-- dump date 20140619_223957 -- class Genbank::misc_feature -- table misc_feature_note -- id note 203123000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 203123000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 203123000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123000004 Walker A motif; other site 203123000005 ATP binding site [chemical binding]; other site 203123000006 Walker B motif; other site 203123000007 arginine finger; other site 203123000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 203123000009 DnaA box-binding interface [nucleotide binding]; other site 203123000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 203123000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 203123000012 putative DNA binding surface [nucleotide binding]; other site 203123000013 dimer interface [polypeptide binding]; other site 203123000014 beta-clamp/clamp loader binding surface; other site 203123000015 beta-clamp/translesion DNA polymerase binding surface; other site 203123000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 203123000017 recombination protein F; Reviewed; Region: recF; PRK00064 203123000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 203123000019 Walker A/P-loop; other site 203123000020 ATP binding site [chemical binding]; other site 203123000021 Q-loop/lid; other site 203123000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123000023 ABC transporter signature motif; other site 203123000024 Walker B; other site 203123000025 D-loop; other site 203123000026 H-loop/switch region; other site 203123000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 203123000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123000029 ATP binding site [chemical binding]; other site 203123000030 Mg2+ binding site [ion binding]; other site 203123000031 G-X-G motif; other site 203123000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 203123000033 anchoring element; other site 203123000034 dimer interface [polypeptide binding]; other site 203123000035 ATP binding site [chemical binding]; other site 203123000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 203123000037 active site 203123000038 putative metal-binding site [ion binding]; other site 203123000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 203123000040 DNA gyrase subunit A; Validated; Region: PRK05560 203123000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 203123000042 CAP-like domain; other site 203123000043 active site 203123000044 primary dimer interface [polypeptide binding]; other site 203123000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123000051 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 203123000052 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 203123000053 homodimer interface [polypeptide binding]; other site 203123000054 NAD binding pocket [chemical binding]; other site 203123000055 ATP binding pocket [chemical binding]; other site 203123000056 Mg binding site [ion binding]; other site 203123000057 active-site loop [active] 203123000058 multicopper oxidase; Provisional; Region: PRK10965 203123000059 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 203123000060 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 203123000061 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 203123000062 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 203123000063 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 203123000064 dimer interface [polypeptide binding]; other site 203123000065 ssDNA binding site [nucleotide binding]; other site 203123000066 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123000067 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 203123000068 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 203123000069 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 203123000070 DHH family; Region: DHH; pfam01368 203123000071 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 203123000072 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 203123000073 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 203123000074 replicative DNA helicase; Region: DnaB; TIGR00665 203123000075 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 203123000076 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 203123000077 Walker A motif; other site 203123000078 ATP binding site [chemical binding]; other site 203123000079 Walker B motif; other site 203123000080 DNA binding loops [nucleotide binding] 203123000081 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 203123000082 active site 203123000083 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 203123000084 putative active site [active] 203123000085 dimerization interface [polypeptide binding]; other site 203123000086 putative tRNAtyr binding site [nucleotide binding]; other site 203123000087 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 203123000088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123000089 Walker A/P-loop; other site 203123000090 ATP binding site [chemical binding]; other site 203123000091 Q-loop/lid; other site 203123000092 ABC transporter signature motif; other site 203123000093 Walker B; other site 203123000094 D-loop; other site 203123000095 H-loop/switch region; other site 203123000096 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 203123000097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 203123000098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123000099 dimer interface [polypeptide binding]; other site 203123000100 conserved gate region; other site 203123000101 putative PBP binding loops; other site 203123000102 ABC-ATPase subunit interface; other site 203123000103 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 203123000104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123000105 dimer interface [polypeptide binding]; other site 203123000106 conserved gate region; other site 203123000107 putative PBP binding loops; other site 203123000108 ABC-ATPase subunit interface; other site 203123000109 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 203123000110 trimer interface [polypeptide binding]; other site 203123000111 active site 203123000112 G bulge; other site 203123000113 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 203123000114 glyoxylate reductase; Reviewed; Region: PRK13243 203123000115 NAD binding site [chemical binding]; other site 203123000116 Cupin domain; Region: Cupin_2; cl17218 203123000117 Cupin domain; Region: Cupin_2; pfam07883 203123000118 fumarate hydratase; Reviewed; Region: fumC; PRK00485 203123000119 Class II fumarases; Region: Fumarase_classII; cd01362 203123000120 active site 203123000121 tetramer interface [polypeptide binding]; other site 203123000122 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 203123000123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123000124 Walker A/P-loop; other site 203123000125 ATP binding site [chemical binding]; other site 203123000126 Q-loop/lid; other site 203123000127 ABC transporter signature motif; other site 203123000128 Walker B; other site 203123000129 D-loop; other site 203123000130 H-loop/switch region; other site 203123000131 Integral membrane protein DUF95; Region: DUF95; pfam01944 203123000132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123000133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123000134 active site 203123000135 catalytic tetrad [active] 203123000136 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 203123000137 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 203123000138 putative active site [active] 203123000139 hypothetical protein; Provisional; Region: PRK10621 203123000140 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 203123000141 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 203123000142 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 203123000143 Ca binding site [ion binding]; other site 203123000144 active site 203123000145 catalytic site [active] 203123000146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000148 putative substrate translocation pore; other site 203123000149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000150 Transcriptional regulators [Transcription]; Region: PurR; COG1609 203123000151 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123000152 DNA binding site [nucleotide binding] 203123000153 domain linker motif; other site 203123000154 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 203123000155 dimerization interface [polypeptide binding]; other site 203123000156 ligand binding site [chemical binding]; other site 203123000157 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 203123000158 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 203123000159 putative NAD(P) binding site [chemical binding]; other site 203123000160 active site 203123000161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123000162 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 203123000163 DNA-binding interface [nucleotide binding]; DNA binding site 203123000164 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 203123000165 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203123000166 non-specific DNA binding site [nucleotide binding]; other site 203123000167 salt bridge; other site 203123000168 sequence-specific DNA binding site [nucleotide binding]; other site 203123000169 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 203123000170 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203123000171 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 203123000172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000173 putative substrate translocation pore; other site 203123000174 putative oxidoreductase; Provisional; Region: PRK10206 203123000175 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 203123000176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 203123000177 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 203123000178 homodimer interface [polypeptide binding]; other site 203123000179 homotetramer interface [polypeptide binding]; other site 203123000180 active site pocket [active] 203123000181 cleavage site 203123000182 Predicted membrane protein [Function unknown]; Region: COG2261 203123000183 Predicted membrane protein [Function unknown]; Region: COG2261 203123000184 Asp23 family; Region: Asp23; pfam03780 203123000185 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 203123000186 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203123000187 Serine hydrolase; Region: Ser_hydrolase; cl17834 203123000188 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 203123000189 Divergent AAA domain; Region: AAA_4; pfam04326 203123000190 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 203123000191 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 203123000192 substrate binding pocket [chemical binding]; other site 203123000193 aspartate-rich region 2; other site 203123000194 substrate-Mg2+ binding site; other site 203123000195 oxidoreductase; Provisional; Region: PRK07985 203123000196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123000197 NAD(P) binding site [chemical binding]; other site 203123000198 active site 203123000199 CsbD-like; Region: CsbD; pfam05532 203123000200 Predicted membrane protein [Function unknown]; Region: COG2261 203123000201 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123000202 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123000203 active site 203123000204 catalytic tetrad [active] 203123000205 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 203123000206 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203123000207 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 203123000208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000209 putative substrate translocation pore; other site 203123000210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000211 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 203123000212 putative substrate translocation pore; other site 203123000213 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 203123000214 acetoin reductases; Region: 23BDH; TIGR02415 203123000215 NAD binding site [chemical binding]; other site 203123000216 homotetramer interface [polypeptide binding]; other site 203123000217 homodimer interface [polypeptide binding]; other site 203123000218 active site 203123000219 substrate binding site [chemical binding]; other site 203123000220 short chain dehydrogenase; Provisional; Region: PRK12744 203123000221 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 203123000222 NADP binding site [chemical binding]; other site 203123000223 homodimer interface [polypeptide binding]; other site 203123000224 active site 203123000225 substrate binding site [chemical binding]; other site 203123000226 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 203123000227 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 203123000228 DNA binding residues [nucleotide binding] 203123000229 putative dimer interface [polypeptide binding]; other site 203123000230 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 203123000231 trimer interface [polypeptide binding]; other site 203123000232 active site 203123000233 substrate binding site [chemical binding]; other site 203123000234 CoA binding site [chemical binding]; other site 203123000235 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 203123000236 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203123000237 NAD(P) binding site [chemical binding]; other site 203123000238 MarR family; Region: MarR; pfam01047 203123000239 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123000240 catalytic core [active] 203123000241 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 203123000242 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 203123000243 Beta-lactamase; Region: Beta-lactamase; pfam00144 203123000244 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 203123000245 DNA topoisomerase III; Provisional; Region: PRK07726 203123000246 active site 203123000247 putative interdomain interaction site [polypeptide binding]; other site 203123000248 putative metal-binding site [ion binding]; other site 203123000249 putative nucleotide binding site [chemical binding]; other site 203123000250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 203123000251 domain I; other site 203123000252 DNA binding groove [nucleotide binding] 203123000253 phosphate binding site [ion binding]; other site 203123000254 domain II; other site 203123000255 domain III; other site 203123000256 nucleotide binding site [chemical binding]; other site 203123000257 catalytic site [active] 203123000258 domain IV; other site 203123000259 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 203123000260 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 203123000261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123000262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123000263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000264 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000265 putative substrate translocation pore; other site 203123000266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000267 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 203123000268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203123000269 non-specific DNA binding site [nucleotide binding]; other site 203123000270 salt bridge; other site 203123000271 sequence-specific DNA binding site [nucleotide binding]; other site 203123000272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123000273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123000274 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 203123000275 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203123000276 active site 203123000277 metal binding site [ion binding]; metal-binding site 203123000278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203123000279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123000280 active site 203123000281 phosphorylation site [posttranslational modification] 203123000282 intermolecular recognition site; other site 203123000283 dimerization interface [polypeptide binding]; other site 203123000284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 203123000285 DNA binding site [nucleotide binding] 203123000286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 203123000287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 203123000288 dimerization interface [polypeptide binding]; other site 203123000289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 203123000290 putative active site [active] 203123000291 heme pocket [chemical binding]; other site 203123000292 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 203123000293 dimer interface [polypeptide binding]; other site 203123000294 phosphorylation site [posttranslational modification] 203123000295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123000296 ATP binding site [chemical binding]; other site 203123000297 Mg2+ binding site [ion binding]; other site 203123000298 G-X-G motif; other site 203123000299 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 203123000300 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 203123000301 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 203123000302 Predicted membrane protein [Function unknown]; Region: COG3462 203123000303 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203123000304 Domain of unknown function DUF20; Region: UPF0118; pfam01594 203123000305 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 203123000306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123000307 S-adenosylmethionine binding site [chemical binding]; other site 203123000308 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 203123000309 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 203123000310 P-loop; other site 203123000311 Magnesium ion binding site [ion binding]; other site 203123000312 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 203123000313 Magnesium ion binding site [ion binding]; other site 203123000314 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 203123000315 ParB-like nuclease domain; Region: ParB; smart00470 203123000316 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 203123000317 GTP-binding protein YchF; Reviewed; Region: PRK09601 203123000318 YchF GTPase; Region: YchF; cd01900 203123000319 G1 box; other site 203123000320 GTP/Mg2+ binding site [chemical binding]; other site 203123000321 Switch I region; other site 203123000322 G2 box; other site 203123000323 Switch II region; other site 203123000324 G3 box; other site 203123000325 G4 box; other site 203123000326 G5 box; other site 203123000327 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 203123000328 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 203123000329 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203123000330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123000331 active site 203123000332 phosphorylation site [posttranslational modification] 203123000333 intermolecular recognition site; other site 203123000334 dimerization interface [polypeptide binding]; other site 203123000335 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 203123000336 DNA binding site [nucleotide binding] 203123000337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203123000338 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 203123000339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 203123000340 dimer interface [polypeptide binding]; other site 203123000341 phosphorylation site [posttranslational modification] 203123000342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123000343 ATP binding site [chemical binding]; other site 203123000344 Mg2+ binding site [ion binding]; other site 203123000345 G-X-G motif; other site 203123000346 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 203123000347 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123000348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123000349 catalytic core [active] 203123000350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123000351 QueT transporter; Region: QueT; pfam06177 203123000352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 203123000353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123000354 DNA binding site [nucleotide binding] 203123000355 domain linker motif; other site 203123000356 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 203123000357 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 203123000358 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 203123000359 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 203123000360 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 203123000361 substrate binding site [chemical binding]; other site 203123000362 ATP binding site [chemical binding]; other site 203123000363 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 203123000364 active site 203123000365 dimer interface [polypeptide binding]; other site 203123000366 magnesium binding site [ion binding]; other site 203123000367 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 203123000368 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 203123000369 tetramer interface [polypeptide binding]; other site 203123000370 active site 203123000371 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000373 putative substrate translocation pore; other site 203123000374 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 203123000375 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 203123000376 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 203123000377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000379 putative substrate translocation pore; other site 203123000380 Domain of unknown function DUF21; Region: DUF21; pfam01595 203123000381 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 203123000382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 203123000383 Transporter associated domain; Region: CorC_HlyC; pfam03471 203123000384 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293 203123000385 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 203123000386 catalytic residues [active] 203123000387 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 203123000388 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 203123000389 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 203123000390 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 203123000391 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 203123000392 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 203123000393 dimer interface [polypeptide binding]; other site 203123000394 putative radical transfer pathway; other site 203123000395 diiron center [ion binding]; other site 203123000396 tyrosyl radical; other site 203123000397 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203123000398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123000399 active site 203123000400 phosphorylation site [posttranslational modification] 203123000401 intermolecular recognition site; other site 203123000402 dimerization interface [polypeptide binding]; other site 203123000403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 203123000404 DNA binding site [nucleotide binding] 203123000405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203123000406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 203123000407 dimer interface [polypeptide binding]; other site 203123000408 phosphorylation site [posttranslational modification] 203123000409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123000410 ATP binding site [chemical binding]; other site 203123000411 Mg2+ binding site [ion binding]; other site 203123000412 G-X-G motif; other site 203123000413 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 203123000414 amidase catalytic site [active] 203123000415 Zn binding residues [ion binding]; other site 203123000416 substrate binding site [chemical binding]; other site 203123000417 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 203123000418 active site 203123000419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 203123000420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123000421 DNA binding site [nucleotide binding] 203123000422 domain linker motif; other site 203123000423 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 203123000424 dimerization interface [polypeptide binding]; other site 203123000425 ligand binding site [chemical binding]; other site 203123000426 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 203123000427 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 203123000428 ATP binding site [chemical binding]; other site 203123000429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000430 putative substrate translocation pore; other site 203123000431 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000432 Chorismate mutase type II; Region: CM_2; pfam01817 203123000433 Prephenate dehydratase; Region: PDT; pfam00800 203123000434 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 203123000435 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 203123000436 hinge; other site 203123000437 active site 203123000438 shikimate kinase; Reviewed; Region: aroK; PRK00131 203123000439 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 203123000440 ADP binding site [chemical binding]; other site 203123000441 magnesium binding site [ion binding]; other site 203123000442 putative shikimate binding site; other site 203123000443 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 203123000444 active site 203123000445 tetramer interface [polypeptide binding]; other site 203123000446 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 203123000447 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 203123000448 HflX GTPase family; Region: HflX; cd01878 203123000449 G1 box; other site 203123000450 GTP/Mg2+ binding site [chemical binding]; other site 203123000451 Switch I region; other site 203123000452 G2 box; other site 203123000453 G3 box; other site 203123000454 Switch II region; other site 203123000455 G4 box; other site 203123000456 G5 box; other site 203123000457 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 203123000458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123000459 active site 203123000460 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123000461 catalytic tetrad [active] 203123000462 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 203123000463 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 203123000464 active site 203123000465 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 203123000466 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 203123000467 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123000468 active site 203123000469 dimer interface [polypeptide binding]; other site 203123000470 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 203123000471 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 203123000472 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123000473 active site 203123000474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123000475 Coenzyme A binding pocket [chemical binding]; other site 203123000476 alanine racemase; Reviewed; Region: alr; PRK00053 203123000477 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 203123000478 active site 203123000479 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203123000480 dimer interface [polypeptide binding]; other site 203123000481 substrate binding site [chemical binding]; other site 203123000482 catalytic residues [active] 203123000483 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 203123000484 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 203123000485 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 203123000486 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 203123000487 Sulfatase; Region: Sulfatase; pfam00884 203123000488 SURF4 family; Region: SURF4; pfam02077 203123000489 Acylphosphatase; Region: Acylphosphatase; pfam00708 203123000490 drug efflux system protein MdtG; Provisional; Region: PRK09874 203123000491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000492 putative substrate translocation pore; other site 203123000493 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 203123000494 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 203123000495 Cl binding site [ion binding]; other site 203123000496 oligomer interface [polypeptide binding]; other site 203123000497 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 203123000498 putative active site [active] 203123000499 Cobalt transport protein; Region: CbiQ; cl00463 203123000500 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123000501 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123000502 Walker A/P-loop; other site 203123000503 ATP binding site [chemical binding]; other site 203123000504 Q-loop/lid; other site 203123000505 ABC transporter signature motif; other site 203123000506 Walker B; other site 203123000507 D-loop; other site 203123000508 H-loop/switch region; other site 203123000509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203123000510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123000511 Walker A/P-loop; other site 203123000512 ATP binding site [chemical binding]; other site 203123000513 Q-loop/lid; other site 203123000514 ABC transporter signature motif; other site 203123000515 Walker B; other site 203123000516 D-loop; other site 203123000517 H-loop/switch region; other site 203123000518 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 203123000519 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 203123000520 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 203123000521 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 203123000522 active site 203123000523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123000524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123000525 Predicted membrane protein [Function unknown]; Region: COG1511 203123000526 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 203123000527 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 203123000528 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 203123000529 putative active site [active] 203123000530 catalytic residue [active] 203123000531 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 203123000532 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 203123000533 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203123000534 ATP binding site [chemical binding]; other site 203123000535 putative Mg++ binding site [ion binding]; other site 203123000536 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123000537 nucleotide binding region [chemical binding]; other site 203123000538 ATP-binding site [chemical binding]; other site 203123000539 TRCF domain; Region: TRCF; pfam03461 203123000540 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203123000541 RNA binding surface [nucleotide binding]; other site 203123000542 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 203123000543 Septum formation initiator; Region: DivIC; cl17659 203123000544 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123000545 active site 203123000546 FtsH Extracellular; Region: FtsH_ext; pfam06480 203123000547 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 203123000548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123000549 Walker A motif; other site 203123000550 ATP binding site [chemical binding]; other site 203123000551 Walker B motif; other site 203123000552 arginine finger; other site 203123000553 Peptidase family M41; Region: Peptidase_M41; pfam01434 203123000554 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 203123000555 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 203123000556 dimerization interface [polypeptide binding]; other site 203123000557 domain crossover interface; other site 203123000558 redox-dependent activation switch; other site 203123000559 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 203123000560 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 203123000561 dimer interface [polypeptide binding]; other site 203123000562 putative anticodon binding site; other site 203123000563 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 203123000564 motif 1; other site 203123000565 active site 203123000566 motif 2; other site 203123000567 motif 3; other site 203123000568 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000570 putative substrate translocation pore; other site 203123000571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000572 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 203123000573 Protein of unknown function (DUF805); Region: DUF805; pfam05656 203123000574 HlyD family secretion protein; Region: HlyD_3; pfam13437 203123000575 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123000576 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123000577 Walker A/P-loop; other site 203123000578 ATP binding site [chemical binding]; other site 203123000579 Q-loop/lid; other site 203123000580 ABC transporter signature motif; other site 203123000581 Walker B; other site 203123000582 D-loop; other site 203123000583 H-loop/switch region; other site 203123000584 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 203123000585 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 203123000586 FtsX-like permease family; Region: FtsX; pfam02687 203123000587 Integral membrane protein DUF95; Region: DUF95; pfam01944 203123000588 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 203123000589 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 203123000590 Walker A/P-loop; other site 203123000591 ATP binding site [chemical binding]; other site 203123000592 Q-loop/lid; other site 203123000593 ABC transporter signature motif; other site 203123000594 Walker B; other site 203123000595 D-loop; other site 203123000596 H-loop/switch region; other site 203123000597 SH3-like domain; Region: SH3_8; pfam13457 203123000598 SH3-like domain; Region: SH3_8; pfam13457 203123000599 SH3-like domain; Region: SH3_8; pfam13457 203123000600 SH3-like domain; Region: SH3_8; pfam13457 203123000601 SH3-like domain; Region: SH3_8; pfam13457 203123000602 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 203123000603 active site 203123000604 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 203123000605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123000606 Coenzyme A binding pocket [chemical binding]; other site 203123000607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 203123000608 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203123000609 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 203123000610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123000612 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 203123000613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 203123000614 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 203123000615 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123000616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123000617 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123000618 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 203123000619 NAD(P) binding site [chemical binding]; other site 203123000620 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203123000621 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203123000622 Ligand binding site; other site 203123000623 Putative Catalytic site; other site 203123000624 DXD motif; other site 203123000625 conserved hypothetical integral membrane protein; Region: TIGR03766 203123000626 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 203123000627 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 203123000628 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 203123000629 active site 203123000630 methionine cluster; other site 203123000631 phosphorylation site [posttranslational modification] 203123000632 metal binding site [ion binding]; metal-binding site 203123000633 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 203123000634 active site 203123000635 P-loop; other site 203123000636 phosphorylation site [posttranslational modification] 203123000637 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 203123000638 beta-galactosidase; Region: BGL; TIGR03356 203123000639 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 203123000640 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 203123000641 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 203123000642 putative active site [active] 203123000643 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 203123000644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123000645 DNA-binding site [nucleotide binding]; DNA binding site 203123000646 transcriptional repressor RbsR; Provisional; Region: PRK10423 203123000647 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 203123000648 putative dimerization interface [polypeptide binding]; other site 203123000649 putative ligand binding site [chemical binding]; other site 203123000650 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 203123000651 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 203123000652 putative N- and C-terminal domain interface [polypeptide binding]; other site 203123000653 putative active site [active] 203123000654 MgATP binding site [chemical binding]; other site 203123000655 catalytic site [active] 203123000656 metal binding site [ion binding]; metal-binding site 203123000657 putative carbohydrate binding site [chemical binding]; other site 203123000658 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 203123000659 active site 203123000660 catalytic residues [active] 203123000661 HTH domain; Region: HTH_11; pfam08279 203123000662 PRD domain; Region: PRD; pfam00874 203123000663 PRD domain; Region: PRD; pfam00874 203123000664 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 203123000665 active site 203123000666 P-loop; other site 203123000667 phosphorylation site [posttranslational modification] 203123000668 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 203123000669 active site 203123000670 phosphorylation site [posttranslational modification] 203123000671 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 203123000672 active site 203123000673 phosphorylation site [posttranslational modification] 203123000674 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 203123000675 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 203123000676 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 203123000677 active site 203123000678 P-loop; other site 203123000679 phosphorylation site [posttranslational modification] 203123000680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123000681 NADH(P)-binding; Region: NAD_binding_10; pfam13460 203123000682 NAD(P) binding site [chemical binding]; other site 203123000683 active site 203123000684 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 203123000685 active site 203123000686 zinc binding site [ion binding]; other site 203123000687 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 203123000688 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 203123000689 homodimer interface [polypeptide binding]; other site 203123000690 substrate-cofactor binding pocket; other site 203123000691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123000692 catalytic residue [active] 203123000693 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 203123000694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123000695 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 203123000696 NAD(P) binding site [chemical binding]; other site 203123000697 active site 203123000698 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123000699 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123000700 active site 203123000701 catalytic tetrad [active] 203123000702 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 203123000703 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 203123000704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123000705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123000706 manganese transport protein MntH; Reviewed; Region: PRK00701 203123000707 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 203123000708 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 203123000709 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 203123000710 G1 box; other site 203123000711 GTP/Mg2+ binding site [chemical binding]; other site 203123000712 Switch I region; other site 203123000713 G2 box; other site 203123000714 G3 box; other site 203123000715 Switch II region; other site 203123000716 G4 box; other site 203123000717 G5 box; other site 203123000718 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 203123000719 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 203123000720 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 203123000721 RDD family; Region: RDD; pfam06271 203123000722 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 203123000723 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 203123000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123000725 dimer interface [polypeptide binding]; other site 203123000726 conserved gate region; other site 203123000727 putative PBP binding loops; other site 203123000728 ABC-ATPase subunit interface; other site 203123000729 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 203123000730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123000731 dimer interface [polypeptide binding]; other site 203123000732 conserved gate region; other site 203123000733 putative PBP binding loops; other site 203123000734 ABC-ATPase subunit interface; other site 203123000735 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 203123000736 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 203123000737 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 203123000738 dihydroorotase; Validated; Region: pyrC; PRK09357 203123000739 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 203123000740 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 203123000741 active site 203123000742 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 203123000743 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 203123000744 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 203123000745 catalytic site [active] 203123000746 subunit interface [polypeptide binding]; other site 203123000747 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 203123000748 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203123000749 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 203123000750 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 203123000751 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203123000752 ATP-grasp domain; Region: ATP-grasp_4; cl17255 203123000753 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 203123000754 IMP binding site; other site 203123000755 dimer interface [polypeptide binding]; other site 203123000756 interdomain contacts; other site 203123000757 partial ornithine binding site; other site 203123000758 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 203123000759 active site 203123000760 dimer interface [polypeptide binding]; other site 203123000761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123000762 active site 203123000763 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 203123000764 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 203123000765 active site 203123000766 FMN binding site [chemical binding]; other site 203123000767 substrate binding site [chemical binding]; other site 203123000768 catalytic residues [active] 203123000769 homodimer interface [polypeptide binding]; other site 203123000770 benzoate transport; Region: 2A0115; TIGR00895 203123000771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000772 putative substrate translocation pore; other site 203123000773 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 203123000774 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 203123000775 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 203123000776 zinc binding site [ion binding]; other site 203123000777 putative ligand binding site [chemical binding]; other site 203123000778 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 203123000779 TM-ABC transporter signature motif; other site 203123000780 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 203123000781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123000782 Walker A/P-loop; other site 203123000783 ATP binding site [chemical binding]; other site 203123000784 Q-loop/lid; other site 203123000785 ABC transporter signature motif; other site 203123000786 Walker B; other site 203123000787 D-loop; other site 203123000788 H-loop/switch region; other site 203123000789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123000790 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 203123000791 Walker A/P-loop; other site 203123000792 ATP binding site [chemical binding]; other site 203123000793 Q-loop/lid; other site 203123000794 ABC transporter signature motif; other site 203123000795 Walker B; other site 203123000796 D-loop; other site 203123000797 H-loop/switch region; other site 203123000798 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 203123000799 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 203123000800 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 203123000801 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123000802 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 203123000803 Walker A/P-loop; other site 203123000804 ATP binding site [chemical binding]; other site 203123000805 Q-loop/lid; other site 203123000806 ABC transporter signature motif; other site 203123000807 Walker B; other site 203123000808 D-loop; other site 203123000809 H-loop/switch region; other site 203123000810 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 203123000811 CoenzymeA binding site [chemical binding]; other site 203123000812 subunit interaction site [polypeptide binding]; other site 203123000813 PHB binding site; other site 203123000814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 203123000815 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 203123000816 substrate binding site [chemical binding]; other site 203123000817 oxyanion hole (OAH) forming residues; other site 203123000818 trimer interface [polypeptide binding]; other site 203123000819 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 203123000820 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 203123000821 acyl-activating enzyme (AAE) consensus motif; other site 203123000822 putative AMP binding site [chemical binding]; other site 203123000823 putative active site [active] 203123000824 putative CoA binding site [chemical binding]; other site 203123000825 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 203123000826 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 203123000827 active site 203123000828 Zn binding site [ion binding]; other site 203123000829 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 203123000830 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 203123000831 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 203123000832 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 203123000833 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 203123000834 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 203123000835 DltD N-terminal region; Region: DltD_N; pfam04915 203123000836 DltD central region; Region: DltD_M; pfam04918 203123000837 DltD C-terminal region; Region: DltD_C; pfam04914 203123000838 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 203123000839 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 203123000840 putative dimer interface [polypeptide binding]; other site 203123000841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000843 Amidohydrolase; Region: Amidohydro_2; pfam04909 203123000844 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 203123000845 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 203123000846 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 203123000847 HPr interaction site; other site 203123000848 glycerol kinase (GK) interaction site [polypeptide binding]; other site 203123000849 active site 203123000850 phosphorylation site [posttranslational modification] 203123000851 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 203123000852 active site turn [active] 203123000853 phosphorylation site [posttranslational modification] 203123000854 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 203123000855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123000856 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123000857 putative substrate translocation pore; other site 203123000858 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 203123000859 active site 203123000860 catalytic residues [active] 203123000861 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 203123000862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123000863 DNA binding site [nucleotide binding] 203123000864 domain linker motif; other site 203123000865 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 203123000866 putative dimerization interface [polypeptide binding]; other site 203123000867 putative ligand binding site [chemical binding]; other site 203123000868 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 203123000869 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 203123000870 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 203123000871 galactokinase; Provisional; Region: PRK05322 203123000872 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 203123000873 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 203123000874 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 203123000875 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 203123000876 seadornavirus VP4 protein; Region: seadorna_VP4; TIGR04235 203123000877 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 203123000878 Helix-turn-helix domain; Region: HTH_38; pfam13936 203123000879 Integrase core domain; Region: rve; pfam00665 203123000880 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 203123000881 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 203123000882 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 203123000883 Part of AAA domain; Region: AAA_19; pfam13245 203123000884 Family description; Region: UvrD_C_2; pfam13538 203123000885 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123000886 catalytic core [active] 203123000887 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123000888 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 203123000889 Domain of unknown function DUF20; Region: UPF0118; pfam01594 203123000890 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203123000891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123000892 Coenzyme A binding pocket [chemical binding]; other site 203123000893 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 203123000894 trimer interface [polypeptide binding]; other site 203123000895 active site 203123000896 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 203123000897 nudix motif; other site 203123000898 DNA repair protein RadA; Provisional; Region: PRK11823 203123000899 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 203123000900 Walker A motif/ATP binding site; other site 203123000901 ATP binding site [chemical binding]; other site 203123000902 Walker B motif; other site 203123000903 beta-phosphoglucomutase; Region: bPGM; TIGR01990 203123000904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123000905 motif II; other site 203123000906 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 203123000907 active site 203123000908 dimerization interface [polypeptide binding]; other site 203123000909 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 203123000910 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 203123000911 active site 203123000912 HIGH motif; other site 203123000913 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 203123000914 active site 203123000915 KMSKS motif; other site 203123000916 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123000917 active site 203123000918 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 203123000919 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 203123000920 NAD binding site [chemical binding]; other site 203123000921 catalytic residues [active] 203123000922 substrate binding site [chemical binding]; other site 203123000923 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 203123000924 Lipase (class 2); Region: Lipase_2; pfam01674 203123000925 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 203123000926 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 203123000927 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 203123000928 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 203123000929 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 203123000930 tetramer interface [polypeptide binding]; other site 203123000931 TPP-binding site [chemical binding]; other site 203123000932 heterodimer interface [polypeptide binding]; other site 203123000933 phosphorylation loop region [posttranslational modification] 203123000934 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 203123000935 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 203123000936 alpha subunit interface [polypeptide binding]; other site 203123000937 TPP binding site [chemical binding]; other site 203123000938 heterodimer interface [polypeptide binding]; other site 203123000939 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 203123000940 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 203123000941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 203123000942 E3 interaction surface; other site 203123000943 lipoyl attachment site [posttranslational modification]; other site 203123000944 e3 binding domain; Region: E3_binding; pfam02817 203123000945 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 203123000946 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 203123000947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 203123000948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 203123000949 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203123000950 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 203123000951 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 203123000952 aromatic amino acid aminotransferase; Validated; Region: PRK07309 203123000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203123000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123000955 homodimer interface [polypeptide binding]; other site 203123000956 catalytic residue [active] 203123000957 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 203123000958 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203123000959 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 203123000960 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 203123000961 active site 203123000962 metal binding site [ion binding]; metal-binding site 203123000963 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 203123000964 active site 203123000965 P-loop; other site 203123000966 phosphorylation site [posttranslational modification] 203123000967 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 203123000968 active site 203123000969 methionine cluster; other site 203123000970 phosphorylation site [posttranslational modification] 203123000971 metal binding site [ion binding]; metal-binding site 203123000972 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 203123000973 beta-galactosidase; Region: BGL; TIGR03356 203123000974 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 203123000975 beta-galactosidase; Region: BGL; TIGR03356 203123000976 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 203123000977 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 203123000978 Uncharacterized conserved protein [Function unknown]; Region: COG3589 203123000979 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 203123000980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 203123000981 Sterol carrier protein domain; Region: SCP2_2; pfam13530 203123000982 Integrase core domain; Region: rve; pfam00665 203123000983 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 203123000984 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203123000985 Soluble P-type ATPase [General function prediction only]; Region: COG4087 203123000986 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 203123000987 amphipathic channel; other site 203123000988 Asn-Pro-Ala signature motifs; other site 203123000989 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203123000990 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 203123000991 catalytic residues [active] 203123000992 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 203123000993 putative homodimer interface [polypeptide binding]; other site 203123000994 putative homotetramer interface [polypeptide binding]; other site 203123000995 putative metal binding site [ion binding]; other site 203123000996 putative homodimer-homodimer interface [polypeptide binding]; other site 203123000997 putative allosteric switch controlling residues; other site 203123000998 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 203123000999 Ferritin-like domain; Region: Ferritin; pfam00210 203123001000 dimerization interface [polypeptide binding]; other site 203123001001 DPS ferroxidase diiron center [ion binding]; other site 203123001002 ion pore; other site 203123001003 Heavy-metal-associated domain; Region: HMA; pfam00403 203123001004 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 203123001005 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 203123001006 ligand binding site [chemical binding]; other site 203123001007 flexible hinge region; other site 203123001008 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 203123001009 non-specific DNA interactions [nucleotide binding]; other site 203123001010 DNA binding site [nucleotide binding] 203123001011 sequence specific DNA binding site [nucleotide binding]; other site 203123001012 putative cAMP binding site [chemical binding]; other site 203123001013 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 203123001014 Helix-turn-helix domain; Region: HTH_38; pfam13936 203123001015 Integrase core domain; Region: rve; pfam00665 203123001016 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 203123001017 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 203123001018 Cl binding site [ion binding]; other site 203123001019 oligomer interface [polypeptide binding]; other site 203123001020 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 203123001021 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 203123001022 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 203123001023 YibE/F-like protein; Region: YibE_F; pfam07907 203123001024 YibE/F-like protein; Region: YibE_F; pfam07907 203123001025 sugar phosphate phosphatase; Provisional; Region: PRK10513 203123001026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123001027 active site 203123001028 motif I; other site 203123001029 motif II; other site 203123001030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123001031 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 203123001032 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 203123001033 active site 203123001034 substrate binding site [chemical binding]; other site 203123001035 metal binding site [ion binding]; metal-binding site 203123001036 Isochorismatase family; Region: Isochorismatase; pfam00857 203123001037 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 203123001038 catalytic triad [active] 203123001039 conserved cis-peptide bond; other site 203123001040 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 203123001041 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 203123001042 ligand binding site [chemical binding]; other site 203123001043 homodimer interface [polypeptide binding]; other site 203123001044 NAD(P) binding site [chemical binding]; other site 203123001045 trimer interface B [polypeptide binding]; other site 203123001046 trimer interface A [polypeptide binding]; other site 203123001047 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 203123001048 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 203123001049 excinuclease ABC subunit B; Provisional; Region: PRK05298 203123001050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203123001051 ATP binding site [chemical binding]; other site 203123001052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123001053 nucleotide binding region [chemical binding]; other site 203123001054 ATP-binding site [chemical binding]; other site 203123001055 Ultra-violet resistance protein B; Region: UvrB; pfam12344 203123001056 UvrB/uvrC motif; Region: UVR; pfam02151 203123001057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123001058 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 203123001059 NAD(P) binding site [chemical binding]; other site 203123001060 active site 203123001061 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 203123001062 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 203123001063 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 203123001064 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 203123001065 uracil transporter; Provisional; Region: PRK10720 203123001066 Protein of unknown function (DUF419); Region: DUF419; cl15265 203123001067 Bacterial SH3 domain; Region: SH3_4; pfam06347 203123001068 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 203123001069 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 203123001070 active site 203123001071 metal binding site [ion binding]; metal-binding site 203123001072 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 203123001073 active site 203123001074 phosphorylation site [posttranslational modification] 203123001075 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 203123001076 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 203123001077 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 203123001078 active pocket/dimerization site; other site 203123001079 active site 203123001080 phosphorylation site [posttranslational modification] 203123001081 Beta-lactamase; Region: Beta-lactamase; pfam00144 203123001082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 203123001083 H+ Antiporter protein; Region: 2A0121; TIGR00900 203123001084 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 203123001085 4-aminobutyrate aminotransferase; Provisional; Region: PRK08593 203123001086 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 203123001087 inhibitor-cofactor binding pocket; inhibition site 203123001088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123001089 catalytic residue [active] 203123001090 amino acid transporter; Region: 2A0306; TIGR00909 203123001091 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 203123001092 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 203123001093 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123001094 catalytic Zn binding site [ion binding]; other site 203123001095 structural Zn binding site [ion binding]; other site 203123001096 tetramer interface [polypeptide binding]; other site 203123001097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123001098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123001099 WHG domain; Region: WHG; pfam13305 203123001100 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 203123001101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123001102 NAD(P) binding site [chemical binding]; other site 203123001103 active site 203123001104 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 203123001105 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 203123001106 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 203123001107 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 203123001108 Predicted membrane protein [Function unknown]; Region: COG2246 203123001109 GtrA-like protein; Region: GtrA; pfam04138 203123001110 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 203123001111 active site 203123001112 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 203123001113 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 203123001114 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 203123001115 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 203123001116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203123001117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123001118 homodimer interface [polypeptide binding]; other site 203123001119 catalytic residue [active] 203123001120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123001121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123001122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203123001123 dimerization interface [polypeptide binding]; other site 203123001124 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 203123001125 D-lactate dehydrogenase; Validated; Region: PRK08605 203123001126 homodimer interface [polypeptide binding]; other site 203123001127 ligand binding site [chemical binding]; other site 203123001128 NAD binding site [chemical binding]; other site 203123001129 catalytic site [active] 203123001130 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 203123001131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123001132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123001133 Walker A/P-loop; other site 203123001134 ATP binding site [chemical binding]; other site 203123001135 Q-loop/lid; other site 203123001136 ABC transporter signature motif; other site 203123001137 Walker B; other site 203123001138 D-loop; other site 203123001139 H-loop/switch region; other site 203123001140 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 203123001141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123001142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123001143 Walker A/P-loop; other site 203123001144 ATP binding site [chemical binding]; other site 203123001145 Q-loop/lid; other site 203123001146 ABC transporter signature motif; other site 203123001147 Walker B; other site 203123001148 D-loop; other site 203123001149 H-loop/switch region; other site 203123001150 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 203123001151 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 203123001152 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 203123001153 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 203123001154 Malic enzyme, N-terminal domain; Region: malic; pfam00390 203123001155 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 203123001156 NAD(P) binding pocket [chemical binding]; other site 203123001157 Membrane transport protein; Region: Mem_trans; pfam03547 203123001158 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 203123001159 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203123001160 active site 203123001161 nucleotide binding site [chemical binding]; other site 203123001162 HIGH motif; other site 203123001163 KMSKS motif; other site 203123001164 citrate lyase subunit gamma; Provisional; Region: PRK13253 203123001165 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 203123001166 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 203123001167 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 203123001168 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 203123001169 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 203123001170 Part of AAA domain; Region: AAA_19; pfam13245 203123001171 Family description; Region: UvrD_C_2; pfam13538 203123001172 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 203123001173 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 203123001174 nucleotide binding pocket [chemical binding]; other site 203123001175 K-X-D-G motif; other site 203123001176 catalytic site [active] 203123001177 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 203123001178 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 203123001179 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 203123001180 Dimer interface [polypeptide binding]; other site 203123001181 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 203123001182 putative dimer interface [polypeptide binding]; other site 203123001183 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 203123001184 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 203123001185 putative dimer interface [polypeptide binding]; other site 203123001186 ribosome maturation protein RimP; Reviewed; Region: PRK00092 203123001187 Sm and related proteins; Region: Sm_like; cl00259 203123001188 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 203123001189 putative oligomer interface [polypeptide binding]; other site 203123001190 putative RNA binding site [nucleotide binding]; other site 203123001191 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 203123001192 NusA N-terminal domain; Region: NusA_N; pfam08529 203123001193 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 203123001194 RNA binding site [nucleotide binding]; other site 203123001195 homodimer interface [polypeptide binding]; other site 203123001196 NusA-like KH domain; Region: KH_5; pfam13184 203123001197 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 203123001198 G-X-X-G motif; other site 203123001199 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 203123001200 putative RNA binding cleft [nucleotide binding]; other site 203123001201 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 203123001202 translation initiation factor IF-2; Region: IF-2; TIGR00487 203123001203 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 203123001204 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 203123001205 G1 box; other site 203123001206 putative GEF interaction site [polypeptide binding]; other site 203123001207 GTP/Mg2+ binding site [chemical binding]; other site 203123001208 Switch I region; other site 203123001209 G2 box; other site 203123001210 G3 box; other site 203123001211 Switch II region; other site 203123001212 G4 box; other site 203123001213 G5 box; other site 203123001214 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 203123001215 Translation-initiation factor 2; Region: IF-2; pfam11987 203123001216 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 203123001217 Ribosome-binding factor A; Region: RBFA; pfam02033 203123001218 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 203123001219 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 203123001220 active site 203123001221 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 203123001222 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 203123001223 Substrate-binding site [chemical binding]; other site 203123001224 Substrate specificity [chemical binding]; other site 203123001225 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 203123001226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123001227 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123001228 Walker A/P-loop; other site 203123001229 ATP binding site [chemical binding]; other site 203123001230 Q-loop/lid; other site 203123001231 ABC transporter signature motif; other site 203123001232 Walker B; other site 203123001233 D-loop; other site 203123001234 H-loop/switch region; other site 203123001235 seryl-tRNA synthetase; Provisional; Region: PRK05431 203123001236 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 203123001237 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 203123001238 dimer interface [polypeptide binding]; other site 203123001239 active site 203123001240 motif 1; other site 203123001241 motif 2; other site 203123001242 motif 3; other site 203123001243 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 203123001244 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 203123001245 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 203123001246 Asp23 family; Region: Asp23; pfam03780 203123001247 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 203123001248 DAK2 domain; Region: Dak2; pfam02734 203123001249 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 203123001250 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 203123001251 generic binding surface II; other site 203123001252 ssDNA binding site; other site 203123001253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203123001254 ATP binding site [chemical binding]; other site 203123001255 putative Mg++ binding site [ion binding]; other site 203123001256 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123001257 nucleotide binding region [chemical binding]; other site 203123001258 ATP-binding site [chemical binding]; other site 203123001259 putative phosphate acyltransferase; Provisional; Region: PRK05331 203123001260 acyl carrier protein; Provisional; Region: acpP; PRK00982 203123001261 ribonuclease III; Reviewed; Region: rnc; PRK00102 203123001262 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 203123001263 dimerization interface [polypeptide binding]; other site 203123001264 active site 203123001265 metal binding site [ion binding]; metal-binding site 203123001266 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 203123001267 dsRNA binding site [nucleotide binding]; other site 203123001268 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 203123001269 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 203123001270 Walker A/P-loop; other site 203123001271 ATP binding site [chemical binding]; other site 203123001272 Q-loop/lid; other site 203123001273 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 203123001274 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 203123001275 ABC transporter signature motif; other site 203123001276 Walker B; other site 203123001277 D-loop; other site 203123001278 H-loop/switch region; other site 203123001279 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 203123001280 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 203123001281 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 203123001282 P loop; other site 203123001283 GTP binding site [chemical binding]; other site 203123001284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 203123001285 signal recognition particle protein; Provisional; Region: PRK10867 203123001286 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 203123001287 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 203123001288 P loop; other site 203123001289 GTP binding site [chemical binding]; other site 203123001290 Signal peptide binding domain; Region: SRP_SPB; pfam02978 203123001291 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 203123001292 MutS domain III; Region: MutS_III; pfam05192 203123001293 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 203123001294 Walker A/P-loop; other site 203123001295 ATP binding site [chemical binding]; other site 203123001296 Q-loop/lid; other site 203123001297 ABC transporter signature motif; other site 203123001298 Walker B; other site 203123001299 D-loop; other site 203123001300 H-loop/switch region; other site 203123001301 Smr domain; Region: Smr; pfam01713 203123001302 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 203123001303 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 203123001304 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 203123001305 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 203123001306 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 203123001307 active site 203123001308 dimer interface [polypeptide binding]; other site 203123001309 motif 1; other site 203123001310 motif 2; other site 203123001311 motif 3; other site 203123001312 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 203123001313 anticodon binding site; other site 203123001314 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 203123001315 trimer interface [polypeptide binding]; other site 203123001316 active site 203123001317 G bulge; other site 203123001318 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 203123001319 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 203123001320 active pocket/dimerization site; other site 203123001321 active site 203123001322 phosphorylation site [posttranslational modification] 203123001323 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 203123001324 active site 203123001325 phosphorylation site [posttranslational modification] 203123001326 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 203123001327 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 203123001328 Domain of unknown function (DUF956); Region: DUF956; pfam06115 203123001329 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 203123001330 putative dimer interface [polypeptide binding]; other site 203123001331 catalytic triad [active] 203123001332 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123001333 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123001334 Walker A/P-loop; other site 203123001335 ATP binding site [chemical binding]; other site 203123001336 Q-loop/lid; other site 203123001337 ABC transporter signature motif; other site 203123001338 Walker B; other site 203123001339 D-loop; other site 203123001340 H-loop/switch region; other site 203123001341 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 203123001342 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 203123001343 FtsX-like permease family; Region: FtsX; pfam02687 203123001344 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 203123001345 Sel1-like repeats; Region: SEL1; smart00671 203123001346 Sel1-like repeats; Region: SEL1; smart00671 203123001347 Sel1-like repeats; Region: SEL1; smart00671 203123001348 Sel1-like repeats; Region: SEL1; smart00671 203123001349 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 203123001350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123001351 putative substrate translocation pore; other site 203123001352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123001353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123001354 dimerization interface [polypeptide binding]; other site 203123001355 putative DNA binding site [nucleotide binding]; other site 203123001356 putative Zn2+ binding site [ion binding]; other site 203123001357 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 203123001358 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 203123001359 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 203123001360 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 203123001361 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 203123001362 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 203123001363 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 203123001364 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 203123001365 active site 203123001366 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203123001367 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203123001368 Ligand binding site; other site 203123001369 Putative Catalytic site; other site 203123001370 DXD motif; other site 203123001371 conserved hypothetical integral membrane protein; Region: TIGR03766 203123001372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203123001373 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123001374 active site 203123001375 phosphorylation site [posttranslational modification] 203123001376 intermolecular recognition site; other site 203123001377 dimerization interface [polypeptide binding]; other site 203123001378 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 203123001379 DNA binding site [nucleotide binding] 203123001380 HAMP domain; Region: HAMP; pfam00672 203123001381 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203123001382 dimerization interface [polypeptide binding]; other site 203123001383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 203123001384 dimer interface [polypeptide binding]; other site 203123001385 phosphorylation site [posttranslational modification] 203123001386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123001387 ATP binding site [chemical binding]; other site 203123001388 Mg2+ binding site [ion binding]; other site 203123001389 G-X-G motif; other site 203123001390 FMN-binding domain; Region: FMN_bind; cl01081 203123001391 ApbE family; Region: ApbE; pfam02424 203123001392 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 203123001393 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 203123001394 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 203123001395 FAD binding pocket [chemical binding]; other site 203123001396 conserved FAD binding motif [chemical binding]; other site 203123001397 phosphate binding motif [ion binding]; other site 203123001398 beta-alpha-beta structure motif; other site 203123001399 NAD binding pocket [chemical binding]; other site 203123001400 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 203123001401 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 203123001402 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203123001403 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123001404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123001405 dimerization interface [polypeptide binding]; other site 203123001406 putative DNA binding site [nucleotide binding]; other site 203123001407 putative Zn2+ binding site [ion binding]; other site 203123001408 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123001409 MarR family; Region: MarR; pfam01047 203123001410 MarR family; Region: MarR_2; cl17246 203123001411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123001412 putative substrate translocation pore; other site 203123001413 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 203123001414 Enterocin A Immunity; Region: EntA_Immun; pfam08951 203123001415 methionine sulfoxide reductase A; Provisional; Region: PRK14054 203123001416 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123001417 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123001418 active site 203123001419 catalytic tetrad [active] 203123001420 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 203123001421 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 203123001422 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 203123001423 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 203123001424 Clp amino terminal domain; Region: Clp_N; pfam02861 203123001425 Clp amino terminal domain; Region: Clp_N; pfam02861 203123001426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001427 Walker A motif; other site 203123001428 ATP binding site [chemical binding]; other site 203123001429 Walker B motif; other site 203123001430 arginine finger; other site 203123001431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001432 Walker A motif; other site 203123001433 ATP binding site [chemical binding]; other site 203123001434 Walker B motif; other site 203123001435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203123001436 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 203123001437 nudix motif; other site 203123001438 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 203123001439 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 203123001440 putative active site [active] 203123001441 putative FMN binding site [chemical binding]; other site 203123001442 putative substrate binding site [chemical binding]; other site 203123001443 putative catalytic residue [active] 203123001444 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 203123001445 ABC transporter; Region: ABC_tran_2; pfam12848 203123001446 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 203123001447 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 203123001448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123001449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123001450 active site 203123001451 catalytic tetrad [active] 203123001452 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 203123001453 nudix motif; other site 203123001454 Predicted transcriptional regulators [Transcription]; Region: COG1695 203123001455 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 203123001456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 203123001457 Transposase; Region: DDE_Tnp_ISL3; pfam01610 203123001458 Protein of unknown function, DUF488; Region: DUF488; cl01246 203123001459 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 203123001460 putative active site [active] 203123001461 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 203123001462 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 203123001463 NAD binding site [chemical binding]; other site 203123001464 substrate binding site [chemical binding]; other site 203123001465 catalytic Zn binding site [ion binding]; other site 203123001466 tetramer interface [polypeptide binding]; other site 203123001467 structural Zn binding site [ion binding]; other site 203123001468 putative acyltransferase; Provisional; Region: PRK05790 203123001469 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 203123001470 dimer interface [polypeptide binding]; other site 203123001471 active site 203123001472 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 203123001473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 203123001474 active site 203123001475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123001476 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 203123001477 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 203123001478 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 203123001479 active site 203123001480 xanthine permease; Region: pbuX; TIGR03173 203123001481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123001482 active site 203123001483 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 203123001484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123001485 Coenzyme A binding pocket [chemical binding]; other site 203123001486 Transcriptional regulators [Transcription]; Region: MarR; COG1846 203123001487 MarR family; Region: MarR_2; pfam12802 203123001488 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 203123001489 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001490 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 203123001491 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 203123001492 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001493 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001494 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001495 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001496 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 203123001497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203123001498 sequence-specific DNA binding site [nucleotide binding]; other site 203123001499 salt bridge; other site 203123001500 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 203123001501 hypothetical protein; Provisional; Region: PRK06762 203123001502 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 203123001503 Isochorismatase family; Region: Isochorismatase; pfam00857 203123001504 catalytic triad [active] 203123001505 conserved cis-peptide bond; other site 203123001506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123001507 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203123001508 dimerization interface [polypeptide binding]; other site 203123001509 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 203123001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123001511 putative PBP binding loops; other site 203123001512 dimer interface [polypeptide binding]; other site 203123001513 ABC-ATPase subunit interface; other site 203123001514 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 203123001515 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 203123001516 Walker A/P-loop; other site 203123001517 ATP binding site [chemical binding]; other site 203123001518 Q-loop/lid; other site 203123001519 ABC transporter signature motif; other site 203123001520 Walker B; other site 203123001521 D-loop; other site 203123001522 H-loop/switch region; other site 203123001523 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 203123001524 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123001525 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 203123001526 NAD binding site [chemical binding]; other site 203123001527 dimer interface [polypeptide binding]; other site 203123001528 substrate binding site [chemical binding]; other site 203123001529 peptide chain release factor 2; Validated; Region: prfB; PRK00578 203123001530 PCRF domain; Region: PCRF; pfam03462 203123001531 RF-1 domain; Region: RF-1; pfam00472 203123001532 PBP superfamily domain; Region: PBP_like_2; cl17296 203123001533 PBP superfamily domain; Region: PBP_like_2; cl17296 203123001534 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 203123001535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123001536 dimer interface [polypeptide binding]; other site 203123001537 conserved gate region; other site 203123001538 putative PBP binding loops; other site 203123001539 ABC-ATPase subunit interface; other site 203123001540 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 203123001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123001542 dimer interface [polypeptide binding]; other site 203123001543 conserved gate region; other site 203123001544 putative PBP binding loops; other site 203123001545 ABC-ATPase subunit interface; other site 203123001546 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 203123001547 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 203123001548 Walker A/P-loop; other site 203123001549 ATP binding site [chemical binding]; other site 203123001550 Q-loop/lid; other site 203123001551 ABC transporter signature motif; other site 203123001552 Walker B; other site 203123001553 D-loop; other site 203123001554 H-loop/switch region; other site 203123001555 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 203123001556 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 203123001557 Walker A/P-loop; other site 203123001558 ATP binding site [chemical binding]; other site 203123001559 Q-loop/lid; other site 203123001560 ABC transporter signature motif; other site 203123001561 Walker B; other site 203123001562 D-loop; other site 203123001563 H-loop/switch region; other site 203123001564 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 203123001565 PhoU domain; Region: PhoU; pfam01895 203123001566 PhoU domain; Region: PhoU; pfam01895 203123001567 Membrane protein of unknown function; Region: DUF360; pfam04020 203123001568 HPr kinase/phosphorylase; Provisional; Region: PRK05428 203123001569 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 203123001570 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 203123001571 Hpr binding site; other site 203123001572 active site 203123001573 homohexamer subunit interaction site [polypeptide binding]; other site 203123001574 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 203123001575 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 203123001576 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 203123001577 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 203123001578 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 203123001579 active site 203123001580 tetramer interface; other site 203123001581 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 203123001582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 203123001583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 203123001584 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 203123001585 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 203123001586 phosphate binding site [ion binding]; other site 203123001587 putative substrate binding pocket [chemical binding]; other site 203123001588 dimer interface [polypeptide binding]; other site 203123001589 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 203123001590 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 203123001591 Clp protease; Region: CLP_protease; pfam00574 203123001592 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 203123001593 oligomer interface [polypeptide binding]; other site 203123001594 active site residues [active] 203123001595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 203123001596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001597 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203123001598 Walker A motif; other site 203123001599 ATP binding site [chemical binding]; other site 203123001600 Walker B motif; other site 203123001601 arginine finger; other site 203123001602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001603 Walker A motif; other site 203123001604 ATP binding site [chemical binding]; other site 203123001605 Walker B motif; other site 203123001606 arginine finger; other site 203123001607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203123001608 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 203123001609 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 203123001610 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 203123001611 active site 203123001612 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 203123001613 putative ligand binding site [chemical binding]; other site 203123001614 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 203123001615 NAD binding site [chemical binding]; other site 203123001616 catalytic site [active] 203123001617 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 203123001618 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 203123001619 RuvA N terminal domain; Region: RuvA_N; pfam01330 203123001620 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 203123001621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001622 Walker A motif; other site 203123001623 ATP binding site [chemical binding]; other site 203123001624 Walker B motif; other site 203123001625 arginine finger; other site 203123001626 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 203123001627 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 203123001628 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 203123001629 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 203123001630 active site 203123001631 GTP-binding protein LepA; Provisional; Region: PRK05433 203123001632 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 203123001633 G1 box; other site 203123001634 putative GEF interaction site [polypeptide binding]; other site 203123001635 GTP/Mg2+ binding site [chemical binding]; other site 203123001636 Switch I region; other site 203123001637 G2 box; other site 203123001638 G3 box; other site 203123001639 Switch II region; other site 203123001640 G4 box; other site 203123001641 G5 box; other site 203123001642 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 203123001643 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 203123001644 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 203123001645 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 203123001646 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 203123001647 putative NAD(P) binding site [chemical binding]; other site 203123001648 dimer interface [polypeptide binding]; other site 203123001649 RNA methyltransferase, RsmE family; Region: TIGR00046 203123001650 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 203123001651 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 203123001652 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203123001653 Zn2+ binding site [ion binding]; other site 203123001654 Mg2+ binding site [ion binding]; other site 203123001655 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 203123001656 synthetase active site [active] 203123001657 NTP binding site [chemical binding]; other site 203123001658 metal binding site [ion binding]; metal-binding site 203123001659 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 203123001660 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 203123001661 Bacterial SH3 domain; Region: SH3_3; pfam08239 203123001662 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 203123001663 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 203123001664 active site 203123001665 metal binding site [ion binding]; metal-binding site 203123001666 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 203123001667 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 203123001668 dimer interface [polypeptide binding]; other site 203123001669 motif 1; other site 203123001670 active site 203123001671 motif 2; other site 203123001672 motif 3; other site 203123001673 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 203123001674 anticodon binding site; other site 203123001675 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 203123001676 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 203123001677 dimer interface [polypeptide binding]; other site 203123001678 anticodon binding site; other site 203123001679 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 203123001680 homodimer interface [polypeptide binding]; other site 203123001681 motif 1; other site 203123001682 active site 203123001683 motif 2; other site 203123001684 GAD domain; Region: GAD; pfam02938 203123001685 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 203123001686 active site 203123001687 motif 3; other site 203123001688 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 203123001689 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 203123001690 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 203123001691 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 203123001692 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 203123001693 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 203123001694 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 203123001695 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 203123001696 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 203123001697 putative translocon binding site; other site 203123001698 protein-rRNA interface [nucleotide binding]; other site 203123001699 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 203123001700 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 203123001701 G-X-X-G motif; other site 203123001702 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 203123001703 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 203123001704 23S rRNA interface [nucleotide binding]; other site 203123001705 5S rRNA interface [nucleotide binding]; other site 203123001706 putative antibiotic binding site [chemical binding]; other site 203123001707 L25 interface [polypeptide binding]; other site 203123001708 L27 interface [polypeptide binding]; other site 203123001709 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 203123001710 putative translocon interaction site; other site 203123001711 23S rRNA interface [nucleotide binding]; other site 203123001712 signal recognition particle (SRP54) interaction site; other site 203123001713 L23 interface [polypeptide binding]; other site 203123001714 trigger factor interaction site; other site 203123001715 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 203123001716 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 203123001717 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 203123001718 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 203123001719 RNA binding site [nucleotide binding]; other site 203123001720 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 203123001721 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 203123001722 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 203123001723 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 203123001724 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 203123001725 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 203123001726 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 203123001727 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 203123001728 5S rRNA interface [nucleotide binding]; other site 203123001729 L27 interface [polypeptide binding]; other site 203123001730 23S rRNA interface [nucleotide binding]; other site 203123001731 L5 interface [polypeptide binding]; other site 203123001732 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 203123001733 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 203123001734 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 203123001735 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 203123001736 23S rRNA binding site [nucleotide binding]; other site 203123001737 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 203123001738 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 203123001739 SecY translocase; Region: SecY; pfam00344 203123001740 adenylate kinase; Reviewed; Region: adk; PRK00279 203123001741 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 203123001742 AMP-binding site [chemical binding]; other site 203123001743 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 203123001744 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 203123001745 rRNA binding site [nucleotide binding]; other site 203123001746 predicted 30S ribosome binding site; other site 203123001747 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 203123001748 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 203123001749 30S ribosomal protein S13; Region: bact_S13; TIGR03631 203123001750 30S ribosomal protein S11; Validated; Region: PRK05309 203123001751 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 203123001752 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 203123001753 alphaNTD - beta interaction site [polypeptide binding]; other site 203123001754 alphaNTD homodimer interface [polypeptide binding]; other site 203123001755 alphaNTD - beta' interaction site [polypeptide binding]; other site 203123001756 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 203123001757 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 203123001758 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203123001759 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123001760 Walker A/P-loop; other site 203123001761 ATP binding site [chemical binding]; other site 203123001762 Q-loop/lid; other site 203123001763 ABC transporter signature motif; other site 203123001764 Walker B; other site 203123001765 D-loop; other site 203123001766 H-loop/switch region; other site 203123001767 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13641 203123001768 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123001769 Walker A/P-loop; other site 203123001770 ATP binding site [chemical binding]; other site 203123001771 Q-loop/lid; other site 203123001772 ABC transporter signature motif; other site 203123001773 Walker B; other site 203123001774 D-loop; other site 203123001775 H-loop/switch region; other site 203123001776 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 203123001777 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 203123001778 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 203123001779 dimerization interface 3.5A [polypeptide binding]; other site 203123001780 active site 203123001781 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 203123001782 23S rRNA interface [nucleotide binding]; other site 203123001783 L3 interface [polypeptide binding]; other site 203123001784 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 203123001785 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 203123001786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123001787 Walker A/P-loop; other site 203123001788 ATP binding site [chemical binding]; other site 203123001789 Q-loop/lid; other site 203123001790 ABC transporter signature motif; other site 203123001791 Walker B; other site 203123001792 D-loop; other site 203123001793 H-loop/switch region; other site 203123001794 TOBE domain; Region: TOBE_2; pfam08402 203123001795 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 203123001796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123001797 dimer interface [polypeptide binding]; other site 203123001798 conserved gate region; other site 203123001799 putative PBP binding loops; other site 203123001800 ABC-ATPase subunit interface; other site 203123001801 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 203123001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123001803 dimer interface [polypeptide binding]; other site 203123001804 conserved gate region; other site 203123001805 putative PBP binding loops; other site 203123001806 ABC-ATPase subunit interface; other site 203123001807 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 203123001808 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 203123001809 EamA-like transporter family; Region: EamA; pfam00892 203123001810 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 203123001811 EamA-like transporter family; Region: EamA; pfam00892 203123001812 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 203123001813 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 203123001814 glutaminase active site [active] 203123001815 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 203123001816 dimer interface [polypeptide binding]; other site 203123001817 active site 203123001818 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 203123001819 dimer interface [polypeptide binding]; other site 203123001820 active site 203123001821 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 203123001822 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 203123001823 active site 203123001824 dimer interface [polypeptide binding]; other site 203123001825 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 203123001826 dimer interface [polypeptide binding]; other site 203123001827 active site 203123001828 hypothetical protein; Provisional; Region: PRK00967 203123001829 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 203123001830 Phosphoglycerate kinase; Region: PGK; pfam00162 203123001831 substrate binding site [chemical binding]; other site 203123001832 hinge regions; other site 203123001833 ADP binding site [chemical binding]; other site 203123001834 catalytic site [active] 203123001835 Protein of unknown function (DUF1516); Region: DUF1516; pfam07457 203123001836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001837 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203123001838 Walker A motif; other site 203123001839 ATP binding site [chemical binding]; other site 203123001840 Walker B motif; other site 203123001841 arginine finger; other site 203123001842 UvrB/uvrC motif; Region: UVR; pfam02151 203123001843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001844 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 203123001845 Walker A motif; other site 203123001846 ATP binding site [chemical binding]; other site 203123001847 Walker B motif; other site 203123001848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 203123001849 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 203123001850 dimerization domain swap beta strand [polypeptide binding]; other site 203123001851 regulatory protein interface [polypeptide binding]; other site 203123001852 active site 203123001853 regulatory phosphorylation site [posttranslational modification]; other site 203123001854 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 203123001855 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 203123001856 active site 203123001857 trimer interface [polypeptide binding]; other site 203123001858 allosteric site; other site 203123001859 active site lid [active] 203123001860 hexamer (dimer of trimers) interface [polypeptide binding]; other site 203123001861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123001862 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 203123001863 motif II; other site 203123001864 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 203123001865 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 203123001866 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 203123001867 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 203123001868 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 203123001869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123001870 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 203123001871 putative ADP-binding pocket [chemical binding]; other site 203123001872 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123001873 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203123001874 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 203123001875 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 203123001876 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 203123001877 Sulfatase; Region: Sulfatase; pfam00884 203123001878 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 203123001879 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 203123001880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203123001881 catalytic residue [active] 203123001882 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 203123001883 putative substrate binding site [chemical binding]; other site 203123001884 putative ATP binding site [chemical binding]; other site 203123001885 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 203123001886 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 203123001887 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 203123001888 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 203123001889 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 203123001890 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 203123001891 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 203123001892 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 203123001893 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 203123001894 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 203123001895 beta subunit interaction interface [polypeptide binding]; other site 203123001896 Walker A motif; other site 203123001897 ATP binding site [chemical binding]; other site 203123001898 Walker B motif; other site 203123001899 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 203123001900 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 203123001901 core domain interface [polypeptide binding]; other site 203123001902 delta subunit interface [polypeptide binding]; other site 203123001903 epsilon subunit interface [polypeptide binding]; other site 203123001904 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 203123001905 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 203123001906 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 203123001907 alpha subunit interaction interface [polypeptide binding]; other site 203123001908 Walker A motif; other site 203123001909 ATP binding site [chemical binding]; other site 203123001910 Walker B motif; other site 203123001911 inhibitor binding site; inhibition site 203123001912 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 203123001913 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 203123001914 gamma subunit interface [polypeptide binding]; other site 203123001915 epsilon subunit interface [polypeptide binding]; other site 203123001916 LBP interface [polypeptide binding]; other site 203123001917 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 203123001918 rod shape-determining protein MreB; Provisional; Region: PRK13930 203123001919 MreB and similar proteins; Region: MreB_like; cd10225 203123001920 nucleotide binding site [chemical binding]; other site 203123001921 Mg binding site [ion binding]; other site 203123001922 putative protofilament interaction site [polypeptide binding]; other site 203123001923 RodZ interaction site [polypeptide binding]; other site 203123001924 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 203123001925 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 203123001926 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 203123001927 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 203123001928 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 203123001929 ATP-grasp domain; Region: ATP-grasp_4; cl17255 203123001930 DNA polymerase I; Provisional; Region: PRK05755 203123001931 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 203123001932 active site 203123001933 metal binding site 1 [ion binding]; metal-binding site 203123001934 putative 5' ssDNA interaction site; other site 203123001935 metal binding site 3; metal-binding site 203123001936 metal binding site 2 [ion binding]; metal-binding site 203123001937 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 203123001938 putative DNA binding site [nucleotide binding]; other site 203123001939 putative metal binding site [ion binding]; other site 203123001940 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 203123001941 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 203123001942 active site 203123001943 DNA binding site [nucleotide binding] 203123001944 catalytic site [active] 203123001945 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 203123001946 nudix motif; other site 203123001947 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 203123001948 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 203123001949 DNA binding site [nucleotide binding] 203123001950 catalytic residue [active] 203123001951 H2TH interface [polypeptide binding]; other site 203123001952 putative catalytic residues [active] 203123001953 turnover-facilitating residue; other site 203123001954 intercalation triad [nucleotide binding]; other site 203123001955 8OG recognition residue [nucleotide binding]; other site 203123001956 putative reading head residues; other site 203123001957 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 203123001958 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 203123001959 dephospho-CoA kinase; Region: TIGR00152 203123001960 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 203123001961 CoA-binding site [chemical binding]; other site 203123001962 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 203123001963 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 203123001964 primosomal protein DnaI; Reviewed; Region: PRK08939 203123001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123001966 Walker A motif; other site 203123001967 ATP binding site [chemical binding]; other site 203123001968 Walker B motif; other site 203123001969 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 203123001970 glutamate racemase; Provisional; Region: PRK00865 203123001971 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 203123001972 active site 203123001973 metal binding site [ion binding]; metal-binding site 203123001974 homotetramer interface [polypeptide binding]; other site 203123001975 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 203123001976 catabolite control protein A; Region: ccpA; TIGR01481 203123001977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123001978 DNA binding site [nucleotide binding] 203123001979 domain linker motif; other site 203123001980 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 203123001981 dimerization interface [polypeptide binding]; other site 203123001982 effector binding site; other site 203123001983 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 203123001984 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 203123001985 catalytic residues [active] 203123001986 catalytic nucleophile [active] 203123001987 Presynaptic Site I dimer interface [polypeptide binding]; other site 203123001988 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 203123001989 Synaptic Flat tetramer interface [polypeptide binding]; other site 203123001990 Synaptic Site I dimer interface [polypeptide binding]; other site 203123001991 DNA binding site [nucleotide binding] 203123001992 WxL domain surface cell wall-binding; Region: WxL; pfam13731 203123001993 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 203123001994 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 203123001995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123001996 acetoin reductase; Validated; Region: PRK08643 203123001997 NAD(P) binding site [chemical binding]; other site 203123001998 active site 203123001999 Predicted transcriptional regulator [Transcription]; Region: COG1959 203123002000 Transcriptional regulator; Region: Rrf2; pfam02082 203123002001 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 203123002002 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 203123002003 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 203123002004 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 203123002005 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 203123002006 putative ligand binding site [chemical binding]; other site 203123002007 putative NAD binding site [chemical binding]; other site 203123002008 catalytic site [active] 203123002009 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 203123002010 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 203123002011 DNA binding residues [nucleotide binding] 203123002012 putative dimer interface [polypeptide binding]; other site 203123002013 short chain dehydrogenase; Provisional; Region: PRK06180 203123002014 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 203123002015 NADP binding site [chemical binding]; other site 203123002016 active site 203123002017 steroid binding site; other site 203123002018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123002019 dimerization interface [polypeptide binding]; other site 203123002020 putative DNA binding site [nucleotide binding]; other site 203123002021 putative Zn2+ binding site [ion binding]; other site 203123002022 H+ Antiporter protein; Region: 2A0121; TIGR00900 203123002023 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 203123002024 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 203123002025 putative ion selectivity filter; other site 203123002026 putative pore gating glutamate residue; other site 203123002027 KTSC domain; Region: KTSC; pfam13619 203123002028 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 203123002029 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 203123002030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123002031 Coenzyme A binding pocket [chemical binding]; other site 203123002032 Homeodomain-like domain; Region: HTH_23; pfam13384 203123002033 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 203123002034 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123002035 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123002036 Predicted esterase [General function prediction only]; Region: COG0627 203123002037 S-formylglutathione hydrolase; Region: PLN02442 203123002038 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 203123002039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123002040 Walker A/P-loop; other site 203123002041 ATP binding site [chemical binding]; other site 203123002042 Q-loop/lid; other site 203123002043 ABC transporter signature motif; other site 203123002044 Walker B; other site 203123002045 D-loop; other site 203123002046 H-loop/switch region; other site 203123002047 LytTr DNA-binding domain; Region: LytTR; smart00850 203123002048 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 203123002049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 203123002050 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 203123002051 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 203123002052 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 203123002053 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123002054 MarR family; Region: MarR_2; pfam12802 203123002055 CrcB-like protein; Region: CRCB; cl09114 203123002056 CrcB-like protein; Region: CRCB; pfam02537 203123002057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123002058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123002059 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 203123002060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123002061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123002062 Walker A/P-loop; other site 203123002063 ATP binding site [chemical binding]; other site 203123002064 Q-loop/lid; other site 203123002065 ABC transporter signature motif; other site 203123002066 Walker B; other site 203123002067 D-loop; other site 203123002068 H-loop/switch region; other site 203123002069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123002070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123002071 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 203123002072 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 203123002073 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 203123002074 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 203123002075 Walker A/P-loop; other site 203123002076 ATP binding site [chemical binding]; other site 203123002077 Q-loop/lid; other site 203123002078 ABC transporter signature motif; other site 203123002079 Walker B; other site 203123002080 D-loop; other site 203123002081 H-loop/switch region; other site 203123002082 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 203123002083 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 203123002084 MgtC family; Region: MgtC; pfam02308 203123002085 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 203123002086 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203123002087 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 203123002088 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 203123002089 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123002090 putative NAD(P) binding site [chemical binding]; other site 203123002091 catalytic Zn binding site [ion binding]; other site 203123002092 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 203123002093 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 203123002094 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 203123002095 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 203123002096 NADH(P)-binding; Region: NAD_binding_10; pfam13460 203123002097 NAD binding site [chemical binding]; other site 203123002098 substrate binding site [chemical binding]; other site 203123002099 putative active site [active] 203123002100 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 203123002101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123002102 Walker A/P-loop; other site 203123002103 ATP binding site [chemical binding]; other site 203123002104 Q-loop/lid; other site 203123002105 ABC transporter signature motif; other site 203123002106 Walker B; other site 203123002107 D-loop; other site 203123002108 H-loop/switch region; other site 203123002109 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 203123002110 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 203123002111 substrate binding pocket [chemical binding]; other site 203123002112 membrane-bound complex binding site; other site 203123002113 hinge residues; other site 203123002114 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203123002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123002116 dimer interface [polypeptide binding]; other site 203123002117 conserved gate region; other site 203123002118 putative PBP binding loops; other site 203123002119 ABC-ATPase subunit interface; other site 203123002120 Predicted membrane protein [Function unknown]; Region: COG2364 203123002121 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 203123002122 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123002123 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 203123002124 dimer interface [polypeptide binding]; other site 203123002125 FMN binding site [chemical binding]; other site 203123002126 NADPH bind site [chemical binding]; other site 203123002127 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 203123002128 short chain dehydrogenase; Provisional; Region: PRK08263 203123002129 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 203123002130 NADP binding site [chemical binding]; other site 203123002131 active site 203123002132 steroid binding site; other site 203123002133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123002134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123002135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123002137 putative substrate translocation pore; other site 203123002138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002139 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 203123002140 ABC-2 type transporter; Region: ABC2_membrane; cl17235 203123002141 cystathionine beta-lyase; Provisional; Region: PRK08064 203123002142 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 203123002143 homodimer interface [polypeptide binding]; other site 203123002144 substrate-cofactor binding pocket; other site 203123002145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123002146 catalytic residue [active] 203123002147 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 203123002148 proposed active site lysine [active] 203123002149 conserved cys residue [active] 203123002150 hypothetical protein; Validated; Region: PRK00110 203123002151 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 203123002152 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 203123002153 Potassium binding sites [ion binding]; other site 203123002154 Cesium cation binding sites [ion binding]; other site 203123002155 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 203123002156 diaminopimelate decarboxylase; Region: lysA; TIGR01048 203123002157 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 203123002158 active site 203123002159 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203123002160 substrate binding site [chemical binding]; other site 203123002161 catalytic residues [active] 203123002162 dimer interface [polypeptide binding]; other site 203123002163 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 203123002164 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 203123002165 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 203123002166 active site 203123002167 trimer interface [polypeptide binding]; other site 203123002168 substrate binding site [chemical binding]; other site 203123002169 CoA binding site [chemical binding]; other site 203123002170 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 203123002171 putative CoA binding site [chemical binding]; other site 203123002172 putative trimer interface [polypeptide binding]; other site 203123002173 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 203123002174 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 203123002175 metal binding site [ion binding]; metal-binding site 203123002176 putative dimer interface [polypeptide binding]; other site 203123002177 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 203123002178 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 203123002179 dimer interface [polypeptide binding]; other site 203123002180 active site 203123002181 catalytic residue [active] 203123002182 dihydrodipicolinate reductase; Provisional; Region: PRK00048 203123002183 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 203123002184 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 203123002185 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 203123002186 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 203123002187 aromatic amino acid aminotransferase; Validated; Region: PRK07309 203123002188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203123002189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123002190 homodimer interface [polypeptide binding]; other site 203123002191 catalytic residue [active] 203123002192 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 203123002193 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 203123002194 dimer interface [polypeptide binding]; other site 203123002195 active site 203123002196 glycine-pyridoxal phosphate binding site [chemical binding]; other site 203123002197 folate binding site [chemical binding]; other site 203123002198 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 203123002199 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 203123002200 Uncharacterized conserved protein [Function unknown]; Region: COG1284 203123002201 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 203123002202 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 203123002203 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 203123002204 thymidylate synthase; Region: thym_sym; TIGR03284 203123002205 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 203123002206 dimerization interface [polypeptide binding]; other site 203123002207 active site 203123002208 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 203123002209 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 203123002210 putative active site [active] 203123002211 putative metal binding site [ion binding]; other site 203123002212 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 203123002213 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203123002214 active site 203123002215 metal binding site [ion binding]; metal-binding site 203123002216 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 203123002217 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 203123002218 primosomal protein N' Region: priA; TIGR00595 203123002219 ATP binding site [chemical binding]; other site 203123002220 putative Mg++ binding site [ion binding]; other site 203123002221 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 203123002222 iron binding site [ion binding]; other site 203123002223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123002224 nucleotide binding region [chemical binding]; other site 203123002225 ATP-binding site [chemical binding]; other site 203123002226 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 203123002227 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 203123002228 putative active site [active] 203123002229 substrate binding site [chemical binding]; other site 203123002230 putative cosubstrate binding site; other site 203123002231 catalytic site [active] 203123002232 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 203123002233 substrate binding site [chemical binding]; other site 203123002234 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 203123002235 active site 203123002236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 203123002237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 203123002238 active site 203123002239 ATP binding site [chemical binding]; other site 203123002240 substrate binding site [chemical binding]; other site 203123002241 activation loop (A-loop); other site 203123002242 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 203123002243 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 203123002244 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 203123002245 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 203123002246 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 203123002247 substrate binding site [chemical binding]; other site 203123002248 hexamer interface [polypeptide binding]; other site 203123002249 metal binding site [ion binding]; metal-binding site 203123002250 Thiamine pyrophosphokinase; Region: TPK; cd07995 203123002251 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 203123002252 active site 203123002253 dimerization interface [polypeptide binding]; other site 203123002254 thiamine binding site [chemical binding]; other site 203123002255 elongation factor Tu; Reviewed; Region: PRK00049 203123002256 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 203123002257 G1 box; other site 203123002258 GEF interaction site [polypeptide binding]; other site 203123002259 GTP/Mg2+ binding site [chemical binding]; other site 203123002260 Switch I region; other site 203123002261 G2 box; other site 203123002262 G3 box; other site 203123002263 Switch II region; other site 203123002264 G4 box; other site 203123002265 G5 box; other site 203123002266 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 203123002267 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 203123002268 Antibiotic Binding Site [chemical binding]; other site 203123002269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203123002270 non-specific DNA binding site [nucleotide binding]; other site 203123002271 salt bridge; other site 203123002272 sequence-specific DNA binding site [nucleotide binding]; other site 203123002273 TPR repeat; Region: TPR_11; pfam13414 203123002274 DNA polymerase IV; Reviewed; Region: PRK03103 203123002275 Y-family of DNA polymerases; Region: PolY; cl12025 203123002276 active site 203123002277 DNA binding site [nucleotide binding] 203123002278 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 203123002279 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 203123002280 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 203123002281 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 203123002282 DNA binding site [nucleotide binding] 203123002283 active site 203123002284 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 203123002285 RimM N-terminal domain; Region: RimM; pfam01782 203123002286 PRC-barrel domain; Region: PRC; pfam05239 203123002287 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 203123002288 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 203123002289 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 203123002290 active site 1 [active] 203123002291 dimer interface [polypeptide binding]; other site 203123002292 hexamer interface [polypeptide binding]; other site 203123002293 active site 2 [active] 203123002294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123002295 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123002296 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 203123002297 NlpC/P60 family; Region: NLPC_P60; pfam00877 203123002298 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 203123002299 active site 203123002300 catalytic residues [active] 203123002301 metal binding site [ion binding]; metal-binding site 203123002302 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 203123002303 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 203123002304 G1 box; other site 203123002305 putative GEF interaction site [polypeptide binding]; other site 203123002306 GTP/Mg2+ binding site [chemical binding]; other site 203123002307 Switch I region; other site 203123002308 G2 box; other site 203123002309 G3 box; other site 203123002310 Switch II region; other site 203123002311 G4 box; other site 203123002312 G5 box; other site 203123002313 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 203123002314 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 203123002315 Transcriptional regulators [Transcription]; Region: PurR; COG1609 203123002316 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123002317 DNA binding site [nucleotide binding] 203123002318 domain linker motif; other site 203123002319 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 203123002320 dimerization interface [polypeptide binding]; other site 203123002321 ligand binding site [chemical binding]; other site 203123002322 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 203123002323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123002324 dimer interface [polypeptide binding]; other site 203123002325 conserved gate region; other site 203123002326 putative PBP binding loops; other site 203123002327 ABC-ATPase subunit interface; other site 203123002328 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 203123002329 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123002330 dimer interface [polypeptide binding]; other site 203123002331 conserved gate region; other site 203123002332 putative PBP binding loops; other site 203123002333 ABC-ATPase subunit interface; other site 203123002334 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 203123002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123002336 active site 203123002337 motif I; other site 203123002338 motif II; other site 203123002339 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 203123002340 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 203123002341 metal binding site [ion binding]; metal-binding site 203123002342 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 203123002343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002344 putative substrate translocation pore; other site 203123002345 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 203123002346 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 203123002347 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 203123002348 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 203123002349 metal binding triad [ion binding]; metal-binding site 203123002350 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 203123002351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123002352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123002353 active site 203123002354 catalytic tetrad [active] 203123002355 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 203123002356 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 203123002357 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 203123002358 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 203123002359 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123002360 Walker A/P-loop; other site 203123002361 ATP binding site [chemical binding]; other site 203123002362 Q-loop/lid; other site 203123002363 ABC transporter signature motif; other site 203123002364 Walker B; other site 203123002365 D-loop; other site 203123002366 H-loop/switch region; other site 203123002367 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 203123002368 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123002369 Walker A/P-loop; other site 203123002370 ATP binding site [chemical binding]; other site 203123002371 Q-loop/lid; other site 203123002372 ABC transporter signature motif; other site 203123002373 Walker B; other site 203123002374 D-loop; other site 203123002375 H-loop/switch region; other site 203123002376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123002377 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 203123002378 Coenzyme A binding pocket [chemical binding]; other site 203123002379 Protein of unknown function, DUF606; Region: DUF606; pfam04657 203123002380 Protein of unknown function, DUF606; Region: DUF606; pfam04657 203123002381 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 203123002382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 203123002383 active site 203123002384 motif I; other site 203123002385 motif II; other site 203123002386 S-adenosylmethionine synthetase; Validated; Region: PRK05250 203123002387 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 203123002388 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 203123002389 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 203123002390 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 203123002391 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 203123002392 HIGH motif; other site 203123002393 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 203123002394 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 203123002395 active site 203123002396 KMSKS motif; other site 203123002397 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 203123002398 tRNA binding surface [nucleotide binding]; other site 203123002399 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 203123002400 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 203123002401 peptide binding site [polypeptide binding]; other site 203123002402 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 203123002403 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 203123002404 peptide binding site [polypeptide binding]; other site 203123002405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 203123002406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123002407 dimer interface [polypeptide binding]; other site 203123002408 conserved gate region; other site 203123002409 putative PBP binding loops; other site 203123002410 ABC-ATPase subunit interface; other site 203123002411 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 203123002412 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 203123002413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123002414 dimer interface [polypeptide binding]; other site 203123002415 conserved gate region; other site 203123002416 putative PBP binding loops; other site 203123002417 ABC-ATPase subunit interface; other site 203123002418 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 203123002419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 203123002420 Walker A/P-loop; other site 203123002421 ATP binding site [chemical binding]; other site 203123002422 Q-loop/lid; other site 203123002423 ABC transporter signature motif; other site 203123002424 Walker B; other site 203123002425 D-loop; other site 203123002426 H-loop/switch region; other site 203123002427 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 203123002428 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 203123002429 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 203123002430 Walker A/P-loop; other site 203123002431 ATP binding site [chemical binding]; other site 203123002432 Q-loop/lid; other site 203123002433 ABC transporter signature motif; other site 203123002434 Walker B; other site 203123002435 D-loop; other site 203123002436 H-loop/switch region; other site 203123002437 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203123002438 stage V sporulation protein B; Region: spore_V_B; TIGR02900 203123002439 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 203123002440 dipeptidase PepV; Reviewed; Region: PRK07318 203123002441 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 203123002442 active site 203123002443 metal binding site [ion binding]; metal-binding site 203123002444 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 203123002445 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 203123002446 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 203123002447 Substrate-binding site [chemical binding]; other site 203123002448 Substrate specificity [chemical binding]; other site 203123002449 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 203123002450 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 203123002451 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 203123002452 Acyltransferase family; Region: Acyl_transf_3; pfam01757 203123002453 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 203123002454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123002455 Coenzyme A binding pocket [chemical binding]; other site 203123002456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 203123002457 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 203123002458 Coenzyme A binding pocket [chemical binding]; other site 203123002459 H+ Antiporter protein; Region: 2A0121; TIGR00900 203123002460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002461 putative substrate translocation pore; other site 203123002462 Uncharacterized conserved protein [Function unknown]; Region: COG2966 203123002463 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 203123002464 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 203123002465 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 203123002466 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 203123002467 Predicted flavoprotein [General function prediction only]; Region: COG0431 203123002468 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 203123002469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002470 putative substrate translocation pore; other site 203123002471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002472 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 203123002473 DNA binding residues [nucleotide binding] 203123002474 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 203123002475 putative dimer interface [polypeptide binding]; other site 203123002476 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 203123002477 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203123002478 active site 203123002479 metal binding site [ion binding]; metal-binding site 203123002480 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 203123002481 catalytic residues [active] 203123002482 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 203123002483 FemAB family; Region: FemAB; pfam02388 203123002484 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 203123002485 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 203123002486 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 203123002487 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 203123002488 Histidine kinase; Region: His_kinase; pfam06580 203123002489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123002490 ATP binding site [chemical binding]; other site 203123002491 Mg2+ binding site [ion binding]; other site 203123002492 G-X-G motif; other site 203123002493 two-component response regulator; Provisional; Region: PRK14084 203123002494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123002495 active site 203123002496 phosphorylation site [posttranslational modification] 203123002497 intermolecular recognition site; other site 203123002498 dimerization interface [polypeptide binding]; other site 203123002499 LytTr DNA-binding domain; Region: LytTR; smart00850 203123002500 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 203123002501 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 203123002502 catalytic residues [active] 203123002503 dimer interface [polypeptide binding]; other site 203123002504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123002505 Walker A/P-loop; other site 203123002506 ATP binding site [chemical binding]; other site 203123002507 Q-loop/lid; other site 203123002508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123002509 ABC transporter signature motif; other site 203123002510 Walker B; other site 203123002511 D-loop; other site 203123002512 H-loop/switch region; other site 203123002513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123002514 AAA domain; Region: AAA_21; pfam13304 203123002515 Walker A/P-loop; other site 203123002516 ATP binding site [chemical binding]; other site 203123002517 Q-loop/lid; other site 203123002518 ABC transporter signature motif; other site 203123002519 Walker B; other site 203123002520 D-loop; other site 203123002521 H-loop/switch region; other site 203123002522 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 203123002523 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 203123002524 active site 203123002525 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 203123002526 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 203123002527 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 203123002528 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 203123002529 LemA family; Region: LemA; cl00742 203123002530 aromatic amino acid aminotransferase; Validated; Region: PRK07309 203123002531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203123002532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123002533 homodimer interface [polypeptide binding]; other site 203123002534 catalytic residue [active] 203123002535 aromatic amino acid aminotransferase; Validated; Region: PRK07309 203123002536 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 203123002537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123002538 homodimer interface [polypeptide binding]; other site 203123002539 catalytic residue [active] 203123002540 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 203123002541 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203123002542 active site 203123002543 nucleotide binding site [chemical binding]; other site 203123002544 HIGH motif; other site 203123002545 KMSKS motif; other site 203123002546 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 203123002547 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 203123002548 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203123002549 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203123002550 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 203123002551 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 203123002552 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 203123002553 active site 203123002554 HIGH motif; other site 203123002555 KMSK motif region; other site 203123002556 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 203123002557 tRNA binding surface [nucleotide binding]; other site 203123002558 anticodon binding site; other site 203123002559 Transglycosylase; Region: Transgly; pfam00912 203123002560 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 203123002561 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 203123002562 Protein of unknown function (DUF964); Region: DUF964; cl01483 203123002563 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 203123002564 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203123002565 active site 203123002566 metal binding site [ion binding]; metal-binding site 203123002567 DNA binding site [nucleotide binding] 203123002568 AAA domain; Region: AAA_23; pfam13476 203123002569 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 203123002570 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 203123002571 generic binding surface I; other site 203123002572 generic binding surface II; other site 203123002573 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 203123002574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203123002575 Zn2+ binding site [ion binding]; other site 203123002576 Mg2+ binding site [ion binding]; other site 203123002577 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 203123002578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123002579 active site 203123002580 motif I; other site 203123002581 motif II; other site 203123002582 GTPase YqeH; Provisional; Region: PRK13796 203123002583 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 203123002584 GTP/Mg2+ binding site [chemical binding]; other site 203123002585 G4 box; other site 203123002586 G5 box; other site 203123002587 G1 box; other site 203123002588 Switch I region; other site 203123002589 G2 box; other site 203123002590 G3 box; other site 203123002591 Switch II region; other site 203123002592 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 203123002593 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 203123002594 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 203123002595 active site 203123002596 (T/H)XGH motif; other site 203123002597 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203123002598 Zn2+ binding site [ion binding]; other site 203123002599 Mg2+ binding site [ion binding]; other site 203123002600 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 203123002601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123002602 S-adenosylmethionine binding site [chemical binding]; other site 203123002603 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 203123002604 hypothetical protein; Provisional; Region: PRK13670 203123002605 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 203123002606 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 203123002607 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 203123002608 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 203123002609 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 203123002610 Predicted transcriptional regulators [Transcription]; Region: COG1733 203123002611 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 203123002612 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 203123002613 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 203123002614 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 203123002615 dimer interface [polypeptide binding]; other site 203123002616 motif 1; other site 203123002617 active site 203123002618 motif 2; other site 203123002619 motif 3; other site 203123002620 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 203123002621 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 203123002622 putative tRNA-binding site [nucleotide binding]; other site 203123002623 B3/4 domain; Region: B3_4; pfam03483 203123002624 tRNA synthetase B5 domain; Region: B5; smart00874 203123002625 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 203123002626 dimer interface [polypeptide binding]; other site 203123002627 motif 1; other site 203123002628 motif 3; other site 203123002629 motif 2; other site 203123002630 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 203123002631 Rhomboid family; Region: Rhomboid; cl11446 203123002632 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 203123002633 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 203123002634 nucleotide binding site [chemical binding]; other site 203123002635 Flavin Reductases; Region: FlaRed; cl00801 203123002636 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123002637 dimerization interface [polypeptide binding]; other site 203123002638 putative DNA binding site [nucleotide binding]; other site 203123002639 putative Zn2+ binding site [ion binding]; other site 203123002640 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123002641 Coenzyme A binding pocket [chemical binding]; other site 203123002642 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 203123002643 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 203123002644 nucleotide binding site/active site [active] 203123002645 HIT family signature motif; other site 203123002646 catalytic residue [active] 203123002647 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 203123002648 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 203123002649 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 203123002650 Flavoprotein; Region: Flavoprotein; pfam02441 203123002651 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 203123002652 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 203123002653 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 203123002654 PYR/PP interface [polypeptide binding]; other site 203123002655 dimer interface [polypeptide binding]; other site 203123002656 tetramer interface [polypeptide binding]; other site 203123002657 TPP binding site [chemical binding]; other site 203123002658 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203123002659 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 203123002660 TPP-binding site [chemical binding]; other site 203123002661 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 203123002662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123002663 putative substrate translocation pore; other site 203123002664 short chain dehydrogenase; Provisional; Region: PRK07041 203123002665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123002666 NAD(P) binding site [chemical binding]; other site 203123002667 active site 203123002668 argininosuccinate synthase; Provisional; Region: PRK13820 203123002669 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 203123002670 ANP binding site [chemical binding]; other site 203123002671 Substrate Binding Site II [chemical binding]; other site 203123002672 Substrate Binding Site I [chemical binding]; other site 203123002673 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 203123002674 EDD domain protein, DegV family; Region: DegV; TIGR00762 203123002675 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 203123002676 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 203123002677 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 203123002678 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 203123002679 homodimer interface [polypeptide binding]; other site 203123002680 NADP binding site [chemical binding]; other site 203123002681 substrate binding site [chemical binding]; other site 203123002682 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 203123002683 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 203123002684 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 203123002685 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 203123002686 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 203123002687 nucleotide binding site [chemical binding]; other site 203123002688 homotetrameric interface [polypeptide binding]; other site 203123002689 putative phosphate binding site [ion binding]; other site 203123002690 putative allosteric binding site; other site 203123002691 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 203123002692 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 203123002693 putative catalytic cysteine [active] 203123002694 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 203123002695 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 203123002696 active site 203123002697 catalytic site [active] 203123002698 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 203123002699 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 203123002700 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 203123002701 DNA binding residues [nucleotide binding] 203123002702 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 203123002703 putative dimer interface [polypeptide binding]; other site 203123002704 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 203123002705 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 203123002706 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 203123002707 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 203123002708 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 203123002709 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 203123002710 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 203123002711 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 203123002712 active site 203123002713 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 203123002714 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 203123002715 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 203123002716 Competence protein; Region: Competence; cl00471 203123002717 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 203123002718 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 203123002719 CAAX protease self-immunity; Region: Abi; pfam02517 203123002720 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 203123002721 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 203123002722 dimer interface [polypeptide binding]; other site 203123002723 active site 203123002724 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 203123002725 LexA repressor; Validated; Region: PRK00215 203123002726 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123002727 putative DNA binding site [nucleotide binding]; other site 203123002728 putative Zn2+ binding site [ion binding]; other site 203123002729 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 203123002730 Catalytic site [active] 203123002731 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 203123002732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 203123002733 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 203123002734 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 203123002735 putative acyl-acceptor binding pocket; other site 203123002736 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 203123002737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123002738 S-adenosylmethionine binding site [chemical binding]; other site 203123002739 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 203123002740 GIY-YIG motif/motif A; other site 203123002741 putative active site [active] 203123002742 putative metal binding site [ion binding]; other site 203123002743 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 203123002744 rRNA interaction site [nucleotide binding]; other site 203123002745 S8 interaction site; other site 203123002746 putative laminin-1 binding site; other site 203123002747 elongation factor Ts; Provisional; Region: tsf; PRK09377 203123002748 UBA/TS-N domain; Region: UBA; pfam00627 203123002749 Elongation factor TS; Region: EF_TS; pfam00889 203123002750 Elongation factor TS; Region: EF_TS; pfam00889 203123002751 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 203123002752 putative nucleotide binding site [chemical binding]; other site 203123002753 uridine monophosphate binding site [chemical binding]; other site 203123002754 homohexameric interface [polypeptide binding]; other site 203123002755 ribosome recycling factor; Reviewed; Region: frr; PRK00083 203123002756 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 203123002757 hinge region; other site 203123002758 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 203123002759 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 203123002760 catalytic residue [active] 203123002761 putative FPP diphosphate binding site; other site 203123002762 putative FPP binding hydrophobic cleft; other site 203123002763 dimer interface [polypeptide binding]; other site 203123002764 putative IPP diphosphate binding site; other site 203123002765 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 203123002766 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 203123002767 RIP metalloprotease RseP; Region: TIGR00054 203123002768 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 203123002769 active site 203123002770 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 203123002771 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 203123002772 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 203123002773 putative substrate binding region [chemical binding]; other site 203123002774 prolyl-tRNA synthetase; Provisional; Region: PRK09194 203123002775 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 203123002776 dimer interface [polypeptide binding]; other site 203123002777 motif 1; other site 203123002778 active site 203123002779 motif 2; other site 203123002780 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 203123002781 putative deacylase active site [active] 203123002782 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 203123002783 active site 203123002784 motif 3; other site 203123002785 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 203123002786 anticodon binding site; other site 203123002787 DNA polymerase III PolC; Validated; Region: polC; PRK00448 203123002788 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 203123002789 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 203123002790 generic binding surface I; other site 203123002791 generic binding surface II; other site 203123002792 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 203123002793 active site 203123002794 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 203123002795 active site 203123002796 catalytic site [active] 203123002797 substrate binding site [chemical binding]; other site 203123002798 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 203123002799 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 203123002800 Yqey-like protein; Region: YqeY; pfam09424 203123002801 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 203123002802 PhoH-like protein; Region: PhoH; pfam02562 203123002803 metal-binding heat shock protein; Provisional; Region: PRK00016 203123002804 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 203123002805 GTPase Era; Reviewed; Region: era; PRK00089 203123002806 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 203123002807 G1 box; other site 203123002808 GTP/Mg2+ binding site [chemical binding]; other site 203123002809 Switch I region; other site 203123002810 G2 box; other site 203123002811 Switch II region; other site 203123002812 G3 box; other site 203123002813 G4 box; other site 203123002814 G5 box; other site 203123002815 KH domain; Region: KH_2; pfam07650 203123002816 DNA repair protein RecO; Region: reco; TIGR00613 203123002817 Recombination protein O N terminal; Region: RecO_N; pfam11967 203123002818 Recombination protein O C terminal; Region: RecO_C; pfam02565 203123002819 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 203123002820 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 203123002821 metal binding site [ion binding]; metal-binding site 203123002822 dimer interface [polypeptide binding]; other site 203123002823 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 203123002824 motif 1; other site 203123002825 dimer interface [polypeptide binding]; other site 203123002826 active site 203123002827 motif 2; other site 203123002828 motif 3; other site 203123002829 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 203123002830 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 203123002831 DNA primase; Validated; Region: dnaG; PRK05667 203123002832 CHC2 zinc finger; Region: zf-CHC2; cl17510 203123002833 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 203123002834 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 203123002835 active site 203123002836 metal binding site [ion binding]; metal-binding site 203123002837 interdomain interaction site; other site 203123002838 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 203123002839 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 203123002840 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 203123002841 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 203123002842 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203123002843 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 203123002844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 203123002845 DNA binding residues [nucleotide binding] 203123002846 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 203123002847 Family of unknown function (DUF633); Region: DUF633; pfam04816 203123002848 peptidase T; Region: peptidase-T; TIGR01882 203123002849 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 203123002850 metal binding site [ion binding]; metal-binding site 203123002851 dimer interface [polypeptide binding]; other site 203123002852 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 203123002853 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 203123002854 active site 203123002855 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 203123002856 PHP Thumb interface [polypeptide binding]; other site 203123002857 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 203123002858 generic binding surface II; other site 203123002859 generic binding surface I; other site 203123002860 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 203123002861 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 203123002862 domain interfaces; other site 203123002863 active site 203123002864 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 203123002865 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 203123002866 active site 203123002867 Int/Topo IB signature motif; other site 203123002868 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 203123002869 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 203123002870 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 203123002871 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203123002872 RNA binding surface [nucleotide binding]; other site 203123002873 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 203123002874 active site 203123002875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123002876 cytidylate kinase; Provisional; Region: cmk; PRK00023 203123002877 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 203123002878 CMP-binding site; other site 203123002879 The sites determining sugar specificity; other site 203123002880 GTP-binding protein Der; Reviewed; Region: PRK00093 203123002881 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 203123002882 G1 box; other site 203123002883 GTP/Mg2+ binding site [chemical binding]; other site 203123002884 Switch I region; other site 203123002885 G2 box; other site 203123002886 Switch II region; other site 203123002887 G3 box; other site 203123002888 G4 box; other site 203123002889 G5 box; other site 203123002890 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 203123002891 G1 box; other site 203123002892 GTP/Mg2+ binding site [chemical binding]; other site 203123002893 Switch I region; other site 203123002894 G2 box; other site 203123002895 G3 box; other site 203123002896 Switch II region; other site 203123002897 G4 box; other site 203123002898 G5 box; other site 203123002899 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 203123002900 IHF - DNA interface [nucleotide binding]; other site 203123002901 IHF dimer interface [polypeptide binding]; other site 203123002902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 203123002903 binding surface 203123002904 TPR motif; other site 203123002905 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 203123002906 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 203123002907 active site 203123002908 NTP binding site [chemical binding]; other site 203123002909 metal binding triad [ion binding]; metal-binding site 203123002910 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 203123002911 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 203123002912 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 203123002913 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 203123002914 folate binding site [chemical binding]; other site 203123002915 NADP+ binding site [chemical binding]; other site 203123002916 EDD domain protein, DegV family; Region: DegV; TIGR00762 203123002917 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 203123002918 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 203123002919 active site 203123002920 catalytic triad [active] 203123002921 oxyanion hole [active] 203123002922 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 203123002923 hypothetical protein; Provisional; Region: PRK13672 203123002924 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 203123002925 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 203123002926 GTP/Mg2+ binding site [chemical binding]; other site 203123002927 G4 box; other site 203123002928 G5 box; other site 203123002929 G1 box; other site 203123002930 Switch I region; other site 203123002931 G2 box; other site 203123002932 G3 box; other site 203123002933 Switch II region; other site 203123002934 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 203123002935 RNA/DNA hybrid binding site [nucleotide binding]; other site 203123002936 active site 203123002937 DNA protecting protein DprA; Region: dprA; TIGR00732 203123002938 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 203123002939 DNA topoisomerase I; Validated; Region: PRK05582 203123002940 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 203123002941 active site 203123002942 interdomain interaction site; other site 203123002943 putative metal-binding site [ion binding]; other site 203123002944 nucleotide binding site [chemical binding]; other site 203123002945 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 203123002946 domain I; other site 203123002947 DNA binding groove [nucleotide binding] 203123002948 phosphate binding site [ion binding]; other site 203123002949 domain II; other site 203123002950 domain III; other site 203123002951 nucleotide binding site [chemical binding]; other site 203123002952 catalytic site [active] 203123002953 domain IV; other site 203123002954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 203123002955 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 203123002956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 203123002957 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 203123002958 active site 203123002959 DNA binding site [nucleotide binding] 203123002960 Int/Topo IB signature motif; other site 203123002961 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 203123002962 active site 203123002963 catalytic residues [active] 203123002964 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 203123002965 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 203123002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123002967 ATP binding site [chemical binding]; other site 203123002968 Mg2+ binding site [ion binding]; other site 203123002969 G-X-G motif; other site 203123002970 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 203123002971 anchoring element; other site 203123002972 dimer interface [polypeptide binding]; other site 203123002973 ATP binding site [chemical binding]; other site 203123002974 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 203123002975 active site 203123002976 putative metal-binding site [ion binding]; other site 203123002977 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 203123002978 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 203123002979 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 203123002980 CAP-like domain; other site 203123002981 active site 203123002982 primary dimer interface [polypeptide binding]; other site 203123002983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 203123002984 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 203123002985 DHH family; Region: DHH; pfam01368 203123002986 DHHA2 domain; Region: DHHA2; pfam02833 203123002987 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 203123002988 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 203123002989 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 203123002990 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 203123002991 catalytic triad [active] 203123002992 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 203123002993 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 203123002994 Sugar specificity; other site 203123002995 Pyrimidine base specificity; other site 203123002996 ATP-binding site [chemical binding]; other site 203123002997 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 203123002998 Predicted membrane protein [Function unknown]; Region: COG2261 203123002999 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 203123003000 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 203123003001 active site 203123003002 multimer interface [polypeptide binding]; other site 203123003003 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 203123003004 predicted active site [active] 203123003005 catalytic triad [active] 203123003006 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 203123003007 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 203123003008 active site 203123003009 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 203123003010 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 203123003011 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 203123003012 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 203123003013 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 203123003014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123003015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123003016 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203123003017 dimerization interface [polypeptide binding]; other site 203123003018 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 203123003019 phosphate binding site [ion binding]; other site 203123003020 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 203123003021 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 203123003022 aspartate racemase; Region: asp_race; TIGR00035 203123003023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003024 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 203123003025 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 203123003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123003027 dimer interface [polypeptide binding]; other site 203123003028 conserved gate region; other site 203123003029 ABC-ATPase subunit interface; other site 203123003030 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 203123003031 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 203123003032 Walker A/P-loop; other site 203123003033 ATP binding site [chemical binding]; other site 203123003034 Q-loop/lid; other site 203123003035 ABC transporter signature motif; other site 203123003036 Walker B; other site 203123003037 D-loop; other site 203123003038 H-loop/switch region; other site 203123003039 NIL domain; Region: NIL; pfam09383 203123003040 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 203123003041 GAF domain; Region: GAF_2; pfam13185 203123003042 Peptidase family M1; Region: Peptidase_M1; pfam01433 203123003043 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 203123003044 Zn binding site [ion binding]; other site 203123003045 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 203123003046 HicB family; Region: HicB; pfam05534 203123003047 HflC protein; Region: hflC; TIGR01932 203123003048 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 203123003049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123003050 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123003051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003052 Walker A/P-loop; other site 203123003053 ATP binding site [chemical binding]; other site 203123003054 Q-loop/lid; other site 203123003055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003056 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 203123003057 Walker A/P-loop; other site 203123003058 ATP binding site [chemical binding]; other site 203123003059 Q-loop/lid; other site 203123003060 ABC transporter signature motif; other site 203123003061 Walker B; other site 203123003062 D-loop; other site 203123003063 H-loop/switch region; other site 203123003064 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 203123003065 dipeptidase PepV; Reviewed; Region: PRK07318 203123003066 active site 203123003067 metal binding site [ion binding]; metal-binding site 203123003068 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 203123003069 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 203123003070 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123003071 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 203123003072 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 203123003073 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 203123003074 active site 203123003075 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123003076 active site 203123003077 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 203123003078 DHH family; Region: DHH; pfam01368 203123003079 DHHA1 domain; Region: DHHA1; pfam02272 203123003080 ribonuclease Z; Region: RNase_Z; TIGR02651 203123003081 GTPase CgtA; Reviewed; Region: obgE; PRK12297 203123003082 GTP1/OBG; Region: GTP1_OBG; pfam01018 203123003083 Obg GTPase; Region: Obg; cd01898 203123003084 G1 box; other site 203123003085 GTP/Mg2+ binding site [chemical binding]; other site 203123003086 Switch I region; other site 203123003087 G2 box; other site 203123003088 G3 box; other site 203123003089 Switch II region; other site 203123003090 G4 box; other site 203123003091 G5 box; other site 203123003092 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 203123003093 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 203123003094 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 203123003095 GIY-YIG motif/motif A; other site 203123003096 active site 203123003097 catalytic site [active] 203123003098 putative DNA binding site [nucleotide binding]; other site 203123003099 metal binding site [ion binding]; metal-binding site 203123003100 UvrB/uvrC motif; Region: UVR; pfam02151 203123003101 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 203123003102 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 203123003103 Transcriptional regulators [Transcription]; Region: MarR; COG1846 203123003104 MarR family; Region: MarR_2; pfam12802 203123003105 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 203123003106 Domain of unknown function (DUF814); Region: DUF814; pfam05670 203123003107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123003108 S-adenosylmethionine binding site [chemical binding]; other site 203123003109 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 203123003110 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203123003111 RNA binding surface [nucleotide binding]; other site 203123003112 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 203123003113 active site 203123003114 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 203123003115 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 203123003116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 203123003117 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 203123003118 trimer interface [polypeptide binding]; other site 203123003119 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 203123003120 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 203123003121 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 203123003122 substrate binding pocket [chemical binding]; other site 203123003123 chain length determination region; other site 203123003124 substrate-Mg2+ binding site; other site 203123003125 catalytic residues [active] 203123003126 aspartate-rich region 1; other site 203123003127 active site lid residues [active] 203123003128 aspartate-rich region 2; other site 203123003129 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 203123003130 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123003131 Walker A/P-loop; other site 203123003132 ATP binding site [chemical binding]; other site 203123003133 Q-loop/lid; other site 203123003134 ABC transporter signature motif; other site 203123003135 Walker B; other site 203123003136 D-loop; other site 203123003137 H-loop/switch region; other site 203123003138 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 203123003139 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123003140 Walker A/P-loop; other site 203123003141 ATP binding site [chemical binding]; other site 203123003142 Q-loop/lid; other site 203123003143 ABC transporter signature motif; other site 203123003144 Walker B; other site 203123003145 D-loop; other site 203123003146 H-loop/switch region; other site 203123003147 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 203123003148 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 203123003149 oligoendopeptidase F; Region: pepF; TIGR00181 203123003150 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 203123003151 Zn binding site [ion binding]; other site 203123003152 hypothetical protein; Provisional; Region: PRK13660 203123003153 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 203123003154 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 203123003155 Transglycosylase; Region: Transgly; pfam00912 203123003156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 203123003157 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 203123003158 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 203123003159 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 203123003160 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 203123003161 putative dimer interface [polypeptide binding]; other site 203123003162 putative anticodon binding site; other site 203123003163 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 203123003164 homodimer interface [polypeptide binding]; other site 203123003165 motif 1; other site 203123003166 motif 2; other site 203123003167 active site 203123003168 motif 3; other site 203123003169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 203123003170 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 203123003171 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 203123003172 active site 203123003173 catalytic site [active] 203123003174 substrate binding site [chemical binding]; other site 203123003175 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 203123003176 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 203123003177 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 203123003178 diphosphomevalonate decarboxylase; Region: PLN02407 203123003179 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 203123003180 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 203123003181 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 203123003182 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 203123003183 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 203123003184 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 203123003185 homotetramer interface [polypeptide binding]; other site 203123003186 FMN binding site [chemical binding]; other site 203123003187 homodimer contacts [polypeptide binding]; other site 203123003188 putative active site [active] 203123003189 putative substrate binding site [chemical binding]; other site 203123003190 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 203123003191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123003192 S-adenosylmethionine binding site [chemical binding]; other site 203123003193 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 203123003194 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 203123003195 active site 203123003196 catalytic triad [active] 203123003197 oxyanion hole [active] 203123003198 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 203123003199 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 203123003200 AAA domain; Region: AAA_30; pfam13604 203123003201 Family description; Region: UvrD_C_2; pfam13538 203123003202 Putative amino acid metabolism; Region: DUF1831; pfam08866 203123003203 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 203123003204 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 203123003205 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 203123003206 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 203123003207 trimerization site [polypeptide binding]; other site 203123003208 active site 203123003209 FeS assembly protein SufB; Region: sufB; TIGR01980 203123003210 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 203123003211 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 203123003212 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 203123003213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 203123003214 catalytic residue [active] 203123003215 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 203123003216 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 203123003217 FeS assembly protein SufD; Region: sufD; TIGR01981 203123003218 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 203123003219 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 203123003220 Walker A/P-loop; other site 203123003221 ATP binding site [chemical binding]; other site 203123003222 Q-loop/lid; other site 203123003223 ABC transporter signature motif; other site 203123003224 Walker B; other site 203123003225 D-loop; other site 203123003226 H-loop/switch region; other site 203123003227 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 203123003228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 203123003229 FeS/SAM binding site; other site 203123003230 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 203123003231 Class III ribonucleotide reductase; Region: RNR_III; cd01675 203123003232 effector binding site; other site 203123003233 active site 203123003234 Zn binding site [ion binding]; other site 203123003235 glycine loop; other site 203123003236 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 203123003237 arginine deiminase; Provisional; Region: PRK01388 203123003238 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 203123003239 Sulfate transporter family; Region: Sulfate_transp; pfam00916 203123003240 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123003241 catalytic core [active] 203123003242 GMP synthase; Reviewed; Region: guaA; PRK00074 203123003243 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 203123003244 AMP/PPi binding site [chemical binding]; other site 203123003245 candidate oxyanion hole; other site 203123003246 catalytic triad [active] 203123003247 potential glutamine specificity residues [chemical binding]; other site 203123003248 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 203123003249 ATP Binding subdomain [chemical binding]; other site 203123003250 Ligand Binding sites [chemical binding]; other site 203123003251 Dimerization subdomain; other site 203123003252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123003253 active site 203123003254 adenylosuccinate lyase; Provisional; Region: PRK07492 203123003255 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 203123003256 tetramer interface [polypeptide binding]; other site 203123003257 active site 203123003258 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 203123003259 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 203123003260 GDP-binding site [chemical binding]; other site 203123003261 ACT binding site; other site 203123003262 IMP binding site; other site 203123003263 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 203123003264 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 203123003265 active site 203123003266 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 203123003267 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 203123003268 purine monophosphate binding site [chemical binding]; other site 203123003269 dimer interface [polypeptide binding]; other site 203123003270 putative catalytic residues [active] 203123003271 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 203123003272 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 203123003273 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 203123003274 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 203123003275 active site 203123003276 substrate binding site [chemical binding]; other site 203123003277 cosubstrate binding site; other site 203123003278 catalytic site [active] 203123003279 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 203123003280 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 203123003281 dimerization interface [polypeptide binding]; other site 203123003282 putative ATP binding site [chemical binding]; other site 203123003283 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 203123003284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 203123003285 dimerization interface [polypeptide binding]; other site 203123003286 ATP binding site [chemical binding]; other site 203123003287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 203123003288 dimerization interface [polypeptide binding]; other site 203123003289 ATP binding site [chemical binding]; other site 203123003290 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 203123003291 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 203123003292 putative active site [active] 203123003293 catalytic triad [active] 203123003294 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 203123003295 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 203123003296 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 203123003297 ATP binding site [chemical binding]; other site 203123003298 active site 203123003299 substrate binding site [chemical binding]; other site 203123003300 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 203123003301 ATP-grasp domain; Region: ATP-grasp; pfam02222 203123003302 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 203123003303 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 203123003304 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203123003305 active site 203123003306 HIGH motif; other site 203123003307 nucleotide binding site [chemical binding]; other site 203123003308 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 203123003309 active site 203123003310 KMSKS motif; other site 203123003311 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 203123003312 tRNA binding surface [nucleotide binding]; other site 203123003313 anticodon binding site; other site 203123003314 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 203123003315 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203123003316 RNA binding surface [nucleotide binding]; other site 203123003317 YGGT family; Region: YGGT; pfam02325 203123003318 Protein of unknown function (DUF552); Region: DUF552; pfam04472 203123003319 cell division protein FtsZ; Region: ftsZ; TIGR00065 203123003320 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 203123003321 nucleotide binding site [chemical binding]; other site 203123003322 SulA interaction site; other site 203123003323 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 203123003324 Cell division protein FtsA; Region: FtsA; smart00842 203123003325 Cell division protein FtsA; Region: FtsA; pfam14450 203123003326 Cell division protein FtsQ; Region: FtsQ; pfam03799 203123003327 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 203123003328 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 203123003329 active site 203123003330 homodimer interface [polypeptide binding]; other site 203123003331 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 203123003332 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203123003333 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203123003334 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 203123003335 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 203123003336 Mg++ binding site [ion binding]; other site 203123003337 putative catalytic motif [active] 203123003338 putative substrate binding site [chemical binding]; other site 203123003339 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 203123003340 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 203123003341 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 203123003342 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 203123003343 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 203123003344 Cell division protein FtsL; Region: FtsL; cl11433 203123003345 MraW methylase family; Region: Methyltransf_5; cl17771 203123003346 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 203123003347 cell division protein MraZ; Reviewed; Region: PRK00326 203123003348 MraZ protein; Region: MraZ; pfam02381 203123003349 MraZ protein; Region: MraZ; pfam02381 203123003350 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 203123003351 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 203123003352 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 203123003353 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 203123003354 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 203123003355 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 203123003356 Domain of unknown function DUF20; Region: UPF0118; pfam01594 203123003357 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 203123003358 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 203123003359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 203123003360 active site 203123003361 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 203123003362 ATP-NAD kinase; Region: NAD_kinase; pfam01513 203123003363 oligoendopeptidase F; Region: pepF; TIGR00181 203123003364 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 203123003365 active site 203123003366 Zn binding site [ion binding]; other site 203123003367 Competence protein CoiA-like family; Region: CoiA; cl11541 203123003368 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 203123003369 hypothetical protein; Provisional; Region: PRK13678 203123003370 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 203123003371 hypothetical protein; Provisional; Region: PRK05473 203123003372 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 203123003373 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 203123003374 motif 1; other site 203123003375 active site 203123003376 motif 2; other site 203123003377 motif 3; other site 203123003378 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 203123003379 DHHA1 domain; Region: DHHA1; pfam02272 203123003380 amino acid transporter; Region: 2A0306; TIGR00909 203123003381 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 203123003382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203123003383 Ligand Binding Site [chemical binding]; other site 203123003384 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 203123003385 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 203123003386 Flavoprotein; Region: Flavoprotein; pfam02441 203123003387 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 203123003388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123003389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123003390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203123003391 dimerization interface [polypeptide binding]; other site 203123003392 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 203123003393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123003394 S-adenosylmethionine binding site [chemical binding]; other site 203123003395 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 203123003396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123003397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123003398 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 203123003399 nudix motif; other site 203123003400 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 203123003401 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 203123003402 homodimer interface [polypeptide binding]; other site 203123003403 ligand binding site [chemical binding]; other site 203123003404 NAD binding site [chemical binding]; other site 203123003405 catalytic site [active] 203123003406 putative phosphoketolase; Provisional; Region: PRK05261 203123003407 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 203123003408 TPP-binding site; other site 203123003409 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 203123003410 dimer interface [polypeptide binding]; other site 203123003411 PYR/PP interface [polypeptide binding]; other site 203123003412 TPP binding site [chemical binding]; other site 203123003413 XFP C-terminal domain; Region: XFP_C; pfam09363 203123003414 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123003415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123003416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203123003417 dimerization interface [polypeptide binding]; other site 203123003418 EDD domain protein, DegV family; Region: DegV; TIGR00762 203123003419 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 203123003420 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 203123003421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 203123003422 ABC-ATPase subunit interface; other site 203123003423 dimer interface [polypeptide binding]; other site 203123003424 putative PBP binding regions; other site 203123003425 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123003426 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 203123003427 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 203123003428 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 203123003429 metal binding site [ion binding]; metal-binding site 203123003430 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 203123003431 metal binding site 2 [ion binding]; metal-binding site 203123003432 putative DNA binding helix; other site 203123003433 metal binding site 1 [ion binding]; metal-binding site 203123003434 dimer interface [polypeptide binding]; other site 203123003435 structural Zn2+ binding site [ion binding]; other site 203123003436 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 203123003437 substrate binding site [chemical binding]; other site 203123003438 THF binding site; other site 203123003439 zinc-binding site [ion binding]; other site 203123003440 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 203123003441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 203123003442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 203123003443 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 203123003444 recombination factor protein RarA; Reviewed; Region: PRK13342 203123003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123003446 Walker A motif; other site 203123003447 ATP binding site [chemical binding]; other site 203123003448 Walker B motif; other site 203123003449 arginine finger; other site 203123003450 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 203123003451 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 203123003452 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 203123003453 Uncharacterized conserved protein [Function unknown]; Region: COG5663 203123003454 Predicted permeases [General function prediction only]; Region: COG0679 203123003455 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 203123003456 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123003457 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123003458 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 203123003459 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 203123003460 PTS system fructose IIA component; Region: EIIA-man; pfam03610 203123003461 active site 203123003462 active pocket/dimerization site; other site 203123003463 phosphorylation site [posttranslational modification] 203123003464 Class I aldolases; Region: Aldolase_Class_I; cl17187 203123003465 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 203123003466 intersubunit interface [polypeptide binding]; other site 203123003467 catalytic residue [active] 203123003468 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 203123003469 active site 203123003470 methionine cluster; other site 203123003471 phosphorylation site [posttranslational modification] 203123003472 metal binding site [ion binding]; metal-binding site 203123003473 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 203123003474 active site 203123003475 P-loop; other site 203123003476 phosphorylation site [posttranslational modification] 203123003477 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 203123003478 beta-galactosidase; Region: BGL; TIGR03356 203123003479 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 203123003480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123003481 DNA-binding site [nucleotide binding]; DNA binding site 203123003482 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 203123003483 general stress protein 13; Validated; Region: PRK08059 203123003484 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 203123003485 RNA binding site [nucleotide binding]; other site 203123003486 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 203123003487 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 203123003488 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 203123003489 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 203123003490 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 203123003491 catalytic site [active] 203123003492 G-X2-G-X-G-K; other site 203123003493 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 203123003494 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 203123003495 Walker A/P-loop; other site 203123003496 ATP binding site [chemical binding]; other site 203123003497 Q-loop/lid; other site 203123003498 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 203123003499 Q-loop/lid; other site 203123003500 ABC transporter signature motif; other site 203123003501 Walker B; other site 203123003502 D-loop; other site 203123003503 H-loop/switch region; other site 203123003504 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 203123003505 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 203123003506 substrate binding pocket [chemical binding]; other site 203123003507 chain length determination region; other site 203123003508 substrate-Mg2+ binding site; other site 203123003509 catalytic residues [active] 203123003510 aspartate-rich region 1; other site 203123003511 active site lid residues [active] 203123003512 aspartate-rich region 2; other site 203123003513 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 203123003514 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 203123003515 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 203123003516 generic binding surface II; other site 203123003517 generic binding surface I; other site 203123003518 transcription antitermination factor NusB; Region: nusB; TIGR01951 203123003519 putative RNA binding site [nucleotide binding]; other site 203123003520 Asp23 family; Region: Asp23; pfam03780 203123003521 elongation factor P; Validated; Region: PRK00529 203123003522 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 203123003523 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 203123003524 RNA binding site [nucleotide binding]; other site 203123003525 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 203123003526 RNA binding site [nucleotide binding]; other site 203123003527 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 203123003528 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 203123003529 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 203123003530 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 203123003531 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 203123003532 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 203123003533 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 203123003534 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 203123003535 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 203123003536 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 203123003537 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 203123003538 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 203123003539 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 203123003540 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 203123003541 putative catalytic cysteine [active] 203123003542 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 203123003543 putative active site [active] 203123003544 metal binding site [ion binding]; metal-binding site 203123003545 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 203123003546 propionate/acetate kinase; Provisional; Region: PRK12379 203123003547 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 203123003548 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 203123003549 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 203123003550 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 203123003551 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 203123003552 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 203123003553 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 203123003554 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 203123003555 active site 203123003556 (T/H)XGH motif; other site 203123003557 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 203123003558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123003559 S-adenosylmethionine binding site [chemical binding]; other site 203123003560 cell division protein FtsW; Region: ftsW; TIGR02614 203123003561 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 203123003562 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 203123003563 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 203123003564 acyl-activating enzyme (AAE) consensus motif; other site 203123003565 acyl-activating enzyme (AAE) consensus motif; other site 203123003566 putative AMP binding site [chemical binding]; other site 203123003567 putative active site [active] 203123003568 putative CoA binding site [chemical binding]; other site 203123003569 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 203123003570 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 203123003571 G1 box; other site 203123003572 putative GEF interaction site [polypeptide binding]; other site 203123003573 GTP/Mg2+ binding site [chemical binding]; other site 203123003574 Switch I region; other site 203123003575 G2 box; other site 203123003576 G3 box; other site 203123003577 Switch II region; other site 203123003578 G4 box; other site 203123003579 G5 box; other site 203123003580 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 203123003581 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 203123003582 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 203123003583 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 203123003584 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 203123003585 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203123003586 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203123003587 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 203123003588 putative tRNA-binding site [nucleotide binding]; other site 203123003589 Predicted small secreted protein [Function unknown]; Region: COG5584 203123003590 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 203123003591 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 203123003592 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 203123003593 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 203123003594 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 203123003595 Walker A/P-loop; other site 203123003596 ATP binding site [chemical binding]; other site 203123003597 Q-loop/lid; other site 203123003598 ABC transporter signature motif; other site 203123003599 Walker B; other site 203123003600 D-loop; other site 203123003601 H-loop/switch region; other site 203123003602 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 203123003603 HIT family signature motif; other site 203123003604 catalytic residue [active] 203123003605 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 203123003606 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 203123003607 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 203123003608 23S rRNA binding site [nucleotide binding]; other site 203123003609 L21 binding site [polypeptide binding]; other site 203123003610 L13 binding site [polypeptide binding]; other site 203123003611 HeH/LEM domain; Region: HeH; pfam12949 203123003612 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 203123003613 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 203123003614 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 203123003615 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 203123003616 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 203123003617 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 203123003618 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 203123003619 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 203123003620 16S/18S rRNA binding site [nucleotide binding]; other site 203123003621 S13e-L30e interaction site [polypeptide binding]; other site 203123003622 25S rRNA binding site [nucleotide binding]; other site 203123003623 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 203123003624 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 203123003625 DEAD-like helicases superfamily; Region: DEXDc; smart00487 203123003626 ATP binding site [chemical binding]; other site 203123003627 Mg++ binding site [ion binding]; other site 203123003628 motif III; other site 203123003629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123003630 nucleotide binding region [chemical binding]; other site 203123003631 ATP-binding site [chemical binding]; other site 203123003632 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 203123003633 DHH family; Region: DHH; pfam01368 203123003634 DHHA1 domain; Region: DHHA1; pfam02272 203123003635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 203123003636 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 203123003637 Preprotein translocase subunit; Region: YajC; cl00806 203123003638 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 203123003639 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 203123003640 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 203123003641 alcohol dehydrogenase; Provisional; Region: PTZ00354 203123003642 putative NAD(P) binding site [chemical binding]; other site 203123003643 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 203123003644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123003645 catalytic core [active] 203123003646 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 203123003647 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 203123003648 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 203123003649 homodimer interface [polypeptide binding]; other site 203123003650 substrate-cofactor binding pocket; other site 203123003651 catalytic residue [active] 203123003652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123003653 putative Zn2+ binding site [ion binding]; other site 203123003654 putative DNA binding site [nucleotide binding]; other site 203123003655 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 203123003656 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 203123003657 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 203123003658 NAD(P) binding site [chemical binding]; other site 203123003659 catalytic residues [active] 203123003660 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 203123003661 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 203123003662 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123003663 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 203123003664 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 203123003665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123003666 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 203123003667 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 203123003668 nucleoside/Zn binding site; other site 203123003669 dimer interface [polypeptide binding]; other site 203123003670 catalytic motif [active] 203123003671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 203123003672 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 203123003673 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 203123003674 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 203123003675 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 203123003676 HSP70 interaction site [polypeptide binding]; other site 203123003677 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 203123003678 substrate binding site [polypeptide binding]; other site 203123003679 dimer interface [polypeptide binding]; other site 203123003680 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 203123003681 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 203123003682 nucleotide binding site [chemical binding]; other site 203123003683 NEF interaction site [polypeptide binding]; other site 203123003684 SBD interface [polypeptide binding]; other site 203123003685 GrpE; Region: GrpE; pfam01025 203123003686 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 203123003687 dimer interface [polypeptide binding]; other site 203123003688 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 203123003689 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 203123003690 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 203123003691 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 203123003692 active site 203123003693 Riboflavin kinase; Region: Flavokinase; pfam01687 203123003694 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 203123003695 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 203123003696 RNA binding site [nucleotide binding]; other site 203123003697 active site 203123003698 elongation factor G; Reviewed; Region: PRK12739 203123003699 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 203123003700 G1 box; other site 203123003701 putative GEF interaction site [polypeptide binding]; other site 203123003702 GTP/Mg2+ binding site [chemical binding]; other site 203123003703 Switch I region; other site 203123003704 G2 box; other site 203123003705 G3 box; other site 203123003706 Switch II region; other site 203123003707 G4 box; other site 203123003708 G5 box; other site 203123003709 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 203123003710 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 203123003711 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 203123003712 30S ribosomal protein S7; Validated; Region: PRK05302 203123003713 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 203123003714 S17 interaction site [polypeptide binding]; other site 203123003715 S8 interaction site; other site 203123003716 16S rRNA interaction site [nucleotide binding]; other site 203123003717 streptomycin interaction site [chemical binding]; other site 203123003718 23S rRNA interaction site [nucleotide binding]; other site 203123003719 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 203123003720 Uncharacterized conserved protein [Function unknown]; Region: COG1739 203123003721 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 203123003722 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 203123003723 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 203123003724 DEAD/DEAH box helicase; Region: DEAD; pfam00270 203123003725 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 203123003726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123003727 nucleotide binding region [chemical binding]; other site 203123003728 ATP-binding site [chemical binding]; other site 203123003729 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 203123003730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123003731 active site 203123003732 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 203123003733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123003734 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 203123003735 NAD binding site [chemical binding]; other site 203123003736 dimer interface [polypeptide binding]; other site 203123003737 substrate binding site [chemical binding]; other site 203123003738 HTH domain; Region: HTH_11; pfam08279 203123003739 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 203123003740 FOG: CBS domain [General function prediction only]; Region: COG0517 203123003741 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 203123003742 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 203123003743 putative NAD(P) binding site [chemical binding]; other site 203123003744 putative substrate binding site [chemical binding]; other site 203123003745 catalytic Zn binding site [ion binding]; other site 203123003746 structural Zn binding site [ion binding]; other site 203123003747 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 203123003748 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 203123003749 putative active site [active] 203123003750 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 203123003751 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 203123003752 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 203123003753 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 203123003754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203123003755 Catalytic site [active] 203123003756 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203123003757 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 203123003758 Transposase; Region: DDE_Tnp_ISL3; pfam01610 203123003759 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 203123003760 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 203123003761 dimer interface [polypeptide binding]; other site 203123003762 active site 203123003763 metal binding site [ion binding]; metal-binding site 203123003764 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 203123003765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123003766 DNA-binding site [nucleotide binding]; DNA binding site 203123003767 UTRA domain; Region: UTRA; pfam07702 203123003768 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 203123003769 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 203123003770 Ca binding site [ion binding]; other site 203123003771 active site 203123003772 catalytic site [active] 203123003773 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 203123003774 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 203123003775 active site turn [active] 203123003776 phosphorylation site [posttranslational modification] 203123003777 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 203123003778 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 203123003779 HPr interaction site; other site 203123003780 glycerol kinase (GK) interaction site [polypeptide binding]; other site 203123003781 active site 203123003782 phosphorylation site [posttranslational modification] 203123003783 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 203123003784 active site 203123003785 oxyanion hole [active] 203123003786 catalytic triad [active] 203123003787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123003788 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003790 Walker A/P-loop; other site 203123003791 ATP binding site [chemical binding]; other site 203123003792 Q-loop/lid; other site 203123003793 ABC transporter signature motif; other site 203123003794 Walker B; other site 203123003795 D-loop; other site 203123003796 H-loop/switch region; other site 203123003797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 203123003798 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123003799 putative Zn2+ binding site [ion binding]; other site 203123003800 putative DNA binding site [nucleotide binding]; other site 203123003801 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123003802 Coenzyme A binding pocket [chemical binding]; other site 203123003803 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 203123003804 Homeodomain-like domain; Region: HTH_23; cl17451 203123003805 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 203123003806 Predicted membrane protein [Function unknown]; Region: COG2261 203123003807 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 203123003808 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 203123003809 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 203123003810 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 203123003811 NAD(P) binding site [chemical binding]; other site 203123003812 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 203123003813 30S subunit binding site; other site 203123003814 hypothetical protein; Provisional; Region: PRK04351 203123003815 SprT homologues; Region: SprT; cl01182 203123003816 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 203123003817 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 203123003818 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203123003819 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 203123003820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123003821 motif II; other site 203123003822 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 203123003823 Acyltransferase family; Region: Acyl_transf_3; pfam01757 203123003824 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 203123003825 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 203123003826 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 203123003827 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 203123003828 acyl-activating enzyme (AAE) consensus motif; other site 203123003829 acyl-activating enzyme (AAE) consensus motif; other site 203123003830 putative AMP binding site [chemical binding]; other site 203123003831 putative active site [active] 203123003832 putative CoA binding site [chemical binding]; other site 203123003833 Uncharacterized conserved protein [Function unknown]; Region: COG1284 203123003834 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 203123003835 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 203123003836 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 203123003837 dimer interface [polypeptide binding]; other site 203123003838 substrate binding site [chemical binding]; other site 203123003839 ATP binding site [chemical binding]; other site 203123003840 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 203123003841 tetramer interfaces [polypeptide binding]; other site 203123003842 binuclear metal-binding site [ion binding]; other site 203123003843 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 203123003844 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 203123003845 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 203123003846 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 203123003847 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 203123003848 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 203123003849 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 203123003850 DNA binding site [nucleotide binding] 203123003851 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 203123003852 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 203123003853 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 203123003854 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 203123003855 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 203123003856 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 203123003857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 203123003858 RPB1 interaction site [polypeptide binding]; other site 203123003859 RPB12 interaction site [polypeptide binding]; other site 203123003860 RPB10 interaction site [polypeptide binding]; other site 203123003861 RPB11 interaction site [polypeptide binding]; other site 203123003862 RPB3 interaction site [polypeptide binding]; other site 203123003863 RPB12 interaction site [polypeptide binding]; other site 203123003864 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 203123003865 DNA-binding site [nucleotide binding]; DNA binding site 203123003866 RNA-binding motif; other site 203123003867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123003868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123003869 putative substrate translocation pore; other site 203123003870 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123003871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123003872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003873 Walker A/P-loop; other site 203123003874 ATP binding site [chemical binding]; other site 203123003875 Q-loop/lid; other site 203123003876 ABC transporter signature motif; other site 203123003877 Walker B; other site 203123003878 D-loop; other site 203123003879 H-loop/switch region; other site 203123003880 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123003881 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123003882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123003883 Walker A/P-loop; other site 203123003884 ATP binding site [chemical binding]; other site 203123003885 Q-loop/lid; other site 203123003886 ABC transporter signature motif; other site 203123003887 Walker B; other site 203123003888 D-loop; other site 203123003889 H-loop/switch region; other site 203123003890 Haemolysin-III related; Region: HlyIII; cl03831 203123003891 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 203123003892 recombinase A; Provisional; Region: recA; PRK09354 203123003893 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 203123003894 hexamer interface [polypeptide binding]; other site 203123003895 Walker A motif; other site 203123003896 ATP binding site [chemical binding]; other site 203123003897 Walker B motif; other site 203123003898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 203123003899 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 203123003900 Helix-turn-helix domain; Region: HTH_25; pfam13413 203123003901 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203123003902 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 203123003903 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203123003904 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 203123003905 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 203123003906 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 203123003907 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 203123003908 putative active site [active] 203123003909 catalytic site [active] 203123003910 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 203123003911 putative active site [active] 203123003912 catalytic site [active] 203123003913 rod shape-determining protein MreC; Provisional; Region: PRK13922 203123003914 rod shape-determining protein MreC; Region: MreC; pfam04085 203123003915 rod shape-determining protein MreB; Provisional; Region: PRK13930 203123003916 MreB and similar proteins; Region: MreB_like; cd10225 203123003917 nucleotide binding site [chemical binding]; other site 203123003918 Mg binding site [ion binding]; other site 203123003919 putative protofilament interaction site [polypeptide binding]; other site 203123003920 RodZ interaction site [polypeptide binding]; other site 203123003921 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 203123003922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203123003923 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 203123003924 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 203123003925 active site 203123003926 HIGH motif; other site 203123003927 nucleotide binding site [chemical binding]; other site 203123003928 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 203123003929 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 203123003930 active site 203123003931 KMSKS motif; other site 203123003932 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 203123003933 tRNA binding surface [nucleotide binding]; other site 203123003934 anticodon binding site; other site 203123003935 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 203123003936 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 203123003937 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 203123003938 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 203123003939 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 203123003940 RNA binding surface [nucleotide binding]; other site 203123003941 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 203123003942 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 203123003943 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 203123003944 ring oligomerisation interface [polypeptide binding]; other site 203123003945 ATP/Mg binding site [chemical binding]; other site 203123003946 stacking interactions; other site 203123003947 hinge regions; other site 203123003948 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 203123003949 oligomerisation interface [polypeptide binding]; other site 203123003950 mobile loop; other site 203123003951 roof hairpin; other site 203123003952 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 203123003953 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 203123003954 CoA binding domain; Region: CoA_binding; pfam02629 203123003955 UGMP family protein; Validated; Region: PRK09604 203123003956 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 203123003957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123003958 Coenzyme A binding pocket [chemical binding]; other site 203123003959 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 203123003960 Glycoprotease family; Region: Peptidase_M22; pfam00814 203123003961 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 203123003962 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 203123003963 NAD binding site [chemical binding]; other site 203123003964 homodimer interface [polypeptide binding]; other site 203123003965 active site 203123003966 substrate binding site [chemical binding]; other site 203123003967 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 203123003968 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 203123003969 active site 2 [active] 203123003970 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 203123003971 active site 2 [active] 203123003972 active site 1 [active] 203123003973 Predicted methyltransferases [General function prediction only]; Region: COG0313 203123003974 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 203123003975 putative SAM binding site [chemical binding]; other site 203123003976 putative homodimer interface [polypeptide binding]; other site 203123003977 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 203123003978 DNA polymerase III subunit delta'; Validated; Region: PRK08485 203123003979 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 203123003980 Protein of unknown function (DUF970); Region: DUF970; cl17525 203123003981 thymidylate kinase; Validated; Region: tmk; PRK00698 203123003982 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 203123003983 TMP-binding site; other site 203123003984 ATP-binding site [chemical binding]; other site 203123003985 recombination protein RecR; Reviewed; Region: recR; PRK00076 203123003986 RecR protein; Region: RecR; pfam02132 203123003987 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 203123003988 putative active site [active] 203123003989 putative metal-binding site [ion binding]; other site 203123003990 tetramer interface [polypeptide binding]; other site 203123003991 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 203123003992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123003993 Walker A motif; other site 203123003994 ATP binding site [chemical binding]; other site 203123003995 Walker B motif; other site 203123003996 arginine finger; other site 203123003997 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 203123003998 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 203123003999 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 203123004000 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 203123004001 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 203123004002 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203123004003 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 203123004004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123004005 motif II; other site 203123004006 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 203123004007 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 203123004008 nucleoside/Zn binding site; other site 203123004009 dimer interface [polypeptide binding]; other site 203123004010 catalytic motif [active] 203123004011 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 203123004012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123004013 S-adenosylmethionine binding site [chemical binding]; other site 203123004014 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 203123004015 peripheral dimer interface [polypeptide binding]; other site 203123004016 core dimer interface [polypeptide binding]; other site 203123004017 L10 interface [polypeptide binding]; other site 203123004018 L11 interface [polypeptide binding]; other site 203123004019 putative EF-Tu interaction site [polypeptide binding]; other site 203123004020 putative EF-G interaction site [polypeptide binding]; other site 203123004021 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 203123004022 23S rRNA interface [nucleotide binding]; other site 203123004023 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 203123004024 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 203123004025 mRNA/rRNA interface [nucleotide binding]; other site 203123004026 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 203123004027 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 203123004028 23S rRNA interface [nucleotide binding]; other site 203123004029 L7/L12 interface [polypeptide binding]; other site 203123004030 putative thiostrepton binding site; other site 203123004031 L25 interface [polypeptide binding]; other site 203123004032 GntP family permease; Region: GntP_permease; pfam02447 203123004033 fructuronate transporter; Provisional; Region: PRK10034; cl15264 203123004034 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 203123004035 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 203123004036 N- and C-terminal domain interface [polypeptide binding]; other site 203123004037 active site 203123004038 catalytic site [active] 203123004039 metal binding site [ion binding]; metal-binding site 203123004040 carbohydrate binding site [chemical binding]; other site 203123004041 ATP binding site [chemical binding]; other site 203123004042 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 203123004043 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 203123004044 putative homodimer interface [polypeptide binding]; other site 203123004045 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 203123004046 heterodimer interface [polypeptide binding]; other site 203123004047 homodimer interface [polypeptide binding]; other site 203123004048 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 203123004049 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 203123004050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 203123004051 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 203123004052 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 203123004053 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 203123004054 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 203123004055 active site 203123004056 metal binding site [ion binding]; metal-binding site 203123004057 dimerization interface [polypeptide binding]; other site 203123004058 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 203123004059 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 203123004060 Walker A/P-loop; other site 203123004061 ATP binding site [chemical binding]; other site 203123004062 Q-loop/lid; other site 203123004063 ABC transporter signature motif; other site 203123004064 Walker B; other site 203123004065 D-loop; other site 203123004066 H-loop/switch region; other site 203123004067 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 203123004068 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 203123004069 FMN binding site [chemical binding]; other site 203123004070 active site 203123004071 catalytic residues [active] 203123004072 substrate binding site [chemical binding]; other site 203123004073 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 203123004074 NlpC/P60 family; Region: NLPC_P60; cl17555 203123004075 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123004076 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 203123004077 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123004078 Surface antigen [General function prediction only]; Region: COG3942 203123004079 CHAP domain; Region: CHAP; pfam05257 203123004080 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 203123004081 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 203123004082 AAA domain; Region: AAA_18; pfam13238 203123004083 active site 203123004084 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 203123004085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 203123004086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 203123004087 ABC transporter; Region: ABC_tran_2; pfam12848 203123004088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 203123004089 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 203123004090 active site 203123004091 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 203123004092 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 203123004093 ligand binding site [chemical binding]; other site 203123004094 active site 203123004095 UGI interface [polypeptide binding]; other site 203123004096 catalytic site [active] 203123004097 Tubby C 2; Region: Tub_2; cl02043 203123004098 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 203123004099 SmpB-tmRNA interface; other site 203123004100 ribonuclease R; Region: RNase_R; TIGR02063 203123004101 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 203123004102 RNB domain; Region: RNB; pfam00773 203123004103 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 203123004104 RNA binding site [nucleotide binding]; other site 203123004105 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 203123004106 Part of AAA domain; Region: AAA_19; pfam13245 203123004107 Family description; Region: UvrD_C_2; pfam13538 203123004108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123004109 catalytic core [active] 203123004110 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123004111 FemAB family; Region: FemAB; pfam02388 203123004112 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cd00004 203123004113 active site 203123004114 catalytic site [active] 203123004115 FemAB family; Region: FemAB; pfam02388 203123004116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 203123004117 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 203123004118 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 203123004119 NADP binding site [chemical binding]; other site 203123004120 active site 203123004121 putative substrate binding site [chemical binding]; other site 203123004122 Predicted permeases [General function prediction only]; Region: COG0679 203123004123 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 203123004124 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 203123004125 NAD binding site [chemical binding]; other site 203123004126 substrate binding site [chemical binding]; other site 203123004127 homodimer interface [polypeptide binding]; other site 203123004128 active site 203123004129 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 203123004130 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 203123004131 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 203123004132 substrate binding site; other site 203123004133 tetramer interface; other site 203123004134 Fic family protein [Function unknown]; Region: COG3177 203123004135 Fic/DOC family; Region: Fic; pfam02661 203123004136 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203123004137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203123004138 active site 203123004139 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 203123004140 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203123004141 Probable Catalytic site; other site 203123004142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123004143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004144 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 203123004145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004146 Walker A/P-loop; other site 203123004147 ATP binding site [chemical binding]; other site 203123004148 Q-loop/lid; other site 203123004149 ABC transporter signature motif; other site 203123004150 Walker B; other site 203123004151 D-loop; other site 203123004152 H-loop/switch region; other site 203123004153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004154 dimer interface [polypeptide binding]; other site 203123004155 conserved gate region; other site 203123004156 putative PBP binding loops; other site 203123004157 ABC-ATPase subunit interface; other site 203123004158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 203123004159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004160 dimer interface [polypeptide binding]; other site 203123004161 conserved gate region; other site 203123004162 putative PBP binding loops; other site 203123004163 ABC-ATPase subunit interface; other site 203123004164 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 203123004165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 203123004166 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 203123004167 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 203123004168 active site 203123004169 catalytic site [active] 203123004170 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 203123004171 active site 203123004172 tetramer interface [polypeptide binding]; other site 203123004173 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 203123004174 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 203123004175 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 203123004176 active site 203123004177 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 203123004178 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 203123004179 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 203123004180 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 203123004181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004182 Walker A/P-loop; other site 203123004183 ATP binding site [chemical binding]; other site 203123004184 Q-loop/lid; other site 203123004185 ABC transporter signature motif; other site 203123004186 Walker B; other site 203123004187 D-loop; other site 203123004188 H-loop/switch region; other site 203123004189 TOBE domain; Region: TOBE_2; pfam08402 203123004190 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 203123004191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004192 dimer interface [polypeptide binding]; other site 203123004193 conserved gate region; other site 203123004194 putative PBP binding loops; other site 203123004195 ABC-ATPase subunit interface; other site 203123004196 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 203123004197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004198 dimer interface [polypeptide binding]; other site 203123004199 conserved gate region; other site 203123004200 putative PBP binding loops; other site 203123004201 ABC-ATPase subunit interface; other site 203123004202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123004203 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 203123004204 DNA-binding site [nucleotide binding]; DNA binding site 203123004205 UTRA domain; Region: UTRA; pfam07702 203123004206 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 203123004207 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 203123004208 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 203123004209 Na binding site [ion binding]; other site 203123004210 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 203123004211 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 203123004212 substrate binding site [chemical binding]; other site 203123004213 ATP binding site [chemical binding]; other site 203123004214 conserved hypothetical integral membrane protein; Region: TIGR03766 203123004215 conserved hypothetical integral membrane protein; Region: TIGR03766 203123004216 6-pyruvoyl tetrahydropterin synthase-related domain; Region: 6_pyr_pter_rel; TIGR03112 203123004217 putative glycosyltransferase, exosortase G-associated; Region: glyc2_xrt_Gpos1; TIGR03111 203123004218 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 203123004219 DXD motif; other site 203123004220 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 203123004221 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 203123004222 fructuronate transporter; Provisional; Region: PRK10034; cl15264 203123004223 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 203123004224 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 203123004225 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 203123004226 TPP-binding site [chemical binding]; other site 203123004227 dimer interface [polypeptide binding]; other site 203123004228 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 203123004229 PYR/PP interface [polypeptide binding]; other site 203123004230 dimer interface [polypeptide binding]; other site 203123004231 TPP binding site [chemical binding]; other site 203123004232 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 203123004233 active site 203123004234 P-loop; other site 203123004235 phosphorylation site [posttranslational modification] 203123004236 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 203123004237 active site 203123004238 phosphorylation site [posttranslational modification] 203123004239 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 203123004240 PRD domain; Region: PRD; pfam00874 203123004241 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 203123004242 active site 203123004243 P-loop; other site 203123004244 phosphorylation site [posttranslational modification] 203123004245 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 203123004246 active site 203123004247 phosphorylation site [posttranslational modification] 203123004248 SH3-like domain; Region: SH3_8; pfam13457 203123004249 SH3-like domain; Region: SH3_8; pfam13457 203123004250 SH3-like domain; Region: SH3_8; pfam13457 203123004251 SH3-like domain; Region: SH3_8; pfam13457 203123004252 SH3-like domain; Region: SH3_8; pfam13457 203123004253 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 203123004254 Amidase; Region: Amidase; cl11426 203123004255 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 203123004256 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 203123004257 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 203123004258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123004259 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123004260 Walker A/P-loop; other site 203123004261 ATP binding site [chemical binding]; other site 203123004262 Q-loop/lid; other site 203123004263 ABC transporter signature motif; other site 203123004264 Walker B; other site 203123004265 D-loop; other site 203123004266 H-loop/switch region; other site 203123004267 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 203123004268 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123004269 Walker A/P-loop; other site 203123004270 ATP binding site [chemical binding]; other site 203123004271 Q-loop/lid; other site 203123004272 ABC transporter signature motif; other site 203123004273 Walker B; other site 203123004274 D-loop; other site 203123004275 H-loop/switch region; other site 203123004276 Domain of unknown function DUF77; Region: DUF77; pfam01910 203123004277 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 203123004278 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 203123004279 HTH-like domain; Region: HTH_21; pfam13276 203123004280 Integrase core domain; Region: rve; pfam00665 203123004281 Integrase core domain; Region: rve_2; pfam13333 203123004282 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 203123004283 Transposase; Region: HTH_Tnp_1; pfam01527 203123004284 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 203123004285 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 203123004286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203123004287 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 203123004288 active site 203123004289 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203123004290 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 203123004291 Probable Catalytic site; other site 203123004292 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 203123004293 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 203123004294 trimer interface [polypeptide binding]; other site 203123004295 active site 203123004296 substrate binding site [chemical binding]; other site 203123004297 CoA binding site [chemical binding]; other site 203123004298 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 203123004299 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123004300 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 203123004301 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 203123004302 Bacterial sugar transferase; Region: Bac_transf; pfam02397 203123004303 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 203123004304 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 203123004305 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 203123004306 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 203123004307 Chain length determinant protein; Region: Wzz; cl15801 203123004308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123004310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004311 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004312 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004313 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 203123004314 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004315 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004316 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004317 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004318 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004319 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 203123004320 Collagen binding domain; Region: Collagen_bind; pfam05737 203123004321 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004322 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004323 Cna protein B-type domain; Region: Cna_B; pfam05738 203123004324 Collagen binding domain; Region: Collagen_bind; pfam05737 203123004325 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 203123004326 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 203123004327 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203123004328 Cellulose synthase-like protein; Region: PLN02893 203123004329 PilZ domain; Region: PilZ; pfam07238 203123004330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 203123004331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 203123004332 metal binding site [ion binding]; metal-binding site 203123004333 active site 203123004334 I-site; other site 203123004335 EAL domain; Region: EAL; pfam00563 203123004336 amidase; Provisional; Region: PRK06529 203123004337 Amidase; Region: Amidase; cl11426 203123004338 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123004339 EDD domain protein, DegV family; Region: DegV; TIGR00762 203123004340 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 203123004341 EDD domain protein, DegV family; Region: DegV; TIGR00762 203123004342 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 203123004343 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 203123004344 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 203123004345 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 203123004346 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 203123004347 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 203123004348 putative active site [active] 203123004349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123004350 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 203123004351 Walker A motif; other site 203123004352 ATP binding site [chemical binding]; other site 203123004353 Walker B motif; other site 203123004354 arginine finger; other site 203123004355 Uncharacterized conserved protein [Function unknown]; Region: COG3410 203123004356 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 203123004357 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 203123004358 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 203123004359 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 203123004360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 203123004361 non-specific DNA binding site [nucleotide binding]; other site 203123004362 salt bridge; other site 203123004363 sequence-specific DNA binding site [nucleotide binding]; other site 203123004364 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 203123004365 Phosphotransferase enzyme family; Region: APH; pfam01636 203123004366 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 203123004367 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 203123004368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004369 Walker A/P-loop; other site 203123004370 ATP binding site [chemical binding]; other site 203123004371 Q-loop/lid; other site 203123004372 ABC transporter signature motif; other site 203123004373 Walker B; other site 203123004374 D-loop; other site 203123004375 H-loop/switch region; other site 203123004376 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 203123004377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004379 putative substrate translocation pore; other site 203123004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004381 putative substrate translocation pore; other site 203123004382 Predicted membrane protein [Function unknown]; Region: COG2364 203123004383 methionine sulfoxide reductase A; Provisional; Region: PRK14054 203123004384 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 203123004385 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203123004386 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123004387 Walker A/P-loop; other site 203123004388 ATP binding site [chemical binding]; other site 203123004389 Q-loop/lid; other site 203123004390 ABC transporter signature motif; other site 203123004391 Walker B; other site 203123004392 D-loop; other site 203123004393 H-loop/switch region; other site 203123004394 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 203123004395 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 203123004396 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 203123004397 Walker A/P-loop; other site 203123004398 ATP binding site [chemical binding]; other site 203123004399 Q-loop/lid; other site 203123004400 ABC transporter signature motif; other site 203123004401 Walker B; other site 203123004402 D-loop; other site 203123004403 H-loop/switch region; other site 203123004404 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 203123004405 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 203123004406 Substrate binding site; other site 203123004407 Mg++ binding site; other site 203123004408 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 203123004409 active site 203123004410 substrate binding site [chemical binding]; other site 203123004411 CoA binding site [chemical binding]; other site 203123004412 pur operon repressor; Provisional; Region: PRK09213 203123004413 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 203123004414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123004415 active site 203123004416 aspartate kinase; Reviewed; Region: PRK09034 203123004417 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 203123004418 putative catalytic residues [active] 203123004419 putative nucleotide binding site [chemical binding]; other site 203123004420 putative aspartate binding site [chemical binding]; other site 203123004421 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 203123004422 allosteric regulatory residue; other site 203123004423 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 203123004424 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 203123004425 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 203123004426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123004427 catalytic residue [active] 203123004428 homoserine dehydrogenase; Provisional; Region: PRK06349 203123004429 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 203123004430 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 203123004431 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 203123004432 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 203123004433 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 203123004434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123004435 S-adenosylmethionine binding site [chemical binding]; other site 203123004436 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 203123004437 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 203123004438 putative active site [active] 203123004439 putative metal binding site [ion binding]; other site 203123004440 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 203123004441 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 203123004442 active site 203123004443 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 203123004444 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123004445 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 203123004446 NAD binding site [chemical binding]; other site 203123004447 dimer interface [polypeptide binding]; other site 203123004448 substrate binding site [chemical binding]; other site 203123004449 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123004450 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123004451 active site 203123004452 catalytic tetrad [active] 203123004453 methionine sulfoxide reductase B; Provisional; Region: PRK00222 203123004454 SelR domain; Region: SelR; pfam01641 203123004455 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 203123004456 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 203123004457 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 203123004458 Putative esterase; Region: Esterase; pfam00756 203123004459 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 203123004460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123004461 active site 203123004462 motif I; other site 203123004463 motif II; other site 203123004464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123004465 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 203123004466 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 203123004467 active site 203123004468 HIGH motif; other site 203123004469 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 203123004470 KMSKS motif; other site 203123004471 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 203123004472 tRNA binding surface [nucleotide binding]; other site 203123004473 anticodon binding site; other site 203123004474 short chain dehydrogenase; Validated; Region: PRK06182 203123004475 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 203123004476 NADP binding site [chemical binding]; other site 203123004477 active site 203123004478 steroid binding site; other site 203123004479 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 203123004480 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 203123004481 S-ribosylhomocysteinase; Provisional; Region: PRK02260 203123004482 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 203123004483 malate dehydrogenase; Provisional; Region: PRK13529 203123004484 Malic enzyme, N-terminal domain; Region: malic; pfam00390 203123004485 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 203123004486 NAD(P) binding site [chemical binding]; other site 203123004487 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123004488 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123004489 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 203123004490 dimerization interface [polypeptide binding]; other site 203123004491 Uncharacterized conserved protein [Function unknown]; Region: COG3402 203123004492 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 203123004493 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 203123004494 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 203123004495 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 203123004496 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 203123004497 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123004498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 203123004500 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 203123004501 substrate binding pocket [chemical binding]; other site 203123004502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123004504 putative substrate translocation pore; other site 203123004505 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 203123004506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004507 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 203123004508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 203123004509 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 203123004510 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 203123004511 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 203123004512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 203123004513 active site 203123004514 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 203123004515 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 203123004516 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 203123004517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123004518 S-adenosylmethionine binding site [chemical binding]; other site 203123004519 peptide chain release factor 1; Validated; Region: prfA; PRK00591 203123004520 This domain is found in peptide chain release factors; Region: PCRF; smart00937 203123004521 RF-1 domain; Region: RF-1; pfam00472 203123004522 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 203123004523 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 203123004524 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 203123004525 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 203123004526 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 203123004527 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 203123004528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 203123004529 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 203123004530 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 203123004531 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 203123004532 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 203123004533 carboxyltransferase (CT) interaction site; other site 203123004534 biotinylation site [posttranslational modification]; other site 203123004535 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 203123004536 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 203123004537 dimer interface [polypeptide binding]; other site 203123004538 active site 203123004539 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 203123004540 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 203123004541 NAD(P) binding site [chemical binding]; other site 203123004542 homotetramer interface [polypeptide binding]; other site 203123004543 homodimer interface [polypeptide binding]; other site 203123004544 active site 203123004545 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 203123004546 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 203123004547 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 203123004548 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 203123004549 FMN binding site [chemical binding]; other site 203123004550 substrate binding site [chemical binding]; other site 203123004551 putative catalytic residue [active] 203123004552 acyl carrier protein; Provisional; Region: acpP; PRK00982 203123004553 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 203123004554 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 203123004555 dimer interface [polypeptide binding]; other site 203123004556 active site 203123004557 CoA binding pocket [chemical binding]; other site 203123004558 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123004559 MarR family; Region: MarR_2; pfam12802 203123004560 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 203123004561 Biotin operon repressor [Transcription]; Region: BirA; COG1654 203123004562 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 203123004563 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 203123004564 BioY family; Region: BioY; pfam02632 203123004565 thymidine kinase; Provisional; Region: PRK04296 203123004566 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 203123004567 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203123004568 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 203123004569 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 203123004570 catalytic triad [active] 203123004571 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 203123004572 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 203123004573 ApbE family; Region: ApbE; pfam02424 203123004574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123004575 acetoin reductases; Region: 23BDH; TIGR02415 203123004576 NAD(P) binding site [chemical binding]; other site 203123004577 active site 203123004578 pantothenate kinase; Provisional; Region: PRK05439 203123004579 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 203123004580 active site 203123004581 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 203123004582 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 203123004583 active site 203123004584 metal binding site [ion binding]; metal-binding site 203123004585 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 203123004586 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 203123004587 ligand binding site [chemical binding]; other site 203123004588 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 203123004589 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 203123004590 Walker A/P-loop; other site 203123004591 ATP binding site [chemical binding]; other site 203123004592 Q-loop/lid; other site 203123004593 ABC transporter signature motif; other site 203123004594 Walker B; other site 203123004595 D-loop; other site 203123004596 H-loop/switch region; other site 203123004597 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 203123004598 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 203123004599 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 203123004600 TM-ABC transporter signature motif; other site 203123004601 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 203123004602 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 203123004603 TM-ABC transporter signature motif; other site 203123004604 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 203123004605 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 203123004606 peptide binding site [polypeptide binding]; other site 203123004607 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 203123004608 tetramer (dimer of dimers) interface [polypeptide binding]; other site 203123004609 active site 203123004610 dimer interface [polypeptide binding]; other site 203123004611 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 203123004612 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 203123004613 substrate binding site [chemical binding]; other site 203123004614 dimer interface [polypeptide binding]; other site 203123004615 ATP binding site [chemical binding]; other site 203123004616 D-ribose pyranase; Provisional; Region: PRK11797 203123004617 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 203123004618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004619 putative substrate translocation pore; other site 203123004620 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 203123004621 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 203123004622 peptide binding site [polypeptide binding]; other site 203123004623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 203123004624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004625 dimer interface [polypeptide binding]; other site 203123004626 conserved gate region; other site 203123004627 putative PBP binding loops; other site 203123004628 ABC-ATPase subunit interface; other site 203123004629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 203123004630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004631 dimer interface [polypeptide binding]; other site 203123004632 conserved gate region; other site 203123004633 putative PBP binding loops; other site 203123004634 ABC-ATPase subunit interface; other site 203123004635 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 203123004636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 203123004637 Walker A/P-loop; other site 203123004638 ATP binding site [chemical binding]; other site 203123004639 Q-loop/lid; other site 203123004640 ABC transporter signature motif; other site 203123004641 Walker B; other site 203123004642 D-loop; other site 203123004643 H-loop/switch region; other site 203123004644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203123004645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 203123004646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 203123004647 Walker A/P-loop; other site 203123004648 ATP binding site [chemical binding]; other site 203123004649 Q-loop/lid; other site 203123004650 ABC transporter signature motif; other site 203123004651 Walker B; other site 203123004652 D-loop; other site 203123004653 H-loop/switch region; other site 203123004654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 203123004655 Predicted integral membrane protein [Function unknown]; Region: COG5542 203123004656 amino acid transporter; Region: 2A0306; TIGR00909 203123004657 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 203123004658 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203123004659 catalytic residues [active] 203123004660 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 203123004661 Beta-lactamase; Region: Beta-lactamase; pfam00144 203123004662 exopolyphosphatase; Region: exo_poly_only; TIGR03706 203123004663 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 203123004664 polyphosphate kinase; Provisional; Region: PRK05443 203123004665 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 203123004666 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 203123004667 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 203123004668 putative domain interface [polypeptide binding]; other site 203123004669 putative active site [active] 203123004670 catalytic site [active] 203123004671 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 203123004672 putative active site [active] 203123004673 catalytic site [active] 203123004674 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 203123004675 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 203123004676 active site 203123004677 Zn binding site [ion binding]; other site 203123004678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 203123004679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004680 putative PBP binding loops; other site 203123004681 dimer interface [polypeptide binding]; other site 203123004682 ABC-ATPase subunit interface; other site 203123004683 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203123004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004685 dimer interface [polypeptide binding]; other site 203123004686 conserved gate region; other site 203123004687 putative PBP binding loops; other site 203123004688 ABC-ATPase subunit interface; other site 203123004689 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 203123004690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 203123004691 substrate binding pocket [chemical binding]; other site 203123004692 membrane-bound complex binding site; other site 203123004693 hinge residues; other site 203123004694 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 203123004695 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 203123004696 Walker A/P-loop; other site 203123004697 ATP binding site [chemical binding]; other site 203123004698 Q-loop/lid; other site 203123004699 ABC transporter signature motif; other site 203123004700 Walker B; other site 203123004701 D-loop; other site 203123004702 H-loop/switch region; other site 203123004703 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123004704 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123004705 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 203123004706 Walker A/P-loop; other site 203123004707 ATP binding site [chemical binding]; other site 203123004708 Q-loop/lid; other site 203123004709 ABC transporter signature motif; other site 203123004710 Walker B; other site 203123004711 D-loop; other site 203123004712 H-loop/switch region; other site 203123004713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123004714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123004715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004716 Walker A/P-loop; other site 203123004717 ATP binding site [chemical binding]; other site 203123004718 Q-loop/lid; other site 203123004719 ABC transporter signature motif; other site 203123004720 Walker B; other site 203123004721 D-loop; other site 203123004722 H-loop/switch region; other site 203123004723 Amino acid permease; Region: AA_permease_2; pfam13520 203123004724 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 203123004725 active site 203123004726 PemK-like protein; Region: PemK; pfam02452 203123004727 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 203123004728 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 203123004729 active site 203123004730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 203123004731 dimer interface [polypeptide binding]; other site 203123004732 substrate binding site [chemical binding]; other site 203123004733 catalytic residues [active] 203123004734 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 203123004735 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 203123004736 DEAD-like helicases superfamily; Region: DEXDc; smart00487 203123004737 ATP binding site [chemical binding]; other site 203123004738 Mg++ binding site [ion binding]; other site 203123004739 motif III; other site 203123004740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 203123004741 nucleotide binding region [chemical binding]; other site 203123004742 ATP-binding site [chemical binding]; other site 203123004743 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 203123004744 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 203123004745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 203123004746 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 203123004747 drug efflux system protein MdtG; Provisional; Region: PRK09874 203123004748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004749 putative substrate translocation pore; other site 203123004750 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203123004751 Ligand Binding Site [chemical binding]; other site 203123004752 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 203123004753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 203123004754 Soluble P-type ATPase [General function prediction only]; Region: COG4087 203123004755 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 203123004756 Penicillinase repressor; Region: Pencillinase_R; pfam03965 203123004757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 203123004758 NADH(P)-binding; Region: NAD_binding_10; pfam13460 203123004759 NAD(P) binding site [chemical binding]; other site 203123004760 active site 203123004761 enolase; Provisional; Region: eno; PRK00077 203123004762 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 203123004763 dimer interface [polypeptide binding]; other site 203123004764 metal binding site [ion binding]; metal-binding site 203123004765 substrate binding pocket [chemical binding]; other site 203123004766 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 203123004767 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 203123004768 Walker A/P-loop; other site 203123004769 ATP binding site [chemical binding]; other site 203123004770 Q-loop/lid; other site 203123004771 ABC transporter signature motif; other site 203123004772 Walker B; other site 203123004773 D-loop; other site 203123004774 H-loop/switch region; other site 203123004775 TOBE domain; Region: TOBE_2; pfam08402 203123004776 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 203123004777 triosephosphate isomerase; Provisional; Region: PRK14565 203123004778 substrate binding site [chemical binding]; other site 203123004779 dimer interface [polypeptide binding]; other site 203123004780 catalytic triad [active] 203123004781 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 203123004782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 203123004783 Uncharacterized conserved protein [Function unknown]; Region: COG1624 203123004784 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 203123004785 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 203123004786 UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179 203123004787 FAD binding domain; Region: FAD_binding_4; pfam01565 203123004788 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 203123004789 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 203123004790 active site 203123004791 putative catalytic site [active] 203123004792 DNA binding site [nucleotide binding] 203123004793 putative phosphate binding site [ion binding]; other site 203123004794 metal binding site A [ion binding]; metal-binding site 203123004795 AP binding site [nucleotide binding]; other site 203123004796 metal binding site B [ion binding]; metal-binding site 203123004797 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 203123004798 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 203123004799 active site 203123004800 catalytic site [active] 203123004801 substrate binding site [chemical binding]; other site 203123004802 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 203123004803 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 203123004804 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 203123004805 substrate binding pocket [chemical binding]; other site 203123004806 membrane-bound complex binding site; other site 203123004807 hinge residues; other site 203123004808 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123004809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004810 Walker A/P-loop; other site 203123004811 ATP binding site [chemical binding]; other site 203123004812 Q-loop/lid; other site 203123004813 ABC transporter signature motif; other site 203123004814 Walker B; other site 203123004815 D-loop; other site 203123004816 H-loop/switch region; other site 203123004817 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203123004818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004819 dimer interface [polypeptide binding]; other site 203123004820 conserved gate region; other site 203123004821 putative PBP binding loops; other site 203123004822 ABC-ATPase subunit interface; other site 203123004823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 203123004824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 203123004825 DNA binding site [nucleotide binding] 203123004826 domain linker motif; other site 203123004827 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 203123004828 putative dimerization interface [polypeptide binding]; other site 203123004829 putative ligand binding site [chemical binding]; other site 203123004830 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 203123004831 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 203123004832 NADP binding site [chemical binding]; other site 203123004833 homodimer interface [polypeptide binding]; other site 203123004834 active site 203123004835 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 203123004836 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 203123004837 putative ligand binding site [chemical binding]; other site 203123004838 putative NAD binding site [chemical binding]; other site 203123004839 catalytic site [active] 203123004840 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 203123004841 active site 203123004842 dimerization interface [polypeptide binding]; other site 203123004843 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 203123004844 TRAM domain; Region: TRAM; cl01282 203123004845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 203123004846 S-adenosylmethionine binding site [chemical binding]; other site 203123004847 putative lipid kinase; Reviewed; Region: PRK13055 203123004848 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 203123004849 Domain of unknown function (DUF1413); Region: DUF1413; pfam07205 203123004850 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 203123004851 putative deacylase active site [active] 203123004852 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 203123004853 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 203123004854 Predicted membrane protein [Function unknown]; Region: COG3601 203123004855 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 203123004856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004857 putative substrate translocation pore; other site 203123004858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004859 D-galactonate transporter; Region: 2A0114; TIGR00893 203123004860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004862 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 203123004863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 203123004864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123004865 Major Facilitator Superfamily; Region: MFS_1; pfam07690 203123004866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004867 putative substrate translocation pore; other site 203123004868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123004869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 203123004870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 203123004871 Walker A/P-loop; other site 203123004872 ATP binding site [chemical binding]; other site 203123004873 Q-loop/lid; other site 203123004874 ABC transporter signature motif; other site 203123004875 Walker B; other site 203123004876 D-loop; other site 203123004877 H-loop/switch region; other site 203123004878 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123004879 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 203123004880 NAD(P) binding site [chemical binding]; other site 203123004881 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 203123004882 Mechanosensitive ion channel; Region: MS_channel; pfam00924 203123004883 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 203123004884 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 203123004885 GatB domain; Region: GatB_Yqey; smart00845 203123004886 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 203123004887 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 203123004888 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 203123004889 hypothetical protein; Provisional; Region: PRK13662 203123004890 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 203123004891 dimer interface [polypeptide binding]; other site 203123004892 ADP-ribose binding site [chemical binding]; other site 203123004893 active site 203123004894 nudix motif; other site 203123004895 metal binding site [ion binding]; metal-binding site 203123004896 RecX family; Region: RecX; cl00936 203123004897 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 203123004898 active site 203123004899 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 203123004900 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 203123004901 Ligand binding site; other site 203123004902 Putative Catalytic site; other site 203123004903 DXD motif; other site 203123004904 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 203123004905 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 203123004906 catalytic residues [active] 203123004907 acetolactate synthase; Reviewed; Region: PRK08617 203123004908 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 203123004909 PYR/PP interface [polypeptide binding]; other site 203123004910 dimer interface [polypeptide binding]; other site 203123004911 TPP binding site [chemical binding]; other site 203123004912 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203123004913 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 203123004914 TPP-binding site [chemical binding]; other site 203123004915 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 203123004916 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 203123004917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 203123004918 active site 203123004919 metal binding site [ion binding]; metal-binding site 203123004920 Predicted membrane protein [Function unknown]; Region: COG2364 203123004921 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123004922 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 203123004923 putative NAD(P) binding site [chemical binding]; other site 203123004924 catalytic Zn binding site [ion binding]; other site 203123004925 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 203123004926 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 203123004927 nucleotide binding site [chemical binding]; other site 203123004928 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 203123004929 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 203123004930 D-lactate dehydrogenase; Validated; Region: PRK08605 203123004931 homodimer interface [polypeptide binding]; other site 203123004932 ligand binding site [chemical binding]; other site 203123004933 NAD binding site [chemical binding]; other site 203123004934 catalytic site [active] 203123004935 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 203123004936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 203123004937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123004938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004940 Walker A/P-loop; other site 203123004941 ATP binding site [chemical binding]; other site 203123004942 Q-loop/lid; other site 203123004943 ABC transporter signature motif; other site 203123004944 Walker B; other site 203123004945 D-loop; other site 203123004946 H-loop/switch region; other site 203123004947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 203123004948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 203123004949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123004950 Walker A/P-loop; other site 203123004951 ATP binding site [chemical binding]; other site 203123004952 Q-loop/lid; other site 203123004953 ABC transporter signature motif; other site 203123004954 Walker B; other site 203123004955 D-loop; other site 203123004956 H-loop/switch region; other site 203123004957 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 203123004958 myosin-cross-reactive antigen; Provisional; Region: PRK13977 203123004959 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 203123004960 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 203123004961 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 203123004962 substrate binding site [chemical binding]; other site 203123004963 THF binding site; other site 203123004964 zinc-binding site [ion binding]; other site 203123004965 hypothetical protein; Provisional; Region: PRK06446 203123004966 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 203123004967 metal binding site [ion binding]; metal-binding site 203123004968 dimer interface [polypeptide binding]; other site 203123004969 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 203123004970 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 203123004971 Walker A/P-loop; other site 203123004972 ATP binding site [chemical binding]; other site 203123004973 Q-loop/lid; other site 203123004974 ABC transporter signature motif; other site 203123004975 Walker B; other site 203123004976 D-loop; other site 203123004977 H-loop/switch region; other site 203123004978 NIL domain; Region: NIL; pfam09383 203123004979 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203123004980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123004981 dimer interface [polypeptide binding]; other site 203123004982 conserved gate region; other site 203123004983 putative PBP binding loops; other site 203123004984 ABC-ATPase subunit interface; other site 203123004985 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 203123004986 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 203123004987 active site 203123004988 catalytic residues [active] 203123004989 metal binding site [ion binding]; metal-binding site 203123004990 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 203123004991 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 203123004992 substrate binding site [chemical binding]; other site 203123004993 ligand binding site [chemical binding]; other site 203123004994 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 203123004995 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 203123004996 substrate binding site [chemical binding]; other site 203123004997 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 203123004998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123004999 DNA-binding site [nucleotide binding]; DNA binding site 203123005000 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 203123005001 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 203123005002 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 203123005003 active site 203123005004 dimer interface [polypeptide binding]; other site 203123005005 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 203123005006 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 203123005007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 203123005008 Walker A motif; other site 203123005009 ATP binding site [chemical binding]; other site 203123005010 Walker B motif; other site 203123005011 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 203123005012 trigger factor; Provisional; Region: tig; PRK01490 203123005013 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 203123005014 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 203123005015 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 203123005016 active site 203123005017 catalytic motif [active] 203123005018 Zn binding site [ion binding]; other site 203123005019 Transcriptional regulator [Transcription]; Region: LytR; COG1316 203123005020 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 203123005021 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 203123005022 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 203123005023 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 203123005024 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 203123005025 active site 203123005026 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 203123005027 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 203123005028 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 203123005029 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 203123005030 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 203123005031 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 203123005032 active site 203123005033 Chain length determinant protein; Region: Wzz; cl15801 203123005034 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 203123005035 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 203123005036 UDP-galactopyranose mutase; Region: GLF; pfam03275 203123005037 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 203123005038 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 203123005039 Probable Catalytic site; other site 203123005040 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 203123005041 Bacterial sugar transferase; Region: Bac_transf; pfam02397 203123005042 GtrA-like protein; Region: GtrA; pfam04138 203123005043 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 203123005044 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 203123005045 active site 203123005046 HIGH motif; other site 203123005047 KMSKS motif; other site 203123005048 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 203123005049 tRNA binding surface [nucleotide binding]; other site 203123005050 anticodon binding site; other site 203123005051 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 203123005052 dimer interface [polypeptide binding]; other site 203123005053 putative tRNA-binding site [nucleotide binding]; other site 203123005054 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 203123005055 Spore germination protein; Region: Spore_permease; cl17796 203123005056 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 203123005057 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 203123005058 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 203123005059 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 203123005060 dimerization interface [polypeptide binding]; other site 203123005061 DPS ferroxidase diiron center [ion binding]; other site 203123005062 ion pore; other site 203123005063 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 203123005064 Restriction endonuclease; Region: Mrr_cat; pfam04471 203123005065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 203123005066 catalytic core [active] 203123005067 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 203123005068 serine O-acetyltransferase; Region: cysE; TIGR01172 203123005069 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 203123005070 trimer interface [polypeptide binding]; other site 203123005071 active site 203123005072 substrate binding site [chemical binding]; other site 203123005073 CoA binding site [chemical binding]; other site 203123005074 cystathionine gamma-synthase/cystathionine beta-lyase; Validated; Region: PRK06176 203123005075 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 203123005076 homodimer interface [polypeptide binding]; other site 203123005077 substrate-cofactor binding pocket; other site 203123005078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123005079 catalytic residue [active] 203123005080 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 203123005081 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 203123005082 dimer interface [polypeptide binding]; other site 203123005083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 203123005084 catalytic residue [active] 203123005085 ABC transporter; Region: ABC_tran; pfam00005 203123005086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 203123005087 acetolactate synthase; Reviewed; Region: PRK08322 203123005088 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 203123005089 PYR/PP interface [polypeptide binding]; other site 203123005090 dimer interface [polypeptide binding]; other site 203123005091 TPP binding site [chemical binding]; other site 203123005092 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203123005093 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 203123005094 TPP-binding site [chemical binding]; other site 203123005095 dimer interface [polypeptide binding]; other site 203123005096 Membrane transport protein; Region: Mem_trans; cl09117 203123005097 Transcriptional regulators [Transcription]; Region: MarR; COG1846 203123005098 MarR family; Region: MarR_2; pfam12802 203123005099 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 203123005100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123005101 putative substrate translocation pore; other site 203123005102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123005103 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 203123005104 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 203123005105 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 203123005106 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 203123005107 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 203123005108 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 203123005109 dimerization interface [polypeptide binding]; other site 203123005110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 203123005111 dimer interface [polypeptide binding]; other site 203123005112 phosphorylation site [posttranslational modification] 203123005113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 203123005114 ATP binding site [chemical binding]; other site 203123005115 Mg2+ binding site [ion binding]; other site 203123005116 G-X-G motif; other site 203123005117 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 203123005118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 203123005119 active site 203123005120 phosphorylation site [posttranslational modification] 203123005121 intermolecular recognition site; other site 203123005122 dimerization interface [polypeptide binding]; other site 203123005123 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 203123005124 DNA binding site [nucleotide binding] 203123005125 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 203123005126 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 203123005127 active site 203123005128 homodimer interface [polypeptide binding]; other site 203123005129 catalytic site [active] 203123005130 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 203123005131 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 203123005132 putative NAD(P) binding site [chemical binding]; other site 203123005133 catalytic Zn binding site [ion binding]; other site 203123005134 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 203123005135 Melibiase; Region: Melibiase; pfam02065 203123005136 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123005137 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123005138 active site 203123005139 catalytic tetrad [active] 203123005140 Peptidase family C69; Region: Peptidase_C69; pfam03577 203123005141 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 203123005142 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 203123005143 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 203123005144 hinge; other site 203123005145 active site 203123005146 CTP synthetase; Validated; Region: pyrG; PRK05380 203123005147 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 203123005148 Catalytic site [active] 203123005149 active site 203123005150 UTP binding site [chemical binding]; other site 203123005151 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 203123005152 active site 203123005153 putative oxyanion hole; other site 203123005154 catalytic triad [active] 203123005155 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 203123005156 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 203123005157 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 203123005158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 203123005159 Zn2+ binding site [ion binding]; other site 203123005160 Mg2+ binding site [ion binding]; other site 203123005161 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203123005162 Ligand Binding Site [chemical binding]; other site 203123005163 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 203123005164 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 203123005165 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 203123005166 Ligand Binding Site [chemical binding]; other site 203123005167 manganese transport protein MntH; Reviewed; Region: PRK00701 203123005168 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 203123005169 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 203123005170 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 203123005171 NAD-dependent deacetylase; Provisional; Region: PRK00481 203123005172 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 203123005173 NAD+ binding site [chemical binding]; other site 203123005174 substrate binding site [chemical binding]; other site 203123005175 putative Zn binding site [ion binding]; other site 203123005176 phosphoenolpyruvate carboxylase; Provisional; Region: PRK13655 203123005177 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 203123005178 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 203123005179 helix swapped region; other site 203123005180 homodimer interface [polypeptide binding]; other site 203123005181 substrate binding pocket [chemical binding]; other site 203123005182 catalytic residues [active] 203123005183 NADH/NADPH cofactor binding site [chemical binding]; other site 203123005184 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 203123005185 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 203123005186 active site 203123005187 HIGH motif; other site 203123005188 dimer interface [polypeptide binding]; other site 203123005189 KMSKS motif; other site 203123005190 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 203123005191 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 203123005192 Walker A/P-loop; other site 203123005193 ATP binding site [chemical binding]; other site 203123005194 Q-loop/lid; other site 203123005195 ABC transporter signature motif; other site 203123005196 Walker B; other site 203123005197 D-loop; other site 203123005198 H-loop/switch region; other site 203123005199 Predicted transcriptional regulators [Transcription]; Region: COG1725 203123005200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 203123005201 DNA-binding site [nucleotide binding]; DNA binding site 203123005202 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 203123005203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 203123005204 Walker A/P-loop; other site 203123005205 ATP binding site [chemical binding]; other site 203123005206 Q-loop/lid; other site 203123005207 ABC transporter signature motif; other site 203123005208 Walker B; other site 203123005209 D-loop; other site 203123005210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 203123005211 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 203123005212 substrate binding pocket [chemical binding]; other site 203123005213 membrane-bound complex binding site; other site 203123005214 hinge residues; other site 203123005215 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 203123005216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 203123005217 dimer interface [polypeptide binding]; other site 203123005218 conserved gate region; other site 203123005219 putative PBP binding loops; other site 203123005220 ABC-ATPase subunit interface; other site 203123005221 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 203123005222 active site 203123005223 homodimer interface [polypeptide binding]; other site 203123005224 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 203123005225 Helix-turn-helix domain; Region: HTH_38; pfam13936 203123005226 Integrase core domain; Region: rve; pfam00665 203123005227 putative phosphoketolase; Provisional; Region: PRK05261 203123005228 XFP N-terminal domain; Region: XFP_N; pfam09364 203123005229 XFP C-terminal domain; Region: XFP_C; pfam09363 203123005230 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 203123005231 putative deacylase active site [active] 203123005232 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 203123005233 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 203123005234 active site 203123005235 HIGH motif; other site 203123005236 dimer interface [polypeptide binding]; other site 203123005237 KMSKS motif; other site 203123005238 S4 RNA-binding domain; Region: S4; smart00363 203123005239 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 203123005240 pyruvate oxidase; Provisional; Region: PRK08611 203123005241 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 203123005242 PYR/PP interface [polypeptide binding]; other site 203123005243 dimer interface [polypeptide binding]; other site 203123005244 tetramer interface [polypeptide binding]; other site 203123005245 TPP binding site [chemical binding]; other site 203123005246 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 203123005247 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 203123005248 TPP-binding site [chemical binding]; other site 203123005249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 203123005250 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 203123005251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 203123005252 Coenzyme A binding pocket [chemical binding]; other site 203123005253 Bacitracin resistance protein BacA; Region: BacA; pfam02673 203123005254 Transcriptional regulator [Transcription]; Region: LysR; COG0583 203123005255 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 203123005256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 203123005257 dimerization interface [polypeptide binding]; other site 203123005258 YibE/F-like protein; Region: YibE_F; cl02259 203123005259 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 203123005260 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 203123005261 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 203123005262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 203123005263 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 203123005264 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 203123005265 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 203123005266 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 203123005267 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 203123005268 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 203123005269 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 203123005270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123005271 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 203123005272 1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224 203123005273 UbiA prenyltransferase family; Region: UbiA; pfam01040 203123005274 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 203123005275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 203123005276 substrate binding pocket [chemical binding]; other site 203123005277 chain length determination region; other site 203123005278 substrate-Mg2+ binding site; other site 203123005279 catalytic residues [active] 203123005280 aspartate-rich region 1; other site 203123005281 active site lid residues [active] 203123005282 aspartate-rich region 2; other site 203123005283 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 203123005284 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 203123005285 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 203123005286 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 203123005287 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 203123005288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 203123005289 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 203123005290 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 203123005291 Protein of unknown function (DUF669); Region: DUF669; pfam05037 203123005292 CAAX protease self-immunity; Region: Abi; pfam02517 203123005293 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 203123005294 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 203123005295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 203123005296 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 203123005297 active site 203123005298 motif I; other site 203123005299 motif II; other site 203123005300 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 203123005301 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 203123005302 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 203123005303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 203123005304 putative substrate translocation pore; other site 203123005305 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 203123005306 MarR family; Region: MarR_2; pfam12802 203123005307 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 203123005308 tetramer interfaces [polypeptide binding]; other site 203123005309 binuclear metal-binding site [ion binding]; other site 203123005310 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 203123005311 CoenzymeA binding site [chemical binding]; other site 203123005312 subunit interaction site [polypeptide binding]; other site 203123005313 PHB binding site; other site 203123005314 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 203123005315 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 203123005316 active site 203123005317 catalytic tetrad [active] 203123005318 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 203123005319 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 203123005320 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 203123005321 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203123005322 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 203123005323 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 203123005324 Catalytic site [active] 203123005325 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 203123005326 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 203123005327 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 203123005328 ribonuclease P; Reviewed; Region: rnpA; PRK00499 203123005329 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399