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391626010725 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 391626010726 NAD(P) binding site [chemical binding]; other site 391626010727 catalytic residues [active] 391626010728 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626010729 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626010730 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626010731 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391626010732 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626010733 probable polyamine oxidase; Region: PLN02268 391626010734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626010735 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 391626010736 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391626010737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626010738 Walker A/P-loop; other site 391626010739 ATP binding site [chemical binding]; other site 391626010740 Q-loop/lid; other site 391626010741 ABC transporter signature motif; other site 391626010742 Walker B; other site 391626010743 D-loop; other site 391626010744 H-loop/switch region; other site 391626010745 TOBE domain; Region: TOBE_2; pfam08402 391626010746 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391626010747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626010748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010749 dimer interface [polypeptide binding]; other site 391626010750 conserved gate region; other site 391626010751 putative PBP binding loops; other site 391626010752 ABC-ATPase subunit interface; other site 391626010753 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391626010754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010755 dimer interface [polypeptide binding]; other site 391626010756 conserved gate region; other site 391626010757 putative PBP binding loops; other site 391626010758 ABC-ATPase subunit interface; other site 391626010759 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 391626010760 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391626010761 CutC family; Region: CutC; cl01218 391626010762 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 391626010763 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391626010764 active site 391626010765 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 391626010766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391626010767 fructokinase; Reviewed; Region: PRK09557 391626010768 nucleotide binding site [chemical binding]; other site 391626010769 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 391626010770 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391626010771 dimer interface [polypeptide binding]; other site 391626010772 active site 391626010773 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 391626010774 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391626010775 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391626010776 dimer interface [polypeptide binding]; other site 391626010777 active site 391626010778 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391626010779 dimer interface [polypeptide binding]; other site 391626010780 active site 391626010781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626010782 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626010783 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626010784 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626010785 Walker A/P-loop; other site 391626010786 ATP binding site [chemical binding]; other site 391626010787 Q-loop/lid; other site 391626010788 ABC transporter signature motif; other site 391626010789 Walker B; other site 391626010790 D-loop; other site 391626010791 H-loop/switch region; other site 391626010792 TOBE domain; Region: TOBE_2; pfam08402 391626010793 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626010794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626010795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010797 dimer interface [polypeptide binding]; other site 391626010798 conserved gate region; other site 391626010799 putative PBP binding loops; other site 391626010800 ABC-ATPase subunit interface; other site 391626010801 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391626010802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010803 dimer interface [polypeptide binding]; other site 391626010804 conserved gate region; other site 391626010805 putative PBP binding loops; other site 391626010806 ABC-ATPase subunit interface; other site 391626010807 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391626010808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391626010809 DNA-binding site [nucleotide binding]; DNA binding site 391626010810 UTRA domain; Region: UTRA; pfam07702 391626010811 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 391626010812 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 391626010813 active site 391626010814 Transposase; Region: HTH_Tnp_1; pfam01527 391626010815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391626010816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391626010817 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 391626010818 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391626010819 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 391626010820 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391626010821 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391626010822 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391626010823 HlyD family secretion protein; Region: HlyD_3; pfam13437 391626010824 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391626010825 Protein export membrane protein; Region: SecD_SecF; cl14618 391626010826 SapC; Region: SapC; pfam07277 391626010827 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391626010828 Hint domain; Region: Hint_2; pfam13403 391626010829 Transposase; Region: HTH_Tnp_1; pfam01527 391626010830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626010831 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626010832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626010833 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626010834 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 391626010835 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391626010836 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626010837 Walker A/P-loop; other site 391626010838 ATP binding site [chemical binding]; other site 391626010839 Q-loop/lid; other site 391626010840 ABC transporter signature motif; other site 391626010841 Walker B; other site 391626010842 D-loop; other site 391626010843 H-loop/switch region; other site 391626010844 TOBE domain; Region: TOBE_2; pfam08402 391626010845 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391626010846 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 391626010847 DAK2 domain; Region: Dak2; pfam02734 391626010848 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626010849 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391626010850 Walker A/P-loop; other site 391626010851 ATP binding site [chemical binding]; other site 391626010852 Q-loop/lid; other site 391626010853 ABC transporter signature motif; other site 391626010854 Walker B; other site 391626010855 D-loop; other site 391626010856 H-loop/switch region; other site 391626010857 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391626010858 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626010859 Walker A/P-loop; other site 391626010860 ATP binding site [chemical binding]; other site 391626010861 Q-loop/lid; other site 391626010862 ABC transporter signature motif; other site 391626010863 Walker B; other site 391626010864 D-loop; other site 391626010865 H-loop/switch region; other site 391626010866 TOBE domain; Region: TOBE_2; pfam08402 391626010867 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391626010868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010869 dimer interface [polypeptide binding]; other site 391626010870 conserved gate region; other site 391626010871 putative PBP binding loops; other site 391626010872 ABC-ATPase subunit interface; other site 391626010873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010874 dimer interface [polypeptide binding]; other site 391626010875 conserved gate region; other site 391626010876 ABC-ATPase subunit interface; other site 391626010877 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391626010878 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391626010879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626010880 DNA binding site [nucleotide binding] 391626010881 domain linker motif; other site 391626010882 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391626010883 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391626010884 putative ligand binding site [chemical binding]; other site 391626010885 putative transposase OrfB; Reviewed; Region: PHA02517 391626010886 HTH-like domain; Region: HTH_21; pfam13276 391626010887 Integrase core domain; Region: rve; pfam00665 391626010888 Integrase core domain; Region: rve_3; pfam13683 391626010889 Transposase; Region: HTH_Tnp_1; cl17663 391626010890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626010891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626010892 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 391626010893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626010894 ATP binding site [chemical binding]; other site 391626010895 Mg2+ binding site [ion binding]; other site 391626010896 G-X-G motif; other site 391626010897 mercuric reductase; Validated; Region: PRK06370 391626010898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626010899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626010900 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391626010901 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391626010902 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391626010903 Ribonuclease P; Region: Ribonuclease_P; pfam00825 391626010904 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 391626010905 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391626010906 metal binding site [ion binding]; metal-binding site 391626010907 active site 391626010908 I-site; other site 391626010909 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391626010910 membrane protein insertase; Provisional; Region: PRK01318 391626010911 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 391626010912 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391626010913 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391626010914 MOSC domain; Region: MOSC; pfam03473 391626010915 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 391626010916 G1 box; other site 391626010917 GTP/Mg2+ binding site [chemical binding]; other site 391626010918 Switch I region; other site 391626010919 G2 box; other site 391626010920 G3 box; other site 391626010921 Switch II region; other site 391626010922 G4 box; other site 391626010923 G5 box; other site 391626010924 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 391626010925 feedback inhibition sensing region; other site 391626010926 homohexameric interface [polypeptide binding]; other site 391626010927 nucleotide binding site [chemical binding]; other site 391626010928 N-acetyl-L-glutamate binding site [chemical binding]; other site 391626010929 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 391626010930 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391626010931 catalytic core [active] 391626010932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391626010933 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391626010934 Walker A/P-loop; other site 391626010935 ATP binding site [chemical binding]; other site 391626010936 Q-loop/lid; other site 391626010937 ABC transporter signature motif; other site 391626010938 Walker B; other site 391626010939 D-loop; other site 391626010940 H-loop/switch region; other site 391626010941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010942 dimer interface [polypeptide binding]; other site 391626010943 conserved gate region; other site 391626010944 putative PBP binding loops; other site 391626010945 ABC-ATPase subunit interface; other site 391626010946 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 391626010947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391626010948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626010949 dimer interface [polypeptide binding]; other site 391626010950 ABC-ATPase subunit interface; other site 391626010951 putative PBP binding loops; other site 391626010952 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 391626010953 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391626010954 substrate binding pocket [chemical binding]; other site 391626010955 membrane-bound complex binding site; other site 391626010956 hinge residues; other site 391626010957 ATP12 chaperone protein; Region: ATP12; cl02228 391626010958 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391626010959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391626010960 RNA binding surface [nucleotide binding]; other site 391626010961 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391626010962 active site 391626010963 camphor resistance protein CrcB; Provisional; Region: PRK14195 391626010964 recombination factor protein RarA; Reviewed; Region: PRK13342 391626010965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626010966 Walker A motif; other site 391626010967 ATP binding site [chemical binding]; other site 391626010968 Walker B motif; other site 391626010969 arginine finger; other site 391626010970 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 391626010971 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 391626010972 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391626010973 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391626010974 alphaNTD - beta interaction site [polypeptide binding]; other site 391626010975 alphaNTD homodimer interface [polypeptide binding]; other site 391626010976 alphaNTD - beta' interaction site [polypeptide binding]; other site 391626010977 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 391626010978 30S ribosomal protein S11; Validated; Region: PRK05309 391626010979 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391626010980 30S ribosomal protein S13; Region: bact_S13; TIGR03631 391626010981 adenylate kinase; Reviewed; Region: adk; PRK00279 391626010982 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391626010983 AMP-binding site [chemical binding]; other site 391626010984 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391626010985 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391626010986 SecY translocase; Region: SecY; pfam00344 391626010987 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 391626010988 threonine dehydratase; Provisional; Region: PRK07334 391626010989 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391626010990 tetramer interface [polypeptide binding]; other site 391626010991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626010992 catalytic residue [active] 391626010993 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 391626010994 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 391626010995 23S rRNA binding site [nucleotide binding]; other site 391626010996 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391626010997 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391626010998 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391626010999 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391626011000 5S rRNA interface [nucleotide binding]; other site 391626011001 L27 interface [polypeptide binding]; other site 391626011002 23S rRNA interface [nucleotide binding]; other site 391626011003 L5 interface [polypeptide binding]; other site 391626011004 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391626011005 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391626011006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391626011007 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 391626011008 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 391626011009 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391626011010 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391626011011 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391626011012 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 391626011013 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 391626011014 RNA binding site [nucleotide binding]; other site 391626011015 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 391626011016 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 391626011017 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 391626011018 putative translocon interaction site; other site 391626011019 23S rRNA interface [nucleotide binding]; other site 391626011020 signal recognition particle (SRP54) interaction site; other site 391626011021 L23 interface [polypeptide binding]; other site 391626011022 trigger factor interaction site; other site 391626011023 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 391626011024 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 391626011025 conserved hypothetical protein; Region: TIGR02466 391626011026 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 391626011027 Transposase domain (DUF772); Region: DUF772; pfam05598 391626011028 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391626011029 23S rRNA interface [nucleotide binding]; other site 391626011030 5S rRNA interface [nucleotide binding]; other site 391626011031 putative antibiotic binding site [chemical binding]; other site 391626011032 L25 interface [polypeptide binding]; other site 391626011033 L27 interface [polypeptide binding]; other site 391626011034 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391626011035 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 391626011036 G-X-X-G motif; other site 391626011037 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391626011038 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391626011039 putative translocon binding site; other site 391626011040 protein-rRNA interface [nucleotide binding]; other site 391626011041 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 391626011042 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391626011043 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391626011044 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391626011045 Transposase; Region: HTH_Tnp_1; pfam01527 391626011046 HTH-like domain; Region: HTH_21; pfam13276 391626011047 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626011048 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626011049 Integrase core domain; Region: rve_3; pfam13683 391626011050 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 391626011051 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 391626011052 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 391626011053 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 391626011054 elongation factor Tu; Reviewed; Region: PRK00049 391626011055 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391626011056 G1 box; other site 391626011057 GEF interaction site [polypeptide binding]; other site 391626011058 GTP/Mg2+ binding site [chemical binding]; other site 391626011059 Switch I region; other site 391626011060 G2 box; other site 391626011061 G3 box; other site 391626011062 Switch II region; other site 391626011063 G4 box; other site 391626011064 G5 box; other site 391626011065 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391626011066 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391626011067 Antibiotic Binding Site [chemical binding]; other site 391626011068 elongation factor G; Reviewed; Region: PRK00007 391626011069 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 391626011070 G1 box; other site 391626011071 putative GEF interaction site [polypeptide binding]; other site 391626011072 GTP/Mg2+ binding site [chemical binding]; other site 391626011073 Switch I region; other site 391626011074 G2 box; other site 391626011075 G3 box; other site 391626011076 Switch II region; other site 391626011077 G4 box; other site 391626011078 G5 box; other site 391626011079 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391626011080 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391626011081 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391626011082 30S ribosomal protein S7; Validated; Region: PRK05302 391626011083 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391626011084 S17 interaction site [polypeptide binding]; other site 391626011085 S8 interaction site; other site 391626011086 16S rRNA interaction site [nucleotide binding]; other site 391626011087 streptomycin interaction site [chemical binding]; other site 391626011088 23S rRNA interaction site [nucleotide binding]; other site 391626011089 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391626011090 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626011091 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391626011092 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 391626011093 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 391626011094 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391626011095 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391626011096 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391626011097 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 391626011098 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391626011099 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 391626011100 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391626011101 DNA binding site [nucleotide binding] 391626011102 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391626011103 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 391626011104 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391626011105 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 391626011106 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391626011107 RPB11 interaction site [polypeptide binding]; other site 391626011108 RPB12 interaction site [polypeptide binding]; other site 391626011109 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391626011110 RPB3 interaction site [polypeptide binding]; other site 391626011111 RPB1 interaction site [polypeptide binding]; other site 391626011112 RPB11 interaction site [polypeptide binding]; other site 391626011113 RPB10 interaction site [polypeptide binding]; other site 391626011114 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391626011115 core dimer interface [polypeptide binding]; other site 391626011116 peripheral dimer interface [polypeptide binding]; other site 391626011117 L10 interface [polypeptide binding]; other site 391626011118 L11 interface [polypeptide binding]; other site 391626011119 putative EF-Tu interaction site [polypeptide binding]; other site 391626011120 putative EF-G interaction site [polypeptide binding]; other site 391626011121 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 391626011122 23S rRNA interface [nucleotide binding]; other site 391626011123 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391626011124 Integrase core domain; Region: rve_3; pfam13683 391626011125 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626011126 HTH-like domain; Region: HTH_21; pfam13276 391626011127 Transposase; Region: HTH_Tnp_1; pfam01527 391626011128 Transposase; Region: HTH_Tnp_1; cl17663 391626011129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391626011130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391626011131 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626011132 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626011133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391626011134 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391626011135 Coenzyme A binding pocket [chemical binding]; other site 391626011136 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 391626011137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391626011138 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391626011139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626011140 S-adenosylmethionine binding site [chemical binding]; other site 391626011141 Transposase; Region: HTH_Tnp_1; pfam01527 391626011142 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 391626011143 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 391626011144 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 391626011145 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 391626011146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391626011147 motif II; other site 391626011148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391626011149 catalytic core [active] 391626011150 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391626011151 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391626011152 active site 391626011153 DNA binding site [nucleotide binding] 391626011154 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391626011155 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 391626011156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626011157 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391626011158 Walker A motif; other site 391626011159 ATP binding site [chemical binding]; other site 391626011160 Walker B motif; other site 391626011161 arginine finger; other site 391626011162 Peptidase family M41; Region: Peptidase_M41; pfam01434 391626011163 Hemin uptake protein hemP; Region: hemP; pfam10636 391626011164 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 391626011165 Imelysin; Region: Peptidase_M75; pfam09375 391626011166 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 391626011167 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 391626011168 Imelysin; Region: Peptidase_M75; cl09159 391626011169 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391626011170 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391626011171 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 391626011172 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 391626011173 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391626011174 dimerization interface [polypeptide binding]; other site 391626011175 DPS ferroxidase diiron center [ion binding]; other site 391626011176 ion pore; other site 391626011177 Transcriptional regulator; Region: Rrf2; cl17282 391626011178 Predicted transcriptional regulator [Transcription]; Region: COG1959 391626011179 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 391626011180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391626011181 ABC-ATPase subunit interface; other site 391626011182 dimer interface [polypeptide binding]; other site 391626011183 putative PBP binding regions; other site 391626011184 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 391626011185 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 391626011186 putative hemin binding site; other site 391626011187 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 391626011188 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 391626011189 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 391626011190 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 391626011191 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391626011192 N-terminal plug; other site 391626011193 ligand-binding site [chemical binding]; other site 391626011194 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391626011195 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 391626011196 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 391626011197 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391626011198 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391626011199 catalytic residues [active] 391626011200 catalytic nucleophile [active] 391626011201 Recombinase; Region: Recombinase; pfam07508 391626011202 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 391626011203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 391626011204 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391626011205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626011206 Walker A/P-loop; other site 391626011207 ATP binding site [chemical binding]; other site 391626011208 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391626011209 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391626011210 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391626011211 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391626011212 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391626011213 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626011214 Phospholipid methyltransferase; Region: PEMT; cl17370 391626011215 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391626011216 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626011217 S-adenosylmethionine binding site [chemical binding]; other site 391626011218 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391626011219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626011220 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391626011221 NAD(P) binding site [chemical binding]; other site 391626011222 active site 391626011223 Dihydroneopterin aldolase; Region: FolB; pfam02152 391626011224 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391626011225 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 391626011226 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626011227 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 391626011228 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 391626011229 substrate binding site [chemical binding]; other site 391626011230 multimerization interface [polypeptide binding]; other site 391626011231 ATP binding site [chemical binding]; other site 391626011232 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391626011233 thiamine phosphate binding site [chemical binding]; other site 391626011234 active site 391626011235 pyrophosphate binding site [ion binding]; other site 391626011236 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391626011237 dimer interface [polypeptide binding]; other site 391626011238 substrate binding site [chemical binding]; other site 391626011239 ATP binding site [chemical binding]; other site 391626011240 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 391626011241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626011242 NAD(P) binding site [chemical binding]; other site 391626011243 active site 391626011244 TIGR02594 family protein; Region: TIGR02594 391626011245 DNA photolyase; Region: DNA_photolyase; pfam00875 391626011246 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 391626011247 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391626011248 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391626011249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626011250 active site 391626011251 phosphorylation site [posttranslational modification] 391626011252 intermolecular recognition site; other site 391626011253 dimerization interface [polypeptide binding]; other site 391626011254 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391626011255 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391626011256 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391626011257 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 391626011258 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 391626011259 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391626011260 substrate binding pocket [chemical binding]; other site 391626011261 substrate-Mg2+ binding site; other site 391626011262 aspartate-rich region 1; other site 391626011263 aspartate-rich region 2; other site 391626011264 phytoene desaturase; Region: crtI_fam; TIGR02734 391626011265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626011266 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 391626011267 substrate binding pocket [chemical binding]; other site 391626011268 substrate-Mg2+ binding site; other site 391626011269 aspartate-rich region 1; other site 391626011270 aspartate-rich region 2; other site 391626011271 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 391626011272 lycopene cyclase; Region: lycopene_cycl; TIGR01789 391626011273 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 391626011274 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626011275 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626011276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626011277 ATP binding site [chemical binding]; other site 391626011278 putative Mg++ binding site [ion binding]; other site 391626011279 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 391626011280 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626011281 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391626011282 active site 391626011283 Int/Topo IB signature motif; other site 391626011284 DNA binding site [nucleotide binding] 391626011285 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 391626011286 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391626011287 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626011288 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626011289 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391626011290 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391626011291 active site 391626011292 catalytic residues [active] 391626011293 DNA binding site [nucleotide binding] 391626011294 Int/Topo IB signature motif; other site 391626011295 Ion transport protein; Region: Ion_trans; pfam00520 391626011296 Ion channel; Region: Ion_trans_2; pfam07885 391626011297 Winged helix-turn helix; Region: HTH_29; pfam13551 391626011298 Winged helix-turn helix; Region: HTH_33; pfam13592 391626011299 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391626011300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391626011301 Phage associated DNA primase [General function prediction only]; Region: COG3378 391626011302 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626011303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626011304 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391626011305 H-NS histone family; Region: Histone_HNS; pfam00816 391626011306 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391626011307 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391626011308 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391626011309 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391626011310 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 391626011311 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626011312 putative NAD(P) binding site [chemical binding]; other site 391626011313 active site 391626011314 Bacitracin resistance protein BacA; Region: BacA; pfam02673 391626011315 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391626011316 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391626011317 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 391626011318 active site 391626011319 dimer interface [polypeptide binding]; other site 391626011320 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391626011321 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391626011322 active site 391626011323 FMN binding site [chemical binding]; other site 391626011324 substrate binding site [chemical binding]; other site 391626011325 3Fe-4S cluster binding site [ion binding]; other site 391626011326 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391626011327 domain interface; other site 391626011328 Transglycosylase; Region: Transgly; cl17702 391626011329 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 391626011330 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391626011331 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391626011332 C-terminal domain interface [polypeptide binding]; other site 391626011333 GSH binding site (G-site) [chemical binding]; other site 391626011334 dimer interface [polypeptide binding]; other site 391626011335 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391626011336 N-terminal domain interface [polypeptide binding]; other site 391626011337 dimer interface [polypeptide binding]; other site 391626011338 substrate binding pocket (H-site) [chemical binding]; other site 391626011339 epoxyqueuosine reductase; Region: TIGR00276 391626011340 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 391626011341 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 391626011342 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 391626011343 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391626011344 EamA-like transporter family; Region: EamA; pfam00892 391626011345 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 391626011346 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391626011347 homodimer interface [polypeptide binding]; other site 391626011348 substrate-cofactor binding pocket; other site 391626011349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626011350 catalytic residue [active] 391626011351 MarR family; Region: MarR_2; pfam12802 391626011352 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391626011353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626011354 active site 391626011355 phosphorylation site [posttranslational modification] 391626011356 intermolecular recognition site; other site 391626011357 dimerization interface [polypeptide binding]; other site 391626011358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626011359 DNA binding site [nucleotide binding] 391626011360 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391626011361 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 391626011362 putative active site [active] 391626011363 Zn binding site [ion binding]; other site 391626011364 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 391626011365 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391626011366 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391626011367 substrate binding pocket [chemical binding]; other site 391626011368 chain length determination region; other site 391626011369 substrate-Mg2+ binding site; other site 391626011370 catalytic residues [active] 391626011371 aspartate-rich region 1; other site 391626011372 active site lid residues [active] 391626011373 aspartate-rich region 2; other site 391626011374 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391626011375 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391626011376 TPP-binding site; other site 391626011377 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391626011378 PYR/PP interface [polypeptide binding]; other site 391626011379 dimer interface [polypeptide binding]; other site 391626011380 TPP binding site [chemical binding]; other site 391626011381 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391626011382 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 391626011383 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626011384 putative NAD(P) binding site [chemical binding]; other site 391626011385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011386 Integrase core domain; Region: rve; pfam00665 391626011387 putative transposase OrfB; Reviewed; Region: PHA02517 391626011388 HTH-like domain; Region: HTH_21; pfam13276 391626011389 Integrase core domain; Region: rve; pfam00665 391626011390 Integrase core domain; Region: rve_3; pfam13683 391626011391 Transposase; Region: HTH_Tnp_1; pfam01527 391626011392 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391626011393 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391626011394 DNA polymerase IV; Provisional; Region: PRK02794 391626011395 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391626011396 active site 391626011397 DNA binding site [nucleotide binding] 391626011398 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 391626011399 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391626011400 Helix-turn-helix domain; Region: HTH_38; pfam13936 391626011401 Homeodomain-like domain; Region: HTH_32; pfam13565 391626011402 Integrase core domain; Region: rve; pfam00665 391626011403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391626011404 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391626011405 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626011406 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391626011407 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 391626011408 active site 391626011409 ligand binding site [chemical binding]; other site 391626011410 homodimer interface [polypeptide binding]; other site 391626011411 NAD(P) binding site [chemical binding]; other site 391626011412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626011413 short chain dehydrogenase; Provisional; Region: PRK07024 391626011414 NAD(P) binding site [chemical binding]; other site 391626011415 active site 391626011416 MFS/sugar transport protein; Region: MFS_2; pfam13347 391626011417 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 391626011418 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 391626011419 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 391626011420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391626011421 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626011422 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 391626011423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391626011424 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391626011425 DNA binding residues [nucleotide binding] 391626011426 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 391626011427 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391626011428 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 391626011429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626011430 ATP binding site [chemical binding]; other site 391626011431 Mg2+ binding site [ion binding]; other site 391626011432 G-X-G motif; other site 391626011433 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 391626011434 ATP binding site [chemical binding]; other site 391626011435 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 391626011436 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391626011437 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391626011438 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391626011439 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391626011440 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391626011441 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 391626011442 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 391626011443 lipoprotein signal peptidase; Provisional; Region: PRK14787 391626011444 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391626011445 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391626011446 purine monophosphate binding site [chemical binding]; other site 391626011447 dimer interface [polypeptide binding]; other site 391626011448 putative catalytic residues [active] 391626011449 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 391626011450 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 391626011451 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 391626011452 NusB family; Region: NusB; pfam01029 391626011453 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 391626011454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626011455 S-adenosylmethionine binding site [chemical binding]; other site 391626011456 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 391626011457 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 391626011458 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391626011459 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 391626011460 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391626011461 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 391626011462 Predicted periplasmic protein [Function unknown]; Region: COG3698 391626011463 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 391626011464 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 391626011465 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 391626011466 RNA binding site [nucleotide binding]; other site 391626011467 active site 391626011468 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391626011469 active site 391626011470 metal binding site [ion binding]; metal-binding site 391626011471 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391626011472 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 391626011473 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391626011474 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 391626011475 16S/18S rRNA binding site [nucleotide binding]; other site 391626011476 S13e-L30e interaction site [polypeptide binding]; other site 391626011477 25S rRNA binding site [nucleotide binding]; other site 391626011478 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 391626011479 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 391626011480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391626011481 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 391626011482 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 391626011483 RNase E interface [polypeptide binding]; other site 391626011484 trimer interface [polypeptide binding]; other site 391626011485 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391626011486 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 391626011487 RNase E interface [polypeptide binding]; other site 391626011488 trimer interface [polypeptide binding]; other site 391626011489 active site 391626011490 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391626011491 putative nucleic acid binding region [nucleotide binding]; other site 391626011492 G-X-X-G motif; other site 391626011493 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 391626011494 RNA binding site [nucleotide binding]; other site 391626011495 domain interface; other site 391626011496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391626011497 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391626011498 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391626011499 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391626011500 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391626011501 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391626011502 active site 391626011503 Predicted permeases [General function prediction only]; Region: RarD; COG2962 391626011504 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626011505 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626011506 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626011507 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626011508 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 391626011509 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391626011510 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391626011511 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391626011512 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391626011513 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391626011514 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391626011515 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391626011516 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391626011517 non-specific DNA binding site [nucleotide binding]; other site 391626011518 salt bridge; other site 391626011519 sequence-specific DNA binding site [nucleotide binding]; other site 391626011520 Cupin domain; Region: Cupin_2; pfam07883 391626011521 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 391626011522 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391626011523 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391626011524 catalytic site [active] 391626011525 putative active site [active] 391626011526 putative substrate binding site [chemical binding]; other site 391626011527 KpsF/GutQ family protein; Region: kpsF; TIGR00393 391626011528 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 391626011529 putative active site [active] 391626011530 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 391626011531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 391626011532 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 391626011533 OstA-like protein; Region: OstA; pfam03968 391626011534 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 391626011535 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 391626011536 Walker A/P-loop; other site 391626011537 ATP binding site [chemical binding]; other site 391626011538 Q-loop/lid; other site 391626011539 ABC transporter signature motif; other site 391626011540 Walker B; other site 391626011541 D-loop; other site 391626011542 H-loop/switch region; other site 391626011543 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 391626011544 30S subunit binding site; other site 391626011545 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391626011546 active site 391626011547 phosphorylation site [posttranslational modification] 391626011548 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391626011549 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391626011550 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391626011551 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626011552 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391626011553 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391626011554 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391626011555 active site 391626011556 tetramer interface; other site 391626011557 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 391626011558 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 391626011559 Ligand binding site; other site 391626011560 oligomer interface; other site 391626011561 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391626011562 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391626011563 active site 391626011564 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391626011565 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391626011566 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391626011567 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 391626011568 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391626011569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391626011570 nucleotide binding site [chemical binding]; other site 391626011571 chaperone protein DnaJ; Provisional; Region: PRK10767 391626011572 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391626011573 HSP70 interaction site [polypeptide binding]; other site 391626011574 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 391626011575 substrate binding site [polypeptide binding]; other site 391626011576 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391626011577 Zn binding sites [ion binding]; other site 391626011578 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391626011579 dimer interface [polypeptide binding]; other site 391626011580 hypothetical protein; Reviewed; Region: PRK00024 391626011581 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391626011582 MPN+ (JAMM) motif; other site 391626011583 Zinc-binding site [ion binding]; other site 391626011584 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391626011585 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391626011586 ligand binding site [chemical binding]; other site 391626011587 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391626011588 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391626011589 nucleotide binding region [chemical binding]; other site 391626011590 ATP-binding site [chemical binding]; other site 391626011591 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 391626011592 SEC-C motif; Region: SEC-C; pfam02810 391626011593 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 391626011594 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391626011595 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 391626011596 heterotetramer interface [polypeptide binding]; other site 391626011597 active site pocket [active] 391626011598 cleavage site 391626011599 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391626011600 active site 391626011601 8-oxo-dGMP binding site [chemical binding]; other site 391626011602 nudix motif; other site 391626011603 metal binding site [ion binding]; metal-binding site 391626011604 translation initiation factor IF-2; Region: IF-2; TIGR00487 391626011605 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391626011606 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 391626011607 G1 box; other site 391626011608 putative GEF interaction site [polypeptide binding]; other site 391626011609 GTP/Mg2+ binding site [chemical binding]; other site 391626011610 Switch I region; other site 391626011611 G2 box; other site 391626011612 G3 box; other site 391626011613 Switch II region; other site 391626011614 G4 box; other site 391626011615 G5 box; other site 391626011616 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 391626011617 Translation-initiation factor 2; Region: IF-2; pfam11987 391626011618 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 391626011619 hypothetical protein; Provisional; Region: PRK09190 391626011620 Protein of unknown function (DUF448); Region: DUF448; pfam04296 391626011621 putative RNA binding cleft [nucleotide binding]; other site 391626011622 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 391626011623 NusA N-terminal domain; Region: NusA_N; pfam08529 391626011624 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 391626011625 RNA binding site [nucleotide binding]; other site 391626011626 homodimer interface [polypeptide binding]; other site 391626011627 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391626011628 G-X-X-G motif; other site 391626011629 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391626011630 G-X-X-G motif; other site 391626011631 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391626011632 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391626011633 ribosome maturation protein RimP; Reviewed; Region: PRK00092 391626011634 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 391626011635 putative oligomer interface [polypeptide binding]; other site 391626011636 putative RNA binding site [nucleotide binding]; other site 391626011637 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391626011638 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391626011639 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391626011640 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626011641 Walker A/P-loop; other site 391626011642 ATP binding site [chemical binding]; other site 391626011643 Q-loop/lid; other site 391626011644 ABC transporter signature motif; other site 391626011645 Walker B; other site 391626011646 D-loop; other site 391626011647 H-loop/switch region; other site 391626011648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391626011649 Walker A/P-loop; other site 391626011650 ATP binding site [chemical binding]; other site 391626011651 Q-loop/lid; other site 391626011652 ABC transporter signature motif; other site 391626011653 Walker B; other site 391626011654 D-loop; other site 391626011655 H-loop/switch region; other site 391626011656 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391626011657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391626011658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626011659 dimer interface [polypeptide binding]; other site 391626011660 conserved gate region; other site 391626011661 putative PBP binding loops; other site 391626011662 ABC-ATPase subunit interface; other site 391626011663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391626011664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626011665 dimer interface [polypeptide binding]; other site 391626011666 conserved gate region; other site 391626011667 ABC-ATPase subunit interface; other site 391626011668 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 391626011669 TAP-like protein; Region: Abhydrolase_4; pfam08386 391626011670 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391626011671 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391626011672 MarR family; Region: MarR_2; pfam12802 391626011673 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391626011674 putative active site [active] 391626011675 catalytic triad [active] 391626011676 dimer interface [polypeptide binding]; other site 391626011677 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391626011678 GSH binding site [chemical binding]; other site 391626011679 catalytic residues [active] 391626011680 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 391626011681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391626011682 active site 391626011683 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391626011684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626011685 ferrochelatase; Reviewed; Region: hemH; PRK00035 391626011686 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391626011687 C-terminal domain interface [polypeptide binding]; other site 391626011688 active site 391626011689 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391626011690 active site 391626011691 N-terminal domain interface [polypeptide binding]; other site 391626011692 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391626011693 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391626011694 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 391626011695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626011696 S-adenosylmethionine binding site [chemical binding]; other site 391626011697 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391626011698 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626011699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626011700 Walker A/P-loop; other site 391626011701 ATP binding site [chemical binding]; other site 391626011702 Q-loop/lid; other site 391626011703 ABC transporter signature motif; other site 391626011704 Walker B; other site 391626011705 D-loop; other site 391626011706 H-loop/switch region; other site 391626011707 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391626011708 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391626011709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626011710 Walker A/P-loop; other site 391626011711 ATP binding site [chemical binding]; other site 391626011712 Q-loop/lid; other site 391626011713 ABC transporter signature motif; other site 391626011714 Walker B; other site 391626011715 D-loop; other site 391626011716 H-loop/switch region; other site 391626011717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011718 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626011719 Integrase core domain; Region: rve; pfam00665 391626011720 CcdB protein; Region: CcdB; cl03380 391626011721 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011722 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626011723 Integrase core domain; Region: rve; pfam00665 391626011724 argininosuccinate synthase; Provisional; Region: PRK13820 391626011725 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 391626011726 ANP binding site [chemical binding]; other site 391626011727 Substrate Binding Site II [chemical binding]; other site 391626011728 Substrate Binding Site I [chemical binding]; other site 391626011729 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 391626011730 nudix motif; other site 391626011731 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 391626011732 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 391626011733 dimerization interface [polypeptide binding]; other site 391626011734 domain crossover interface; other site 391626011735 redox-dependent activation switch; other site 391626011736 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391626011737 putative active site [active] 391626011738 putative CoA binding site [chemical binding]; other site 391626011739 nudix motif; other site 391626011740 metal binding site [ion binding]; metal-binding site 391626011741 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 391626011742 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391626011743 active site 391626011744 NTP binding site [chemical binding]; other site 391626011745 metal binding triad [ion binding]; metal-binding site 391626011746 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011747 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626011748 Integrase core domain; Region: rve; pfam00665 391626011749 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 391626011750 active site 391626011751 metal binding site [ion binding]; metal-binding site 391626011752 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 391626011753 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391626011754 ligand binding site [chemical binding]; other site 391626011755 NAD binding site [chemical binding]; other site 391626011756 dimerization interface [polypeptide binding]; other site 391626011757 catalytic site [active] 391626011758 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 391626011759 putative L-serine binding site [chemical binding]; other site 391626011760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 391626011761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391626011762 catalytic residue [active] 391626011763 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 391626011764 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391626011765 RNA/DNA hybrid binding site [nucleotide binding]; other site 391626011766 active site 391626011767 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391626011768 DNA methylase; Region: N6_N4_Mtase; pfam01555 391626011769 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 391626011770 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391626011771 NAD binding site [chemical binding]; other site 391626011772 homodimer interface [polypeptide binding]; other site 391626011773 active site 391626011774 substrate binding site [chemical binding]; other site 391626011775 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 391626011776 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391626011777 Di-iron ligands [ion binding]; other site 391626011778 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391626011779 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391626011780 minor groove reading motif; other site 391626011781 helix-hairpin-helix signature motif; other site 391626011782 substrate binding pocket [chemical binding]; other site 391626011783 active site 391626011784 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391626011785 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 391626011786 DNA binding and oxoG recognition site [nucleotide binding] 391626011787 Protein of unknown function (DUF721); Region: DUF721; pfam05258 391626011788 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391626011789 Thioredoxin; Region: Thioredoxin_4; pfam13462 391626011790 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391626011791 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391626011792 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 391626011793 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 391626011794 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 391626011795 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391626011796 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 391626011797 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391626011798 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391626011799 active site 391626011800 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391626011801 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391626011802 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391626011803 classical (c) SDRs; Region: SDR_c; cd05233 391626011804 NAD(P) binding site [chemical binding]; other site 391626011805 active site 391626011806 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391626011807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626011808 substrate binding site [chemical binding]; other site 391626011809 oxyanion hole (OAH) forming residues; other site 391626011810 trimer interface [polypeptide binding]; other site 391626011811 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391626011812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391626011813 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 391626011814 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626011815 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 391626011816 putative NAD(P) binding site [chemical binding]; other site 391626011817 active site 391626011818 putative substrate binding site [chemical binding]; other site 391626011819 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 391626011820 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391626011821 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391626011822 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391626011823 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391626011824 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391626011825 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626011826 active site 391626011827 extended (e) SDRs; Region: SDR_e; cd08946 391626011828 substrate binding site [chemical binding]; other site 391626011829 active site 391626011830 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 391626011831 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 391626011832 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 391626011833 Lipopolysaccharide-assembly; Region: LptE; pfam04390 391626011834 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 391626011835 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 391626011836 HIGH motif; other site 391626011837 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391626011838 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391626011839 active site 391626011840 KMSKS motif; other site 391626011841 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391626011842 tRNA binding surface [nucleotide binding]; other site 391626011843 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 391626011844 Gram-negative porin; Region: Porin_4; pfam13609 391626011845 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 391626011846 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391626011847 catalytic residue [active] 391626011848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 391626011849 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391626011850 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 391626011851 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 391626011852 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391626011853 dimerization interface [polypeptide binding]; other site 391626011854 active site 391626011855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391626011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626011857 active site 391626011858 phosphorylation site [posttranslational modification] 391626011859 intermolecular recognition site; other site 391626011860 dimerization interface [polypeptide binding]; other site 391626011861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391626011862 DNA binding site [nucleotide binding] 391626011863 transaminase; Validated; Region: PRK07324 391626011864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626011865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626011866 homodimer interface [polypeptide binding]; other site 391626011867 catalytic residue [active] 391626011868 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391626011869 putative catalytic site [active] 391626011870 putative phosphate binding site [ion binding]; other site 391626011871 active site 391626011872 metal binding site A [ion binding]; metal-binding site 391626011873 DNA binding site [nucleotide binding] 391626011874 putative AP binding site [nucleotide binding]; other site 391626011875 putative metal binding site B [ion binding]; other site 391626011876 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391626011877 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391626011878 catalytic residues [active] 391626011879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391626011880 TPR motif; other site 391626011881 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 391626011882 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391626011883 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 391626011884 amidase; Provisional; Region: PRK07056 391626011885 Amidase; Region: Amidase; cl11426 391626011886 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 391626011887 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391626011888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391626011889 homodimer interface [polypeptide binding]; other site 391626011890 catalytic residue [active] 391626011891 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 391626011892 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391626011893 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391626011894 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 391626011895 putative cation:proton antiport protein; Provisional; Region: PRK10669 391626011896 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391626011897 TrkA-N domain; Region: TrkA_N; pfam02254 391626011898 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 391626011899 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 391626011900 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391626011901 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391626011902 catalytic residue [active] 391626011903 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 391626011904 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 391626011905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011906 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626011907 Integrase core domain; Region: rve; pfam00665 391626011908 HemY protein N-terminus; Region: HemY_N; pfam07219 391626011909 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 391626011910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 391626011911 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 391626011912 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391626011913 active site 391626011914 UGMP family protein; Validated; Region: PRK09604 391626011915 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 391626011916 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391626011917 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391626011918 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391626011919 YciI-like protein; Reviewed; Region: PRK12863 391626011920 EVE domain; Region: EVE; pfam01878 391626011921 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 391626011922 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 391626011923 active site 391626011924 Zn binding site [ion binding]; other site 391626011925 hypothetical protein; Provisional; Region: PRK09256 391626011926 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 391626011927 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 391626011928 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 391626011929 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391626011930 active site 391626011931 YGGT family; Region: YGGT; pfam02325 391626011932 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 391626011933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626011934 ATP binding site [chemical binding]; other site 391626011935 putative Mg++ binding site [ion binding]; other site 391626011936 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391626011937 nucleotide binding region [chemical binding]; other site 391626011938 ATP-binding site [chemical binding]; other site 391626011939 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 391626011940 HRDC domain; Region: HRDC; pfam00570 391626011941 hypothetical protein; Validated; Region: PRK02101 391626011942 beta-ketothiolase; Provisional; Region: PRK09051 391626011943 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391626011944 dimer interface [polypeptide binding]; other site 391626011945 active site 391626011946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391626011947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391626011948 Walker A/P-loop; other site 391626011949 ATP binding site [chemical binding]; other site 391626011950 Q-loop/lid; other site 391626011951 ABC transporter signature motif; other site 391626011952 Walker B; other site 391626011953 D-loop; other site 391626011954 H-loop/switch region; other site 391626011955 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391626011956 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 391626011957 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 391626011958 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 391626011959 selenium donor protein; Region: selD; TIGR00476 391626011960 dimerization interface [polypeptide binding]; other site 391626011961 putative ATP binding site [chemical binding]; other site 391626011962 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391626011963 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 391626011964 active site residue [active] 391626011965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391626011966 Coenzyme A binding pocket [chemical binding]; other site 391626011967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626011968 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626011969 Integrase core domain; Region: rve; pfam00665 391626011970 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 391626011971 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391626011972 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391626011973 substrate binding site [chemical binding]; other site 391626011974 dimer interface [polypeptide binding]; other site 391626011975 ATP binding site [chemical binding]; other site 391626011976 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 391626011977 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391626011978 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391626011979 putative NAD(P) binding site [chemical binding]; other site 391626011980 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391626011981 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 391626011982 MutS domain I; Region: MutS_I; pfam01624 391626011983 MutS domain II; Region: MutS_II; pfam05188 391626011984 MutS domain III; Region: MutS_III; pfam05192 391626011985 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 391626011986 Walker A/P-loop; other site 391626011987 ATP binding site [chemical binding]; other site 391626011988 Q-loop/lid; other site 391626011989 ABC transporter signature motif; other site 391626011990 Walker B; other site 391626011991 D-loop; other site 391626011992 H-loop/switch region; other site 391626011993 GrpE; Region: GrpE; pfam01025 391626011994 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 391626011995 dimer interface [polypeptide binding]; other site 391626011996 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391626011997 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391626011998 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 391626011999 ribonuclease PH; Reviewed; Region: rph; PRK00173 391626012000 Ribonuclease PH; Region: RNase_PH_bact; cd11362 391626012001 hexamer interface [polypeptide binding]; other site 391626012002 active site 391626012003 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 391626012004 active site 391626012005 dimerization interface [polypeptide binding]; other site 391626012006 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 391626012007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391626012008 FeS/SAM binding site; other site 391626012009 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391626012010 ParB-like nuclease domain; Region: ParB; smart00470 391626012011 KorB domain; Region: KorB; pfam08535 391626012012 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391626012013 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391626012014 P-loop; other site 391626012015 Magnesium ion binding site [ion binding]; other site 391626012016 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391626012017 Magnesium ion binding site [ion binding]; other site 391626012018 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 391626012019 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 391626012020 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 391626012021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391626012022 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391626012023 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 391626012024 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 391626012025 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 391626012026 trmE is a tRNA modification GTPase; Region: trmE; cd04164 391626012027 G1 box; other site 391626012028 GTP/Mg2+ binding site [chemical binding]; other site 391626012029 Switch I region; other site 391626012030 G2 box; other site 391626012031 Switch II region; other site 391626012032 G3 box; other site 391626012033 G4 box; other site 391626012034 G5 box; other site 391626012035 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 391626012036 transcription termination factor Rho; Provisional; Region: rho; PRK09376 391626012037 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 391626012038 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 391626012039 RNA binding site [nucleotide binding]; other site 391626012040 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 391626012041 multimer interface [polypeptide binding]; other site 391626012042 Walker A motif; other site 391626012043 ATP binding site [chemical binding]; other site 391626012044 Walker B motif; other site 391626012045 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391626012046 active site 391626012047 dimer interface [polypeptide binding]; other site 391626012048 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391626012049 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391626012050 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391626012051 shikimate binding site; other site 391626012052 NAD(P) binding site [chemical binding]; other site 391626012053 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 391626012054 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391626012055 ATP-binding [chemical binding]; other site 391626012056 CoA-binding site [chemical binding]; other site 391626012057 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 391626012058 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 391626012059 active site 391626012060 catalytic site [active] 391626012061 substrate binding site [chemical binding]; other site 391626012062 Preprotein translocase subunit SecB; Region: SecB; pfam02556 391626012063 SecA binding site; other site 391626012064 Preprotein binding site; other site 391626012065 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 391626012066 Tim44-like domain; Region: Tim44; pfam04280 391626012067 MltA specific insert domain; Region: MltA; smart00925 391626012068 3D domain; Region: 3D; pfam06725 391626012069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 391626012070 Smr domain; Region: Smr; pfam01713 391626012071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391626012072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391626012073 putative substrate translocation pore; other site 391626012074 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 391626012075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626012076 Walker A motif; other site 391626012077 ATP binding site [chemical binding]; other site 391626012078 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 391626012079 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391626012080 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 391626012081 active site 391626012082 HslU subunit interaction site [polypeptide binding]; other site 391626012083 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391626012084 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391626012085 catalytic residues [active] 391626012086 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 391626012087 Part of AAA domain; Region: AAA_19; pfam13245 391626012088 Family description; Region: UvrD_C_2; pfam13538 391626012089 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391626012090 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 391626012091 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391626012092 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391626012093 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 391626012094 Substrate binding site; other site 391626012095 metal-binding site 391626012096 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 391626012097 Phosphotransferase enzyme family; Region: APH; pfam01636 391626012098 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 391626012099 PAS fold; Region: PAS_7; pfam12860 391626012100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391626012101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391626012102 dimer interface [polypeptide binding]; other site 391626012103 phosphorylation site [posttranslational modification] 391626012104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391626012105 ATP binding site [chemical binding]; other site 391626012106 Mg2+ binding site [ion binding]; other site 391626012107 G-X-G motif; other site 391626012108 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391626012109 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391626012110 Cu(I) binding site [ion binding]; other site 391626012111 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391626012112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391626012113 active site 391626012114 phosphorylation site [posttranslational modification] 391626012115 intermolecular recognition site; other site 391626012116 dimerization interface [polypeptide binding]; other site 391626012117 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391626012118 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391626012119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391626012120 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391626012121 dimerization interface [polypeptide binding]; other site 391626012122 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 391626012123 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391626012124 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391626012125 homotetramer interface [polypeptide binding]; other site 391626012126 ligand binding site [chemical binding]; other site 391626012127 catalytic site [active] 391626012128 NAD binding site [chemical binding]; other site 391626012129 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 391626012130 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391626012131 Integrase core domain; Region: rve; pfam00665 391626012132 Transposase; Region: HTH_Tnp_1; pfam01527 391626012133 putative transposase OrfB; Reviewed; Region: PHA02517 391626012134 HTH-like domain; Region: HTH_21; pfam13276 391626012135 Integrase core domain; Region: rve; pfam00665 391626012136 Integrase core domain; Region: rve_3; pfam13683 391626012137 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 391626012138 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391626012139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391626012140 ATP binding site [chemical binding]; other site 391626012141 putative Mg++ binding site [ion binding]; other site 391626012142 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391626012143 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391626012144 Integrase core domain; Region: rve; pfam00665 391626012145 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 391626012146 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 391626012147 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 391626012148 active site 391626012149 metal binding site [ion binding]; metal-binding site 391626012150 nudix motif; other site 391626012151 Cytochrome c; Region: Cytochrom_C; cl11414 391626012152 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 391626012153 hypothetical protein; Provisional; Region: PRK11622 391626012154 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 391626012155 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 391626012156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391626012157 putative PBP binding loops; other site 391626012158 ABC-ATPase subunit interface; other site 391626012159 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 391626012160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391626012161 Walker A/P-loop; other site 391626012162 ATP binding site [chemical binding]; other site 391626012163 Q-loop/lid; other site 391626012164 ABC transporter signature motif; other site 391626012165 Walker B; other site 391626012166 D-loop; other site 391626012167 H-loop/switch region; other site 391626012168 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391626012169 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391626012170 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391626012171 methionine sulfoxide reductase A; Provisional; Region: PRK14054 391626012172 methionine sulfoxide reductase B; Provisional; Region: PRK00222 391626012173 SelR domain; Region: SelR; pfam01641 391626012174 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391626012175 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391626012176 phosphate binding site [ion binding]; other site 391626012177 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 391626012178 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 391626012179 TPP-binding site; other site 391626012180 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391626012181 PYR/PP interface [polypeptide binding]; other site 391626012182 dimer interface [polypeptide binding]; other site 391626012183 TPP binding site [chemical binding]; other site 391626012184 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391626012185 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391626012186 NAD(P) binding site [chemical binding]; other site 391626012187 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391626012188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391626012189 NAD(P) binding site [chemical binding]; other site 391626012190 active site 391626012191 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391626012192 histidinol dehydrogenase; Region: hisD; TIGR00069 391626012193 NAD binding site [chemical binding]; other site 391626012194 dimerization interface [polypeptide binding]; other site 391626012195 product binding site; other site 391626012196 substrate binding site [chemical binding]; other site 391626012197 zinc binding site [ion binding]; other site 391626012198 catalytic residues [active] 391626012199 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391626012200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391626012201 DNA binding site [nucleotide binding] 391626012202 domain linker motif; other site 391626012203 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391626012204 putative dimerization interface [polypeptide binding]; other site 391626012205 putative ligand binding site [chemical binding]; other site 391626012206 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391626012207 Transposase; Region: HTH_Tnp_1; pfam01527 391626012208 HTH-like domain; Region: HTH_21; pfam13276 391626012209 Integrase core domain; Region: rve; pfam00665 391626012210 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391626012211 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391626012212 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391626012213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391626012214 Integrase core domain; Region: rve_3; pfam13683 391626012215 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391626012216 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391626012217 dihydroxy-acid dehydratase; Validated; Region: PRK06131 391626012218 TPR repeat; Region: TPR_11; pfam13414 391626012219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391626012220 TPR motif; other site 391626012221 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391626012222 binding surface 391626012223 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 391626012224 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 391626012225 flagellar motor protein MotB; Validated; Region: motB; PRK09041 391626012226 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 391626012227 OmpA family; Region: OmpA; pfam00691 391626012228 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 391626012229 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391626012230 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391626012231 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391626012232 transposase/IS protein; Provisional; Region: PRK09183 391626012233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391626012234 Walker A motif; other site 391626012235 ATP binding site [chemical binding]; other site 391626012236 Walker B motif; other site 391626012237 arginine finger; other site 391626012238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391626012239 Integrase core domain; Region: rve; pfam00665 391626012240 Rod binding protein; Region: Rod-binding; pfam10135 391626012241 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391626012242 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 391626012243 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391626012244 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391626012245 ABC1 family; Region: ABC1; cl17513 391626012246 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 391626012247 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 391626012248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391626012249 S-adenosylmethionine binding site [chemical binding]; other site 391626012250 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391626012251 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391626012252 DNA binding site [nucleotide binding] 391626012253 catalytic residue [active] 391626012254 H2TH interface [polypeptide binding]; other site 391626012255 putative catalytic residues [active] 391626012256 turnover-facilitating residue; other site 391626012257 intercalation triad [nucleotide binding]; other site 391626012258 8OG recognition residue [nucleotide binding]; other site 391626012259 putative reading head residues; other site 391626012260 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391626012261 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391626012262 enoyl-CoA hydratase; Provisional; Region: PRK05862 391626012263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391626012264 substrate binding site [chemical binding]; other site 391626012265 oxyanion hole (OAH) forming residues; other site 391626012266 trimer interface [polypeptide binding]; other site 391626012267 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239