-- dump date 20140619_223840 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391616000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 391616000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 391616000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616000004 Walker A motif; other site 391616000005 ATP binding site [chemical binding]; other site 391616000006 Walker B motif; other site 391616000007 arginine finger; other site 391616000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391616000009 DnaA box-binding interface [nucleotide binding]; other site 391616000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 391616000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391616000012 putative DNA binding surface [nucleotide binding]; other site 391616000013 dimer interface [polypeptide binding]; other site 391616000014 beta-clamp/clamp loader binding surface; other site 391616000015 beta-clamp/translesion DNA polymerase binding surface; other site 391616000016 recombination protein F; Reviewed; Region: recF; PRK00064 391616000017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616000018 Walker A/P-loop; other site 391616000019 ATP binding site [chemical binding]; other site 391616000020 Q-loop/lid; other site 391616000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616000022 ABC transporter signature motif; other site 391616000023 Walker B; other site 391616000024 D-loop; other site 391616000025 H-loop/switch region; other site 391616000026 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 391616000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616000028 ATP binding site [chemical binding]; other site 391616000029 Mg2+ binding site [ion binding]; other site 391616000030 G-X-G motif; other site 391616000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391616000032 anchoring element; other site 391616000033 dimer interface [polypeptide binding]; other site 391616000034 ATP binding site [chemical binding]; other site 391616000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391616000036 active site 391616000037 putative metal-binding site [ion binding]; other site 391616000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391616000039 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616000040 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391616000041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616000042 catalytic residue [active] 391616000043 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 391616000044 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 391616000045 active site residue [active] 391616000046 Isochorismatase family; Region: Isochorismatase; pfam00857 391616000047 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391616000048 catalytic triad [active] 391616000049 metal binding site [ion binding]; metal-binding site 391616000050 conserved cis-peptide bond; other site 391616000051 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391616000052 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616000053 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391616000054 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391616000055 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616000056 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616000057 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616000058 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 391616000059 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 391616000060 active site 391616000061 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 391616000062 hypothetical protein; Provisional; Region: PRK09256 391616000063 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 391616000064 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 391616000065 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 391616000066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391616000067 active site 391616000068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616000069 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616000070 YGGT family; Region: YGGT; pfam02325 391616000071 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 391616000072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616000073 ATP binding site [chemical binding]; other site 391616000074 putative Mg++ binding site [ion binding]; other site 391616000075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616000076 nucleotide binding region [chemical binding]; other site 391616000077 ATP-binding site [chemical binding]; other site 391616000078 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 391616000079 HRDC domain; Region: HRDC; pfam00570 391616000080 hypothetical protein; Validated; Region: PRK02101 391616000081 beta-ketothiolase; Provisional; Region: PRK09051 391616000082 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391616000083 dimer interface [polypeptide binding]; other site 391616000084 active site 391616000085 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391616000086 Walker A/P-loop; other site 391616000087 ATP binding site [chemical binding]; other site 391616000088 ABC transporter; Region: ABC_tran; pfam00005 391616000089 Q-loop/lid; other site 391616000090 ABC transporter signature motif; other site 391616000091 Walker B; other site 391616000092 D-loop; other site 391616000093 H-loop/switch region; other site 391616000094 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391616000095 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 391616000096 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 391616000097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616000098 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 391616000099 dimerization interface [polypeptide binding]; other site 391616000100 putative ATP binding site [chemical binding]; other site 391616000101 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616000102 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 391616000103 active site residue [active] 391616000104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616000105 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 391616000106 active site 391616000107 metal binding site [ion binding]; metal-binding site 391616000108 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 391616000109 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391616000110 ligand binding site [chemical binding]; other site 391616000111 NAD binding site [chemical binding]; other site 391616000112 dimerization interface [polypeptide binding]; other site 391616000113 catalytic site [active] 391616000114 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 391616000115 putative L-serine binding site [chemical binding]; other site 391616000116 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 391616000117 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616000118 catalytic residue [active] 391616000119 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616000120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616000121 dimer interface [polypeptide binding]; other site 391616000122 conserved gate region; other site 391616000123 putative PBP binding loops; other site 391616000124 ABC-ATPase subunit interface; other site 391616000125 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391616000126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616000127 dimer interface [polypeptide binding]; other site 391616000128 conserved gate region; other site 391616000129 putative PBP binding loops; other site 391616000130 ABC-ATPase subunit interface; other site 391616000131 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391616000132 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 391616000133 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391616000134 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 391616000135 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616000136 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391616000137 Walker A/P-loop; other site 391616000138 ATP binding site [chemical binding]; other site 391616000139 Q-loop/lid; other site 391616000140 ABC transporter signature motif; other site 391616000141 Walker B; other site 391616000142 D-loop; other site 391616000143 H-loop/switch region; other site 391616000144 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616000145 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391616000146 Walker A/P-loop; other site 391616000147 ATP binding site [chemical binding]; other site 391616000148 Q-loop/lid; other site 391616000149 ABC transporter signature motif; other site 391616000150 Walker B; other site 391616000151 D-loop; other site 391616000152 H-loop/switch region; other site 391616000153 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391616000154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616000155 dimer interface [polypeptide binding]; other site 391616000156 conserved gate region; other site 391616000157 putative PBP binding loops; other site 391616000158 ABC-ATPase subunit interface; other site 391616000159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616000160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616000161 dimer interface [polypeptide binding]; other site 391616000162 conserved gate region; other site 391616000163 putative PBP binding loops; other site 391616000164 ABC-ATPase subunit interface; other site 391616000165 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616000166 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 391616000167 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 391616000168 N- and C-terminal domain interface [polypeptide binding]; other site 391616000169 active site 391616000170 MgATP binding site [chemical binding]; other site 391616000171 catalytic site [active] 391616000172 metal binding site [ion binding]; metal-binding site 391616000173 glycerol binding site [chemical binding]; other site 391616000174 homotetramer interface [polypeptide binding]; other site 391616000175 homodimer interface [polypeptide binding]; other site 391616000176 FBP binding site [chemical binding]; other site 391616000177 protein IIAGlc interface [polypeptide binding]; other site 391616000178 fructose-1,6-bisphosphatase family protein; Region: PLN02628 391616000179 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 391616000180 AMP binding site [chemical binding]; other site 391616000181 metal binding site [ion binding]; metal-binding site 391616000182 active site 391616000183 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 391616000184 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391616000185 intersubunit interface [polypeptide binding]; other site 391616000186 active site 391616000187 zinc binding site [ion binding]; other site 391616000188 Na+ binding site [ion binding]; other site 391616000189 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 391616000190 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 391616000191 putative active site [active] 391616000192 metal binding site [ion binding]; metal-binding site 391616000193 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391616000194 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616000195 motif II; other site 391616000196 L-asparaginase II; Region: Asparaginase_II; pfam06089 391616000197 Invasion associated locus B (IalB) protein; Region: IalB; cl02207 391616000198 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 391616000199 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616000200 FeS/SAM binding site; other site 391616000201 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 391616000202 threonine dehydratase; Provisional; Region: PRK08246 391616000203 hypothetical protein; Provisional; Region: PRK06815 391616000204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616000205 catalytic residue [active] 391616000206 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 391616000207 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 391616000208 trimer interface [polypeptide binding]; other site 391616000209 active site 391616000210 substrate binding site [chemical binding]; other site 391616000211 CoA binding site [chemical binding]; other site 391616000212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616000213 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616000214 membrane-bound complex binding site; other site 391616000215 hinge residues; other site 391616000216 Integrase core domain; Region: rve; pfam00665 391616000217 Integrase core domain; Region: rve_3; pfam13683 391616000218 Hint domain; Region: Hint_2; pfam13403 391616000219 Hint domain; Region: Hint_2; pfam13403 391616000220 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 391616000221 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 391616000222 metal binding site [ion binding]; metal-binding site 391616000223 dimer interface [polypeptide binding]; other site 391616000224 ribonuclease R; Region: RNase_R; TIGR02063 391616000225 RNB domain; Region: RNB; pfam00773 391616000226 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 391616000227 RNA binding site [nucleotide binding]; other site 391616000228 Winged helix-turn helix; Region: HTH_29; pfam13551 391616000229 Homeodomain-like domain; Region: HTH_32; pfam13565 391616000230 Winged helix-turn helix; Region: HTH_33; pfam13592 391616000231 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616000232 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 391616000233 putative active site [active] 391616000234 Ap4A binding site [chemical binding]; other site 391616000235 nudix motif; other site 391616000236 putative metal binding site [ion binding]; other site 391616000237 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 391616000238 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 391616000239 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 391616000240 protein binding site [polypeptide binding]; other site 391616000241 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 391616000242 Catalytic dyad [active] 391616000243 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 391616000244 Peptidase family M23; Region: Peptidase_M23; pfam01551 391616000245 phosphoglyceromutase; Provisional; Region: PRK05434 391616000246 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 391616000247 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 391616000248 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 391616000249 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391616000250 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391616000251 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391616000252 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391616000253 substrate binding site [chemical binding]; other site 391616000254 ligand binding site [chemical binding]; other site 391616000255 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391616000256 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391616000257 substrate binding site [chemical binding]; other site 391616000258 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616000259 Integrase core domain; Region: rve; pfam00665 391616000260 Integrase core domain; Region: rve_3; pfam13683 391616000261 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391616000262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616000263 NAD(P) binding site [chemical binding]; other site 391616000264 active site 391616000265 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616000266 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616000267 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391616000268 dimerization interface [polypeptide binding]; other site 391616000269 tartrate dehydrogenase; Region: TTC; TIGR02089 391616000270 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 391616000271 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616000272 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616000273 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391616000274 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391616000275 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391616000276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616000277 dimer interface [polypeptide binding]; other site 391616000278 conserved gate region; other site 391616000279 putative PBP binding loops; other site 391616000280 ABC-ATPase subunit interface; other site 391616000281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616000282 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391616000283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391616000284 metal-binding site [ion binding] 391616000285 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391616000286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616000287 motif I; other site 391616000288 motif II; other site 391616000289 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 391616000290 FixH; Region: FixH; pfam05751 391616000291 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 391616000292 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391616000293 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 391616000294 Transposase; Region: HTH_Tnp_1; pfam01527 391616000295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616000296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616000297 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616000298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616000299 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616000300 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616000301 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616000302 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 391616000303 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 391616000304 Cytochrome c; Region: Cytochrom_C; pfam00034 391616000305 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 391616000306 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 391616000307 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 391616000308 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391616000309 Ligand Binding Site [chemical binding]; other site 391616000310 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391616000311 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391616000312 ligand binding site [chemical binding]; other site 391616000313 flexible hinge region; other site 391616000314 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391616000315 putative switch regulator; other site 391616000316 non-specific DNA interactions [nucleotide binding]; other site 391616000317 DNA binding site [nucleotide binding] 391616000318 sequence specific DNA binding site [nucleotide binding]; other site 391616000319 putative cAMP binding site [chemical binding]; other site 391616000320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616000321 putative substrate translocation pore; other site 391616000322 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391616000323 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391616000324 Domain of unknown function (DUF897); Region: DUF897; pfam05982 391616000325 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 391616000326 active site clefts [active] 391616000327 zinc binding site [ion binding]; other site 391616000328 dimer interface [polypeptide binding]; other site 391616000329 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 391616000330 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391616000331 interface (dimer of trimers) [polypeptide binding]; other site 391616000332 Substrate-binding/catalytic site; other site 391616000333 Zn-binding sites [ion binding]; other site 391616000334 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391616000335 NlpC/P60 family; Region: NLPC_P60; cl17555 391616000336 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 391616000337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616000338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616000339 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 391616000340 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 391616000341 diiron binding motif [ion binding]; other site 391616000342 Uncharacterized conserved protein [Function unknown]; Region: COG1633 391616000343 CCC1-related protein family; Region: CCC1_like_1; cd02437 391616000344 Predicted permeases [General function prediction only]; Region: COG0679 391616000345 Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers; Region: iodotyrosine_dehalogenase; cd02144 391616000346 putative FMN binding site [chemical binding]; other site 391616000347 putative dimer interface [polypeptide binding]; other site 391616000348 S-formylglutathione hydrolase; Region: PLN02442 391616000349 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 391616000350 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 391616000351 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 391616000352 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 391616000353 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391616000354 Predicted ATPase [General function prediction only]; Region: COG1485 391616000355 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616000356 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 391616000357 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 391616000358 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 391616000359 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391616000360 CAAX protease self-immunity; Region: Abi; pfam02517 391616000361 Uncharacterized conserved protein [Function unknown]; Region: COG3603 391616000362 Family description; Region: ACT_7; pfam13840 391616000363 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 391616000364 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391616000365 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 391616000366 active site 391616000367 FMN binding site [chemical binding]; other site 391616000368 2,4-decadienoyl-CoA binding site; other site 391616000369 catalytic residue [active] 391616000370 4Fe-4S cluster binding site [ion binding]; other site 391616000371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616000372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616000373 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616000374 putative effector binding pocket; other site 391616000375 dimerization interface [polypeptide binding]; other site 391616000376 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391616000377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616000378 ligand binding site [chemical binding]; other site 391616000379 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391616000380 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391616000381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616000382 Coenzyme A binding pocket [chemical binding]; other site 391616000383 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 391616000384 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 391616000385 putative MPT binding site; other site 391616000386 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 391616000387 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391616000388 active site 391616000389 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391616000390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616000391 motif II; other site 391616000392 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 391616000393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616000394 S-adenosylmethionine binding site [chemical binding]; other site 391616000395 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391616000396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616000397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616000398 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391616000399 catalytic triad [active] 391616000400 dimer interface [polypeptide binding]; other site 391616000401 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 391616000402 aromatic arch; other site 391616000403 DCoH dimer interaction site [polypeptide binding]; other site 391616000404 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391616000405 DCoH tetramer interaction site [polypeptide binding]; other site 391616000406 substrate binding site [chemical binding]; other site 391616000407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 391616000408 Protein of unknown function, DUF482; Region: DUF482; pfam04339 391616000409 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391616000410 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391616000411 active site 391616000412 catalytic site [active] 391616000413 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391616000414 homotrimer interaction site [polypeptide binding]; other site 391616000415 putative active site [active] 391616000416 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391616000417 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616000418 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391616000419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616000420 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 391616000421 Walker A/P-loop; other site 391616000422 ATP binding site [chemical binding]; other site 391616000423 Q-loop/lid; other site 391616000424 ABC transporter signature motif; other site 391616000425 Walker B; other site 391616000426 D-loop; other site 391616000427 H-loop/switch region; other site 391616000428 VacJ like lipoprotein; Region: VacJ; cl01073 391616000429 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 391616000430 Transglycosylase; Region: Transgly; pfam00912 391616000431 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391616000432 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391616000433 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 391616000434 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391616000435 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 391616000436 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391616000437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616000438 NAD(P) binding site [chemical binding]; other site 391616000439 active site 391616000440 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 391616000441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616000442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616000443 homodimer interface [polypeptide binding]; other site 391616000444 catalytic residue [active] 391616000445 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391616000446 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391616000447 active site residue [active] 391616000448 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391616000449 active site residue [active] 391616000450 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391616000451 SmpB-tmRNA interface; other site 391616000452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 391616000453 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 391616000454 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391616000455 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391616000456 dimer interface [polypeptide binding]; other site 391616000457 active site 391616000458 catalytic residue [active] 391616000459 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391616000460 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616000461 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616000462 catalytic residue [active] 391616000463 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616000464 EamA-like transporter family; Region: EamA; pfam00892 391616000465 Uncharacterized conserved protein [Function unknown]; Region: COG4121 391616000466 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616000467 Uncharacterized conserved protein [Function unknown]; Region: COG3777 391616000468 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391616000469 active site 2 [active] 391616000470 active site 1 [active] 391616000471 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391616000472 Predicted flavoprotein [General function prediction only]; Region: COG0431 391616000473 thiamine pyrophosphate protein; Validated; Region: PRK08199 391616000474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616000475 PYR/PP interface [polypeptide binding]; other site 391616000476 dimer interface [polypeptide binding]; other site 391616000477 TPP binding site [chemical binding]; other site 391616000478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391616000479 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391616000480 TPP-binding site [chemical binding]; other site 391616000481 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 391616000482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616000483 inhibitor-cofactor binding pocket; inhibition site 391616000484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616000485 catalytic residue [active] 391616000486 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391616000487 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391616000488 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 391616000489 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 391616000490 Cl binding site [ion binding]; other site 391616000491 oligomer interface [polypeptide binding]; other site 391616000492 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391616000493 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 391616000494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616000495 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616000496 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616000497 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 391616000498 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391616000499 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391616000500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616000501 Coenzyme A binding pocket [chemical binding]; other site 391616000502 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 391616000503 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391616000504 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391616000505 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391616000506 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 391616000507 Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489 391616000508 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391616000509 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391616000510 Walker A/P-loop; other site 391616000511 ATP binding site [chemical binding]; other site 391616000512 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 391616000513 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 391616000514 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391616000515 Walker B; other site 391616000516 D-loop; other site 391616000517 H-loop/switch region; other site 391616000518 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391616000519 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391616000520 murein hydrolase B; Provisional; Region: PRK10760; cl17906 391616000521 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391616000522 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 391616000523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616000524 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 391616000525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616000526 catalytic residue [active] 391616000527 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391616000528 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391616000529 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391616000530 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 391616000531 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391616000532 putative dimer interface [polypeptide binding]; other site 391616000533 N-terminal domain interface [polypeptide binding]; other site 391616000534 putative substrate binding pocket (H-site) [chemical binding]; other site 391616000535 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 391616000536 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391616000537 putative active site [active] 391616000538 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 391616000539 putative active site [active] 391616000540 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 391616000541 Precorrin-8X methylmutase; Region: CbiC; pfam02570 391616000542 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 391616000543 active site 391616000544 putative homodimer interface [polypeptide binding]; other site 391616000545 SAM binding site [chemical binding]; other site 391616000546 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 391616000547 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 391616000548 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 391616000549 active site 391616000550 SAM binding site [chemical binding]; other site 391616000551 homodimer interface [polypeptide binding]; other site 391616000552 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 391616000553 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 391616000554 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 391616000555 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 391616000556 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 391616000557 active site 391616000558 SAM binding site [chemical binding]; other site 391616000559 homodimer interface [polypeptide binding]; other site 391616000560 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 391616000561 active site 391616000562 SAM binding site [chemical binding]; other site 391616000563 homodimer interface [polypeptide binding]; other site 391616000564 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 391616000565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616000566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616000567 homodimer interface [polypeptide binding]; other site 391616000568 catalytic residue [active] 391616000569 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391616000570 active site 391616000571 catalytic residues [active] 391616000572 metal binding site [ion binding]; metal-binding site 391616000573 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391616000574 active site 391616000575 catalytic residues [active] 391616000576 metal binding site [ion binding]; metal-binding site 391616000577 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391616000578 active site 391616000579 catalytic residues [active] 391616000580 metal binding site [ion binding]; metal-binding site 391616000581 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391616000582 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391616000583 putative active site [active] 391616000584 substrate binding site [chemical binding]; other site 391616000585 putative cosubstrate binding site; other site 391616000586 catalytic site [active] 391616000587 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391616000588 substrate binding site [chemical binding]; other site 391616000589 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 391616000590 RNA/DNA hybrid binding site [nucleotide binding]; other site 391616000591 active site 391616000592 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391616000593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616000594 S-adenosylmethionine binding site [chemical binding]; other site 391616000595 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 391616000596 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 391616000597 Uncharacterized conserved protein [Function unknown]; Region: COG1432 391616000598 LabA_like proteins; Region: LabA; cd10911 391616000599 putative metal binding site [ion binding]; other site 391616000600 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391616000601 catalytic center binding site [active] 391616000602 ATP binding site [chemical binding]; other site 391616000603 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 391616000604 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391616000605 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391616000606 Zn2+ binding site [ion binding]; other site 391616000607 Mg2+ binding site [ion binding]; other site 391616000608 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391616000609 synthetase active site [active] 391616000610 NTP binding site [chemical binding]; other site 391616000611 metal binding site [ion binding]; metal-binding site 391616000612 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391616000613 ACT domain; Region: ACT_4; pfam13291 391616000614 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 391616000615 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 391616000616 active site 391616000617 hydrophilic channel; other site 391616000618 dimerization interface [polypeptide binding]; other site 391616000619 catalytic residues [active] 391616000620 active site lid [active] 391616000621 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391616000622 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 391616000623 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391616000624 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391616000625 Catalytic site [active] 391616000626 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391616000627 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 391616000628 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 391616000629 dimerization interface [polypeptide binding]; other site 391616000630 active site 391616000631 metal binding site [ion binding]; metal-binding site 391616000632 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 391616000633 dsRNA binding site [nucleotide binding]; other site 391616000634 GTPase Era; Reviewed; Region: era; PRK00089 391616000635 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 391616000636 G1 box; other site 391616000637 GTP/Mg2+ binding site [chemical binding]; other site 391616000638 Switch I region; other site 391616000639 G2 box; other site 391616000640 Switch II region; other site 391616000641 G3 box; other site 391616000642 G4 box; other site 391616000643 G5 box; other site 391616000644 KH domain; Region: KH_2; pfam07650 391616000645 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 391616000646 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391616000647 Recombination protein O N terminal; Region: RecO_N; pfam11967 391616000648 Recombination protein O C terminal; Region: RecO_C; pfam02565 391616000649 META domain; Region: META; pfam03724 391616000650 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 391616000651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616000652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391616000653 active site 391616000654 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391616000655 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 391616000656 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 391616000657 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 391616000658 active site 391616000659 substrate-binding site [chemical binding]; other site 391616000660 metal-binding site [ion binding] 391616000661 ATP binding site [chemical binding]; other site 391616000662 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391616000663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616000664 active site 391616000665 phosphorylation site [posttranslational modification] 391616000666 intermolecular recognition site; other site 391616000667 dimerization interface [polypeptide binding]; other site 391616000668 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616000669 DNA binding site [nucleotide binding] 391616000670 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 391616000671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616000672 HAMP domain; Region: HAMP; pfam00672 391616000673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616000674 dimer interface [polypeptide binding]; other site 391616000675 phosphorylation site [posttranslational modification] 391616000676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616000677 ATP binding site [chemical binding]; other site 391616000678 Mg2+ binding site [ion binding]; other site 391616000679 G-X-G motif; other site 391616000680 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 391616000681 Hpr binding site; other site 391616000682 active site 391616000683 homohexamer subunit interaction site [polypeptide binding]; other site 391616000684 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 391616000685 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 391616000686 active pocket/dimerization site; other site 391616000687 active site 391616000688 phosphorylation site [posttranslational modification] 391616000689 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391616000690 dimerization domain swap beta strand [polypeptide binding]; other site 391616000691 regulatory protein interface [polypeptide binding]; other site 391616000692 active site 391616000693 regulatory phosphorylation site [posttranslational modification]; other site 391616000694 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391616000695 putative acyl-acceptor binding pocket; other site 391616000696 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 391616000697 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391616000698 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391616000699 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391616000700 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391616000701 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391616000702 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391616000703 Ligand binding site [chemical binding]; other site 391616000704 Electron transfer flavoprotein domain; Region: ETF; pfam01012 391616000705 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 391616000706 short chain dehydrogenase; Provisional; Region: PRK05993 391616000707 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391616000708 NADP binding site [chemical binding]; other site 391616000709 active site 391616000710 steroid binding site; other site 391616000711 Bacterial SH3 domain homologues; Region: SH3b; smart00287 391616000712 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391616000713 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391616000714 CAP-like domain; other site 391616000715 active site 391616000716 primary dimer interface [polypeptide binding]; other site 391616000717 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616000718 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616000719 elongation factor Tu; Reviewed; Region: PRK00049 391616000720 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391616000721 G1 box; other site 391616000722 GEF interaction site [polypeptide binding]; other site 391616000723 GTP/Mg2+ binding site [chemical binding]; other site 391616000724 Switch I region; other site 391616000725 G2 box; other site 391616000726 G3 box; other site 391616000727 Switch II region; other site 391616000728 G4 box; other site 391616000729 G5 box; other site 391616000730 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391616000731 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391616000732 Antibiotic Binding Site [chemical binding]; other site 391616000733 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391616000734 trimer interface [polypeptide binding]; other site 391616000735 active site 391616000736 substrate binding site [chemical binding]; other site 391616000737 CoA binding site [chemical binding]; other site 391616000738 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 391616000739 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391616000740 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391616000741 putative homodimer interface [polypeptide binding]; other site 391616000742 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 391616000743 heterodimer interface [polypeptide binding]; other site 391616000744 homodimer interface [polypeptide binding]; other site 391616000745 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391616000746 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391616000747 23S rRNA interface [nucleotide binding]; other site 391616000748 L7/L12 interface [polypeptide binding]; other site 391616000749 putative thiostrepton binding site; other site 391616000750 L25 interface [polypeptide binding]; other site 391616000751 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 391616000752 mRNA/rRNA interface [nucleotide binding]; other site 391616000753 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391616000754 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 391616000755 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 391616000756 23S rRNA interface [nucleotide binding]; other site 391616000757 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391616000758 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391616000759 core dimer interface [polypeptide binding]; other site 391616000760 peripheral dimer interface [polypeptide binding]; other site 391616000761 L10 interface [polypeptide binding]; other site 391616000762 L11 interface [polypeptide binding]; other site 391616000763 putative EF-Tu interaction site [polypeptide binding]; other site 391616000764 putative EF-G interaction site [polypeptide binding]; other site 391616000765 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391616000766 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 391616000767 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391616000768 RPB11 interaction site [polypeptide binding]; other site 391616000769 RPB12 interaction site [polypeptide binding]; other site 391616000770 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391616000771 RPB3 interaction site [polypeptide binding]; other site 391616000772 RPB1 interaction site [polypeptide binding]; other site 391616000773 RPB11 interaction site [polypeptide binding]; other site 391616000774 RPB10 interaction site [polypeptide binding]; other site 391616000775 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391616000776 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 391616000777 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 391616000778 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391616000779 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391616000780 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391616000781 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 391616000782 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391616000783 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 391616000784 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391616000785 DNA binding site [nucleotide binding] 391616000786 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391616000787 L-aspartate dehydrogenase; Provisional; Region: PRK13303 391616000788 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391616000789 Domain of unknown function DUF108; Region: DUF108; pfam01958 391616000790 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616000791 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391616000792 S17 interaction site [polypeptide binding]; other site 391616000793 S8 interaction site; other site 391616000794 16S rRNA interaction site [nucleotide binding]; other site 391616000795 streptomycin interaction site [chemical binding]; other site 391616000796 23S rRNA interaction site [nucleotide binding]; other site 391616000797 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391616000798 30S ribosomal protein S7; Validated; Region: PRK05302 391616000799 elongation factor G; Reviewed; Region: PRK00007 391616000800 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 391616000801 G1 box; other site 391616000802 putative GEF interaction site [polypeptide binding]; other site 391616000803 GTP/Mg2+ binding site [chemical binding]; other site 391616000804 Switch I region; other site 391616000805 G2 box; other site 391616000806 G3 box; other site 391616000807 Switch II region; other site 391616000808 G4 box; other site 391616000809 G5 box; other site 391616000810 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391616000811 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391616000812 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391616000813 elongation factor Tu; Reviewed; Region: PRK00049 391616000814 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391616000815 G1 box; other site 391616000816 GEF interaction site [polypeptide binding]; other site 391616000817 GTP/Mg2+ binding site [chemical binding]; other site 391616000818 Switch I region; other site 391616000819 G2 box; other site 391616000820 G3 box; other site 391616000821 Switch II region; other site 391616000822 G4 box; other site 391616000823 G5 box; other site 391616000824 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391616000825 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391616000826 Antibiotic Binding Site [chemical binding]; other site 391616000827 Winged helix-turn helix; Region: HTH_29; pfam13551 391616000828 Winged helix-turn helix; Region: HTH_33; pfam13592 391616000829 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616000830 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616000831 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 391616000832 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 391616000833 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 391616000834 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 391616000835 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 391616000836 Bacterial SH3 domain; Region: SH3_3; pfam08239 391616000837 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616000838 MULE transposase domain; Region: MULE; pfam10551 391616000839 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616000840 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616000841 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616000842 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391616000843 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391616000844 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391616000845 dimer interface [polypeptide binding]; other site 391616000846 motif 1; other site 391616000847 active site 391616000848 motif 2; other site 391616000849 motif 3; other site 391616000850 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 391616000851 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391616000852 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391616000853 putative tRNA-binding site [nucleotide binding]; other site 391616000854 B3/4 domain; Region: B3_4; pfam03483 391616000855 tRNA synthetase B5 domain; Region: B5; smart00874 391616000856 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 391616000857 dimer interface [polypeptide binding]; other site 391616000858 motif 1; other site 391616000859 motif 3; other site 391616000860 motif 2; other site 391616000861 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 391616000862 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616000863 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616000864 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391616000865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616000866 S-adenosylmethionine binding site [chemical binding]; other site 391616000867 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 391616000868 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616000869 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391616000870 C-terminal domain interface [polypeptide binding]; other site 391616000871 GSH binding site (G-site) [chemical binding]; other site 391616000872 dimer interface [polypeptide binding]; other site 391616000873 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 391616000874 dimer interface [polypeptide binding]; other site 391616000875 N-terminal domain interface [polypeptide binding]; other site 391616000876 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 391616000877 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 391616000878 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 391616000879 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 391616000880 hexamer interface [polypeptide binding]; other site 391616000881 ligand binding site [chemical binding]; other site 391616000882 putative active site [active] 391616000883 NAD(P) binding site [chemical binding]; other site 391616000884 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616000885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616000886 dimerization interface [polypeptide binding]; other site 391616000887 putative DNA binding site [nucleotide binding]; other site 391616000888 putative Zn2+ binding site [ion binding]; other site 391616000889 AsnC family; Region: AsnC_trans_reg; pfam01037 391616000890 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 391616000891 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391616000892 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 391616000893 COQ9; Region: COQ9; pfam08511 391616000894 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391616000895 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391616000896 NAD(P) binding site [chemical binding]; other site 391616000897 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616000898 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616000899 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616000900 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616000901 Integrase core domain; Region: rve; pfam00665 391616000902 Integrase core domain; Region: rve_3; pfam13683 391616000903 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 391616000904 dimerization interface [polypeptide binding]; other site 391616000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616000906 dimer interface [polypeptide binding]; other site 391616000907 phosphorylation site [posttranslational modification] 391616000908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616000909 ATP binding site [chemical binding]; other site 391616000910 Mg2+ binding site [ion binding]; other site 391616000911 G-X-G motif; other site 391616000912 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616000913 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616000914 Integrase core domain; Region: rve; pfam00665 391616000915 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 391616000916 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 391616000917 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 391616000918 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 391616000919 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 391616000920 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391616000921 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391616000922 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 391616000923 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391616000924 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 391616000925 nucleotide binding site [chemical binding]; other site 391616000926 putative NEF/HSP70 interaction site [polypeptide binding]; other site 391616000927 SBD interface [polypeptide binding]; other site 391616000928 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 391616000929 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616000930 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391616000931 lipoyl attachment site [posttranslational modification]; other site 391616000932 glycine dehydrogenase; Provisional; Region: PRK05367 391616000933 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391616000934 tetramer interface [polypeptide binding]; other site 391616000935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616000936 catalytic residue [active] 391616000937 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391616000938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616000939 tetramer interface [polypeptide binding]; other site 391616000940 catalytic residue [active] 391616000941 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 391616000942 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 391616000943 DNA binding residues [nucleotide binding] 391616000944 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616000945 MULE transposase domain; Region: MULE; pfam10551 391616000946 Transposase; Region: HTH_Tnp_1; cl17663 391616000947 Integrase core domain; Region: rve; pfam00665 391616000948 Integrase core domain; Region: rve_3; pfam13683 391616000949 UreD urease accessory protein; Region: UreD; pfam01774 391616000950 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 391616000951 alpha-gamma subunit interface [polypeptide binding]; other site 391616000952 beta-gamma subunit interface [polypeptide binding]; other site 391616000953 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 391616000954 gamma-beta subunit interface [polypeptide binding]; other site 391616000955 alpha-beta subunit interface [polypeptide binding]; other site 391616000956 urease subunit alpha; Reviewed; Region: ureC; PRK13207 391616000957 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 391616000958 subunit interactions [polypeptide binding]; other site 391616000959 active site 391616000960 flap region; other site 391616000961 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 391616000962 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 391616000963 dimer interface [polypeptide binding]; other site 391616000964 catalytic residues [active] 391616000965 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 391616000966 UreF; Region: UreF; pfam01730 391616000967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391616000968 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391616000969 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 391616000970 DNA binding residues [nucleotide binding] 391616000971 dimer interface [polypeptide binding]; other site 391616000972 copper binding site [ion binding]; other site 391616000973 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391616000974 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391616000975 metal-binding site [ion binding] 391616000976 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391616000977 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391616000978 Cytochrome c; Region: Cytochrom_C; pfam00034 391616000979 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391616000980 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391616000981 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391616000982 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391616000983 aminodeoxychorismate synthase; Provisional; Region: PRK07508 391616000984 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391616000985 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391616000986 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391616000987 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616000988 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391616000989 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391616000990 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616000991 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616000992 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616000993 active site 391616000994 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391616000995 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 391616000996 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616000997 catalytic residue [active] 391616000998 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616000999 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616001000 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616001001 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391616001002 iron-sulfur cluster [ion binding]; other site 391616001003 [2Fe-2S] cluster binding site [ion binding]; other site 391616001004 C-terminal catalytic domain of the oxygenase alpha subunit of dicamba O-demethylase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_DMO-like; cd08878 391616001005 alpha subunit interface [polypeptide binding]; other site 391616001006 active site 391616001007 substrate binding site [chemical binding]; other site 391616001008 Fe binding site [ion binding]; other site 391616001009 urocanate hydratase; Provisional; Region: PRK05414 391616001010 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391616001011 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391616001012 active sites [active] 391616001013 tetramer interface [polypeptide binding]; other site 391616001014 imidazolonepropionase; Validated; Region: PRK09356 391616001015 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 391616001016 active site 391616001017 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391616001018 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 391616001019 active site 391616001020 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616001021 DNA-binding site [nucleotide binding]; DNA binding site 391616001022 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 391616001023 UTRA domain; Region: UTRA; pfam07702 391616001024 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 391616001025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616001026 substrate binding pocket [chemical binding]; other site 391616001027 membrane-bound complex binding site; other site 391616001028 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616001029 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391616001030 Walker A/P-loop; other site 391616001031 ATP binding site [chemical binding]; other site 391616001032 Q-loop/lid; other site 391616001033 ABC transporter signature motif; other site 391616001034 Walker B; other site 391616001035 D-loop; other site 391616001036 H-loop/switch region; other site 391616001037 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616001038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001039 dimer interface [polypeptide binding]; other site 391616001040 conserved gate region; other site 391616001041 ABC-ATPase subunit interface; other site 391616001042 NMT1/THI5 like; Region: NMT1; pfam09084 391616001043 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616001044 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 391616001045 dimer interface [polypeptide binding]; other site 391616001046 conserved gate region; other site 391616001047 putative PBP binding loops; other site 391616001048 ABC-ATPase subunit interface; other site 391616001049 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616001050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001051 dimer interface [polypeptide binding]; other site 391616001052 conserved gate region; other site 391616001053 ABC-ATPase subunit interface; other site 391616001054 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616001055 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391616001056 Walker A/P-loop; other site 391616001057 ATP binding site [chemical binding]; other site 391616001058 Q-loop/lid; other site 391616001059 ABC transporter signature motif; other site 391616001060 Walker B; other site 391616001061 D-loop; other site 391616001062 H-loop/switch region; other site 391616001063 phenylhydantoinase; Validated; Region: PRK08323 391616001064 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 391616001065 tetramer interface [polypeptide binding]; other site 391616001066 active site 391616001067 allantoate amidohydrolase; Reviewed; Region: PRK12893 391616001068 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391616001069 active site 391616001070 metal binding site [ion binding]; metal-binding site 391616001071 dimer interface [polypeptide binding]; other site 391616001072 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616001073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616001074 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 391616001075 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001076 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001077 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001079 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 391616001080 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 391616001081 homodimer interface [polypeptide binding]; other site 391616001082 active site 391616001083 FMN binding site [chemical binding]; other site 391616001084 substrate binding site [chemical binding]; other site 391616001085 4Fe-4S binding domain; Region: Fer4; cl02805 391616001086 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391616001087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616001088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616001089 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 391616001090 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 391616001091 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 391616001092 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 391616001093 intersubunit interface [polypeptide binding]; other site 391616001094 active site 391616001095 Zn2+ binding site [ion binding]; other site 391616001096 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 391616001097 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391616001098 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 391616001099 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 391616001100 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 391616001101 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 391616001102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391616001103 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 391616001104 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 391616001105 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 391616001106 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616001107 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 391616001108 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616001109 DctM-like transporters; Region: DctM; pfam06808 391616001110 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616001111 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616001112 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616001113 choline dehydrogenase; Validated; Region: PRK02106 391616001114 lycopene cyclase; Region: lycopene_cycl; TIGR01789 391616001115 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616001116 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 391616001117 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391616001118 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 391616001119 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391616001120 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391616001121 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391616001122 putative S-transferase; Provisional; Region: PRK11752 391616001123 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391616001124 C-terminal domain interface [polypeptide binding]; other site 391616001125 GSH binding site (G-site) [chemical binding]; other site 391616001126 dimer interface [polypeptide binding]; other site 391616001127 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 391616001128 dimer interface [polypeptide binding]; other site 391616001129 N-terminal domain interface [polypeptide binding]; other site 391616001130 active site 391616001131 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391616001132 Methyltransferase domain; Region: Methyltransf_12; pfam08242 391616001133 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616001134 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616001135 Integrase core domain; Region: rve; pfam00665 391616001136 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616001137 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001138 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001139 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001140 Homeodomain-like domain; Region: HTH_32; pfam13565 391616001141 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001142 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616001143 DNA binding site [nucleotide binding] 391616001144 active site 391616001145 Int/Topo IB signature motif; other site 391616001146 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001147 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001148 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001149 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 391616001151 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 391616001152 Protein of unknown function DUF45; Region: DUF45; pfam01863 391616001153 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391616001154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616001155 DNA-binding site [nucleotide binding]; DNA binding site 391616001156 FCD domain; Region: FCD; pfam07729 391616001157 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616001158 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616001159 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001160 Integrase core domain; Region: rve; pfam00665 391616001161 Integrase core domain; Region: rve_3; pfam13683 391616001162 tellurium resistance terB-like protein; Region: terB_like; cd07177 391616001163 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 391616001164 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 391616001165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616001166 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616001167 MAPEG family; Region: MAPEG; pfam01124 391616001168 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616001169 E3 interaction surface; other site 391616001170 lipoyl attachment site [posttranslational modification]; other site 391616001171 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616001172 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 391616001173 E3 interaction surface; other site 391616001174 lipoyl attachment site [posttranslational modification]; other site 391616001175 e3 binding domain; Region: E3_binding; pfam02817 391616001176 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391616001177 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 391616001178 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 391616001179 TPP-binding site [chemical binding]; other site 391616001180 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 391616001181 dimer interface [polypeptide binding]; other site 391616001182 PYR/PP interface [polypeptide binding]; other site 391616001183 TPP binding site [chemical binding]; other site 391616001184 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391616001185 CoA binding domain; Region: CoA_binding; pfam02629 391616001186 CoA-ligase; Region: Ligase_CoA; pfam00549 391616001187 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391616001188 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391616001189 CoA-ligase; Region: Ligase_CoA; pfam00549 391616001190 malate dehydrogenase; Reviewed; Region: PRK06223 391616001191 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 391616001192 NAD(P) binding site [chemical binding]; other site 391616001193 dimer interface [polypeptide binding]; other site 391616001194 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391616001195 substrate binding site [chemical binding]; other site 391616001196 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391616001197 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616001198 Integrase core domain; Region: rve; pfam00665 391616001199 Integrase core domain; Region: rve_3; pfam13683 391616001200 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616001201 Transposase; Region: HTH_Tnp_1; cl17663 391616001202 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391616001203 NnrU protein; Region: NnrU; pfam07298 391616001204 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 391616001205 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391616001206 putative active site [active] 391616001207 putative catalytic site [active] 391616001208 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391616001209 putative active site [active] 391616001210 putative catalytic site [active] 391616001211 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391616001212 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 391616001213 Iron-sulfur protein interface; other site 391616001214 proximal quinone binding site [chemical binding]; other site 391616001215 SdhD (CybS) interface [polypeptide binding]; other site 391616001216 proximal heme binding site [chemical binding]; other site 391616001217 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 391616001218 putative SdhC subunit interface [polypeptide binding]; other site 391616001219 putative proximal heme binding site [chemical binding]; other site 391616001220 putative Iron-sulfur protein interface [polypeptide binding]; other site 391616001221 putative proximal quinone binding site; other site 391616001222 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 391616001223 L-aspartate oxidase; Provisional; Region: PRK06175 391616001224 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391616001225 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391616001226 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391616001227 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391616001228 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 391616001229 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 391616001230 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616001231 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616001232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616001233 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616001234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391616001235 H-NS histone family; Region: Histone_HNS; pfam00816 391616001236 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616001237 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001238 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001239 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001241 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391616001242 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391616001243 B12 binding site [chemical binding]; other site 391616001244 cobalt ligand [ion binding]; other site 391616001245 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391616001246 putative acyl-acceptor binding pocket; other site 391616001247 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 391616001248 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 391616001249 putative NAD(P) binding site [chemical binding]; other site 391616001250 AAA domain; Region: AAA_30; pfam13604 391616001251 Family description; Region: UvrD_C_2; pfam13538 391616001252 classical (c) SDRs; Region: SDR_c; cd05233 391616001253 NAD(P) binding site [chemical binding]; other site 391616001254 active site 391616001255 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 391616001256 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391616001257 hypothetical protein; Provisional; Region: PRK10621 391616001258 purine nucleoside phosphorylase; Provisional; Region: PRK08202 391616001259 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616001260 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616001261 TM-ABC transporter signature motif; other site 391616001262 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391616001263 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616001264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616001265 TM-ABC transporter signature motif; other site 391616001266 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391616001267 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616001268 Walker A/P-loop; other site 391616001269 ATP binding site [chemical binding]; other site 391616001270 Q-loop/lid; other site 391616001271 ABC transporter signature motif; other site 391616001272 Walker B; other site 391616001273 D-loop; other site 391616001274 H-loop/switch region; other site 391616001275 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616001276 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 391616001277 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391616001278 ligand binding site [chemical binding]; other site 391616001279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616001280 Coenzyme A binding pocket [chemical binding]; other site 391616001281 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391616001282 Glycoprotease family; Region: Peptidase_M22; pfam00814 391616001283 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 391616001284 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391616001285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391616001286 Ligand Binding Site [chemical binding]; other site 391616001287 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 391616001288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616001289 putative metal binding site [ion binding]; other site 391616001290 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391616001291 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391616001292 active site 391616001293 HIGH motif; other site 391616001294 dimer interface [polypeptide binding]; other site 391616001295 KMSKS motif; other site 391616001296 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391616001297 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 391616001298 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 391616001299 Protein of unknown function, DUF481; Region: DUF481; pfam04338 391616001300 transcriptional regulator HdfR; Provisional; Region: PRK03601 391616001301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616001302 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391616001303 dimerization interface [polypeptide binding]; other site 391616001304 PII uridylyl-transferase; Provisional; Region: PRK05092 391616001305 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391616001306 metal binding triad; other site 391616001307 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391616001308 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391616001309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391616001310 Zn2+ binding site [ion binding]; other site 391616001311 Mg2+ binding site [ion binding]; other site 391616001312 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 391616001313 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 391616001314 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 391616001315 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391616001316 putative ligand binding site [chemical binding]; other site 391616001317 Predicted methyltransferases [General function prediction only]; Region: COG0313 391616001318 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 391616001319 putative SAM binding site [chemical binding]; other site 391616001320 putative homodimer interface [polypeptide binding]; other site 391616001321 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 391616001322 glutathione synthetase; Provisional; Region: PRK05246 391616001323 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 391616001324 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 391616001325 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001326 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001327 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001329 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 391616001330 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 391616001331 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391616001332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616001333 Walker A motif; other site 391616001334 ATP binding site [chemical binding]; other site 391616001335 Walker B motif; other site 391616001336 arginine finger; other site 391616001337 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 391616001338 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 391616001339 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 391616001340 homotrimer interface [polypeptide binding]; other site 391616001341 Walker A motif; other site 391616001342 GTP binding site [chemical binding]; other site 391616001343 Walker B motif; other site 391616001344 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 391616001345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616001346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 391616001347 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391616001348 Flavoprotein; Region: Flavoprotein; pfam02441 391616001349 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 391616001350 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391616001351 trimer interface [polypeptide binding]; other site 391616001352 active site 391616001353 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 391616001354 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391616001355 ATP binding site [chemical binding]; other site 391616001356 substrate interface [chemical binding]; other site 391616001357 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616001358 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001360 dimer interface [polypeptide binding]; other site 391616001361 conserved gate region; other site 391616001362 putative PBP binding loops; other site 391616001363 ABC-ATPase subunit interface; other site 391616001364 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 391616001365 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 391616001366 active site 391616001367 Zn binding site [ion binding]; other site 391616001368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 391616001369 Bacterial SH3 domain; Region: SH3_4; pfam06347 391616001370 Bacterial SH3 domain; Region: SH3_4; pfam06347 391616001371 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391616001372 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391616001373 dimerization interface [polypeptide binding]; other site 391616001374 ligand binding site [chemical binding]; other site 391616001375 NADP binding site [chemical binding]; other site 391616001376 catalytic site [active] 391616001377 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 391616001378 nucleophilic elbow; other site 391616001379 catalytic triad; other site 391616001380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616001381 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616001382 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616001383 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616001384 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616001385 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616001386 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616001387 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616001388 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616001389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616001390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616001391 active site 391616001392 catalytic tetrad [active] 391616001393 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391616001394 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391616001395 putative ligand binding site [chemical binding]; other site 391616001396 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616001397 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616001398 TM-ABC transporter signature motif; other site 391616001399 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616001400 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616001401 TM-ABC transporter signature motif; other site 391616001402 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391616001403 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616001404 Walker A/P-loop; other site 391616001405 ATP binding site [chemical binding]; other site 391616001406 Q-loop/lid; other site 391616001407 ABC transporter signature motif; other site 391616001408 Walker B; other site 391616001409 D-loop; other site 391616001410 H-loop/switch region; other site 391616001411 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616001412 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391616001413 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391616001414 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391616001415 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 391616001416 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391616001417 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616001418 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 391616001419 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616001420 catalytic loop [active] 391616001421 iron binding site [ion binding]; other site 391616001422 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391616001423 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391616001424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616001425 dimerization interface [polypeptide binding]; other site 391616001426 putative DNA binding site [nucleotide binding]; other site 391616001427 putative Zn2+ binding site [ion binding]; other site 391616001428 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391616001429 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 391616001430 putative active site [active] 391616001431 putative PHP Thumb interface [polypeptide binding]; other site 391616001432 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391616001433 generic binding surface II; other site 391616001434 generic binding surface I; other site 391616001435 SlyX; Region: SlyX; pfam04102 391616001436 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 391616001437 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 391616001438 dimer interface [polypeptide binding]; other site 391616001439 motif 1; other site 391616001440 active site 391616001441 motif 2; other site 391616001442 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391616001443 active site 391616001444 motif 3; other site 391616001445 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391616001446 anticodon binding site; other site 391616001447 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 391616001448 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391616001449 active site 391616001450 dimer interface [polypeptide binding]; other site 391616001451 motif 2; other site 391616001452 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391616001453 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 391616001454 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 391616001455 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 391616001456 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391616001457 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391616001458 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391616001459 active site 391616001460 dimer interface [polypeptide binding]; other site 391616001461 effector binding site; other site 391616001462 TSCPD domain; Region: TSCPD; pfam12637 391616001463 Hint domain; Region: Hint_2; pfam13403 391616001464 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391616001465 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391616001466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616001467 RNA binding surface [nucleotide binding]; other site 391616001468 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 391616001469 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616001470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616001471 homodimer interface [polypeptide binding]; other site 391616001472 catalytic residue [active] 391616001473 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 391616001474 prephenate dehydrogenase; Validated; Region: PRK08507 391616001475 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391616001476 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391616001477 putative active site pocket [active] 391616001478 dimerization interface [polypeptide binding]; other site 391616001479 putative catalytic residue [active] 391616001480 hypothetical protein; Validated; Region: PRK09039 391616001481 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616001482 ligand binding site [chemical binding]; other site 391616001483 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616001484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616001485 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616001486 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616001487 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 391616001488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616001489 Walker A motif; other site 391616001490 ATP binding site [chemical binding]; other site 391616001491 Walker B motif; other site 391616001492 arginine finger; other site 391616001493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616001494 Walker A motif; other site 391616001495 ATP binding site [chemical binding]; other site 391616001496 Walker B motif; other site 391616001497 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391616001498 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 391616001499 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391616001500 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391616001501 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 391616001502 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 391616001503 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391616001504 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391616001505 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391616001506 beta subunit interaction interface [polypeptide binding]; other site 391616001507 Walker A motif; other site 391616001508 ATP binding site [chemical binding]; other site 391616001509 Walker B motif; other site 391616001510 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391616001511 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 391616001512 core domain interface [polypeptide binding]; other site 391616001513 delta subunit interface [polypeptide binding]; other site 391616001514 epsilon subunit interface [polypeptide binding]; other site 391616001515 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391616001516 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391616001517 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391616001518 alpha subunit interaction interface [polypeptide binding]; other site 391616001519 Walker A motif; other site 391616001520 ATP binding site [chemical binding]; other site 391616001521 Walker B motif; other site 391616001522 inhibitor binding site; inhibition site 391616001523 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391616001524 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 391616001525 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391616001526 gamma subunit interface [polypeptide binding]; other site 391616001527 epsilon subunit interface [polypeptide binding]; other site 391616001528 LBP interface [polypeptide binding]; other site 391616001529 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391616001530 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001531 Homeodomain-like domain; Region: HTH_32; pfam13565 391616001532 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001533 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001535 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616001536 Integrase core domain; Region: rve; pfam00665 391616001537 Integrase core domain; Region: rve_3; pfam13683 391616001538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616001539 Transposase; Region: HTH_Tnp_1; cl17663 391616001540 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391616001541 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616001542 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616001543 active site 391616001544 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 391616001545 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391616001546 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391616001547 ABC-ATPase subunit interface; other site 391616001548 dimer interface [polypeptide binding]; other site 391616001549 putative PBP binding regions; other site 391616001550 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391616001551 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391616001552 ABC-ATPase subunit interface; other site 391616001553 dimer interface [polypeptide binding]; other site 391616001554 putative PBP binding regions; other site 391616001555 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 391616001556 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391616001557 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 391616001558 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 391616001559 metal binding site [ion binding]; metal-binding site 391616001560 Predicted membrane protein [Function unknown]; Region: COG3748 391616001561 Protein of unknown function (DUF989); Region: DUF989; pfam06181 391616001562 Cytochrome c; Region: Cytochrom_C; pfam00034 391616001563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616001564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616001565 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616001566 putative effector binding pocket; other site 391616001567 dimerization interface [polypeptide binding]; other site 391616001568 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 391616001569 active site 391616001570 homotetramer interface [polypeptide binding]; other site 391616001571 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391616001572 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391616001573 active site 391616001574 catalytic site [active] 391616001575 tetramer interface [polypeptide binding]; other site 391616001576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 391616001577 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 391616001578 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 391616001579 xanthine permease; Region: pbuX; TIGR03173 391616001580 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 391616001581 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391616001582 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819 391616001583 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 391616001584 dimer interface [polypeptide binding]; other site 391616001585 active site 391616001586 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391616001587 substrate binding site [chemical binding]; other site 391616001588 catalytic residue [active] 391616001589 serine racemase; Region: PLN02970 391616001590 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391616001591 tetramer interface [polypeptide binding]; other site 391616001592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616001593 catalytic residue [active] 391616001594 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 391616001595 homodimer interface [polypeptide binding]; other site 391616001596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616001597 catalytic residue [active] 391616001598 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391616001599 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616001600 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616001601 hypothetical protein; Provisional; Region: PRK11171 391616001602 Cupin domain; Region: Cupin_2; pfam07883 391616001603 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 391616001604 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616001605 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616001606 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616001607 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001608 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001609 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001610 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001611 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 391616001612 DHH family; Region: DHH; pfam01368 391616001613 DHHA1 domain; Region: DHHA1; pfam02272 391616001614 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 391616001615 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 391616001616 putative active site [active] 391616001617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 391616001618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616001619 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616001620 homoserine dehydrogenase; Provisional; Region: PRK06349 391616001621 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391616001622 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391616001623 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391616001624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616001625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616001626 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616001627 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 391616001628 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391616001629 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391616001630 TadE-like protein; Region: TadE; pfam07811 391616001631 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001632 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001633 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001634 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001635 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001636 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001637 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001639 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616001640 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616001641 Integrase core domain; Region: rve; pfam00665 391616001642 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391616001643 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391616001644 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391616001645 NAD(P) binding site [chemical binding]; other site 391616001646 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391616001647 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616001648 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391616001649 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391616001650 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616001651 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616001652 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391616001653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616001654 Walker A/P-loop; other site 391616001655 ATP binding site [chemical binding]; other site 391616001656 Q-loop/lid; other site 391616001657 ABC transporter signature motif; other site 391616001658 Walker B; other site 391616001659 D-loop; other site 391616001660 H-loop/switch region; other site 391616001661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001662 dimer interface [polypeptide binding]; other site 391616001663 conserved gate region; other site 391616001664 putative PBP binding loops; other site 391616001665 ABC-ATPase subunit interface; other site 391616001666 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 391616001667 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391616001668 transcriptional regulator BetI; Validated; Region: PRK00767 391616001669 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616001670 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391616001671 Sulfatase; Region: Sulfatase; cl17466 391616001672 choline-sulfatase; Region: chol_sulfatase; TIGR03417 391616001673 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 391616001674 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 391616001675 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616001676 NAD(P) binding site [chemical binding]; other site 391616001677 catalytic residues [active] 391616001678 choline dehydrogenase; Validated; Region: PRK02106 391616001679 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616001680 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616001681 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 391616001682 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 391616001683 Catalytic site; other site 391616001684 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391616001685 putative hydrophobic ligand binding site [chemical binding]; other site 391616001686 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616001687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616001688 non-specific DNA binding site [nucleotide binding]; other site 391616001689 salt bridge; other site 391616001690 sequence-specific DNA binding site [nucleotide binding]; other site 391616001691 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391616001692 Domain of unknown function (DUF955); Region: DUF955; pfam06114 391616001693 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391616001694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616001695 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 391616001696 putative substrate translocation pore; other site 391616001697 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391616001698 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391616001699 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391616001700 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391616001701 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616001702 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391616001703 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391616001704 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391616001705 carboxyltransferase (CT) interaction site; other site 391616001706 biotinylation site [posttranslational modification]; other site 391616001707 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 391616001708 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 391616001709 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 391616001710 active site 391616001711 substrate binding site [chemical binding]; other site 391616001712 coenzyme B12 binding site [chemical binding]; other site 391616001713 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391616001714 B12 binding site [chemical binding]; other site 391616001715 cobalt ligand [ion binding]; other site 391616001716 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391616001717 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 391616001718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616001719 Coenzyme A binding pocket [chemical binding]; other site 391616001720 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 391616001721 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 391616001722 putative metal binding site [ion binding]; other site 391616001723 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391616001724 HSP70 interaction site [polypeptide binding]; other site 391616001725 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391616001726 putative catalytic site [active] 391616001727 putative phosphate binding site [ion binding]; other site 391616001728 putative metal binding site [ion binding]; other site 391616001729 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391616001730 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391616001731 polyphosphate kinase; Provisional; Region: PRK05443 391616001732 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 391616001733 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 391616001734 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 391616001735 putative domain interface [polypeptide binding]; other site 391616001736 putative active site [active] 391616001737 catalytic site [active] 391616001738 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 391616001739 putative domain interface [polypeptide binding]; other site 391616001740 putative active site [active] 391616001741 catalytic site [active] 391616001742 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 391616001743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391616001744 Walker A motif; other site 391616001745 ATP binding site [chemical binding]; other site 391616001746 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391616001747 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391616001748 Fasciclin domain; Region: Fasciclin; pfam02469 391616001749 prolyl-tRNA synthetase; Provisional; Region: PRK12325 391616001750 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 391616001751 dimer interface [polypeptide binding]; other site 391616001752 motif 1; other site 391616001753 active site 391616001754 motif 2; other site 391616001755 motif 3; other site 391616001756 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 391616001757 anticodon binding site; other site 391616001758 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 391616001759 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391616001760 FtsX-like permease family; Region: FtsX; pfam02687 391616001761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391616001762 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391616001763 Walker A/P-loop; other site 391616001764 ATP binding site [chemical binding]; other site 391616001765 Q-loop/lid; other site 391616001766 ABC transporter signature motif; other site 391616001767 Walker B; other site 391616001768 D-loop; other site 391616001769 H-loop/switch region; other site 391616001770 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391616001771 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 391616001772 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616001773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616001774 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616001775 Cytochrome c; Region: Cytochrom_C; pfam00034 391616001776 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391616001777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616001778 Mg2+ binding site [ion binding]; other site 391616001779 G-X-G motif; other site 391616001780 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391616001781 anchoring element; other site 391616001782 dimer interface [polypeptide binding]; other site 391616001783 ATP binding site [chemical binding]; other site 391616001784 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391616001785 active site 391616001786 metal binding site [ion binding]; metal-binding site 391616001787 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391616001788 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 391616001789 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391616001790 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 391616001791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391616001792 motif II; other site 391616001793 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391616001794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616001795 DNA-binding site [nucleotide binding]; DNA binding site 391616001796 FCD domain; Region: FCD; pfam07729 391616001797 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001798 Integrase core domain; Region: rve; pfam00665 391616001799 Integrase core domain; Region: rve_3; pfam13683 391616001800 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391616001801 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 391616001802 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391616001803 catalytic site [active] 391616001804 subunit interface [polypeptide binding]; other site 391616001805 Yqey-like protein; Region: YqeY; pfam09424 391616001806 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616001807 EamA-like transporter family; Region: EamA; pfam00892 391616001808 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 391616001809 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616001810 Integrase core domain; Region: rve; pfam00665 391616001811 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 391616001812 Subunit I/III interface [polypeptide binding]; other site 391616001813 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391616001814 D-pathway; other site 391616001815 Subunit I/VIIc interface [polypeptide binding]; other site 391616001816 Subunit I/IV interface [polypeptide binding]; other site 391616001817 Subunit I/II interface [polypeptide binding]; other site 391616001818 Low-spin heme (heme a) binding site [chemical binding]; other site 391616001819 Subunit I/VIIa interface [polypeptide binding]; other site 391616001820 Dimer interface; other site 391616001821 Subunit I/VIa interface [polypeptide binding]; other site 391616001822 Putative water exit pathway; other site 391616001823 Binuclear center (heme a3/CuB) [ion binding]; other site 391616001824 K-pathway; other site 391616001825 Subunit I/Vb interface [polypeptide binding]; other site 391616001826 Putative proton exit pathway; other site 391616001827 Subunit I/VIb interface; other site 391616001828 Subunit I/VIc interface [polypeptide binding]; other site 391616001829 Electron transfer pathway; other site 391616001830 Subunit I/VIIIb interface [polypeptide binding]; other site 391616001831 Subunit I/VIIb interface [polypeptide binding]; other site 391616001832 Transcriptional regulator; Region: Rrf2; cl17282 391616001833 Predicted transcriptional regulator [Transcription]; Region: COG1959 391616001834 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 391616001835 heme-binding site [chemical binding]; other site 391616001836 lipoate-protein ligase B; Provisional; Region: PRK14341 391616001837 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616001838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616001839 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616001840 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 391616001841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616001842 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616001843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616001844 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616001845 Transposase; Region: HTH_Tnp_1; cl17663 391616001846 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 391616001847 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391616001848 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391616001849 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 391616001850 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391616001851 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616001852 AsnC family; Region: AsnC_trans_reg; pfam01037 391616001853 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616001854 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391616001855 putative DNA binding site [nucleotide binding]; other site 391616001856 putative Zn2+ binding site [ion binding]; other site 391616001857 AsnC family; Region: AsnC_trans_reg; pfam01037 391616001858 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616001859 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616001860 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391616001861 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616001862 catalytic residue [active] 391616001863 multidrug efflux protein; Reviewed; Region: PRK01766 391616001864 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 391616001865 cation binding site [ion binding]; other site 391616001866 aspartate aminotransferase; Provisional; Region: PRK05764 391616001867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616001868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616001869 homodimer interface [polypeptide binding]; other site 391616001870 catalytic residue [active] 391616001871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616001872 non-specific DNA binding site [nucleotide binding]; other site 391616001873 salt bridge; other site 391616001874 sequence-specific DNA binding site [nucleotide binding]; other site 391616001875 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001876 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001877 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001879 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001880 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001881 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001882 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616001884 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616001885 MULE transposase domain; Region: MULE; pfam10551 391616001886 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616001887 MULE transposase domain; Region: MULE; pfam10551 391616001888 Integrase core domain; Region: rve; pfam00665 391616001889 Integrase core domain; Region: rve_3; pfam13683 391616001890 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391616001891 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616001892 catalytic residues [active] 391616001893 catalytic nucleophile [active] 391616001894 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616001895 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616001896 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616001897 Synaptic Site I dimer interface [polypeptide binding]; other site 391616001898 DNA binding site [nucleotide binding] 391616001899 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391616001900 DNA-binding interface [nucleotide binding]; DNA binding site 391616001901 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616001902 MULE transposase domain; Region: MULE; pfam10551 391616001903 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001904 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001905 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616001907 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391616001908 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391616001909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616001910 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391616001911 dimer interface [polypeptide binding]; other site 391616001912 active site 391616001913 metal binding site [ion binding]; metal-binding site 391616001914 glutathione binding site [chemical binding]; other site 391616001915 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616001916 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 391616001917 Homeodomain-like domain; Region: HTH_23; pfam13384 391616001918 Winged helix-turn helix; Region: HTH_29; pfam13551 391616001919 Winged helix-turn helix; Region: HTH_33; pfam13592 391616001920 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616001921 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616001922 MULE transposase domain; Region: MULE; pfam10551 391616001923 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616001924 Transposase; Region: HTH_Tnp_1; cl17663 391616001925 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616001926 Predicted membrane protein [Function unknown]; Region: COG2259 391616001927 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 391616001928 hypothetical protein; Provisional; Region: PRK05409 391616001929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 391616001930 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 391616001931 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 391616001932 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 391616001933 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391616001934 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391616001935 active site 391616001936 dimer interface [polypeptide binding]; other site 391616001937 motif 1; other site 391616001938 motif 2; other site 391616001939 motif 3; other site 391616001940 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 391616001941 anticodon binding site; other site 391616001942 MAPEG family; Region: MAPEG; pfam01124 391616001943 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616001944 dimerization interface [polypeptide binding]; other site 391616001945 putative DNA binding site [nucleotide binding]; other site 391616001946 putative Zn2+ binding site [ion binding]; other site 391616001947 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391616001948 hydrophobic ligand binding site; other site 391616001949 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616001950 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391616001951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616001952 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616001953 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391616001954 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 391616001955 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 391616001956 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 391616001957 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 391616001958 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 391616001959 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 391616001960 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391616001961 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616001962 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616001963 catalytic residue [active] 391616001964 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391616001965 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391616001966 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 391616001967 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391616001968 catalytic triad [active] 391616001969 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391616001970 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391616001971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001972 dimer interface [polypeptide binding]; other site 391616001973 conserved gate region; other site 391616001974 putative PBP binding loops; other site 391616001975 ABC-ATPase subunit interface; other site 391616001976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616001977 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616001979 ABC-ATPase subunit interface; other site 391616001980 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616001981 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616001982 substrate binding pocket [chemical binding]; other site 391616001983 membrane-bound complex binding site; other site 391616001984 hinge residues; other site 391616001985 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616001986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616001987 substrate binding pocket [chemical binding]; other site 391616001988 membrane-bound complex binding site; other site 391616001989 hinge residues; other site 391616001990 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616001991 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616001992 Walker A/P-loop; other site 391616001993 ATP binding site [chemical binding]; other site 391616001994 Q-loop/lid; other site 391616001995 ABC transporter signature motif; other site 391616001996 Walker B; other site 391616001997 D-loop; other site 391616001998 H-loop/switch region; other site 391616001999 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 391616002000 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391616002001 putative metal binding site [ion binding]; other site 391616002002 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002003 Integrase core domain; Region: rve; pfam00665 391616002004 Integrase core domain; Region: rve_3; pfam13683 391616002005 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391616002006 putative metal binding site [ion binding]; other site 391616002007 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 391616002008 Sorting nexin C terminal; Region: Nexin_C; pfam08628 391616002009 CTP synthetase; Validated; Region: pyrG; PRK05380 391616002010 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 391616002011 Catalytic site [active] 391616002012 active site 391616002013 UTP binding site [chemical binding]; other site 391616002014 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391616002015 active site 391616002016 putative oxyanion hole; other site 391616002017 catalytic triad [active] 391616002018 protein translocase, SecG subunit; Region: secG; TIGR00810 391616002019 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391616002020 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391616002021 GDP-binding site [chemical binding]; other site 391616002022 ACT binding site; other site 391616002023 IMP binding site; other site 391616002024 Thiamine pyrophosphokinase; Region: TPK; cd07995 391616002025 active site 391616002026 dimerization interface [polypeptide binding]; other site 391616002027 thiamine binding site [chemical binding]; other site 391616002028 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616002029 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616002030 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 391616002031 substrate binding pocket [chemical binding]; other site 391616002032 active site 391616002033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616002034 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616002035 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002036 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002037 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002039 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391616002040 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391616002041 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 391616002042 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 391616002043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391616002044 active site 391616002045 dimer interface [polypeptide binding]; other site 391616002046 glutathione reductase; Validated; Region: PRK06116 391616002047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616002048 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616002049 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616002050 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 391616002051 HflK protein; Region: hflK; TIGR01933 391616002052 HflC protein; Region: hflC; TIGR01932 391616002053 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 391616002054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391616002055 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391616002056 ligand binding site [chemical binding]; other site 391616002057 flexible hinge region; other site 391616002058 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391616002059 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391616002060 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391616002061 protein binding site [polypeptide binding]; other site 391616002062 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391616002063 protein binding site [polypeptide binding]; other site 391616002064 ACT domain; Region: ACT_3; pfam10000 391616002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 391616002066 Family description; Region: ACT_7; pfam13840 391616002067 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391616002068 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391616002069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616002070 catalytic loop [active] 391616002071 iron binding site [ion binding]; other site 391616002072 Family description; Region: VCBS; pfam13517 391616002073 cobalamin synthase; Reviewed; Region: cobS; PRK00235 391616002074 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 391616002075 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 391616002076 putative dimer interface [polypeptide binding]; other site 391616002077 active site pocket [active] 391616002078 putative cataytic base [active] 391616002079 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 391616002080 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391616002081 TrkA-N domain; Region: TrkA_N; pfam02254 391616002082 Uncharacterized conserved protein [Function unknown]; Region: COG2968 391616002083 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 391616002084 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 391616002085 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391616002086 homodimer interface [polypeptide binding]; other site 391616002087 substrate-cofactor binding pocket; other site 391616002088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616002089 catalytic residue [active] 391616002090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616002091 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616002092 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002093 MULE transposase domain; Region: MULE; pfam10551 391616002094 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391616002095 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 391616002096 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391616002097 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 391616002098 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 391616002099 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 391616002100 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 391616002101 metal binding site [ion binding]; metal-binding site 391616002102 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 391616002103 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391616002104 substrate binding site [chemical binding]; other site 391616002105 glutamase interaction surface [polypeptide binding]; other site 391616002106 Homeodomain-like domain; Region: HTH_23; pfam13384 391616002107 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002108 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002109 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002110 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391616002111 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391616002112 catalytic residues [active] 391616002113 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 391616002114 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391616002115 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391616002116 putative active site [active] 391616002117 oxyanion strand; other site 391616002118 catalytic triad [active] 391616002119 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391616002120 putative active site pocket [active] 391616002121 4-fold oligomerization interface [polypeptide binding]; other site 391616002122 metal binding residues [ion binding]; metal-binding site 391616002123 3-fold/trimer interface [polypeptide binding]; other site 391616002124 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616002125 Coenzyme A binding pocket [chemical binding]; other site 391616002126 Domain of unknown function (DU1801); Region: DUF1801; cl17490 391616002127 MAPEG family; Region: MAPEG; cl09190 391616002128 Protein of unknown function, DUF481; Region: DUF481; pfam04338 391616002129 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391616002130 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616002131 active site 391616002132 metal binding site [ion binding]; metal-binding site 391616002133 hexamer interface [polypeptide binding]; other site 391616002134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616002135 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391616002136 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 391616002137 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391616002138 putative NAD(P) binding site [chemical binding]; other site 391616002139 pyruvate carboxylase; Reviewed; Region: PRK12999 391616002140 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616002141 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616002142 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391616002143 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 391616002144 active site 391616002145 catalytic residues [active] 391616002146 metal binding site [ion binding]; metal-binding site 391616002147 homodimer binding site [polypeptide binding]; other site 391616002148 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391616002149 carboxyltransferase (CT) interaction site; other site 391616002150 biotinylation site [posttranslational modification]; other site 391616002151 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 391616002152 Part of AAA domain; Region: AAA_19; pfam13245 391616002153 Family description; Region: UvrD_C_2; pfam13538 391616002154 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391616002155 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616002156 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616002157 putative DNA binding site [nucleotide binding]; other site 391616002158 putative Zn2+ binding site [ion binding]; other site 391616002159 AsnC family; Region: AsnC_trans_reg; pfam01037 391616002160 Domain of unknown function DUF59; Region: DUF59; pfam01883 391616002161 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 391616002162 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391616002163 Walker A motif; other site 391616002164 cell division protein MraZ; Reviewed; Region: PRK00326 391616002165 MraZ protein; Region: MraZ; pfam02381 391616002166 MraZ protein; Region: MraZ; pfam02381 391616002167 MraW methylase family; Region: Methyltransf_5; cl17771 391616002168 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 391616002169 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 391616002170 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391616002171 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391616002172 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391616002173 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391616002174 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391616002175 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616002176 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391616002177 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093 391616002178 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391616002179 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616002180 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391616002181 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 391616002182 Mg++ binding site [ion binding]; other site 391616002183 putative catalytic motif [active] 391616002184 putative substrate binding site [chemical binding]; other site 391616002185 Protein of unknown function (DUF3478); Region: DUF3478; pfam11964 391616002186 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616002187 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002188 MULE transposase domain; Region: MULE; pfam10551 391616002189 short chain dehydrogenase; Provisional; Region: PRK06197 391616002190 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 391616002191 putative NAD(P) binding site [chemical binding]; other site 391616002192 active site 391616002193 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616002194 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616002195 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616002196 Integrase core domain; Region: rve; pfam00665 391616002197 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616002198 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616002199 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616002200 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391616002201 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 391616002202 putative active site [active] 391616002203 Zn binding site [ion binding]; other site 391616002204 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002205 MULE transposase domain; Region: MULE; pfam10551 391616002206 Transposase; Region: HTH_Tnp_1; cl17663 391616002207 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616002208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616002209 DNA binding site [nucleotide binding] 391616002210 domain linker motif; other site 391616002211 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391616002212 ligand binding site [chemical binding]; other site 391616002213 dimerization interface [polypeptide binding]; other site 391616002214 Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292 391616002215 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616002216 DctM-like transporters; Region: DctM; pfam06808 391616002217 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391616002218 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391616002219 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616002220 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616002221 Integrase core domain; Region: rve; pfam00665 391616002222 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 391616002223 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391616002224 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391616002225 substrate binding site [chemical binding]; other site 391616002226 ligand binding site [chemical binding]; other site 391616002227 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391616002228 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616002229 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616002230 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391616002231 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391616002232 tetramer interface [polypeptide binding]; other site 391616002233 active site 391616002234 Mg2+/Mn2+ binding site [ion binding]; other site 391616002235 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391616002236 Amidase; Region: Amidase; cl11426 391616002237 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002238 MULE transposase domain; Region: MULE; pfam10551 391616002239 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391616002240 catalytic core [active] 391616002241 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 391616002242 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391616002243 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616002244 catalytic residues [active] 391616002245 catalytic nucleophile [active] 391616002246 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616002247 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616002248 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616002249 Synaptic Site I dimer interface [polypeptide binding]; other site 391616002250 DNA binding site [nucleotide binding] 391616002251 Recombinase; Region: Recombinase; pfam07508 391616002252 ParB-like nuclease domain; Region: ParBc; pfam02195 391616002253 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391616002254 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391616002255 DNA methylase; Region: N6_N4_Mtase; pfam01555 391616002256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616002257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616002258 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391616002259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616002260 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 391616002261 Isochorismatase family; Region: Isochorismatase; pfam00857 391616002262 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391616002263 catalytic triad [active] 391616002264 conserved cis-peptide bond; other site 391616002265 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 391616002266 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 391616002267 [2Fe-2S] cluster binding site [ion binding]; other site 391616002268 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 391616002269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616002270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616002271 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616002272 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 391616002273 iron-sulfur cluster [ion binding]; other site 391616002274 [2Fe-2S] cluster binding site [ion binding]; other site 391616002275 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 391616002276 putative alpha subunit interface [polypeptide binding]; other site 391616002277 putative active site [active] 391616002278 putative substrate binding site [chemical binding]; other site 391616002279 Fe binding site [ion binding]; other site 391616002280 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616002281 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391616002282 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391616002283 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391616002284 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 391616002285 putative hydrophobic ligand binding site [chemical binding]; other site 391616002286 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 391616002287 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391616002288 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391616002289 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616002290 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391616002291 MarR family; Region: MarR_2; cl17246 391616002292 Homeodomain-like domain; Region: HTH_23; pfam13384 391616002293 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002294 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002295 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002297 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002298 Integrase core domain; Region: rve; pfam00665 391616002299 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616002300 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616002301 TM-ABC transporter signature motif; other site 391616002302 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616002303 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616002304 TM-ABC transporter signature motif; other site 391616002305 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391616002306 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616002307 Walker A/P-loop; other site 391616002308 ATP binding site [chemical binding]; other site 391616002309 Q-loop/lid; other site 391616002310 ABC transporter signature motif; other site 391616002311 Walker B; other site 391616002312 D-loop; other site 391616002313 H-loop/switch region; other site 391616002314 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391616002315 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616002316 Walker A/P-loop; other site 391616002317 ATP binding site [chemical binding]; other site 391616002318 Q-loop/lid; other site 391616002319 ABC transporter signature motif; other site 391616002320 Walker B; other site 391616002321 D-loop; other site 391616002322 H-loop/switch region; other site 391616002323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391616002324 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616002325 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391616002326 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391616002327 GYD domain; Region: GYD; cl01743 391616002328 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616002329 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616002330 Walker A motif; other site 391616002331 ATP binding site [chemical binding]; other site 391616002332 Walker B motif; other site 391616002333 arginine finger; other site 391616002334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616002335 Integrase core domain; Region: rve; pfam00665 391616002336 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391616002337 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 391616002338 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391616002339 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616002340 catalytic residues [active] 391616002341 catalytic nucleophile [active] 391616002342 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616002343 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616002344 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616002345 Synaptic Site I dimer interface [polypeptide binding]; other site 391616002346 DNA binding site [nucleotide binding] 391616002347 Recombinase; Region: Recombinase; pfam07508 391616002348 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391616002349 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391616002350 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 391616002351 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391616002352 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 391616002353 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 391616002354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616002355 Walker A/P-loop; other site 391616002356 ATP binding site [chemical binding]; other site 391616002357 Q-loop/lid; other site 391616002358 ABC transporter signature motif; other site 391616002359 Walker B; other site 391616002360 D-loop; other site 391616002361 H-loop/switch region; other site 391616002362 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002363 MULE transposase domain; Region: MULE; pfam10551 391616002364 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 391616002365 putative uracil binding site [chemical binding]; other site 391616002366 putative active site [active] 391616002367 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 391616002368 putative ligand binding site [chemical binding]; other site 391616002369 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391616002370 NAD binding site [chemical binding]; other site 391616002371 dimerization interface [polypeptide binding]; other site 391616002372 catalytic site [active] 391616002373 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 391616002374 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391616002375 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391616002376 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391616002377 rod shape-determining protein MreC; Provisional; Region: PRK13922 391616002378 rod shape-determining protein MreC; Region: MreC; pfam04085 391616002379 rod shape-determining protein MreB; Provisional; Region: PRK13927 391616002380 MreB and similar proteins; Region: MreB_like; cd10225 391616002381 nucleotide binding site [chemical binding]; other site 391616002382 Mg binding site [ion binding]; other site 391616002383 putative protofilament interaction site [polypeptide binding]; other site 391616002384 RodZ interaction site [polypeptide binding]; other site 391616002385 2-isopropylmalate synthase; Validated; Region: PRK00915 391616002386 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 391616002387 active site 391616002388 catalytic residues [active] 391616002389 metal binding site [ion binding]; metal-binding site 391616002390 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391616002391 C factor cell-cell signaling protein; Provisional; Region: PRK09009 391616002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616002393 NAD(P) binding site [chemical binding]; other site 391616002394 active site 391616002395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616002396 Coenzyme A binding pocket [chemical binding]; other site 391616002397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616002398 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616002399 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616002400 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002401 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002402 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002403 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002404 PAS domain; Region: PAS_9; pfam13426 391616002405 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 391616002406 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391616002407 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391616002408 metal binding site [ion binding]; metal-binding site 391616002409 active site 391616002410 I-site; other site 391616002411 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616002412 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 391616002413 Integrase core domain; Region: rve; pfam00665 391616002414 Integrase core domain; Region: rve_3; pfam13683 391616002415 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391616002416 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 391616002417 putative ADP-binding pocket [chemical binding]; other site 391616002418 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 391616002419 Putative phosphatase (DUF442); Region: DUF442; cl17385 391616002420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391616002421 putative acyl-acceptor binding pocket; other site 391616002422 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391616002423 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391616002424 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616002425 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616002426 Integrase core domain; Region: rve; pfam00665 391616002427 Integrase core domain; Region: rve_3; pfam13683 391616002428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616002429 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616002430 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616002431 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391616002432 DctM-like transporters; Region: DctM; pfam06808 391616002433 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391616002434 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391616002435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616002436 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616002437 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391616002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616002439 dimer interface [polypeptide binding]; other site 391616002440 conserved gate region; other site 391616002441 putative PBP binding loops; other site 391616002442 ABC-ATPase subunit interface; other site 391616002443 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391616002444 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616002445 Walker A/P-loop; other site 391616002446 ATP binding site [chemical binding]; other site 391616002447 Q-loop/lid; other site 391616002448 ABC transporter signature motif; other site 391616002449 Walker B; other site 391616002450 D-loop; other site 391616002451 H-loop/switch region; other site 391616002452 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 391616002453 PBP superfamily domain; Region: PBP_like_2; pfam12849 391616002454 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391616002455 antiporter inner membrane protein; Provisional; Region: PRK11670 391616002456 Domain of unknown function DUF59; Region: DUF59; pfam01883 391616002457 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391616002458 Walker A motif; other site 391616002459 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391616002460 4Fe-4S binding domain; Region: Fer4; pfam00037 391616002461 4Fe-4S binding domain; Region: Fer4; pfam00037 391616002462 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 391616002463 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 391616002464 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 391616002465 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 391616002466 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 391616002467 [4Fe-4S] binding site [ion binding]; other site 391616002468 molybdopterin cofactor binding site; other site 391616002469 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391616002470 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391616002471 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 391616002472 molybdopterin cofactor binding site; other site 391616002473 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 391616002474 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 391616002475 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 391616002476 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 391616002477 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391616002478 dimer interface [polypeptide binding]; other site 391616002479 putative functional site; other site 391616002480 putative MPT binding site; other site 391616002481 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 391616002482 Walker A motif; other site 391616002483 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391616002484 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391616002485 GTP binding site; other site 391616002486 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 391616002487 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616002488 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616002489 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 391616002490 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 391616002491 putative dimer interface [polypeptide binding]; other site 391616002492 [2Fe-2S] cluster binding site [ion binding]; other site 391616002493 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 391616002494 SLBB domain; Region: SLBB; pfam10531 391616002495 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391616002496 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391616002497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616002498 catalytic loop [active] 391616002499 iron binding site [ion binding]; other site 391616002500 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 391616002501 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391616002502 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 391616002503 [4Fe-4S] binding site [ion binding]; other site 391616002504 molybdopterin cofactor binding site; other site 391616002505 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 391616002506 molybdopterin cofactor binding site; other site 391616002507 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 391616002508 Integrase core domain; Region: rve; pfam00665 391616002509 Integrase core domain; Region: rve_3; pfam13683 391616002510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616002511 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616002512 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616002513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616002514 Transposase; Region: HTH_Tnp_1; cl17663 391616002515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616002516 Integrase core domain; Region: rve; pfam00665 391616002517 Integrase core domain; Region: rve_3; pfam13683 391616002518 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616002519 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391616002520 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391616002521 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616002522 Integrase core domain; Region: rve; pfam00665 391616002523 Integrase core domain; Region: rve; pfam00665 391616002524 Integrase core domain; Region: rve_3; pfam13683 391616002525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616002526 Integrase core domain; Region: rve; pfam00665 391616002527 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616002528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616002529 Walker A motif; other site 391616002530 ATP binding site [chemical binding]; other site 391616002531 Walker B motif; other site 391616002532 arginine finger; other site 391616002533 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616002534 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616002535 Integrase core domain; Region: rve; pfam00665 391616002536 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616002537 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616002538 Integrase core domain; Region: rve; pfam00665 391616002539 flagellin; Provisional; Region: PRK12804 391616002540 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391616002541 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391616002542 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002543 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002544 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002545 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002546 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616002547 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002548 MULE transposase domain; Region: MULE; pfam10551 391616002549 Type IV secretion system proteins; Region: T4SS; pfam07996 391616002550 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391616002551 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616002552 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616002553 catalytic residue [active] 391616002554 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 391616002555 TrbC/VIRB2 family; Region: TrbC; pfam04956 391616002556 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616002557 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391616002558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616002559 catalytic residue [active] 391616002560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616002561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616002562 non-specific DNA binding site [nucleotide binding]; other site 391616002563 salt bridge; other site 391616002564 sequence-specific DNA binding site [nucleotide binding]; other site 391616002565 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616002566 active site 391616002567 catalytic residues [active] 391616002568 DNA binding site [nucleotide binding] 391616002569 Int/Topo IB signature motif; other site 391616002570 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 391616002571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616002572 S-adenosylmethionine binding site [chemical binding]; other site 391616002573 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391616002574 cobyric acid synthase; Provisional; Region: PRK00784 391616002575 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 391616002576 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391616002577 catalytic triad [active] 391616002578 elongation factor P; Validated; Region: PRK00529 391616002579 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391616002580 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 391616002581 RNA binding site [nucleotide binding]; other site 391616002582 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 391616002583 RNA binding site [nucleotide binding]; other site 391616002584 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 391616002585 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391616002586 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616002587 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616002588 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616002589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616002590 Walker A/P-loop; other site 391616002591 ATP binding site [chemical binding]; other site 391616002592 Q-loop/lid; other site 391616002593 ABC transporter signature motif; other site 391616002594 Walker B; other site 391616002595 D-loop; other site 391616002596 H-loop/switch region; other site 391616002597 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 391616002598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616002599 catalytic residue [active] 391616002600 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 391616002601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616002602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616002603 homodimer interface [polypeptide binding]; other site 391616002604 catalytic residue [active] 391616002605 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 391616002606 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391616002607 HIGH motif; other site 391616002608 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391616002609 active site 391616002610 KMSKS motif; other site 391616002611 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391616002612 tRNA binding surface [nucleotide binding]; other site 391616002613 anticodon binding site; other site 391616002614 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391616002615 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391616002616 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391616002617 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616002618 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391616002619 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 391616002620 FAD binding site [chemical binding]; other site 391616002621 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 391616002622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616002623 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 391616002624 putative dimerization interface [polypeptide binding]; other site 391616002625 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616002626 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391616002627 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391616002628 active site 391616002629 dimerization interface [polypeptide binding]; other site 391616002630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616002631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391616002632 active site 391616002633 metal binding site [ion binding]; metal-binding site 391616002634 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391616002635 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 391616002636 Proline dehydrogenase; Region: Pro_dh; pfam01619 391616002637 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 391616002638 Glutamate binding site [chemical binding]; other site 391616002639 NAD binding site [chemical binding]; other site 391616002640 catalytic residues [active] 391616002641 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616002642 NAD(P) binding site [chemical binding]; other site 391616002643 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 391616002644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616002645 putative DNA binding site [nucleotide binding]; other site 391616002646 putative Zn2+ binding site [ion binding]; other site 391616002647 AsnC family; Region: AsnC_trans_reg; pfam01037 391616002648 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391616002649 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616002650 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616002651 catalytic residue [active] 391616002652 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 391616002653 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391616002654 active site 391616002655 HIGH motif; other site 391616002656 KMSKS motif; other site 391616002657 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391616002658 tRNA binding surface [nucleotide binding]; other site 391616002659 anticodon binding site; other site 391616002660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616002661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616002662 putative substrate translocation pore; other site 391616002663 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616002664 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616002665 active site 391616002666 catalytic tetrad [active] 391616002667 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002668 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002669 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002671 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 391616002672 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 391616002673 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 391616002674 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616002675 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616002676 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616002677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616002678 Coenzyme A binding pocket [chemical binding]; other site 391616002679 Uncharacterized conserved protein [Function unknown]; Region: COG3246 391616002680 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 391616002681 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002682 Integrase core domain; Region: rve; pfam00665 391616002683 Integrase core domain; Region: rve_3; pfam13683 391616002684 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 391616002685 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391616002686 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391616002687 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391616002688 active site 391616002689 short chain dehydrogenase; Provisional; Region: PRK12829 391616002690 classical (c) SDRs; Region: SDR_c; cd05233 391616002691 NAD(P) binding site [chemical binding]; other site 391616002692 active site 391616002693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616002694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616002695 sequence-specific DNA binding site [nucleotide binding]; other site 391616002696 salt bridge; other site 391616002697 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391616002698 putative di-iron ligands [ion binding]; other site 391616002699 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 391616002700 nudix motif; other site 391616002701 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391616002702 Ca2+ binding site [ion binding]; other site 391616002703 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616002704 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391616002705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616002706 DNA binding residues [nucleotide binding] 391616002707 Heavy-metal resistance; Region: Metal_resist; pfam13801 391616002708 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391616002709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616002710 active site 391616002711 phosphorylation site [posttranslational modification] 391616002712 intermolecular recognition site; other site 391616002713 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 391616002714 dimerization interface [polypeptide binding]; other site 391616002715 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391616002716 metal binding site [ion binding]; metal-binding site 391616002717 active site 391616002718 I-site; other site 391616002719 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 391616002720 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391616002721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616002722 motif II; other site 391616002723 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391616002724 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 391616002725 metal binding site 2 [ion binding]; metal-binding site 391616002726 putative DNA binding helix; other site 391616002727 metal binding site 1 [ion binding]; metal-binding site 391616002728 dimer interface [polypeptide binding]; other site 391616002729 structural Zn2+ binding site [ion binding]; other site 391616002730 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 391616002731 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391616002732 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391616002733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391616002734 ABC-ATPase subunit interface; other site 391616002735 dimer interface [polypeptide binding]; other site 391616002736 putative PBP binding regions; other site 391616002737 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 391616002738 putative active site [active] 391616002739 dimerization interface [polypeptide binding]; other site 391616002740 putative tRNAtyr binding site [nucleotide binding]; other site 391616002741 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616002742 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 391616002743 putative substrate binding site [chemical binding]; other site 391616002744 putative ATP binding site [chemical binding]; other site 391616002745 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 391616002746 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 391616002747 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391616002748 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 391616002749 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 391616002750 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391616002751 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616002752 RNA binding surface [nucleotide binding]; other site 391616002753 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391616002754 active site 391616002755 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391616002756 nucleoside/Zn binding site; other site 391616002757 dimer interface [polypeptide binding]; other site 391616002758 catalytic motif [active] 391616002759 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 391616002760 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391616002761 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 391616002762 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 391616002763 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391616002764 amidase catalytic site [active] 391616002765 Zn binding residues [ion binding]; other site 391616002766 substrate binding site [chemical binding]; other site 391616002767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616002768 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616002769 active site 391616002770 catalytic tetrad [active] 391616002771 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 391616002772 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616002775 Coenzyme A binding pocket [chemical binding]; other site 391616002776 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 391616002777 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 391616002778 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391616002779 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616002780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616002781 dimerization interface [polypeptide binding]; other site 391616002782 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391616002783 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391616002784 NAD(P) binding site [chemical binding]; other site 391616002785 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616002786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616002787 non-specific DNA binding site [nucleotide binding]; other site 391616002788 salt bridge; other site 391616002789 sequence-specific DNA binding site [nucleotide binding]; other site 391616002790 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391616002791 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391616002792 active site 391616002793 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616002794 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616002795 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616002796 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391616002797 seryl-tRNA synthetase; Provisional; Region: PRK05431 391616002798 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 391616002799 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 391616002800 dimer interface [polypeptide binding]; other site 391616002801 active site 391616002802 motif 1; other site 391616002803 motif 2; other site 391616002804 motif 3; other site 391616002805 Preprotein translocase subunit; Region: YajC; pfam02699 391616002806 bifunctional preprotein translocase subunit SecD/SecF; Provisional; Region: PRK14726 391616002807 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 391616002808 Protein export membrane protein; Region: SecD_SecF; pfam02355 391616002809 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 391616002810 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 391616002811 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616002812 Walker A/P-loop; other site 391616002813 ATP binding site [chemical binding]; other site 391616002814 Q-loop/lid; other site 391616002815 ABC transporter signature motif; other site 391616002816 Walker B; other site 391616002817 D-loop; other site 391616002818 H-loop/switch region; other site 391616002819 heme exporter protein CcmB; Region: ccmB; TIGR01190 391616002820 heme exporter protein CcmC; Region: ccmC; TIGR01191 391616002821 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 391616002822 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 391616002823 catalytic residues [active] 391616002824 central insert; other site 391616002825 Amidinotransferase; Region: Amidinotransf; cl12043 391616002826 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391616002827 aconitate hydratase; Validated; Region: PRK09277 391616002828 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 391616002829 substrate binding site [chemical binding]; other site 391616002830 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391616002831 ligand binding site [chemical binding]; other site 391616002832 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 391616002833 substrate binding site [chemical binding]; other site 391616002834 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 391616002835 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391616002836 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391616002837 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391616002838 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391616002839 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391616002840 FliG C-terminal domain; Region: FliG_C; pfam01706 391616002841 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391616002842 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391616002843 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391616002844 DNA binding residues [nucleotide binding] 391616002845 dimerization interface [polypeptide binding]; other site 391616002846 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002847 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002848 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002850 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002851 MULE transposase domain; Region: MULE; pfam10551 391616002852 adenylosuccinate lyase; Provisional; Region: PRK07492 391616002853 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 391616002854 tetramer interface [polypeptide binding]; other site 391616002855 active site 391616002856 BioY family; Region: BioY; pfam02632 391616002857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616002858 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391616002859 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 391616002860 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391616002861 putative catalytic site [active] 391616002862 putative metal binding site [ion binding]; other site 391616002863 putative phosphate binding site [ion binding]; other site 391616002864 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616002865 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616002866 active site 391616002867 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391616002868 glutamine synthetase; Provisional; Region: glnA; PRK09469 391616002869 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391616002870 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391616002871 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391616002872 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391616002873 Hint domain; Region: Hint_2; pfam13403 391616002874 trigger factor; Provisional; Region: tig; PRK01490 391616002875 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391616002876 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391616002877 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002878 Homeodomain-like domain; Region: HTH_32; pfam13565 391616002879 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002880 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002881 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002882 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616002883 MULE transposase domain; Region: MULE; pfam10551 391616002884 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 391616002885 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391616002886 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391616002887 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 391616002888 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 391616002889 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391616002890 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391616002891 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391616002892 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391616002893 NAD(P) binding site [chemical binding]; other site 391616002894 homotetramer interface [polypeptide binding]; other site 391616002895 homodimer interface [polypeptide binding]; other site 391616002896 active site 391616002897 acyl carrier protein; Provisional; Region: acpP; PRK00982 391616002898 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 391616002899 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391616002900 dimer interface [polypeptide binding]; other site 391616002901 active site 391616002902 YceG-like family; Region: YceG; pfam02618 391616002903 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 391616002904 dimerization interface [polypeptide binding]; other site 391616002905 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002906 Homeodomain-like domain; Region: HTH_32; pfam13565 391616002907 Winged helix-turn helix; Region: HTH_33; pfam13592 391616002908 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616002909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616002910 Phage-related protein [Function unknown]; Region: COG4695 391616002911 Phage portal protein; Region: Phage_portal; pfam04860 391616002912 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 391616002913 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 391616002914 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391616002915 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391616002916 oligomerization interface [polypeptide binding]; other site 391616002917 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 391616002918 Phage major tail protein 2; Region: Phage_tail_2; cl11463 391616002919 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 391616002920 phage conserved hypothetical protein; Region: phage_TIGR02216 391616002921 Phage-related minor tail protein [Function unknown]; Region: COG5281 391616002922 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 391616002923 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 391616002924 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 391616002925 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 391616002926 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391616002927 NlpC/P60 family; Region: NLPC_P60; cl17555 391616002928 Winged helix-turn helix; Region: HTH_29; pfam13551 391616002929 Integrase core domain; Region: rve; pfam00665 391616002930 Integrase core domain; Region: rve_3; pfam13683 391616002931 serine acetyltransferase; Provisional; Region: cysE; PRK11132 391616002932 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 391616002933 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 391616002934 trimer interface [polypeptide binding]; other site 391616002935 active site 391616002936 substrate binding site [chemical binding]; other site 391616002937 CoA binding site [chemical binding]; other site 391616002938 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 391616002939 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616002940 E3 interaction surface; other site 391616002941 lipoyl attachment site [posttranslational modification]; other site 391616002942 e3 binding domain; Region: E3_binding; pfam02817 391616002943 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391616002944 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 391616002945 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616002946 E3 interaction surface; other site 391616002947 lipoyl attachment site [posttranslational modification]; other site 391616002948 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391616002949 alpha subunit interface [polypeptide binding]; other site 391616002950 TPP binding site [chemical binding]; other site 391616002951 heterodimer interface [polypeptide binding]; other site 391616002952 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616002953 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391616002954 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391616002955 tetramer interface [polypeptide binding]; other site 391616002956 TPP-binding site [chemical binding]; other site 391616002957 heterodimer interface [polypeptide binding]; other site 391616002958 phosphorylation loop region [posttranslational modification] 391616002959 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391616002960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616002961 Coenzyme A binding pocket [chemical binding]; other site 391616002962 Septum formation initiator; Region: DivIC; cl17659 391616002963 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 391616002964 catalytic residue [active] 391616002965 Phosphoglycerate kinase; Region: PGK; pfam00162 391616002966 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 391616002967 substrate binding site [chemical binding]; other site 391616002968 hinge regions; other site 391616002969 ADP binding site [chemical binding]; other site 391616002970 catalytic site [active] 391616002971 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391616002972 active site 391616002973 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391616002974 active site 391616002975 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 391616002976 hypothetical protein; Validated; Region: PRK00029 391616002977 Uncharacterized conserved protein [Function unknown]; Region: COG0397 391616002978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616002979 FOG: CBS domain [General function prediction only]; Region: COG0517 391616002980 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391616002981 Transposase; Region: HTH_Tnp_1; cl17663 391616002982 acyl-CoA synthetase; Validated; Region: PRK08162 391616002983 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391616002984 acyl-activating enzyme (AAE) consensus motif; other site 391616002985 putative active site [active] 391616002986 AMP binding site [chemical binding]; other site 391616002987 putative CoA binding site [chemical binding]; other site 391616002988 enoyl-CoA hydratase; Validated; Region: PRK08139 391616002989 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616002990 substrate binding site [chemical binding]; other site 391616002991 oxyanion hole (OAH) forming residues; other site 391616002992 trimer interface [polypeptide binding]; other site 391616002993 OsmC-like protein; Region: OsmC; pfam02566 391616002994 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391616002995 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616002996 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616002997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616002998 putative DNA binding site [nucleotide binding]; other site 391616002999 putative Zn2+ binding site [ion binding]; other site 391616003000 AsnC family; Region: AsnC_trans_reg; pfam01037 391616003001 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391616003002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616003003 active site 391616003004 phosphorylation site [posttranslational modification] 391616003005 intermolecular recognition site; other site 391616003006 dimerization interface [polypeptide binding]; other site 391616003007 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391616003008 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391616003009 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391616003010 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 391616003011 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616003012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616003013 dimer interface [polypeptide binding]; other site 391616003014 conserved gate region; other site 391616003015 putative PBP binding loops; other site 391616003016 ABC-ATPase subunit interface; other site 391616003017 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616003018 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616003019 Walker A/P-loop; other site 391616003020 ATP binding site [chemical binding]; other site 391616003021 Q-loop/lid; other site 391616003022 ABC transporter signature motif; other site 391616003023 Walker B; other site 391616003024 D-loop; other site 391616003025 H-loop/switch region; other site 391616003026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616003027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616003028 substrate binding pocket [chemical binding]; other site 391616003029 membrane-bound complex binding site; other site 391616003030 hinge residues; other site 391616003031 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616003032 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391616003033 C-terminal domain interface [polypeptide binding]; other site 391616003034 GSH binding site (G-site) [chemical binding]; other site 391616003035 dimer interface [polypeptide binding]; other site 391616003036 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003037 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616003038 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003039 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391616003040 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391616003041 ATP binding site [chemical binding]; other site 391616003042 Mg++ binding site [ion binding]; other site 391616003043 motif III; other site 391616003044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616003045 nucleotide binding region [chemical binding]; other site 391616003046 ATP-binding site [chemical binding]; other site 391616003047 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 391616003048 RNA binding site [nucleotide binding]; other site 391616003049 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391616003050 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 391616003051 NodB motif; other site 391616003052 active site 391616003053 metal binding site [ion binding]; metal-binding site 391616003054 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616003055 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 391616003056 Hint domain; Region: Hint_2; pfam13403 391616003057 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 391616003058 active site triad [active] 391616003059 hypothetical protein; Validated; Region: PRK09104 391616003060 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 391616003061 metal binding site [ion binding]; metal-binding site 391616003062 putative dimer interface [polypeptide binding]; other site 391616003063 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391616003064 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391616003065 substrate-cofactor binding pocket; other site 391616003066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616003067 catalytic residue [active] 391616003068 Helix-turn-helix domain; Region: HTH_25; pfam13413 391616003069 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 391616003070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391616003071 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391616003072 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391616003073 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 391616003074 catalytic residues [active] 391616003075 Peptidase family M48; Region: Peptidase_M48; cl12018 391616003076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391616003077 binding surface 391616003078 TPR motif; other site 391616003079 TPR repeat; Region: TPR_11; pfam13414 391616003080 aspartate aminotransferase; Provisional; Region: PRK05764 391616003081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616003082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616003083 homodimer interface [polypeptide binding]; other site 391616003084 catalytic residue [active] 391616003085 AMIN domain; Region: AMIN; pfam11741 391616003086 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 391616003087 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391616003088 active site 391616003089 metal binding site [ion binding]; metal-binding site 391616003090 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391616003091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616003092 S-adenosylmethionine binding site [chemical binding]; other site 391616003093 Leucine carboxyl methyltransferase; Region: LCM; cl01306 391616003094 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 391616003095 Transglycosylase; Region: Transgly; pfam00912 391616003096 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391616003097 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391616003098 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391616003099 RF-1 domain; Region: RF-1; pfam00472 391616003100 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616003101 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391616003102 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391616003103 Peptidase family M23; Region: Peptidase_M23; pfam01551 391616003104 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391616003105 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391616003106 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391616003107 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 391616003108 catalytic triad [active] 391616003109 Protein of unknown function; Region: DUF3971; pfam13116 391616003110 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391616003111 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 391616003112 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 391616003113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616003114 putative MFS family transporter protein; Provisional; Region: PRK03633 391616003115 putative substrate translocation pore; other site 391616003116 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 391616003117 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003119 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003120 Homeodomain-like domain; Region: HTH_32; pfam13565 391616003121 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003122 PAS fold; Region: PAS_7; pfam12860 391616003123 GAF domain; Region: GAF_3; pfam13492 391616003124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616003125 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616003126 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391616003127 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391616003128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616003129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616003130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616003131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616003132 putative substrate translocation pore; other site 391616003133 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391616003134 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391616003135 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391616003136 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 391616003137 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616003138 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391616003139 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 391616003140 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616003141 substrate binding site [chemical binding]; other site 391616003142 oxyanion hole (OAH) forming residues; other site 391616003143 trimer interface [polypeptide binding]; other site 391616003144 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 391616003145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616003146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391616003147 active site 391616003148 carboxylate-amine ligase; Provisional; Region: PRK13515 391616003149 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 391616003150 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391616003151 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 391616003152 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 391616003153 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391616003154 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 391616003155 tetrameric interface [polypeptide binding]; other site 391616003156 NAD binding site [chemical binding]; other site 391616003157 catalytic residues [active] 391616003158 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616003159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616003160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616003161 dimerization interface [polypeptide binding]; other site 391616003162 FOG: CBS domain [General function prediction only]; Region: COG0517 391616003163 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391616003164 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 391616003165 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391616003166 active site 391616003167 (T/H)XGH motif; other site 391616003168 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616003169 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391616003170 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391616003171 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391616003172 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391616003173 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391616003174 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391616003175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 391616003176 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 391616003177 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391616003178 TPP-binding site [chemical binding]; other site 391616003179 dimer interface [polypeptide binding]; other site 391616003180 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391616003181 PYR/PP interface [polypeptide binding]; other site 391616003182 dimer interface [polypeptide binding]; other site 391616003183 TPP binding site [chemical binding]; other site 391616003184 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616003185 Cell division protein ZapA; Region: ZapA; pfam05164 391616003186 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 391616003187 putative GSH binding site [chemical binding]; other site 391616003188 catalytic residues [active] 391616003189 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391616003190 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 391616003191 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 391616003192 dimerization interface [polypeptide binding]; other site 391616003193 ATP binding site [chemical binding]; other site 391616003194 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 391616003195 dimerization interface [polypeptide binding]; other site 391616003196 ATP binding site [chemical binding]; other site 391616003197 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616003198 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616003199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616003200 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616003201 putative effector binding pocket; other site 391616003202 dimerization interface [polypeptide binding]; other site 391616003203 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391616003204 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391616003205 dimer interface [polypeptide binding]; other site 391616003206 PYR/PP interface [polypeptide binding]; other site 391616003207 TPP binding site [chemical binding]; other site 391616003208 substrate binding site [chemical binding]; other site 391616003209 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391616003210 TPP-binding site [chemical binding]; other site 391616003211 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391616003212 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391616003213 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 391616003214 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391616003215 CcmE; Region: CcmE; pfam03100 391616003216 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 391616003217 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 391616003218 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 391616003219 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 391616003220 enoyl-CoA hydratase; Provisional; Region: PRK08140 391616003221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616003222 substrate binding site [chemical binding]; other site 391616003223 oxyanion hole (OAH) forming residues; other site 391616003224 trimer interface [polypeptide binding]; other site 391616003225 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616003226 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003227 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003228 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003229 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391616003231 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616003232 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391616003233 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391616003234 dimer interface [polypeptide binding]; other site 391616003235 active site 391616003236 citrylCoA binding site [chemical binding]; other site 391616003237 NADH binding [chemical binding]; other site 391616003238 cationic pore residues; other site 391616003239 oxalacetate/citrate binding site [chemical binding]; other site 391616003240 coenzyme A binding site [chemical binding]; other site 391616003241 catalytic triad [active] 391616003242 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391616003243 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616003244 active site 391616003245 HIGH motif; other site 391616003246 nucleotide binding site [chemical binding]; other site 391616003247 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391616003248 active site 391616003249 KMSKS motif; other site 391616003250 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003251 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003252 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003253 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616003254 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003255 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003256 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003257 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003258 LexA repressor; Validated; Region: PRK00215 391616003259 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 391616003260 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391616003261 Catalytic site [active] 391616003262 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391616003263 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391616003264 dimer interface [polypeptide binding]; other site 391616003265 putative functional site; other site 391616003266 putative MPT binding site; other site 391616003267 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 391616003268 trimer interface [polypeptide binding]; other site 391616003269 dimer interface [polypeptide binding]; other site 391616003270 putative active site [active] 391616003271 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391616003272 active site 391616003273 ribulose/triose binding site [chemical binding]; other site 391616003274 phosphate binding site [ion binding]; other site 391616003275 substrate (anthranilate) binding pocket [chemical binding]; other site 391616003276 product (indole) binding pocket [chemical binding]; other site 391616003277 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616003278 Integrase core domain; Region: rve_3; pfam13683 391616003279 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616003280 Transposase; Region: HTH_Tnp_1; cl17663 391616003281 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003282 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391616003283 oligomerisation interface [polypeptide binding]; other site 391616003284 mobile loop; other site 391616003285 roof hairpin; other site 391616003286 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391616003287 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391616003288 ring oligomerisation interface [polypeptide binding]; other site 391616003289 ATP/Mg binding site [chemical binding]; other site 391616003290 stacking interactions; other site 391616003291 hinge regions; other site 391616003292 HTH-like domain; Region: HTH_21; pfam13276 391616003293 Integrase core domain; Region: rve; pfam00665 391616003294 Integrase core domain; Region: rve_3; pfam13683 391616003295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616003296 active site 391616003297 DNA binding site [nucleotide binding] 391616003298 Int/Topo IB signature motif; other site 391616003299 AAA domain; Region: AAA_25; pfam13481 391616003300 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391616003301 Walker A motif; other site 391616003302 ATP binding site [chemical binding]; other site 391616003303 Walker B motif; other site 391616003304 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616003305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616003306 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616003307 Integrase core domain; Region: rve; pfam00665 391616003308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391616003309 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391616003310 DNA binding residues [nucleotide binding] 391616003311 dimerization interface [polypeptide binding]; other site 391616003312 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391616003313 cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976 391616003314 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616003315 catalytic residue [active] 391616003316 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616003317 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616003318 substrate binding pocket [chemical binding]; other site 391616003319 membrane-bound complex binding site; other site 391616003320 hinge residues; other site 391616003321 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616003323 dimer interface [polypeptide binding]; other site 391616003324 conserved gate region; other site 391616003325 putative PBP binding loops; other site 391616003326 ABC-ATPase subunit interface; other site 391616003327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616003328 dimer interface [polypeptide binding]; other site 391616003329 conserved gate region; other site 391616003330 putative PBP binding loops; other site 391616003331 ABC-ATPase subunit interface; other site 391616003332 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616003333 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616003334 Walker A/P-loop; other site 391616003335 ATP binding site [chemical binding]; other site 391616003336 Q-loop/lid; other site 391616003337 ABC transporter signature motif; other site 391616003338 Walker B; other site 391616003339 D-loop; other site 391616003340 H-loop/switch region; other site 391616003341 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391616003342 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391616003343 active site 391616003344 Predicted esterase [General function prediction only]; Region: COG0400 391616003345 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391616003346 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391616003347 Protein of unknown function (DUF3604); Region: DUF3604; pfam12228 391616003348 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391616003349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391616003350 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616003351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616003352 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616003353 dimerization interface [polypeptide binding]; other site 391616003354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391616003355 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391616003356 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 391616003357 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391616003358 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 391616003359 putative active site pocket [active] 391616003360 putative metal binding site [ion binding]; other site 391616003361 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391616003362 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391616003363 inhibitor site; inhibition site 391616003364 active site 391616003365 dimer interface [polypeptide binding]; other site 391616003366 catalytic residue [active] 391616003367 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391616003368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616003369 DNA-binding site [nucleotide binding]; DNA binding site 391616003370 FCD domain; Region: FCD; pfam07729 391616003371 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 391616003372 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391616003373 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391616003374 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 391616003375 dimer interface [polypeptide binding]; other site 391616003376 NADP binding site [chemical binding]; other site 391616003377 catalytic residues [active] 391616003378 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003379 MULE transposase domain; Region: MULE; pfam10551 391616003380 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616003382 Walker A motif; other site 391616003383 ATP binding site [chemical binding]; other site 391616003384 Walker B motif; other site 391616003385 arginine finger; other site 391616003386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616003387 Integrase core domain; Region: rve; pfam00665 391616003388 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391616003389 HAMP domain; Region: HAMP; pfam00672 391616003390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616003391 ATP binding site [chemical binding]; other site 391616003392 Mg2+ binding site [ion binding]; other site 391616003393 G-X-G motif; other site 391616003394 Cation transport protein; Region: TrkH; cl17365 391616003395 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391616003396 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391616003397 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391616003398 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 391616003399 dimerization interface [polypeptide binding]; other site 391616003400 putative ATP binding site [chemical binding]; other site 391616003401 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391616003402 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391616003403 active site 391616003404 substrate binding site [chemical binding]; other site 391616003405 cosubstrate binding site; other site 391616003406 catalytic site [active] 391616003407 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391616003408 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391616003409 catalytic site [active] 391616003410 putative active site [active] 391616003411 putative substrate binding site [chemical binding]; other site 391616003412 HRDC domain; Region: HRDC; pfam00570 391616003413 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 391616003414 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 391616003415 glutathionine S-transferase; Provisional; Region: PRK10542 391616003416 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616003417 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 391616003418 dimer interface [polypeptide binding]; other site 391616003419 N-terminal domain interface [polypeptide binding]; other site 391616003420 substrate binding pocket (H-site) [chemical binding]; other site 391616003421 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 391616003422 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 391616003423 B12 binding site [chemical binding]; other site 391616003424 cobalt ligand [ion binding]; other site 391616003425 methionine synthase I; Validated; Region: PRK07534 391616003426 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391616003427 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 391616003428 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 391616003429 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 391616003430 ATP binding site [chemical binding]; other site 391616003431 active site 391616003432 substrate binding site [chemical binding]; other site 391616003433 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 391616003434 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 391616003435 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391616003436 putative active site [active] 391616003437 catalytic triad [active] 391616003438 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391616003439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616003440 dimer interface [polypeptide binding]; other site 391616003441 phosphorylation site [posttranslational modification] 391616003442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616003443 ATP binding site [chemical binding]; other site 391616003444 Mg2+ binding site [ion binding]; other site 391616003445 G-X-G motif; other site 391616003446 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391616003447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616003448 active site 391616003449 phosphorylation site [posttranslational modification] 391616003450 intermolecular recognition site; other site 391616003451 dimerization interface [polypeptide binding]; other site 391616003452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616003453 Walker A motif; other site 391616003454 ATP binding site [chemical binding]; other site 391616003455 Walker B motif; other site 391616003456 arginine finger; other site 391616003457 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391616003458 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391616003459 putative catalytic site [active] 391616003460 putative phosphate binding site [ion binding]; other site 391616003461 putative metal binding site [ion binding]; other site 391616003462 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391616003463 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391616003464 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391616003465 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391616003466 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391616003467 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391616003468 Cytochrome P450; Region: p450; cl12078 391616003469 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391616003470 Class II fumarases; Region: Fumarase_classII; cd01362 391616003471 active site 391616003472 tetramer interface [polypeptide binding]; other site 391616003473 Stringent starvation protein B; Region: SspB; pfam04386 391616003474 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 391616003475 Chromate transporter; Region: Chromate_transp; pfam02417 391616003476 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616003477 active site residue [active] 391616003478 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 391616003479 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391616003480 Cytochrome P450; Region: p450; cl12078 391616003481 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391616003482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616003483 dimer interface [polypeptide binding]; other site 391616003484 phosphorylation site [posttranslational modification] 391616003485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616003486 ATP binding site [chemical binding]; other site 391616003487 Mg2+ binding site [ion binding]; other site 391616003488 G-X-G motif; other site 391616003489 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391616003490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616003491 active site 391616003492 phosphorylation site [posttranslational modification] 391616003493 intermolecular recognition site; other site 391616003494 dimerization interface [polypeptide binding]; other site 391616003495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391616003496 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391616003497 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616003498 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391616003499 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391616003500 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391616003501 DctM-like transporters; Region: DctM; pfam06808 391616003502 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616003503 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616003504 triosephosphate isomerase; Provisional; Region: PRK14565 391616003505 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391616003506 substrate binding site [chemical binding]; other site 391616003507 dimer interface [polypeptide binding]; other site 391616003508 catalytic triad [active] 391616003509 oxidase reductase; Provisional; Region: PTZ00273 391616003510 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 391616003511 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 391616003512 TfoX N-terminal domain; Region: TfoX_N; pfam04993 391616003513 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391616003514 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 391616003515 MarR family; Region: MarR_2; cl17246 391616003516 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 391616003517 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 391616003518 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 391616003519 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616003520 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 391616003521 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 391616003522 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391616003523 Found in ATP-dependent protease La (LON); Region: LON; smart00464 391616003524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616003525 Walker A motif; other site 391616003526 ATP binding site [chemical binding]; other site 391616003527 Walker B motif; other site 391616003528 arginine finger; other site 391616003529 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391616003530 HTH-like domain; Region: HTH_21; pfam13276 391616003531 Integrase core domain; Region: rve; pfam00665 391616003532 Integrase core domain; Region: rve_2; pfam13333 391616003533 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003534 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003535 D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409 391616003536 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391616003537 catalytic core [active] 391616003538 Integrase core domain; Region: rve; pfam00665 391616003539 Integrase core domain; Region: rve_3; pfam13683 391616003540 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003541 Integrase core domain; Region: rve; pfam00665 391616003542 Integrase core domain; Region: rve_3; pfam13683 391616003543 Transposase; Region: HTH_Tnp_1; cl17663 391616003544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003545 HTH-like domain; Region: HTH_21; pfam13276 391616003546 Integrase core domain; Region: rve; pfam00665 391616003547 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391616003548 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391616003549 putative acyl-acceptor binding pocket; other site 391616003550 Integrase core domain; Region: rve; pfam00665 391616003551 Integrase core domain; Region: rve_3; pfam13683 391616003552 Integrase core domain; Region: rve; pfam00665 391616003553 Integrase core domain; Region: rve_3; pfam13683 391616003554 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003555 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003556 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 391616003557 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391616003558 putative ligand binding site [chemical binding]; other site 391616003559 putative NAD binding site [chemical binding]; other site 391616003560 catalytic site [active] 391616003561 EamA-like transporter family; Region: EamA; pfam00892 391616003562 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616003563 EamA-like transporter family; Region: EamA; pfam00892 391616003564 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616003565 Putative transposase; Region: Y2_Tnp; pfam04986 391616003566 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616003567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616003568 active site 391616003569 DNA binding site [nucleotide binding] 391616003570 Int/Topo IB signature motif; other site 391616003571 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616003572 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391616003573 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616003574 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 391616003575 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391616003576 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616003577 catalytic loop [active] 391616003578 iron binding site [ion binding]; other site 391616003579 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 391616003580 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 391616003581 active site 391616003582 catalytic residue [active] 391616003583 enoyl-CoA hydratase; Validated; Region: PRK08139 391616003584 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616003585 substrate binding site [chemical binding]; other site 391616003586 oxyanion hole (OAH) forming residues; other site 391616003587 trimer interface [polypeptide binding]; other site 391616003588 acyl-CoA synthetase; Validated; Region: PRK08162 391616003589 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391616003590 acyl-activating enzyme (AAE) consensus motif; other site 391616003591 putative active site [active] 391616003592 AMP binding site [chemical binding]; other site 391616003593 putative CoA binding site [chemical binding]; other site 391616003594 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391616003595 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616003596 Integrase core domain; Region: rve; pfam00665 391616003597 Integrase core domain; Region: rve_3; pfam13683 391616003598 Dehydratase family; Region: ILVD_EDD; cl00340 391616003599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616003601 putative substrate translocation pore; other site 391616003602 Integrase core domain; Region: rve; pfam00665 391616003603 Integrase core domain; Region: rve_3; cl15866 391616003604 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003605 MULE transposase domain; Region: MULE; pfam10551 391616003606 Integrase core domain; Region: rve; pfam00665 391616003607 Integrase core domain; Region: rve_3; pfam13683 391616003608 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 391616003609 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 391616003610 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616003611 catalytic loop [active] 391616003612 iron binding site [ion binding]; other site 391616003613 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391616003614 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391616003615 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 391616003616 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391616003617 active site 391616003618 PAS domain; Region: PAS_9; pfam13426 391616003619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391616003620 putative active site [active] 391616003621 heme pocket [chemical binding]; other site 391616003622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616003623 dimer interface [polypeptide binding]; other site 391616003624 phosphorylation site [posttranslational modification] 391616003625 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616003626 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003627 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003629 Transposase; Region: HTH_Tnp_1; pfam01527 391616003630 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616003631 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616003632 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391616003633 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 391616003634 putative active site [active] 391616003635 putative FMN binding site [chemical binding]; other site 391616003636 putative substrate binding site [chemical binding]; other site 391616003637 putative catalytic residue [active] 391616003638 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616003639 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 391616003640 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391616003641 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 391616003642 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 391616003643 putative NAD(P) binding site [chemical binding]; other site 391616003644 dimer interface [polypeptide binding]; other site 391616003645 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003646 MULE transposase domain; Region: MULE; pfam10551 391616003647 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616003648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 391616003649 dimer interface [polypeptide binding]; other site 391616003650 phosphorylation site [posttranslational modification] 391616003651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616003652 ATP binding site [chemical binding]; other site 391616003653 Mg2+ binding site [ion binding]; other site 391616003654 G-X-G motif; other site 391616003655 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616003656 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616003657 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616003658 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616003659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391616003660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616003661 active site 391616003662 phosphorylation site [posttranslational modification] 391616003663 intermolecular recognition site; other site 391616003664 dimerization interface [polypeptide binding]; other site 391616003665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616003666 DNA binding site [nucleotide binding] 391616003667 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 391616003668 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 391616003669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 391616003670 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003671 Transposase; Region: HTH_Tnp_1; pfam01527 391616003672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003673 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616003674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003675 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003676 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003677 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616003678 RNA polymerase sigma factor; Provisional; Region: PRK12546 391616003679 recombinase A; Provisional; Region: recA; PRK09354 391616003680 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391616003681 hexamer interface [polypeptide binding]; other site 391616003682 Walker A motif; other site 391616003683 ATP binding site [chemical binding]; other site 391616003684 Walker B motif; other site 391616003685 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391616003686 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 391616003687 motif 1; other site 391616003688 active site 391616003689 motif 2; other site 391616003690 motif 3; other site 391616003691 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391616003692 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003693 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003694 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003695 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003696 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 391616003697 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 391616003698 G1 box; other site 391616003699 putative GEF interaction site [polypeptide binding]; other site 391616003700 GTP/Mg2+ binding site [chemical binding]; other site 391616003701 Switch I region; other site 391616003702 G2 box; other site 391616003703 G3 box; other site 391616003704 Switch II region; other site 391616003705 G4 box; other site 391616003706 G5 box; other site 391616003707 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391616003708 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 391616003709 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 391616003710 Uncharacterized conserved protein [Function unknown]; Region: COG1284 391616003711 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 391616003712 isocitrate dehydrogenase; Validated; Region: PRK08299 391616003713 HD domain; Region: HD_3; pfam13023 391616003714 HD domain; Region: HD_3; pfam13023 391616003715 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 391616003716 Transcriptional regulator; Region: Rrf2; cl17282 391616003717 Rrf2 family protein; Region: rrf2_super; TIGR00738 391616003718 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616003719 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 391616003720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616003721 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616003722 catalytic residue [active] 391616003723 catalytic residue [active] 391616003724 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 391616003725 putative ABC transporter; Region: ycf24; CHL00085 391616003726 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 391616003727 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 391616003728 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 391616003729 Walker A/P-loop; other site 391616003730 ATP binding site [chemical binding]; other site 391616003731 Q-loop/lid; other site 391616003732 ABC transporter signature motif; other site 391616003733 Walker B; other site 391616003734 D-loop; other site 391616003735 H-loop/switch region; other site 391616003736 FeS assembly protein SufD; Region: sufD; TIGR01981 391616003737 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 391616003738 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391616003739 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391616003740 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616003741 catalytic residue [active] 391616003742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616003743 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616003744 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616003745 HTH-like domain; Region: HTH_21; pfam13276 391616003746 Integrase core domain; Region: rve; pfam00665 391616003747 Integrase core domain; Region: rve_3; pfam13683 391616003748 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616003749 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616003750 Integrase core domain; Region: rve; pfam00665 391616003751 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616003752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616003753 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616003754 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 391616003755 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616003756 active site 391616003757 Int/Topo IB signature motif; other site 391616003758 DNA binding site [nucleotide binding] 391616003759 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003760 Transposase; Region: HTH_Tnp_1; pfam01527 391616003761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003762 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616003763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003764 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003765 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003766 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616003767 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 391616003768 Protein of unknown function (DUF723); Region: DUF723; pfam05265 391616003769 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 391616003770 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391616003771 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616003772 catalytic residues [active] 391616003773 catalytic nucleophile [active] 391616003774 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616003775 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616003776 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616003777 Synaptic Site I dimer interface [polypeptide binding]; other site 391616003778 DNA binding site [nucleotide binding] 391616003779 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391616003780 DNA-binding interface [nucleotide binding]; DNA binding site 391616003781 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616003782 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616003783 binding surface 391616003784 TPR motif; other site 391616003785 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616003786 Transposase; Region: HTH_Tnp_1; pfam01527 391616003787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003788 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616003789 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616003790 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003791 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616003792 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616003793 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391616003794 classical (c) SDRs; Region: SDR_c; cd05233 391616003795 NAD(P) binding site [chemical binding]; other site 391616003796 active site 391616003797 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391616003798 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391616003799 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391616003800 non-specific DNA interactions [nucleotide binding]; other site 391616003801 DNA binding site [nucleotide binding] 391616003802 sequence specific DNA binding site [nucleotide binding]; other site 391616003803 putative cAMP binding site [chemical binding]; other site 391616003804 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 391616003805 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 391616003806 integrase; Provisional; Region: PRK09692 391616003807 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391616003808 active site 391616003809 Int/Topo IB signature motif; other site 391616003810 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616003811 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003812 MULE transposase domain; Region: MULE; pfam10551 391616003813 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616003814 non-specific DNA binding site [nucleotide binding]; other site 391616003815 salt bridge; other site 391616003816 sequence-specific DNA binding site [nucleotide binding]; other site 391616003817 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391616003818 putative FMN binding site [chemical binding]; other site 391616003819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616003820 ABC transporter signature motif; other site 391616003821 Walker B; other site 391616003822 D-loop; other site 391616003823 H-loop/switch region; other site 391616003824 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616003825 Integrase core domain; Region: rve; pfam00665 391616003826 Integrase core domain; Region: rve_3; pfam13683 391616003827 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003828 Homeodomain-like domain; Region: HTH_32; pfam13565 391616003829 Integrase core domain; Region: rve; pfam00665 391616003830 Integrase core domain; Region: rve_3; pfam13683 391616003831 Transposase; Region: HTH_Tnp_1; cl17663 391616003832 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003833 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003834 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003836 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391616003837 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391616003838 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616003839 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616003840 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616003841 Walker A/P-loop; other site 391616003842 ATP binding site [chemical binding]; other site 391616003843 Q-loop/lid; other site 391616003844 ABC transporter signature motif; other site 391616003845 Walker B; other site 391616003846 D-loop; other site 391616003847 H-loop/switch region; other site 391616003848 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616003849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616003850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616003851 TM-ABC transporter signature motif; other site 391616003852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616003853 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616003854 TM-ABC transporter signature motif; other site 391616003855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616003856 acetoin reductases; Region: 23BDH; TIGR02415 391616003857 NAD(P) binding site [chemical binding]; other site 391616003858 active site 391616003859 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 391616003860 putative ligand binding site [chemical binding]; other site 391616003861 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391616003862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616003863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616003864 sorbitol dehydrogenase; Provisional; Region: PRK07067 391616003865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616003866 NAD(P) binding site [chemical binding]; other site 391616003867 active site 391616003868 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616003869 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616003870 active site 391616003871 pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149 391616003872 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391616003873 tetramer interface [polypeptide binding]; other site 391616003874 TPP-binding site [chemical binding]; other site 391616003875 heterodimer interface [polypeptide binding]; other site 391616003876 phosphorylation loop region [posttranslational modification] 391616003877 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391616003878 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391616003879 alpha subunit interface [polypeptide binding]; other site 391616003880 TPP binding site [chemical binding]; other site 391616003881 heterodimer interface [polypeptide binding]; other site 391616003882 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616003883 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616003884 E3 interaction surface; other site 391616003885 lipoyl attachment site [posttranslational modification]; other site 391616003886 e3 binding domain; Region: E3_binding; pfam02817 391616003887 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616003888 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391616003889 tetramerization interface [polypeptide binding]; other site 391616003890 NAD(P) binding site [chemical binding]; other site 391616003891 catalytic residues [active] 391616003892 HTH-like domain; Region: HTH_21; pfam13276 391616003893 Integrase core domain; Region: rve; pfam00665 391616003894 Integrase core domain; Region: rve_3; pfam13683 391616003895 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616003896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616003897 Walker A motif; other site 391616003898 ATP binding site [chemical binding]; other site 391616003899 Walker B motif; other site 391616003900 arginine finger; other site 391616003901 Integrase core domain; Region: rve; pfam00665 391616003902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616003903 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003904 MULE transposase domain; Region: MULE; pfam10551 391616003905 H-NS histone family; Region: Histone_HNS; pfam00816 391616003906 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616003907 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391616003908 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391616003909 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391616003910 DNA binding residues [nucleotide binding] 391616003911 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391616003912 dimer interface [polypeptide binding]; other site 391616003913 putative metal binding site [ion binding]; other site 391616003914 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 391616003915 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 391616003916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616003917 dimer interface [polypeptide binding]; other site 391616003918 phosphorylation site [posttranslational modification] 391616003919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616003920 Mg2+ binding site [ion binding]; other site 391616003921 G-X-G motif; other site 391616003922 Response regulator receiver domain; Region: Response_reg; pfam00072 391616003923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616003924 active site 391616003925 phosphorylation site [posttranslational modification] 391616003926 intermolecular recognition site; other site 391616003927 dimerization interface [polypeptide binding]; other site 391616003928 Glucokinase; Region: Glucokinase; pfam02685 391616003929 glucokinase, proteobacterial type; Region: glk; TIGR00749 391616003930 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391616003931 beta-galactosidase; Region: BGL; TIGR03356 391616003932 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 391616003933 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 391616003934 ligand binding site [chemical binding]; other site 391616003935 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616003936 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616003937 Integrase core domain; Region: rve; pfam00665 391616003938 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616003939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616003940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616003941 putative PBP binding loops; other site 391616003942 dimer interface [polypeptide binding]; other site 391616003943 ABC-ATPase subunit interface; other site 391616003944 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003945 Integrase core domain; Region: rve; pfam00665 391616003946 Integrase core domain; Region: rve_3; pfam13683 391616003947 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 391616003948 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 391616003949 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616003950 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616003951 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616003952 Integrase core domain; Region: rve; pfam00665 391616003953 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616003954 MULE transposase domain; Region: MULE; pfam10551 391616003955 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003956 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003957 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003959 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003960 Homeodomain-like domain; Region: HTH_32; pfam13565 391616003961 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003962 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003963 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003964 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 391616003965 Protein of unknown function (DUF330); Region: DUF330; cl01135 391616003966 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 391616003967 mce related protein; Region: MCE; pfam02470 391616003968 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391616003969 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 391616003970 Walker A/P-loop; other site 391616003971 ATP binding site [chemical binding]; other site 391616003972 Q-loop/lid; other site 391616003973 ABC transporter signature motif; other site 391616003974 Walker B; other site 391616003975 D-loop; other site 391616003976 H-loop/switch region; other site 391616003977 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 391616003978 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391616003979 Permease; Region: Permease; pfam02405 391616003980 Predicted deacylase [General function prediction only]; Region: COG3608 391616003981 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 391616003982 putative active site [active] 391616003983 Zn binding site [ion binding]; other site 391616003984 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 391616003985 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 391616003986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616003987 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 391616003988 Serine hydrolase (FSH1); Region: FSH1; pfam03959 391616003989 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 391616003990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616003991 dimerization interface [polypeptide binding]; other site 391616003992 Winged helix-turn helix; Region: HTH_29; pfam13551 391616003993 Winged helix-turn helix; Region: HTH_33; pfam13592 391616003994 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616003995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616003996 DNA Polymerase Y-family; Region: PolY_like; cd03468 391616003997 active site 391616003998 Uncharacterized conserved protein [Function unknown]; Region: COG4544 391616003999 hypothetical protein; Provisional; Region: PRK07877 391616004000 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 391616004001 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616004002 Sel1-like repeats; Region: SEL1; smart00671 391616004003 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 391616004004 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 391616004005 potential catalytic triad [active] 391616004006 conserved cys residue [active] 391616004007 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616004008 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616004009 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616004010 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616004011 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391616004012 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616004013 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616004014 active site 391616004015 catalytic tetrad [active] 391616004016 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 391616004017 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 391616004018 active site 391616004019 dimer interface [polypeptide binding]; other site 391616004020 non-prolyl cis peptide bond; other site 391616004021 insertion regions; other site 391616004022 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391616004023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616004024 DNA-binding site [nucleotide binding]; DNA binding site 391616004025 UTRA domain; Region: UTRA; pfam07702 391616004026 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616004027 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616004028 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616004029 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391616004030 Rhomboid family; Region: Rhomboid; pfam01694 391616004031 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004032 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004033 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616004034 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616004035 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616004036 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616004037 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616004038 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391616004039 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 391616004040 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 391616004041 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 391616004042 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004043 MULE transposase domain; Region: MULE; pfam10551 391616004044 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004045 MULE transposase domain; Region: MULE; pfam10551 391616004046 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004047 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004048 Integrase core domain; Region: rve; pfam00665 391616004049 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 391616004050 Integrase core domain; Region: rve; pfam00665 391616004051 Integrase core domain; Region: rve_3; pfam13683 391616004052 photolyase PhrII; Region: phr2; TIGR00591 391616004053 DNA photolyase; Region: DNA_photolyase; pfam00875 391616004054 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 391616004055 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616004056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004057 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004058 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004059 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616004060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004061 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004063 Transposase; Region: HTH_Tnp_1; pfam01527 391616004064 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004065 Putative transposase; Region: Y2_Tnp; pfam04986 391616004066 Integrase core domain; Region: rve; pfam00665 391616004067 Integrase core domain; Region: rve_3; pfam13683 391616004068 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616004069 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616004070 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616004071 choline dehydrogenase; Validated; Region: PRK02106 391616004072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616004073 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616004074 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616004075 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616004076 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616004077 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616004078 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616004079 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616004080 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616004081 short chain dehydrogenase; Provisional; Region: PRK06198 391616004082 classical (c) SDRs; Region: SDR_c; cd05233 391616004083 NAD(P) binding site [chemical binding]; other site 391616004084 active site 391616004085 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391616004086 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391616004087 putative ligand binding site [chemical binding]; other site 391616004088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391616004089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004090 Walker A/P-loop; other site 391616004091 ATP binding site [chemical binding]; other site 391616004092 Q-loop/lid; other site 391616004093 ABC transporter signature motif; other site 391616004094 Walker B; other site 391616004095 D-loop; other site 391616004096 H-loop/switch region; other site 391616004097 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616004098 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616004099 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616004100 TM-ABC transporter signature motif; other site 391616004101 Integrase core domain; Region: rve; pfam00665 391616004102 Integrase core domain; Region: rve_3; pfam13683 391616004103 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004104 Putative transposase; Region: Y2_Tnp; pfam04986 391616004105 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004106 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004107 active site 391616004108 DNA binding site [nucleotide binding] 391616004109 Int/Topo IB signature motif; other site 391616004110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616004111 putative substrate translocation pore; other site 391616004112 agmatinase; Region: agmatinase; TIGR01230 391616004113 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 391616004114 oligomer interface [polypeptide binding]; other site 391616004115 active site 391616004116 Mn binding site [ion binding]; other site 391616004117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004118 active site 391616004119 DNA binding site [nucleotide binding] 391616004120 Int/Topo IB signature motif; other site 391616004121 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004122 Integrase core domain; Region: rve; pfam00665 391616004123 Integrase core domain; Region: rve_3; pfam13683 391616004124 putative transposase OrfB; Reviewed; Region: PHA02517 391616004125 HTH-like domain; Region: HTH_21; pfam13276 391616004126 Integrase core domain; Region: rve; pfam00665 391616004127 Integrase core domain; Region: rve_3; pfam13683 391616004128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004129 Transposase; Region: HTH_Tnp_1; pfam01527 391616004130 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391616004131 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391616004132 catalytic residues [active] 391616004133 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616004134 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616004135 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616004136 Integrase core domain; Region: rve; pfam00665 391616004137 Integrase core domain; Region: rve_3; pfam13683 391616004138 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004139 Homeodomain-like domain; Region: HTH_32; pfam13565 391616004140 Integrase core domain; Region: rve; pfam00665 391616004141 Integrase core domain; Region: rve_3; pfam13683 391616004142 HTH-like domain; Region: HTH_21; pfam13276 391616004143 Integrase core domain; Region: rve; pfam00665 391616004144 Integrase core domain; Region: rve_3; pfam13683 391616004145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616004146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616004147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004148 Walker A/P-loop; other site 391616004149 ATP binding site [chemical binding]; other site 391616004150 Q-loop/lid; other site 391616004151 ABC transporter signature motif; other site 391616004152 Walker B; other site 391616004153 D-loop; other site 391616004154 H-loop/switch region; other site 391616004155 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 391616004156 substrate binding site [chemical binding]; other site 391616004157 multimerization interface [polypeptide binding]; other site 391616004158 ATP binding site [chemical binding]; other site 391616004159 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391616004160 thiamine phosphate binding site [chemical binding]; other site 391616004161 active site 391616004162 pyrophosphate binding site [ion binding]; other site 391616004163 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391616004164 dimer interface [polypeptide binding]; other site 391616004165 substrate binding site [chemical binding]; other site 391616004166 ATP binding site [chemical binding]; other site 391616004167 NMT1/THI5 like; Region: NMT1; pfam09084 391616004168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391616004169 Putative transcription activator [Transcription]; Region: TenA; COG0819 391616004170 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616004171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004172 Walker A/P-loop; other site 391616004173 ATP binding site [chemical binding]; other site 391616004174 Q-loop/lid; other site 391616004175 ABC transporter signature motif; other site 391616004176 Walker B; other site 391616004177 D-loop; other site 391616004178 H-loop/switch region; other site 391616004179 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616004180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004181 dimer interface [polypeptide binding]; other site 391616004182 conserved gate region; other site 391616004183 putative PBP binding loops; other site 391616004184 ABC-ATPase subunit interface; other site 391616004185 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 391616004186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391616004187 Integrase core domain; Region: rve; pfam00665 391616004188 Integrase core domain; Region: rve_3; pfam13683 391616004189 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 391616004190 polymerase nucleotide-binding site; other site 391616004191 DNA-binding residues [nucleotide binding]; DNA binding site 391616004192 nucleotide binding site [chemical binding]; other site 391616004193 primase nucleotide-binding site [nucleotide binding]; other site 391616004194 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 391616004195 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391616004196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616004197 putative ligand binding site [chemical binding]; other site 391616004198 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616004199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616004200 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616004201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004202 MULE transposase domain; Region: MULE; pfam10551 391616004203 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004204 active site 391616004205 DNA binding site [nucleotide binding] 391616004206 Int/Topo IB signature motif; other site 391616004207 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391616004208 Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772 391616004209 N- and C-terminal domain interface [polypeptide binding]; other site 391616004210 putative active site [active] 391616004211 putative MgATP binding site [chemical binding]; other site 391616004212 putative catalytic site [active] 391616004213 metal binding site [ion binding]; metal-binding site 391616004214 putative carbohydrate binding site [chemical binding]; other site 391616004215 Domain of unknown function (DUF718); Region: DUF718; pfam05336 391616004216 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616004217 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616004218 TM-ABC transporter signature motif; other site 391616004219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616004220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616004221 TM-ABC transporter signature motif; other site 391616004222 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004223 Homeodomain-like domain; Region: HTH_32; pfam13565 391616004224 Winged helix-turn helix; Region: HTH_33; pfam13592 391616004225 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616004226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616004227 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004228 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004229 Integrase core domain; Region: rve; pfam00665 391616004230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616004231 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616004232 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 391616004233 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 391616004234 ligand binding site [chemical binding]; other site 391616004235 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391616004236 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391616004237 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391616004238 short chain dehydrogenase; Validated; Region: PRK08324 391616004239 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 391616004240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616004241 NAD(P) binding site [chemical binding]; other site 391616004242 active site 391616004243 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952 391616004244 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 391616004245 AAA domain; Region: AAA_25; pfam13481 391616004246 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391616004247 ATP binding site [chemical binding]; other site 391616004248 Walker B motif; other site 391616004249 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004250 MULE transposase domain; Region: MULE; pfam10551 391616004251 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391616004252 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 391616004253 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391616004254 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391616004255 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391616004256 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 391616004257 ligand binding site [chemical binding]; other site 391616004258 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616004259 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616004260 TM-ABC transporter signature motif; other site 391616004261 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616004262 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616004263 TM-ABC transporter signature motif; other site 391616004264 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391616004265 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616004266 Walker A/P-loop; other site 391616004267 ATP binding site [chemical binding]; other site 391616004268 Q-loop/lid; other site 391616004269 ABC transporter signature motif; other site 391616004270 Walker B; other site 391616004271 D-loop; other site 391616004272 H-loop/switch region; other site 391616004273 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391616004274 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616004275 Walker A/P-loop; other site 391616004276 ATP binding site [chemical binding]; other site 391616004277 Q-loop/lid; other site 391616004278 ABC transporter signature motif; other site 391616004279 Walker B; other site 391616004280 D-loop; other site 391616004281 H-loop/switch region; other site 391616004282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616004283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616004284 Transposase; Region: HTH_Tnp_1; pfam01527 391616004285 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616004286 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616004287 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616004288 dimerization interface [polypeptide binding]; other site 391616004289 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 391616004290 substrate binding pocket [chemical binding]; other site 391616004291 active site 391616004292 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 391616004293 Moco binding site; other site 391616004294 metal coordination site [ion binding]; other site 391616004295 dimerization interface [polypeptide binding]; other site 391616004296 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004297 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004298 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004299 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004300 active site 391616004301 DNA binding site [nucleotide binding] 391616004302 Int/Topo IB signature motif; other site 391616004303 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004304 Putative transposase; Region: Y2_Tnp; pfam04986 391616004305 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616004306 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616004307 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616004308 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391616004309 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 391616004310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004311 Transposase; Region: HTH_Tnp_1; pfam01527 391616004312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004313 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004315 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004316 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004317 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616004318 Predicted permeases [General function prediction only]; Region: COG0679 391616004319 heat shock protein 90; Provisional; Region: PRK05218 391616004320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616004321 ATP binding site [chemical binding]; other site 391616004322 Mg2+ binding site [ion binding]; other site 391616004323 G-X-G motif; other site 391616004324 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004325 active site 391616004326 DNA binding site [nucleotide binding] 391616004327 Int/Topo IB signature motif; other site 391616004328 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004329 Integrase core domain; Region: rve; pfam00665 391616004330 Integrase core domain; Region: rve_3; pfam13683 391616004331 Integrase core domain; Region: rve; pfam00665 391616004332 Integrase core domain; Region: rve_3; pfam13683 391616004333 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391616004334 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391616004335 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004336 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004337 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004338 Winged helix-turn helix; Region: HTH_33; pfam13592 391616004339 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616004340 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616004341 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616004342 Sel1-like repeats; Region: SEL1; smart00671 391616004343 Sel1-like repeats; Region: SEL1; smart00671 391616004344 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004345 Winged helix-turn helix; Region: HTH_33; pfam13592 391616004346 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616004347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616004348 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004349 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 391616004350 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 391616004351 Integrase core domain; Region: rve; pfam00665 391616004352 Integrase core domain; Region: rve_3; pfam13683 391616004353 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391616004354 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391616004355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391616004356 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391616004357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616004358 active site 391616004359 phosphorylation site [posttranslational modification] 391616004360 intermolecular recognition site; other site 391616004361 dimerization interface [polypeptide binding]; other site 391616004362 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616004363 DNA binding site [nucleotide binding] 391616004364 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 391616004365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616004366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 391616004367 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616004368 dimer interface [polypeptide binding]; other site 391616004369 phosphorylation site [posttranslational modification] 391616004370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616004371 ATP binding site [chemical binding]; other site 391616004372 Mg2+ binding site [ion binding]; other site 391616004373 G-X-G motif; other site 391616004374 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 391616004375 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391616004376 Integrase core domain; Region: rve; pfam00665 391616004377 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004378 Winged helix-turn helix; Region: HTH_33; pfam13592 391616004379 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616004380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616004381 Helix-turn-helix domain; Region: HTH_28; pfam13518 391616004382 Integrase core domain; Region: rve; pfam00665 391616004383 Integrase core domain; Region: rve_3; pfam13683 391616004384 allantoate amidohydrolase; Reviewed; Region: PRK12893 391616004385 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391616004386 active site 391616004387 metal binding site [ion binding]; metal-binding site 391616004388 dimer interface [polypeptide binding]; other site 391616004389 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 391616004390 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 391616004391 active site 391616004392 catalytic site [active] 391616004393 substrate binding site [chemical binding]; other site 391616004394 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 391616004395 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391616004396 NADP binding site [chemical binding]; other site 391616004397 dimer interface [polypeptide binding]; other site 391616004398 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391616004399 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 391616004400 homodimer interface [polypeptide binding]; other site 391616004401 substrate-cofactor binding pocket; other site 391616004402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616004403 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616004404 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616004405 Walker A/P-loop; other site 391616004406 ATP binding site [chemical binding]; other site 391616004407 Q-loop/lid; other site 391616004408 ABC transporter signature motif; other site 391616004409 Walker B; other site 391616004410 D-loop; other site 391616004411 H-loop/switch region; other site 391616004412 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616004413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004414 dimer interface [polypeptide binding]; other site 391616004415 conserved gate region; other site 391616004416 putative PBP binding loops; other site 391616004417 ABC-ATPase subunit interface; other site 391616004418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004419 dimer interface [polypeptide binding]; other site 391616004420 conserved gate region; other site 391616004421 putative PBP binding loops; other site 391616004422 ABC-ATPase subunit interface; other site 391616004423 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616004424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616004425 substrate binding pocket [chemical binding]; other site 391616004426 membrane-bound complex binding site; other site 391616004427 hinge residues; other site 391616004428 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391616004429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616004430 DNA-binding site [nucleotide binding]; DNA binding site 391616004431 FCD domain; Region: FCD; pfam07729 391616004432 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004433 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004434 active site 391616004435 DNA binding site [nucleotide binding] 391616004436 Int/Topo IB signature motif; other site 391616004437 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004438 Putative transposase; Region: Y2_Tnp; pfam04986 391616004439 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 391616004440 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 391616004441 Chromate transporter; Region: Chromate_transp; pfam02417 391616004442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616004443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616004444 active site 391616004445 catalytic tetrad [active] 391616004446 Integrase core domain; Region: rve; pfam00665 391616004447 Integrase core domain; Region: rve_3; pfam13683 391616004448 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004449 Homeodomain-like domain; Region: HTH_32; pfam13565 391616004450 Integrase core domain; Region: rve; pfam00665 391616004451 Integrase core domain; Region: rve_3; pfam13683 391616004452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616004453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616004454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 391616004455 putative effector binding pocket; other site 391616004456 putative dimerization interface [polypeptide binding]; other site 391616004457 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391616004458 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391616004459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 391616004460 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391616004461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391616004462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616004463 DNA binding site [nucleotide binding] 391616004464 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391616004465 putative ligand binding site [chemical binding]; other site 391616004466 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616004467 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391616004468 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391616004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004470 dimer interface [polypeptide binding]; other site 391616004471 conserved gate region; other site 391616004472 putative PBP binding loops; other site 391616004473 ABC-ATPase subunit interface; other site 391616004474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004475 dimer interface [polypeptide binding]; other site 391616004476 conserved gate region; other site 391616004477 putative PBP binding loops; other site 391616004478 ABC-ATPase subunit interface; other site 391616004479 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616004480 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616004481 substrate binding pocket [chemical binding]; other site 391616004482 membrane-bound complex binding site; other site 391616004483 hinge residues; other site 391616004484 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616004485 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616004486 Walker A/P-loop; other site 391616004487 ATP binding site [chemical binding]; other site 391616004488 Q-loop/lid; other site 391616004489 ABC transporter signature motif; other site 391616004490 Walker B; other site 391616004491 D-loop; other site 391616004492 H-loop/switch region; other site 391616004493 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391616004494 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 391616004495 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004496 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004497 Integrase core domain; Region: rve; pfam00665 391616004498 H-NS histone family; Region: Histone_HNS; pfam00816 391616004499 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616004500 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004501 Putative transposase; Region: Y2_Tnp; pfam04986 391616004502 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004503 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004504 active site 391616004505 DNA binding site [nucleotide binding] 391616004506 Int/Topo IB signature motif; other site 391616004507 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 391616004508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616004509 S-adenosylmethionine binding site [chemical binding]; other site 391616004510 FOG: CBS domain [General function prediction only]; Region: COG0517 391616004511 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391616004512 RNA polymerase Rpb4; Region: RNA_pol_Rpb4; cl00638 391616004513 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004514 Winged helix-turn helix; Region: HTH_33; pfam13592 391616004515 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616004516 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616004517 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391616004518 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 391616004519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616004520 Phospholipid methyltransferase; Region: PEMT; cl17370 391616004521 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391616004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616004523 active site 391616004524 phosphorylation site [posttranslational modification] 391616004525 intermolecular recognition site; other site 391616004526 dimerization interface [polypeptide binding]; other site 391616004527 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391616004528 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391616004529 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004530 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004531 Integrase core domain; Region: rve; pfam00665 391616004532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616004533 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616004534 YaeQ protein; Region: YaeQ; pfam07152 391616004535 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 391616004536 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 391616004537 active site 391616004538 catalytic site [active] 391616004539 substrate binding site [chemical binding]; other site 391616004540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004541 active site 391616004542 DNA binding site [nucleotide binding] 391616004543 Int/Topo IB signature motif; other site 391616004544 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616004545 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004546 MULE transposase domain; Region: MULE; pfam10551 391616004547 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391616004548 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 391616004549 catalytic residues [active] 391616004550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004551 Transposase; Region: HTH_Tnp_1; pfam01527 391616004552 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004553 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004555 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004556 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004557 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616004558 Transposase; Region: HTH_Tnp_1; cl17663 391616004559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004560 putative transposase OrfB; Reviewed; Region: PHA02517 391616004561 HTH-like domain; Region: HTH_21; pfam13276 391616004562 Integrase core domain; Region: rve; pfam00665 391616004563 Integrase core domain; Region: rve_3; cl15866 391616004564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391616004565 putative acyl-acceptor binding pocket; other site 391616004566 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391616004567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616004568 DNA binding site [nucleotide binding] 391616004569 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391616004570 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391616004571 putative ligand binding site [chemical binding]; other site 391616004572 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004573 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004574 active site 391616004575 DNA binding site [nucleotide binding] 391616004576 Int/Topo IB signature motif; other site 391616004577 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004578 Putative transposase; Region: Y2_Tnp; pfam04986 391616004579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616004580 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 391616004581 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391616004582 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391616004583 ring oligomerisation interface [polypeptide binding]; other site 391616004584 ATP/Mg binding site [chemical binding]; other site 391616004585 stacking interactions; other site 391616004586 hinge regions; other site 391616004587 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391616004588 oligomerisation interface [polypeptide binding]; other site 391616004589 mobile loop; other site 391616004590 roof hairpin; other site 391616004591 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616004592 Putative transposase; Region: Y2_Tnp; pfam04986 391616004593 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616004594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004595 active site 391616004596 DNA binding site [nucleotide binding] 391616004597 Int/Topo IB signature motif; other site 391616004598 cyanate hydratase; Validated; Region: PRK02866 391616004599 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 391616004600 oligomer interface [polypeptide binding]; other site 391616004601 active site 391616004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 391616004603 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616004604 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616004605 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391616004606 Walker A/P-loop; other site 391616004607 ATP binding site [chemical binding]; other site 391616004608 Q-loop/lid; other site 391616004609 ABC transporter signature motif; other site 391616004610 Walker B; other site 391616004611 D-loop; other site 391616004612 H-loop/switch region; other site 391616004613 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616004614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004615 dimer interface [polypeptide binding]; other site 391616004616 conserved gate region; other site 391616004617 putative PBP binding loops; other site 391616004618 ABC-ATPase subunit interface; other site 391616004619 NMT1-like family; Region: NMT1_2; pfam13379 391616004620 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391616004621 PAS domain S-box; Region: sensory_box; TIGR00229 391616004622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391616004623 putative active site [active] 391616004624 heme pocket [chemical binding]; other site 391616004625 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616004626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616004627 Walker A motif; other site 391616004628 ATP binding site [chemical binding]; other site 391616004629 Walker B motif; other site 391616004630 arginine finger; other site 391616004631 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391616004632 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391616004633 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391616004634 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391616004635 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391616004636 putative hydrophobic ligand binding site [chemical binding]; other site 391616004637 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391616004638 Ligand binding site; other site 391616004639 metal-binding site 391616004640 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391616004641 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391616004642 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391616004643 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391616004644 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 391616004645 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616004646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616004647 Walker A motif; other site 391616004648 ATP binding site [chemical binding]; other site 391616004649 Walker B motif; other site 391616004650 arginine finger; other site 391616004651 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 391616004652 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 391616004653 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616004654 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391616004655 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616004656 catalytic loop [active] 391616004657 iron binding site [ion binding]; other site 391616004658 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391616004659 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391616004660 FAD binding domain; Region: FAD_binding_4; pfam01565 391616004661 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391616004662 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 391616004663 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391616004664 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391616004665 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 391616004666 LytTr DNA-binding domain; Region: LytTR; smart00850 391616004667 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004668 Transposase; Region: HTH_Tnp_1; cl17663 391616004669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616004670 Integrase core domain; Region: rve; pfam00665 391616004671 Integrase core domain; Region: rve_3; pfam13683 391616004672 agmatinase; Region: agmatinase; TIGR01230 391616004673 Agmatinase and related proteins; Region: Agmatinase_like_1; cd11589 391616004674 oligomer interface [polypeptide binding]; other site 391616004675 active site 391616004676 Mn binding site [ion binding]; other site 391616004677 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004678 active site 391616004679 DNA binding site [nucleotide binding] 391616004680 Int/Topo IB signature motif; other site 391616004681 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391616004682 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391616004683 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391616004684 catalytic residues [active] 391616004685 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004686 MULE transposase domain; Region: MULE; pfam10551 391616004687 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391616004688 Integrase core domain; Region: rve; pfam00665 391616004689 Integrase core domain; Region: rve_3; pfam13683 391616004690 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616004691 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616004692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004693 Walker A/P-loop; other site 391616004694 ATP binding site [chemical binding]; other site 391616004695 Q-loop/lid; other site 391616004696 ABC transporter signature motif; other site 391616004697 Walker B; other site 391616004698 D-loop; other site 391616004699 H-loop/switch region; other site 391616004700 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004701 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004702 Integrase core domain; Region: rve; pfam00665 391616004703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616004704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616004705 active site 391616004706 catalytic tetrad [active] 391616004707 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391616004708 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 391616004709 cofactor binding site; other site 391616004710 DNA binding site [nucleotide binding] 391616004711 substrate interaction site [chemical binding]; other site 391616004712 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 391616004713 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391616004714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004715 Transposase; Region: HTH_Tnp_1; pfam01527 391616004716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004717 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004718 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004719 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004720 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004721 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616004722 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004723 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004724 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 391616004725 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 391616004726 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616004727 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 391616004728 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616004729 DNA binding residues [nucleotide binding] 391616004730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616004731 ATP binding site [chemical binding]; other site 391616004732 Mg2+ binding site [ion binding]; other site 391616004733 G-X-G motif; other site 391616004734 Z1 domain; Region: Z1; pfam10593 391616004735 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 391616004736 AIPR protein; Region: AIPR; pfam10592 391616004737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4694 391616004738 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004739 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004740 Integrase core domain; Region: rve; pfam00665 391616004741 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616004742 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 391616004743 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 391616004744 active site 391616004745 metal binding site [ion binding]; metal-binding site 391616004746 DNA binding site [nucleotide binding] 391616004747 P-loop containing region of AAA domain; Region: AAA_29; cl17516 391616004748 AAA domain; Region: AAA_23; pfam13476 391616004749 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004750 active site 391616004751 DNA binding site [nucleotide binding] 391616004752 Int/Topo IB signature motif; other site 391616004753 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391616004754 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391616004755 putative dimer interface [polypeptide binding]; other site 391616004756 N-terminal domain interface [polypeptide binding]; other site 391616004757 putative substrate binding pocket (H-site) [chemical binding]; other site 391616004758 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 391616004759 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 391616004760 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 391616004761 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391616004762 active site 391616004763 FMN binding site [chemical binding]; other site 391616004764 substrate binding site [chemical binding]; other site 391616004765 3Fe-4S cluster binding site [ion binding]; other site 391616004766 DoxX-like family; Region: DoxX_2; pfam13564 391616004767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616004768 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616004769 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391616004770 dimerization interface [polypeptide binding]; other site 391616004771 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616004772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616004773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004774 Walker A/P-loop; other site 391616004775 ATP binding site [chemical binding]; other site 391616004776 Q-loop/lid; other site 391616004777 ABC transporter signature motif; other site 391616004778 Walker B; other site 391616004779 D-loop; other site 391616004780 H-loop/switch region; other site 391616004781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616004782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616004783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616004784 Integrase core domain; Region: rve; pfam00665 391616004785 Integrase core domain; Region: rve_3; pfam13683 391616004786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004787 Transposase; Region: HTH_Tnp_1; cl17663 391616004788 chromosomal replication initiation protein; Provisional; Region: PRK12422 391616004789 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616004790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616004791 DNA binding site [nucleotide binding] 391616004792 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616004793 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616004794 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616004795 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391616004796 DctM-like transporters; Region: DctM; pfam06808 391616004797 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616004798 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391616004799 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391616004800 tetramer interface [polypeptide binding]; other site 391616004801 TPP-binding site [chemical binding]; other site 391616004802 heterodimer interface [polypeptide binding]; other site 391616004803 phosphorylation loop region [posttranslational modification] 391616004804 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391616004805 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391616004806 alpha subunit interface [polypeptide binding]; other site 391616004807 TPP binding site [chemical binding]; other site 391616004808 heterodimer interface [polypeptide binding]; other site 391616004809 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616004810 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616004811 E3 interaction surface; other site 391616004812 lipoyl attachment site [posttranslational modification]; other site 391616004813 e3 binding domain; Region: E3_binding; pfam02817 391616004814 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616004815 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391616004816 tetramerization interface [polypeptide binding]; other site 391616004817 NAD(P) binding site [chemical binding]; other site 391616004818 catalytic residues [active] 391616004819 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391616004820 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391616004821 catalytic residues [active] 391616004822 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616004823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616004824 dimer interface [polypeptide binding]; other site 391616004825 conserved gate region; other site 391616004826 putative PBP binding loops; other site 391616004827 ABC-ATPase subunit interface; other site 391616004828 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 391616004829 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616004830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616004831 Walker A/P-loop; other site 391616004832 ATP binding site [chemical binding]; other site 391616004833 Q-loop/lid; other site 391616004834 ABC transporter signature motif; other site 391616004835 Walker B; other site 391616004836 D-loop; other site 391616004837 H-loop/switch region; other site 391616004838 Putative transcription activator [Transcription]; Region: TenA; COG0819 391616004839 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391616004840 NMT1/THI5 like; Region: NMT1; pfam09084 391616004841 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391616004842 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 391616004843 ATP binding site [chemical binding]; other site 391616004844 substrate interface [chemical binding]; other site 391616004845 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391616004846 active site 391616004847 thiamine phosphate binding site [chemical binding]; other site 391616004848 pyrophosphate binding site [ion binding]; other site 391616004849 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391616004850 ThiS interaction site; other site 391616004851 putative active site [active] 391616004852 tetramer interface [polypeptide binding]; other site 391616004853 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391616004854 thiS-thiF/thiG interaction site; other site 391616004855 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616004856 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391616004857 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391616004858 dimer interface [polypeptide binding]; other site 391616004859 substrate binding site [chemical binding]; other site 391616004860 ATP binding site [chemical binding]; other site 391616004861 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391616004862 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 391616004863 catalytic residues [active] 391616004864 YaeQ protein; Region: YaeQ; pfam07152 391616004865 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 391616004866 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 391616004867 active site 391616004868 catalytic site [active] 391616004869 substrate binding site [chemical binding]; other site 391616004870 Winged helix-turn helix; Region: HTH_29; pfam13551 391616004871 Integrase core domain; Region: rve; pfam00665 391616004872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004873 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616004874 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616004875 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616004876 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616004877 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616004878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004879 Transposase; Region: HTH_Tnp_1; pfam01527 391616004880 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616004881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616004882 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616004883 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616004884 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 391616004885 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 391616004886 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391616004887 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 391616004888 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391616004889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391616004890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616004891 GTPase CgtA; Reviewed; Region: obgE; PRK12299 391616004892 GTP1/OBG; Region: GTP1_OBG; pfam01018 391616004893 Obg GTPase; Region: Obg; cd01898 391616004894 G1 box; other site 391616004895 GTP/Mg2+ binding site [chemical binding]; other site 391616004896 Switch I region; other site 391616004897 G2 box; other site 391616004898 G3 box; other site 391616004899 Switch II region; other site 391616004900 G4 box; other site 391616004901 G5 box; other site 391616004902 gamma-glutamyl kinase; Provisional; Region: PRK05429 391616004903 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391616004904 nucleotide binding site [chemical binding]; other site 391616004905 homotetrameric interface [polypeptide binding]; other site 391616004906 putative phosphate binding site [ion binding]; other site 391616004907 putative allosteric binding site; other site 391616004908 PUA domain; Region: PUA; pfam01472 391616004909 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391616004910 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391616004911 putative catalytic cysteine [active] 391616004912 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 391616004913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391616004914 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391616004915 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391616004916 putative acyl-acceptor binding pocket; other site 391616004917 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391616004918 thiamine phosphate binding site [chemical binding]; other site 391616004919 active site 391616004920 pyrophosphate binding site [ion binding]; other site 391616004921 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 391616004922 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 391616004923 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 391616004924 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 391616004925 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 391616004926 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 391616004927 active site 391616004928 Zn binding site [ion binding]; other site 391616004929 enoyl-CoA hydratase; Validated; Region: PRK08139 391616004930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616004931 substrate binding site [chemical binding]; other site 391616004932 oxyanion hole (OAH) forming residues; other site 391616004933 trimer interface [polypeptide binding]; other site 391616004934 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391616004935 CoenzymeA binding site [chemical binding]; other site 391616004936 subunit interaction site [polypeptide binding]; other site 391616004937 PHB binding site; other site 391616004938 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391616004939 23S rRNA interface [nucleotide binding]; other site 391616004940 L3 interface [polypeptide binding]; other site 391616004941 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 391616004942 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616004943 MULE transposase domain; Region: MULE; pfam10551 391616004944 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616004945 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616004946 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616004947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616004948 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616004949 active site 391616004950 catalytic residues [active] 391616004951 DNA binding site [nucleotide binding] 391616004952 Int/Topo IB signature motif; other site 391616004953 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004954 Integrase core domain; Region: rve; pfam00665 391616004955 Integrase core domain; Region: rve; pfam00665 391616004956 Integrase core domain; Region: rve_3; pfam13683 391616004957 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391616004958 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 391616004959 cofactor binding site; other site 391616004960 DNA binding site [nucleotide binding] 391616004961 substrate interaction site [chemical binding]; other site 391616004962 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616004963 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616004964 Integrase core domain; Region: rve; pfam00665 391616004965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616004966 Transposase; Region: HTH_Tnp_1; pfam01527 391616004967 HTH-like domain; Region: HTH_21; pfam13276 391616004968 Integrase core domain; Region: rve; pfam00665 391616004969 Integrase core domain; Region: rve_3; pfam13683 391616004970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616004971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616004972 WHG domain; Region: WHG; pfam13305 391616004973 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391616004974 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391616004975 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391616004976 Homoserine O-succinyltransferase; Region: HTS; pfam04204 391616004977 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 391616004978 proposed active site lysine [active] 391616004979 conserved cys residue [active] 391616004980 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 391616004981 EamA-like transporter family; Region: EamA; pfam00892 391616004982 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616004983 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 391616004984 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 391616004985 putative active site [active] 391616004986 GMP synthase; Reviewed; Region: guaA; PRK00074 391616004987 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391616004988 AMP/PPi binding site [chemical binding]; other site 391616004989 candidate oxyanion hole; other site 391616004990 catalytic triad [active] 391616004991 potential glutamine specificity residues [chemical binding]; other site 391616004992 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391616004993 ATP Binding subdomain [chemical binding]; other site 391616004994 Ligand Binding sites [chemical binding]; other site 391616004995 Dimerization subdomain; other site 391616004996 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 391616004997 lipoyl synthase; Provisional; Region: PRK05481 391616004998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616004999 FeS/SAM binding site; other site 391616005000 Cytochrome c; Region: Cytochrom_C; pfam00034 391616005001 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 391616005002 Cytochrome c; Region: Cytochrom_C; pfam00034 391616005003 Cytochrome C' Region: Cytochrom_C_2; pfam01322 391616005004 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 391616005005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616005006 active site 391616005007 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 391616005008 putative coenzyme Q binding site [chemical binding]; other site 391616005009 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391616005010 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616005011 MULE transposase domain; Region: MULE; pfam10551 391616005012 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 391616005013 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 391616005014 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 391616005015 tetramer interfaces [polypeptide binding]; other site 391616005016 binuclear metal-binding site [ion binding]; other site 391616005017 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 391616005018 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391616005019 substrate binding site; other site 391616005020 dimer interface; other site 391616005021 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 391616005022 homotrimer interaction site [polypeptide binding]; other site 391616005023 zinc binding site [ion binding]; other site 391616005024 CDP-binding sites; other site 391616005025 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391616005026 Dihydrouridine synthase (Dus); Region: Dus; pfam01207 391616005027 FMN binding site [chemical binding]; other site 391616005028 active site 391616005029 catalytic residues [active] 391616005030 substrate binding site [chemical binding]; other site 391616005031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391616005032 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391616005033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616005034 dimer interface [polypeptide binding]; other site 391616005035 phosphorylation site [posttranslational modification] 391616005036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616005037 ATP binding site [chemical binding]; other site 391616005038 Mg2+ binding site [ion binding]; other site 391616005039 G-X-G motif; other site 391616005040 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 391616005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616005042 active site 391616005043 phosphorylation site [posttranslational modification] 391616005044 intermolecular recognition site; other site 391616005045 dimerization interface [polypeptide binding]; other site 391616005046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616005047 Walker A motif; other site 391616005048 ATP binding site [chemical binding]; other site 391616005049 Walker B motif; other site 391616005050 arginine finger; other site 391616005051 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391616005052 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 391616005053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391616005054 dimerization interface [polypeptide binding]; other site 391616005055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616005056 dimer interface [polypeptide binding]; other site 391616005057 phosphorylation site [posttranslational modification] 391616005058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616005059 ATP binding site [chemical binding]; other site 391616005060 Mg2+ binding site [ion binding]; other site 391616005061 G-X-G motif; other site 391616005062 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391616005063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616005064 active site 391616005065 phosphorylation site [posttranslational modification] 391616005066 intermolecular recognition site; other site 391616005067 dimerization interface [polypeptide binding]; other site 391616005068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616005069 Walker A motif; other site 391616005070 ATP binding site [chemical binding]; other site 391616005071 Walker B motif; other site 391616005072 arginine finger; other site 391616005073 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391616005074 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 391616005075 TrkA-N domain; Region: TrkA_N; pfam02254 391616005076 TrkA-C domain; Region: TrkA_C; pfam02080 391616005077 TrkA-N domain; Region: TrkA_N; pfam02254 391616005078 TrkA-C domain; Region: TrkA_C; pfam02080 391616005079 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391616005080 Cation transport protein; Region: TrkH; cl17365 391616005081 bacterial Hfq-like; Region: Hfq; cd01716 391616005082 hexamer interface [polypeptide binding]; other site 391616005083 Sm1 motif; other site 391616005084 RNA binding site [nucleotide binding]; other site 391616005085 Sm2 motif; other site 391616005086 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 391616005087 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 391616005088 HflX GTPase family; Region: HflX; cd01878 391616005089 G1 box; other site 391616005090 GTP/Mg2+ binding site [chemical binding]; other site 391616005091 Switch I region; other site 391616005092 G2 box; other site 391616005093 G3 box; other site 391616005094 Switch II region; other site 391616005095 G4 box; other site 391616005096 G5 box; other site 391616005097 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391616005098 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391616005099 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391616005100 active site 391616005101 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391616005102 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616005103 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616005104 Class I aldolases; Region: Aldolase_Class_I; cl17187 391616005105 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391616005106 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391616005107 conserved cys residue [active] 391616005108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616005109 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391616005110 PAS domain; Region: PAS_5; pfam07310 391616005111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 391616005112 hypothetical protein; Provisional; Region: PRK11820 391616005113 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 391616005114 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 391616005115 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 391616005116 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 391616005117 catalytic site [active] 391616005118 G-X2-G-X-G-K; other site 391616005119 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 391616005120 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 391616005121 trimer interface [polypeptide binding]; other site 391616005122 putative metal binding site [ion binding]; other site 391616005123 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391616005124 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616005125 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616005126 catalytic residue [active] 391616005127 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391616005128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616005129 dimer interface [polypeptide binding]; other site 391616005130 phosphorylation site [posttranslational modification] 391616005131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616005132 ATP binding site [chemical binding]; other site 391616005133 Mg2+ binding site [ion binding]; other site 391616005134 G-X-G motif; other site 391616005135 PBP superfamily domain; Region: PBP_like_2; pfam12849 391616005136 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 391616005137 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 391616005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005139 dimer interface [polypeptide binding]; other site 391616005140 conserved gate region; other site 391616005141 putative PBP binding loops; other site 391616005142 ABC-ATPase subunit interface; other site 391616005143 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 391616005144 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 391616005145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005146 dimer interface [polypeptide binding]; other site 391616005147 conserved gate region; other site 391616005148 putative PBP binding loops; other site 391616005149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616005150 ABC-ATPase subunit interface; other site 391616005151 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 391616005152 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 391616005153 Walker A/P-loop; other site 391616005154 ATP binding site [chemical binding]; other site 391616005155 Q-loop/lid; other site 391616005156 ABC transporter signature motif; other site 391616005157 Walker B; other site 391616005158 D-loop; other site 391616005159 H-loop/switch region; other site 391616005160 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 391616005161 PhoU domain; Region: PhoU; pfam01895 391616005162 PhoU domain; Region: PhoU; pfam01895 391616005163 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 391616005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616005165 active site 391616005166 phosphorylation site [posttranslational modification] 391616005167 intermolecular recognition site; other site 391616005168 dimerization interface [polypeptide binding]; other site 391616005169 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616005170 DNA binding site [nucleotide binding] 391616005171 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391616005172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005173 dimer interface [polypeptide binding]; other site 391616005174 conserved gate region; other site 391616005175 putative PBP binding loops; other site 391616005176 ABC-ATPase subunit interface; other site 391616005177 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616005178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005179 dimer interface [polypeptide binding]; other site 391616005180 conserved gate region; other site 391616005181 putative PBP binding loops; other site 391616005182 ABC-ATPase subunit interface; other site 391616005183 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391616005184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616005185 Walker A/P-loop; other site 391616005186 ATP binding site [chemical binding]; other site 391616005187 Q-loop/lid; other site 391616005188 ABC transporter signature motif; other site 391616005189 Walker B; other site 391616005190 D-loop; other site 391616005191 H-loop/switch region; other site 391616005192 TOBE domain; Region: TOBE_2; pfam08402 391616005193 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 391616005194 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616005195 putative aminotransferase; Validated; Region: PRK07480 391616005196 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616005197 inhibitor-cofactor binding pocket; inhibition site 391616005198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616005199 catalytic residue [active] 391616005200 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391616005201 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616005202 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391616005203 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391616005204 heme binding site [chemical binding]; other site 391616005205 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 391616005206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391616005207 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616005208 Walker A/P-loop; other site 391616005209 ATP binding site [chemical binding]; other site 391616005210 Q-loop/lid; other site 391616005211 ABC transporter signature motif; other site 391616005212 Walker B; other site 391616005213 D-loop; other site 391616005214 H-loop/switch region; other site 391616005215 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391616005216 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616005217 Walker A/P-loop; other site 391616005218 ATP binding site [chemical binding]; other site 391616005219 Q-loop/lid; other site 391616005220 ABC transporter signature motif; other site 391616005221 Walker B; other site 391616005222 D-loop; other site 391616005223 H-loop/switch region; other site 391616005224 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616005225 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616005226 TM-ABC transporter signature motif; other site 391616005227 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616005228 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616005229 TM-ABC transporter signature motif; other site 391616005230 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616005231 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 391616005232 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391616005233 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391616005234 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005235 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005236 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005237 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616005238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005239 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616005240 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616005241 Transposase; Region: HTH_Tnp_1; pfam01527 391616005242 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616005243 MULE transposase domain; Region: MULE; pfam10551 391616005244 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391616005245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391616005246 DNA binding residues [nucleotide binding] 391616005247 dimerization interface [polypeptide binding]; other site 391616005248 elongation factor Ts; Provisional; Region: tsf; PRK09377 391616005249 UBA/TS-N domain; Region: UBA; pfam00627 391616005250 Elongation factor TS; Region: EF_TS; pfam00889 391616005251 Elongation factor TS; Region: EF_TS; pfam00889 391616005252 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391616005253 rRNA interaction site [nucleotide binding]; other site 391616005254 S8 interaction site; other site 391616005255 putative laminin-1 binding site; other site 391616005256 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005257 Integrase core domain; Region: rve; pfam00665 391616005258 Integrase core domain; Region: rve_3; pfam13683 391616005259 Integrase core domain; Region: rve; pfam00665 391616005260 Integrase core domain; Region: rve_3; pfam13683 391616005261 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 391616005262 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391616005263 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 391616005264 Transposase; Region: HTH_Tnp_1; cl17663 391616005265 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005267 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005268 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391616005269 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391616005270 putative acyl-acceptor binding pocket; other site 391616005271 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616005272 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 391616005273 substrate binding site [chemical binding]; other site 391616005274 ATP binding site [chemical binding]; other site 391616005275 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 391616005276 Uncharacterized conserved protein [Function unknown]; Region: COG2928 391616005277 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 391616005278 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 391616005279 active site 391616005280 nucleophile elbow; other site 391616005281 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 391616005282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616005283 NAD(P) binding site [chemical binding]; other site 391616005284 active site 391616005285 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391616005286 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391616005287 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391616005288 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391616005289 active site 391616005290 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 391616005291 amphipathic channel; other site 391616005292 Asn-Pro-Ala signature motifs; other site 391616005293 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005294 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391616005295 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391616005296 acyl-activating enzyme (AAE) consensus motif; other site 391616005297 AMP binding site [chemical binding]; other site 391616005298 active site 391616005299 CoA binding site [chemical binding]; other site 391616005300 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391616005301 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391616005302 catalytic residues [active] 391616005303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616005304 putative substrate translocation pore; other site 391616005305 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391616005306 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 391616005307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616005308 ATP binding site [chemical binding]; other site 391616005309 putative Mg++ binding site [ion binding]; other site 391616005310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616005311 nucleotide binding region [chemical binding]; other site 391616005312 ATP-binding site [chemical binding]; other site 391616005313 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 391616005314 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 391616005315 dimer interface [polypeptide binding]; other site 391616005316 active site 391616005317 aspartate-rich active site metal binding site; other site 391616005318 allosteric magnesium binding site [ion binding]; other site 391616005319 Schiff base residues; other site 391616005320 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 391616005321 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616005322 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616005323 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616005324 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616005325 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616005326 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616005327 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616005328 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616005329 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391616005330 Ligand binding site; other site 391616005331 metal-binding site 391616005332 Integrase core domain; Region: rve; pfam00665 391616005333 Integrase core domain; Region: rve_3; pfam13683 391616005334 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616005335 Flavodoxin domain; Region: Flavodoxin_5; cl17428 391616005336 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 391616005337 putative ATP binding site [chemical binding]; other site 391616005338 putative substrate binding site [chemical binding]; other site 391616005339 Integrase core domain; Region: rve; pfam00665 391616005340 Integrase core domain; Region: rve_3; pfam13683 391616005341 Transposase; Region: HTH_Tnp_1; pfam01527 391616005342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616005343 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616005344 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391616005345 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391616005346 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616005347 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616005348 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391616005349 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391616005350 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616005351 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 391616005352 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 391616005353 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 391616005354 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391616005355 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391616005356 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391616005357 FMN binding site [chemical binding]; other site 391616005358 active site 391616005359 catalytic residues [active] 391616005360 substrate binding site [chemical binding]; other site 391616005361 Integrase core domain; Region: rve; pfam00665 391616005362 Integrase core domain; Region: rve_3; pfam13683 391616005363 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616005365 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616005366 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391616005367 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616005368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616005369 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616005370 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616005371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616005372 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616005373 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616005375 Transposase; Region: HTH_Tnp_1; pfam01527 391616005376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616005377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616005378 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616005379 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616005380 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616005381 Integrase core domain; Region: rve; pfam00665 391616005382 Integrase core domain; Region: rve_3; pfam13683 391616005383 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 391616005384 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 391616005385 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 391616005386 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391616005387 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391616005388 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391616005389 dimer interface [polypeptide binding]; other site 391616005390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616005391 catalytic residue [active] 391616005392 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391616005393 putative active site pocket [active] 391616005394 dimerization interface [polypeptide binding]; other site 391616005395 putative catalytic residue [active] 391616005396 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 391616005397 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391616005398 dimer interface [polypeptide binding]; other site 391616005399 ADP-ribose binding site [chemical binding]; other site 391616005400 active site 391616005401 nudix motif; other site 391616005402 metal binding site [ion binding]; metal-binding site 391616005403 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 391616005404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616005405 S-adenosylmethionine binding site [chemical binding]; other site 391616005406 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391616005407 DNA photolyase; Region: DNA_photolyase; pfam00875 391616005408 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 391616005409 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 391616005410 NADP binding site [chemical binding]; other site 391616005411 dimer interface [polypeptide binding]; other site 391616005412 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391616005413 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616005414 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 391616005415 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 391616005416 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391616005417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616005418 DNA-binding site [nucleotide binding]; DNA binding site 391616005419 FCD domain; Region: FCD; pfam07729 391616005420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005421 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005422 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005423 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616005424 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005425 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616005426 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 391616005427 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616005428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616005429 putative DNA binding site [nucleotide binding]; other site 391616005430 putative Zn2+ binding site [ion binding]; other site 391616005431 AsnC family; Region: AsnC_trans_reg; pfam01037 391616005432 siroheme synthase; Provisional; Region: cysG; PRK10637 391616005433 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 391616005434 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391616005435 active site 391616005436 SAM binding site [chemical binding]; other site 391616005437 homodimer interface [polypeptide binding]; other site 391616005438 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 391616005439 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391616005440 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391616005441 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391616005442 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 391616005443 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391616005444 Active Sites [active] 391616005445 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 391616005446 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391616005447 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391616005448 FAD binding pocket [chemical binding]; other site 391616005449 FAD binding motif [chemical binding]; other site 391616005450 phosphate binding motif [ion binding]; other site 391616005451 beta-alpha-beta structure motif; other site 391616005452 NAD binding pocket [chemical binding]; other site 391616005453 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005454 Integrase core domain; Region: rve; pfam00665 391616005455 Integrase core domain; Region: rve_3; cl15866 391616005456 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 391616005457 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391616005458 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391616005459 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391616005460 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616005461 ligand binding site [chemical binding]; other site 391616005462 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005463 Integrase core domain; Region: rve; pfam00665 391616005464 Integrase core domain; Region: rve_3; pfam13683 391616005465 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005466 Homeodomain-like domain; Region: HTH_32; pfam13565 391616005467 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005468 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616005469 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616005470 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005471 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005472 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391616005473 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391616005474 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391616005475 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391616005476 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616005477 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391616005478 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391616005479 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391616005480 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 391616005481 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391616005482 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391616005483 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391616005484 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 391616005485 Hint domain; Region: Hint_2; pfam13403 391616005486 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 391616005487 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 391616005488 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 391616005489 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616005490 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616005491 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616005492 Integrase core domain; Region: rve; pfam00665 391616005493 Integrase core domain; Region: rve_3; pfam13683 391616005494 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616005495 Integrase core domain; Region: rve; pfam00665 391616005496 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616005497 Restriction endonuclease; Region: Mrr_cat; pfam04471 391616005498 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 391616005499 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616005500 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616005501 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616005502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616005503 Transposase; Region: HTH_Tnp_1; pfam01527 391616005504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005505 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616005506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616005507 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005508 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005509 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616005510 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005511 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005512 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005514 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616005515 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616005516 Integrase core domain; Region: rve; pfam00665 391616005517 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391616005518 active site 391616005519 metal binding site [ion binding]; metal-binding site 391616005520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616005521 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616005522 hypothetical protein; Provisional; Region: PRK10396 391616005523 Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173 391616005524 SEC-C motif; Region: SEC-C; pfam02810 391616005525 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 391616005526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616005527 MULE transposase domain; Region: MULE; pfam10551 391616005528 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 391616005529 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616005530 ATP binding site [chemical binding]; other site 391616005531 putative Mg++ binding site [ion binding]; other site 391616005532 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616005533 nucleotide binding region [chemical binding]; other site 391616005534 ATP-binding site [chemical binding]; other site 391616005535 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616005536 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 391616005537 active site 391616005538 catalytic site [active] 391616005539 substrate binding site [chemical binding]; other site 391616005540 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 391616005541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616005542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616005543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616005544 dimerization interface [polypeptide binding]; other site 391616005545 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391616005546 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391616005547 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391616005548 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391616005549 Walker A/P-loop; other site 391616005550 ATP binding site [chemical binding]; other site 391616005551 Q-loop/lid; other site 391616005552 ABC transporter signature motif; other site 391616005553 Walker B; other site 391616005554 D-loop; other site 391616005555 H-loop/switch region; other site 391616005556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005557 dimer interface [polypeptide binding]; other site 391616005558 conserved gate region; other site 391616005559 putative PBP binding loops; other site 391616005560 ABC-ATPase subunit interface; other site 391616005561 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 391616005562 agmatinase; Region: agmatinase; TIGR01230 391616005563 active site 391616005564 metal binding site [ion binding]; metal-binding site 391616005565 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391616005566 agmatinase; Region: agmatinase; TIGR01230 391616005567 oligomer interface [polypeptide binding]; other site 391616005568 putative active site [active] 391616005569 Mn binding site [ion binding]; other site 391616005570 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391616005571 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391616005572 active site 391616005573 DNA binding site [nucleotide binding] 391616005574 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391616005575 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391616005576 Catalytic site [active] 391616005577 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005578 Integrase core domain; Region: rve; pfam00665 391616005579 Integrase core domain; Region: rve_3; pfam13683 391616005580 putative transposase OrfB; Reviewed; Region: PHA02517 391616005581 Integrase core domain; Region: rve; pfam00665 391616005582 Integrase core domain; Region: rve_3; pfam13683 391616005583 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391616005584 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 391616005585 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 391616005586 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 391616005587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616005588 Integrase core domain; Region: rve; pfam00665 391616005589 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616005590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616005591 Walker A motif; other site 391616005592 ATP binding site [chemical binding]; other site 391616005593 Walker B motif; other site 391616005594 arginine finger; other site 391616005595 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005596 Integrase core domain; Region: rve; pfam00665 391616005597 Integrase core domain; Region: rve_3; pfam13683 391616005598 Predicted membrane protein [Function unknown]; Region: COG1238 391616005599 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391616005600 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616005601 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391616005602 AsnC family; Region: AsnC_trans_reg; pfam01037 391616005603 Arginase family; Region: Arginase; cd09989 391616005604 agmatinase; Region: agmatinase; TIGR01230 391616005605 active site 391616005606 Mn binding site [ion binding]; other site 391616005607 oligomer interface [polypeptide binding]; other site 391616005608 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 391616005609 Amidinotransferase; Region: Amidinotransf; pfam02274 391616005610 ornithine cyclodeaminase; Validated; Region: PRK07589 391616005611 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391616005612 DNA gyrase subunit A; Validated; Region: PRK05560 391616005613 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391616005614 CAP-like domain; other site 391616005615 active site 391616005616 primary dimer interface [polypeptide binding]; other site 391616005617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616005618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616005619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616005620 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616005621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391616005622 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391616005623 Glucose inhibited division protein A; Region: GIDA; pfam01134 391616005624 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 391616005625 active site 391616005626 HIGH motif; other site 391616005627 nucleotide binding site [chemical binding]; other site 391616005628 active site 391616005629 KMSKS motif; other site 391616005630 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 391616005631 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 391616005632 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391616005633 trimerization site [polypeptide binding]; other site 391616005634 active site 391616005635 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391616005636 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391616005637 generic binding surface II; other site 391616005638 ssDNA binding site; other site 391616005639 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616005640 ATP binding site [chemical binding]; other site 391616005641 putative Mg++ binding site [ion binding]; other site 391616005642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616005643 nucleotide binding region [chemical binding]; other site 391616005644 ATP-binding site [chemical binding]; other site 391616005645 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391616005646 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391616005647 nucleotide binding pocket [chemical binding]; other site 391616005648 K-X-D-G motif; other site 391616005649 catalytic site [active] 391616005650 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391616005651 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391616005652 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 391616005653 Dimer interface [polypeptide binding]; other site 391616005654 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005655 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005656 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005657 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005659 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 391616005660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616005661 active site 391616005662 phosphorylation site [posttranslational modification] 391616005663 intermolecular recognition site; other site 391616005664 dimerization interface [polypeptide binding]; other site 391616005665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616005666 DNA binding site [nucleotide binding] 391616005667 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 391616005668 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 391616005669 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 391616005670 Ligand Binding Site [chemical binding]; other site 391616005671 Protein of unknown function (DUF971); Region: DUF971; cl01414 391616005672 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 391616005673 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 391616005674 substrate binding pocket [chemical binding]; other site 391616005675 active site 391616005676 iron coordination sites [ion binding]; other site 391616005677 Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454 391616005678 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005679 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005680 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005681 Homeodomain-like domain; Region: HTH_32; pfam13565 391616005682 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005683 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005684 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005685 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391616005686 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 391616005687 substrate binding pocket [chemical binding]; other site 391616005688 dimer interface [polypeptide binding]; other site 391616005689 inhibitor binding site; inhibition site 391616005690 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 391616005691 FAD binding site [chemical binding]; other site 391616005692 Virulence factor; Region: Virulence_fact; pfam13769 391616005693 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391616005694 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391616005695 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391616005696 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 391616005697 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 391616005698 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 391616005699 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 391616005700 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 391616005701 active site 391616005702 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 391616005703 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 391616005704 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 391616005705 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391616005706 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391616005707 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391616005708 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391616005709 Surface antigen; Region: Bac_surface_Ag; pfam01103 391616005710 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391616005711 RIP metalloprotease RseP; Region: TIGR00054 391616005712 active site 391616005713 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 391616005714 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 391616005715 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391616005716 putative substrate binding region [chemical binding]; other site 391616005717 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391616005718 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391616005719 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391616005720 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 391616005721 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391616005722 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 391616005723 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 391616005724 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 391616005725 catalytic residue [active] 391616005726 putative FPP diphosphate binding site; other site 391616005727 putative FPP binding hydrophobic cleft; other site 391616005728 dimer interface [polypeptide binding]; other site 391616005729 putative IPP diphosphate binding site; other site 391616005730 ribosome recycling factor; Reviewed; Region: frr; PRK00083 391616005731 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 391616005732 hinge region; other site 391616005733 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 391616005734 putative nucleotide binding site [chemical binding]; other site 391616005735 uridine monophosphate binding site [chemical binding]; other site 391616005736 homohexameric interface [polypeptide binding]; other site 391616005737 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 391616005738 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 391616005739 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391616005740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616005741 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391616005742 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391616005743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391616005744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005745 dimer interface [polypeptide binding]; other site 391616005746 conserved gate region; other site 391616005747 putative PBP binding loops; other site 391616005748 ABC-ATPase subunit interface; other site 391616005749 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391616005750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616005751 conserved gate region; other site 391616005752 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391616005753 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616005754 Walker A/P-loop; other site 391616005755 ATP binding site [chemical binding]; other site 391616005756 Q-loop/lid; other site 391616005757 ABC transporter signature motif; other site 391616005758 Walker B; other site 391616005759 D-loop; other site 391616005760 H-loop/switch region; other site 391616005761 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616005762 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616005763 Walker A/P-loop; other site 391616005764 ATP binding site [chemical binding]; other site 391616005765 Q-loop/lid; other site 391616005766 ABC transporter signature motif; other site 391616005767 Walker B; other site 391616005768 D-loop; other site 391616005769 H-loop/switch region; other site 391616005770 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616005771 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391616005772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616005773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616005774 catalytic residue [active] 391616005775 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005776 Homeodomain-like domain; Region: HTH_32; pfam13565 391616005777 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005778 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005779 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005780 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391616005781 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391616005782 dimer interface [polypeptide binding]; other site 391616005783 ssDNA binding site [nucleotide binding]; other site 391616005784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391616005785 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391616005786 active site 391616005787 dimer interface [polypeptide binding]; other site 391616005788 metal binding site [ion binding]; metal-binding site 391616005789 shikimate kinase; Provisional; Region: PRK13946 391616005790 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 391616005791 ADP binding site [chemical binding]; other site 391616005792 magnesium binding site [ion binding]; other site 391616005793 putative shikimate binding site; other site 391616005794 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391616005795 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616005796 active site 391616005797 DNA binding site [nucleotide binding] 391616005798 Int/Topo IB signature motif; other site 391616005799 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 391616005800 Domain of unknown function DUF21; Region: DUF21; pfam01595 391616005801 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391616005802 Transporter associated domain; Region: CorC_HlyC; smart01091 391616005803 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 391616005804 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 391616005805 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391616005806 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391616005807 dimer interface [polypeptide binding]; other site 391616005808 active site 391616005809 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 391616005810 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 391616005811 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 391616005812 trimer interface [polypeptide binding]; other site 391616005813 active site 391616005814 UDP-GlcNAc binding site [chemical binding]; other site 391616005815 lipid binding site [chemical binding]; lipid-binding site 391616005816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 391616005817 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391616005818 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391616005819 Peptidase M15; Region: Peptidase_M15_3; cl01194 391616005820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391616005821 Uncharacterized family of heme peroxidases, mostly bacterial; Region: peroxinectin_like_bacterial; cd09822 391616005822 putative heme binding site [chemical binding]; other site 391616005823 putative substrate binding site [chemical binding]; other site 391616005824 Hint domain; Region: Hint_2; pfam13403 391616005825 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616005826 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616005827 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616005828 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 391616005829 Hint domain; Region: Hint_2; pfam13403 391616005830 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391616005831 homotrimer interaction site [polypeptide binding]; other site 391616005832 putative active site [active] 391616005833 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391616005834 active site 391616005835 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 391616005836 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 391616005837 active site 391616005838 dimer interface [polypeptide binding]; other site 391616005839 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 391616005840 dimer interface [polypeptide binding]; other site 391616005841 active site 391616005842 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 391616005843 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 391616005844 putative active site [active] 391616005845 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391616005846 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391616005847 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391616005848 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 391616005849 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391616005850 active site 391616005851 Predicted esterase [General function prediction only]; Region: COG0400 391616005852 putative hydrolase; Provisional; Region: PRK11460 391616005853 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391616005854 endonuclease III; Region: ENDO3c; smart00478 391616005855 minor groove reading motif; other site 391616005856 helix-hairpin-helix signature motif; other site 391616005857 substrate binding pocket [chemical binding]; other site 391616005858 active site 391616005859 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 391616005860 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 391616005861 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 391616005862 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391616005863 active site 391616005864 SAM binding site [chemical binding]; other site 391616005865 homodimer interface [polypeptide binding]; other site 391616005866 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 391616005867 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 391616005868 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 391616005869 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616005870 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391616005871 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 391616005872 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 391616005873 active site 391616005874 catalytic residues [active] 391616005875 metal binding site [ion binding]; metal-binding site 391616005876 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391616005877 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391616005878 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616005879 active site 391616005880 HIGH motif; other site 391616005881 nucleotide binding site [chemical binding]; other site 391616005882 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391616005883 KMSKS motif; other site 391616005884 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 391616005885 tRNA binding surface [nucleotide binding]; other site 391616005886 anticodon binding site; other site 391616005887 Protein of unknown function (DUF419); Region: DUF419; pfam04237 391616005888 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 391616005889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616005890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616005891 homodimer interface [polypeptide binding]; other site 391616005892 catalytic residue [active] 391616005893 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391616005894 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391616005895 tetramer interface [polypeptide binding]; other site 391616005896 active site 391616005897 Mg2+/Mn2+ binding site [ion binding]; other site 391616005898 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 391616005899 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 391616005900 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391616005901 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391616005902 active site 391616005903 HIGH motif; other site 391616005904 dimer interface [polypeptide binding]; other site 391616005905 KMSKS motif; other site 391616005906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616005907 RNA binding surface [nucleotide binding]; other site 391616005908 Winged helix-turn helix; Region: HTH_29; pfam13551 391616005909 Winged helix-turn helix; Region: HTH_33; pfam13592 391616005910 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616005911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616005912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 391616005913 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391616005914 metal binding site 2 [ion binding]; metal-binding site 391616005915 putative DNA binding helix; other site 391616005916 metal binding site 1 [ion binding]; metal-binding site 391616005917 dimer interface [polypeptide binding]; other site 391616005918 structural Zn2+ binding site [ion binding]; other site 391616005919 enolase; Provisional; Region: eno; PRK00077 391616005920 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391616005921 dimer interface [polypeptide binding]; other site 391616005922 metal binding site [ion binding]; metal-binding site 391616005923 substrate binding pocket [chemical binding]; other site 391616005924 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616005925 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 391616005926 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 391616005927 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 391616005928 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391616005929 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391616005930 active site 391616005931 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391616005932 TSCPD domain; Region: TSCPD; pfam12637 391616005933 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 391616005934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391616005935 DNA-binding site [nucleotide binding]; DNA binding site 391616005936 RNA-binding motif; other site 391616005937 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391616005938 DNA-binding site [nucleotide binding]; DNA binding site 391616005939 RNA-binding motif; other site 391616005940 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391616005941 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 391616005942 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391616005943 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 391616005944 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391616005945 NAD binding site [chemical binding]; other site 391616005946 homotetramer interface [polypeptide binding]; other site 391616005947 homodimer interface [polypeptide binding]; other site 391616005948 substrate binding site [chemical binding]; other site 391616005949 active site 391616005950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616005951 active site 391616005952 hypothetical protein; Provisional; Region: PRK07550 391616005953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616005954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616005955 homodimer interface [polypeptide binding]; other site 391616005956 catalytic residue [active] 391616005957 SurA N-terminal domain; Region: SurA_N_3; cl07813 391616005958 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 391616005959 anthranilate synthase component I; Provisional; Region: PRK13573 391616005960 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391616005961 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391616005962 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl17042 391616005963 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391616005964 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391616005965 glutamine binding [chemical binding]; other site 391616005966 catalytic triad [active] 391616005967 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 391616005968 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391616005969 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391616005970 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616005971 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616005972 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 391616005973 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391616005974 active site 391616005975 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391616005976 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 391616005977 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391616005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 391616005979 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 391616005980 Uncharacterized conserved protein [Function unknown]; Region: COG2308 391616005981 TfoX C-terminal domain; Region: TfoX_C; pfam04994 391616005982 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391616005983 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616005984 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616005985 catalytic residue [active] 391616005986 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391616005987 active site 391616005988 multimer interface [polypeptide binding]; other site 391616005989 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391616005990 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616005991 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616005992 ABC transporter; Region: ABC_tran_2; pfam12848 391616005993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616005994 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 391616005995 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 391616005996 catalytic motif [active] 391616005997 Catalytic residue [active] 391616005998 DNA polymerase III subunit chi; Validated; Region: PRK05728 391616005999 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391616006000 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391616006001 interface (dimer of trimers) [polypeptide binding]; other site 391616006002 Substrate-binding/catalytic site; other site 391616006003 Zn-binding sites [ion binding]; other site 391616006004 Predicted permeases [General function prediction only]; Region: COG0795 391616006005 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391616006006 Predicted permeases [General function prediction only]; Region: COG0795 391616006007 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391616006008 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 391616006009 Organic solvent tolerance protein; Region: OstA_C; pfam04453 391616006010 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 391616006011 SurA N-terminal domain; Region: SurA_N; pfam09312 391616006012 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391616006013 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 391616006014 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391616006015 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 391616006016 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 391616006017 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 391616006018 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 391616006019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616006020 S-adenosylmethionine binding site [chemical binding]; other site 391616006021 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391616006022 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391616006023 RF-1 domain; Region: RF-1; pfam00472 391616006024 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 391616006025 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391616006026 agmatinase; Region: agmatinase; TIGR01230 391616006027 oligomer interface [polypeptide binding]; other site 391616006028 putative active site [active] 391616006029 Mn binding site [ion binding]; other site 391616006030 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391616006031 agmatinase; Region: agmatinase; TIGR01230 391616006032 oligomer interface [polypeptide binding]; other site 391616006033 putative active site [active] 391616006034 Mn binding site [ion binding]; other site 391616006035 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391616006036 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391616006037 metal binding site [ion binding]; metal-binding site 391616006038 putative dimer interface [polypeptide binding]; other site 391616006039 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 391616006040 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 391616006041 homodimer interface [polypeptide binding]; other site 391616006042 metal binding site [ion binding]; metal-binding site 391616006043 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 391616006044 homodimer interface [polypeptide binding]; other site 391616006045 active site 391616006046 putative chemical substrate binding site [chemical binding]; other site 391616006047 metal binding site [ion binding]; metal-binding site 391616006048 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391616006049 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616006050 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616006051 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 391616006052 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 391616006053 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 391616006054 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 391616006055 putative phosphate acyltransferase; Provisional; Region: PRK05331 391616006056 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391616006057 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391616006058 dimer interface [polypeptide binding]; other site 391616006059 active site 391616006060 CoA binding pocket [chemical binding]; other site 391616006061 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391616006062 IHF dimer interface [polypeptide binding]; other site 391616006063 IHF - DNA interface [nucleotide binding]; other site 391616006064 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 391616006065 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391616006066 DNA binding residues [nucleotide binding] 391616006067 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 391616006068 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391616006069 trimer interface [polypeptide binding]; other site 391616006070 active site 391616006071 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391616006072 trimer interface [polypeptide binding]; other site 391616006073 active site 391616006074 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 391616006075 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 391616006076 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391616006077 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391616006078 Sporulation related domain; Region: SPOR; pfam05036 391616006079 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 391616006080 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 391616006081 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391616006082 active site 391616006083 HIGH motif; other site 391616006084 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616006085 KMSK motif region; other site 391616006086 tRNA binding surface [nucleotide binding]; other site 391616006087 DALR anticodon binding domain; Region: DALR_1; smart00836 391616006088 anticodon binding site; other site 391616006089 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 391616006090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391616006091 Zn2+ binding site [ion binding]; other site 391616006092 Mg2+ binding site [ion binding]; other site 391616006093 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 391616006094 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 391616006095 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391616006096 putative catalytic site [active] 391616006097 putative phosphate binding site [ion binding]; other site 391616006098 active site 391616006099 metal binding site A [ion binding]; metal-binding site 391616006100 DNA binding site [nucleotide binding] 391616006101 putative AP binding site [nucleotide binding]; other site 391616006102 putative metal binding site B [ion binding]; other site 391616006103 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391616006104 salicylate hydroxylase; Provisional; Region: PRK08163 391616006105 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 391616006106 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616006107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616006108 Walker A motif; other site 391616006109 ATP binding site [chemical binding]; other site 391616006110 Walker B motif; other site 391616006111 arginine finger; other site 391616006112 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391616006113 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391616006114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 391616006115 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391616006116 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391616006117 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616006118 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616006119 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616006120 active site 391616006121 Peptidase family M48; Region: Peptidase_M48; cl12018 391616006122 PIN domain; Region: PIN_3; pfam13470 391616006123 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 391616006124 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 391616006125 putative RNA binding site [nucleotide binding]; other site 391616006126 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391616006127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616006128 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006129 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006130 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616006131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616006132 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616006133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616006134 Transposase; Region: HTH_Tnp_1; pfam01527 391616006135 phosphogluconate dehydratase; Validated; Region: PRK09054 391616006136 6-phosphogluconate dehydratase; Region: edd; TIGR01196 391616006137 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 391616006138 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391616006139 active site 391616006140 intersubunit interface [polypeptide binding]; other site 391616006141 catalytic residue [active] 391616006142 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 391616006143 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391616006144 metal binding triad; other site 391616006145 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391616006146 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391616006147 metal binding triad; other site 391616006148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616006149 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006150 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616006151 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 391616006152 putative deacylase active site [active] 391616006153 Integrase core domain; Region: rve; pfam00665 391616006154 Integrase core domain; Region: rve_3; pfam13683 391616006155 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391616006156 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391616006157 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 391616006158 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 391616006159 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 391616006160 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616006161 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616006162 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391616006163 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 391616006164 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616006165 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006166 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006167 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 391616006168 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616006169 PYR/PP interface [polypeptide binding]; other site 391616006170 dimer interface [polypeptide binding]; other site 391616006171 TPP binding site [chemical binding]; other site 391616006172 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391616006173 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391616006174 TPP-binding site [chemical binding]; other site 391616006175 dimer interface [polypeptide binding]; other site 391616006176 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391616006177 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391616006178 putative valine binding site [chemical binding]; other site 391616006179 dimer interface [polypeptide binding]; other site 391616006180 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391616006181 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 391616006182 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616006183 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391616006184 [2Fe-2S] cluster binding site [ion binding]; other site 391616006185 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391616006186 alpha subunit interface [polypeptide binding]; other site 391616006187 active site 391616006188 substrate binding site [chemical binding]; other site 391616006189 Fe binding site [ion binding]; other site 391616006190 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 391616006191 active site 391616006192 tetramer interface [polypeptide binding]; other site 391616006193 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006194 Integrase core domain; Region: rve; pfam00665 391616006195 Integrase core domain; Region: rve_3; pfam13683 391616006196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616006197 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006198 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616006199 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616006200 active site 391616006201 DNA binding site [nucleotide binding] 391616006202 Int/Topo IB signature motif; other site 391616006203 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006204 MULE transposase domain; Region: MULE; pfam10551 391616006205 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616006206 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006207 MULE transposase domain; Region: MULE; pfam10551 391616006208 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391616006209 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616006210 catalytic residues [active] 391616006211 catalytic nucleophile [active] 391616006212 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 391616006213 Sensors of blue-light using FAD; Region: BLUF; pfam04940 391616006214 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616006215 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616006216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616006217 active site 391616006218 DNA binding site [nucleotide binding] 391616006219 Int/Topo IB signature motif; other site 391616006220 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616006221 Putative transposase; Region: Y2_Tnp; pfam04986 391616006222 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006223 Homeodomain-like domain; Region: HTH_32; pfam13565 391616006224 Integrase core domain; Region: rve; pfam00665 391616006225 Integrase core domain; Region: rve_3; pfam13683 391616006226 Integrase core domain; Region: rve; pfam00665 391616006227 Integrase core domain; Region: rve_3; pfam13683 391616006228 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391616006229 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616006230 DNA-binding site [nucleotide binding]; DNA binding site 391616006231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616006232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616006233 homodimer interface [polypeptide binding]; other site 391616006234 catalytic residue [active] 391616006235 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616006236 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616006237 Walker A/P-loop; other site 391616006238 ATP binding site [chemical binding]; other site 391616006239 Q-loop/lid; other site 391616006240 ABC transporter signature motif; other site 391616006241 Walker B; other site 391616006242 D-loop; other site 391616006243 H-loop/switch region; other site 391616006244 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 391616006245 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616006246 substrate binding pocket [chemical binding]; other site 391616006247 membrane-bound complex binding site; other site 391616006248 hinge residues; other site 391616006249 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616006250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616006251 dimer interface [polypeptide binding]; other site 391616006252 conserved gate region; other site 391616006253 putative PBP binding loops; other site 391616006254 ABC-ATPase subunit interface; other site 391616006255 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391616006256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616006257 dimer interface [polypeptide binding]; other site 391616006258 conserved gate region; other site 391616006259 putative PBP binding loops; other site 391616006260 ABC-ATPase subunit interface; other site 391616006261 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391616006262 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391616006263 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391616006264 tetramer interface [polypeptide binding]; other site 391616006265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616006266 catalytic residue [active] 391616006267 ectoine utilization protein EutC; Validated; Region: PRK08291 391616006268 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391616006269 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391616006270 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616006271 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391616006272 active site 391616006273 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 391616006274 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 391616006275 putative active site [active] 391616006276 Zn binding site [ion binding]; other site 391616006277 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006278 MULE transposase domain; Region: MULE; pfam10551 391616006279 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006280 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006281 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006282 Homeodomain-like domain; Region: HTH_32; pfam13565 391616006283 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006284 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006285 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006286 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006287 MULE transposase domain; Region: MULE; pfam10551 391616006288 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006289 MULE transposase domain; Region: MULE; pfam10551 391616006290 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006292 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616006293 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616006294 Integrase core domain; Region: rve; pfam00665 391616006295 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391616006296 Maf-like protein; Region: Maf; pfam02545 391616006297 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391616006298 active site 391616006299 dimer interface [polypeptide binding]; other site 391616006300 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391616006301 rRNA binding site [nucleotide binding]; other site 391616006302 predicted 30S ribosome binding site; other site 391616006303 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391616006304 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391616006305 active site 391616006306 hypothetical protein; Provisional; Region: PRK02853 391616006307 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391616006308 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391616006309 NAD binding site [chemical binding]; other site 391616006310 dimerization interface [polypeptide binding]; other site 391616006311 product binding site; other site 391616006312 substrate binding site [chemical binding]; other site 391616006313 zinc binding site [ion binding]; other site 391616006314 catalytic residues [active] 391616006315 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 391616006316 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391616006317 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391616006318 hinge; other site 391616006319 active site 391616006320 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006321 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006322 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006323 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006324 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006325 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006326 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006327 MULE transposase domain; Region: MULE; pfam10551 391616006328 Integrase core domain; Region: rve; pfam00665 391616006329 Integrase core domain; Region: rve_3; pfam13683 391616006330 RNA dependent RNA polymerase; Region: RdRP_2; pfam00978 391616006331 Viral late protein H2; Region: Pox_LP_H2; cl17577 391616006332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616006333 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616006334 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616006335 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391616006336 AMP-binding domain protein; Validated; Region: PRK07529 391616006337 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391616006338 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 391616006339 acyl-activating enzyme (AAE) consensus motif; other site 391616006340 putative AMP binding site [chemical binding]; other site 391616006341 putative active site [active] 391616006342 putative CoA binding site [chemical binding]; other site 391616006343 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391616006344 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616006345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616006346 Walker A/P-loop; other site 391616006347 ATP binding site [chemical binding]; other site 391616006348 Q-loop/lid; other site 391616006349 ABC transporter signature motif; other site 391616006350 Walker B; other site 391616006351 D-loop; other site 391616006352 H-loop/switch region; other site 391616006353 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616006354 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616006355 Integrase core domain; Region: rve; pfam00665 391616006356 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006357 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006358 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006360 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391616006361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391616006362 active site 391616006363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616006364 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616006365 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616006366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616006367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616006368 DNA binding site [nucleotide binding] 391616006369 domain linker motif; other site 391616006370 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391616006371 putative dimerization interface [polypeptide binding]; other site 391616006372 putative ligand binding site [chemical binding]; other site 391616006373 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616006374 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616006375 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616006376 DctM-like transporters; Region: DctM; pfam06808 391616006377 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616006378 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391616006379 histidinol dehydrogenase; Region: hisD; TIGR00069 391616006380 NAD binding site [chemical binding]; other site 391616006381 dimerization interface [polypeptide binding]; other site 391616006382 product binding site; other site 391616006383 substrate binding site [chemical binding]; other site 391616006384 zinc binding site [ion binding]; other site 391616006385 catalytic residues [active] 391616006386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616006387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616006388 Integrase core domain; Region: rve; pfam00665 391616006389 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616006390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616006391 Walker A motif; other site 391616006392 ATP binding site [chemical binding]; other site 391616006393 Walker B motif; other site 391616006394 arginine finger; other site 391616006395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616006396 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616006397 active site 391616006398 catalytic tetrad [active] 391616006399 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616006400 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616006401 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391616006402 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616006403 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616006404 TM-ABC transporter signature motif; other site 391616006405 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616006406 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616006407 Walker A/P-loop; other site 391616006408 ATP binding site [chemical binding]; other site 391616006409 Q-loop/lid; other site 391616006410 ABC transporter signature motif; other site 391616006411 Walker B; other site 391616006412 D-loop; other site 391616006413 H-loop/switch region; other site 391616006414 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616006415 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391616006416 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391616006417 ligand binding site [chemical binding]; other site 391616006418 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391616006419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616006420 NAD(P) binding site [chemical binding]; other site 391616006421 active site 391616006422 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 391616006423 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391616006424 active site residue [active] 391616006425 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391616006426 active site residue [active] 391616006427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616006428 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391616006429 active site 391616006430 metal binding site [ion binding]; metal-binding site 391616006431 short chain dehydrogenase; Provisional; Region: PRK06123 391616006432 classical (c) SDRs; Region: SDR_c; cd05233 391616006433 NAD(P) binding site [chemical binding]; other site 391616006434 active site 391616006435 dihydroxy-acid dehydratase; Validated; Region: PRK06131 391616006436 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 391616006437 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 391616006438 active site 391616006439 catalytic residues [active] 391616006440 metal binding site [ion binding]; metal-binding site 391616006441 DmpG-like communication domain; Region: DmpG_comm; pfam07836 391616006442 acetaldehyde dehydrogenase; Validated; Region: PRK08300 391616006443 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391616006444 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 391616006445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391616006446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616006447 DNA-binding site [nucleotide binding]; DNA binding site 391616006448 FCD domain; Region: FCD; pfam07729 391616006449 Transposase; Region: HTH_Tnp_1; cl17663 391616006450 HTH-like domain; Region: HTH_21; pfam13276 391616006451 Integrase core domain; Region: rve; pfam00665 391616006452 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616006453 Sel1-like repeats; Region: SEL1; smart00671 391616006454 Helicase associated domain; Region: HA; pfam03457 391616006455 Helicase associated domain; Region: HA; pfam03457 391616006456 Helicase associated domain; Region: HA; pfam03457 391616006457 Helicase associated domain; Region: HA; pfam03457 391616006458 Helicase associated domain; Region: HA; pfam03457 391616006459 Integrase core domain; Region: rve; pfam00665 391616006460 Integrase core domain; Region: rve_3; pfam13683 391616006461 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391616006462 non-specific DNA interactions [nucleotide binding]; other site 391616006463 DNA binding site [nucleotide binding] 391616006464 sequence specific DNA binding site [nucleotide binding]; other site 391616006465 putative cAMP binding site [chemical binding]; other site 391616006466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391616006467 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 391616006468 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 391616006469 active site 391616006470 catalytic residues [active] 391616006471 metal binding site [ion binding]; metal-binding site 391616006472 DmpG-like communication domain; Region: DmpG_comm; pfam07836 391616006473 AMP-binding enzyme; Region: AMP-binding; pfam00501 391616006474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391616006475 acyl-activating enzyme (AAE) consensus motif; other site 391616006476 AMP binding site [chemical binding]; other site 391616006477 active site 391616006478 CoA binding site [chemical binding]; other site 391616006479 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391616006480 active site 391616006481 metal binding site [ion binding]; metal-binding site 391616006482 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 391616006483 peptide maturation system acyl carrier-related protein; Region: ocin_ACP_rel; TIGR04069 391616006484 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 391616006485 M28 Zn-Peptidases; Region: M28_like_3; cd05644 391616006486 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 391616006487 active site 391616006488 metal binding site [ion binding]; metal-binding site 391616006489 integrase; Provisional; Region: PRK09692 391616006490 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391616006491 active site 391616006492 Int/Topo IB signature motif; other site 391616006493 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616006494 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616006495 Integrase core domain; Region: rve; pfam00665 391616006496 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616006497 Sel1-like repeats; Region: SEL1; smart00671 391616006498 Sel1-like repeats; Region: SEL1; smart00671 391616006499 Sel1 repeat; Region: Sel1; pfam08238 391616006500 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006501 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006502 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006504 Transposase; Region: HTH_Tnp_1; cl17663 391616006505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616006506 putative transposase OrfB; Reviewed; Region: PHA02517 391616006507 HTH-like domain; Region: HTH_21; pfam13276 391616006508 Integrase core domain; Region: rve; pfam00665 391616006509 Integrase core domain; Region: rve_3; cl15866 391616006510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616006511 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616006512 active site 391616006513 catalytic tetrad [active] 391616006514 EamA-like transporter family; Region: EamA; pfam00892 391616006515 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616006516 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391616006517 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391616006518 H-NS histone family; Region: Histone_HNS; pfam00816 391616006519 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616006520 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391616006521 putative acyl-acceptor binding pocket; other site 391616006522 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391616006523 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391616006524 active site 391616006525 DNA binding site [nucleotide binding] 391616006526 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391616006527 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391616006528 Catalytic site [active] 391616006529 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 391616006530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616006531 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616006532 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616006533 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616006534 Integrase core domain; Region: rve; pfam00665 391616006535 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 391616006536 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 391616006537 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 391616006538 oxidase reductase; Provisional; Region: PTZ00273 391616006539 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 391616006540 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 391616006541 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616006542 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616006543 Integrase core domain; Region: rve; pfam00665 391616006544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616006545 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391616006546 active site 391616006547 Int/Topo IB signature motif; other site 391616006548 DNA binding site [nucleotide binding] 391616006549 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 391616006550 Imelysin; Region: Peptidase_M75; pfam09375 391616006551 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 391616006552 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 391616006553 Imelysin; Region: Peptidase_M75; cl09159 391616006554 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616006555 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006556 Helix-turn-helix domain; Region: HTH_17; pfam12728 391616006557 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616006558 active site 391616006559 Int/Topo IB signature motif; other site 391616006560 catalytic residues [active] 391616006561 DNA binding site [nucleotide binding] 391616006562 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 391616006563 Ligand Binding Site [chemical binding]; other site 391616006564 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 391616006565 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391616006566 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 391616006567 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006568 MULE transposase domain; Region: MULE; pfam10551 391616006569 Putative phosphatase (DUF442); Region: DUF442; cl17385 391616006570 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 391616006571 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391616006572 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 391616006573 Na binding site [ion binding]; other site 391616006574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616006575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616006576 dimer interface [polypeptide binding]; other site 391616006577 phosphorylation site [posttranslational modification] 391616006578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616006579 ATP binding site [chemical binding]; other site 391616006580 Mg2+ binding site [ion binding]; other site 391616006581 G-X-G motif; other site 391616006582 Response regulator receiver domain; Region: Response_reg; pfam00072 391616006583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616006584 active site 391616006585 phosphorylation site [posttranslational modification] 391616006586 intermolecular recognition site; other site 391616006587 dimerization interface [polypeptide binding]; other site 391616006588 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616006589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616006590 non-specific DNA binding site [nucleotide binding]; other site 391616006591 salt bridge; other site 391616006592 sequence-specific DNA binding site [nucleotide binding]; other site 391616006593 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391616006594 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391616006595 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391616006596 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391616006597 putative ligand binding site [chemical binding]; other site 391616006598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616006599 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616006600 TM-ABC transporter signature motif; other site 391616006601 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616006602 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616006603 TM-ABC transporter signature motif; other site 391616006604 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391616006605 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616006606 Walker A/P-loop; other site 391616006607 ATP binding site [chemical binding]; other site 391616006608 Q-loop/lid; other site 391616006609 ABC transporter signature motif; other site 391616006610 Walker B; other site 391616006611 D-loop; other site 391616006612 H-loop/switch region; other site 391616006613 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391616006614 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616006615 Walker A/P-loop; other site 391616006616 ATP binding site [chemical binding]; other site 391616006617 Q-loop/lid; other site 391616006618 ABC transporter signature motif; other site 391616006619 Walker B; other site 391616006620 D-loop; other site 391616006621 H-loop/switch region; other site 391616006622 acetyl-CoA synthetase; Provisional; Region: PRK00174 391616006623 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391616006624 active site 391616006625 CoA binding site [chemical binding]; other site 391616006626 acyl-activating enzyme (AAE) consensus motif; other site 391616006627 AMP binding site [chemical binding]; other site 391616006628 acetate binding site [chemical binding]; other site 391616006629 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 391616006630 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391616006631 carboxyltransferase (CT) interaction site; other site 391616006632 biotinylation site [posttranslational modification]; other site 391616006633 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391616006634 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616006635 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616006636 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391616006637 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006639 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006640 Homeodomain-like domain; Region: HTH_32; pfam13565 391616006641 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006642 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 391616006643 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 391616006644 mce related protein; Region: MCE; pfam02470 391616006645 NADH dehydrogenase; Validated; Region: PRK08183 391616006646 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 391616006647 homotrimer interaction site [polypeptide binding]; other site 391616006648 putative active site [active] 391616006649 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391616006650 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391616006651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616006652 Walker A motif; other site 391616006653 ATP binding site [chemical binding]; other site 391616006654 Walker B motif; other site 391616006655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391616006656 Clp protease; Region: CLP_protease; pfam00574 391616006657 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391616006658 oligomer interface [polypeptide binding]; other site 391616006659 active site residues [active] 391616006660 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391616006661 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616006662 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616006663 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 391616006664 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616006665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006666 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616006667 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616006668 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006669 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006670 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391616006671 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 391616006672 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616006673 FeS/SAM binding site; other site 391616006674 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391616006675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616006676 S-adenosylmethionine binding site [chemical binding]; other site 391616006677 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391616006678 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391616006679 metal binding site [ion binding]; metal-binding site 391616006680 putative dimer interface [polypeptide binding]; other site 391616006681 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616006682 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391616006683 acetylornithine deacetylase; Provisional; Region: PRK07522 391616006684 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391616006685 metal binding site [ion binding]; metal-binding site 391616006686 putative dimer interface [polypeptide binding]; other site 391616006687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391616006688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616006689 Walker A/P-loop; other site 391616006690 ATP binding site [chemical binding]; other site 391616006691 Q-loop/lid; other site 391616006692 ABC transporter signature motif; other site 391616006693 Walker B; other site 391616006694 D-loop; other site 391616006695 H-loop/switch region; other site 391616006696 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391616006697 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 391616006698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616006699 Walker A/P-loop; other site 391616006700 ATP binding site [chemical binding]; other site 391616006701 Q-loop/lid; other site 391616006702 ABC transporter signature motif; other site 391616006703 Walker B; other site 391616006704 D-loop; other site 391616006705 H-loop/switch region; other site 391616006706 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391616006707 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391616006708 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 391616006709 peptide binding site [polypeptide binding]; other site 391616006710 dimer interface [polypeptide binding]; other site 391616006711 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391616006712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616006713 dimer interface [polypeptide binding]; other site 391616006714 conserved gate region; other site 391616006715 putative PBP binding loops; other site 391616006716 ABC-ATPase subunit interface; other site 391616006717 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391616006718 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391616006719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616006720 dimer interface [polypeptide binding]; other site 391616006721 conserved gate region; other site 391616006722 putative PBP binding loops; other site 391616006723 ABC-ATPase subunit interface; other site 391616006724 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 391616006725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 391616006726 dimer interface [polypeptide binding]; other site 391616006727 active site 391616006728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391616006729 catalytic residues [active] 391616006730 substrate binding site [chemical binding]; other site 391616006731 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391616006732 pseudouridine synthase; Region: TIGR00093 391616006733 active site 391616006734 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 391616006735 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 391616006736 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 391616006737 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 391616006738 ligand binding site [chemical binding]; other site 391616006739 homodimer interface [polypeptide binding]; other site 391616006740 NAD(P) binding site [chemical binding]; other site 391616006741 trimer interface B [polypeptide binding]; other site 391616006742 trimer interface A [polypeptide binding]; other site 391616006743 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391616006744 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006745 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006746 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006748 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006749 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391616006750 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391616006751 Phospholipid methyltransferase; Region: PEMT; cl17370 391616006752 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616006753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616006754 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006755 Homeodomain-like domain; Region: HTH_32; pfam13565 391616006756 Winged helix-turn helix; Region: HTH_33; pfam13592 391616006757 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006758 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006759 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 391616006760 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391616006761 catalytic triad [active] 391616006762 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 391616006763 malate synthase G; Provisional; Region: PRK02999 391616006764 active site 391616006765 aminopeptidase N; Provisional; Region: pepN; PRK14015 391616006766 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 391616006767 Zn binding site [ion binding]; other site 391616006768 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616006769 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616006770 catalytic residue [active] 391616006771 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391616006772 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391616006773 GatB domain; Region: GatB_Yqey; smart00845 391616006774 ribonuclease E; Reviewed; Region: rne; PRK10811 391616006775 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391616006776 HSP70 interaction site [polypeptide binding]; other site 391616006777 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 391616006778 SelR domain; Region: SelR; pfam01641 391616006779 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391616006780 Fasciclin domain; Region: Fasciclin; pfam02469 391616006781 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 391616006782 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 391616006783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391616006784 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 391616006785 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391616006786 metal ion-dependent adhesion site (MIDAS); other site 391616006787 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616006788 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616006789 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 391616006790 active site 391616006791 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391616006792 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391616006793 FAD binding domain; Region: FAD_binding_4; pfam01565 391616006794 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391616006795 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391616006796 Walker A/P-loop; other site 391616006797 ATP binding site [chemical binding]; other site 391616006798 Q-loop/lid; other site 391616006799 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391616006800 ABC transporter signature motif; other site 391616006801 Walker B; other site 391616006802 D-loop; other site 391616006803 H-loop/switch region; other site 391616006804 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 391616006805 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 391616006806 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 391616006807 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 391616006808 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 391616006809 nucleotide binding site [chemical binding]; other site 391616006810 SulA interaction site; other site 391616006811 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 391616006812 Cell division protein FtsA; Region: FtsA; smart00842 391616006813 Cell division protein FtsA; Region: FtsA; pfam14450 391616006814 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391616006815 Cell division protein FtsQ; Region: FtsQ; pfam03799 391616006816 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391616006817 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391616006818 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616006819 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 391616006820 FAD binding domain; Region: FAD_binding_4; pfam01565 391616006821 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391616006822 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391616006823 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391616006824 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616006825 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391616006826 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391616006827 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391616006828 active site 391616006829 homodimer interface [polypeptide binding]; other site 391616006830 cell division protein FtsW; Region: ftsW; TIGR02614 391616006831 Predicted flavoproteins [General function prediction only]; Region: COG2081 391616006832 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 391616006833 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 391616006834 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616006835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616006836 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616006837 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 391616006838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616006839 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616006840 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616006841 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616006842 substrate binding pocket [chemical binding]; other site 391616006843 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391616006844 membrane-bound complex binding site; other site 391616006845 hinge residues; other site 391616006846 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616006847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616006848 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616006849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 391616006850 tetramer interface [polypeptide binding]; other site 391616006851 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 391616006852 active site 391616006853 Mg2+/Mn2+ binding site [ion binding]; other site 391616006854 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391616006855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616006856 DNA-binding site [nucleotide binding]; DNA binding site 391616006857 UTRA domain; Region: UTRA; pfam07702 391616006858 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 391616006859 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391616006860 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 391616006861 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391616006862 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391616006863 substrate binding site [chemical binding]; other site 391616006864 ligand binding site [chemical binding]; other site 391616006865 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391616006866 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391616006867 substrate binding site [chemical binding]; other site 391616006868 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391616006869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616006870 FAD binding site [chemical binding]; other site 391616006871 substrate binding pocket [chemical binding]; other site 391616006872 catalytic base [active] 391616006873 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391616006874 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391616006875 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 391616006876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616006877 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391616006878 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391616006879 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 391616006880 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391616006881 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391616006882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616006883 dimer interface [polypeptide binding]; other site 391616006884 conserved gate region; other site 391616006885 putative PBP binding loops; other site 391616006886 ABC-ATPase subunit interface; other site 391616006887 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 391616006888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616006889 Walker A/P-loop; other site 391616006890 ATP binding site [chemical binding]; other site 391616006891 Q-loop/lid; other site 391616006892 ABC transporter signature motif; other site 391616006893 Walker B; other site 391616006894 D-loop; other site 391616006895 H-loop/switch region; other site 391616006896 Integrase core domain; Region: rve; pfam00665 391616006897 Integrase core domain; Region: rve_3; pfam13683 391616006898 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006899 MULE transposase domain; Region: MULE; pfam10551 391616006900 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616006901 MULE transposase domain; Region: MULE; pfam10551 391616006902 Winged helix-turn helix; Region: HTH_29; pfam13551 391616006903 Homeodomain-like domain; Region: HTH_32; pfam13565 391616006904 Integrase core domain; Region: rve; pfam00665 391616006905 Integrase core domain; Region: rve_3; pfam13683 391616006906 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 391616006907 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391616006908 active site 391616006909 Int/Topo IB signature motif; other site 391616006910 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 391616006911 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 391616006912 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391616006913 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 391616006914 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391616006915 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391616006916 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391616006917 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616006918 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616006919 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616006920 active site 391616006921 DNA binding site [nucleotide binding] 391616006922 Int/Topo IB signature motif; other site 391616006923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616006924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616006925 putative substrate translocation pore; other site 391616006926 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 391616006927 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391616006928 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 391616006929 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 391616006930 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 391616006931 N- and C-terminal domain interface [polypeptide binding]; other site 391616006932 active site 391616006933 MgATP binding site [chemical binding]; other site 391616006934 catalytic site [active] 391616006935 metal binding site [ion binding]; metal-binding site 391616006936 carbohydrate binding site [chemical binding]; other site 391616006937 putative homodimer interface [polypeptide binding]; other site 391616006938 classical (c) SDRs; Region: SDR_c; cd05233 391616006939 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 391616006940 NAD(P) binding site [chemical binding]; other site 391616006941 active site 391616006942 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391616006943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616006944 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616006945 TM-ABC transporter signature motif; other site 391616006946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616006947 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 391616006948 Walker A/P-loop; other site 391616006949 ATP binding site [chemical binding]; other site 391616006950 Q-loop/lid; other site 391616006951 ABC transporter signature motif; other site 391616006952 Walker B; other site 391616006953 D-loop; other site 391616006954 H-loop/switch region; other site 391616006955 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391616006956 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391616006957 putative ligand binding site [chemical binding]; other site 391616006958 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616006959 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616006960 DNA binding site [nucleotide binding] 391616006961 domain linker motif; other site 391616006962 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616006963 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391616006964 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616006965 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616006966 active site 391616006967 Int/Topo IB signature motif; other site 391616006968 catalytic residues [active] 391616006969 DNA binding site [nucleotide binding] 391616006970 multiple promoter invertase; Provisional; Region: mpi; PRK13413 391616006971 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616006972 catalytic residues [active] 391616006973 catalytic nucleophile [active] 391616006974 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616006975 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616006976 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616006977 Synaptic Site I dimer interface [polypeptide binding]; other site 391616006978 DNA binding site [nucleotide binding] 391616006979 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 391616006980 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 391616006981 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 391616006982 Sporulation related domain; Region: SPOR; pfam05036 391616006983 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391616006984 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391616006985 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 391616006986 thymidylate kinase; Validated; Region: tmk; PRK00698 391616006987 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 391616006988 TMP-binding site; other site 391616006989 ATP-binding site [chemical binding]; other site 391616006990 DNA polymerase III subunit delta'; Validated; Region: PRK07471 391616006991 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391616006992 active site 391616006993 DNA polymerase III subunit delta'; Validated; Region: PRK08485 391616006994 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391616006995 active site 391616006996 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 391616006997 putative hydrolase; Provisional; Region: PRK02113 391616006998 Predicted permeases [General function prediction only]; Region: COG0679 391616006999 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 391616007000 ArsC family; Region: ArsC; pfam03960 391616007001 catalytic residue [active] 391616007002 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007003 Integrase core domain; Region: rve; pfam00665 391616007004 Integrase core domain; Region: rve_3; pfam13683 391616007005 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007006 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007007 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007008 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007009 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391616007010 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391616007011 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391616007012 active site 391616007013 dimer interface [polypeptide binding]; other site 391616007014 effector binding site; other site 391616007015 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391616007016 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391616007017 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391616007018 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391616007019 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391616007020 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391616007021 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616007022 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616007023 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616007024 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616007025 Transcriptional activator [Transcription]; Region: ChrR; COG3806 391616007026 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391616007027 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391616007028 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 391616007029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616007030 active site 391616007031 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007032 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007033 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007034 Homeodomain-like domain; Region: HTH_32; pfam13565 391616007035 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007036 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391616007037 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391616007038 substrate binding site [chemical binding]; other site 391616007039 catalytic Zn binding site [ion binding]; other site 391616007040 NAD binding site [chemical binding]; other site 391616007041 structural Zn binding site [ion binding]; other site 391616007042 dimer interface [polypeptide binding]; other site 391616007043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616007044 Transposase; Region: HTH_Tnp_1; pfam01527 391616007045 HTH-like domain; Region: HTH_21; pfam13276 391616007046 Integrase core domain; Region: rve; pfam00665 391616007047 Integrase core domain; Region: rve_2; pfam13333 391616007048 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 391616007049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007050 dimer interface [polypeptide binding]; other site 391616007051 conserved gate region; other site 391616007052 putative PBP binding loops; other site 391616007053 ABC-ATPase subunit interface; other site 391616007054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007055 dimer interface [polypeptide binding]; other site 391616007056 conserved gate region; other site 391616007057 ABC-ATPase subunit interface; other site 391616007058 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391616007059 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391616007060 Walker A/P-loop; other site 391616007061 ATP binding site [chemical binding]; other site 391616007062 Q-loop/lid; other site 391616007063 ABC transporter signature motif; other site 391616007064 Walker B; other site 391616007065 D-loop; other site 391616007066 H-loop/switch region; other site 391616007067 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391616007068 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391616007069 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391616007070 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391616007071 conserved cys residue [active] 391616007072 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391616007073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616007074 non-specific DNA binding site [nucleotide binding]; other site 391616007075 salt bridge; other site 391616007076 sequence-specific DNA binding site [nucleotide binding]; other site 391616007077 Cupin domain; Region: Cupin_2; pfam07883 391616007078 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391616007079 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391616007080 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391616007081 FMN-binding pocket [chemical binding]; other site 391616007082 flavin binding motif; other site 391616007083 phosphate binding motif [ion binding]; other site 391616007084 beta-alpha-beta structure motif; other site 391616007085 NAD binding pocket [chemical binding]; other site 391616007086 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616007087 catalytic loop [active] 391616007088 iron binding site [ion binding]; other site 391616007089 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616007090 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616007091 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 391616007092 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 391616007093 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391616007094 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 391616007095 active site 391616007096 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 391616007097 domain_subunit interface; other site 391616007098 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391616007099 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 391616007100 active site 391616007101 FMN binding site [chemical binding]; other site 391616007102 substrate binding site [chemical binding]; other site 391616007103 3Fe-4S cluster binding site [ion binding]; other site 391616007104 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 391616007105 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391616007106 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391616007107 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391616007108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616007109 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391616007110 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616007111 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616007112 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616007113 EamA-like transporter family; Region: EamA; cl17759 391616007114 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 391616007115 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391616007116 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391616007117 homodimer interface [polypeptide binding]; other site 391616007118 NADP binding site [chemical binding]; other site 391616007119 substrate binding site [chemical binding]; other site 391616007120 Integrase core domain; Region: rve; pfam00665 391616007121 Predicted dehydrogenase [General function prediction only]; Region: COG0579 391616007122 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616007123 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 391616007124 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007126 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007127 Homeodomain-like domain; Region: HTH_32; pfam13565 391616007128 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007129 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391616007130 binding surface 391616007131 TPR motif; other site 391616007132 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 391616007133 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616007134 EamA-like transporter family; Region: EamA; pfam00892 391616007135 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 391616007136 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 391616007137 active site 391616007138 substrate binding site [chemical binding]; other site 391616007139 metal binding site [ion binding]; metal-binding site 391616007140 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391616007141 dihydropteroate synthase; Region: DHPS; TIGR01496 391616007142 substrate binding pocket [chemical binding]; other site 391616007143 dimer interface [polypeptide binding]; other site 391616007144 inhibitor binding site; inhibition site 391616007145 Dihydroneopterin aldolase; Region: FolB; smart00905 391616007146 active site 391616007147 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 391616007148 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 391616007149 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391616007150 pyruvate phosphate dikinase; Provisional; Region: PRK09279 391616007151 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391616007152 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391616007153 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 391616007154 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 391616007155 dimer interface [polypeptide binding]; other site 391616007156 motif 1; other site 391616007157 active site 391616007158 motif 2; other site 391616007159 motif 3; other site 391616007160 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391616007161 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391616007162 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391616007163 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616007164 hypothetical protein; Provisional; Region: PRK07524 391616007165 PYR/PP interface [polypeptide binding]; other site 391616007166 dimer interface [polypeptide binding]; other site 391616007167 TPP binding site [chemical binding]; other site 391616007168 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391616007169 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391616007170 TPP-binding site [chemical binding]; other site 391616007171 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391616007172 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391616007173 putative GTP cyclohydrolase; Provisional; Region: PRK13674 391616007174 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 391616007175 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616007176 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616007177 catalytic residue [active] 391616007178 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 391616007179 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391616007180 C-terminal domain interface [polypeptide binding]; other site 391616007181 GSH binding site (G-site) [chemical binding]; other site 391616007182 dimer interface [polypeptide binding]; other site 391616007183 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616007184 N-terminal domain interface [polypeptide binding]; other site 391616007185 dimer interface [polypeptide binding]; other site 391616007186 substrate binding pocket (H-site) [chemical binding]; other site 391616007187 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616007188 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616007189 PilZ domain; Region: PilZ; cl01260 391616007190 Intracellular septation protein A; Region: IspA; pfam04279 391616007191 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391616007192 EamA-like transporter family; Region: EamA; pfam00892 391616007193 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 391616007194 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391616007195 P loop; other site 391616007196 GTP binding site [chemical binding]; other site 391616007197 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 391616007198 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391616007199 Di-iron ligands [ion binding]; other site 391616007200 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391616007201 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 391616007202 generic binding surface II; other site 391616007203 generic binding surface I; other site 391616007204 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391616007205 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391616007206 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 391616007207 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391616007208 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 391616007209 Ferredoxin [Energy production and conversion]; Region: COG1146 391616007210 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 391616007211 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391616007212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616007213 RNA binding surface [nucleotide binding]; other site 391616007214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 391616007215 ATP binding site [chemical binding]; other site 391616007216 putative Mg++ binding site [ion binding]; other site 391616007217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616007218 nucleotide binding region [chemical binding]; other site 391616007219 ATP-binding site [chemical binding]; other site 391616007220 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616007221 binding surface 391616007222 TPR repeat; Region: TPR_11; pfam13414 391616007223 TPR motif; other site 391616007224 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391616007225 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391616007226 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 391616007227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391616007228 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 391616007229 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 391616007230 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391616007231 ATP-dependent DNA ligase; Validated; Region: PRK09247 391616007232 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 391616007233 active site 391616007234 DNA binding site [nucleotide binding] 391616007235 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 391616007236 DNA binding site [nucleotide binding] 391616007237 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 391616007238 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 391616007239 active site 391616007240 Zn binding site [ion binding]; other site 391616007241 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616007242 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007243 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007244 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007246 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 391616007247 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391616007248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616007249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616007250 DNA binding residues [nucleotide binding] 391616007251 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 391616007252 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616007253 RNA binding surface [nucleotide binding]; other site 391616007254 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391616007255 active site 391616007256 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007257 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616007258 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616007259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391616007260 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391616007261 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391616007262 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 391616007263 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 391616007264 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391616007265 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 391616007266 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616007267 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 391616007268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616007269 dimerization interface [polypeptide binding]; other site 391616007270 putative DNA binding site [nucleotide binding]; other site 391616007271 putative Zn2+ binding site [ion binding]; other site 391616007272 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391616007273 putative hydrophobic ligand binding site [chemical binding]; other site 391616007274 transcription antitermination factor NusB; Region: nusB; TIGR01951 391616007275 putative RNA binding site [nucleotide binding]; other site 391616007276 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 391616007277 homopentamer interface [polypeptide binding]; other site 391616007278 active site 391616007279 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 391616007280 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 391616007281 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 391616007282 dimerization interface [polypeptide binding]; other site 391616007283 active site 391616007284 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 391616007285 Lumazine binding domain; Region: Lum_binding; pfam00677 391616007286 Lumazine binding domain; Region: Lum_binding; pfam00677 391616007287 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 391616007288 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 391616007289 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 391616007290 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391616007291 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 391616007292 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391616007293 catalytic motif [active] 391616007294 Zn binding site [ion binding]; other site 391616007295 RibD C-terminal domain; Region: RibD_C; cl17279 391616007296 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391616007297 ATP cone domain; Region: ATP-cone; pfam03477 391616007298 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 391616007299 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391616007300 metal binding site [ion binding]; metal-binding site 391616007301 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 391616007302 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 391616007303 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 391616007304 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391616007305 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 391616007306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616007307 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391616007308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616007309 DNA binding residues [nucleotide binding] 391616007310 DNA primase; Validated; Region: dnaG; PRK05667 391616007311 CHC2 zinc finger; Region: zf-CHC2; cl17510 391616007312 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391616007313 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391616007314 active site 391616007315 metal binding site [ion binding]; metal-binding site 391616007316 interdomain interaction site; other site 391616007317 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391616007318 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616007319 Lysine efflux permease [General function prediction only]; Region: COG1279 391616007320 hypothetical protein; Validated; Region: PRK00110 391616007321 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007323 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007324 Homeodomain-like domain; Region: HTH_32; pfam13565 391616007325 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007326 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007327 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007328 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007329 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007330 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007331 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007332 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007334 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391616007335 catalytic triad [active] 391616007336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391616007337 transmembrane helices; other site 391616007338 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391616007339 TrkA-C domain; Region: TrkA_C; pfam02080 391616007340 TrkA-C domain; Region: TrkA_C; pfam02080 391616007341 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 391616007342 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616007343 EamA-like transporter family; Region: EamA; pfam00892 391616007344 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 391616007345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616007346 putative active site [active] 391616007347 metal binding site [ion binding]; metal-binding site 391616007348 homodimer binding site [polypeptide binding]; other site 391616007349 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 391616007350 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 391616007351 MgtE intracellular N domain; Region: MgtE_N; smart00924 391616007352 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 391616007353 Divalent cation transporter; Region: MgtE; cl00786 391616007354 guanine deaminase; Provisional; Region: PRK09228 391616007355 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 391616007356 active site 391616007357 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391616007358 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 391616007359 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 391616007360 active site 391616007361 putative substrate binding pocket [chemical binding]; other site 391616007362 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616007363 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616007364 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616007365 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616007366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007367 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616007368 HTH-like domain; Region: HTH_21; pfam13276 391616007369 Integrase core domain; Region: rve; pfam00665 391616007370 Integrase core domain; Region: rve_2; pfam13333 391616007371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616007372 Transposase; Region: HTH_Tnp_1; pfam01527 391616007373 GTP-binding protein Der; Reviewed; Region: PRK00093 391616007374 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 391616007375 G1 box; other site 391616007376 GTP/Mg2+ binding site [chemical binding]; other site 391616007377 Switch I region; other site 391616007378 G2 box; other site 391616007379 Switch II region; other site 391616007380 G3 box; other site 391616007381 G4 box; other site 391616007382 G5 box; other site 391616007383 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 391616007384 G1 box; other site 391616007385 GTP/Mg2+ binding site [chemical binding]; other site 391616007386 Switch I region; other site 391616007387 G2 box; other site 391616007388 G3 box; other site 391616007389 Switch II region; other site 391616007390 G4 box; other site 391616007391 G5 box; other site 391616007392 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 391616007393 Trp docking motif [polypeptide binding]; other site 391616007394 active site 391616007395 PQQ-like domain; Region: PQQ_2; pfam13360 391616007396 PQQ-like domain; Region: PQQ_2; pfam13360 391616007397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649 391616007398 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 391616007399 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391616007400 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391616007401 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616007402 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391616007403 Protein export membrane protein; Region: SecD_SecF; cl14618 391616007404 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391616007405 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007406 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007407 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007408 Homeodomain-like domain; Region: HTH_32; pfam13565 391616007409 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007410 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391616007411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616007412 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391616007413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616007414 Walker A/P-loop; other site 391616007415 ATP binding site [chemical binding]; other site 391616007416 Q-loop/lid; other site 391616007417 ABC transporter signature motif; other site 391616007418 Walker B; other site 391616007419 D-loop; other site 391616007420 H-loop/switch region; other site 391616007421 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391616007422 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391616007423 metal ion-dependent adhesion site (MIDAS); other site 391616007424 MoxR-like ATPases [General function prediction only]; Region: COG0714 391616007425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616007426 Walker A motif; other site 391616007427 ATP binding site [chemical binding]; other site 391616007428 Walker B motif; other site 391616007429 arginine finger; other site 391616007430 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391616007431 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616007432 FAD binding site [chemical binding]; other site 391616007433 substrate binding pocket [chemical binding]; other site 391616007434 catalytic base [active] 391616007435 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007436 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007437 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007439 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 391616007440 active site 391616007441 substrate binding pocket [chemical binding]; other site 391616007442 dimer interface [polypeptide binding]; other site 391616007443 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616007444 active site 391616007445 replicative DNA helicase; Provisional; Region: PRK09165 391616007446 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391616007447 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391616007448 Walker A motif; other site 391616007449 ATP binding site [chemical binding]; other site 391616007450 Walker B motif; other site 391616007451 DNA binding loops [nucleotide binding] 391616007452 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 391616007453 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 391616007454 active site 391616007455 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391616007456 dimer interface [polypeptide binding]; other site 391616007457 substrate binding site [chemical binding]; other site 391616007458 catalytic residues [active] 391616007459 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391616007460 Permease; Region: Permease; pfam02405 391616007461 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391616007462 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 391616007463 Walker A/P-loop; other site 391616007464 ATP binding site [chemical binding]; other site 391616007465 Q-loop/lid; other site 391616007466 ABC transporter signature motif; other site 391616007467 Walker B; other site 391616007468 D-loop; other site 391616007469 H-loop/switch region; other site 391616007470 Integrase core domain; Region: rve; pfam00665 391616007471 Integrase core domain; Region: rve_3; pfam13683 391616007472 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616007473 Integrase core domain; Region: rve; pfam00665 391616007474 Paraquat-inducible protein A; Region: PqiA; pfam04403 391616007475 DNA repair protein RadA; Provisional; Region: PRK11823 391616007476 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 391616007477 Walker A motif/ATP binding site; other site 391616007478 ATP binding site [chemical binding]; other site 391616007479 Walker B motif; other site 391616007480 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391616007481 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 391616007482 Colicin V production protein; Region: Colicin_V; pfam02674 391616007483 amidophosphoribosyltransferase; Provisional; Region: PRK09123 391616007484 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391616007485 active site 391616007486 tetramer interface [polypeptide binding]; other site 391616007487 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616007488 active site 391616007489 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391616007490 classical (c) SDRs; Region: SDR_c; cd05233 391616007491 NAD(P) binding site [chemical binding]; other site 391616007492 active site 391616007493 Survival protein SurE; Region: SurE; cl00448 391616007494 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 391616007495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616007496 S-adenosylmethionine binding site [chemical binding]; other site 391616007497 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 391616007498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391616007499 Peptidase family M23; Region: Peptidase_M23; pfam01551 391616007500 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 391616007501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616007502 Walker A motif; other site 391616007503 ATP binding site [chemical binding]; other site 391616007504 Walker B motif; other site 391616007505 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 391616007506 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391616007507 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391616007508 HTH domain; Region: HTH_11; pfam08279 391616007509 WYL domain; Region: WYL; pfam13280 391616007510 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391616007511 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391616007512 Walker A/P-loop; other site 391616007513 ATP binding site [chemical binding]; other site 391616007514 Q-loop/lid; other site 391616007515 ABC transporter signature motif; other site 391616007516 Walker B; other site 391616007517 D-loop; other site 391616007518 H-loop/switch region; other site 391616007519 TOBE domain; Region: TOBE_2; pfam08402 391616007520 short chain dehydrogenase; Provisional; Region: PRK08339 391616007521 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 391616007522 putative NAD(P) binding site [chemical binding]; other site 391616007523 putative active site [active] 391616007524 Hint domain; Region: Hint_2; pfam13403 391616007525 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 391616007526 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 391616007527 G1 box; other site 391616007528 putative GEF interaction site [polypeptide binding]; other site 391616007529 GTP/Mg2+ binding site [chemical binding]; other site 391616007530 Switch I region; other site 391616007531 G2 box; other site 391616007532 G3 box; other site 391616007533 Switch II region; other site 391616007534 G4 box; other site 391616007535 G5 box; other site 391616007536 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 391616007537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616007538 helicase 45; Provisional; Region: PTZ00424 391616007539 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391616007540 ATP binding site [chemical binding]; other site 391616007541 Mg++ binding site [ion binding]; other site 391616007542 motif III; other site 391616007543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616007544 nucleotide binding region [chemical binding]; other site 391616007545 ATP-binding site [chemical binding]; other site 391616007546 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 391616007547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391616007548 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 391616007549 pantothenate kinase; Reviewed; Region: PRK13318 391616007550 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391616007551 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 391616007552 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391616007553 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391616007554 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391616007555 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391616007556 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391616007557 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 391616007558 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391616007559 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391616007560 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 391616007561 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391616007562 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391616007563 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 391616007564 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391616007565 4Fe-4S binding domain; Region: Fer4; pfam00037 391616007566 4Fe-4S binding domain; Region: Fer4; pfam00037 391616007567 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391616007568 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 391616007569 NADH dehydrogenase subunit G; Validated; Region: PRK09130 391616007570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616007571 catalytic loop [active] 391616007572 iron binding site [ion binding]; other site 391616007573 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391616007574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391616007575 molybdopterin cofactor binding site; other site 391616007576 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 391616007577 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 391616007578 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 391616007579 SLBB domain; Region: SLBB; pfam10531 391616007580 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391616007581 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391616007582 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 391616007583 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 391616007584 putative dimer interface [polypeptide binding]; other site 391616007585 [2Fe-2S] cluster binding site [ion binding]; other site 391616007586 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391616007587 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 391616007588 NADH dehydrogenase subunit D; Validated; Region: PRK06075 391616007589 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 391616007590 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 391616007591 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391616007592 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 391616007593 enoyl-CoA hydratase; Provisional; Region: PRK07468 391616007594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616007595 substrate binding site [chemical binding]; other site 391616007596 oxyanion hole (OAH) forming residues; other site 391616007597 trimer interface [polypeptide binding]; other site 391616007598 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 391616007599 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391616007600 active site 391616007601 catalytic residues [active] 391616007602 metal binding site [ion binding]; metal-binding site 391616007603 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391616007604 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616007605 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616007606 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 391616007607 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391616007608 carboxyltransferase (CT) interaction site; other site 391616007609 biotinylation site [posttranslational modification]; other site 391616007610 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391616007611 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391616007612 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 391616007613 substrate binding site [chemical binding]; other site 391616007614 oxyanion hole (OAH) forming residues; other site 391616007615 trimer interface [polypeptide binding]; other site 391616007616 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 391616007617 isovaleryl-CoA dehydrogenase; Region: PLN02519 391616007618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391616007619 active site 391616007620 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 391616007621 Catalytic site [active] 391616007622 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391616007623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616007624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616007625 catalytic residue [active] 391616007626 phosphoglycolate phosphatase; Provisional; Region: PRK13222 391616007627 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391616007628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616007629 motif II; other site 391616007630 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 391616007631 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391616007632 Substrate binding site; other site 391616007633 Mg++ binding site; other site 391616007634 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391616007635 active site 391616007636 substrate binding site [chemical binding]; other site 391616007637 CoA binding site [chemical binding]; other site 391616007638 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391616007639 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 391616007640 glutaminase active site [active] 391616007641 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391616007642 dimer interface [polypeptide binding]; other site 391616007643 active site 391616007644 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391616007645 dimer interface [polypeptide binding]; other site 391616007646 active site 391616007647 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 391616007648 A new structural DNA glycosylase; Region: AlkD_like; cd06561 391616007649 active site 391616007650 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 391616007651 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391616007652 active site 391616007653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616007654 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616007655 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616007656 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007657 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007658 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007659 Homeodomain-like domain; Region: HTH_32; pfam13565 391616007660 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007661 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616007662 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616007663 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616007664 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616007665 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616007666 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616007667 Integrase core domain; Region: rve; pfam00665 391616007668 HTH-like domain; Region: HTH_21; pfam13276 391616007669 Integrase core domain; Region: rve; pfam00665 391616007670 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 391616007671 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391616007672 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 391616007673 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616007674 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 391616007675 active site 391616007676 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 391616007677 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007678 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007679 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007681 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007682 MULE transposase domain; Region: MULE; pfam10551 391616007683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616007684 Transposase; Region: HTH_Tnp_1; pfam01527 391616007685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007686 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616007687 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007688 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616007689 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616007690 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616007691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616007692 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007693 MULE transposase domain; Region: MULE; pfam10551 391616007694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391616007695 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391616007696 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391616007697 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007698 MULE transposase domain; Region: MULE; pfam10551 391616007699 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007700 MULE transposase domain; Region: MULE; pfam10551 391616007701 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 391616007702 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 391616007703 VirB7 interaction site; other site 391616007704 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 391616007705 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 391616007706 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391616007707 Walker A motif; other site 391616007708 ATP binding site [chemical binding]; other site 391616007709 Walker B motif; other site 391616007710 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 391616007711 DNA topoisomerase III; Provisional; Region: PRK07726 391616007712 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 391616007713 active site 391616007714 interdomain interaction site; other site 391616007715 putative metal-binding site [ion binding]; other site 391616007716 nucleotide binding site [chemical binding]; other site 391616007717 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 391616007718 domain I; other site 391616007719 DNA binding groove [nucleotide binding] 391616007720 phosphate binding site [ion binding]; other site 391616007721 domain II; other site 391616007722 domain III; other site 391616007723 nucleotide binding site [chemical binding]; other site 391616007724 catalytic site [active] 391616007725 domain IV; other site 391616007726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616007727 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616007728 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616007729 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616007730 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616007731 active site 391616007732 DNA binding site [nucleotide binding] 391616007733 Int/Topo IB signature motif; other site 391616007734 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391616007735 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 391616007736 DAK2 domain; Region: Dak2; pfam02734 391616007737 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616007738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616007739 Walker A/P-loop; other site 391616007740 ATP binding site [chemical binding]; other site 391616007741 Q-loop/lid; other site 391616007742 ABC transporter signature motif; other site 391616007743 Walker B; other site 391616007744 D-loop; other site 391616007745 H-loop/switch region; other site 391616007746 TOBE domain; Region: TOBE_2; pfam08402 391616007747 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616007748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616007749 Walker A/P-loop; other site 391616007750 ATP binding site [chemical binding]; other site 391616007751 Q-loop/lid; other site 391616007752 ABC transporter signature motif; other site 391616007753 Walker B; other site 391616007754 D-loop; other site 391616007755 H-loop/switch region; other site 391616007756 TOBE domain; Region: TOBE_2; pfam08402 391616007757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007759 dimer interface [polypeptide binding]; other site 391616007760 conserved gate region; other site 391616007761 putative PBP binding loops; other site 391616007762 ABC-ATPase subunit interface; other site 391616007763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007764 dimer interface [polypeptide binding]; other site 391616007765 conserved gate region; other site 391616007766 ABC-ATPase subunit interface; other site 391616007767 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616007768 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616007769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616007770 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616007771 DNA binding site [nucleotide binding] 391616007772 domain linker motif; other site 391616007773 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391616007774 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616007775 putative ligand binding site [chemical binding]; other site 391616007776 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616007777 Putative transposase; Region: Y2_Tnp; pfam04986 391616007778 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616007779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616007780 active site 391616007781 DNA binding site [nucleotide binding] 391616007782 Int/Topo IB signature motif; other site 391616007783 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 391616007784 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 391616007785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616007786 Walker A motif; other site 391616007787 ATP binding site [chemical binding]; other site 391616007788 Walker B motif; other site 391616007789 Family description; Region: UvrD_C_2; pfam13538 391616007790 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 391616007791 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391616007792 Walker A motif; other site 391616007793 ATP binding site [chemical binding]; other site 391616007794 Walker B motif; other site 391616007795 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 391616007796 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 391616007797 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616007798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616007799 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616007800 Walker A motif; other site 391616007801 ATP binding site [chemical binding]; other site 391616007802 Walker B motif; other site 391616007803 arginine finger; other site 391616007804 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 391616007805 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391616007806 NAD binding site [chemical binding]; other site 391616007807 substrate binding site [chemical binding]; other site 391616007808 putative active site [active] 391616007809 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391616007810 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391616007811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616007812 catalytic residue [active] 391616007813 Alternative oxidase; Region: AOX; pfam01786 391616007814 dinuclear metal binding motif [ion binding]; other site 391616007815 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616007816 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616007817 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616007818 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 391616007819 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391616007820 Short chain fatty acid transporter; Region: SCFA_trans; cl17380 391616007821 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616007822 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616007823 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616007824 N-terminal domain interface [polypeptide binding]; other site 391616007825 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 391616007826 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391616007827 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616007828 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391616007829 Fasciclin domain; Region: Fasciclin; pfam02469 391616007830 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616007831 EamA-like transporter family; Region: EamA; pfam00892 391616007832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616007833 Integrase core domain; Region: rve; pfam00665 391616007834 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391616007835 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391616007836 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391616007837 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 391616007838 substrate binding site [chemical binding]; other site 391616007839 THF binding site; other site 391616007840 zinc-binding site [ion binding]; other site 391616007841 Cupin domain; Region: Cupin_2; pfam07883 391616007842 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616007843 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616007844 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616007845 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616007846 DNA binding site [nucleotide binding] 391616007847 domain linker motif; other site 391616007848 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391616007849 putative dimerization interface [polypeptide binding]; other site 391616007850 putative ligand binding site [chemical binding]; other site 391616007851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616007852 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391616007853 NAD(P) binding site [chemical binding]; other site 391616007854 active site 391616007855 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616007856 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616007857 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391616007858 histidinol dehydrogenase; Region: hisD; TIGR00069 391616007859 NAD binding site [chemical binding]; other site 391616007860 dimerization interface [polypeptide binding]; other site 391616007861 product binding site; other site 391616007862 substrate binding site [chemical binding]; other site 391616007863 zinc binding site [ion binding]; other site 391616007864 catalytic residues [active] 391616007865 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616007866 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616007867 Walker A/P-loop; other site 391616007868 ATP binding site [chemical binding]; other site 391616007869 Q-loop/lid; other site 391616007870 ABC transporter signature motif; other site 391616007871 Walker B; other site 391616007872 D-loop; other site 391616007873 H-loop/switch region; other site 391616007874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616007875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616007876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007877 dimer interface [polypeptide binding]; other site 391616007878 ABC-ATPase subunit interface; other site 391616007879 putative PBP binding loops; other site 391616007880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616007881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616007882 dimer interface [polypeptide binding]; other site 391616007883 conserved gate region; other site 391616007884 putative PBP binding loops; other site 391616007885 ABC-ATPase subunit interface; other site 391616007886 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616007887 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616007888 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007889 MULE transposase domain; Region: MULE; pfam10551 391616007890 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 391616007891 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391616007892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616007893 motif II; other site 391616007894 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 391616007895 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 391616007896 HTH-like domain; Region: HTH_21; pfam13276 391616007897 Integrase core domain; Region: rve; pfam00665 391616007898 Integrase core domain; Region: rve_3; pfam13683 391616007899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616007900 Transposase; Region: HTH_Tnp_1; pfam01527 391616007901 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616007902 active site 391616007903 catalytic residues [active] 391616007904 DNA binding site [nucleotide binding] 391616007905 Int/Topo IB signature motif; other site 391616007906 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007907 Integrase core domain; Region: rve; pfam00665 391616007908 Integrase core domain; Region: rve_3; pfam13683 391616007909 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007910 MULE transposase domain; Region: MULE; pfam10551 391616007911 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616007912 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616007913 Integrase core domain; Region: rve; pfam00665 391616007914 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391616007915 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391616007916 active site 391616007917 DNA binding site [nucleotide binding] 391616007918 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391616007919 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391616007920 Catalytic site [active] 391616007921 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 391616007922 YaeQ protein; Region: YaeQ; pfam07152 391616007923 Transposase; Region: HTH_Tnp_1; pfam01527 391616007924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616007925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007926 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616007927 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616007928 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616007929 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616007930 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616007931 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616007932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616007933 active site 391616007934 DNA binding site [nucleotide binding] 391616007935 Int/Topo IB signature motif; other site 391616007936 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 391616007937 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 391616007938 N- and C-terminal domain interface [polypeptide binding]; other site 391616007939 active site 391616007940 MgATP binding site [chemical binding]; other site 391616007941 catalytic site [active] 391616007942 metal binding site [ion binding]; metal-binding site 391616007943 carbohydrate binding site [chemical binding]; other site 391616007944 putative homodimer interface [polypeptide binding]; other site 391616007945 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391616007946 classical (c) SDRs; Region: SDR_c; cd05233 391616007947 NAD(P) binding site [chemical binding]; other site 391616007948 active site 391616007949 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 391616007950 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616007951 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616007952 TM-ABC transporter signature motif; other site 391616007953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616007954 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 391616007955 Walker A/P-loop; other site 391616007956 ATP binding site [chemical binding]; other site 391616007957 Q-loop/lid; other site 391616007958 ABC transporter signature motif; other site 391616007959 Walker B; other site 391616007960 D-loop; other site 391616007961 H-loop/switch region; other site 391616007962 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 391616007963 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391616007964 putative ligand binding site [chemical binding]; other site 391616007965 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616007966 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616007967 DNA binding site [nucleotide binding] 391616007968 domain linker motif; other site 391616007969 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616007970 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 391616007971 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616007972 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391616007973 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 391616007974 putative NAD(P) binding site [chemical binding]; other site 391616007975 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616007976 MULE transposase domain; Region: MULE; pfam10551 391616007977 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 391616007978 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616007979 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616007980 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391616007981 dimerization interface [polypeptide binding]; other site 391616007982 Winged helix-turn helix; Region: HTH_29; pfam13551 391616007983 Winged helix-turn helix; Region: HTH_33; pfam13592 391616007984 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616007985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616007986 GTP-binding protein YchF; Reviewed; Region: PRK09601 391616007987 YchF GTPase; Region: YchF; cd01900 391616007988 G1 box; other site 391616007989 GTP/Mg2+ binding site [chemical binding]; other site 391616007990 Switch I region; other site 391616007991 G2 box; other site 391616007992 Switch II region; other site 391616007993 G3 box; other site 391616007994 G4 box; other site 391616007995 G5 box; other site 391616007996 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391616007997 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 391616007998 substrate binding site [chemical binding]; other site 391616007999 active site 391616008000 catalytic residues [active] 391616008001 heterodimer interface [polypeptide binding]; other site 391616008002 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391616008003 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391616008004 phosphate binding site [ion binding]; other site 391616008005 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 391616008006 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 391616008007 5S rRNA interface [nucleotide binding]; other site 391616008008 CTC domain interface [polypeptide binding]; other site 391616008009 L16 interface [polypeptide binding]; other site 391616008010 GAF domain; Region: GAF; pfam01590 391616008011 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391616008012 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616008013 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391616008014 putative active site [active] 391616008015 catalytic residue [active] 391616008016 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 391616008017 Beta-lactamase; Region: Beta-lactamase; pfam00144 391616008018 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391616008019 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 391616008020 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 391616008021 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391616008022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008023 catalytic residue [active] 391616008024 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 391616008025 active site 391616008026 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391616008027 IHF dimer interface [polypeptide binding]; other site 391616008028 IHF - DNA interface [nucleotide binding]; other site 391616008029 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 391616008030 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391616008031 RNA binding site [nucleotide binding]; other site 391616008032 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391616008033 RNA binding site [nucleotide binding]; other site 391616008034 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 391616008035 RNA binding site [nucleotide binding]; other site 391616008036 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391616008037 RNA binding site [nucleotide binding]; other site 391616008038 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391616008039 RNA binding site [nucleotide binding]; other site 391616008040 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 391616008041 RNA binding site [nucleotide binding]; other site 391616008042 Uncharacterized conserved protein [Function unknown]; Region: COG2128 391616008043 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 391616008044 dimer interface [polypeptide binding]; other site 391616008045 FMN binding site [chemical binding]; other site 391616008046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 391616008047 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 391616008048 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616008049 active site residue [active] 391616008050 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391616008051 catalytic core [active] 391616008052 cytidylate kinase; Provisional; Region: cmk; PRK00023 391616008053 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391616008054 CMP-binding site; other site 391616008055 The sites determining sugar specificity; other site 391616008056 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391616008057 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391616008058 hinge; other site 391616008059 active site 391616008060 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 391616008061 Predicted membrane protein [Function unknown]; Region: COG2259 391616008062 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391616008063 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391616008064 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391616008065 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391616008066 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 391616008067 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391616008068 putative active site [active] 391616008069 catalytic triad [active] 391616008070 putative dimer interface [polypeptide binding]; other site 391616008071 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 391616008072 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391616008073 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391616008074 Transporter associated domain; Region: CorC_HlyC; smart01091 391616008075 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 391616008076 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 391616008077 PhoH-like protein; Region: PhoH; pfam02562 391616008078 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616008079 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616008080 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008081 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008082 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008084 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008085 Integrase core domain; Region: rve; pfam00665 391616008086 Integrase core domain; Region: rve_3; pfam13683 391616008087 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 391616008088 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391616008089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616008090 FeS/SAM binding site; other site 391616008091 TRAM domain; Region: TRAM; pfam01938 391616008092 Predicted P-loop ATPase/GTPase [General function prediction only]; Region: COG4028 391616008093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616008094 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616008095 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391616008096 metal binding site 2 [ion binding]; metal-binding site 391616008097 putative DNA binding helix; other site 391616008098 metal binding site 1 [ion binding]; metal-binding site 391616008099 dimer interface [polypeptide binding]; other site 391616008100 structural Zn2+ binding site [ion binding]; other site 391616008101 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 391616008102 active site 1 [active] 391616008103 dimer interface [polypeptide binding]; other site 391616008104 active site 2 [active] 391616008105 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008106 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008107 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008108 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008109 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 391616008110 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391616008111 dimer interface [polypeptide binding]; other site 391616008112 active site 391616008113 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 391616008114 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391616008115 NAD binding site [chemical binding]; other site 391616008116 homotetramer interface [polypeptide binding]; other site 391616008117 homodimer interface [polypeptide binding]; other site 391616008118 substrate binding site [chemical binding]; other site 391616008119 active site 391616008120 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 391616008121 Peptidase family M50; Region: Peptidase_M50; pfam02163 391616008122 active site 391616008123 putative substrate binding region [chemical binding]; other site 391616008124 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616008125 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616008126 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 391616008127 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391616008128 Domain of unknown function (DU1801); Region: DUF1801; cl17490 391616008129 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 391616008130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616008131 motif II; other site 391616008132 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616008133 serine racemase; Region: PLN02970 391616008134 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391616008135 tetramer interface [polypeptide binding]; other site 391616008136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008137 catalytic residue [active] 391616008138 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391616008139 putative phosphate binding site [ion binding]; other site 391616008140 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391616008141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616008142 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616008143 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 391616008144 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391616008145 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 391616008146 NAD binding site [chemical binding]; other site 391616008147 catalytic Zn binding site [ion binding]; other site 391616008148 substrate binding site [chemical binding]; other site 391616008149 structural Zn binding site [ion binding]; other site 391616008150 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391616008151 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391616008152 active site pocket [active] 391616008153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616008154 WHG domain; Region: WHG; pfam13305 391616008155 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 391616008156 yiaA/B two helix domain; Region: YiaAB; cl01759 391616008157 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391616008158 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391616008159 putative acyl-acceptor binding pocket; other site 391616008160 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 391616008161 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391616008162 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 391616008163 putative catalytic site [active] 391616008164 putative metal binding site [ion binding]; other site 391616008165 putative phosphate binding site [ion binding]; other site 391616008166 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 391616008167 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 391616008168 MOFRL family; Region: MOFRL; pfam05161 391616008169 Methyltransferase domain; Region: Methyltransf_24; pfam13578 391616008170 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008171 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008172 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008174 AAA domain; Region: AAA_22; pfam13401 391616008175 HTH-like domain; Region: HTH_21; pfam13276 391616008176 Integrase core domain; Region: rve; pfam00665 391616008177 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616008178 Integrase core domain; Region: rve_3; pfam13683 391616008179 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 391616008180 ManB is a bacterial phosphomannomutase (PMM) that catalyzes the conversion of mannose 6-phosphate to mannose-1-phosphate in the second of three steps in the GDP-mannose pathway, in which GDP-D-mannose is synthesized from fructose-6-phosphate. In...; Region: ManB; cd03088 391616008181 active site 391616008182 substrate binding site [chemical binding]; other site 391616008183 metal binding site [ion binding]; metal-binding site 391616008184 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391616008185 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 391616008186 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 391616008187 Substrate binding site; other site 391616008188 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 391616008189 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 391616008190 active site 391616008191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 391616008192 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 391616008193 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 391616008194 excinuclease ABC subunit B; Provisional; Region: PRK05298 391616008195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616008196 ATP binding site [chemical binding]; other site 391616008197 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616008198 nucleotide binding region [chemical binding]; other site 391616008199 ATP-binding site [chemical binding]; other site 391616008200 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391616008201 UvrB/uvrC motif; Region: UVR; pfam02151 391616008202 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616008203 MULE transposase domain; Region: MULE; pfam10551 391616008204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616008205 active site residue [active] 391616008206 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 391616008207 Uncharacterized conserved protein [Function unknown]; Region: COG1434 391616008208 putative active site [active] 391616008209 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 391616008210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616008211 active site 391616008212 nucleotide binding site [chemical binding]; other site 391616008213 HIGH motif; other site 391616008214 KMSKS motif; other site 391616008215 tellurite resistance protein terB; Region: terB; cd07176 391616008216 putative metal binding site [ion binding]; other site 391616008217 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 391616008218 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 391616008219 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 391616008220 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391616008221 active site 391616008222 (T/H)XGH motif; other site 391616008223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391616008224 PAS domain; Region: PAS_9; pfam13426 391616008225 putative active site [active] 391616008226 heme pocket [chemical binding]; other site 391616008227 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391616008228 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391616008229 metal binding site [ion binding]; metal-binding site 391616008230 active site 391616008231 I-site; other site 391616008232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616008233 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391616008234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616008235 Walker A/P-loop; other site 391616008236 ATP binding site [chemical binding]; other site 391616008237 Q-loop/lid; other site 391616008238 ABC transporter signature motif; other site 391616008239 Walker B; other site 391616008240 D-loop; other site 391616008241 H-loop/switch region; other site 391616008242 ABC transporter; Region: ABC_tran_2; pfam12848 391616008243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391616008244 Response regulator receiver domain; Region: Response_reg; pfam00072 391616008245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616008246 active site 391616008247 phosphorylation site [posttranslational modification] 391616008248 intermolecular recognition site; other site 391616008249 dimerization interface [polypeptide binding]; other site 391616008250 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 391616008251 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 391616008252 PhnA protein; Region: PhnA; pfam03831 391616008253 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391616008254 DNA-binding site [nucleotide binding]; DNA binding site 391616008255 RNA-binding motif; other site 391616008256 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 391616008257 active site 391616008258 catalytic triad [active] 391616008259 oxyanion hole [active] 391616008260 switch loop; other site 391616008261 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 391616008262 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391616008263 Walker A/P-loop; other site 391616008264 ATP binding site [chemical binding]; other site 391616008265 Q-loop/lid; other site 391616008266 ABC transporter signature motif; other site 391616008267 Walker B; other site 391616008268 D-loop; other site 391616008269 H-loop/switch region; other site 391616008270 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391616008271 FtsX-like permease family; Region: FtsX; pfam02687 391616008272 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616008273 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616008274 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616008275 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391616008276 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391616008277 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 391616008278 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391616008279 HIGH motif; other site 391616008280 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391616008281 active site 391616008282 KMSKS motif; other site 391616008283 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 391616008284 NAD synthetase; Provisional; Region: PRK13981 391616008285 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391616008286 multimer interface [polypeptide binding]; other site 391616008287 active site 391616008288 catalytic triad [active] 391616008289 protein interface 1 [polypeptide binding]; other site 391616008290 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 391616008291 homodimer interface [polypeptide binding]; other site 391616008292 NAD binding pocket [chemical binding]; other site 391616008293 ATP binding pocket [chemical binding]; other site 391616008294 Mg binding site [ion binding]; other site 391616008295 active-site loop [active] 391616008296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391616008297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391616008298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391616008299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391616008300 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616008301 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616008302 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616008303 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008304 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008306 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008307 Integrase core domain; Region: rve; pfam00665 391616008308 Integrase core domain; Region: rve_3; pfam13683 391616008309 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616008310 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 391616008311 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 391616008312 Protein of unknown function (DUF2805); Region: DUF2805; pfam10985 391616008313 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391616008314 ABC1 family; Region: ABC1; pfam03109 391616008315 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013 391616008316 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 391616008317 metal binding site [ion binding]; metal-binding site 391616008318 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391616008319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 391616008320 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391616008321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616008322 dimer interface [polypeptide binding]; other site 391616008323 conserved gate region; other site 391616008324 putative PBP binding loops; other site 391616008325 ABC-ATPase subunit interface; other site 391616008326 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391616008327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616008328 dimer interface [polypeptide binding]; other site 391616008329 conserved gate region; other site 391616008330 putative PBP binding loops; other site 391616008331 ABC-ATPase subunit interface; other site 391616008332 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391616008333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616008334 Walker A/P-loop; other site 391616008335 ATP binding site [chemical binding]; other site 391616008336 Q-loop/lid; other site 391616008337 ABC transporter signature motif; other site 391616008338 Walker B; other site 391616008339 D-loop; other site 391616008340 H-loop/switch region; other site 391616008341 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616008342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616008343 Walker A/P-loop; other site 391616008344 ATP binding site [chemical binding]; other site 391616008345 Q-loop/lid; other site 391616008346 ABC transporter signature motif; other site 391616008347 Walker B; other site 391616008348 D-loop; other site 391616008349 H-loop/switch region; other site 391616008350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391616008351 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616008352 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391616008353 NAD(P) binding site [chemical binding]; other site 391616008354 catalytic residues [active] 391616008355 catalytic residues [active] 391616008356 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391616008357 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391616008358 cleavage site 391616008359 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 391616008360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616008361 Walker A/P-loop; other site 391616008362 ATP binding site [chemical binding]; other site 391616008363 Q-loop/lid; other site 391616008364 ABC transporter signature motif; other site 391616008365 Walker B; other site 391616008366 D-loop; other site 391616008367 H-loop/switch region; other site 391616008368 TOBE domain; Region: TOBE; pfam03459 391616008369 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391616008370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616008371 dimer interface [polypeptide binding]; other site 391616008372 conserved gate region; other site 391616008373 putative PBP binding loops; other site 391616008374 ABC-ATPase subunit interface; other site 391616008375 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 391616008376 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616008377 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391616008378 nudix motif; other site 391616008379 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 391616008380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616008381 active site 391616008382 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391616008383 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 391616008384 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 391616008385 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391616008386 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391616008387 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391616008388 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 391616008389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616008390 Coenzyme A binding pocket [chemical binding]; other site 391616008391 EcsC protein family; Region: EcsC; pfam12787 391616008392 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 391616008393 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 391616008394 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391616008395 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391616008396 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391616008397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616008398 Coenzyme A binding pocket [chemical binding]; other site 391616008399 aspartate kinase; Reviewed; Region: PRK06635 391616008400 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391616008401 putative nucleotide binding site [chemical binding]; other site 391616008402 putative catalytic residues [active] 391616008403 putative Mg ion binding site [ion binding]; other site 391616008404 putative aspartate binding site [chemical binding]; other site 391616008405 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391616008406 putative allosteric regulatory site; other site 391616008407 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391616008408 putative allosteric regulatory residue; other site 391616008409 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391616008410 FAD binding domain; Region: FAD_binding_4; pfam01565 391616008411 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391616008412 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391616008413 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391616008414 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391616008415 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391616008416 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 391616008417 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 391616008418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008419 catalytic residue [active] 391616008420 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391616008421 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 391616008422 Subunit III/VIIa interface [polypeptide binding]; other site 391616008423 Phospholipid binding site [chemical binding]; other site 391616008424 Subunit I/III interface [polypeptide binding]; other site 391616008425 Subunit III/VIb interface [polypeptide binding]; other site 391616008426 Subunit III/VIa interface; other site 391616008427 Subunit III/Vb interface [polypeptide binding]; other site 391616008428 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 391616008429 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 391616008430 UbiA prenyltransferase family; Region: UbiA; pfam01040 391616008431 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 391616008432 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 391616008433 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391616008434 protease TldD; Provisional; Region: tldD; PRK10735 391616008435 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616008436 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 391616008437 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 391616008438 DNA protecting protein DprA; Region: dprA; TIGR00732 391616008439 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 391616008440 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 391616008441 active site 391616008442 interdomain interaction site; other site 391616008443 putative metal-binding site [ion binding]; other site 391616008444 nucleotide binding site [chemical binding]; other site 391616008445 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 391616008446 domain I; other site 391616008447 DNA binding groove [nucleotide binding] 391616008448 phosphate binding site [ion binding]; other site 391616008449 domain II; other site 391616008450 domain III; other site 391616008451 nucleotide binding site [chemical binding]; other site 391616008452 catalytic site [active] 391616008453 domain IV; other site 391616008454 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391616008455 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391616008456 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391616008457 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391616008458 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 391616008459 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 391616008460 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 391616008461 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 391616008462 FAD binding domain; Region: FAD_binding_4; pfam01565 391616008463 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 391616008464 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391616008465 classical (c) SDRs; Region: SDR_c; cd05233 391616008466 NAD(P) binding site [chemical binding]; other site 391616008467 active site 391616008468 hypothetical protein; Validated; Region: PRK08238 391616008469 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 391616008470 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616008471 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616008472 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616008473 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616008474 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 391616008475 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616008476 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616008477 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 391616008478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616008479 ATP binding site [chemical binding]; other site 391616008480 putative Mg++ binding site [ion binding]; other site 391616008481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616008482 nucleotide binding region [chemical binding]; other site 391616008483 ATP-binding site [chemical binding]; other site 391616008484 DEAD/H associated; Region: DEAD_assoc; pfam08494 391616008485 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616008486 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 391616008487 putative active site [active] 391616008488 putative metal binding site [ion binding]; other site 391616008489 LytTr DNA-binding domain; Region: LytTR; cl04498 391616008490 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 391616008491 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391616008492 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391616008493 homodimer interface [polypeptide binding]; other site 391616008494 NADP binding site [chemical binding]; other site 391616008495 substrate binding site [chemical binding]; other site 391616008496 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 391616008497 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 391616008498 Potassium binding sites [ion binding]; other site 391616008499 Cesium cation binding sites [ion binding]; other site 391616008500 MOSC domain; Region: MOSC; pfam03473 391616008501 FtsH Extracellular; Region: FtsH_ext; pfam06480 391616008502 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391616008503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616008504 Walker A motif; other site 391616008505 ATP binding site [chemical binding]; other site 391616008506 Walker B motif; other site 391616008507 arginine finger; other site 391616008508 Peptidase family M41; Region: Peptidase_M41; pfam01434 391616008509 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 391616008510 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391616008511 Ligand Binding Site [chemical binding]; other site 391616008512 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 391616008513 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 391616008514 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616008515 ligand binding site [chemical binding]; other site 391616008516 translocation protein TolB; Provisional; Region: tolB; PRK05137 391616008517 TolB amino-terminal domain; Region: TolB_N; pfam04052 391616008518 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391616008519 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391616008520 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391616008521 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391616008522 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 391616008523 TolR protein; Region: tolR; TIGR02801 391616008524 TolQ protein; Region: tolQ; TIGR02796 391616008525 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391616008526 active site 391616008527 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391616008528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616008529 Walker A motif; other site 391616008530 ATP binding site [chemical binding]; other site 391616008531 Walker B motif; other site 391616008532 arginine finger; other site 391616008533 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391616008534 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391616008535 RuvA N terminal domain; Region: RuvA_N; pfam01330 391616008536 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 391616008537 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 391616008538 active site 391616008539 putative DNA-binding cleft [nucleotide binding]; other site 391616008540 dimer interface [polypeptide binding]; other site 391616008541 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 391616008542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616008543 S-adenosylmethionine binding site [chemical binding]; other site 391616008544 primosome assembly protein PriA; Validated; Region: PRK05580 391616008545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616008546 ATP binding site [chemical binding]; other site 391616008547 putative Mg++ binding site [ion binding]; other site 391616008548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391616008549 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391616008550 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 391616008551 active site 391616008552 intersubunit interactions; other site 391616008553 catalytic residue [active] 391616008554 Protein of unknown function, DUF484; Region: DUF484; cl17449 391616008555 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391616008556 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616008557 active site 391616008558 DNA binding site [nucleotide binding] 391616008559 Int/Topo IB signature motif; other site 391616008560 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391616008561 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391616008562 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391616008563 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391616008564 DNA binding site [nucleotide binding] 391616008565 active site 391616008566 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 391616008567 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616008568 active site 391616008569 HIGH motif; other site 391616008570 nucleotide binding site [chemical binding]; other site 391616008571 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391616008572 active site 391616008573 KMSKS motif; other site 391616008574 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 391616008575 tRNA binding surface [nucleotide binding]; other site 391616008576 anticodon binding site; other site 391616008577 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391616008578 Membrane fusogenic activity; Region: BMFP; pfam04380 391616008579 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 391616008580 Uncharacterized conserved protein [Function unknown]; Region: COG1565 391616008581 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 391616008582 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 391616008583 Hint domain; Region: Hint_2; pfam13403 391616008584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616008585 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616008586 putative DNA binding site [nucleotide binding]; other site 391616008587 putative Zn2+ binding site [ion binding]; other site 391616008588 AsnC family; Region: AsnC_trans_reg; pfam01037 391616008589 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391616008590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616008591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616008592 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 391616008593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616008594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616008595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616008596 dimerization interface [polypeptide binding]; other site 391616008597 DoxX-like family; Region: DoxX_2; pfam13564 391616008598 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 391616008599 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 391616008600 ATP-sulfurylase; Region: ATPS; cd00517 391616008601 active site 391616008602 HXXH motif; other site 391616008603 flexible loop; other site 391616008604 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 391616008605 ligand-binding site [chemical binding]; other site 391616008606 Predicted deacylase [General function prediction only]; Region: COG3608 391616008607 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 391616008608 putative active site [active] 391616008609 Zn binding site [ion binding]; other site 391616008610 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 391616008611 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391616008612 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391616008613 putative dimer interface [polypeptide binding]; other site 391616008614 AIR carboxylase; Region: AIRC; pfam00731 391616008615 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391616008616 ATP-grasp domain; Region: ATP-grasp; pfam02222 391616008617 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616008618 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391616008619 nudix motif; other site 391616008620 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391616008621 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391616008622 ring oligomerisation interface [polypeptide binding]; other site 391616008623 ATP/Mg binding site [chemical binding]; other site 391616008624 stacking interactions; other site 391616008625 hinge regions; other site 391616008626 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391616008627 oligomerisation interface [polypeptide binding]; other site 391616008628 mobile loop; other site 391616008629 roof hairpin; other site 391616008630 Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929 391616008631 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 391616008632 DHH family; Region: DHH; pfam01368 391616008633 DHHA2 domain; Region: DHHA2; pfam02833 391616008634 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 391616008635 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 391616008636 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391616008637 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 391616008638 dimer interaction site [polypeptide binding]; other site 391616008639 substrate-binding tunnel; other site 391616008640 active site 391616008641 catalytic site [active] 391616008642 substrate binding site [chemical binding]; other site 391616008643 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391616008644 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391616008645 active site 391616008646 Riboflavin kinase; Region: Flavokinase; pfam01687 391616008647 hypothetical protein; Provisional; Region: PRK05170 391616008648 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 391616008649 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391616008650 tetramer interface [polypeptide binding]; other site 391616008651 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008652 catalytic residue [active] 391616008653 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 391616008654 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 391616008655 putative catalytic residue [active] 391616008656 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 391616008657 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391616008658 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616008659 active site 391616008660 H-type lectin domain; Region: H_lectin; pfam09458 391616008661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616008662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 391616008663 Integrase core domain; Region: rve; pfam00665 391616008664 Integrase core domain; Region: rve_3; pfam13683 391616008665 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616008666 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616008667 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616008668 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616008669 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391616008670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616008671 dimer interface [polypeptide binding]; other site 391616008672 phosphorylation site [posttranslational modification] 391616008673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616008674 ATP binding site [chemical binding]; other site 391616008675 Mg2+ binding site [ion binding]; other site 391616008676 G-X-G motif; other site 391616008677 hypothetical protein; Provisional; Region: PRK07482 391616008678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616008679 inhibitor-cofactor binding pocket; inhibition site 391616008680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008681 catalytic residue [active] 391616008682 succinic semialdehyde dehydrogenase; Region: PLN02278 391616008683 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391616008684 tetramerization interface [polypeptide binding]; other site 391616008685 NAD(P) binding site [chemical binding]; other site 391616008686 catalytic residues [active] 391616008687 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616008688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616008689 putative DNA binding site [nucleotide binding]; other site 391616008690 putative Zn2+ binding site [ion binding]; other site 391616008691 AsnC family; Region: AsnC_trans_reg; pfam01037 391616008692 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 391616008693 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 391616008694 putative active site [active] 391616008695 Zn binding site [ion binding]; other site 391616008696 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 391616008697 nucleotide binding site [chemical binding]; other site 391616008698 polymerase nucleotide-binding site; other site 391616008699 primase nucleotide-binding site [nucleotide binding]; other site 391616008700 DNA-binding residues [nucleotide binding]; DNA binding site 391616008701 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 391616008702 Integrase core domain; Region: rve; pfam00665 391616008703 Integrase core domain; Region: rve_3; pfam13683 391616008704 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 391616008705 Ligand binding site; other site 391616008706 Putative Catalytic site; other site 391616008707 DXD motif; other site 391616008708 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; pfam07578 391616008709 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 391616008710 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 391616008711 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 391616008712 active site 391616008713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 391616008714 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616008715 MULE transposase domain; Region: MULE; pfam10551 391616008716 Integrase core domain; Region: rve; pfam00665 391616008717 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616008718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616008719 Walker A motif; other site 391616008720 ATP binding site [chemical binding]; other site 391616008721 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391616008722 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616008723 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391616008724 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 391616008725 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 391616008726 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 391616008727 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616008728 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391616008729 Integrase core domain; Region: rve; pfam00665 391616008730 Integrase core domain; Region: rve_3; pfam13683 391616008731 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 391616008732 heme-binding site [chemical binding]; other site 391616008733 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 391616008734 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 391616008735 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 391616008736 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 391616008737 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391616008738 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 391616008739 active site 391616008740 metal binding site [ion binding]; metal-binding site 391616008741 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391616008742 Protein of unknown function (DUF952); Region: DUF952; pfam06108 391616008743 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 391616008744 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 391616008745 quinone interaction residues [chemical binding]; other site 391616008746 active site 391616008747 catalytic residues [active] 391616008748 FMN binding site [chemical binding]; other site 391616008749 substrate binding site [chemical binding]; other site 391616008750 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 391616008751 ArsC family; Region: ArsC; pfam03960 391616008752 catalytic residues [active] 391616008753 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 391616008754 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 391616008755 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391616008756 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 391616008757 CoenzymeA binding site [chemical binding]; other site 391616008758 subunit interaction site [polypeptide binding]; other site 391616008759 PHB binding site; other site 391616008760 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391616008761 CoenzymeA binding site [chemical binding]; other site 391616008762 subunit interaction site [polypeptide binding]; other site 391616008763 PHB binding site; other site 391616008764 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391616008765 DNA binding residues [nucleotide binding] 391616008766 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391616008767 putative dimer interface [polypeptide binding]; other site 391616008768 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391616008769 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391616008770 DNA binding residues [nucleotide binding] 391616008771 putative dimer interface [polypeptide binding]; other site 391616008772 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391616008773 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391616008774 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 391616008775 FAD binding site [chemical binding]; other site 391616008776 substrate binding site [chemical binding]; other site 391616008777 catalytic residues [active] 391616008778 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391616008779 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616008780 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391616008781 putative C-terminal domain interface [polypeptide binding]; other site 391616008782 putative GSH binding site (G-site) [chemical binding]; other site 391616008783 putative dimer interface [polypeptide binding]; other site 391616008784 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616008785 N-terminal domain interface [polypeptide binding]; other site 391616008786 dimer interface [polypeptide binding]; other site 391616008787 substrate binding pocket (H-site) [chemical binding]; other site 391616008788 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 391616008789 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391616008790 dimer interface [polypeptide binding]; other site 391616008791 active site 391616008792 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391616008793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616008794 substrate binding site [chemical binding]; other site 391616008795 oxyanion hole (OAH) forming residues; other site 391616008796 trimer interface [polypeptide binding]; other site 391616008797 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391616008798 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391616008799 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391616008800 Alternative oxidase; Region: AOX; pfam01786 391616008801 dinuclear metal binding motif [ion binding]; other site 391616008802 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391616008803 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616008804 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616008805 acyl-CoA synthetase; Validated; Region: PRK08162 391616008806 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391616008807 acyl-activating enzyme (AAE) consensus motif; other site 391616008808 putative active site [active] 391616008809 AMP binding site [chemical binding]; other site 391616008810 putative CoA binding site [chemical binding]; other site 391616008811 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391616008812 Ligand Binding Site [chemical binding]; other site 391616008813 BCCT family transporter; Region: BCCT; pfam02028 391616008814 Sporulation related domain; Region: SPOR; pfam05036 391616008815 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616008816 active site 391616008817 adenosine deaminase; Provisional; Region: PRK09358 391616008818 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 391616008819 active site 391616008820 phosphopentomutase; Provisional; Region: PRK05362 391616008821 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 391616008822 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 391616008823 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391616008824 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391616008825 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 391616008826 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 391616008827 active site 391616008828 catalytic motif [active] 391616008829 Zn binding site [ion binding]; other site 391616008830 Cupin domain; Region: Cupin_2; cl17218 391616008831 malic enzyme; Reviewed; Region: PRK12862 391616008832 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391616008833 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391616008834 putative NAD(P) binding site [chemical binding]; other site 391616008835 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391616008836 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 391616008837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391616008838 acyl-activating enzyme (AAE) consensus motif; other site 391616008839 AMP binding site [chemical binding]; other site 391616008840 active site 391616008841 CoA binding site [chemical binding]; other site 391616008842 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 391616008843 ATP-NAD kinase; Region: NAD_kinase; pfam01513 391616008844 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 391616008845 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391616008846 dimer interface [polypeptide binding]; other site 391616008847 active site 391616008848 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391616008849 folate binding site [chemical binding]; other site 391616008850 Protein of unknown function (DUF817); Region: DUF817; pfam05675 391616008851 acyl-CoA esterase; Provisional; Region: PRK10673 391616008852 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 391616008853 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616008854 Integrase core domain; Region: rve; pfam00665 391616008855 GTP-binding protein LepA; Provisional; Region: PRK05433 391616008856 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 391616008857 G1 box; other site 391616008858 putative GEF interaction site [polypeptide binding]; other site 391616008859 GTP/Mg2+ binding site [chemical binding]; other site 391616008860 Switch I region; other site 391616008861 G2 box; other site 391616008862 G3 box; other site 391616008863 Switch II region; other site 391616008864 G4 box; other site 391616008865 G5 box; other site 391616008866 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 391616008867 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391616008868 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391616008869 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391616008870 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391616008871 membrane ATPase/protein kinase; Provisional; Region: PRK09435 391616008872 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391616008873 Walker A; other site 391616008874 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 391616008875 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616008876 ATP binding site [chemical binding]; other site 391616008877 putative Mg++ binding site [ion binding]; other site 391616008878 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391616008879 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 391616008880 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391616008881 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 391616008882 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 391616008883 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 391616008884 active site 391616008885 catalytic triad [active] 391616008886 oxyanion hole [active] 391616008887 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008888 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008889 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008891 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391616008892 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391616008893 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391616008894 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 391616008895 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616008896 inhibitor-cofactor binding pocket; inhibition site 391616008897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616008898 catalytic residue [active] 391616008899 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616008900 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616008901 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616008902 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616008903 EamA-like transporter family; Region: EamA; pfam00892 391616008904 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616008905 EamA-like transporter family; Region: EamA; pfam00892 391616008906 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391616008907 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391616008908 GcrA cell cycle regulator; Region: GcrA; cl11564 391616008909 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 391616008910 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616008911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616008912 Winged helix-turn helix; Region: HTH_29; pfam13551 391616008913 Homeodomain-like domain; Region: HTH_32; pfam13565 391616008914 Winged helix-turn helix; Region: HTH_33; pfam13592 391616008915 Pirin-related protein [General function prediction only]; Region: COG1741 391616008916 Pirin; Region: Pirin; pfam02678 391616008917 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 391616008918 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 391616008919 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 391616008920 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 391616008921 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391616008922 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616008923 FeS/SAM binding site; other site 391616008924 SEFIR domain; Region: SEFIR; pfam08357 391616008925 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 391616008926 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 391616008927 Chitin binding Peritrophin-A domain; Region: CBM_14; pfam01607 391616008928 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391616008929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616008930 binding surface 391616008931 TPR motif; other site 391616008932 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 391616008933 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 391616008934 Peptidase family M48; Region: Peptidase_M48; cl12018 391616008935 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 391616008936 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391616008937 active site 391616008938 Zn binding site [ion binding]; other site 391616008939 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391616008940 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391616008941 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391616008942 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391616008943 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391616008944 homotrimer interaction site [polypeptide binding]; other site 391616008945 putative active site [active] 391616008946 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616008947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616008948 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616008949 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 391616008950 putative FMN binding site [chemical binding]; other site 391616008951 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 391616008952 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 391616008953 putative active site [active] 391616008954 putative catalytic site [active] 391616008955 putative Mg binding site IVb [ion binding]; other site 391616008956 putative phosphate binding site [ion binding]; other site 391616008957 putative DNA binding site [nucleotide binding]; other site 391616008958 putative Mg binding site IVa [ion binding]; other site 391616008959 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 391616008960 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616008961 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391616008962 dimer interface [polypeptide binding]; other site 391616008963 substrate binding site [chemical binding]; other site 391616008964 metal binding site [ion binding]; metal-binding site 391616008965 Response regulator receiver domain; Region: Response_reg; pfam00072 391616008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616008967 active site 391616008968 phosphorylation site [posttranslational modification] 391616008969 intermolecular recognition site; other site 391616008970 dimerization interface [polypeptide binding]; other site 391616008971 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391616008972 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616008973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 391616008974 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 391616008975 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391616008976 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391616008977 dimer interface [polypeptide binding]; other site 391616008978 anticodon binding site; other site 391616008979 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391616008980 motif 1; other site 391616008981 dimer interface [polypeptide binding]; other site 391616008982 active site 391616008983 motif 2; other site 391616008984 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391616008985 active site 391616008986 motif 3; other site 391616008987 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391616008988 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616008989 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616008990 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391616008991 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616008992 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616008993 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391616008994 IMP binding site; other site 391616008995 dimer interface [polypeptide binding]; other site 391616008996 interdomain contacts; other site 391616008997 partial ornithine binding site; other site 391616008998 H-NS histone family; Region: Histone_HNS; pfam00816 391616008999 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616009000 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616009001 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616009002 Integrase core domain; Region: rve; pfam00665 391616009003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616009004 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616009005 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616009006 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 391616009007 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616009008 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391616009009 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391616009010 thymidine kinase; Provisional; Region: PRK04296 391616009011 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391616009012 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391616009013 dimerization interface [polypeptide binding]; other site 391616009014 ligand binding site [chemical binding]; other site 391616009015 NADP binding site [chemical binding]; other site 391616009016 catalytic site [active] 391616009017 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 391616009018 dimer interface [polypeptide binding]; other site 391616009019 putative tRNA-binding site [nucleotide binding]; other site 391616009020 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391616009021 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391616009022 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 391616009023 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 391616009024 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 391616009025 oligomer interface [polypeptide binding]; other site 391616009026 active site 391616009027 metal binding site [ion binding]; metal-binding site 391616009028 hypothetical protein; Provisional; Region: PRK05415 391616009029 Domain of unknown function (DUF697); Region: DUF697; cl12064 391616009030 YcjX-like family, DUF463; Region: DUF463; pfam04317 391616009031 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391616009032 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 391616009033 dimerization interface 3.5A [polypeptide binding]; other site 391616009034 active site 391616009035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616009036 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391616009037 active site 391616009038 Surface antigen; Region: Bac_surface_Ag; pfam01103 391616009039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 391616009040 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391616009041 Family of unknown function (DUF490); Region: DUF490; pfam04357 391616009042 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 391616009043 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616009044 Walker A/P-loop; other site 391616009045 ATP binding site [chemical binding]; other site 391616009046 Q-loop/lid; other site 391616009047 ABC transporter signature motif; other site 391616009048 Walker B; other site 391616009049 D-loop; other site 391616009050 H-loop/switch region; other site 391616009051 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391616009052 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 391616009053 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616009054 Walker A/P-loop; other site 391616009055 ATP binding site [chemical binding]; other site 391616009056 Q-loop/lid; other site 391616009057 ABC transporter signature motif; other site 391616009058 Walker B; other site 391616009059 D-loop; other site 391616009060 H-loop/switch region; other site 391616009061 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391616009062 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 391616009063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009064 putative PBP binding loops; other site 391616009065 dimer interface [polypeptide binding]; other site 391616009066 ABC-ATPase subunit interface; other site 391616009067 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 391616009068 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 391616009069 peptide binding site [polypeptide binding]; other site 391616009070 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009071 Integrase core domain; Region: rve; pfam00665 391616009072 Integrase core domain; Region: rve_3; pfam13683 391616009073 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391616009074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009075 dimer interface [polypeptide binding]; other site 391616009076 conserved gate region; other site 391616009077 putative PBP binding loops; other site 391616009078 ABC-ATPase subunit interface; other site 391616009079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009080 putative PBP binding loops; other site 391616009081 dimer interface [polypeptide binding]; other site 391616009082 ABC-ATPase subunit interface; other site 391616009083 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391616009084 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391616009085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616009086 Walker A/P-loop; other site 391616009087 ATP binding site [chemical binding]; other site 391616009088 Q-loop/lid; other site 391616009089 ABC transporter signature motif; other site 391616009090 Walker B; other site 391616009091 D-loop; other site 391616009092 H-loop/switch region; other site 391616009093 TOBE domain; Region: TOBE_2; pfam08402 391616009094 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391616009095 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391616009096 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 391616009097 active site 391616009098 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009099 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009100 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009102 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 391616009103 homodimer interface [polypeptide binding]; other site 391616009104 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 391616009105 active site pocket [active] 391616009106 glycogen branching enzyme; Provisional; Region: PRK05402 391616009107 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 391616009108 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 391616009109 active site 391616009110 catalytic site [active] 391616009111 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 391616009112 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 391616009113 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 391616009114 ligand binding site; other site 391616009115 oligomer interface; other site 391616009116 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 391616009117 dimer interface [polypeptide binding]; other site 391616009118 N-terminal domain interface [polypeptide binding]; other site 391616009119 sulfate 1 binding site; other site 391616009120 glycogen synthase; Provisional; Region: glgA; PRK00654 391616009121 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 391616009122 ADP-binding pocket [chemical binding]; other site 391616009123 homodimer interface [polypeptide binding]; other site 391616009124 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 391616009125 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 391616009126 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 391616009127 active site 391616009128 catalytic site [active] 391616009129 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 391616009130 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 391616009131 phosphoglucomutase; Region: PLN02307 391616009132 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 391616009133 active site 391616009134 substrate binding site [chemical binding]; other site 391616009135 metal binding site [ion binding]; metal-binding site 391616009136 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391616009137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616009138 NAD binding site [chemical binding]; other site 391616009139 catalytic residues [active] 391616009140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616009141 non-specific DNA binding site [nucleotide binding]; other site 391616009142 salt bridge; other site 391616009143 sequence-specific DNA binding site [nucleotide binding]; other site 391616009144 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391616009145 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391616009146 putative catalytic cysteine [active] 391616009147 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391616009148 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391616009149 gamma-glutamyl kinase; Provisional; Region: PRK05429 391616009150 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391616009151 nucleotide binding site [chemical binding]; other site 391616009152 homotetrameric interface [polypeptide binding]; other site 391616009153 putative phosphate binding site [ion binding]; other site 391616009154 putative allosteric binding site; other site 391616009155 PUA domain; Region: PUA; pfam01472 391616009156 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 391616009157 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 391616009158 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 391616009159 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 391616009160 RNA binding site [nucleotide binding]; other site 391616009161 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 391616009162 proposed catalytic triad [active] 391616009163 active site nucleophile [active] 391616009164 cyanophycin synthetase; Provisional; Region: PRK14016 391616009165 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 391616009166 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616009167 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616009168 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391616009169 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616009170 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391616009171 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391616009172 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 391616009173 catalytic nucleophile [active] 391616009174 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 391616009175 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391616009176 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391616009177 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391616009178 putative active site [active] 391616009179 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391616009180 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391616009181 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616009182 DctM-like transporters; Region: DctM; pfam06808 391616009183 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616009184 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391616009185 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391616009186 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391616009187 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391616009188 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 391616009189 NAD(P) binding site [chemical binding]; other site 391616009190 catalytic residues [active] 391616009191 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391616009192 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391616009193 putative active site [active] 391616009194 metal binding site [ion binding]; metal-binding site 391616009195 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391616009196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616009197 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391616009198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616009199 Walker A/P-loop; other site 391616009200 ATP binding site [chemical binding]; other site 391616009201 Q-loop/lid; other site 391616009202 ABC transporter signature motif; other site 391616009203 Walker B; other site 391616009204 D-loop; other site 391616009205 H-loop/switch region; other site 391616009206 TOBE domain; Region: TOBE_2; pfam08402 391616009207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009208 dimer interface [polypeptide binding]; other site 391616009209 conserved gate region; other site 391616009210 putative PBP binding loops; other site 391616009211 ABC-ATPase subunit interface; other site 391616009212 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391616009213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009214 putative PBP binding loops; other site 391616009215 dimer interface [polypeptide binding]; other site 391616009216 ABC-ATPase subunit interface; other site 391616009217 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616009218 MULE transposase domain; Region: MULE; pfam10551 391616009219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616009220 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616009221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616009222 Transposase; Region: HTH_Tnp_1; cl17663 391616009223 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009224 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009225 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009226 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009227 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009228 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009229 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009231 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009232 Integrase core domain; Region: rve; pfam00665 391616009233 Integrase core domain; Region: rve_3; pfam13683 391616009234 cytosine deaminase; Validated; Region: PRK07572 391616009235 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 391616009236 active site 391616009237 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616009238 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616009239 TM-ABC transporter signature motif; other site 391616009240 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616009241 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616009242 TM-ABC transporter signature motif; other site 391616009243 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391616009244 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616009245 Walker A/P-loop; other site 391616009246 ATP binding site [chemical binding]; other site 391616009247 Q-loop/lid; other site 391616009248 ABC transporter signature motif; other site 391616009249 Walker B; other site 391616009250 D-loop; other site 391616009251 H-loop/switch region; other site 391616009252 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616009253 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391616009254 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391616009255 putative ligand binding site [chemical binding]; other site 391616009256 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009257 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009258 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009259 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009260 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616009261 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391616009262 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391616009263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009264 dimer interface [polypeptide binding]; other site 391616009265 conserved gate region; other site 391616009266 putative PBP binding loops; other site 391616009267 ABC-ATPase subunit interface; other site 391616009268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616009269 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391616009270 Walker A/P-loop; other site 391616009271 ATP binding site [chemical binding]; other site 391616009272 Q-loop/lid; other site 391616009273 ABC transporter signature motif; other site 391616009274 Walker B; other site 391616009275 D-loop; other site 391616009276 H-loop/switch region; other site 391616009277 Integrase core domain; Region: rve; pfam00665 391616009278 Integrase core domain; Region: rve_3; pfam13683 391616009279 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009280 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009281 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009283 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616009284 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616009285 Integrase core domain; Region: rve; pfam00665 391616009286 YHYH protein; Region: YHYH; pfam14240 391616009287 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391616009288 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616009289 Walker A/P-loop; other site 391616009290 ATP binding site [chemical binding]; other site 391616009291 Q-loop/lid; other site 391616009292 ABC transporter signature motif; other site 391616009293 Walker B; other site 391616009294 D-loop; other site 391616009295 H-loop/switch region; other site 391616009296 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391616009297 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616009298 Walker A/P-loop; other site 391616009299 ATP binding site [chemical binding]; other site 391616009300 Q-loop/lid; other site 391616009301 ABC transporter signature motif; other site 391616009302 Walker B; other site 391616009303 D-loop; other site 391616009304 H-loop/switch region; other site 391616009305 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616009306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616009307 TM-ABC transporter signature motif; other site 391616009308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616009309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616009310 TM-ABC transporter signature motif; other site 391616009311 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391616009312 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 391616009313 putative ligand binding site [chemical binding]; other site 391616009314 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 391616009315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 391616009316 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616009317 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616009318 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009319 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009320 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009322 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391616009323 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616009324 Walker A/P-loop; other site 391616009325 ATP binding site [chemical binding]; other site 391616009326 Q-loop/lid; other site 391616009327 ABC transporter signature motif; other site 391616009328 Walker B; other site 391616009329 D-loop; other site 391616009330 H-loop/switch region; other site 391616009331 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616009332 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616009333 TM-ABC transporter signature motif; other site 391616009334 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391616009335 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616009336 putative ligand binding site [chemical binding]; other site 391616009337 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616009338 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616009339 DNA binding site [nucleotide binding] 391616009340 domain linker motif; other site 391616009341 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391616009342 putative dimerization interface [polypeptide binding]; other site 391616009343 putative ligand binding site [chemical binding]; other site 391616009344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616009345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616009346 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616009347 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391616009348 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616009349 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616009350 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616009351 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391616009352 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616009353 dimer interface [polypeptide binding]; other site 391616009354 PYR/PP interface [polypeptide binding]; other site 391616009355 TPP binding site [chemical binding]; other site 391616009356 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391616009357 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391616009358 TPP-binding site [chemical binding]; other site 391616009359 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 391616009360 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616009361 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391616009362 substrate binding site [chemical binding]; other site 391616009363 ATP binding site [chemical binding]; other site 391616009364 KduI/IolB family; Region: KduI; pfam04962 391616009365 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391616009366 intersubunit interface [polypeptide binding]; other site 391616009367 active site 391616009368 zinc binding site [ion binding]; other site 391616009369 Na+ binding site [ion binding]; other site 391616009370 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616009371 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616009372 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391616009373 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391616009374 kynureninase; Region: kynureninase; TIGR01814 391616009375 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391616009376 catalytic residue [active] 391616009377 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616009378 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616009379 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616009380 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616009381 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616009382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616009383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616009384 dimerization interface [polypeptide binding]; other site 391616009385 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391616009386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616009387 NAD(P) binding site [chemical binding]; other site 391616009388 active site 391616009389 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 391616009390 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 391616009391 substrate binding site [chemical binding]; other site 391616009392 hexamer interface [polypeptide binding]; other site 391616009393 metal binding site [ion binding]; metal-binding site 391616009394 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 391616009395 Helix-turn-helix domain; Region: HTH_18; pfam12833 391616009396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616009397 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391616009398 intersubunit interface [polypeptide binding]; other site 391616009399 active site 391616009400 catalytic residue [active] 391616009401 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391616009402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616009403 NAD(P) binding site [chemical binding]; other site 391616009404 catalytic residues [active] 391616009405 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616009406 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391616009407 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 391616009408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616009409 Walker A motif; other site 391616009410 ATP binding site [chemical binding]; other site 391616009411 Walker B motif; other site 391616009412 arginine finger; other site 391616009413 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391616009414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391616009415 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 391616009416 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391616009417 putative NAD(P) binding site [chemical binding]; other site 391616009418 active site 391616009419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391616009420 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 391616009421 succinic semialdehyde dehydrogenase; Region: PLN02278 391616009422 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391616009423 tetramerization interface [polypeptide binding]; other site 391616009424 NAD(P) binding site [chemical binding]; other site 391616009425 catalytic residues [active] 391616009426 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 391616009427 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391616009428 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391616009429 FAD binding domain; Region: FAD_binding_4; pfam01565 391616009430 Berberine and berberine like; Region: BBE; pfam08031 391616009431 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391616009432 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 391616009433 conserved cys residue [active] 391616009434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616009435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616009436 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 391616009437 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 391616009438 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616009439 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391616009440 DNA binding residues [nucleotide binding] 391616009441 von Willebrand factor; Region: vWF_A; pfam12450 391616009442 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 391616009443 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 391616009444 metal ion-dependent adhesion site (MIDAS); other site 391616009445 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 391616009446 Predicted transcriptional regulator [Transcription]; Region: COG2378 391616009447 HTH domain; Region: HTH_11; pfam08279 391616009448 WYL domain; Region: WYL; pfam13280 391616009449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616009450 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391616009451 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391616009452 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 391616009453 MoxR-like ATPases [General function prediction only]; Region: COG0714 391616009454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616009455 Walker A motif; other site 391616009456 ATP binding site [chemical binding]; other site 391616009457 Walker B motif; other site 391616009458 arginine finger; other site 391616009459 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391616009460 Protein of unknown function DUF58; Region: DUF58; pfam01882 391616009461 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391616009462 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 391616009463 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 391616009464 Protein of unknown function, DUF599; Region: DUF599; pfam04654 391616009465 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 391616009466 FAD binding domain; Region: FAD_binding_4; pfam01565 391616009467 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 391616009468 FAD binding domain; Region: FAD_binding_4; pfam01565 391616009469 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 391616009470 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391616009471 Cysteine-rich domain; Region: CCG; pfam02754 391616009472 Cysteine-rich domain; Region: CCG; pfam02754 391616009473 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391616009474 active site 391616009475 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391616009476 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391616009477 putative dimer interface [polypeptide binding]; other site 391616009478 DNA polymerase I; Provisional; Region: PRK05755 391616009479 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391616009480 active site 391616009481 metal binding site 1 [ion binding]; metal-binding site 391616009482 putative 5' ssDNA interaction site; other site 391616009483 metal binding site 3; metal-binding site 391616009484 metal binding site 2 [ion binding]; metal-binding site 391616009485 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391616009486 putative DNA binding site [nucleotide binding]; other site 391616009487 putative metal binding site [ion binding]; other site 391616009488 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 391616009489 active site 391616009490 catalytic site [active] 391616009491 substrate binding site [chemical binding]; other site 391616009492 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391616009493 active site 391616009494 DNA binding site [nucleotide binding] 391616009495 catalytic site [active] 391616009496 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616009497 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616009498 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616009499 Zinc-finger domain; Region: zf-CHCC; pfam10276 391616009500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391616009501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616009502 Walker A/P-loop; other site 391616009503 ATP binding site [chemical binding]; other site 391616009504 Q-loop/lid; other site 391616009505 ABC transporter signature motif; other site 391616009506 Walker B; other site 391616009507 D-loop; other site 391616009508 H-loop/switch region; other site 391616009509 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 391616009510 nucleotide binding site/active site [active] 391616009511 HIT family signature motif; other site 391616009512 catalytic residue [active] 391616009513 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391616009514 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009515 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009516 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009518 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391616009519 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 391616009520 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616009521 substrate binding site [chemical binding]; other site 391616009522 ATP binding site [chemical binding]; other site 391616009523 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391616009524 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391616009525 minor groove reading motif; other site 391616009526 helix-hairpin-helix signature motif; other site 391616009527 substrate binding pocket [chemical binding]; other site 391616009528 active site 391616009529 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391616009530 Helix-turn-helix domain; Region: HTH_18; pfam12833 391616009531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616009532 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391616009533 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391616009534 DNA binding site [nucleotide binding] 391616009535 active site 391616009536 putative outer membrane lipoprotein; Provisional; Region: PRK10510 391616009537 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616009538 ligand binding site [chemical binding]; other site 391616009539 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 391616009540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616009541 DNA-binding site [nucleotide binding]; DNA binding site 391616009542 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391616009543 F0F1 ATP synthase subunit B; Provisional; Region: PRK13455 391616009544 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 391616009545 F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454 391616009546 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 391616009547 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 391616009548 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 391616009549 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 391616009550 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 391616009551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616009552 dimerization interface [polypeptide binding]; other site 391616009553 putative DNA binding site [nucleotide binding]; other site 391616009554 putative Zn2+ binding site [ion binding]; other site 391616009555 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616009556 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616009557 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616009558 dimerization interface [polypeptide binding]; other site 391616009559 signal recognition particle protein; Provisional; Region: PRK10867 391616009560 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391616009561 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391616009562 P loop; other site 391616009563 GTP binding site [chemical binding]; other site 391616009564 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391616009565 NIPSNAP; Region: NIPSNAP; pfam07978 391616009566 chorismate mutase; Provisional; Region: PRK09239 391616009567 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 391616009568 RimM N-terminal domain; Region: RimM; pfam01782 391616009569 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 391616009570 PRC-barrel domain; Region: PRC; pfam05239 391616009571 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 391616009572 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616009573 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616009574 Integrase core domain; Region: rve; pfam00665 391616009575 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616009576 MULE transposase domain; Region: MULE; pfam10551 391616009577 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009578 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009579 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616009582 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616009583 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009584 Integrase core domain; Region: rve; pfam00665 391616009585 Integrase core domain; Region: rve_3; pfam13683 391616009586 Predicted HD phosphohydrolase [General function prediction only]; Region: COG4341 391616009587 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 391616009588 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 391616009589 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391616009590 Cupin domain; Region: Cupin_2; pfam07883 391616009591 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 391616009592 Phosphate transporter family; Region: PHO4; pfam01384 391616009593 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391616009594 nudix motif; other site 391616009595 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391616009596 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391616009597 ATP binding site [chemical binding]; other site 391616009598 Mg++ binding site [ion binding]; other site 391616009599 motif III; other site 391616009600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616009601 nucleotide binding region [chemical binding]; other site 391616009602 ATP-binding site [chemical binding]; other site 391616009603 ATPase MipZ; Region: MipZ; pfam09140 391616009604 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391616009605 P-loop; other site 391616009606 Magnesium ion binding site [ion binding]; other site 391616009607 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391616009608 Magnesium ion binding site [ion binding]; other site 391616009609 aminotransferase; Validated; Region: PRK07678 391616009610 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616009611 inhibitor-cofactor binding pocket; inhibition site 391616009612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616009613 catalytic residue [active] 391616009614 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009615 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009616 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009617 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616009619 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616009620 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616009621 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391616009622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616009623 DNA-binding site [nucleotide binding]; DNA binding site 391616009624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616009625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616009626 homodimer interface [polypeptide binding]; other site 391616009627 catalytic residue [active] 391616009628 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391616009629 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616009630 PYR/PP interface [polypeptide binding]; other site 391616009631 dimer interface [polypeptide binding]; other site 391616009632 TPP binding site [chemical binding]; other site 391616009633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391616009634 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391616009635 TPP-binding site [chemical binding]; other site 391616009636 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 391616009637 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 391616009638 propionate/acetate kinase; Provisional; Region: PRK12379 391616009639 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391616009640 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391616009641 molybdopterin cofactor binding site; other site 391616009642 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391616009643 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391616009644 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 391616009645 putative molybdopterin cofactor binding site; other site 391616009646 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 391616009647 4Fe-4S binding domain; Region: Fer4; pfam00037 391616009648 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 391616009649 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391616009650 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616009651 Walker A/P-loop; other site 391616009652 ATP binding site [chemical binding]; other site 391616009653 Q-loop/lid; other site 391616009654 ABC transporter signature motif; other site 391616009655 Walker B; other site 391616009656 D-loop; other site 391616009657 H-loop/switch region; other site 391616009658 TOBE domain; Region: TOBE_2; pfam08402 391616009659 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616009660 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391616009661 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616009662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616009663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616009664 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391616009665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009666 dimer interface [polypeptide binding]; other site 391616009667 conserved gate region; other site 391616009668 putative PBP binding loops; other site 391616009669 ABC-ATPase subunit interface; other site 391616009670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616009671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009672 dimer interface [polypeptide binding]; other site 391616009673 conserved gate region; other site 391616009674 putative PBP binding loops; other site 391616009675 ABC-ATPase subunit interface; other site 391616009676 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 391616009677 Melibiase; Region: Melibiase; pfam02065 391616009678 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391616009679 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391616009680 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 391616009681 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391616009682 active site 391616009683 intersubunit interface [polypeptide binding]; other site 391616009684 catalytic residue [active] 391616009685 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391616009686 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 391616009687 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 391616009688 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391616009689 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 391616009690 active site 391616009691 catalytic residues [active] 391616009692 5-oxoprolinase; Region: PLN02666 391616009693 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391616009694 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391616009695 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391616009696 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391616009697 FAD binding domain; Region: FAD_binding_4; pfam01565 391616009698 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391616009699 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 391616009700 domain interfaces; other site 391616009701 active site 391616009702 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 391616009703 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 391616009704 substrate binding site [chemical binding]; other site 391616009705 active site 391616009706 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 391616009707 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 391616009708 Transcription factor involved in TATA site selection and in elongation by RNA polymerase II [Transcription]; Region: COG5296 391616009709 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391616009710 classical (c) SDRs; Region: SDR_c; cd05233 391616009711 NAD(P) binding site [chemical binding]; other site 391616009712 active site 391616009713 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 391616009714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616009715 S-adenosylmethionine binding site [chemical binding]; other site 391616009716 Uncharacterized conserved protein [Function unknown]; Region: COG2127 391616009717 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391616009718 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391616009719 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391616009720 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391616009721 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391616009722 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391616009723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616009724 Walker A/P-loop; other site 391616009725 ATP binding site [chemical binding]; other site 391616009726 Q-loop/lid; other site 391616009727 ABC transporter signature motif; other site 391616009728 Walker B; other site 391616009729 D-loop; other site 391616009730 H-loop/switch region; other site 391616009731 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616009732 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616009733 Walker A/P-loop; other site 391616009734 ATP binding site [chemical binding]; other site 391616009735 Q-loop/lid; other site 391616009736 ABC transporter signature motif; other site 391616009737 Walker B; other site 391616009738 D-loop; other site 391616009739 H-loop/switch region; other site 391616009740 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616009741 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 391616009742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009743 dimer interface [polypeptide binding]; other site 391616009744 conserved gate region; other site 391616009745 putative PBP binding loops; other site 391616009746 ABC-ATPase subunit interface; other site 391616009747 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 391616009748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009749 putative PBP binding loops; other site 391616009750 dimer interface [polypeptide binding]; other site 391616009751 ABC-ATPase subunit interface; other site 391616009752 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391616009753 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391616009754 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391616009755 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391616009756 prephenate dehydratase; Provisional; Region: PRK11899 391616009757 Prephenate dehydratase; Region: PDT; pfam00800 391616009758 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391616009759 putative L-Phe binding site [chemical binding]; other site 391616009760 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 391616009761 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 391616009762 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 391616009763 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391616009764 putative NADH binding site [chemical binding]; other site 391616009765 putative active site [active] 391616009766 nudix motif; other site 391616009767 putative metal binding site [ion binding]; other site 391616009768 GTPase RsgA; Reviewed; Region: PRK01889 391616009769 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 391616009770 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391616009771 GTP/Mg2+ binding site [chemical binding]; other site 391616009772 G4 box; other site 391616009773 G5 box; other site 391616009774 G1 box; other site 391616009775 Switch I region; other site 391616009776 G2 box; other site 391616009777 G3 box; other site 391616009778 Switch II region; other site 391616009779 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 391616009780 active site 391616009781 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 391616009782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616009783 Walker A motif; other site 391616009784 ATP binding site [chemical binding]; other site 391616009785 Walker B motif; other site 391616009786 arginine finger; other site 391616009787 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391616009788 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 391616009789 hypothetical protein; Validated; Region: PRK00153 391616009790 recombination protein RecR; Reviewed; Region: recR; PRK00076 391616009791 RecR protein; Region: RecR; pfam02132 391616009792 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391616009793 putative active site [active] 391616009794 putative metal-binding site [ion binding]; other site 391616009795 tetramer interface [polypeptide binding]; other site 391616009796 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 391616009797 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 391616009798 B1 nucleotide binding pocket [chemical binding]; other site 391616009799 B2 nucleotide binding pocket [chemical binding]; other site 391616009800 CAS motifs; other site 391616009801 active site 391616009802 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616009803 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616009804 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616009805 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009806 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009807 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009808 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009809 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009810 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009811 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009813 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616009814 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616009815 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616009816 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616009817 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616009818 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616009819 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391616009820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616009821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616009822 ATP binding site [chemical binding]; other site 391616009823 Mg2+ binding site [ion binding]; other site 391616009824 G-X-G motif; other site 391616009825 mercuric reductase; Validated; Region: PRK06370 391616009826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616009827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616009828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616009829 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 391616009830 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391616009831 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616009832 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616009833 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616009834 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616009835 Ribonuclease P; Region: Ribonuclease_P; pfam00825 391616009836 Haemolytic domain; Region: Haemolytic; pfam01809 391616009837 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 391616009838 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 391616009839 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 391616009840 Ligand Binding Site [chemical binding]; other site 391616009841 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616009842 membrane protein insertase; Provisional; Region: PRK01318 391616009843 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 391616009844 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391616009845 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391616009846 MOSC domain; Region: MOSC; pfam03473 391616009847 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 391616009848 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 391616009849 G1 box; other site 391616009850 GTP/Mg2+ binding site [chemical binding]; other site 391616009851 Switch I region; other site 391616009852 G2 box; other site 391616009853 G3 box; other site 391616009854 Switch II region; other site 391616009855 G4 box; other site 391616009856 G5 box; other site 391616009857 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 391616009858 feedback inhibition sensing region; other site 391616009859 homohexameric interface [polypeptide binding]; other site 391616009860 nucleotide binding site [chemical binding]; other site 391616009861 N-acetyl-L-glutamate binding site [chemical binding]; other site 391616009862 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 391616009863 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391616009864 catalytic core [active] 391616009865 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391616009866 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391616009867 Walker A/P-loop; other site 391616009868 ATP binding site [chemical binding]; other site 391616009869 Q-loop/lid; other site 391616009870 ABC transporter signature motif; other site 391616009871 Walker B; other site 391616009872 D-loop; other site 391616009873 H-loop/switch region; other site 391616009874 RNA polymerase sigma factor; Provisional; Region: PRK12540 391616009875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009876 dimer interface [polypeptide binding]; other site 391616009877 conserved gate region; other site 391616009878 putative PBP binding loops; other site 391616009879 ABC-ATPase subunit interface; other site 391616009880 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 391616009881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616009882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616009883 dimer interface [polypeptide binding]; other site 391616009884 ABC-ATPase subunit interface; other site 391616009885 putative PBP binding loops; other site 391616009886 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 391616009887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391616009888 substrate binding pocket [chemical binding]; other site 391616009889 membrane-bound complex binding site; other site 391616009890 hinge residues; other site 391616009891 ATP12 chaperone protein; Region: ATP12; cl02228 391616009892 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391616009893 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391616009894 RNA binding surface [nucleotide binding]; other site 391616009895 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391616009896 active site 391616009897 camphor resistance protein CrcB; Provisional; Region: PRK14195 391616009898 recombination factor protein RarA; Reviewed; Region: PRK13342 391616009899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616009900 Walker A motif; other site 391616009901 ATP binding site [chemical binding]; other site 391616009902 Walker B motif; other site 391616009903 arginine finger; other site 391616009904 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 391616009905 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 391616009906 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391616009907 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391616009908 alphaNTD - beta interaction site [polypeptide binding]; other site 391616009909 alphaNTD homodimer interface [polypeptide binding]; other site 391616009910 alphaNTD - beta' interaction site [polypeptide binding]; other site 391616009911 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 391616009912 30S ribosomal protein S11; Validated; Region: PRK05309 391616009913 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391616009914 30S ribosomal protein S13; Region: bact_S13; TIGR03631 391616009915 adenylate kinase; Reviewed; Region: adk; PRK00279 391616009916 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391616009917 AMP-binding site [chemical binding]; other site 391616009918 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391616009919 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391616009920 SecY translocase; Region: SecY; pfam00344 391616009921 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 391616009922 threonine dehydratase; Provisional; Region: PRK07334 391616009923 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391616009924 tetramer interface [polypeptide binding]; other site 391616009925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616009926 catalytic residue [active] 391616009927 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 391616009928 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 391616009929 23S rRNA binding site [nucleotide binding]; other site 391616009930 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391616009931 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391616009932 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391616009933 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391616009934 5S rRNA interface [nucleotide binding]; other site 391616009935 L27 interface [polypeptide binding]; other site 391616009936 23S rRNA interface [nucleotide binding]; other site 391616009937 L5 interface [polypeptide binding]; other site 391616009938 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391616009939 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391616009940 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391616009941 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 391616009942 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 391616009943 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391616009944 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391616009945 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391616009946 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 391616009947 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 391616009948 RNA binding site [nucleotide binding]; other site 391616009949 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 391616009950 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 391616009951 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 391616009952 putative translocon interaction site; other site 391616009953 23S rRNA interface [nucleotide binding]; other site 391616009954 signal recognition particle (SRP54) interaction site; other site 391616009955 L23 interface [polypeptide binding]; other site 391616009956 trigger factor interaction site; other site 391616009957 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616009958 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616009959 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616009960 Integrase core domain; Region: rve; pfam00665 391616009961 Integrase core domain; Region: rve_3; pfam13683 391616009962 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616009963 Integrase core domain; Region: rve; pfam00665 391616009964 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391616009965 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391616009966 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391616009967 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 391616009968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391616009969 putative translocon binding site; other site 391616009970 protein-rRNA interface [nucleotide binding]; other site 391616009971 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391616009972 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 391616009973 G-X-X-G motif; other site 391616009974 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391616009975 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391616009976 23S rRNA interface [nucleotide binding]; other site 391616009977 5S rRNA interface [nucleotide binding]; other site 391616009978 putative antibiotic binding site [chemical binding]; other site 391616009979 L25 interface [polypeptide binding]; other site 391616009980 L27 interface [polypeptide binding]; other site 391616009981 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616009982 MULE transposase domain; Region: MULE; pfam10551 391616009983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616009984 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616009985 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616009986 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 391616009987 conserved hypothetical protein; Region: TIGR02466 391616009988 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616009989 Winged helix-turn helix; Region: HTH_29; pfam13551 391616009990 Winged helix-turn helix; Region: HTH_33; pfam13592 391616009991 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616009992 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616009993 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391616009994 23S rRNA binding site [nucleotide binding]; other site 391616009995 L21 binding site [polypeptide binding]; other site 391616009996 L13 binding site [polypeptide binding]; other site 391616009997 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 391616009998 pyruvate kinase; Provisional; Region: PRK06247 391616009999 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 391616010000 domain interfaces; other site 391616010001 active site 391616010002 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391616010003 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 391616010004 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391616010005 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391616010006 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616010007 ligand binding site [chemical binding]; other site 391616010008 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391616010009 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391616010010 homodimer interface [polypeptide binding]; other site 391616010011 substrate-cofactor binding pocket; other site 391616010012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616010013 catalytic residue [active] 391616010014 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 391616010015 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 391616010016 active site 391616010017 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391616010018 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391616010019 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010020 active site 391616010021 Int/Topo IB signature motif; other site 391616010022 DNA binding site [nucleotide binding] 391616010023 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616010024 Putative transposase; Region: Y2_Tnp; pfam04986 391616010025 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616010026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616010027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616010028 dimerization interface [polypeptide binding]; other site 391616010029 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616010030 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616010031 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616010032 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616010033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391616010034 active site 391616010035 metal binding site [ion binding]; metal-binding site 391616010036 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616010037 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 391616010038 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 391616010039 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 391616010040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391616010041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391616010042 putative acyl-acceptor binding pocket; other site 391616010043 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 391616010044 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 391616010045 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391616010046 Walker A/P-loop; other site 391616010047 ATP binding site [chemical binding]; other site 391616010048 Q-loop/lid; other site 391616010049 ABC transporter signature motif; other site 391616010050 Walker B; other site 391616010051 D-loop; other site 391616010052 H-loop/switch region; other site 391616010053 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 391616010054 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 391616010055 diaminopimelate decarboxylase; Region: lysA; TIGR01048 391616010056 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391616010057 active site 391616010058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391616010059 substrate binding site [chemical binding]; other site 391616010060 catalytic residues [active] 391616010061 dimer interface [polypeptide binding]; other site 391616010062 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 391616010063 argininosuccinate lyase; Provisional; Region: PRK00855 391616010064 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391616010065 active sites [active] 391616010066 tetramer interface [polypeptide binding]; other site 391616010067 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391616010068 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391616010069 catalytic residues [active] 391616010070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616010071 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616010072 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616010073 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616010074 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616010075 Integrase core domain; Region: rve; pfam00665 391616010076 Integrase core domain; Region: rve_3; pfam13683 391616010077 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616010078 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616010079 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616010080 Integrase core domain; Region: rve; pfam00665 391616010081 Winged helix-turn helix; Region: HTH_29; pfam13551 391616010082 Winged helix-turn helix; Region: HTH_33; pfam13592 391616010083 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616010084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616010085 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616010086 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616010087 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 391616010088 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391616010089 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616010090 ligand binding site [chemical binding]; other site 391616010091 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 391616010092 UbiA prenyltransferase family; Region: UbiA; pfam01040 391616010093 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 391616010094 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616010095 glutamate--cysteine ligase; Region: PLN02611 391616010096 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 391616010097 dihydroorotase; Validated; Region: PRK09059 391616010098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616010099 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 391616010100 active site 391616010101 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 391616010102 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391616010103 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391616010104 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391616010105 Fe-S cluster binding site [ion binding]; other site 391616010106 active site 391616010107 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 391616010108 MPT binding site; other site 391616010109 trimer interface [polypeptide binding]; other site 391616010110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391616010111 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616010112 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391616010113 Protein export membrane protein; Region: SecD_SecF; cl14618 391616010114 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 391616010115 Putative transcriptional regulator [Transcription]; Region: COG1678 391616010116 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391616010117 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 391616010118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616010119 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391616010120 active site 391616010121 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391616010122 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391616010123 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391616010124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616010125 putative DNA binding site [nucleotide binding]; other site 391616010126 putative Zn2+ binding site [ion binding]; other site 391616010127 AsnC family; Region: AsnC_trans_reg; pfam01037 391616010128 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 391616010129 AzlC protein; Region: AzlC; pfam03591 391616010130 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391616010131 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391616010132 GTP binding site; other site 391616010133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391616010134 Coenzyme A binding pocket [chemical binding]; other site 391616010135 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391616010136 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 391616010137 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 391616010138 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 391616010139 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616010140 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 391616010141 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 391616010142 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 391616010143 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010144 TPR motif; other site 391616010145 binding surface 391616010146 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391616010147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010148 TPR motif; other site 391616010149 binding surface 391616010150 TPR repeat; Region: TPR_11; pfam13414 391616010151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010152 binding surface 391616010153 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391616010154 TPR motif; other site 391616010155 TPR repeat; Region: TPR_11; pfam13414 391616010156 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 391616010157 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 391616010158 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391616010159 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391616010160 substrate binding pocket [chemical binding]; other site 391616010161 chain length determination region; other site 391616010162 substrate-Mg2+ binding site; other site 391616010163 catalytic residues [active] 391616010164 aspartate-rich region 1; other site 391616010165 active site lid residues [active] 391616010166 aspartate-rich region 2; other site 391616010167 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 391616010168 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391616010169 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616010170 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616010171 Integrase core domain; Region: rve; pfam00665 391616010172 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 391616010173 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391616010174 NAD(P) binding site [chemical binding]; other site 391616010175 homotetramer interface [polypeptide binding]; other site 391616010176 homodimer interface [polypeptide binding]; other site 391616010177 active site 391616010178 putative acyltransferase; Provisional; Region: PRK05790 391616010179 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391616010180 dimer interface [polypeptide binding]; other site 391616010181 active site 391616010182 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391616010183 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 391616010184 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391616010185 MoaE homodimer interface [polypeptide binding]; other site 391616010186 MoaD interaction [polypeptide binding]; other site 391616010187 active site residues [active] 391616010188 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 391616010189 MoaE interaction surface [polypeptide binding]; other site 391616010190 MoeB interaction surface [polypeptide binding]; other site 391616010191 thiocarboxylated glycine; other site 391616010192 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391616010193 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616010194 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616010195 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391616010196 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391616010197 GIY-YIG motif/motif A; other site 391616010198 active site 391616010199 catalytic site [active] 391616010200 putative DNA binding site [nucleotide binding]; other site 391616010201 metal binding site [ion binding]; metal-binding site 391616010202 UvrB/uvrC motif; Region: UVR; pfam02151 391616010203 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391616010204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616010205 short chain dehydrogenase; Provisional; Region: PRK09134 391616010206 NAD(P) binding site [chemical binding]; other site 391616010207 active site 391616010208 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 391616010209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391616010210 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391616010211 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 391616010212 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 391616010213 tandem repeat interface [polypeptide binding]; other site 391616010214 oligomer interface [polypeptide binding]; other site 391616010215 active site residues [active] 391616010216 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391616010217 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391616010218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391616010219 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391616010220 Walker A/P-loop; other site 391616010221 ATP binding site [chemical binding]; other site 391616010222 Q-loop/lid; other site 391616010223 ABC transporter signature motif; other site 391616010224 Walker B; other site 391616010225 D-loop; other site 391616010226 H-loop/switch region; other site 391616010227 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 391616010228 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 391616010229 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 391616010230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616010231 Transposase; Region: HTH_Tnp_1; cl17663 391616010232 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616010233 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616010234 Protein of unknown function, DUF; Region: DUF411; cl01142 391616010235 Cytochrome c; Region: Cytochrom_C; pfam00034 391616010236 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 391616010237 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 391616010238 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 391616010239 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 391616010240 active site 391616010241 metal binding site [ion binding]; metal-binding site 391616010242 interdomain interaction site; other site 391616010243 hypothetical protein; Validated; Region: PRK07078 391616010244 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010245 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391616010246 active site 391616010247 DNA binding site [nucleotide binding] 391616010248 Int/Topo IB signature motif; other site 391616010249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010250 binding surface 391616010251 TPR motif; other site 391616010252 TPR repeat; Region: TPR_11; pfam13414 391616010253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010254 binding surface 391616010255 TPR motif; other site 391616010256 TPR repeat; Region: TPR_11; pfam13414 391616010257 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 391616010258 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391616010259 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010260 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 391616010261 active site 391616010262 Int/Topo IB signature motif; other site 391616010263 DNA binding site [nucleotide binding] 391616010264 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616010265 EamA-like transporter family; Region: EamA; pfam00892 391616010266 EamA-like transporter family; Region: EamA; pfam00892 391616010267 Domain of unknown function (DUF897); Region: DUF897; cl01312 391616010268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616010269 putative substrate translocation pore; other site 391616010270 photolyase PhrII; Region: phr2; TIGR00591 391616010271 DNA photolyase; Region: DNA_photolyase; pfam00875 391616010272 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 391616010273 Predicted transcriptional regulator [Transcription]; Region: COG2378 391616010274 WYL domain; Region: WYL; pfam13280 391616010275 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010276 active site 391616010277 Int/Topo IB signature motif; other site 391616010278 DNA binding site [nucleotide binding] 391616010279 VRR-NUC domain; Region: VRR_NUC; pfam08774 391616010280 Helix-turn-helix domain; Region: HTH_36; pfam13730 391616010281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616010282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616010283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391616010284 dimerization interface [polypeptide binding]; other site 391616010285 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616010286 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616010287 N-terminal domain interface [polypeptide binding]; other site 391616010288 hypothetical protein; Provisional; Region: PRK07236 391616010289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616010290 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391616010291 NAD(P) binding site [chemical binding]; other site 391616010292 active site 391616010293 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 391616010294 putative catalytic residues [active] 391616010295 MAPEG family; Region: MAPEG; pfam01124 391616010296 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391616010297 hypothetical protein; Provisional; Region: PRK07236 391616010298 hypothetical protein; Provisional; Region: PRK07236 391616010299 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391616010300 Catalytic site [active] 391616010301 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 391616010302 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 391616010303 active site 391616010304 DNA binding site [nucleotide binding] 391616010305 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391616010306 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 391616010307 ParB-like nuclease domain; Region: ParBc; pfam02195 391616010308 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391616010309 DNA methylase; Region: N6_N4_Mtase; pfam01555 391616010310 Protein of unknown function (DUF3489); Region: DUF3489; pfam11994 391616010311 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 391616010312 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 391616010313 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 391616010314 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 391616010315 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 391616010316 tandem repeat interface [polypeptide binding]; other site 391616010317 oligomer interface [polypeptide binding]; other site 391616010318 active site residues [active] 391616010319 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 391616010320 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 391616010321 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 391616010322 Putative phage tail protein; Region: Phage-tail_3; pfam13550 391616010323 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 391616010324 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 391616010325 TIGR02594 family protein; Region: TIGR02594 391616010326 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391616010327 Phage tail repeat like; Region: PTR; pfam12789 391616010328 Winged helix-turn helix; Region: HTH_29; pfam13551 391616010329 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616010330 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391616010331 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616010332 active site 391616010333 metal binding site [ion binding]; metal-binding site 391616010334 hexamer interface [polypeptide binding]; other site 391616010335 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391616010336 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616010337 active site 391616010338 metal binding site [ion binding]; metal-binding site 391616010339 hexamer interface [polypeptide binding]; other site 391616010340 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616010341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616010342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616010343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010344 dimer interface [polypeptide binding]; other site 391616010345 conserved gate region; other site 391616010346 putative PBP binding loops; other site 391616010347 ABC-ATPase subunit interface; other site 391616010348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616010349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010350 putative PBP binding loops; other site 391616010351 ABC-ATPase subunit interface; other site 391616010352 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616010353 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616010354 Walker A/P-loop; other site 391616010355 ATP binding site [chemical binding]; other site 391616010356 Q-loop/lid; other site 391616010357 ABC transporter signature motif; other site 391616010358 Walker B; other site 391616010359 D-loop; other site 391616010360 H-loop/switch region; other site 391616010361 TOBE domain; Region: TOBE_2; pfam08402 391616010362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616010363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616010364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391616010365 dimerization interface [polypeptide binding]; other site 391616010366 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 391616010367 active site 391616010368 catalytic site [active] 391616010369 substrate binding site [chemical binding]; other site 391616010370 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 391616010371 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616010372 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391616010373 putative C-terminal domain interface [polypeptide binding]; other site 391616010374 putative GSH binding site (G-site) [chemical binding]; other site 391616010375 putative dimer interface [polypeptide binding]; other site 391616010376 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 391616010377 putative N-terminal domain interface [polypeptide binding]; other site 391616010378 putative dimer interface [polypeptide binding]; other site 391616010379 putative substrate binding pocket (H-site) [chemical binding]; other site 391616010380 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616010381 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391616010382 [2Fe-2S] cluster binding site [ion binding]; other site 391616010383 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391616010384 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391616010385 FMN-binding pocket [chemical binding]; other site 391616010386 flavin binding motif; other site 391616010387 phosphate binding motif [ion binding]; other site 391616010388 beta-alpha-beta structure motif; other site 391616010389 NAD binding pocket [chemical binding]; other site 391616010390 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616010391 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391616010392 catalytic loop [active] 391616010393 iron binding site [ion binding]; other site 391616010394 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616010395 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391616010396 hydrophobic ligand binding site; other site 391616010397 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616010398 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616010399 TM-ABC transporter signature motif; other site 391616010400 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616010401 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391616010402 TM-ABC transporter signature motif; other site 391616010403 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391616010404 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616010405 Walker A/P-loop; other site 391616010406 ATP binding site [chemical binding]; other site 391616010407 Q-loop/lid; other site 391616010408 ABC transporter signature motif; other site 391616010409 Walker B; other site 391616010410 D-loop; other site 391616010411 H-loop/switch region; other site 391616010412 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616010413 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391616010414 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616010415 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616010416 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391616010417 [2Fe-2S] cluster binding site [ion binding]; other site 391616010418 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 391616010419 hydrophobic ligand binding site; other site 391616010420 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391616010421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616010422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616010423 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616010424 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616010425 Putative transposase; Region: Y2_Tnp; pfam04986 391616010426 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616010427 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010428 active site 391616010429 DNA binding site [nucleotide binding] 391616010430 Int/Topo IB signature motif; other site 391616010431 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616010432 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616010433 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616010434 Ion transport protein; Region: Ion_trans; pfam00520 391616010435 Ion channel; Region: Ion_trans_2; pfam07885 391616010436 VRR-NUC domain; Region: VRR_NUC; cl17748 391616010437 Helix-turn-helix domain; Region: HTH_17; pfam12728 391616010438 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010439 active site 391616010440 Int/Topo IB signature motif; other site 391616010441 DNA binding site [nucleotide binding] 391616010442 Predicted transcriptional regulator [Transcription]; Region: COG2378 391616010443 WYL domain; Region: WYL; pfam13280 391616010444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391616010445 dimerization interface [polypeptide binding]; other site 391616010446 putative DNA binding site [nucleotide binding]; other site 391616010447 putative Zn2+ binding site [ion binding]; other site 391616010448 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391616010449 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391616010450 active site 391616010451 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391616010452 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 391616010453 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391616010454 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 391616010455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391616010456 motif II; other site 391616010457 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391616010458 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616010459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616010460 active site 391616010461 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 391616010462 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391616010463 active site 391616010464 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 391616010465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616010466 Walker A/P-loop; other site 391616010467 ATP binding site [chemical binding]; other site 391616010468 Q-loop/lid; other site 391616010469 ABC transporter signature motif; other site 391616010470 Walker B; other site 391616010471 D-loop; other site 391616010472 H-loop/switch region; other site 391616010473 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 391616010474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616010475 Walker A/P-loop; other site 391616010476 ATP binding site [chemical binding]; other site 391616010477 Q-loop/lid; other site 391616010478 ABC transporter signature motif; other site 391616010479 Walker B; other site 391616010480 D-loop; other site 391616010481 H-loop/switch region; other site 391616010482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391616010483 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 391616010484 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 391616010485 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 391616010486 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 391616010487 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616010488 DNA-binding site [nucleotide binding]; DNA binding site 391616010489 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 391616010490 UTRA domain; Region: UTRA; pfam07702 391616010491 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 391616010492 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391616010493 trimer interface [polypeptide binding]; other site 391616010494 active site 391616010495 substrate binding site [chemical binding]; other site 391616010496 CoA binding site [chemical binding]; other site 391616010497 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391616010498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010499 dimer interface [polypeptide binding]; other site 391616010500 conserved gate region; other site 391616010501 ABC-ATPase subunit interface; other site 391616010502 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391616010503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010504 dimer interface [polypeptide binding]; other site 391616010505 conserved gate region; other site 391616010506 putative PBP binding loops; other site 391616010507 ABC-ATPase subunit interface; other site 391616010508 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391616010509 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 391616010510 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 391616010511 Walker A/P-loop; other site 391616010512 ATP binding site [chemical binding]; other site 391616010513 Q-loop/lid; other site 391616010514 ABC transporter signature motif; other site 391616010515 Walker B; other site 391616010516 D-loop; other site 391616010517 H-loop/switch region; other site 391616010518 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616010519 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010520 active site 391616010521 DNA binding site [nucleotide binding] 391616010522 Int/Topo IB signature motif; other site 391616010523 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616010524 Putative transposase; Region: Y2_Tnp; pfam04986 391616010525 Fic family protein [Function unknown]; Region: COG3177 391616010526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616010527 MULE transposase domain; Region: MULE; pfam10551 391616010528 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391616010529 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 391616010530 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616010531 rhamnulokinase; Provisional; Region: rhaB; PRK10640 391616010532 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 391616010533 active site 391616010534 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 391616010535 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391616010536 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 391616010537 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391616010538 Pseudomonas aeruginosa PA3087 and related proteins, metallophosphatase domain; Region: MPP_PA3087; cd07413 391616010539 active site 391616010540 metal binding site [ion binding]; metal-binding site 391616010541 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391616010542 synthetase active site [active] 391616010543 NTP binding site [chemical binding]; other site 391616010544 metal binding site [ion binding]; metal-binding site 391616010545 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391616010546 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 391616010547 Protein of unknown function (DUF983); Region: DUF983; cl02211 391616010548 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616010549 MULE transposase domain; Region: MULE; pfam10551 391616010550 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391616010551 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 391616010552 active site 391616010553 metal binding site [ion binding]; metal-binding site 391616010554 Predicted transcriptional regulator [Transcription]; Region: COG2378 391616010555 WYL domain; Region: WYL; pfam13280 391616010556 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616010557 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616010558 Walker A motif; other site 391616010559 ATP binding site [chemical binding]; other site 391616010560 Walker B motif; other site 391616010561 arginine finger; other site 391616010562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616010563 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616010564 Walker A motif; other site 391616010565 ATP binding site [chemical binding]; other site 391616010566 Walker B motif; other site 391616010567 arginine finger; other site 391616010568 Exonuclease I [DNA replication, recombination, and repair]; Region: SbcB; COG2925 391616010569 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 391616010570 active site 391616010571 catalytic site [active] 391616010572 substrate binding site [chemical binding]; other site 391616010573 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 391616010574 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 391616010575 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 391616010576 putative ADP-ribose binding site [chemical binding]; other site 391616010577 putative active site [active] 391616010578 Uncharacterized conserved protein [Function unknown]; Region: COG1479 391616010579 Protein of unknown function DUF262; Region: DUF262; pfam03235 391616010580 Protein of unknown function DUF262; Region: DUF262; pfam03235 391616010581 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 391616010582 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616010583 MULE transposase domain; Region: MULE; pfam10551 391616010584 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 391616010585 dimer interface [polypeptide binding]; other site 391616010586 substrate binding site [chemical binding]; other site 391616010587 ATP binding site [chemical binding]; other site 391616010588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616010589 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391616010590 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391616010591 thiS-thiF/thiG interaction site; other site 391616010592 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391616010593 ThiS interaction site; other site 391616010594 putative active site [active] 391616010595 tetramer interface [polypeptide binding]; other site 391616010596 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391616010597 active site 391616010598 thiamine phosphate binding site [chemical binding]; other site 391616010599 pyrophosphate binding site [ion binding]; other site 391616010600 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391616010601 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 391616010602 ATP binding site [chemical binding]; other site 391616010603 substrate interface [chemical binding]; other site 391616010604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391616010605 NMT1/THI5 like; Region: NMT1; pfam09084 391616010606 Putative transcription activator [Transcription]; Region: TenA; COG0819 391616010607 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391616010608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616010609 Walker A/P-loop; other site 391616010610 ATP binding site [chemical binding]; other site 391616010611 Q-loop/lid; other site 391616010612 ABC transporter signature motif; other site 391616010613 Walker B; other site 391616010614 D-loop; other site 391616010615 H-loop/switch region; other site 391616010616 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 391616010617 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616010618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010619 dimer interface [polypeptide binding]; other site 391616010620 conserved gate region; other site 391616010621 putative PBP binding loops; other site 391616010622 ABC-ATPase subunit interface; other site 391616010623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616010624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391616010625 NAD(P) binding site [chemical binding]; other site 391616010626 active site 391616010627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616010628 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391616010629 NAD(P) binding site [chemical binding]; other site 391616010630 active site 391616010631 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 391616010632 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 391616010633 N- and C-terminal domain interface [polypeptide binding]; other site 391616010634 active site 391616010635 MgATP binding site [chemical binding]; other site 391616010636 catalytic site [active] 391616010637 metal binding site [ion binding]; metal-binding site 391616010638 putative carbohydrate binding site [chemical binding]; other site 391616010639 putative homodimer interface [polypeptide binding]; other site 391616010640 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 391616010641 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 391616010642 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616010643 E3 interaction surface; other site 391616010644 lipoyl attachment site [posttranslational modification]; other site 391616010645 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391616010646 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391616010647 alpha subunit interface [polypeptide binding]; other site 391616010648 TPP binding site [chemical binding]; other site 391616010649 heterodimer interface [polypeptide binding]; other site 391616010650 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616010651 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391616010652 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391616010653 tetramer interface [polypeptide binding]; other site 391616010654 TPP-binding site [chemical binding]; other site 391616010655 heterodimer interface [polypeptide binding]; other site 391616010656 phosphorylation loop region [posttranslational modification] 391616010657 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616010658 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616010659 TM-ABC transporter signature motif; other site 391616010660 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616010661 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616010662 Walker A/P-loop; other site 391616010663 ATP binding site [chemical binding]; other site 391616010664 Q-loop/lid; other site 391616010665 ABC transporter signature motif; other site 391616010666 Walker B; other site 391616010667 D-loop; other site 391616010668 H-loop/switch region; other site 391616010669 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616010670 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616010671 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616010672 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391616010673 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391616010674 riboflavin synthase subunit beta; Provisional; Region: PRK12419 391616010675 active site 391616010676 homopentamer interface [polypeptide binding]; other site 391616010677 SURF4 family; Region: SURF4; pfam02077 391616010678 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 391616010679 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 391616010680 CDGSH-type zinc finger. Function unknown; Region: ZnF_CDGSH; smart00704 391616010681 Pirin; Region: Pirin; pfam02678 391616010682 Pirin-related protein [General function prediction only]; Region: COG1741 391616010683 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 391616010684 transcriptional regulator, ArgP family; Region: argP; TIGR03298 391616010685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616010686 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616010687 putative effector binding pocket; other site 391616010688 dimerization interface [polypeptide binding]; other site 391616010689 Isochorismatase family; Region: Isochorismatase; pfam00857 391616010690 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 391616010691 catalytic triad [active] 391616010692 conserved cis-peptide bond; other site 391616010693 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616010694 Integrase core domain; Region: rve; pfam00665 391616010695 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616010696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616010697 Walker A motif; other site 391616010698 ATP binding site [chemical binding]; other site 391616010699 Walker B motif; other site 391616010700 arginine finger; other site 391616010701 VRR-NUC domain; Region: VRR_NUC; cl17748 391616010702 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616010703 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616010704 Putative transposase; Region: Y2_Tnp; pfam04986 391616010705 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616010706 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010707 active site 391616010708 DNA binding site [nucleotide binding] 391616010709 Int/Topo IB signature motif; other site 391616010710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616010711 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391616010712 dimer interface [polypeptide binding]; other site 391616010713 phosphorylation site [posttranslational modification] 391616010714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616010715 ATP binding site [chemical binding]; other site 391616010716 Mg2+ binding site [ion binding]; other site 391616010717 G-X-G motif; other site 391616010718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391616010719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616010720 active site 391616010721 phosphorylation site [posttranslational modification] 391616010722 intermolecular recognition site; other site 391616010723 dimerization interface [polypeptide binding]; other site 391616010724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616010725 DNA binding site [nucleotide binding] 391616010726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616010727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616010728 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391616010729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010730 putative PBP binding loops; other site 391616010731 dimer interface [polypeptide binding]; other site 391616010732 ABC-ATPase subunit interface; other site 391616010733 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616010734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616010735 dimer interface [polypeptide binding]; other site 391616010736 conserved gate region; other site 391616010737 putative PBP binding loops; other site 391616010738 ABC-ATPase subunit interface; other site 391616010739 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391616010740 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616010741 Walker A/P-loop; other site 391616010742 ATP binding site [chemical binding]; other site 391616010743 Q-loop/lid; other site 391616010744 ABC transporter signature motif; other site 391616010745 Walker B; other site 391616010746 D-loop; other site 391616010747 H-loop/switch region; other site 391616010748 Glucokinase; Region: Glucokinase; cl17310 391616010749 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616010750 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616010751 active site 391616010752 DNA binding site [nucleotide binding] 391616010753 Int/Topo IB signature motif; other site 391616010754 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616010755 Putative transposase; Region: Y2_Tnp; pfam04986 391616010756 MULE transposase domain; Region: MULE; pfam10551 391616010757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616010758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616010759 putative substrate translocation pore; other site 391616010760 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 391616010761 TMAO/DMSO reductase; Reviewed; Region: PRK05363 391616010762 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391616010763 Moco binding site; other site 391616010764 metal coordination site [ion binding]; other site 391616010765 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 391616010766 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391616010767 active site 391616010768 FMN binding site [chemical binding]; other site 391616010769 substrate binding site [chemical binding]; other site 391616010770 3Fe-4S cluster binding site [ion binding]; other site 391616010771 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391616010772 Fasciclin domain; Region: Fasciclin; pfam02469 391616010773 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391616010774 Clp amino terminal domain; Region: Clp_N; pfam02861 391616010775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616010776 Walker A motif; other site 391616010777 ATP binding site [chemical binding]; other site 391616010778 Walker B motif; other site 391616010779 arginine finger; other site 391616010780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616010781 Walker A motif; other site 391616010782 ATP binding site [chemical binding]; other site 391616010783 Walker B motif; other site 391616010784 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391616010785 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 391616010786 active site 391616010787 dimer interface [polypeptide binding]; other site 391616010788 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391616010789 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391616010790 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 391616010791 nudix motif; other site 391616010792 DNA polymerase IV; Provisional; Region: PRK02794 391616010793 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391616010794 active site 391616010795 DNA binding site [nucleotide binding] 391616010796 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 391616010797 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 391616010798 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 391616010799 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 391616010800 malonyl-CoA binding site [chemical binding]; other site 391616010801 dimer interface [polypeptide binding]; other site 391616010802 active site 391616010803 product binding site; other site 391616010804 Phospholipid methyltransferase; Region: PEMT; cl17370 391616010805 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616010806 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 391616010807 active site 391616010808 ligand binding site [chemical binding]; other site 391616010809 homodimer interface [polypeptide binding]; other site 391616010810 NAD(P) binding site [chemical binding]; other site 391616010811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616010812 short chain dehydrogenase; Provisional; Region: PRK07024 391616010813 NAD(P) binding site [chemical binding]; other site 391616010814 active site 391616010815 MFS/sugar transport protein; Region: MFS_2; pfam13347 391616010816 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 391616010817 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 391616010818 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616010819 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 391616010820 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 391616010821 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616010822 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616010823 DNA binding residues [nucleotide binding] 391616010824 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 391616010825 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391616010826 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616010827 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 391616010828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616010829 ATP binding site [chemical binding]; other site 391616010830 Mg2+ binding site [ion binding]; other site 391616010831 G-X-G motif; other site 391616010832 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 391616010833 ATP binding site [chemical binding]; other site 391616010834 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 391616010835 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391616010836 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391616010837 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391616010838 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391616010839 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391616010840 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391616010841 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 391616010842 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 391616010843 lipoprotein signal peptidase; Provisional; Region: PRK14787 391616010844 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391616010845 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391616010846 purine monophosphate binding site [chemical binding]; other site 391616010847 dimer interface [polypeptide binding]; other site 391616010848 putative catalytic residues [active] 391616010849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 391616010850 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 391616010851 NusB family; Region: NusB; pfam01029 391616010852 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 391616010853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616010854 S-adenosylmethionine binding site [chemical binding]; other site 391616010855 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 391616010856 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 391616010857 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391616010858 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 391616010859 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391616010860 Predicted periplasmic protein [Function unknown]; Region: COG3698 391616010861 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 391616010862 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 391616010863 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 391616010864 RNA binding site [nucleotide binding]; other site 391616010865 active site 391616010866 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391616010867 active site 391616010868 metal binding site [ion binding]; metal-binding site 391616010869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616010870 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 391616010871 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616010872 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 391616010873 16S/18S rRNA binding site [nucleotide binding]; other site 391616010874 S13e-L30e interaction site [polypeptide binding]; other site 391616010875 25S rRNA binding site [nucleotide binding]; other site 391616010876 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 391616010877 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 391616010878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391616010879 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 391616010880 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 391616010881 RNase E interface [polypeptide binding]; other site 391616010882 trimer interface [polypeptide binding]; other site 391616010883 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391616010884 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 391616010885 RNase E interface [polypeptide binding]; other site 391616010886 trimer interface [polypeptide binding]; other site 391616010887 active site 391616010888 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391616010889 putative nucleic acid binding region [nucleotide binding]; other site 391616010890 G-X-X-G motif; other site 391616010891 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 391616010892 RNA binding site [nucleotide binding]; other site 391616010893 domain interface; other site 391616010894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391616010895 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391616010896 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616010897 putative peroxiredoxin; Provisional; Region: PRK13190 391616010898 Winged helix-turn helix; Region: HTH_29; pfam13551 391616010899 Winged helix-turn helix; Region: HTH_33; pfam13592 391616010900 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616010901 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616010902 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391616010903 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391616010904 active site 391616010905 Predicted permeases [General function prediction only]; Region: RarD; COG2962 391616010906 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616010907 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616010908 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616010909 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391616010910 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616010911 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 391616010912 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391616010913 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616010914 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616010915 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391616010916 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391616010917 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391616010918 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391616010919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616010920 non-specific DNA binding site [nucleotide binding]; other site 391616010921 salt bridge; other site 391616010922 sequence-specific DNA binding site [nucleotide binding]; other site 391616010923 Cupin domain; Region: Cupin_2; cl17218 391616010924 Cupin domain; Region: Cupin_2; pfam07883 391616010925 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 391616010926 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391616010927 dimer interface [polypeptide binding]; other site 391616010928 active site 391616010929 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616010930 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616010931 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391616010932 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391616010933 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 391616010934 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391616010935 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391616010936 catalytic residue [active] 391616010937 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 391616010938 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 391616010939 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 391616010940 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 391616010941 TrkA-N domain; Region: TrkA_N; pfam02254 391616010942 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 391616010943 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391616010944 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391616010945 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 391616010946 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 391616010947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616010948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616010949 homodimer interface [polypeptide binding]; other site 391616010950 catalytic residue [active] 391616010951 hypothetical protein; Provisional; Region: PRK06102 391616010952 Amidase; Region: Amidase; cl11426 391616010953 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391616010954 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 391616010955 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 391616010956 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391616010957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391616010958 catalytic residues [active] 391616010959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616010960 binding surface 391616010961 TPR motif; other site 391616010962 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391616010963 putative catalytic site [active] 391616010964 putative phosphate binding site [ion binding]; other site 391616010965 active site 391616010966 metal binding site A [ion binding]; metal-binding site 391616010967 DNA binding site [nucleotide binding] 391616010968 putative AP binding site [nucleotide binding]; other site 391616010969 putative metal binding site B [ion binding]; other site 391616010970 transaminase; Validated; Region: PRK07324 391616010971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391616010972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616010973 homodimer interface [polypeptide binding]; other site 391616010974 catalytic residue [active] 391616010975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391616010976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616010977 active site 391616010978 phosphorylation site [posttranslational modification] 391616010979 intermolecular recognition site; other site 391616010980 dimerization interface [polypeptide binding]; other site 391616010981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616010982 DNA binding site [nucleotide binding] 391616010983 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 391616010984 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391616010985 dimerization interface [polypeptide binding]; other site 391616010986 active site 391616010987 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391616010988 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 391616010989 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 391616010990 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391616010991 catalytic residue [active] 391616010992 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616010993 MULE transposase domain; Region: MULE; pfam10551 391616010994 Integrase core domain; Region: rve; pfam00665 391616010995 Integrase core domain; Region: rve_3; pfam13683 391616010996 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 391616010997 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 391616010998 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 391616010999 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 391616011000 HIGH motif; other site 391616011001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391616011002 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616011003 active site 391616011004 KMSKS motif; other site 391616011005 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391616011006 tRNA binding surface [nucleotide binding]; other site 391616011007 Lipopolysaccharide-assembly; Region: LptE; pfam04390 391616011008 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 391616011009 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 391616011010 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011011 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011012 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011014 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011015 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011016 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391616011017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616011018 active site 391616011019 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391616011020 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 391616011021 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391616011022 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391616011023 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391616011024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391616011025 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 391616011026 putative NAD(P) binding site [chemical binding]; other site 391616011027 active site 391616011028 putative substrate binding site [chemical binding]; other site 391616011029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616011030 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 391616011031 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391616011032 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391616011033 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616011034 substrate binding site [chemical binding]; other site 391616011035 oxyanion hole (OAH) forming residues; other site 391616011036 trimer interface [polypeptide binding]; other site 391616011037 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391616011038 classical (c) SDRs; Region: SDR_c; cd05233 391616011039 NAD(P) binding site [chemical binding]; other site 391616011040 active site 391616011041 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391616011042 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391616011043 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391616011044 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391616011045 active site 391616011046 Domain of unknown function (DUF4170); Region: DUF4170; pfam13773 391616011047 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391616011048 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 391616011049 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 391616011050 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391616011051 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391616011052 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391616011053 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 391616011054 catalytic residues [active] 391616011055 Protein of unknown function (DUF721); Region: DUF721; pfam05258 391616011056 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391616011057 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391616011058 minor groove reading motif; other site 391616011059 helix-hairpin-helix signature motif; other site 391616011060 substrate binding pocket [chemical binding]; other site 391616011061 active site 391616011062 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391616011063 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 391616011064 DNA binding and oxoG recognition site [nucleotide binding] 391616011065 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 391616011066 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391616011067 NAD binding site [chemical binding]; other site 391616011068 homodimer interface [polypeptide binding]; other site 391616011069 active site 391616011070 substrate binding site [chemical binding]; other site 391616011071 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391616011072 DNA methylase; Region: N6_N4_Mtase; pfam01555 391616011073 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391616011074 RNA/DNA hybrid binding site [nucleotide binding]; other site 391616011075 active site 391616011076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 391616011077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616011078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616011079 DNA binding site [nucleotide binding] 391616011080 domain linker motif; other site 391616011081 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391616011082 putative dimerization interface [polypeptide binding]; other site 391616011083 putative ligand binding site [chemical binding]; other site 391616011084 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616011085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616011086 Walker A motif; other site 391616011087 ATP binding site [chemical binding]; other site 391616011088 Walker B motif; other site 391616011089 arginine finger; other site 391616011090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616011091 Integrase core domain; Region: rve; pfam00665 391616011092 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616011093 Sel1-like repeats; Region: SEL1; smart00671 391616011094 Sel1-like repeats; Region: SEL1; smart00671 391616011095 Sel1-like repeats; Region: SEL1; smart00671 391616011096 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616011097 Sel1-like repeats; Region: SEL1; smart00671 391616011098 Sel1-like repeats; Region: SEL1; smart00671 391616011099 Sel1-like repeats; Region: SEL1; smart00671 391616011100 Sel1-like repeats; Region: SEL1; smart00671 391616011101 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616011102 Sel1-like repeats; Region: SEL1; smart00671 391616011103 Sel1-like repeats; Region: SEL1; smart00671 391616011104 Sel1-like repeats; Region: SEL1; smart00671 391616011105 Sel1-like repeats; Region: SEL1; smart00671 391616011106 Sel1-like repeats; Region: SEL1; smart00671 391616011107 Sel1-like repeats; Region: SEL1; smart00671 391616011108 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616011109 Sel1-like repeats; Region: SEL1; smart00671 391616011110 Sel1 repeat; Region: Sel1; cl02723 391616011111 Sel1 repeat; Region: Sel1; cl02723 391616011112 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 391616011113 HemY protein N-terminus; Region: HemY_N; pfam07219 391616011114 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 391616011115 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391616011116 active site 391616011117 UGMP family protein; Validated; Region: PRK09604 391616011118 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391616011119 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391616011120 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391616011121 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391616011122 EVE domain; Region: EVE; cl00728 391616011123 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011124 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011125 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011126 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011127 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 391616011128 Uncharacterized protein conserved in bacteria (DUF2333); Region: DUF2333; cl11978 391616011129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616011130 Walker B; other site 391616011131 D-loop; other site 391616011132 H-loop/switch region; other site 391616011133 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011134 Fic family protein [Function unknown]; Region: COG3177 391616011135 Fic/DOC family; Region: Fic; pfam02661 391616011136 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 391616011137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616011138 Walker A motif; other site 391616011139 ATP binding site [chemical binding]; other site 391616011140 Walker B motif; other site 391616011141 arginine finger; other site 391616011142 Nuclease-related domain; Region: NERD; pfam08378 391616011143 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011144 Integrase core domain; Region: rve; pfam00665 391616011145 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 391616011146 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 391616011147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616011148 Transposase; Region: HTH_Tnp_1; cl17663 391616011149 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011150 Sodium Bile acid symporter family; Region: SBF; cl17470 391616011151 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011152 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616011153 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 391616011154 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391616011155 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391616011156 homotetramer interface [polypeptide binding]; other site 391616011157 ligand binding site [chemical binding]; other site 391616011158 catalytic site [active] 391616011159 NAD binding site [chemical binding]; other site 391616011160 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 391616011161 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391616011162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616011163 The C-terminal substrate-binding domain of LysR-type transcriptional regulator HvrB, an activator of S-adenosyl-L-homocysteine hydrolase expression, contains the type 2 periplasmic binding fold; Region: PBP2_HvrB; cd08483 391616011164 putative dimerization interface [polypeptide binding]; other site 391616011165 putative substrate binding pocket [chemical binding]; other site 391616011166 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391616011167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616011168 active site 391616011169 phosphorylation site [posttranslational modification] 391616011170 intermolecular recognition site; other site 391616011171 dimerization interface [polypeptide binding]; other site 391616011172 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391616011173 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391616011174 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391616011175 Cu(I) binding site [ion binding]; other site 391616011176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391616011177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616011178 dimer interface [polypeptide binding]; other site 391616011179 phosphorylation site [posttranslational modification] 391616011180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616011181 ATP binding site [chemical binding]; other site 391616011182 Mg2+ binding site [ion binding]; other site 391616011183 G-X-G motif; other site 391616011184 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616011185 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011186 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391616011187 allantoate amidohydrolase; Reviewed; Region: PRK12893 391616011188 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391616011189 active site 391616011190 metal binding site [ion binding]; metal-binding site 391616011191 dimer interface [polypeptide binding]; other site 391616011192 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616011193 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616011194 TM-ABC transporter signature motif; other site 391616011195 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616011196 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616011197 Walker A/P-loop; other site 391616011198 ATP binding site [chemical binding]; other site 391616011199 Q-loop/lid; other site 391616011200 ABC transporter signature motif; other site 391616011201 Walker B; other site 391616011202 D-loop; other site 391616011203 H-loop/switch region; other site 391616011204 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616011205 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616011206 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391616011207 ligand binding site [chemical binding]; other site 391616011208 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 391616011209 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 391616011210 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391616011211 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391616011212 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391616011213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391616011214 MarR family; Region: MarR_2; pfam12802 391616011215 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 391616011216 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616011217 ligand binding site [chemical binding]; other site 391616011218 dimerization interface [polypeptide binding]; other site 391616011219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616011220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616011221 TM-ABC transporter signature motif; other site 391616011222 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616011223 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616011224 Walker A/P-loop; other site 391616011225 ATP binding site [chemical binding]; other site 391616011226 Q-loop/lid; other site 391616011227 ABC transporter signature motif; other site 391616011228 Walker B; other site 391616011229 D-loop; other site 391616011230 H-loop/switch region; other site 391616011231 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616011232 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 391616011233 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391616011234 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 391616011235 putative N- and C-terminal domain interface [polypeptide binding]; other site 391616011236 putative active site [active] 391616011237 MgATP binding site [chemical binding]; other site 391616011238 catalytic site [active] 391616011239 metal binding site [ion binding]; metal-binding site 391616011240 putative xylulose binding site [chemical binding]; other site 391616011241 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 391616011242 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391616011243 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391616011244 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391616011245 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391616011246 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 391616011247 intersubunit interface [polypeptide binding]; other site 391616011248 active site 391616011249 zinc binding site [ion binding]; other site 391616011250 Na+ binding site [ion binding]; other site 391616011251 fructose-1,6-bisphosphatase; Provisional; Region: PRK09293 391616011252 active site 391616011253 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391616011254 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 391616011255 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391616011256 triosephosphate isomerase; Provisional; Region: PRK14565 391616011257 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391616011258 substrate binding site [chemical binding]; other site 391616011259 dimer interface [polypeptide binding]; other site 391616011260 catalytic triad [active] 391616011261 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 391616011262 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 391616011263 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 391616011264 putative N- and C-terminal domain interface [polypeptide binding]; other site 391616011265 putative active site [active] 391616011266 MgATP binding site [chemical binding]; other site 391616011267 catalytic site [active] 391616011268 metal binding site [ion binding]; metal-binding site 391616011269 putative xylulose binding site [chemical binding]; other site 391616011270 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391616011271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616011272 Integrase core domain; Region: rve; pfam00665 391616011273 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 391616011274 active site 391616011275 homopentamer interface [polypeptide binding]; other site 391616011276 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616011277 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616011278 Integrase core domain; Region: rve; pfam00665 391616011279 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011280 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391616011281 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616011282 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391616011283 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616011284 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616011285 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391616011286 dihydroxyacetone kinase; Provisional; Region: PRK14479 391616011287 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 391616011288 DAK2 domain; Region: Dak2; cl03685 391616011289 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616011290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011291 Fic family protein [Function unknown]; Region: COG3177 391616011292 Fic/DOC family; Region: Fic; pfam02661 391616011293 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 391616011294 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616011295 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011296 Integrase core domain; Region: rve; pfam00665 391616011297 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616011298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011299 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011300 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011301 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391616011302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391616011303 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391616011304 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391616011305 intersubunit interface [polypeptide binding]; other site 391616011306 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391616011307 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391616011308 metal binding site 2 [ion binding]; metal-binding site 391616011309 putative DNA binding helix; other site 391616011310 metal binding site 1 [ion binding]; metal-binding site 391616011311 dimer interface [polypeptide binding]; other site 391616011312 structural Zn2+ binding site [ion binding]; other site 391616011313 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 391616011314 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391616011315 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391616011316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391616011317 ABC-ATPase subunit interface; other site 391616011318 dimer interface [polypeptide binding]; other site 391616011319 putative PBP binding regions; other site 391616011320 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616011321 Putative transposase; Region: Y2_Tnp; pfam04986 391616011322 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616011323 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616011324 active site 391616011325 DNA binding site [nucleotide binding] 391616011326 Int/Topo IB signature motif; other site 391616011327 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 391616011328 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616011329 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391616011330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 391616011331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616011332 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011333 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011334 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391616011335 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 391616011336 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391616011337 putative acyl-acceptor binding pocket; other site 391616011338 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 391616011339 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 391616011340 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391616011341 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391616011342 DNA binding residues [nucleotide binding] 391616011343 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391616011344 dimer interface [polypeptide binding]; other site 391616011345 putative metal binding site [ion binding]; other site 391616011346 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 391616011347 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391616011348 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011349 MULE transposase domain; Region: MULE; pfam10551 391616011350 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 391616011351 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391616011352 dimer interface [polypeptide binding]; other site 391616011353 active site 391616011354 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 391616011355 acyl-activating enzyme (AAE) consensus motif; other site 391616011356 AMP binding site [chemical binding]; other site 391616011357 active site 391616011358 CoA binding site [chemical binding]; other site 391616011359 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 391616011360 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 391616011361 putative FMN binding site [chemical binding]; other site 391616011362 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391616011363 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391616011364 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391616011365 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391616011366 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391616011367 catalytic loop [active] 391616011368 iron binding site [ion binding]; other site 391616011369 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391616011370 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391616011371 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391616011372 BioY family; Region: BioY; pfam02632 391616011373 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 391616011374 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 391616011375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 391616011376 Walker A/P-loop; other site 391616011377 ATP binding site [chemical binding]; other site 391616011378 Q-loop/lid; other site 391616011379 ABC transporter signature motif; other site 391616011380 Walker B; other site 391616011381 D-loop; other site 391616011382 H-loop/switch region; other site 391616011383 succinic semialdehyde dehydrogenase; Region: PLN02278 391616011384 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391616011385 tetramerization interface [polypeptide binding]; other site 391616011386 NAD(P) binding site [chemical binding]; other site 391616011387 catalytic residues [active] 391616011388 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 391616011389 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616011390 inhibitor-cofactor binding pocket; inhibition site 391616011391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616011392 catalytic residue [active] 391616011393 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616011394 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616011395 TM-ABC transporter signature motif; other site 391616011396 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616011397 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616011398 Walker A/P-loop; other site 391616011399 ATP binding site [chemical binding]; other site 391616011400 Q-loop/lid; other site 391616011401 ABC transporter signature motif; other site 391616011402 Walker B; other site 391616011403 D-loop; other site 391616011404 H-loop/switch region; other site 391616011405 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616011406 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 391616011407 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 391616011408 putative ligand binding site [chemical binding]; other site 391616011409 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 391616011410 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 391616011411 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 391616011412 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391616011413 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391616011414 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391616011415 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391616011416 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391616011417 carboxyltransferase (CT) interaction site; other site 391616011418 biotinylation site [posttranslational modification]; other site 391616011419 hypothetical protein; Provisional; Region: PRK12569 391616011420 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616011421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616011422 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 391616011423 putative substrate binding pocket [chemical binding]; other site 391616011424 dimerization interface [polypeptide binding]; other site 391616011425 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616011426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011427 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616011428 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011429 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011430 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011431 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011432 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011433 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616011434 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616011435 TM-ABC transporter signature motif; other site 391616011436 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616011437 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616011438 Walker A/P-loop; other site 391616011439 ATP binding site [chemical binding]; other site 391616011440 Q-loop/lid; other site 391616011441 ABC transporter signature motif; other site 391616011442 Walker B; other site 391616011443 D-loop; other site 391616011444 H-loop/switch region; other site 391616011445 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616011446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391616011447 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616011448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391616011449 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616011450 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011451 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011452 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011453 Transposase; Region: HTH_Tnp_1; pfam01527 391616011454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616011455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616011456 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616011457 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011459 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011460 Homeodomain-like domain; Region: HTH_32; pfam13565 391616011461 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616011463 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011464 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011465 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616011466 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616011467 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391616011468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391616011469 motif II; other site 391616011470 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011471 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391616011472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 391616011473 DNA binding residues [nucleotide binding] 391616011474 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391616011475 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 391616011476 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391616011477 intersubunit interface [polypeptide binding]; other site 391616011478 active site 391616011479 zinc binding site [ion binding]; other site 391616011480 Na+ binding site [ion binding]; other site 391616011481 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 391616011482 AMP binding site [chemical binding]; other site 391616011483 metal binding site [ion binding]; metal-binding site 391616011484 active site 391616011485 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391616011486 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 391616011487 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616011488 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616011489 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 391616011490 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391616011491 E3 interaction surface; other site 391616011492 lipoyl attachment site [posttranslational modification]; other site 391616011493 e3 binding domain; Region: E3_binding; pfam02817 391616011494 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391616011495 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391616011496 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391616011497 alpha subunit interface [polypeptide binding]; other site 391616011498 TPP binding site [chemical binding]; other site 391616011499 heterodimer interface [polypeptide binding]; other site 391616011500 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616011501 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 391616011502 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391616011503 tetramer interface [polypeptide binding]; other site 391616011504 TPP-binding site [chemical binding]; other site 391616011505 heterodimer interface [polypeptide binding]; other site 391616011506 phosphorylation loop region [posttranslational modification] 391616011507 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 391616011508 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616011509 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 391616011510 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 391616011511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616011512 Walker A/P-loop; other site 391616011513 ATP binding site [chemical binding]; other site 391616011514 Q-loop/lid; other site 391616011515 ABC transporter signature motif; other site 391616011516 Walker B; other site 391616011517 D-loop; other site 391616011518 H-loop/switch region; other site 391616011519 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616011520 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391616011521 substrate binding site [chemical binding]; other site 391616011522 ATP binding site [chemical binding]; other site 391616011523 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616011524 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011525 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616011526 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011527 MULE transposase domain; Region: MULE; pfam10551 391616011528 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011529 Homeodomain-like domain; Region: HTH_32; pfam13565 391616011530 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011531 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011533 Homeodomain-like domain; Region: HTH_23; pfam13384 391616011534 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011535 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011536 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011538 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616011539 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391616011540 substrate binding site [chemical binding]; other site 391616011541 ATP binding site [chemical binding]; other site 391616011542 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391616011543 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 391616011544 putative NAD(P) binding site [chemical binding]; other site 391616011545 catalytic Zn binding site [ion binding]; other site 391616011546 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 391616011547 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 391616011548 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 391616011549 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391616011550 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616011551 TM-ABC transporter signature motif; other site 391616011552 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391616011553 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391616011554 Walker A/P-loop; other site 391616011555 ATP binding site [chemical binding]; other site 391616011556 Q-loop/lid; other site 391616011557 ABC transporter signature motif; other site 391616011558 Walker B; other site 391616011559 D-loop; other site 391616011560 H-loop/switch region; other site 391616011561 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391616011562 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391616011563 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391616011564 ligand binding site [chemical binding]; other site 391616011565 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011566 MULE transposase domain; Region: MULE; pfam10551 391616011567 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391616011568 Initiator Replication protein; Region: Rep_3; pfam01051 391616011569 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011570 MULE transposase domain; Region: MULE; pfam10551 391616011571 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011572 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011573 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616011574 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616011575 Integrase core domain; Region: rve; pfam00665 391616011576 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 391616011577 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 391616011578 putative active site [active] 391616011579 putative NTP binding site [chemical binding]; other site 391616011580 putative nucleic acid binding site [nucleotide binding]; other site 391616011581 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011582 MULE transposase domain; Region: MULE; pfam10551 391616011583 Autotransporter beta-domain; Region: Autotransporter; cl17461 391616011584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616011585 Integrase core domain; Region: rve; pfam00665 391616011586 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616011587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616011588 Walker A motif; other site 391616011589 ATP binding site [chemical binding]; other site 391616011590 Walker B motif; other site 391616011591 arginine finger; other site 391616011592 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616011593 MULE transposase domain; Region: MULE; pfam10551 391616011594 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616011595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616011596 Walker A motif; other site 391616011597 ATP binding site [chemical binding]; other site 391616011598 Walker B motif; other site 391616011599 arginine finger; other site 391616011600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616011601 Integrase core domain; Region: rve; pfam00665 391616011602 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391616011603 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 391616011604 active site 391616011605 dimer interface [polypeptide binding]; other site 391616011606 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391616011607 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391616011608 active site 391616011609 FMN binding site [chemical binding]; other site 391616011610 substrate binding site [chemical binding]; other site 391616011611 3Fe-4S cluster binding site [ion binding]; other site 391616011612 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391616011613 domain interface; other site 391616011614 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391616011615 Bacitracin resistance protein BacA; Region: BacA; pfam02673 391616011616 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391616011617 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 391616011618 putative NAD(P) binding site [chemical binding]; other site 391616011619 active site 391616011620 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391616011621 HSP70 interaction site [polypeptide binding]; other site 391616011622 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 391616011623 Toprim domain; Region: Toprim_3; pfam13362 391616011624 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616011625 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011626 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011627 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616011628 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616011629 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011630 Integrase core domain; Region: rve; pfam00665 391616011631 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391616011632 hypothetical protein; Provisional; Region: PRK07036 391616011633 inhibitor-cofactor binding pocket; inhibition site 391616011634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616011635 catalytic residue [active] 391616011636 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391616011637 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 391616011638 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616011639 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616011640 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391616011641 [2Fe-2S] cluster binding site [ion binding]; other site 391616011642 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391616011643 alpha subunit interface [polypeptide binding]; other site 391616011644 active site 391616011645 substrate binding site [chemical binding]; other site 391616011646 Fe binding site [ion binding]; other site 391616011647 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 391616011648 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616011649 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391616011650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616011651 Walker A/P-loop; other site 391616011652 ATP binding site [chemical binding]; other site 391616011653 Q-loop/lid; other site 391616011654 ABC transporter signature motif; other site 391616011655 Walker B; other site 391616011656 D-loop; other site 391616011657 H-loop/switch region; other site 391616011658 TOBE domain; Region: TOBE; pfam03459 391616011659 TOBE domain; Region: TOBE_2; pfam08402 391616011660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616011661 dimer interface [polypeptide binding]; other site 391616011662 conserved gate region; other site 391616011663 putative PBP binding loops; other site 391616011664 ABC-ATPase subunit interface; other site 391616011665 sulfate transport protein; Provisional; Region: cysT; CHL00187 391616011666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616011667 dimer interface [polypeptide binding]; other site 391616011668 conserved gate region; other site 391616011669 putative PBP binding loops; other site 391616011670 ABC-ATPase subunit interface; other site 391616011671 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 391616011672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616011673 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391616011674 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616011676 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616011677 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616011678 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616011679 Integrase core domain; Region: rve; pfam00665 391616011680 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 391616011681 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 391616011682 Ligand binding site; other site 391616011683 oligomer interface; other site 391616011684 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391616011685 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391616011686 active site 391616011687 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391616011688 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391616011689 Bacterial SH3 domain; Region: SH3_3; pfam08239 391616011690 Predicted membrane protein [Function unknown]; Region: COG3650 391616011691 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011692 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011693 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011694 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011695 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 391616011696 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 391616011697 Phosphotransferase enzyme family; Region: APH; pfam01636 391616011698 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391616011699 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 391616011700 Substrate binding site; other site 391616011701 metal-binding site 391616011702 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 391616011703 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391616011704 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 391616011705 Part of AAA domain; Region: AAA_19; pfam13245 391616011706 Family description; Region: UvrD_C_2; pfam13538 391616011707 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391616011708 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391616011709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391616011710 catalytic residues [active] 391616011711 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 391616011712 active site 391616011713 HslU subunit interaction site [polypeptide binding]; other site 391616011714 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 391616011715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616011716 Walker A motif; other site 391616011717 ATP binding site [chemical binding]; other site 391616011718 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 391616011719 Walker B motif; other site 391616011720 arginine finger; other site 391616011721 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391616011722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391616011723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391616011724 putative substrate translocation pore; other site 391616011725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 391616011726 Smr domain; Region: Smr; pfam01713 391616011727 MltA specific insert domain; Region: MltA; smart00925 391616011728 3D domain; Region: 3D; pfam06725 391616011729 Tim44-like domain; Region: Tim44; pfam04280 391616011730 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 391616011731 Preprotein translocase subunit SecB; Region: SecB; pfam02556 391616011732 SecA binding site; other site 391616011733 Preprotein binding site; other site 391616011734 Transposase; Region: HTH_Tnp_1; pfam01527 391616011735 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011736 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011737 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011738 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011739 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 391616011740 active site 391616011741 catalytic site [active] 391616011742 substrate binding site [chemical binding]; other site 391616011743 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 391616011744 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391616011745 CoA-binding site [chemical binding]; other site 391616011746 ATP-binding [chemical binding]; other site 391616011747 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391616011748 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391616011749 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391616011750 shikimate binding site; other site 391616011751 NAD(P) binding site [chemical binding]; other site 391616011752 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391616011753 active site 391616011754 dimer interface [polypeptide binding]; other site 391616011755 transcription termination factor Rho; Provisional; Region: rho; PRK09376 391616011756 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 391616011757 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 391616011758 RNA binding site [nucleotide binding]; other site 391616011759 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 391616011760 multimer interface [polypeptide binding]; other site 391616011761 Walker A motif; other site 391616011762 ATP binding site [chemical binding]; other site 391616011763 Walker B motif; other site 391616011764 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 391616011765 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 391616011766 trmE is a tRNA modification GTPase; Region: trmE; cd04164 391616011767 G1 box; other site 391616011768 GTP/Mg2+ binding site [chemical binding]; other site 391616011769 Switch I region; other site 391616011770 G2 box; other site 391616011771 Switch II region; other site 391616011772 G3 box; other site 391616011773 G4 box; other site 391616011774 G5 box; other site 391616011775 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 391616011776 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 391616011777 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616011778 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391616011779 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 391616011780 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 391616011781 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 391616011782 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391616011783 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391616011784 Magnesium ion binding site [ion binding]; other site 391616011785 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391616011786 ParB-like nuclease domain; Region: ParBc; pfam02195 391616011787 Helix-turn-helix; Region: HTH_3; pfam01381 391616011788 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 391616011789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616011790 FeS/SAM binding site; other site 391616011791 HemN C-terminal domain; Region: HemN_C; pfam06969 391616011792 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 391616011793 active site 391616011794 dimerization interface [polypeptide binding]; other site 391616011795 ribonuclease PH; Reviewed; Region: rph; PRK00173 391616011796 Ribonuclease PH; Region: RNase_PH_bact; cd11362 391616011797 hexamer interface [polypeptide binding]; other site 391616011798 active site 391616011799 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391616011800 GrpE; Region: GrpE; pfam01025 391616011801 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 391616011802 dimer interface [polypeptide binding]; other site 391616011803 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391616011804 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 391616011805 MutS domain I; Region: MutS_I; pfam01624 391616011806 MutS domain II; Region: MutS_II; pfam05188 391616011807 MutS domain III; Region: MutS_III; pfam05192 391616011808 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 391616011809 Walker A/P-loop; other site 391616011810 ATP binding site [chemical binding]; other site 391616011811 Q-loop/lid; other site 391616011812 ABC transporter signature motif; other site 391616011813 Walker B; other site 391616011814 D-loop; other site 391616011815 H-loop/switch region; other site 391616011816 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 391616011817 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391616011818 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391616011819 putative NAD(P) binding site [chemical binding]; other site 391616011820 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391616011821 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391616011822 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391616011823 substrate binding site [chemical binding]; other site 391616011824 dimer interface [polypeptide binding]; other site 391616011825 ATP binding site [chemical binding]; other site 391616011826 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 391616011827 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011828 Integrase core domain; Region: rve; pfam00665 391616011829 Integrase core domain; Region: rve_3; pfam13683 391616011830 argininosuccinate synthase; Provisional; Region: PRK13820 391616011831 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 391616011832 ANP binding site [chemical binding]; other site 391616011833 Substrate Binding Site II [chemical binding]; other site 391616011834 Substrate Binding Site I [chemical binding]; other site 391616011835 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 391616011836 nudix motif; other site 391616011837 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 391616011838 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 391616011839 dimerization interface [polypeptide binding]; other site 391616011840 domain crossover interface; other site 391616011841 redox-dependent activation switch; other site 391616011842 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391616011843 putative active site [active] 391616011844 putative CoA binding site [chemical binding]; other site 391616011845 nudix motif; other site 391616011846 metal binding site [ion binding]; metal-binding site 391616011847 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 391616011848 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391616011849 active site 391616011850 NTP binding site [chemical binding]; other site 391616011851 metal binding triad [ion binding]; metal-binding site 391616011852 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391616011853 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616011854 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616011855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616011856 Walker A/P-loop; other site 391616011857 ATP binding site [chemical binding]; other site 391616011858 Q-loop/lid; other site 391616011859 ABC transporter signature motif; other site 391616011860 Walker B; other site 391616011861 D-loop; other site 391616011862 H-loop/switch region; other site 391616011863 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391616011864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391616011865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616011866 Walker A/P-loop; other site 391616011867 ATP binding site [chemical binding]; other site 391616011868 Q-loop/lid; other site 391616011869 ABC transporter signature motif; other site 391616011870 Walker B; other site 391616011871 D-loop; other site 391616011872 H-loop/switch region; other site 391616011873 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 391616011874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616011875 S-adenosylmethionine binding site [chemical binding]; other site 391616011876 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391616011877 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391616011878 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616011879 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616011880 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616011881 ferrochelatase; Reviewed; Region: hemH; PRK00035 391616011882 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391616011883 C-terminal domain interface [polypeptide binding]; other site 391616011884 active site 391616011885 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391616011886 active site 391616011887 N-terminal domain interface [polypeptide binding]; other site 391616011888 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391616011889 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391616011890 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 391616011891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391616011892 active site 391616011893 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391616011894 putative active site [active] 391616011895 catalytic triad [active] 391616011896 dimer interface [polypeptide binding]; other site 391616011897 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391616011898 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616011899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616011900 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616011901 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391616011902 Methyltransferase domain; Region: Methyltransf_11; pfam08241 391616011903 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 391616011904 TAP-like protein; Region: Abhydrolase_4; pfam08386 391616011905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391616011906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616011907 dimer interface [polypeptide binding]; other site 391616011908 conserved gate region; other site 391616011909 ABC-ATPase subunit interface; other site 391616011910 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 391616011911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616011912 dimer interface [polypeptide binding]; other site 391616011913 conserved gate region; other site 391616011914 putative PBP binding loops; other site 391616011915 ABC-ATPase subunit interface; other site 391616011916 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391616011917 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616011918 Walker A/P-loop; other site 391616011919 ATP binding site [chemical binding]; other site 391616011920 Q-loop/lid; other site 391616011921 ABC transporter signature motif; other site 391616011922 Walker B; other site 391616011923 D-loop; other site 391616011924 H-loop/switch region; other site 391616011925 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391616011926 Walker A/P-loop; other site 391616011927 ATP binding site [chemical binding]; other site 391616011928 Q-loop/lid; other site 391616011929 ABC transporter signature motif; other site 391616011930 Walker B; other site 391616011931 D-loop; other site 391616011932 H-loop/switch region; other site 391616011933 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391616011934 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391616011935 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391616011936 ribosome maturation protein RimP; Reviewed; Region: PRK00092 391616011937 Sm and related proteins; Region: Sm_like; cl00259 391616011938 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 391616011939 putative oligomer interface [polypeptide binding]; other site 391616011940 putative RNA binding site [nucleotide binding]; other site 391616011941 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 391616011942 NusA N-terminal domain; Region: NusA_N; pfam08529 391616011943 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 391616011944 RNA binding site [nucleotide binding]; other site 391616011945 homodimer interface [polypeptide binding]; other site 391616011946 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391616011947 G-X-X-G motif; other site 391616011948 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391616011949 G-X-X-G motif; other site 391616011950 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391616011951 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391616011952 hypothetical protein; Provisional; Region: PRK09190 391616011953 Protein of unknown function (DUF448); Region: DUF448; pfam04296 391616011954 putative RNA binding cleft [nucleotide binding]; other site 391616011955 translation initiation factor IF-2; Region: IF-2; TIGR00487 391616011956 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391616011957 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 391616011958 G1 box; other site 391616011959 putative GEF interaction site [polypeptide binding]; other site 391616011960 GTP/Mg2+ binding site [chemical binding]; other site 391616011961 Switch I region; other site 391616011962 G2 box; other site 391616011963 G3 box; other site 391616011964 Switch II region; other site 391616011965 G4 box; other site 391616011966 G5 box; other site 391616011967 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 391616011968 Translation-initiation factor 2; Region: IF-2; pfam11987 391616011969 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 391616011970 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391616011971 active site 391616011972 8-oxo-dGMP binding site [chemical binding]; other site 391616011973 nudix motif; other site 391616011974 metal binding site [ion binding]; metal-binding site 391616011975 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 391616011976 heterotetramer interface [polypeptide binding]; other site 391616011977 active site pocket [active] 391616011978 cleavage site 391616011979 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 391616011980 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391616011981 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 391616011982 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391616011983 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 391616011984 nucleotide binding region [chemical binding]; other site 391616011985 ATP-binding site [chemical binding]; other site 391616011986 SEC-C motif; Region: SEC-C; pfam02810 391616011987 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616011988 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616011989 Integrase core domain; Region: rve; pfam00665 391616011990 Winged helix-turn helix; Region: HTH_29; pfam13551 391616011991 Winged helix-turn helix; Region: HTH_33; pfam13592 391616011992 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011994 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616011995 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616011996 hypothetical protein; Reviewed; Region: PRK00024 391616011997 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391616011998 MPN+ (JAMM) motif; other site 391616011999 Zinc-binding site [ion binding]; other site 391616012000 chaperone protein DnaJ; Provisional; Region: PRK10767 391616012001 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391616012002 HSP70 interaction site [polypeptide binding]; other site 391616012003 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 391616012004 substrate binding site [polypeptide binding]; other site 391616012005 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391616012006 Zn binding sites [ion binding]; other site 391616012007 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391616012008 dimer interface [polypeptide binding]; other site 391616012009 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391616012010 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391616012011 nucleotide binding site [chemical binding]; other site 391616012012 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 391616012013 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616012014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012015 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616012016 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 391616012017 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012018 MULE transposase domain; Region: MULE; pfam10551 391616012019 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 391616012020 classical (c) SDRs; Region: SDR_c; cd05233 391616012021 NAD(P) binding site [chemical binding]; other site 391616012022 active site 391616012023 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 391616012024 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616012025 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616012026 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391616012027 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616012028 NAD binding site [chemical binding]; other site 391616012029 catalytic residues [active] 391616012030 hypothetical protein; Provisional; Region: PRK07490 391616012031 intersubunit interface [polypeptide binding]; other site 391616012032 active site 391616012033 Zn2+ binding site [ion binding]; other site 391616012034 choline dehydrogenase; Validated; Region: PRK02106 391616012035 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616012036 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391616012037 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391616012038 [2Fe-2S] cluster binding site [ion binding]; other site 391616012039 Ring hydroxylating alpha subunit (catalytic domain); Region: Ring_hydroxyl_A; pfam00848 391616012040 hydrophobic ligand binding site; other site 391616012041 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391616012042 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391616012043 conserved cys residue [active] 391616012044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391616012045 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391616012046 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391616012047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616012048 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391616012049 Walker A/P-loop; other site 391616012050 ATP binding site [chemical binding]; other site 391616012051 Q-loop/lid; other site 391616012052 ABC transporter signature motif; other site 391616012053 Walker B; other site 391616012054 D-loop; other site 391616012055 H-loop/switch region; other site 391616012056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616012057 dimer interface [polypeptide binding]; other site 391616012058 conserved gate region; other site 391616012059 putative PBP binding loops; other site 391616012060 ABC-ATPase subunit interface; other site 391616012061 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391616012062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616012063 dimer interface [polypeptide binding]; other site 391616012064 conserved gate region; other site 391616012065 putative PBP binding loops; other site 391616012066 ABC-ATPase subunit interface; other site 391616012067 replication factor C large subunit; Provisional; Region: PRK04195 391616012068 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616012069 Integrase core domain; Region: rve; pfam00665 391616012070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616012071 Transposase; Region: HTH_Tnp_1; pfam01527 391616012072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391616012073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616012074 catalytic residues [active] 391616012075 catalytic nucleophile [active] 391616012076 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616012077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616012078 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616012079 Synaptic Site I dimer interface [polypeptide binding]; other site 391616012080 DNA binding site [nucleotide binding] 391616012081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616012082 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616012083 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616012084 putative effector binding pocket; other site 391616012085 dimerization interface [polypeptide binding]; other site 391616012086 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391616012087 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391616012088 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391616012089 NAD(P) binding site [chemical binding]; other site 391616012090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616012091 Integrase core domain; Region: rve; pfam00665 391616012092 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616012093 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012094 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 391616012095 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 391616012096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616012097 Walker A motif; other site 391616012098 ATP binding site [chemical binding]; other site 391616012099 Walker B motif; other site 391616012100 Family description; Region: UvrD_C_2; pfam13538 391616012101 DNA topoisomerase III; Provisional; Region: PRK07726 391616012102 TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli...; Region: TOPRIM_TopoIA; cd01028 391616012103 active site 391616012104 interdomain interaction site; other site 391616012105 putative metal-binding site [ion binding]; other site 391616012106 nucleotide binding site [chemical binding]; other site 391616012107 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 391616012108 domain I; other site 391616012109 DNA binding groove [nucleotide binding] 391616012110 phosphate binding site [ion binding]; other site 391616012111 domain II; other site 391616012112 domain III; other site 391616012113 nucleotide binding site [chemical binding]; other site 391616012114 catalytic site [active] 391616012115 domain IV; other site 391616012116 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 391616012117 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616012118 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012119 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012120 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012121 Integrase core domain; Region: rve; pfam00665 391616012122 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012123 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616012124 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616012125 active site 391616012126 catalytic tetrad [active] 391616012127 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616012128 Integrase core domain; Region: rve; pfam00665 391616012129 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391616012130 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 391616012131 HlyD family secretion protein; Region: HlyD_3; pfam13437 391616012132 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616012133 Putative transposase; Region: Y2_Tnp; pfam04986 391616012134 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616012135 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616012136 active site 391616012137 DNA binding site [nucleotide binding] 391616012138 Int/Topo IB signature motif; other site 391616012139 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616012140 EamA-like transporter family; Region: EamA; pfam00892 391616012141 EamA-like transporter family; Region: EamA; pfam00892 391616012142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616012143 Walker A motif; other site 391616012144 ATP binding site [chemical binding]; other site 391616012145 Walker B motif; other site 391616012146 arginine finger; other site 391616012147 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012148 MULE transposase domain; Region: MULE; pfam10551 391616012149 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012150 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391616012151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616012152 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012153 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012154 Integrase core domain; Region: rve; pfam00665 391616012155 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 391616012156 ligand binding site; other site 391616012157 tetramer interface; other site 391616012158 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 391616012159 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391616012160 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391616012161 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391616012162 pseudaminic acid synthase; Region: PseI; TIGR03586 391616012163 NeuB family; Region: NeuB; pfam03102 391616012164 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 391616012165 NeuB binding interface [polypeptide binding]; other site 391616012166 putative substrate binding site [chemical binding]; other site 391616012167 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 391616012168 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012169 MULE transposase domain; Region: MULE; pfam10551 391616012170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012171 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391616012172 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391616012173 inhibitor-cofactor binding pocket; inhibition site 391616012174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616012175 catalytic residue [active] 391616012176 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 391616012177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616012178 NAD(P) binding site [chemical binding]; other site 391616012179 active site 391616012180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616012181 Walker A motif; other site 391616012182 ATP binding site [chemical binding]; other site 391616012183 Walker B motif; other site 391616012184 arginine finger; other site 391616012185 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012186 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391616012187 DNA binding residues [nucleotide binding] 391616012188 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 391616012189 dimer interface [polypeptide binding]; other site 391616012190 putative metal binding site [ion binding]; other site 391616012191 MerT mercuric transport protein; Region: MerT; cl03578 391616012192 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391616012193 metal-binding site [ion binding] 391616012194 Membrane transport protein MerF; Region: Transport_MerF; pfam11431 391616012195 mercuric reductase; Region: MerA; TIGR02053 391616012196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391616012197 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616012198 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391616012199 Transposase; Region: HTH_Tnp_1; cl17663 391616012200 Integrase core domain; Region: rve; pfam00665 391616012201 Integrase core domain; Region: rve_3; pfam13683 391616012202 Transposase; Region: HTH_Tnp_1; cl17663 391616012203 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616012204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616012205 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616012206 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012207 Predicted membrane protein [Function unknown]; Region: COG2364 391616012208 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 391616012209 CcdB protein; Region: CcdB; cl03380 391616012210 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012211 Integrase core domain; Region: rve; pfam00665 391616012212 Integrase core domain; Region: rve_3; pfam13683 391616012213 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391616012214 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391616012215 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391616012216 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391616012217 NAD(P) binding site [chemical binding]; other site 391616012218 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 391616012219 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 391616012220 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 391616012221 active site 391616012222 Fe binding site [ion binding]; other site 391616012223 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 391616012224 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391616012225 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616012226 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616012227 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616012228 DctM-like transporters; Region: DctM; pfam06808 391616012229 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616012230 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616012231 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 391616012232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012233 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391616012234 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391616012235 Sulfatase; Region: Sulfatase; cl17466 391616012236 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616012237 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616012238 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616012239 N-terminal domain interface [polypeptide binding]; other site 391616012240 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391616012241 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 391616012242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391616012243 ATP binding site [chemical binding]; other site 391616012244 putative Mg++ binding site [ion binding]; other site 391616012245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391616012246 nucleotide binding region [chemical binding]; other site 391616012247 ATP-binding site [chemical binding]; other site 391616012248 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391616012249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616012250 Integrase core domain; Region: rve; pfam00665 391616012251 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 391616012252 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 391616012253 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 391616012254 DXD motif; other site 391616012255 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 391616012256 Acyltransferase family; Region: Acyl_transf_3; pfam01757 391616012257 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 391616012258 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391616012259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391616012260 ATP binding site [chemical binding]; other site 391616012261 Mg2+ binding site [ion binding]; other site 391616012262 G-X-G motif; other site 391616012263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391616012264 anti sigma factor interaction site; other site 391616012265 regulatory phosphorylation site [posttranslational modification]; other site 391616012266 Response regulator receiver domain; Region: Response_reg; pfam00072 391616012267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616012268 active site 391616012269 phosphorylation site [posttranslational modification] 391616012270 intermolecular recognition site; other site 391616012271 dimerization interface [polypeptide binding]; other site 391616012272 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391616012273 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012274 Winged helix-turn helix; Region: HTH_33; pfam13592 391616012275 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616012276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616012277 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012278 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012279 Integrase core domain; Region: rve; pfam00665 391616012280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391616012281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616012282 active site 391616012283 phosphorylation site [posttranslational modification] 391616012284 intermolecular recognition site; other site 391616012285 dimerization interface [polypeptide binding]; other site 391616012286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391616012287 DNA binding residues [nucleotide binding] 391616012288 dimerization interface [polypeptide binding]; other site 391616012289 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391616012290 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391616012291 active site 391616012292 tetramer interface; other site 391616012293 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391616012294 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391616012295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391616012296 putative active site [active] 391616012297 heme pocket [chemical binding]; other site 391616012298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391616012299 dimer interface [polypeptide binding]; other site 391616012300 phosphorylation site [posttranslational modification] 391616012301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391616012302 ATP binding site [chemical binding]; other site 391616012303 Mg2+ binding site [ion binding]; other site 391616012304 G-X-G motif; other site 391616012305 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391616012306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616012307 active site 391616012308 phosphorylation site [posttranslational modification] 391616012309 intermolecular recognition site; other site 391616012310 dimerization interface [polypeptide binding]; other site 391616012311 Hpt domain; Region: Hpt; pfam01627 391616012312 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012313 MULE transposase domain; Region: MULE; pfam10551 391616012314 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012315 Integrase core domain; Region: rve; pfam00665 391616012316 Integrase core domain; Region: rve_3; pfam13683 391616012317 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012318 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012319 Integrase core domain; Region: rve; pfam00665 391616012320 Integrase core domain; Region: rve; pfam00665 391616012321 Integrase core domain; Region: rve_3; pfam13683 391616012322 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391616012323 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616012324 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616012325 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012326 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616012327 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616012328 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616012329 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616012330 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 391616012331 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391616012332 Presynaptic Site I dimer interface [polypeptide binding]; other site 391616012333 catalytic residues [active] 391616012334 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 391616012335 Synaptic Flat tetramer interface [polypeptide binding]; other site 391616012336 Synaptic Site I dimer interface [polypeptide binding]; other site 391616012337 DNA binding site [nucleotide binding] 391616012338 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 391616012339 DNA-binding interface [nucleotide binding]; DNA binding site 391616012340 Spore Coat Protein U domain; Region: SCPU; cl02253 391616012341 Spore Coat Protein U domain; Region: SCPU; cl02253 391616012342 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 391616012343 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 391616012344 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 391616012345 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 391616012346 PapC C-terminal domain; Region: PapC_C; pfam13953 391616012347 Spore Coat Protein U domain; Region: SCPU; pfam05229 391616012348 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 391616012350 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 391616012351 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012352 Integrase core domain; Region: rve; pfam00665 391616012353 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012354 Winged helix-turn helix; Region: HTH_33; pfam13592 391616012355 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616012356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616012357 Integrase core domain; Region: rve; pfam00665 391616012358 Integrase core domain; Region: rve_3; pfam13683 391616012359 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616012360 Sel1-like repeats; Region: SEL1; smart00671 391616012361 Sel1-like repeats; Region: SEL1; smart00671 391616012362 Sel1-like repeats; Region: SEL1; smart00671 391616012363 Sel1-like repeats; Region: SEL1; smart00671 391616012364 Sel1-like repeats; Region: SEL1; smart00671 391616012365 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391616012366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616012367 active site 391616012368 phosphorylation site [posttranslational modification] 391616012369 intermolecular recognition site; other site 391616012370 dimerization interface [polypeptide binding]; other site 391616012371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391616012372 DNA binding residues [nucleotide binding] 391616012373 dimerization interface [polypeptide binding]; other site 391616012374 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012375 Integrase core domain; Region: rve; pfam00665 391616012376 Integrase core domain; Region: rve_3; pfam13683 391616012377 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 391616012378 Protein of unknown function (DUF736); Region: DUF736; pfam05284 391616012379 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 391616012380 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616012381 Integrase core domain; Region: rve; pfam00665 391616012382 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391616012383 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 391616012384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391616012386 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 391616012387 active site residue [active] 391616012388 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 391616012389 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391616012390 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012391 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012392 Integrase core domain; Region: rve; pfam00665 391616012393 Integrase core domain; Region: rve; pfam00665 391616012394 Integrase core domain; Region: rve_3; pfam13683 391616012395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012396 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616012397 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616012398 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616012399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616012400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616012401 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616012402 Integrase core domain; Region: rve; pfam00665 391616012403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391616012404 Ligand Binding Site [chemical binding]; other site 391616012405 EamA-like transporter family; Region: EamA; pfam00892 391616012406 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616012407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012408 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616012409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616012410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616012411 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391616012412 putative effector binding pocket; other site 391616012413 dimerization interface [polypeptide binding]; other site 391616012414 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012415 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012416 Integrase core domain; Region: rve; pfam00665 391616012417 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616012418 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616012419 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 391616012420 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391616012421 putative acyl-acceptor binding pocket; other site 391616012422 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012423 Helix-turn-helix domain; Region: HTH_28; pfam13518 391616012424 Homeodomain-like domain; Region: HTH_32; pfam13565 391616012425 Integrase core domain; Region: rve; pfam00665 391616012426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391616012427 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391616012428 active site 391616012429 metal binding site [ion binding]; metal-binding site 391616012430 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 391616012431 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 391616012432 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 391616012433 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 391616012434 DNA binding site [nucleotide binding] 391616012435 dimer interface [polypeptide binding]; other site 391616012436 Int/Topo IB signature motif; other site 391616012437 active site 391616012438 Protein of unknown function (DUF1403); Region: DUF1403; pfam07183 391616012439 Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386 391616012440 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391616012441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616012442 Integrase core domain; Region: rve; pfam00665 391616012443 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616012444 Transposase; Region: HTH_Tnp_1; pfam01527 391616012445 HTH-like domain; Region: HTH_21; pfam13276 391616012446 Integrase core domain; Region: rve; pfam00665 391616012447 Integrase core domain; Region: rve_3; pfam13683 391616012448 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012449 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616012450 Hint domain; Region: Hint_2; pfam13403 391616012451 Transglycosylase; Region: Transgly; cl17702 391616012452 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 391616012453 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391616012454 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391616012455 C-terminal domain interface [polypeptide binding]; other site 391616012456 GSH binding site (G-site) [chemical binding]; other site 391616012457 dimer interface [polypeptide binding]; other site 391616012458 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391616012459 N-terminal domain interface [polypeptide binding]; other site 391616012460 dimer interface [polypeptide binding]; other site 391616012461 substrate binding pocket (H-site) [chemical binding]; other site 391616012462 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 391616012463 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 391616012464 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391616012465 EamA-like transporter family; Region: EamA; pfam00892 391616012466 branched-chain amino acid aminotransferase; Validated; Region: PRK07544 391616012467 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391616012468 homodimer interface [polypeptide binding]; other site 391616012469 substrate-cofactor binding pocket; other site 391616012470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616012471 catalytic residue [active] 391616012472 MarR family; Region: MarR_2; pfam12802 391616012473 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391616012474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391616012475 active site 391616012476 phosphorylation site [posttranslational modification] 391616012477 intermolecular recognition site; other site 391616012478 dimerization interface [polypeptide binding]; other site 391616012479 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391616012480 DNA binding site [nucleotide binding] 391616012481 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391616012482 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 391616012483 putative active site [active] 391616012484 Zn binding site [ion binding]; other site 391616012485 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391616012486 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391616012487 substrate binding pocket [chemical binding]; other site 391616012488 chain length determination region; other site 391616012489 substrate-Mg2+ binding site; other site 391616012490 catalytic residues [active] 391616012491 aspartate-rich region 1; other site 391616012492 active site lid residues [active] 391616012493 aspartate-rich region 2; other site 391616012494 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391616012495 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391616012496 TPP-binding site; other site 391616012497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391616012498 PYR/PP interface [polypeptide binding]; other site 391616012499 dimer interface [polypeptide binding]; other site 391616012500 TPP binding site [chemical binding]; other site 391616012501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391616012502 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 391616012503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391616012504 putative NAD(P) binding site [chemical binding]; other site 391616012505 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012506 Homeodomain-like domain; Region: HTH_32; pfam13565 391616012507 Winged helix-turn helix; Region: HTH_33; pfam13592 391616012508 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012509 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 391616012510 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 391616012511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616012512 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391616012513 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616012514 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391616012515 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391616012516 active site 391616012517 trimer interface [polypeptide binding]; other site 391616012518 dimer interface [polypeptide binding]; other site 391616012519 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 391616012520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616012521 substrate binding site [chemical binding]; other site 391616012522 oxyanion hole (OAH) forming residues; other site 391616012523 trimer interface [polypeptide binding]; other site 391616012524 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391616012525 CoA binding domain; Region: CoA_binding_2; pfam13380 391616012526 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 391616012527 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 391616012528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391616012529 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391616012530 active site 391616012531 hypothetical protein; Provisional; Region: PRK07490 391616012532 intersubunit interface [polypeptide binding]; other site 391616012533 active site 391616012534 Zn2+ binding site [ion binding]; other site 391616012535 AMP nucleosidase; Provisional; Region: PRK08292 391616012536 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 391616012537 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 391616012538 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391616012539 IHF dimer interface [polypeptide binding]; other site 391616012540 IHF - DNA interface [nucleotide binding]; other site 391616012541 EamA-like transporter family; Region: EamA; pfam00892 391616012542 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391616012543 EamA-like transporter family; Region: EamA; pfam00892 391616012544 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 391616012545 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391616012546 Tetramer interface [polypeptide binding]; other site 391616012547 active site 391616012548 FMN-binding site [chemical binding]; other site 391616012549 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391616012550 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 391616012551 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 391616012552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616012553 dimer interface [polypeptide binding]; other site 391616012554 conserved gate region; other site 391616012555 putative PBP binding loops; other site 391616012556 ABC-ATPase subunit interface; other site 391616012557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616012558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616012559 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 391616012560 Walker A/P-loop; other site 391616012561 ATP binding site [chemical binding]; other site 391616012562 Q-loop/lid; other site 391616012563 ABC transporter signature motif; other site 391616012564 Walker B; other site 391616012565 D-loop; other site 391616012566 H-loop/switch region; other site 391616012567 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 391616012568 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 391616012569 intrachain domain interface; other site 391616012570 interchain domain interface [polypeptide binding]; other site 391616012571 cytochrome b; Provisional; Region: CYTB; MTH00191 391616012572 heme bH binding site [chemical binding]; other site 391616012573 Qi binding site; other site 391616012574 heme bL binding site [chemical binding]; other site 391616012575 Qo binding site; other site 391616012576 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 391616012577 interchain domain interface [polypeptide binding]; other site 391616012578 intrachain domain interface; other site 391616012579 Qi binding site; other site 391616012580 Qo binding site; other site 391616012581 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391616012582 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391616012583 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391616012584 [2Fe-2S] cluster binding site [ion binding]; other site 391616012585 putative glutathione S-transferase; Provisional; Region: PRK10357 391616012586 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391616012587 putative C-terminal domain interface [polypeptide binding]; other site 391616012588 putative GSH binding site (G-site) [chemical binding]; other site 391616012589 putative dimer interface [polypeptide binding]; other site 391616012590 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 391616012591 dimer interface [polypeptide binding]; other site 391616012592 N-terminal domain interface [polypeptide binding]; other site 391616012593 putative substrate binding pocket (H-site) [chemical binding]; other site 391616012594 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 391616012595 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616012596 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 391616012597 putative N-terminal domain interface [polypeptide binding]; other site 391616012598 putative dimer interface [polypeptide binding]; other site 391616012599 putative substrate binding pocket (H-site) [chemical binding]; other site 391616012600 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 391616012601 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391616012602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391616012603 FeS/SAM binding site; other site 391616012604 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 391616012605 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391616012606 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391616012607 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012608 MULE transposase domain; Region: MULE; pfam10551 391616012609 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616012610 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012611 Integrase core domain; Region: rve; pfam00665 391616012612 Integrase core domain; Region: rve_3; pfam13683 391616012613 Urea transporter; Region: UT; pfam03253 391616012614 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391616012615 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 391616012616 ligand binding site [chemical binding]; other site 391616012617 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391616012618 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391616012619 TM-ABC transporter signature motif; other site 391616012620 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391616012621 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391616012622 TM-ABC transporter signature motif; other site 391616012623 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 391616012624 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391616012625 Walker A/P-loop; other site 391616012626 ATP binding site [chemical binding]; other site 391616012627 Q-loop/lid; other site 391616012628 ABC transporter signature motif; other site 391616012629 Walker B; other site 391616012630 D-loop; other site 391616012631 H-loop/switch region; other site 391616012632 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391616012633 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391616012634 Walker A/P-loop; other site 391616012635 ATP binding site [chemical binding]; other site 391616012636 Q-loop/lid; other site 391616012637 ABC transporter signature motif; other site 391616012638 Walker B; other site 391616012639 D-loop; other site 391616012640 H-loop/switch region; other site 391616012641 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 391616012642 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 391616012643 multimer interface [polypeptide binding]; other site 391616012644 active site 391616012645 catalytic triad [active] 391616012646 dimer interface [polypeptide binding]; other site 391616012647 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 391616012648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616012649 Walker A motif; other site 391616012650 ATP binding site [chemical binding]; other site 391616012651 Walker B motif; other site 391616012652 arginine finger; other site 391616012653 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391616012654 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391616012655 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 391616012656 ligand binding site [chemical binding]; other site 391616012657 regulator interaction site; other site 391616012658 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 391616012659 ANTAR domain; Region: ANTAR; pfam03861 391616012660 acetyl-CoA synthetase; Provisional; Region: PRK00174 391616012661 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391616012662 active site 391616012663 CoA binding site [chemical binding]; other site 391616012664 acyl-activating enzyme (AAE) consensus motif; other site 391616012665 AMP binding site [chemical binding]; other site 391616012666 acetate binding site [chemical binding]; other site 391616012667 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391616012668 hypothetical protein; Provisional; Region: PRK06815 391616012669 tetramer interface [polypeptide binding]; other site 391616012670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391616012671 catalytic residue [active] 391616012672 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012673 MULE transposase domain; Region: MULE; pfam10551 391616012674 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012675 Integrase core domain; Region: rve; pfam00665 391616012676 Integrase core domain; Region: rve_3; pfam13683 391616012677 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391616012678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391616012679 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 391616012680 DctM-like transporters; Region: DctM; pfam06808 391616012681 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391616012682 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391616012683 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391616012684 Sulfatase; Region: Sulfatase; cl17466 391616012685 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391616012686 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391616012687 active site pocket [active] 391616012688 choline dehydrogenase; Validated; Region: PRK02106 391616012689 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616012690 Sulfatase; Region: Sulfatase; cl17466 391616012691 choline-sulfatase; Region: chol_sulfatase; TIGR03417 391616012692 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616012693 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 391616012694 NAD(P) binding site [chemical binding]; other site 391616012695 catalytic residues [active] 391616012696 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 391616012697 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391616012698 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391616012699 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391616012700 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391616012701 active site pocket [active] 391616012702 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391616012703 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616012704 DNA-binding site [nucleotide binding]; DNA binding site 391616012705 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 391616012706 choline dehydrogenase; Validated; Region: PRK02106 391616012707 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616012708 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616012709 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616012710 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391616012711 DctM-like transporters; Region: DctM; pfam06808 391616012712 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616012713 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616012714 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 391616012715 NAD(P) binding site [chemical binding]; other site 391616012716 catalytic residues [active] 391616012717 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 391616012718 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 391616012719 oligomerization interface [polypeptide binding]; other site 391616012720 active site 391616012721 metal binding site [ion binding]; metal-binding site 391616012722 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616012723 Integrase core domain; Region: rve; pfam00665 391616012724 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616012725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616012726 DNA binding site [nucleotide binding] 391616012727 domain linker motif; other site 391616012728 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391616012729 Transposase; Region: HTH_Tnp_1; cl17663 391616012730 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616012731 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391616012732 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616012733 NAD binding site [chemical binding]; other site 391616012734 catalytic residues [active] 391616012735 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391616012736 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391616012737 phosphate binding site [ion binding]; other site 391616012738 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 391616012739 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391616012740 FMN binding site [chemical binding]; other site 391616012741 active site 391616012742 homodimer interface [polypeptide binding]; other site 391616012743 putative catalytic residue [active] 391616012744 4Fe-4S cluster binding site [ion binding]; other site 391616012745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012746 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 391616012747 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391616012748 FMN binding site [chemical binding]; other site 391616012749 active site 391616012750 homodimer interface [polypeptide binding]; other site 391616012751 putative catalytic residue [active] 391616012752 4Fe-4S cluster binding site [ion binding]; other site 391616012753 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012754 Trimethylamine dehydrogenase (TMADH) and histamine dehydrogenase (HD) FMN-binding domain. TMADH is an iron-sulfur flavoprotein that catalyzes the oxidative demethylation of trimethylamine to form dimethylamine and formaldehyde. The protein forms a...; Region: TMADH_HD_FMN; cd02929 391616012755 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391616012756 FMN binding site [chemical binding]; other site 391616012757 active site 391616012758 homodimer interface [polypeptide binding]; other site 391616012759 putative catalytic residue [active] 391616012760 4Fe-4S cluster binding site [ion binding]; other site 391616012761 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391616012762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012763 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 391616012764 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616012765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616012766 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616012767 MULE transposase domain; Region: MULE; pfam10551 391616012768 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616012769 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391616012770 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391616012771 active site 391616012772 tetramer interface; other site 391616012773 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391616012774 active site 391616012775 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391616012776 Transposase; Region: HTH_Tnp_1; pfam01527 391616012777 HTH-like domain; Region: HTH_21; pfam13276 391616012778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 391616012779 Integrase core domain; Region: rve; pfam00665 391616012780 Integrase core domain; Region: rve_3; pfam13683 391616012781 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391616012782 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391616012783 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391616012784 active site 391616012785 phosphorylation site [posttranslational modification] 391616012786 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 391616012787 30S subunit binding site; other site 391616012788 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 391616012789 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 391616012790 Walker A/P-loop; other site 391616012791 ATP binding site [chemical binding]; other site 391616012792 Q-loop/lid; other site 391616012793 ABC transporter signature motif; other site 391616012794 Walker B; other site 391616012795 D-loop; other site 391616012796 H-loop/switch region; other site 391616012797 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 391616012798 OstA-like protein; Region: OstA; pfam03968 391616012799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 391616012800 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 391616012801 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 391616012802 putative active site [active] 391616012803 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 391616012804 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391616012805 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391616012806 catalytic site [active] 391616012807 putative active site [active] 391616012808 putative substrate binding site [chemical binding]; other site 391616012809 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 391616012810 Putative transposase; Region: Y2_Tnp; pfam04986 391616012811 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012812 MULE transposase domain; Region: MULE; pfam10551 391616012813 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012814 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616012815 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616012816 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616012817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012818 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616012819 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616012820 Transposase; Region: HTH_Tnp_1; pfam01527 391616012821 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 391616012822 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616012823 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012824 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616012825 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391616012826 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391616012827 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391616012828 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391616012829 active site 391616012830 catalytic residues [active] 391616012831 DNA binding site [nucleotide binding] 391616012832 Int/Topo IB signature motif; other site 391616012833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012834 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616012835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012836 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616012837 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616012838 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 391616012839 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012840 Homeodomain-like domain; Region: HTH_32; pfam13565 391616012841 Integrase core domain; Region: rve; pfam00665 391616012842 Integrase core domain; Region: rve_3; pfam13683 391616012843 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616012844 Putative transposase; Region: Y2_Tnp; pfam04986 391616012845 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 391616012846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616012847 active site 391616012848 DNA binding site [nucleotide binding] 391616012849 Int/Topo IB signature motif; other site 391616012850 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 391616012851 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 391616012852 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391616012853 substrate binding pocket [chemical binding]; other site 391616012854 substrate-Mg2+ binding site; other site 391616012855 aspartate-rich region 1; other site 391616012856 aspartate-rich region 2; other site 391616012857 phytoene desaturase; Region: crtI_fam; TIGR02734 391616012858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391616012859 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 391616012860 substrate binding pocket [chemical binding]; other site 391616012861 substrate-Mg2+ binding site; other site 391616012862 aspartate-rich region 1; other site 391616012863 aspartate-rich region 2; other site 391616012864 Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834 391616012865 lycopene cyclase; Region: lycopene_cycl; TIGR01789 391616012866 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 391616012867 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012868 MULE transposase domain; Region: MULE; pfam10551 391616012869 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616012870 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616012871 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 391616012872 Putative transposase; Region: Y2_Tnp; pfam04986 391616012873 HTH-like domain; Region: HTH_21; pfam13276 391616012874 Integrase core domain; Region: rve; pfam00665 391616012875 Integrase core domain; Region: rve_3; pfam13683 391616012876 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012877 Winged helix-turn helix; Region: HTH_33; pfam13592 391616012878 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616012879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616012880 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616012881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616012882 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391616012883 histidinol dehydrogenase; Region: hisD; TIGR00069 391616012884 NAD binding site [chemical binding]; other site 391616012885 dimerization interface [polypeptide binding]; other site 391616012886 product binding site; other site 391616012887 substrate binding site [chemical binding]; other site 391616012888 zinc binding site [ion binding]; other site 391616012889 catalytic residues [active] 391616012890 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391616012891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616012892 NAD(P) binding site [chemical binding]; other site 391616012893 active site 391616012894 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391616012895 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391616012896 NAD(P) binding site [chemical binding]; other site 391616012897 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391616012898 PYR/PP interface [polypeptide binding]; other site 391616012899 dimer interface [polypeptide binding]; other site 391616012900 TPP binding site [chemical binding]; other site 391616012901 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 391616012902 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 391616012903 TPP-binding site; other site 391616012904 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391616012905 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391616012906 phosphate binding site [ion binding]; other site 391616012907 methionine sulfoxide reductase B; Provisional; Region: PRK00222 391616012908 SelR domain; Region: SelR; pfam01641 391616012909 methionine sulfoxide reductase A; Provisional; Region: PRK14054 391616012910 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391616012911 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391616012912 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391616012913 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 391616012914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391616012915 Walker A/P-loop; other site 391616012916 ATP binding site [chemical binding]; other site 391616012917 Q-loop/lid; other site 391616012918 ABC transporter signature motif; other site 391616012919 Walker B; other site 391616012920 D-loop; other site 391616012921 H-loop/switch region; other site 391616012922 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 391616012923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616012924 putative PBP binding loops; other site 391616012925 ABC-ATPase subunit interface; other site 391616012926 hypothetical protein; Provisional; Region: PRK11622 391616012927 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 391616012928 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 391616012929 Cytochrome c; Region: Cytochrom_C; cl11414 391616012930 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 391616012931 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 391616012932 active site 391616012933 metal binding site [ion binding]; metal-binding site 391616012934 nudix motif; other site 391616012935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391616012936 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391616012937 dihydroxy-acid dehydratase; Validated; Region: PRK06131 391616012938 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616012939 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012940 Winged helix-turn helix; Region: HTH_33; pfam13592 391616012941 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616012942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616012943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391616012944 TPR motif; other site 391616012945 Tetratricopeptide repeat; Region: TPR_12; pfam13424 391616012946 binding surface 391616012947 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 391616012948 Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387 391616012949 Rod binding protein; Region: Rod-binding; pfam10135 391616012950 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391616012951 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813 391616012952 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391616012953 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391616012954 ABC1 family; Region: ABC1; cl17513 391616012955 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 391616012956 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 391616012957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391616012958 S-adenosylmethionine binding site [chemical binding]; other site 391616012959 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391616012960 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391616012961 DNA binding site [nucleotide binding] 391616012962 catalytic residue [active] 391616012963 H2TH interface [polypeptide binding]; other site 391616012964 putative catalytic residues [active] 391616012965 turnover-facilitating residue; other site 391616012966 intercalation triad [nucleotide binding]; other site 391616012967 8OG recognition residue [nucleotide binding]; other site 391616012968 putative reading head residues; other site 391616012969 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391616012970 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391616012971 enoyl-CoA hydratase; Provisional; Region: PRK05862 391616012972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391616012973 substrate binding site [chemical binding]; other site 391616012974 oxyanion hole (OAH) forming residues; other site 391616012975 trimer interface [polypeptide binding]; other site 391616012976 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 391616012977 Initiator Replication protein; Region: Rep_3; pfam01051 391616012978 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391616012979 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 391616012980 Transposase; Region: HTH_Tnp_1; cl17663 391616012981 Winged helix-turn helix; Region: HTH_29; pfam13551 391616012982 Homeodomain-like domain; Region: HTH_32; pfam13565 391616012983 Integrase core domain; Region: rve; pfam00665 391616012984 Putative transposase; Region: Y2_Tnp; pfam04986 391616012985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616012986 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616012987 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616012988 MULE transposase domain; Region: MULE; pfam10551 391616012989 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 391616012990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616012991 Transposase; Region: HTH_Tnp_1; cl17663 391616012992 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 391616012993 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 391616012994 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 391616012995 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 391616012996 LicD family; Region: LicD; pfam04991 391616012997 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391616012998 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391616012999 active site 391616013000 nucleotide binding site [chemical binding]; other site 391616013001 HIGH motif; other site 391616013002 KMSKS motif; other site 391616013003 flagellin; Provisional; Region: PRK12802 391616013004 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391616013005 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391616013006 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 391616013007 Sel1-like repeats; Region: SEL1; smart00671 391616013008 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 391616013009 SAF-like; Region: SAF_2; pfam13144 391616013010 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391616013011 FimV N-terminal domain; Region: FimV_core; TIGR03505 391616013012 LPP20 lipoprotein; Region: LPP20; pfam02169 391616013013 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 391616013014 FHIPEP family; Region: FHIPEP; pfam00771 391616013015 AAA domain; Region: AAA_17; pfam13207 391616013016 Flagellar protein FliS; Region: FliS; cl00654 391616013017 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 391616013018 FOG: CBS domain [General function prediction only]; Region: COG0517 391616013019 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 391616013020 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 391616013021 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 391616013022 flagellar motor protein MotB; Reviewed; Region: motB; PRK08944 391616013023 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 391616013024 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391616013025 ligand binding site [chemical binding]; other site 391616013026 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391616013027 PhoH-like protein; Region: PhoH; cl17668 391616013028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013029 Walker A motif; other site 391616013030 ATP binding site [chemical binding]; other site 391616013031 Walker B motif; other site 391616013032 arginine finger; other site 391616013033 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 391616013034 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 391616013035 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 391616013036 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 391616013037 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 391616013038 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 391616013039 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 391616013040 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 391616013041 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 391616013042 flagellar biosynthetic protein FliQ; Region: fliQ; TIGR01402 391616013043 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 391616013044 flagellar motor switch protein FliN; Region: fliN; TIGR02480 391616013045 flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397 391616013046 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391616013047 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 391616013048 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 391616013049 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391616013050 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 391616013051 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391616013052 Walker A motif; other site 391616013053 ATP binding site [chemical binding]; other site 391616013054 Walker B motif; other site 391616013055 Flagellar assembly protein FliH; Region: FliH; pfam02108 391616013056 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 391616013057 MgtE intracellular N domain; Region: MgtE_N; smart00924 391616013058 FliG C-terminal domain; Region: FliG_C; pfam01706 391616013059 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 391616013060 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 391616013061 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 391616013062 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 391616013063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013064 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391616013065 Walker A motif; other site 391616013066 ATP binding site [chemical binding]; other site 391616013067 Walker B motif; other site 391616013068 arginine finger; other site 391616013069 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 391616013070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013071 Walker A motif; other site 391616013072 ATP binding site [chemical binding]; other site 391616013073 Walker B motif; other site 391616013074 arginine finger; other site 391616013075 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391616013076 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 391616013077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616013078 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391616013079 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616013080 DNA binding residues [nucleotide binding] 391616013081 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391616013082 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391616013083 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 391616013084 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616013085 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391616013087 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391616013088 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 391616013089 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 391616013090 Cl- selectivity filter; other site 391616013091 Cl- binding residues [ion binding]; other site 391616013092 pore gating glutamate residue; other site 391616013093 dimer interface [polypeptide binding]; other site 391616013094 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 391616013095 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 391616013096 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 391616013097 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 391616013098 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 391616013099 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 391616013100 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391616013101 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391616013102 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391616013103 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391616013104 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391616013105 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391616013106 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391616013107 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 391616013108 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391616013109 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391616013110 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 391616013111 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391616013112 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 391616013113 Flagellar L-ring protein; Region: FlgH; pfam02107 391616013114 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 391616013115 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 391616013116 Rod binding protein; Region: Rod-binding; pfam10135 391616013117 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 391616013118 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391616013119 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391616013120 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391616013121 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 391616013122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391616013123 Peptidase M15; Region: Peptidase_M15_3; cl01194 391616013124 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616013125 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013126 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616013127 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616013128 transposase; Validated; Region: PRK08181 391616013129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013130 Walker A motif; other site 391616013131 ATP binding site [chemical binding]; other site 391616013132 Walker B motif; other site 391616013133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616013134 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616013135 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616013136 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013137 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013138 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013139 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013140 Initiator Replication protein; Region: Rep_3; pfam01051 391616013141 Winged helix-turn helix; Region: HTH_29; pfam13551 391616013142 Homeodomain-like domain; Region: HTH_32; pfam13565 391616013143 Winged helix-turn helix; Region: HTH_33; pfam13592 391616013144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 391616013145 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 391616013146 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 391616013147 PemK-like protein; Region: PemK; pfam02452 391616013148 H-NS histone family; Region: Histone_HNS; pfam00816 391616013149 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391616013150 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 391616013151 HicB family; Region: HicB; pfam05534 391616013152 Winged helix-turn helix; Region: HTH_29; pfam13551 391616013153 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 391616013154 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013155 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616013156 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013157 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 391616013158 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 391616013159 oligomeric interface; other site 391616013160 putative active site [active] 391616013161 homodimer interface [polypeptide binding]; other site 391616013162 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 391616013163 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616013164 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013165 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616013166 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616013167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 391616013168 Transposase; Region: DDE_Tnp_ISL3; pfam01610 391616013169 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 391616013170 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013171 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 391616013172 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 391616013173 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 391616013174 Replication initiator protein A; Region: RPA; pfam10134 391616013175 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391616013176 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391616013177 P-loop; other site 391616013178 Magnesium ion binding site [ion binding]; other site 391616013179 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 391616013180 Helix-turn-helix domain; Region: HTH_37; pfam13744 391616013181 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013182 Integrase core domain; Region: rve; pfam00665 391616013183 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391616013184 Predicted transcriptional regulator [Transcription]; Region: COG3905 391616013185 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616013186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616013187 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013188 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 391616013189 Predicted transcriptional regulator [Transcription]; Region: COG3905 391616013190 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 391616013191 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391616013192 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391616013193 P-loop; other site 391616013194 Magnesium ion binding site [ion binding]; other site 391616013195 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391616013196 ParB-like nuclease domain; Region: ParBc; cl02129 391616013197 Replication protein C N-terminal domain; Region: RP-C; pfam03428 391616013198 Replication protein C C-terminal region; Region: RP-C_C; pfam11800 391616013199 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 391616013200 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 391616013201 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391616013202 active site 391616013203 Int/Topo IB signature motif; other site 391616013204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013205 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013206 Integrase core domain; Region: rve; pfam00665 391616013207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013208 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013209 Integrase core domain; Region: rve; pfam00665 391616013210 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391616013211 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391616013212 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391616013213 putative dimerization interface [polypeptide binding]; other site 391616013214 putative glutathione S-transferase; Provisional; Region: PRK10357 391616013215 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391616013216 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391616013217 dimer interface [polypeptide binding]; other site 391616013218 N-terminal domain interface [polypeptide binding]; other site 391616013219 substrate binding pocket (H-site) [chemical binding]; other site 391616013220 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616013221 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616013222 DctM-like transporters; Region: DctM; pfam06808 391616013223 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616013224 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391616013225 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391616013226 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391616013227 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 391616013228 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 391616013229 Flavin Reductases; Region: FlaRed; cl00801 391616013230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013231 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013232 Integrase core domain; Region: rve; pfam00665 391616013233 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391616013234 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391616013235 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391616013236 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 391616013237 substrate binding site [chemical binding]; other site 391616013238 THF binding site; other site 391616013239 zinc-binding site [ion binding]; other site 391616013240 Cupin domain; Region: Cupin_2; pfam07883 391616013241 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616013242 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616013243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391616013244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391616013245 DNA binding site [nucleotide binding] 391616013246 domain linker motif; other site 391616013247 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391616013248 putative dimerization interface [polypeptide binding]; other site 391616013249 putative ligand binding site [chemical binding]; other site 391616013250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616013251 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 391616013252 NAD(P) binding site [chemical binding]; other site 391616013253 active site 391616013254 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616013255 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616013256 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391616013257 histidinol dehydrogenase; Region: hisD; TIGR00069 391616013258 NAD binding site [chemical binding]; other site 391616013259 dimerization interface [polypeptide binding]; other site 391616013260 product binding site; other site 391616013261 substrate binding site [chemical binding]; other site 391616013262 zinc binding site [ion binding]; other site 391616013263 catalytic residues [active] 391616013264 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391616013265 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616013266 Walker A/P-loop; other site 391616013267 ATP binding site [chemical binding]; other site 391616013268 Q-loop/lid; other site 391616013269 ABC transporter signature motif; other site 391616013270 Walker B; other site 391616013271 D-loop; other site 391616013272 H-loop/switch region; other site 391616013273 SnoaL-like domain; Region: SnoaL_2; pfam12680 391616013274 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616013275 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616013276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616013277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616013278 dimer interface [polypeptide binding]; other site 391616013279 conserved gate region; other site 391616013280 putative PBP binding loops; other site 391616013281 ABC-ATPase subunit interface; other site 391616013282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616013283 dimer interface [polypeptide binding]; other site 391616013284 putative PBP binding loops; other site 391616013285 ABC-ATPase subunit interface; other site 391616013286 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616013287 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391616013288 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013289 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013290 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616013291 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013293 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013294 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013295 Integrase core domain; Region: rve; pfam00665 391616013296 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 391616013297 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 391616013298 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013299 Ferredoxin [Energy production and conversion]; Region: COG1146 391616013300 4Fe-4S binding domain; Region: Fer4; cl02805 391616013301 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391616013302 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391616013303 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391616013304 aconitate hydratase; Validated; Region: PRK07229 391616013305 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 391616013306 substrate binding site [chemical binding]; other site 391616013307 ligand binding site [chemical binding]; other site 391616013308 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 391616013309 substrate binding site [chemical binding]; other site 391616013310 MarR family; Region: MarR_2; pfam12802 391616013311 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 391616013312 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391616013313 Walker A motif; other site 391616013314 Protein of unknown function (DUF971); Region: DUF971; pfam06155 391616013315 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 391616013316 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391616013317 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 391616013318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391616013319 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391616013320 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391616013321 DNA binding residues [nucleotide binding] 391616013322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013323 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013324 Integrase core domain; Region: rve; pfam00665 391616013325 HipA N-terminal domain; Region: Couple_hipA; cl11853 391616013326 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391616013327 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391616013328 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616013329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616013330 non-specific DNA binding site [nucleotide binding]; other site 391616013331 salt bridge; other site 391616013332 sequence-specific DNA binding site [nucleotide binding]; other site 391616013333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391616013334 Integrase core domain; Region: rve; pfam00665 391616013335 Integrase core domain; Region: rve_3; pfam13683 391616013336 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013337 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013338 Winged helix-turn helix; Region: HTH_29; pfam13551 391616013339 Integrase core domain; Region: rve; pfam00665 391616013340 Integrase core domain; Region: rve_3; pfam13683 391616013341 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 391616013342 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 391616013343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013344 Walker A motif; other site 391616013345 ATP binding site [chemical binding]; other site 391616013346 Walker B motif; other site 391616013347 arginine finger; other site 391616013348 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391616013349 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 391616013350 putative dimer interface [polypeptide binding]; other site 391616013351 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391616013352 Gas vesicle protein G; Region: GvpG; pfam05120 391616013353 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 391616013354 Gas vesicle protein; Region: Gas_vesicle; pfam00741 391616013355 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391616013356 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391616013357 HSP70 interaction site [polypeptide binding]; other site 391616013358 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391616013359 Gas vesicle protein; Region: Gas_vesicle; cl02954 391616013360 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 391616013361 Gas vesicle protein K; Region: GvpK; pfam05121 391616013362 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013363 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013364 Integrase core domain; Region: rve; pfam00665 391616013365 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391616013366 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391616013367 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391616013368 Winged helix-turn helix; Region: HTH_29; pfam13551 391616013369 Winged helix-turn helix; Region: HTH_33; pfam13592 391616013370 DDE superfamily endonuclease; Region: DDE_3; pfam13358 391616013371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 391616013372 transposase; Validated; Region: PRK08181 391616013373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391616013374 Walker A motif; other site 391616013375 ATP binding site [chemical binding]; other site 391616013376 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391616013377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391616013378 DNA-binding site [nucleotide binding]; DNA binding site 391616013379 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391616013380 DDE domain; Region: DDE_Tnp_IS240; pfam13610 391616013381 Integrase core domain; Region: rve; pfam00665 391616013382 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391616013383 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 391616013384 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 391616013385 Transposase, Mutator family; Region: Transposase_mut; pfam00872 391616013386 MULE transposase domain; Region: MULE; pfam10551 391616013387 HTH-like domain; Region: HTH_21; pfam13276 391616013388 Integrase core domain; Region: rve; pfam00665 391616013389 Integrase core domain; Region: rve_3; pfam13683 391616013390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391616013391 Transposase; Region: HTH_Tnp_1; pfam01527 391616013392 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616013393 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391616013394 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391616013395 DctM-like transporters; Region: DctM; pfam06808 391616013396 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391616013397 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_1; cd03326 391616013398 putative active site pocket [active] 391616013399 metal binding site [ion binding]; metal-binding site 391616013400 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391616013401 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391616013402 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013403 Integrase core domain; Region: rve; pfam00665 391616013404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013405 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013406 Integrase core domain; Region: rve; pfam00665 391616013407 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391616013408 IHF dimer interface [polypeptide binding]; other site 391616013409 IHF - DNA interface [nucleotide binding]; other site 391616013410 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 391616013411 Protein of unknown function (DUF993); Region: DUF993; pfam06187 391616013412 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 391616013413 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 391616013414 MOFRL family; Region: MOFRL; pfam05161 391616013415 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 391616013416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391616013417 NAD(P) binding site [chemical binding]; other site 391616013418 active site 391616013419 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391616013420 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391616013421 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391616013422 active site 391616013423 catalytic tetrad [active] 391616013424 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 391616013425 Coenzyme A transferase; Region: CoA_trans; smart00882 391616013426 Coenzyme A transferase; Region: CoA_trans; cl17247 391616013427 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391616013428 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 391616013429 NAD(P) binding site [chemical binding]; other site 391616013430 catalytic residues [active] 391616013431 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391616013432 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391616013433 Walker A/P-loop; other site 391616013434 ATP binding site [chemical binding]; other site 391616013435 Q-loop/lid; other site 391616013436 ABC transporter signature motif; other site 391616013437 Walker B; other site 391616013438 D-loop; other site 391616013439 H-loop/switch region; other site 391616013440 TOBE domain; Region: TOBE; pfam03459 391616013441 TOBE domain; Region: TOBE_2; pfam08402 391616013442 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391616013443 active site 2 [active] 391616013444 active site 1 [active] 391616013445 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391616013446 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391616013447 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391616013448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616013449 dimer interface [polypeptide binding]; other site 391616013450 conserved gate region; other site 391616013451 putative PBP binding loops; other site 391616013452 ABC-ATPase subunit interface; other site 391616013453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391616013454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391616013455 dimer interface [polypeptide binding]; other site 391616013456 conserved gate region; other site 391616013457 putative PBP binding loops; other site 391616013458 ABC-ATPase subunit interface; other site 391616013459 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391616013460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391616013461 choline dehydrogenase; Validated; Region: PRK02106 391616013462 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391616013463 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 391616013464 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 391616013465 ligand binding site [chemical binding]; other site 391616013466 homodimer interface [polypeptide binding]; other site 391616013467 NAD(P) binding site [chemical binding]; other site 391616013468 trimer interface B [polypeptide binding]; other site 391616013469 trimer interface A [polypeptide binding]; other site 391616013470 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391616013471 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 391616013472 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 391616013473 Y-family of DNA polymerases; Region: PolY; cd00424 391616013474 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 391616013475 DNA binding site [nucleotide binding] 391616013476 Transposase IS200 like; Region: Y1_Tnp; pfam01797 391616013477 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 391616013478 Helix-turn-helix domain; Region: HTH_38; pfam13936 391616013479 Integrase core domain; Region: rve; pfam00665 391616013480 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391616013481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616013482 non-specific DNA binding site [nucleotide binding]; other site 391616013483 salt bridge; other site 391616013484 sequence-specific DNA binding site [nucleotide binding]; other site 391616013485 Cupin domain; Region: Cupin_2; pfam07883 391616013486 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391616013487 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391616013488 DctM-like transporters; Region: DctM; pfam06808 391616013489 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616013490 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616013491 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391616013492 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616013493 Uncharacterized conserved protein [Function unknown]; Region: COG5476 391616013494 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 391616013495 MlrC C-terminus; Region: MlrC_C; pfam07171 391616013496 D-glutamate deacylase; Validated; Region: PRK09061 391616013497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616013498 active site 391616013499 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391616013500 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391616013501 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391616013502 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391616013503 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013504 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391616013506 Integrase core domain; Region: rve; pfam00665 391616013507 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391616013508 TPP-binding site [chemical binding]; other site 391616013509 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 391616013510 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 391616013511 PYR/PP interface [polypeptide binding]; other site 391616013512 dimer interface [polypeptide binding]; other site 391616013513 TPP binding site [chemical binding]; other site 391616013514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 391616013515 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 391616013516 Integrase core domain; Region: rve; pfam00665 391616013517 HipA N-terminal domain; Region: Couple_hipA; pfam13657 391616013518 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391616013519 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 391616013520 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391616013521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391616013522 non-specific DNA binding site [nucleotide binding]; other site 391616013523 salt bridge; other site 391616013524 sequence-specific DNA binding site [nucleotide binding]; other site 391616013525 acyl-CoA synthetase; Validated; Region: PRK07470 391616013526 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391616013527 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 391616013528 acyl-activating enzyme (AAE) consensus motif; other site 391616013529 putative AMP binding site [chemical binding]; other site 391616013530 putative active site [active] 391616013531 putative CoA binding site [chemical binding]; other site 391616013532 acetyl-CoA acetyltransferase; Provisional; Region: PRK07516 391616013533 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 391616013534 active site 391616013535 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391616013536 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391616013537 Bacterial transcriptional regulator; Region: IclR; pfam01614 391616013538 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391616013539 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391616013540 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391616013541 DctM-like transporters; Region: DctM; pfam06808 391616013542 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391616013543 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391616013544 classical (c) SDRs; Region: SDR_c; cd05233 391616013545 NAD(P) binding site [chemical binding]; other site 391616013546 active site 391616013547 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616013548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013549 Transposase [DNA replication, recombination, and repair]; Region: COG5433 391616013550 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 391616013551 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391616013552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013553 PIN domain of the VapC-like UPF0110 protein Mb0640 and homologs; Region: PIN_UPF0110; cd09871 391616013554 putative active site [active] 391616013555 Protein of unknown function (DUF3625); Region: DUF3625; pfam12293 391616013556 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 391616013557 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 391616013558 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880