-- dump date 20140619_224249 -- class Genbank::misc_feature -- table misc_feature_note -- id note 633147000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 633147000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 633147000003 P-loop; other site 633147000004 Magnesium ion binding site [ion binding]; other site 633147000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 633147000006 Magnesium ion binding site [ion binding]; other site 633147000007 ParB-like nuclease domain; Region: ParB; smart00470 633147000008 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 633147000009 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 633147000010 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 633147000011 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 633147000012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633147000013 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 633147000014 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633147000015 active site 633147000016 catalytic site [active] 633147000017 substrate binding site [chemical binding]; other site 633147000018 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 633147000019 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 633147000020 WYL domain; Region: WYL; pfam13280 633147000021 Predicted transcriptional regulator [Transcription]; Region: COG2378 633147000022 WYL domain; Region: WYL; pfam13280 633147000023 ribonuclease E; Reviewed; Region: rne; PRK10811 633147000024 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 633147000025 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 633147000026 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 633147000027 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 633147000028 putative ligand binding site [chemical binding]; other site 633147000029 putative NAD binding site [chemical binding]; other site 633147000030 catalytic site [active] 633147000031 Entner-Doudoroff aldolase; Region: eda; TIGR01182 633147000032 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 633147000033 active site 633147000034 intersubunit interface [polypeptide binding]; other site 633147000035 catalytic residue [active] 633147000036 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147000037 active site 633147000038 phosphorylation site [posttranslational modification] 633147000039 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 633147000040 active site 633147000041 P-loop; other site 633147000042 phosphorylation site [posttranslational modification] 633147000043 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633147000044 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633147000045 galactonate dehydratase; Provisional; Region: PRK14017 633147000046 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 633147000047 putative active site pocket [active] 633147000048 putative metal binding site [ion binding]; other site 633147000049 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633147000050 active site 633147000051 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 633147000052 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 633147000053 G1 box; other site 633147000054 putative GEF interaction site [polypeptide binding]; other site 633147000055 GTP/Mg2+ binding site [chemical binding]; other site 633147000056 Switch I region; other site 633147000057 G2 box; other site 633147000058 G3 box; other site 633147000059 Switch II region; other site 633147000060 G4 box; other site 633147000061 G5 box; other site 633147000062 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 633147000063 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 633147000064 hypothetical protein; Provisional; Region: PRK10578 633147000065 UPF0126 domain; Region: UPF0126; pfam03458 633147000066 UPF0126 domain; Region: UPF0126; pfam03458 633147000067 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 633147000068 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 633147000069 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 633147000070 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 633147000071 dimer interface [polypeptide binding]; other site 633147000072 ssDNA binding site [nucleotide binding]; other site 633147000073 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633147000074 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 633147000075 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 633147000076 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 633147000077 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 633147000078 replicative DNA helicase; Region: DnaB; TIGR00665 633147000079 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 633147000080 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 633147000081 Walker A motif; other site 633147000082 ATP binding site [chemical binding]; other site 633147000083 Walker B motif; other site 633147000084 DNA binding loops [nucleotide binding] 633147000085 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 633147000086 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 633147000087 GDP-binding site [chemical binding]; other site 633147000088 ACT binding site; other site 633147000089 IMP binding site; other site 633147000090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 633147000091 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147000092 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 633147000093 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 633147000094 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 633147000095 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 633147000096 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 633147000097 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 633147000098 dimer interface [polypeptide binding]; other site 633147000099 ADP-ribose binding site [chemical binding]; other site 633147000100 active site 633147000101 nudix motif; other site 633147000102 metal binding site [ion binding]; metal-binding site 633147000103 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 633147000104 dimer interface [polypeptide binding]; other site 633147000105 pyridoxal binding site [chemical binding]; other site 633147000106 ATP binding site [chemical binding]; other site 633147000107 AIR carboxylase; Region: AIRC; pfam00731 633147000108 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 633147000109 active site 633147000110 catalytic site [active] 633147000111 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 633147000112 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 633147000113 active site 633147000114 tetramer interface [polypeptide binding]; other site 633147000115 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147000116 active site 633147000117 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 633147000118 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 633147000119 dimerization interface [polypeptide binding]; other site 633147000120 putative ATP binding site [chemical binding]; other site 633147000121 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 633147000122 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 633147000123 active site 633147000124 substrate binding site [chemical binding]; other site 633147000125 cosubstrate binding site; other site 633147000126 catalytic site [active] 633147000127 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147000128 domain interaction interfaces [polypeptide binding]; other site 633147000129 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 633147000130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147000131 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 633147000132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147000133 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 633147000134 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 633147000135 NAD binding site [chemical binding]; other site 633147000136 dimer interface [polypeptide binding]; other site 633147000137 tetramer (dimer of dimers) interface [polypeptide binding]; other site 633147000138 substrate binding site [chemical binding]; other site 633147000139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147000140 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 633147000141 FeS/SAM binding site; other site 633147000142 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 633147000143 elongation factor G; Reviewed; Region: PRK12740 633147000144 G1 box; other site 633147000145 putative GEF interaction site [polypeptide binding]; other site 633147000146 GTP/Mg2+ binding site [chemical binding]; other site 633147000147 Switch I region; other site 633147000148 G2 box; other site 633147000149 G3 box; other site 633147000150 Switch II region; other site 633147000151 G4 box; other site 633147000152 G5 box; other site 633147000153 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633147000154 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633147000155 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633147000156 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 633147000157 Domain of unknown function DUF21; Region: DUF21; pfam01595 633147000158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 633147000159 Transporter associated domain; Region: CorC_HlyC; smart01091 633147000160 cyanophycin synthetase; Provisional; Region: PRK14016 633147000161 PRC-barrel domain; Region: PRC; pfam05239 633147000162 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 633147000163 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 633147000164 PRC-barrel domain; Region: PRC; pfam05239 633147000165 MgtE intracellular N domain; Region: MgtE_N; smart00924 633147000166 FOG: CBS domain [General function prediction only]; Region: COG0517 633147000167 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 633147000168 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 633147000169 active site 633147000170 intersubunit interactions; other site 633147000171 catalytic residue [active] 633147000172 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633147000173 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 633147000174 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633147000175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633147000176 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147000177 active site 633147000178 phosphorylation site [posttranslational modification] 633147000179 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 633147000180 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 633147000181 active site 633147000182 P-loop; other site 633147000183 phosphorylation site [posttranslational modification] 633147000184 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 633147000185 TPP-binding site [chemical binding]; other site 633147000186 dimer interface [polypeptide binding]; other site 633147000187 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 633147000188 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633147000189 PYR/PP interface [polypeptide binding]; other site 633147000190 dimer interface [polypeptide binding]; other site 633147000191 TPP binding site [chemical binding]; other site 633147000192 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633147000193 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 633147000194 intersubunit interface [polypeptide binding]; other site 633147000195 active site 633147000196 catalytic residue [active] 633147000197 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 633147000198 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 633147000199 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 633147000200 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 633147000201 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 633147000202 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 633147000203 nucleoside/Zn binding site; other site 633147000204 dimer interface [polypeptide binding]; other site 633147000205 catalytic motif [active] 633147000206 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633147000207 intersubunit interface [polypeptide binding]; other site 633147000208 active site 633147000209 zinc binding site [ion binding]; other site 633147000210 Na+ binding site [ion binding]; other site 633147000211 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147000212 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 633147000213 substrate binding site [chemical binding]; other site 633147000214 ATP binding site [chemical binding]; other site 633147000215 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147000216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147000217 DNA-binding site [nucleotide binding]; DNA binding site 633147000218 UTRA domain; Region: UTRA; pfam07702 633147000219 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147000220 active site 633147000221 phosphorylation site [posttranslational modification] 633147000222 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 633147000223 active site 633147000224 P-loop; other site 633147000225 phosphorylation site [posttranslational modification] 633147000226 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 633147000227 AAA domain; Region: AAA_17; pfam13207 633147000228 AAA domain; Region: AAA_33; pfam13671 633147000229 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 633147000230 hypothetical protein; Provisional; Region: PRK06815 633147000231 tetramer interface [polypeptide binding]; other site 633147000232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147000233 catalytic residue [active] 633147000234 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 633147000235 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 633147000236 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 633147000237 putative RNA binding site [nucleotide binding]; other site 633147000238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147000239 S-adenosylmethionine binding site [chemical binding]; other site 633147000240 Carbon starvation protein CstA; Region: CstA; pfam02554 633147000241 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 633147000242 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 633147000243 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 633147000244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633147000245 ATP binding site [chemical binding]; other site 633147000246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633147000247 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 633147000248 putative Mg++ binding site [ion binding]; other site 633147000249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147000250 nucleotide binding region [chemical binding]; other site 633147000251 ATP-binding site [chemical binding]; other site 633147000252 homoserine O-succinyltransferase; Provisional; Region: PRK05368 633147000253 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 633147000254 proposed active site lysine [active] 633147000255 conserved cys residue [active] 633147000256 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 633147000257 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 633147000258 active site 633147000259 metal binding site [ion binding]; metal-binding site 633147000260 homotetramer interface [polypeptide binding]; other site 633147000261 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 633147000262 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 633147000263 nucleotide binding site [chemical binding]; other site 633147000264 NEF interaction site [polypeptide binding]; other site 633147000265 SBD interface [polypeptide binding]; other site 633147000266 GrpE; Region: GrpE; pfam01025 633147000267 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 633147000268 dimer interface [polypeptide binding]; other site 633147000269 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 633147000270 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 633147000271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633147000272 HSP70 interaction site [polypeptide binding]; other site 633147000273 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633147000274 substrate binding site [polypeptide binding]; other site 633147000275 dimer interface [polypeptide binding]; other site 633147000276 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 633147000277 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633147000278 DNA binding residues [nucleotide binding] 633147000279 putative dimer interface [polypeptide binding]; other site 633147000280 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 633147000281 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 633147000282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 633147000283 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 633147000284 Clp amino terminal domain; Region: Clp_N; pfam02861 633147000285 Clp amino terminal domain; Region: Clp_N; pfam02861 633147000286 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147000287 Walker A motif; other site 633147000288 ATP binding site [chemical binding]; other site 633147000289 Walker B motif; other site 633147000290 arginine finger; other site 633147000291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147000292 Walker A motif; other site 633147000293 ATP binding site [chemical binding]; other site 633147000294 Walker B motif; other site 633147000295 arginine finger; other site 633147000296 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 633147000297 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147000298 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147000299 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147000300 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 633147000301 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 633147000302 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 633147000303 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 633147000304 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 633147000305 TilS substrate C-terminal domain; Region: TilS_C; cl17443 633147000306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147000307 active site 633147000308 FtsH Extracellular; Region: FtsH_ext; pfam06480 633147000309 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 633147000310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147000311 Walker A motif; other site 633147000312 ATP binding site [chemical binding]; other site 633147000313 Walker B motif; other site 633147000314 arginine finger; other site 633147000315 Peptidase family M41; Region: Peptidase_M41; pfam01434 633147000316 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147000317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633147000318 aspartate aminotransferase; Provisional; Region: PRK06836 633147000319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633147000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147000321 homodimer interface [polypeptide binding]; other site 633147000322 catalytic residue [active] 633147000323 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 633147000324 putative hydrolase; Validated; Region: PRK09248 633147000325 active site 633147000326 NAD-dependent deacetylase; Provisional; Region: PRK00481 633147000327 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 633147000328 NAD+ binding site [chemical binding]; other site 633147000329 substrate binding site [chemical binding]; other site 633147000330 Zn binding site [ion binding]; other site 633147000331 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 633147000332 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 633147000333 active site 633147000334 nucleophile elbow; other site 633147000335 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 633147000336 active site 633147000337 putative catalytic site [active] 633147000338 DNA binding site [nucleotide binding] 633147000339 putative phosphate binding site [ion binding]; other site 633147000340 metal binding site A [ion binding]; metal-binding site 633147000341 AP binding site [nucleotide binding]; other site 633147000342 metal binding site B [ion binding]; metal-binding site 633147000343 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 633147000344 homodecamer interface [polypeptide binding]; other site 633147000345 GTP cyclohydrolase I; Provisional; Region: PLN03044 633147000346 active site 633147000347 putative catalytic site residues [active] 633147000348 zinc binding site [ion binding]; other site 633147000349 GTP-CH-I/GFRP interaction surface; other site 633147000350 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 633147000351 dihydropteroate synthase; Region: DHPS; TIGR01496 633147000352 substrate binding pocket [chemical binding]; other site 633147000353 dimer interface [polypeptide binding]; other site 633147000354 inhibitor binding site; inhibition site 633147000355 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 633147000356 catalytic center binding site [active] 633147000357 ATP binding site [chemical binding]; other site 633147000358 Type III pantothenate kinase; Region: Pan_kinase; cl17198 633147000359 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 633147000360 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147000361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147000362 DNA-binding site [nucleotide binding]; DNA binding site 633147000363 UTRA domain; Region: UTRA; pfam07702 633147000364 triosephosphate isomerase; Provisional; Region: PRK04302 633147000365 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 633147000366 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 633147000367 active site 633147000368 P-loop; other site 633147000369 phosphorylation site [posttranslational modification] 633147000370 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633147000371 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633147000372 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 633147000373 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 633147000374 intersubunit interface [polypeptide binding]; other site 633147000375 active site 633147000376 Zn2+ binding site [ion binding]; other site 633147000377 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633147000378 intersubunit interface [polypeptide binding]; other site 633147000379 active site 633147000380 zinc binding site [ion binding]; other site 633147000381 Na+ binding site [ion binding]; other site 633147000382 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147000383 active site 633147000384 phosphorylation site [posttranslational modification] 633147000385 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633147000386 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 633147000387 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147000388 DNA-binding site [nucleotide binding]; DNA binding site 633147000389 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633147000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000391 ABC transporter signature motif; other site 633147000392 Walker B; other site 633147000393 D-loop; other site 633147000394 H-loop/switch region; other site 633147000395 peptide chain release factor 1; Validated; Region: prfA; PRK00591 633147000396 This domain is found in peptide chain release factors; Region: PCRF; smart00937 633147000397 RF-1 domain; Region: RF-1; pfam00472 633147000398 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 633147000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147000400 S-adenosylmethionine binding site [chemical binding]; other site 633147000401 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 633147000402 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 633147000403 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147000404 active site 633147000405 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 633147000406 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 633147000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147000408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147000409 putative substrate translocation pore; other site 633147000410 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 633147000411 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633147000412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147000413 DNA binding residues [nucleotide binding] 633147000414 dimerization interface [polypeptide binding]; other site 633147000415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147000416 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 633147000417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147000418 dimer interface [polypeptide binding]; other site 633147000419 phosphorylation site [posttranslational modification] 633147000420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147000421 ATP binding site [chemical binding]; other site 633147000422 Mg2+ binding site [ion binding]; other site 633147000423 G-X-G motif; other site 633147000424 Response regulator receiver domain; Region: Response_reg; pfam00072 633147000425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147000426 active site 633147000427 phosphorylation site [posttranslational modification] 633147000428 intermolecular recognition site; other site 633147000429 dimerization interface [polypeptide binding]; other site 633147000430 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 633147000431 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 633147000432 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 633147000433 ATP synthase subunit C; Region: ATP-synt_C; cl00466 633147000434 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 633147000435 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 633147000436 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 633147000437 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 633147000438 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 633147000439 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633147000440 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 633147000441 beta subunit interaction interface [polypeptide binding]; other site 633147000442 Walker A motif; other site 633147000443 ATP binding site [chemical binding]; other site 633147000444 Walker B motif; other site 633147000445 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633147000446 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 633147000447 core domain interface [polypeptide binding]; other site 633147000448 delta subunit interface [polypeptide binding]; other site 633147000449 epsilon subunit interface [polypeptide binding]; other site 633147000450 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 633147000451 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 633147000452 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 633147000453 alpha subunit interaction interface [polypeptide binding]; other site 633147000454 Walker A motif; other site 633147000455 ATP binding site [chemical binding]; other site 633147000456 Walker B motif; other site 633147000457 inhibitor binding site; inhibition site 633147000458 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 633147000459 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 633147000460 gamma subunit interface [polypeptide binding]; other site 633147000461 epsilon subunit interface [polypeptide binding]; other site 633147000462 LBP interface [polypeptide binding]; other site 633147000463 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 633147000464 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 633147000465 hinge; other site 633147000466 active site 633147000467 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 633147000468 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 633147000469 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 633147000470 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 633147000471 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 633147000472 active site 633147000473 tetramer interface; other site 633147000474 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 633147000475 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 633147000476 active site 633147000477 substrate binding site [chemical binding]; other site 633147000478 metal binding site [ion binding]; metal-binding site 633147000479 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 633147000480 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 633147000481 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 633147000482 SEC-C motif; Region: SEC-C; pfam02810 633147000483 peptide chain release factor 2; Validated; Region: prfB; PRK00578 633147000484 PCRF domain; Region: PCRF; pfam03462 633147000485 RF-1 domain; Region: RF-1; pfam00472 633147000486 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633147000487 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633147000488 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 633147000489 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 633147000490 active site 633147000491 intersubunit interactions; other site 633147000492 catalytic residue [active] 633147000493 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 633147000494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000495 Walker A/P-loop; other site 633147000496 ATP binding site [chemical binding]; other site 633147000497 Q-loop/lid; other site 633147000498 ABC transporter signature motif; other site 633147000499 Walker B; other site 633147000500 D-loop; other site 633147000501 H-loop/switch region; other site 633147000502 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 633147000503 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 633147000504 ribonuclease R; Region: RNase_R; TIGR02063 633147000505 RNB domain; Region: RNB; pfam00773 633147000506 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 633147000507 RNA binding site [nucleotide binding]; other site 633147000508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 633147000509 binding surface 633147000510 TPR motif; other site 633147000511 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 633147000512 SmpB-tmRNA interface; other site 633147000513 Rubredoxin [Energy production and conversion]; Region: COG1773 633147000514 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 633147000515 iron binding site [ion binding]; other site 633147000516 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 633147000517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633147000518 DNA binding site [nucleotide binding] 633147000519 active site 633147000520 Int/Topo IB signature motif; other site 633147000521 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633147000522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147000523 non-specific DNA binding site [nucleotide binding]; other site 633147000524 salt bridge; other site 633147000525 sequence-specific DNA binding site [nucleotide binding]; other site 633147000526 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 633147000527 active site 633147000528 NTP binding site [chemical binding]; other site 633147000529 metal binding triad [ion binding]; metal-binding site 633147000530 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 633147000531 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 633147000532 active site 633147000533 nucleophile elbow; other site 633147000534 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 633147000535 23S rRNA interface [nucleotide binding]; other site 633147000536 L3 interface [polypeptide binding]; other site 633147000537 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 633147000538 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 633147000539 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 633147000540 active site 633147000541 substrate binding site [chemical binding]; other site 633147000542 metal binding site [ion binding]; metal-binding site 633147000543 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 633147000544 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 633147000545 glutaminase active site [active] 633147000546 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633147000547 dimer interface [polypeptide binding]; other site 633147000548 active site 633147000549 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 633147000550 dimer interface [polypeptide binding]; other site 633147000551 active site 633147000552 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 633147000553 Uncharacterized conserved protein [Function unknown]; Region: COG0062 633147000554 putative carbohydrate kinase; Provisional; Region: PRK10565 633147000555 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 633147000556 putative substrate binding site [chemical binding]; other site 633147000557 putative ATP binding site [chemical binding]; other site 633147000558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 633147000559 alanine racemase; Reviewed; Region: alr; PRK00053 633147000560 active site 633147000561 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633147000562 dimer interface [polypeptide binding]; other site 633147000563 substrate binding site [chemical binding]; other site 633147000564 catalytic residues [active] 633147000565 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 633147000566 Fe-S cluster binding site [ion binding]; other site 633147000567 active site 633147000568 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 633147000569 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 633147000570 Glycoprotease family; Region: Peptidase_M22; pfam00814 633147000571 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 633147000572 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633147000573 Coenzyme A binding pocket [chemical binding]; other site 633147000574 UGMP family protein; Validated; Region: PRK09604 633147000575 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147000576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147000577 substrate binding pocket [chemical binding]; other site 633147000578 membrane-bound complex binding site; other site 633147000579 hinge residues; other site 633147000580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147000581 dimer interface [polypeptide binding]; other site 633147000582 conserved gate region; other site 633147000583 putative PBP binding loops; other site 633147000584 ABC-ATPase subunit interface; other site 633147000585 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633147000586 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633147000587 Walker A/P-loop; other site 633147000588 ATP binding site [chemical binding]; other site 633147000589 Q-loop/lid; other site 633147000590 ABC transporter signature motif; other site 633147000591 Walker B; other site 633147000592 D-loop; other site 633147000593 H-loop/switch region; other site 633147000594 hypothetical protein; Provisional; Region: PRK08262 633147000595 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 633147000596 metal binding site [ion binding]; metal-binding site 633147000597 Cupin domain; Region: Cupin_2; pfam07883 633147000598 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 633147000599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633147000600 NAD(P) binding site [chemical binding]; other site 633147000601 active site 633147000602 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 633147000603 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 633147000604 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 633147000605 tetrameric interface [polypeptide binding]; other site 633147000606 NAD binding site [chemical binding]; other site 633147000607 catalytic residues [active] 633147000608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147000609 putative substrate translocation pore; other site 633147000610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147000611 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 633147000612 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 633147000613 substrate binding site [chemical binding]; other site 633147000614 oxyanion hole (OAH) forming residues; other site 633147000615 trimer interface [polypeptide binding]; other site 633147000616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147000617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147000618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633147000619 dimerization interface [polypeptide binding]; other site 633147000620 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 633147000621 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 633147000622 active site 633147000623 NAD synthetase; Reviewed; Region: nadE; PRK02628 633147000624 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 633147000625 multimer interface [polypeptide binding]; other site 633147000626 active site 633147000627 catalytic triad [active] 633147000628 protein interface 1 [polypeptide binding]; other site 633147000629 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 633147000630 homodimer interface [polypeptide binding]; other site 633147000631 NAD binding pocket [chemical binding]; other site 633147000632 ATP binding pocket [chemical binding]; other site 633147000633 Mg binding site [ion binding]; other site 633147000634 active-site loop [active] 633147000635 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 633147000636 oligomerisation interface [polypeptide binding]; other site 633147000637 mobile loop; other site 633147000638 roof hairpin; other site 633147000639 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 633147000640 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 633147000641 ring oligomerisation interface [polypeptide binding]; other site 633147000642 ATP/Mg binding site [chemical binding]; other site 633147000643 stacking interactions; other site 633147000644 hinge regions; other site 633147000645 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 633147000646 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 633147000647 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147000648 FeS/SAM binding site; other site 633147000649 hypothetical protein; Provisional; Region: PRK10977 633147000650 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 633147000651 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 633147000652 putative kinase; Provisional; Region: PRK09954 633147000653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147000654 DNA binding residues [nucleotide binding] 633147000655 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 633147000656 substrate binding site [chemical binding]; other site 633147000657 ATP binding site [chemical binding]; other site 633147000658 phosphopentomutase; Provisional; Region: PRK05362 633147000659 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 633147000660 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633147000661 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 633147000662 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 633147000663 ligand binding site [chemical binding]; other site 633147000664 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 633147000665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000666 Walker A/P-loop; other site 633147000667 ATP binding site [chemical binding]; other site 633147000668 Q-loop/lid; other site 633147000669 ABC transporter signature motif; other site 633147000670 Walker B; other site 633147000671 D-loop; other site 633147000672 H-loop/switch region; other site 633147000673 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 633147000674 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147000675 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 633147000676 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 633147000677 TM-ABC transporter signature motif; other site 633147000678 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147000679 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 633147000680 TM-ABC transporter signature motif; other site 633147000681 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 633147000682 active site 633147000683 catalytic motif [active] 633147000684 Zn binding site [ion binding]; other site 633147000685 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 633147000686 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 633147000687 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 633147000688 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 633147000689 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 633147000690 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 633147000691 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633147000692 GTP-binding protein YchF; Reviewed; Region: PRK09601 633147000693 YchF GTPase; Region: YchF; cd01900 633147000694 G1 box; other site 633147000695 GTP/Mg2+ binding site [chemical binding]; other site 633147000696 Switch I region; other site 633147000697 G2 box; other site 633147000698 Switch II region; other site 633147000699 G3 box; other site 633147000700 G4 box; other site 633147000701 G5 box; other site 633147000702 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 633147000703 Transcriptional regulator [Transcription]; Region: LytR; COG1316 633147000704 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 633147000705 Transcriptional regulator [Transcription]; Region: LytR; COG1316 633147000706 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 633147000707 GMP synthase; Reviewed; Region: guaA; PRK00074 633147000708 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 633147000709 AMP/PPi binding site [chemical binding]; other site 633147000710 candidate oxyanion hole; other site 633147000711 catalytic triad [active] 633147000712 potential glutamine specificity residues [chemical binding]; other site 633147000713 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 633147000714 ATP Binding subdomain [chemical binding]; other site 633147000715 Ligand Binding sites [chemical binding]; other site 633147000716 Dimerization subdomain; other site 633147000717 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 633147000718 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 633147000719 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633147000720 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 633147000721 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 633147000722 AAA ATPase domain; Region: AAA_15; pfam13175 633147000723 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 633147000724 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 633147000725 TIGR04076 family protein; Region: TIGR04076 633147000726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 633147000727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 633147000728 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 633147000729 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147000730 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 633147000731 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147000732 Walker A/P-loop; other site 633147000733 ATP binding site [chemical binding]; other site 633147000734 Q-loop/lid; other site 633147000735 ABC transporter signature motif; other site 633147000736 Walker B; other site 633147000737 D-loop; other site 633147000738 H-loop/switch region; other site 633147000739 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000740 Walker A/P-loop; other site 633147000741 ATP binding site [chemical binding]; other site 633147000742 Q-loop/lid; other site 633147000743 ABC transporter signature motif; other site 633147000744 Walker B; other site 633147000745 D-loop; other site 633147000746 H-loop/switch region; other site 633147000747 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147000748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147000749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000750 Walker A/P-loop; other site 633147000751 ATP binding site [chemical binding]; other site 633147000752 Q-loop/lid; other site 633147000753 ABC transporter signature motif; other site 633147000754 Walker B; other site 633147000755 D-loop; other site 633147000756 H-loop/switch region; other site 633147000757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147000758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147000759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000760 Walker A/P-loop; other site 633147000761 ATP binding site [chemical binding]; other site 633147000762 Q-loop/lid; other site 633147000763 ABC transporter signature motif; other site 633147000764 Walker B; other site 633147000765 D-loop; other site 633147000766 H-loop/switch region; other site 633147000767 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147000768 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 633147000769 Walker A/P-loop; other site 633147000770 ATP binding site [chemical binding]; other site 633147000771 Q-loop/lid; other site 633147000772 ABC transporter signature motif; other site 633147000773 Walker B; other site 633147000774 D-loop; other site 633147000775 H-loop/switch region; other site 633147000776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147000777 Walker A/P-loop; other site 633147000778 ATP binding site [chemical binding]; other site 633147000779 Q-loop/lid; other site 633147000780 ABC transporter signature motif; other site 633147000781 Walker B; other site 633147000782 D-loop; other site 633147000783 H-loop/switch region; other site 633147000784 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147000785 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 633147000786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147000787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147000788 Fic family protein [Function unknown]; Region: COG3177 633147000789 Fic/DOC family; Region: Fic; pfam02661 633147000790 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 633147000791 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 633147000792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147000793 S-adenosylmethionine binding site [chemical binding]; other site 633147000794 RelB antitoxin; Region: RelB; cl01171 633147000795 PemK-like protein; Region: PemK; pfam02452 633147000796 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 633147000797 Uncharacterized conserved protein [Function unknown]; Region: COG5361 633147000798 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 633147000799 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 633147000800 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 633147000801 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633147000802 ABC-ATPase subunit interface; other site 633147000803 dimer interface [polypeptide binding]; other site 633147000804 putative PBP binding regions; other site 633147000805 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 633147000806 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 633147000807 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 633147000808 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 633147000809 metal binding site [ion binding]; metal-binding site 633147000810 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633147000811 catalytic core [active] 633147000812 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633147000813 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 633147000814 AAA domain; Region: AAA_14; pfam13173 633147000815 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 633147000816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 633147000817 Walker A/P-loop; other site 633147000818 ATP binding site [chemical binding]; other site 633147000819 Q-loop/lid; other site 633147000820 ABC transporter signature motif; other site 633147000821 Walker B; other site 633147000822 D-loop; other site 633147000823 H-loop/switch region; other site 633147000824 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147000825 DNA-binding site [nucleotide binding]; DNA binding site 633147000826 Predicted membrane protein [General function prediction only]; Region: COG4194 633147000827 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 633147000828 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 633147000829 putative ADP-ribose binding site [chemical binding]; other site 633147000830 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 633147000831 Predicted transcriptional regulators [Transcription]; Region: COG1733 633147000832 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 633147000833 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 633147000834 A new structural DNA glycosylase; Region: AlkD_like; cd06561 633147000835 active site 633147000836 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147000837 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 633147000838 classical (c) SDRs; Region: SDR_c; cd05233 633147000839 short chain dehydrogenase; Provisional; Region: PRK07041 633147000840 NAD(P) binding site [chemical binding]; other site 633147000841 active site 633147000842 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147000843 DNA binding residues [nucleotide binding] 633147000844 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 633147000845 Double zinc ribbon; Region: DZR; pfam12773 633147000846 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 633147000847 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 633147000848 B3/4 domain; Region: B3_4; pfam03483 633147000849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147000850 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 633147000851 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 633147000852 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 633147000853 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 633147000854 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633147000855 DNA binding residues [nucleotide binding] 633147000856 dimer interface [polypeptide binding]; other site 633147000857 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 633147000858 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 633147000859 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 633147000860 Predicted transcriptional regulators [Transcription]; Region: COG1695 633147000861 Transcriptional regulator PadR-like family; Region: PadR; cl17335 633147000862 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 633147000863 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633147000864 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 633147000865 Walker A/P-loop; other site 633147000866 ATP binding site [chemical binding]; other site 633147000867 Q-loop/lid; other site 633147000868 ABC transporter signature motif; other site 633147000869 Walker B; other site 633147000870 D-loop; other site 633147000871 H-loop/switch region; other site 633147000872 Predicted transcriptional regulators [Transcription]; Region: COG1725 633147000873 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147000874 DNA-binding site [nucleotide binding]; DNA binding site 633147000875 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 633147000876 ZIP Zinc transporter; Region: Zip; pfam02535 633147000877 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 633147000878 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 633147000879 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 633147000880 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 633147000881 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 633147000882 metal binding site 2 [ion binding]; metal-binding site 633147000883 putative DNA binding helix; other site 633147000884 metal binding site 1 [ion binding]; metal-binding site 633147000885 dimer interface [polypeptide binding]; other site 633147000886 structural Zn2+ binding site [ion binding]; other site 633147000887 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 633147000888 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 633147000889 metal binding site [ion binding]; metal-binding site 633147000890 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633147000891 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 633147000892 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 633147000893 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 633147000894 ABC-ATPase subunit interface; other site 633147000895 dimer interface [polypeptide binding]; other site 633147000896 putative PBP binding regions; other site 633147000897 Cna protein B-type domain; Region: Cna_B; pfam05738 633147000898 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 633147000899 Cna protein B-type domain; Region: Cna_B; pfam05738 633147000900 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 633147000901 active site 633147000902 catalytic site [active] 633147000903 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147000904 domain interaction interfaces [polypeptide binding]; other site 633147000905 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 633147000906 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 633147000907 tetramer interface [polypeptide binding]; other site 633147000908 catalytic Zn binding site [ion binding]; other site 633147000909 NADP binding site [chemical binding]; other site 633147000910 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 633147000911 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633147000912 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 633147000913 Pyruvate formate lyase 1; Region: PFL1; cd01678 633147000914 coenzyme A binding site [chemical binding]; other site 633147000915 active site 633147000916 catalytic residues [active] 633147000917 glycine loop; other site 633147000918 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 633147000919 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147000920 FeS/SAM binding site; other site 633147000921 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 633147000922 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 633147000923 ligand binding site [chemical binding]; other site 633147000924 flexible hinge region; other site 633147000925 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 633147000926 putative switch regulator; other site 633147000927 non-specific DNA interactions [nucleotide binding]; other site 633147000928 DNA binding site [nucleotide binding] 633147000929 sequence specific DNA binding site [nucleotide binding]; other site 633147000930 putative cAMP binding site [chemical binding]; other site 633147000931 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 633147000932 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 633147000933 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 633147000934 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 633147000935 Hexamer interface [polypeptide binding]; other site 633147000936 Hexagonal pore residue; other site 633147000937 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 633147000938 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 633147000939 Hexamer interface [polypeptide binding]; other site 633147000940 Hexagonal pore residue; other site 633147000941 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 633147000942 NAD(P) binding site [chemical binding]; other site 633147000943 catalytic residues [active] 633147000944 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 633147000945 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 633147000946 dimer interface [polypeptide binding]; other site 633147000947 active site 633147000948 glycine loop; other site 633147000949 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 633147000950 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 633147000951 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 633147000952 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 633147000953 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633147000954 nucleotide binding site [chemical binding]; other site 633147000955 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633147000956 nucleotide binding site [chemical binding]; other site 633147000957 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 633147000958 Hexamer interface [polypeptide binding]; other site 633147000959 Hexagonal pore residue; other site 633147000960 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 633147000961 Hexamer/Pentamer interface [polypeptide binding]; other site 633147000962 central pore; other site 633147000963 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 633147000964 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 633147000965 Propanediol utilisation protein PduL; Region: PduL; pfam06130 633147000966 Propanediol utilisation protein PduL; Region: PduL; pfam06130 633147000967 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 633147000968 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 633147000969 Hexamer interface [polypeptide binding]; other site 633147000970 Hexagonal pore residue; other site 633147000971 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 633147000972 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 633147000973 Hexamer interface [polypeptide binding]; other site 633147000974 Hexagonal pore residue; other site 633147000975 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 633147000976 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 633147000977 Hexamer interface [polypeptide binding]; other site 633147000978 Putative hexagonal pore residue; other site 633147000979 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 633147000980 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 633147000981 putative catalytic cysteine [active] 633147000982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 633147000983 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 633147000984 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 633147000985 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 633147000986 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 633147000987 DNA binding residues [nucleotide binding] 633147000988 drug binding residues [chemical binding]; other site 633147000989 dimer interface [polypeptide binding]; other site 633147000990 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633147000991 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 633147000992 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 633147000993 putative active site [active] 633147000994 metal binding site [ion binding]; metal-binding site 633147000995 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 633147000996 putative hexamer interface [polypeptide binding]; other site 633147000997 putative hexagonal pore; other site 633147000998 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 633147000999 putative hexamer interface [polypeptide binding]; other site 633147001000 putative hexagonal pore; other site 633147001001 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 633147001002 G1 box; other site 633147001003 GTP/Mg2+ binding site [chemical binding]; other site 633147001004 G2 box; other site 633147001005 G3 box; other site 633147001006 Switch II region; other site 633147001007 G4 box; other site 633147001008 G5 box; other site 633147001009 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 633147001010 Rubredoxin; Region: Rubredoxin; pfam00301 633147001011 iron binding site [ion binding]; other site 633147001012 rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046 633147001013 Rubrerythrin [Energy production and conversion]; Region: COG1592 633147001014 diiron binding motif [ion binding]; other site 633147001015 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 633147001016 metal binding site 2 [ion binding]; metal-binding site 633147001017 putative DNA binding helix; other site 633147001018 metal binding site 1 [ion binding]; metal-binding site 633147001019 dimer interface [polypeptide binding]; other site 633147001020 structural Zn2+ binding site [ion binding]; other site 633147001021 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 633147001022 nudix motif; other site 633147001023 active site 633147001024 metal binding site [ion binding]; metal-binding site 633147001025 Flavin Reductases; Region: FlaRed; cl00801 633147001026 AAA ATPase domain; Region: AAA_16; pfam13191 633147001027 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 633147001028 FeoA domain; Region: FeoA; pfam04023 633147001029 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 633147001030 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 633147001031 G1 box; other site 633147001032 GTP/Mg2+ binding site [chemical binding]; other site 633147001033 Switch I region; other site 633147001034 G2 box; other site 633147001035 G3 box; other site 633147001036 Switch II region; other site 633147001037 G4 box; other site 633147001038 G5 box; other site 633147001039 Nucleoside recognition; Region: Gate; pfam07670 633147001040 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 633147001041 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 633147001042 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 633147001043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633147001044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633147001045 Coenzyme A binding pocket [chemical binding]; other site 633147001046 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633147001047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147001048 non-specific DNA binding site [nucleotide binding]; other site 633147001049 salt bridge; other site 633147001050 sequence-specific DNA binding site [nucleotide binding]; other site 633147001051 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 633147001052 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 633147001053 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147001054 dimerization interface [polypeptide binding]; other site 633147001055 putative DNA binding site [nucleotide binding]; other site 633147001056 putative Zn2+ binding site [ion binding]; other site 633147001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147001058 S-adenosylmethionine binding site [chemical binding]; other site 633147001059 ThiF family; Region: ThiF; pfam00899 633147001060 ATP binding site [chemical binding]; other site 633147001061 H+ Antiporter protein; Region: 2A0121; TIGR00900 633147001062 LytTr DNA-binding domain; Region: LytTR; pfam04397 633147001063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147001064 phosphorylation site [posttranslational modification] 633147001065 intermolecular recognition site; other site 633147001066 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147001067 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 633147001068 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 633147001069 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 633147001070 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147001071 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147001072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001073 Walker A/P-loop; other site 633147001074 ATP binding site [chemical binding]; other site 633147001075 Q-loop/lid; other site 633147001076 ABC transporter signature motif; other site 633147001077 Walker B; other site 633147001078 D-loop; other site 633147001079 H-loop/switch region; other site 633147001080 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 633147001081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001082 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633147001083 active site 633147001084 motif I; other site 633147001085 motif II; other site 633147001086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001087 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001089 DNA-binding site [nucleotide binding]; DNA binding site 633147001090 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633147001091 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 633147001092 active site 633147001093 catalytic residues [active] 633147001094 metal binding site [ion binding]; metal-binding site 633147001095 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147001096 dimerization interface [polypeptide binding]; other site 633147001097 putative DNA binding site [nucleotide binding]; other site 633147001098 putative Zn2+ binding site [ion binding]; other site 633147001099 Predicted membrane protein [Function unknown]; Region: COG4905 633147001100 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633147001101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147001102 Zn2+ binding site [ion binding]; other site 633147001103 Mg2+ binding site [ion binding]; other site 633147001104 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633147001105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001106 active site 633147001107 motif I; other site 633147001108 motif II; other site 633147001109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001110 isocitrate dehydrogenase; Validated; Region: PRK08299 633147001111 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 633147001112 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 633147001113 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 633147001114 enolase; Provisional; Region: eno; PRK00077 633147001115 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 633147001116 dimer interface [polypeptide binding]; other site 633147001117 metal binding site [ion binding]; metal-binding site 633147001118 substrate binding pocket [chemical binding]; other site 633147001119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147001120 S-adenosylmethionine binding site [chemical binding]; other site 633147001121 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633147001122 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633147001123 putative substrate binding site [chemical binding]; other site 633147001124 putative ATP binding site [chemical binding]; other site 633147001125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147001126 Zn2+ binding site [ion binding]; other site 633147001127 Mg2+ binding site [ion binding]; other site 633147001128 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 633147001129 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 633147001130 DRTGG domain; Region: DRTGG; pfam07085 633147001131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 633147001132 DHH family; Region: DHH; pfam01368 633147001133 DHHA2 domain; Region: DHHA2; pfam02833 633147001134 EamA-like transporter family; Region: EamA; pfam00892 633147001135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147001136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147001137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633147001138 dimerization interface [polypeptide binding]; other site 633147001139 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 633147001140 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 633147001141 putative catalytic cysteine [active] 633147001142 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 633147001143 active site 633147001144 homodimer interface [polypeptide binding]; other site 633147001145 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 633147001146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001147 Walker A/P-loop; other site 633147001148 ATP binding site [chemical binding]; other site 633147001149 Q-loop/lid; other site 633147001150 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147001151 ABC transporter; Region: ABC_tran_2; pfam12848 633147001152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147001153 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633147001154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147001155 active site 633147001156 phosphorylation site [posttranslational modification] 633147001157 intermolecular recognition site; other site 633147001158 dimerization interface [polypeptide binding]; other site 633147001159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147001160 DNA binding residues [nucleotide binding] 633147001161 dimerization interface [polypeptide binding]; other site 633147001162 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 633147001163 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 633147001164 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 633147001165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 633147001166 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 633147001167 ATP binding site [chemical binding]; other site 633147001168 Mg2+ binding site [ion binding]; other site 633147001169 G-X-G motif; other site 633147001170 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 633147001171 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147001172 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633147001173 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 633147001174 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 633147001175 active site 633147001176 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 633147001177 Malic enzyme, N-terminal domain; Region: malic; pfam00390 633147001178 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 633147001179 putative NAD(P) binding site [chemical binding]; other site 633147001180 fumarate hydratase; Reviewed; Region: fumC; PRK00485 633147001181 Class II fumarases; Region: Fumarase_classII; cd01362 633147001182 active site 633147001183 tetramer interface [polypeptide binding]; other site 633147001184 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 633147001185 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633147001186 FMN binding site [chemical binding]; other site 633147001187 dimer interface [polypeptide binding]; other site 633147001188 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633147001189 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 633147001190 B3/4 domain; Region: B3_4; pfam03483 633147001191 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 633147001192 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 633147001193 GAF domain; Region: GAF_2; pfam13185 633147001194 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 633147001195 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 633147001196 putative dimer interface [polypeptide binding]; other site 633147001197 putative anticodon binding site; other site 633147001198 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 633147001199 homodimer interface [polypeptide binding]; other site 633147001200 motif 1; other site 633147001201 motif 2; other site 633147001202 active site 633147001203 motif 3; other site 633147001204 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633147001205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 633147001206 HTH domain; Region: HTH_11; pfam08279 633147001207 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 633147001208 HTH domain; Region: HTH_11; pfam08279 633147001209 PRD domain; Region: PRD; pfam00874 633147001210 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 633147001211 active site 633147001212 P-loop; other site 633147001213 phosphorylation site [posttranslational modification] 633147001214 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147001215 active site 633147001216 phosphorylation site [posttranslational modification] 633147001217 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147001218 active site 633147001219 phosphorylation site [posttranslational modification] 633147001220 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 633147001221 active site 633147001222 P-loop; other site 633147001223 phosphorylation site [posttranslational modification] 633147001224 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633147001225 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633147001226 intersubunit interface [polypeptide binding]; other site 633147001227 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 633147001228 active site 633147001229 Zn2+ binding site [ion binding]; other site 633147001230 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 633147001231 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 633147001232 DAK2 domain; Region: Dak2; pfam02734 633147001233 dihydroxyacetone kinase; Provisional; Region: PRK14479 633147001234 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 633147001235 DAK2 domain; Region: Dak2; pfam02734 633147001236 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001238 DNA-binding site [nucleotide binding]; DNA binding site 633147001239 UTRA domain; Region: UTRA; pfam07702 633147001240 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633147001241 intersubunit interface [polypeptide binding]; other site 633147001242 active site 633147001243 zinc binding site [ion binding]; other site 633147001244 Na+ binding site [ion binding]; other site 633147001245 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 633147001246 active site 633147001247 P-loop; other site 633147001248 phosphorylation site [posttranslational modification] 633147001249 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633147001250 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633147001251 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 633147001252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633147001253 nucleotide binding site [chemical binding]; other site 633147001254 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633147001255 catalytic core [active] 633147001256 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 633147001257 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 633147001258 dimer interface [polypeptide binding]; other site 633147001259 putative active site [active] 633147001260 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 633147001261 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 633147001262 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 633147001263 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147001264 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147001265 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633147001266 HPr interaction site; other site 633147001267 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633147001268 active site 633147001269 phosphorylation site [posttranslational modification] 633147001270 GGGtGRT protein; Region: GGGtGRT; pfam14057 633147001271 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 633147001272 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 633147001273 SWIM zinc finger; Region: SWIM; pfam04434 633147001274 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 633147001275 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 633147001276 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147001277 ATP binding site [chemical binding]; other site 633147001278 putative Mg++ binding site [ion binding]; other site 633147001279 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147001280 nucleotide binding region [chemical binding]; other site 633147001281 ATP-binding site [chemical binding]; other site 633147001282 Predicted acetyltransferase [General function prediction only]; Region: COG2388 633147001283 Protein of unknown function (DUF554); Region: DUF554; pfam04474 633147001284 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147001285 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147001286 substrate binding pocket [chemical binding]; other site 633147001287 membrane-bound complex binding site; other site 633147001288 hinge residues; other site 633147001289 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 633147001290 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 633147001291 DNA binding site [nucleotide binding] 633147001292 active site 633147001293 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 633147001294 intersubunit interface [polypeptide binding]; other site 633147001295 active site 633147001296 catalytic residue [active] 633147001297 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 633147001298 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001300 DNA-binding site [nucleotide binding]; DNA binding site 633147001301 UTRA domain; Region: UTRA; pfam07702 633147001302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147001303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147001304 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 633147001305 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 633147001306 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 633147001307 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 633147001308 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 633147001309 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 633147001310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 633147001311 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 633147001312 peptidase T; Region: peptidase-T; TIGR01882 633147001313 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633147001314 metal binding site [ion binding]; metal-binding site 633147001315 dimer interface [polypeptide binding]; other site 633147001316 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633147001317 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633147001318 active site 633147001319 substrate binding [chemical binding]; other site 633147001320 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 633147001321 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147001322 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 633147001323 putative substrate binding site [chemical binding]; other site 633147001324 putative ATP binding site [chemical binding]; other site 633147001325 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 633147001326 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633147001327 active site turn [active] 633147001328 phosphorylation site [posttranslational modification] 633147001329 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633147001330 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633147001331 HPr interaction site; other site 633147001332 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633147001333 active site 633147001334 phosphorylation site [posttranslational modification] 633147001335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633147001336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633147001337 DNA binding site [nucleotide binding] 633147001338 domain linker motif; other site 633147001339 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 633147001340 dimerization interface [polypeptide binding]; other site 633147001341 ligand binding site [chemical binding]; other site 633147001342 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633147001343 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633147001344 substrate binding [chemical binding]; other site 633147001345 active site 633147001346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 633147001347 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633147001348 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 633147001349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 633147001350 ORF6N domain; Region: ORF6N; pfam10543 633147001351 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 633147001352 Predicted transcriptional regulator [Transcription]; Region: COG5340 633147001353 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633147001354 ORF6N domain; Region: ORF6N; pfam10543 633147001355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001356 AAA domain; Region: AAA_21; pfam13304 633147001357 Walker A/P-loop; other site 633147001358 ATP binding site [chemical binding]; other site 633147001359 RloB-like protein; Region: RloB; pfam13707 633147001360 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 633147001361 GIY-YIG motif/motif A; other site 633147001362 active site 633147001363 catalytic site [active] 633147001364 metal binding site [ion binding]; metal-binding site 633147001365 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 633147001366 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 633147001367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001369 DNA-binding site [nucleotide binding]; DNA binding site 633147001370 UTRA domain; Region: UTRA; pfam07702 633147001371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001372 DNA-binding site [nucleotide binding]; DNA binding site 633147001373 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001374 UTRA domain; Region: UTRA; pfam07702 633147001375 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 633147001376 dimer interface [polypeptide binding]; other site 633147001377 active site 633147001378 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147001379 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147001380 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147001381 fructoselysine 3-epimerase; Provisional; Region: PRK09856 633147001382 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 633147001383 Metal-binding active site; metal-binding site 633147001384 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633147001385 active pocket/dimerization site; other site 633147001386 active site 633147001387 phosphorylation site [posttranslational modification] 633147001388 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633147001389 active site 633147001390 phosphorylation site [posttranslational modification] 633147001391 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633147001392 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633147001393 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 633147001394 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633147001395 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 633147001396 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 633147001397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 633147001398 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147001399 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633147001400 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147001401 Walker A/P-loop; other site 633147001402 ATP binding site [chemical binding]; other site 633147001403 Q-loop/lid; other site 633147001404 ABC transporter signature motif; other site 633147001405 Walker B; other site 633147001406 D-loop; other site 633147001407 H-loop/switch region; other site 633147001408 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001409 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 633147001410 Walker A/P-loop; other site 633147001411 ATP binding site [chemical binding]; other site 633147001412 Q-loop/lid; other site 633147001413 ABC transporter signature motif; other site 633147001414 Walker B; other site 633147001415 D-loop; other site 633147001416 H-loop/switch region; other site 633147001417 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 633147001418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147001419 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147001420 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001421 Walker A/P-loop; other site 633147001422 ATP binding site [chemical binding]; other site 633147001423 Q-loop/lid; other site 633147001424 ABC transporter signature motif; other site 633147001425 Walker B; other site 633147001426 D-loop; other site 633147001427 H-loop/switch region; other site 633147001428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147001429 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147001430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001431 Walker A/P-loop; other site 633147001432 ATP binding site [chemical binding]; other site 633147001433 Q-loop/lid; other site 633147001434 ABC transporter signature motif; other site 633147001435 Walker B; other site 633147001436 D-loop; other site 633147001437 H-loop/switch region; other site 633147001438 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 633147001439 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 633147001440 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 633147001441 putative active site [active] 633147001442 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633147001443 active site turn [active] 633147001444 phosphorylation site [posttranslational modification] 633147001445 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 633147001446 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 633147001447 active site 633147001448 FMN binding site [chemical binding]; other site 633147001449 substrate binding site [chemical binding]; other site 633147001450 putative catalytic residue [active] 633147001451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633147001452 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 633147001453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633147001454 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633147001455 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 633147001456 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147001457 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633147001458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001459 motif II; other site 633147001460 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633147001461 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 633147001462 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 633147001463 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 633147001464 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 633147001465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 633147001466 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 633147001467 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 633147001468 active site 633147001469 ADP/pyrophosphate binding site [chemical binding]; other site 633147001470 dimerization interface [polypeptide binding]; other site 633147001471 allosteric effector site; other site 633147001472 fructose-1,6-bisphosphate binding site; other site 633147001473 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 633147001474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001475 Walker A/P-loop; other site 633147001476 ATP binding site [chemical binding]; other site 633147001477 Q-loop/lid; other site 633147001478 ABC transporter signature motif; other site 633147001479 Walker B; other site 633147001480 D-loop; other site 633147001481 H-loop/switch region; other site 633147001482 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147001483 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 633147001484 TM-ABC transporter signature motif; other site 633147001485 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 633147001486 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 633147001487 zinc binding site [ion binding]; other site 633147001488 putative ligand binding site [chemical binding]; other site 633147001489 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 633147001490 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 633147001491 dimer interface [polypeptide binding]; other site 633147001492 active site 633147001493 metal binding site [ion binding]; metal-binding site 633147001494 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 633147001495 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 633147001496 dimer interface [polypeptide binding]; other site 633147001497 PYR/PP interface [polypeptide binding]; other site 633147001498 TPP binding site [chemical binding]; other site 633147001499 substrate binding site [chemical binding]; other site 633147001500 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 633147001501 Domain of unknown function; Region: EKR; pfam10371 633147001502 4Fe-4S binding domain; Region: Fer4_6; pfam12837 633147001503 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 633147001504 TPP-binding site [chemical binding]; other site 633147001505 dimer interface [polypeptide binding]; other site 633147001506 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 633147001507 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 633147001508 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 633147001509 Part of AAA domain; Region: AAA_19; pfam13245 633147001510 Family description; Region: UvrD_C_2; pfam13538 633147001511 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 633147001512 G1 box; other site 633147001513 GTP/Mg2+ binding site [chemical binding]; other site 633147001514 Switch I region; other site 633147001515 G2 box; other site 633147001516 G3 box; other site 633147001517 Switch II region; other site 633147001518 G4 box; other site 633147001519 G5 box; other site 633147001520 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147001521 ATP binding site [chemical binding]; other site 633147001522 putative Mg++ binding site [ion binding]; other site 633147001523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147001524 nucleotide binding region [chemical binding]; other site 633147001525 ATP-binding site [chemical binding]; other site 633147001526 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 633147001527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147001528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147001529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 633147001530 dimerization interface [polypeptide binding]; other site 633147001531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147001532 non-specific DNA binding site [nucleotide binding]; other site 633147001533 salt bridge; other site 633147001534 sequence-specific DNA binding site [nucleotide binding]; other site 633147001535 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 633147001536 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 633147001537 catalytic triad [active] 633147001538 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 633147001539 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 633147001540 acyl-activating enzyme (AAE) consensus motif; other site 633147001541 AMP binding site [chemical binding]; other site 633147001542 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 633147001543 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 633147001544 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633147001545 catalytic residue [active] 633147001546 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 633147001547 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 633147001548 homodimer interface [polypeptide binding]; other site 633147001549 substrate-cofactor binding pocket; other site 633147001550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147001551 catalytic residue [active] 633147001552 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 633147001553 GIY-YIG motif/motif A; other site 633147001554 putative active site [active] 633147001555 putative metal binding site [ion binding]; other site 633147001556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 633147001557 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 633147001558 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147001559 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147001560 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147001561 glycerol kinase; Provisional; Region: glpK; PRK00047 633147001562 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 633147001563 N- and C-terminal domain interface [polypeptide binding]; other site 633147001564 active site 633147001565 MgATP binding site [chemical binding]; other site 633147001566 catalytic site [active] 633147001567 metal binding site [ion binding]; metal-binding site 633147001568 glycerol binding site [chemical binding]; other site 633147001569 homotetramer interface [polypeptide binding]; other site 633147001570 homodimer interface [polypeptide binding]; other site 633147001571 FBP binding site [chemical binding]; other site 633147001572 protein IIAGlc interface [polypeptide binding]; other site 633147001573 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 633147001574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 633147001575 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633147001576 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 633147001577 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 633147001578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147001579 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 633147001580 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 633147001581 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 633147001582 active site 633147001583 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 633147001584 DUF35 OB-fold domain; Region: DUF35; pfam01796 633147001585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 633147001586 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 633147001587 butyrate kinase; Provisional; Region: PRK03011 633147001588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147001589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147001590 putative substrate translocation pore; other site 633147001591 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 633147001592 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 633147001593 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 633147001594 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 633147001595 putative active site [active] 633147001596 dimerization interface [polypeptide binding]; other site 633147001597 putative tRNAtyr binding site [nucleotide binding]; other site 633147001598 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 633147001599 active site 633147001600 Zn binding site [ion binding]; other site 633147001601 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633147001602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633147001603 nucleotide binding site [chemical binding]; other site 633147001604 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633147001605 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 633147001606 active site 633147001607 P-loop; other site 633147001608 phosphorylation site [posttranslational modification] 633147001609 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 633147001610 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147001611 active site 633147001612 phosphorylation site [posttranslational modification] 633147001613 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633147001614 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633147001615 putative substrate binding site [chemical binding]; other site 633147001616 putative ATP binding site [chemical binding]; other site 633147001617 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633147001618 intersubunit interface [polypeptide binding]; other site 633147001619 active site 633147001620 zinc binding site [ion binding]; other site 633147001621 Na+ binding site [ion binding]; other site 633147001622 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633147001623 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 633147001624 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633147001625 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 633147001626 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 633147001627 active site 633147001628 dimer interface [polypeptide binding]; other site 633147001629 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633147001630 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 633147001631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 633147001632 metal binding site [ion binding]; metal-binding site 633147001633 active site 633147001634 I-site; other site 633147001635 Collagen binding domain; Region: Collagen_bind; pfam05737 633147001636 Cna protein B-type domain; Region: Cna_B; pfam05738 633147001637 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147001638 domain interaction interfaces [polypeptide binding]; other site 633147001639 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147001640 domain interaction interfaces [polypeptide binding]; other site 633147001641 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147001642 domain interaction interfaces [polypeptide binding]; other site 633147001643 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147001644 domain interaction interfaces [polypeptide binding]; other site 633147001645 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 633147001646 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 633147001647 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 633147001648 dimer interface [polypeptide binding]; other site 633147001649 motif 1; other site 633147001650 active site 633147001651 motif 2; other site 633147001652 motif 3; other site 633147001653 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 633147001654 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 633147001655 putative tRNA-binding site [nucleotide binding]; other site 633147001656 B3/4 domain; Region: B3_4; pfam03483 633147001657 tRNA synthetase B5 domain; Region: B5; smart00874 633147001658 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 633147001659 dimer interface [polypeptide binding]; other site 633147001660 motif 1; other site 633147001661 motif 3; other site 633147001662 motif 2; other site 633147001663 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 633147001664 mitochondrial import inner membrane, translocase subunit; Region: 3a0801s03tim44; TIGR00984 633147001665 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001667 DNA-binding site [nucleotide binding]; DNA binding site 633147001668 UTRA domain; Region: UTRA; pfam07702 633147001669 Alpha amylase catalytic domain found in eukaryotic and bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_euk_bac_CMD_like; cd11353 633147001670 active site 633147001671 catalytic site [active] 633147001672 pyruvate kinase; Provisional; Region: PRK05826 633147001673 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 633147001674 domain interfaces; other site 633147001675 active site 633147001676 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 633147001677 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 633147001678 putative ligand binding site [chemical binding]; other site 633147001679 putative NAD binding site [chemical binding]; other site 633147001680 catalytic site [active] 633147001681 ribosome small subunit-dependent GTPase A; Region: TIGR00157 633147001682 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 633147001683 GTPase/Zn-binding domain interface [polypeptide binding]; other site 633147001684 GTP/Mg2+ binding site [chemical binding]; other site 633147001685 G4 box; other site 633147001686 G5 box; other site 633147001687 G1 box; other site 633147001688 Switch I region; other site 633147001689 G2 box; other site 633147001690 G3 box; other site 633147001691 Switch II region; other site 633147001692 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 633147001693 AAA domain; Region: AAA_31; pfam13614 633147001694 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 633147001695 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 633147001696 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 633147001697 ATP binding site [chemical binding]; other site 633147001698 Walker A motif; other site 633147001699 hexamer interface [polypeptide binding]; other site 633147001700 Walker B motif; other site 633147001701 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 633147001702 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 633147001703 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 633147001704 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 633147001705 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147001706 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147001707 phosphopeptide binding site; other site 633147001708 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 633147001709 Ferritin-like domain; Region: Ferritin; pfam00210 633147001710 ferroxidase diiron center [ion binding]; other site 633147001711 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 633147001712 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633147001713 Acylphosphatase; Region: Acylphosphatase; pfam00708 633147001714 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147001715 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147001716 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 633147001717 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 633147001718 citrate synthase; Provisional; Region: PRK14032 633147001719 Citrate synthase; Region: Citrate_synt; pfam00285 633147001720 oxalacetate binding site [chemical binding]; other site 633147001721 citrylCoA binding site [chemical binding]; other site 633147001722 coenzyme A binding site [chemical binding]; other site 633147001723 catalytic triad [active] 633147001724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001725 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633147001726 active site 633147001727 motif I; other site 633147001728 motif II; other site 633147001729 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633147001730 K+ potassium transporter; Region: K_trans; pfam02705 633147001731 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 633147001732 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 633147001733 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 633147001734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147001735 S-adenosylmethionine binding site [chemical binding]; other site 633147001736 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 633147001737 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 633147001738 active site 633147001739 substrate binding site [chemical binding]; other site 633147001740 metal binding site [ion binding]; metal-binding site 633147001741 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 633147001742 putative active site [active] 633147001743 Arginine repressor [Transcription]; Region: ArgR; COG1438 633147001744 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 633147001745 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 633147001746 Transglycosylase; Region: Transgly; pfam00912 633147001747 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 633147001748 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 633147001749 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 633147001750 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 633147001751 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147001752 active site 633147001753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 633147001754 LicD family; Region: LicD; pfam04991 633147001755 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 633147001756 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 633147001757 Acyltransferase family; Region: Acyl_transf_3; pfam01757 633147001758 putative glycosyl transferase; Provisional; Region: PRK10073 633147001759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147001760 active site 633147001761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147001762 active site 633147001763 LicD family; Region: LicD; cl01378 633147001764 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 633147001765 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 633147001766 PYR/PP interface [polypeptide binding]; other site 633147001767 dimer interface [polypeptide binding]; other site 633147001768 TPP binding site [chemical binding]; other site 633147001769 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 633147001770 TPP-binding site; other site 633147001771 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 633147001772 active site 633147001773 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 633147001774 metal-binding site 633147001775 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147001776 active site 633147001777 nucleotide binding site [chemical binding]; other site 633147001778 HIGH motif; other site 633147001779 KMSKS motif; other site 633147001780 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 633147001781 tetramer interface [polypeptide binding]; other site 633147001782 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 633147001783 active site 633147001784 Mg2+/Mn2+ binding site [ion binding]; other site 633147001785 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147001786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147001787 catalytic residue [active] 633147001788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 633147001789 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 633147001790 Ligand binding site; other site 633147001791 Putative Catalytic site; other site 633147001792 DXD motif; other site 633147001793 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 633147001794 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 633147001795 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 633147001796 substrate binding site; other site 633147001797 tetramer interface; other site 633147001798 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 633147001799 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 633147001800 NAD binding site [chemical binding]; other site 633147001801 substrate binding site [chemical binding]; other site 633147001802 homodimer interface [polypeptide binding]; other site 633147001803 active site 633147001804 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 633147001805 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 633147001806 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 633147001807 NADP binding site [chemical binding]; other site 633147001808 active site 633147001809 putative substrate binding site [chemical binding]; other site 633147001810 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 633147001811 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 633147001812 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 633147001813 active site 633147001814 metal-binding site 633147001815 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 633147001816 active site 633147001817 substrate binding site [chemical binding]; other site 633147001818 ATP binding site [chemical binding]; other site 633147001819 Phosphotransferase enzyme family; Region: APH; pfam01636 633147001820 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 633147001821 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 633147001822 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 633147001823 active site 633147001824 metal binding site [ion binding]; metal-binding site 633147001825 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 633147001826 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 633147001827 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 633147001828 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 633147001829 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 633147001830 active site 633147001831 HIGH motif; other site 633147001832 dimer interface [polypeptide binding]; other site 633147001833 KMSKS motif; other site 633147001834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 633147001835 RNA binding surface [nucleotide binding]; other site 633147001836 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 633147001837 Peptidase family U32; Region: Peptidase_U32; pfam01136 633147001838 Collagenase; Region: DUF3656; pfam12392 633147001839 Peptidase family U32; Region: Peptidase_U32; cl03113 633147001840 NifU-like domain; Region: NifU; cl00484 633147001841 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 633147001842 LicD family; Region: LicD; pfam04991 633147001843 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147001844 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 633147001845 active site 633147001846 nucleotide binding site [chemical binding]; other site 633147001847 HIGH motif; other site 633147001848 KMSKS motif; other site 633147001849 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 633147001850 active site 633147001851 oxyanion hole [active] 633147001852 catalytic triad [active] 633147001853 hypothetical protein; Validated; Region: PRK00110 633147001854 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633147001855 HSP70 interaction site [polypeptide binding]; other site 633147001856 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 633147001857 Asp23 family; Region: Asp23; pfam03780 633147001858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633147001859 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 633147001860 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 633147001861 catalytic triad [active] 633147001862 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147001863 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 633147001864 substrate binding site [chemical binding]; other site 633147001865 dimer interface [polypeptide binding]; other site 633147001866 ATP binding site [chemical binding]; other site 633147001867 Acyltransferase family; Region: Acyl_transf_3; pfam01757 633147001868 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 633147001869 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147001870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147001871 DNA-binding site [nucleotide binding]; DNA binding site 633147001872 UTRA domain; Region: UTRA; pfam07702 633147001873 Predicted membrane protein [Function unknown]; Region: COG1288 633147001874 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 633147001875 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 633147001876 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633147001877 active site 633147001878 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 633147001879 putative active site [active] 633147001880 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147001881 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 633147001882 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147001883 substrate binding site [chemical binding]; other site 633147001884 ATP binding site [chemical binding]; other site 633147001885 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147001886 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147001887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001888 Walker A/P-loop; other site 633147001889 ATP binding site [chemical binding]; other site 633147001890 Q-loop/lid; other site 633147001891 ABC transporter signature motif; other site 633147001892 Walker B; other site 633147001893 D-loop; other site 633147001894 H-loop/switch region; other site 633147001895 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633147001896 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147001897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001898 Walker A/P-loop; other site 633147001899 ATP binding site [chemical binding]; other site 633147001900 Q-loop/lid; other site 633147001901 ABC transporter signature motif; other site 633147001902 Walker B; other site 633147001903 D-loop; other site 633147001904 H-loop/switch region; other site 633147001905 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633147001906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147001907 active site 633147001908 phosphorylation site [posttranslational modification] 633147001909 intermolecular recognition site; other site 633147001910 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147001911 DNA binding residues [nucleotide binding] 633147001912 dimerization interface [polypeptide binding]; other site 633147001913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 633147001914 Histidine kinase; Region: HisKA_3; pfam07730 633147001915 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 633147001916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 633147001917 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 633147001918 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 633147001919 Walker A/P-loop; other site 633147001920 ATP binding site [chemical binding]; other site 633147001921 Q-loop/lid; other site 633147001922 ABC transporter signature motif; other site 633147001923 Walker B; other site 633147001924 D-loop; other site 633147001925 H-loop/switch region; other site 633147001926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147001927 dimer interface [polypeptide binding]; other site 633147001928 conserved gate region; other site 633147001929 putative PBP binding loops; other site 633147001930 ABC-ATPase subunit interface; other site 633147001931 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 633147001932 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633147001933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147001934 Walker A/P-loop; other site 633147001935 ATP binding site [chemical binding]; other site 633147001936 Q-loop/lid; other site 633147001937 ABC transporter signature motif; other site 633147001938 Walker B; other site 633147001939 D-loop; other site 633147001940 H-loop/switch region; other site 633147001941 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 633147001942 active site residue [active] 633147001943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001944 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633147001945 active site 633147001946 motif I; other site 633147001947 motif II; other site 633147001948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147001949 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 633147001950 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 633147001951 dimer interface [polypeptide binding]; other site 633147001952 active site 633147001953 metal binding site [ion binding]; metal-binding site 633147001954 LytTr DNA-binding domain; Region: LytTR; pfam04397 633147001955 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 633147001956 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633147001957 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 633147001958 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 633147001959 active site 633147001960 phosphorylation site [posttranslational modification] 633147001961 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633147001962 active pocket/dimerization site; other site 633147001963 active site 633147001964 phosphorylation site [posttranslational modification] 633147001965 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 633147001966 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633147001967 HPr interaction site; other site 633147001968 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633147001969 active site 633147001970 phosphorylation site [posttranslational modification] 633147001971 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 633147001972 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 633147001973 hypothetical protein; Provisional; Region: PRK03881 633147001974 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 633147001975 AMMECR1; Region: AMMECR1; cl00911 633147001976 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 633147001977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147001978 FeS/SAM binding site; other site 633147001979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147001980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147001981 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 633147001982 hydrophobic ligand binding site; other site 633147001983 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 633147001984 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 633147001985 peroxiredoxin; Region: AhpC; TIGR03137 633147001986 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 633147001987 dimer interface [polypeptide binding]; other site 633147001988 decamer (pentamer of dimers) interface [polypeptide binding]; other site 633147001989 catalytic triad [active] 633147001990 peroxidatic and resolving cysteines [active] 633147001991 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 633147001992 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 633147001993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147001994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147001995 Predicted membrane protein [Function unknown]; Region: COG2323 633147001996 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 633147001997 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633147001998 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 633147001999 active site 633147002000 motif I; other site 633147002001 motif II; other site 633147002002 Eukaryotic phosphomannomutase; Region: PMM; cl17107 633147002003 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633147002004 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633147002005 substrate binding [chemical binding]; other site 633147002006 active site 633147002007 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633147002008 active pocket/dimerization site; other site 633147002009 active site 633147002010 phosphorylation site [posttranslational modification] 633147002011 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633147002012 active site 633147002013 phosphorylation site [posttranslational modification] 633147002014 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633147002015 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633147002016 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 633147002017 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 633147002018 NAD(P) binding site [chemical binding]; other site 633147002019 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 633147002020 active site 633147002021 intersubunit interface [polypeptide binding]; other site 633147002022 zinc binding site [ion binding]; other site 633147002023 Na+ binding site [ion binding]; other site 633147002024 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 633147002025 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633147002026 active site 633147002027 NAD binding site [chemical binding]; other site 633147002028 metal binding site [ion binding]; metal-binding site 633147002029 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 633147002030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 633147002031 DNA binding residues [nucleotide binding] 633147002032 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 633147002033 AAA domain; Region: AAA_22; pfam13401 633147002034 AAA domain; Region: AAA_14; pfam13173 633147002035 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 633147002036 Domain of unknown function DUF77; Region: DUF77; pfam01910 633147002037 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 633147002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147002039 dimer interface [polypeptide binding]; other site 633147002040 conserved gate region; other site 633147002041 putative PBP binding loops; other site 633147002042 ABC-ATPase subunit interface; other site 633147002043 NMT1/THI5 like; Region: NMT1; pfam09084 633147002044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 633147002045 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 633147002046 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 633147002047 Walker A/P-loop; other site 633147002048 ATP binding site [chemical binding]; other site 633147002049 Q-loop/lid; other site 633147002050 ABC transporter signature motif; other site 633147002051 Walker B; other site 633147002052 D-loop; other site 633147002053 H-loop/switch region; other site 633147002054 Sulfatase; Region: Sulfatase; pfam00884 633147002055 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 633147002056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 633147002057 intersubunit interface [polypeptide binding]; other site 633147002058 active site 633147002059 zinc binding site [ion binding]; other site 633147002060 Na+ binding site [ion binding]; other site 633147002061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 633147002062 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 633147002063 ligand binding site [chemical binding]; other site 633147002064 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 633147002065 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 633147002066 beta-galactosidase; Region: BGL; TIGR03356 633147002067 Transcriptional regulator; Region: Rrf2; cl17282 633147002068 Rrf2 family protein; Region: rrf2_super; TIGR00738 633147002069 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 633147002070 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 633147002071 trimerization site [polypeptide binding]; other site 633147002072 active site 633147002073 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 633147002074 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 633147002075 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147002076 catalytic residue [active] 633147002077 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 633147002078 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 633147002079 FeS assembly protein SufB; Region: sufB; TIGR01980 633147002080 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 633147002081 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 633147002082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002083 Walker A/P-loop; other site 633147002084 ATP binding site [chemical binding]; other site 633147002085 Q-loop/lid; other site 633147002086 ABC transporter signature motif; other site 633147002087 Walker B; other site 633147002088 D-loop; other site 633147002089 H-loop/switch region; other site 633147002090 H+ Antiporter protein; Region: 2A0121; TIGR00900 633147002091 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 633147002092 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 633147002093 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 633147002094 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 633147002095 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 633147002096 GatB domain; Region: GatB_Yqey; smart00845 633147002097 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 633147002098 ArsC family; Region: ArsC; pfam03960 633147002099 putative ArsC-like catalytic residues; other site 633147002100 putative TRX-like catalytic residues [active] 633147002101 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 633147002102 nucleophilic elbow; other site 633147002103 catalytic triad; other site 633147002104 Membrane protein of unknown function; Region: DUF360; pfam04020 633147002105 Trp repressor protein; Region: Trp_repressor; cl17266 633147002106 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633147002107 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633147002108 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 633147002109 Family description; Region: UvrD_C_2; pfam13538 633147002110 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 633147002111 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 633147002112 active site 633147002113 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 633147002114 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 633147002115 active site 633147002116 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 633147002117 generic binding surface I; other site 633147002118 generic binding surface II; other site 633147002119 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 633147002120 active site 633147002121 catalytic triad [active] 633147002122 dimer interface [polypeptide binding]; other site 633147002123 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 633147002124 active site 633147002125 putative DNA-binding cleft [nucleotide binding]; other site 633147002126 dimer interface [polypeptide binding]; other site 633147002127 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 633147002128 RuvA N terminal domain; Region: RuvA_N; pfam01330 633147002129 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 633147002130 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 633147002131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147002132 Walker A motif; other site 633147002133 ATP binding site [chemical binding]; other site 633147002134 Walker B motif; other site 633147002135 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 633147002136 Cna protein B-type domain; Region: Cna_B; pfam05738 633147002137 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147002138 domain interaction interfaces [polypeptide binding]; other site 633147002139 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147002140 domain interaction interfaces [polypeptide binding]; other site 633147002141 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147002142 domain interaction interfaces [polypeptide binding]; other site 633147002143 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147002144 domain interaction interfaces [polypeptide binding]; other site 633147002145 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 633147002146 DNA-binding site [nucleotide binding]; DNA binding site 633147002147 RNA-binding motif; other site 633147002148 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 633147002149 dipeptidase PepV; Reviewed; Region: PRK07318 633147002150 active site 633147002151 metal binding site [ion binding]; metal-binding site 633147002152 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 633147002153 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633147002154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147002155 motif II; other site 633147002156 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 633147002157 dipeptidase PepV; Reviewed; Region: PRK07318 633147002158 active site 633147002159 metal binding site [ion binding]; metal-binding site 633147002160 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 633147002161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147002162 TPR motif; other site 633147002163 binding surface 633147002164 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 633147002165 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 633147002166 NodB motif; other site 633147002167 active site 633147002168 catalytic site [active] 633147002169 metal binding site [ion binding]; metal-binding site 633147002170 Uncharacterized conserved protein [Function unknown]; Region: COG4198 633147002171 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 633147002172 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 633147002173 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 633147002174 putative ligand binding site [chemical binding]; other site 633147002175 putative NAD binding site [chemical binding]; other site 633147002176 putative catalytic site [active] 633147002177 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 633147002178 L-serine binding site [chemical binding]; other site 633147002179 ACT domain interface; other site 633147002180 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 633147002181 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147002182 catalytic residue [active] 633147002183 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633147002184 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 633147002185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147002186 motif II; other site 633147002187 Uncharacterized conserved protein [Function unknown]; Region: COG3937 633147002188 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 633147002189 ABC1 family; Region: ABC1; cl17513 633147002190 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 633147002191 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 633147002192 active site 633147002193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002195 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633147002196 Walker A/P-loop; other site 633147002197 ATP binding site [chemical binding]; other site 633147002198 Q-loop/lid; other site 633147002199 ABC transporter signature motif; other site 633147002200 Walker B; other site 633147002201 D-loop; other site 633147002202 H-loop/switch region; other site 633147002203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002206 Walker A/P-loop; other site 633147002207 ATP binding site [chemical binding]; other site 633147002208 Q-loop/lid; other site 633147002209 ABC transporter signature motif; other site 633147002210 Walker B; other site 633147002211 D-loop; other site 633147002212 H-loop/switch region; other site 633147002213 MarR family; Region: MarR; pfam01047 633147002214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147002215 Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: MetG; COG0143 633147002216 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147002217 active site 633147002218 HIGH motif; other site 633147002219 nucleotide binding site [chemical binding]; other site 633147002220 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147002221 KMSKS motif; other site 633147002222 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 633147002223 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 633147002224 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 633147002225 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 633147002226 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 633147002227 dimerization domain swap beta strand [polypeptide binding]; other site 633147002228 regulatory protein interface [polypeptide binding]; other site 633147002229 active site 633147002230 regulatory phosphorylation site [posttranslational modification]; other site 633147002231 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 633147002232 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 633147002233 potential frameshift: common BLAST hit: gi|256827664|ref|YP_003151623.1| protein-export membrane protein SecF/protein-export membrane 633147002234 protein-export membrane protein SecD; Region: secD; TIGR01129 633147002235 Protein export membrane protein; Region: SecD_SecF; cl14618 633147002236 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 633147002237 Protein export membrane protein; Region: SecD_SecF; pfam02355 633147002238 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 633147002239 DHH family; Region: DHH; pfam01368 633147002240 DHHA1 domain; Region: DHHA1; pfam02272 633147002241 DEAD-like helicases superfamily; Region: DEXDc; smart00487 633147002242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147002243 ATP binding site [chemical binding]; other site 633147002244 putative Mg++ binding site [ion binding]; other site 633147002245 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147002246 nucleotide binding region [chemical binding]; other site 633147002247 ATP-binding site [chemical binding]; other site 633147002248 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 633147002249 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147002250 Zn2+ binding site [ion binding]; other site 633147002251 Mg2+ binding site [ion binding]; other site 633147002252 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633147002253 synthetase active site [active] 633147002254 NTP binding site [chemical binding]; other site 633147002255 metal binding site [ion binding]; metal-binding site 633147002256 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 633147002257 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 633147002258 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 633147002259 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633147002260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147002261 non-specific DNA binding site [nucleotide binding]; other site 633147002262 salt bridge; other site 633147002263 sequence-specific DNA binding site [nucleotide binding]; other site 633147002264 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 633147002265 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 633147002266 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 633147002267 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 633147002268 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 633147002269 23S rRNA binding site [nucleotide binding]; other site 633147002270 L21 binding site [polypeptide binding]; other site 633147002271 L13 binding site [polypeptide binding]; other site 633147002272 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 633147002273 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 633147002274 Mg++ binding site [ion binding]; other site 633147002275 putative catalytic motif [active] 633147002276 substrate binding site [chemical binding]; other site 633147002277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 633147002278 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 633147002279 Coenzyme A binding pocket [chemical binding]; other site 633147002280 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 633147002281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147002282 FeS/SAM binding site; other site 633147002283 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 633147002284 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 633147002285 active site 633147002286 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 633147002287 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 633147002288 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147002289 active site 633147002290 HIGH motif; other site 633147002291 nucleotide binding site [chemical binding]; other site 633147002292 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 633147002293 KMSK motif region; other site 633147002294 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633147002295 tRNA binding surface [nucleotide binding]; other site 633147002296 anticodon binding site; other site 633147002297 MarR family; Region: MarR; pfam01047 633147002298 MarR family; Region: MarR_2; pfam12802 633147002299 transcription termination factor Rho; Provisional; Region: rho; PRK09376 633147002300 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 633147002301 RNA binding site [nucleotide binding]; other site 633147002302 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 633147002303 Walker A motif; other site 633147002304 ATP binding site [chemical binding]; other site 633147002305 Walker B motif; other site 633147002306 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 633147002307 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 633147002308 putative ligand binding site [chemical binding]; other site 633147002309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147002310 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 633147002311 TM-ABC transporter signature motif; other site 633147002312 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 633147002313 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 633147002314 TM-ABC transporter signature motif; other site 633147002315 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 633147002316 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 633147002317 Walker A/P-loop; other site 633147002318 ATP binding site [chemical binding]; other site 633147002319 Q-loop/lid; other site 633147002320 ABC transporter signature motif; other site 633147002321 Walker B; other site 633147002322 D-loop; other site 633147002323 H-loop/switch region; other site 633147002324 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 633147002325 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 633147002326 Walker A/P-loop; other site 633147002327 ATP binding site [chemical binding]; other site 633147002328 Q-loop/lid; other site 633147002329 ABC transporter signature motif; other site 633147002330 Walker B; other site 633147002331 D-loop; other site 633147002332 H-loop/switch region; other site 633147002333 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633147002334 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 633147002335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633147002336 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 633147002337 homoserine kinase; Provisional; Region: PRK01212 633147002338 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 633147002339 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 633147002340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147002341 catalytic residue [active] 633147002342 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 633147002343 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 633147002344 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 633147002345 aspartate kinase; Reviewed; Region: PRK09034 633147002346 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 633147002347 nucleotide binding site [chemical binding]; other site 633147002348 substrate binding site [chemical binding]; other site 633147002349 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 633147002350 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 633147002351 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 633147002352 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 633147002353 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 633147002354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633147002355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633147002356 DNA binding residues [nucleotide binding] 633147002357 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 633147002358 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633147002359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002360 Walker A/P-loop; other site 633147002361 ATP binding site [chemical binding]; other site 633147002362 Q-loop/lid; other site 633147002363 ABC transporter signature motif; other site 633147002364 Walker B; other site 633147002365 D-loop; other site 633147002366 H-loop/switch region; other site 633147002367 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633147002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147002369 dimer interface [polypeptide binding]; other site 633147002370 conserved gate region; other site 633147002371 putative PBP binding loops; other site 633147002372 ABC-ATPase subunit interface; other site 633147002373 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147002374 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147002375 substrate binding pocket [chemical binding]; other site 633147002376 membrane-bound complex binding site; other site 633147002377 hinge residues; other site 633147002378 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 633147002379 active site 633147002380 TQXA domain; Region: TQXA_dom; TIGR03934 633147002381 Cna protein B-type domain; Region: Cna_B; pfam05738 633147002382 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 633147002383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 633147002384 ATP binding site [chemical binding]; other site 633147002385 putative Mg++ binding site [ion binding]; other site 633147002386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147002387 nucleotide binding region [chemical binding]; other site 633147002388 ATP-binding site [chemical binding]; other site 633147002389 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 633147002390 dimer interface [polypeptide binding]; other site 633147002391 ADP-ribose binding site [chemical binding]; other site 633147002392 active site 633147002393 nudix motif; other site 633147002394 metal binding site [ion binding]; metal-binding site 633147002395 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 633147002396 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 633147002397 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 633147002398 MarR family; Region: MarR; pfam01047 633147002399 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633147002400 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 633147002401 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 633147002402 putative substrate binding site [chemical binding]; other site 633147002403 putative ATP binding site [chemical binding]; other site 633147002404 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 633147002405 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 633147002406 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 633147002407 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 633147002408 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 633147002409 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 633147002410 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 633147002411 glutamate dehydrogenase; Provisional; Region: PRK09414 633147002412 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 633147002413 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 633147002414 NAD(P) binding site [chemical binding]; other site 633147002415 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 633147002416 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 633147002417 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 633147002418 catalytic site [active] 633147002419 subunit interface [polypeptide binding]; other site 633147002420 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 633147002421 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633147002422 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633147002423 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 633147002424 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 633147002425 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633147002426 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 633147002427 IMP binding site; other site 633147002428 dimer interface [polypeptide binding]; other site 633147002429 interdomain contacts; other site 633147002430 partial ornithine binding site; other site 633147002431 trigger factor; Region: tig; TIGR00115 633147002432 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633147002433 Clp protease; Region: CLP_protease; pfam00574 633147002434 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 633147002435 oligomer interface [polypeptide binding]; other site 633147002436 active site residues [active] 633147002437 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 633147002438 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 633147002439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147002440 Walker B motif; other site 633147002441 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 633147002442 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633147002443 active site 633147002444 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 633147002445 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 633147002446 putative ATP binding site [chemical binding]; other site 633147002447 putative substrate interface [chemical binding]; other site 633147002448 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 633147002449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147002450 active site 633147002451 HIGH motif; other site 633147002452 nucleotide binding site [chemical binding]; other site 633147002453 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633147002454 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 633147002455 active site 633147002456 KMSKS motif; other site 633147002457 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 633147002458 tRNA binding surface [nucleotide binding]; other site 633147002459 anticodon binding site; other site 633147002460 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 633147002461 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 633147002462 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 633147002463 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 633147002464 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 633147002465 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 633147002466 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 633147002467 Potassium binding sites [ion binding]; other site 633147002468 Cesium cation binding sites [ion binding]; other site 633147002469 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 633147002470 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 633147002471 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 633147002472 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 633147002473 homodimer interface [polypeptide binding]; other site 633147002474 NADP binding site [chemical binding]; other site 633147002475 substrate binding site [chemical binding]; other site 633147002476 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 633147002477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633147002478 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 633147002479 Double zinc ribbon; Region: DZR; pfam12773 633147002480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147002481 S-adenosylmethionine binding site [chemical binding]; other site 633147002482 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 633147002483 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 633147002484 TPP-binding site; other site 633147002485 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 633147002486 PYR/PP interface [polypeptide binding]; other site 633147002487 dimer interface [polypeptide binding]; other site 633147002488 TPP binding site [chemical binding]; other site 633147002489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 633147002490 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 633147002491 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 633147002492 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 633147002493 active site 633147002494 dimer interface [polypeptide binding]; other site 633147002495 motif 1; other site 633147002496 motif 2; other site 633147002497 motif 3; other site 633147002498 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 633147002499 anticodon binding site; other site 633147002500 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147002501 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147002502 catalytic residue [active] 633147002503 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 633147002504 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 633147002505 putative catalytic cysteine [active] 633147002506 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 633147002507 putative active site [active] 633147002508 metal binding site [ion binding]; metal-binding site 633147002509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 633147002510 Phosphotransferase enzyme family; Region: APH; pfam01636 633147002511 active site 633147002512 ATP binding site [chemical binding]; other site 633147002513 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 633147002514 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 633147002515 folate binding site [chemical binding]; other site 633147002516 NADP+ binding site [chemical binding]; other site 633147002517 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 633147002518 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 633147002519 dimerization interface [polypeptide binding]; other site 633147002520 active site 633147002521 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 633147002522 active site 633147002523 8-oxo-dGMP binding site [chemical binding]; other site 633147002524 nudix motif; other site 633147002525 metal binding site [ion binding]; metal-binding site 633147002526 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 633147002527 active site 633147002528 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 633147002529 active site 2 [active] 633147002530 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633147002531 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 633147002532 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 633147002533 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 633147002534 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 633147002535 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 633147002536 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 633147002537 catalytic site [active] 633147002538 putative active site [active] 633147002539 putative substrate binding site [chemical binding]; other site 633147002540 HRDC domain; Region: HRDC; pfam00570 633147002541 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 633147002542 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 633147002543 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 633147002544 generic binding surface I; other site 633147002545 generic binding surface II; other site 633147002546 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 633147002547 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 633147002548 nucleotide binding site/active site [active] 633147002549 HIT family signature motif; other site 633147002550 catalytic residue [active] 633147002551 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 633147002552 propionate/acetate kinase; Provisional; Region: PRK12379 633147002553 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 633147002554 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 633147002555 NADP binding site [chemical binding]; other site 633147002556 Predicted transcriptional regulators [Transcription]; Region: COG1695 633147002557 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 633147002558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633147002559 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 633147002560 active site 633147002561 catalytic residues [active] 633147002562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 633147002563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002564 Walker A/P-loop; other site 633147002565 ATP binding site [chemical binding]; other site 633147002566 ABC transporter; Region: ABC_tran; pfam00005 633147002567 Q-loop/lid; other site 633147002568 ABC transporter signature motif; other site 633147002569 Walker B; other site 633147002570 D-loop; other site 633147002571 H-loop/switch region; other site 633147002572 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 633147002573 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 633147002574 active site 633147002575 substrate-binding site [chemical binding]; other site 633147002576 metal-binding site [ion binding] 633147002577 ATP binding site [chemical binding]; other site 633147002578 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 633147002579 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 633147002580 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633147002581 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633147002582 catalytic loop [active] 633147002583 iron binding site [ion binding]; other site 633147002584 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 633147002585 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 633147002586 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 633147002587 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 633147002588 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 633147002589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633147002590 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 633147002591 UDP-galactopyranose mutase; Region: GLF; pfam03275 633147002592 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 633147002593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147002594 active site 633147002595 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 633147002596 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 633147002597 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 633147002598 Ligand binding site; other site 633147002599 metal-binding site 633147002600 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 633147002601 putative active site pocket [active] 633147002602 cleavage site 633147002603 Maf-like protein; Region: Maf; pfam02545 633147002604 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 633147002605 active site 633147002606 dimer interface [polypeptide binding]; other site 633147002607 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 633147002608 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 633147002609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147002610 S-adenosylmethionine binding site [chemical binding]; other site 633147002611 polyphosphate kinase; Provisional; Region: PRK05443 633147002612 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 633147002613 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 633147002614 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 633147002615 putative active site [active] 633147002616 catalytic site [active] 633147002617 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 633147002618 putative active site [active] 633147002619 catalytic site [active] 633147002620 Amidinotransferase; Region: Amidinotransf; cl12043 633147002621 ornithine carbamoyltransferase; Validated; Region: PRK02102 633147002622 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633147002623 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633147002624 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 633147002625 transaminase; Validated; Region: PRK07324 633147002626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633147002627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147002628 homodimer interface [polypeptide binding]; other site 633147002629 catalytic residue [active] 633147002630 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 633147002631 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 633147002632 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 633147002633 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 633147002634 active site 633147002635 HIGH motif; other site 633147002636 dimer interface [polypeptide binding]; other site 633147002637 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147002638 KMSKS motif; other site 633147002639 Protein of unknown function DUF45; Region: DUF45; pfam01863 633147002640 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 633147002641 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 633147002642 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633147002643 active site turn [active] 633147002644 phosphorylation site [posttranslational modification] 633147002645 Dehydroquinase class II; Region: DHquinase_II; pfam01220 633147002646 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 633147002647 trimer interface [polypeptide binding]; other site 633147002648 active site 633147002649 dimer interface [polypeptide binding]; other site 633147002650 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 633147002651 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 633147002652 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 633147002653 NAD(P) binding site [chemical binding]; other site 633147002654 shikimate binding site; other site 633147002655 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 633147002656 Shikimate kinase; Region: SKI; pfam01202 633147002657 ADP binding site [chemical binding]; other site 633147002658 magnesium binding site [ion binding]; other site 633147002659 putative shikimate binding site; other site 633147002660 Chorismate mutase type II; Region: CM_2; pfam01817 633147002661 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 633147002662 Prephenate dehydratase; Region: PDT; pfam00800 633147002663 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 633147002664 putative L-Phe binding site [chemical binding]; other site 633147002665 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 633147002666 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 633147002667 Tetramer interface [polypeptide binding]; other site 633147002668 active site 633147002669 FMN-binding site [chemical binding]; other site 633147002670 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 633147002671 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 633147002672 hinge; other site 633147002673 active site 633147002674 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 633147002675 active site 633147002676 dimer interface [polypeptide binding]; other site 633147002677 metal binding site [ion binding]; metal-binding site 633147002678 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 633147002679 prephenate dehydrogenase; Validated; Region: PRK08507 633147002680 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 633147002681 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 633147002682 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 633147002683 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147002684 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633147002685 aconitate hydratase; Validated; Region: PRK09277 633147002686 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 633147002687 substrate binding site [chemical binding]; other site 633147002688 ligand binding site [chemical binding]; other site 633147002689 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 633147002690 substrate binding site [chemical binding]; other site 633147002691 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 633147002692 active site 633147002693 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147002694 TPR motif; other site 633147002695 binding surface 633147002696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147002697 binding surface 633147002698 TPR motif; other site 633147002699 TPR repeat; Region: TPR_11; pfam13414 633147002700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147002701 binding surface 633147002702 TPR motif; other site 633147002703 rod shape-determining protein MreB; Provisional; Region: PRK13927 633147002704 MreB and similar proteins; Region: MreB_like; cd10225 633147002705 nucleotide binding site [chemical binding]; other site 633147002706 Mg binding site [ion binding]; other site 633147002707 putative protofilament interaction site [polypeptide binding]; other site 633147002708 RodZ interaction site [polypeptide binding]; other site 633147002709 rod shape-determining protein MreC; Provisional; Region: PRK13922 633147002710 rod shape-determining protein MreC; Region: MreC; pfam04085 633147002711 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 633147002712 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 633147002713 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633147002714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633147002715 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 633147002716 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 633147002717 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 633147002718 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147002719 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 633147002720 Walker A/P-loop; other site 633147002721 ATP binding site [chemical binding]; other site 633147002722 Q-loop/lid; other site 633147002723 ABC transporter signature motif; other site 633147002724 Walker B; other site 633147002725 D-loop; other site 633147002726 H-loop/switch region; other site 633147002727 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147002728 Walker A/P-loop; other site 633147002729 ATP binding site [chemical binding]; other site 633147002730 Q-loop/lid; other site 633147002731 ABC transporter signature motif; other site 633147002732 Walker B; other site 633147002733 D-loop; other site 633147002734 H-loop/switch region; other site 633147002735 GTPase CgtA; Reviewed; Region: obgE; PRK12297 633147002736 GTP1/OBG; Region: GTP1_OBG; pfam01018 633147002737 Obg GTPase; Region: Obg; cd01898 633147002738 G1 box; other site 633147002739 GTP/Mg2+ binding site [chemical binding]; other site 633147002740 Switch I region; other site 633147002741 G2 box; other site 633147002742 G3 box; other site 633147002743 Switch II region; other site 633147002744 G4 box; other site 633147002745 G5 box; other site 633147002746 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 633147002747 gamma-glutamyl kinase; Provisional; Region: PRK05429 633147002748 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 633147002749 nucleotide binding site [chemical binding]; other site 633147002750 homotetrameric interface [polypeptide binding]; other site 633147002751 putative phosphate binding site [ion binding]; other site 633147002752 putative allosteric binding site; other site 633147002753 PUA domain; Region: PUA; pfam01472 633147002754 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 633147002755 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 633147002756 active site 633147002757 (T/H)XGH motif; other site 633147002758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147002759 Zn2+ binding site [ion binding]; other site 633147002760 Mg2+ binding site [ion binding]; other site 633147002761 Oligomerisation domain; Region: Oligomerisation; pfam02410 633147002762 DNA polymerase IV; Validated; Region: PRK02406 633147002763 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 633147002764 DNA binding site [nucleotide binding] 633147002765 active site 633147002766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147002767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147002768 dimer interface [polypeptide binding]; other site 633147002769 phosphorylation site [posttranslational modification] 633147002770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147002771 ATP binding site [chemical binding]; other site 633147002772 Mg2+ binding site [ion binding]; other site 633147002773 G-X-G motif; other site 633147002774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147002775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147002776 active site 633147002777 phosphorylation site [posttranslational modification] 633147002778 intermolecular recognition site; other site 633147002779 dimerization interface [polypeptide binding]; other site 633147002780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147002781 DNA binding site [nucleotide binding] 633147002782 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 633147002783 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 633147002784 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 633147002785 G-X-X-G motif; other site 633147002786 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 633147002787 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 633147002788 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 633147002789 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633147002790 Catalytic site [active] 633147002791 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 633147002792 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 633147002793 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 633147002794 dimer interface [polypeptide binding]; other site 633147002795 motif 1; other site 633147002796 active site 633147002797 motif 2; other site 633147002798 motif 3; other site 633147002799 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 633147002800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633147002801 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 633147002802 pyruvate phosphate dikinase; Provisional; Region: PRK09279 633147002803 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 633147002804 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 633147002805 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 633147002806 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 633147002807 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 633147002808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147002809 Zn2+ binding site [ion binding]; other site 633147002810 Mg2+ binding site [ion binding]; other site 633147002811 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 633147002812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147002813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147002814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002817 Walker A/P-loop; other site 633147002818 ATP binding site [chemical binding]; other site 633147002819 Q-loop/lid; other site 633147002820 ABC transporter signature motif; other site 633147002821 Walker B; other site 633147002822 D-loop; other site 633147002823 H-loop/switch region; other site 633147002824 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002825 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002827 Walker A/P-loop; other site 633147002828 ATP binding site [chemical binding]; other site 633147002829 Q-loop/lid; other site 633147002830 ABC transporter signature motif; other site 633147002831 Walker B; other site 633147002832 D-loop; other site 633147002833 H-loop/switch region; other site 633147002834 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 633147002835 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 633147002836 RNA/DNA hybrid binding site [nucleotide binding]; other site 633147002837 active site 633147002838 hypothetical protein; Reviewed; Region: PRK12497 633147002839 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 633147002840 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 633147002841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147002842 Walker A motif; other site 633147002843 ATP binding site [chemical binding]; other site 633147002844 Walker B motif; other site 633147002845 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 633147002846 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 633147002847 Glucose inhibited division protein A; Region: GIDA; pfam01134 633147002848 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 633147002849 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633147002850 active site 633147002851 DNA binding site [nucleotide binding] 633147002852 Int/Topo IB signature motif; other site 633147002853 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 633147002854 rRNA interaction site [nucleotide binding]; other site 633147002855 S8 interaction site; other site 633147002856 putative laminin-1 binding site; other site 633147002857 elongation factor Ts; Provisional; Region: tsf; PRK09377 633147002858 UBA/TS-N domain; Region: UBA; pfam00627 633147002859 Elongation factor TS; Region: EF_TS; pfam00889 633147002860 Elongation factor TS; Region: EF_TS; pfam00889 633147002861 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 633147002862 putative nucleotide binding site [chemical binding]; other site 633147002863 uridine monophosphate binding site [chemical binding]; other site 633147002864 homohexameric interface [polypeptide binding]; other site 633147002865 ribosome recycling factor; Reviewed; Region: frr; PRK00083 633147002866 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 633147002867 hinge region; other site 633147002868 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 633147002869 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 633147002870 catalytic residue [active] 633147002871 putative FPP diphosphate binding site; other site 633147002872 putative FPP binding hydrophobic cleft; other site 633147002873 dimer interface [polypeptide binding]; other site 633147002874 putative IPP diphosphate binding site; other site 633147002875 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 633147002876 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 633147002877 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 633147002878 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 633147002879 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 633147002880 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 633147002881 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633147002882 active site 633147002883 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633147002884 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 633147002885 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 633147002886 protein binding site [polypeptide binding]; other site 633147002887 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 633147002888 putative substrate binding region [chemical binding]; other site 633147002889 GcpE protein; Region: GcpE; pfam04551 633147002890 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 633147002891 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 633147002892 prolyl-tRNA synthetase; Provisional; Region: PRK09194 633147002893 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 633147002894 dimer interface [polypeptide binding]; other site 633147002895 motif 1; other site 633147002896 active site 633147002897 motif 2; other site 633147002898 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 633147002899 putative deacylase active site [active] 633147002900 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633147002901 active site 633147002902 motif 3; other site 633147002903 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 633147002904 anticodon binding site; other site 633147002905 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 633147002906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633147002907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633147002908 DNA binding residues [nucleotide binding] 633147002909 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 633147002910 active site 633147002911 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633147002912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147002913 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147002914 ABC transporter; Region: ABC_tran_2; pfam12848 633147002915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147002916 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 633147002917 Peptidase family M50; Region: Peptidase_M50; pfam02163 633147002918 active site 633147002919 putative substrate binding region [chemical binding]; other site 633147002920 ScpA/B protein; Region: ScpA_ScpB; cl00598 633147002921 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 633147002922 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 633147002923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633147002924 RNA binding surface [nucleotide binding]; other site 633147002925 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 633147002926 active site 633147002927 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633147002928 catalytic core [active] 633147002929 cytidylate kinase; Region: cmk; TIGR00017 633147002930 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 633147002931 CMP-binding site; other site 633147002932 The sites determining sugar specificity; other site 633147002933 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 633147002934 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 633147002935 putative acyl-acceptor binding pocket; other site 633147002936 LytB protein; Region: LYTB; cl00507 633147002937 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 633147002938 GTP-binding protein Der; Reviewed; Region: PRK00093 633147002939 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 633147002940 G1 box; other site 633147002941 GTP/Mg2+ binding site [chemical binding]; other site 633147002942 Switch I region; other site 633147002943 G2 box; other site 633147002944 Switch II region; other site 633147002945 G3 box; other site 633147002946 G4 box; other site 633147002947 G5 box; other site 633147002948 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 633147002949 G1 box; other site 633147002950 GTP/Mg2+ binding site [chemical binding]; other site 633147002951 Switch I region; other site 633147002952 G2 box; other site 633147002953 G3 box; other site 633147002954 Switch II region; other site 633147002955 G4 box; other site 633147002956 G5 box; other site 633147002957 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 633147002958 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 633147002959 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 633147002960 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 633147002961 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 633147002962 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 633147002963 substrate binding site [chemical binding]; other site 633147002964 hexamer interface [polypeptide binding]; other site 633147002965 metal binding site [ion binding]; metal-binding site 633147002966 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 633147002967 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 633147002968 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147002969 catalytic residue [active] 633147002970 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 633147002971 Putative zinc ribbon domain; Region: DUF164; pfam02591 633147002972 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 633147002973 Flavoprotein; Region: Flavoprotein; pfam02441 633147002974 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 633147002975 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633147002976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147002977 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 633147002978 Heavy-metal resistance; Region: Metal_resist; pfam13801 633147002979 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002980 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147002982 Walker A/P-loop; other site 633147002983 ATP binding site [chemical binding]; other site 633147002984 Q-loop/lid; other site 633147002985 ABC transporter signature motif; other site 633147002986 Walker B; other site 633147002987 D-loop; other site 633147002988 H-loop/switch region; other site 633147002989 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147002990 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147002991 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633147002992 Walker A/P-loop; other site 633147002993 ATP binding site [chemical binding]; other site 633147002994 Q-loop/lid; other site 633147002995 ABC transporter signature motif; other site 633147002996 Walker B; other site 633147002997 D-loop; other site 633147002998 H-loop/switch region; other site 633147002999 hydroxyglutarate oxidase; Provisional; Region: PRK11728 633147003000 Predicted dehydrogenase [General function prediction only]; Region: COG0579 633147003001 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 633147003002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 633147003003 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 633147003004 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633147003005 Protein of unknown function (DUF1667); Region: DUF1667; cl17602 633147003006 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 633147003007 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 633147003008 DNA binding site [nucleotide binding] 633147003009 active site 633147003010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147003011 salt bridge; other site 633147003012 non-specific DNA binding site [nucleotide binding]; other site 633147003013 sequence-specific DNA binding site [nucleotide binding]; other site 633147003014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147003015 S-adenosylmethionine binding site [chemical binding]; other site 633147003016 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 633147003017 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 633147003018 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 633147003019 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 633147003020 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 633147003021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633147003022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147003023 homodimer interface [polypeptide binding]; other site 633147003024 catalytic residue [active] 633147003025 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 633147003026 homotrimer interaction site [polypeptide binding]; other site 633147003027 putative active site [active] 633147003028 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147003029 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147003030 phosphopeptide binding site; other site 633147003031 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 633147003032 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 633147003033 DNA binding residues [nucleotide binding] 633147003034 dimer interface [polypeptide binding]; other site 633147003035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147003036 active site 633147003037 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 633147003038 putative YPXnL-motif binding site; other site 633147003039 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 633147003040 NlpC/P60 family; Region: NLPC_P60; pfam00877 633147003041 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 633147003042 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 633147003043 Cl- selectivity filter; other site 633147003044 Cl- binding residues [ion binding]; other site 633147003045 pore gating glutamate residue; other site 633147003046 dimer interface [polypeptide binding]; other site 633147003047 H+/Cl- coupling transport residue; other site 633147003048 TrkA-C domain; Region: TrkA_C; pfam02080 633147003049 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 633147003050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 633147003051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633147003052 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 633147003053 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 633147003054 trimer interface [polypeptide binding]; other site 633147003055 active site 633147003056 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 633147003057 ATP cone domain; Region: ATP-cone; pfam03477 633147003058 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 633147003059 LexA repressor; Validated; Region: PRK00215 633147003060 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147003061 putative DNA binding site [nucleotide binding]; other site 633147003062 putative Zn2+ binding site [ion binding]; other site 633147003063 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 633147003064 Catalytic site [active] 633147003065 Protein of unknown function (DUF1624); Region: DUF1624; pfam07786 633147003066 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 633147003067 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 633147003068 HflX GTPase family; Region: HflX; cd01878 633147003069 G1 box; other site 633147003070 GTP/Mg2+ binding site [chemical binding]; other site 633147003071 Switch I region; other site 633147003072 G2 box; other site 633147003073 G3 box; other site 633147003074 Switch II region; other site 633147003075 G4 box; other site 633147003076 G5 box; other site 633147003077 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 633147003078 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 633147003079 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 633147003080 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 633147003081 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147003082 FeS/SAM binding site; other site 633147003083 TRAM domain; Region: TRAM; pfam01938 633147003084 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 633147003085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147003086 ATP binding site [chemical binding]; other site 633147003087 Mg2+ binding site [ion binding]; other site 633147003088 G-X-G motif; other site 633147003089 phosphodiesterase; Provisional; Region: PRK12704 633147003090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147003091 Zn2+ binding site [ion binding]; other site 633147003092 Mg2+ binding site [ion binding]; other site 633147003093 recombination regulator RecX; Reviewed; Region: recX; PRK00117 633147003094 recombinase A; Provisional; Region: recA; PRK09354 633147003095 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 633147003096 hexamer interface [polypeptide binding]; other site 633147003097 Walker A motif; other site 633147003098 ATP binding site [chemical binding]; other site 633147003099 Walker B motif; other site 633147003100 Competence-damaged protein; Region: CinA; pfam02464 633147003101 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 633147003102 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 633147003103 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 633147003104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147003105 FeS/SAM binding site; other site 633147003106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 633147003107 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 633147003108 Helix-turn-helix domain; Region: HTH_25; pfam13413 633147003109 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 633147003110 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 633147003111 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 633147003112 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 633147003113 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633147003114 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 633147003115 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 633147003116 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 633147003117 RNase E interface [polypeptide binding]; other site 633147003118 trimer interface [polypeptide binding]; other site 633147003119 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 633147003120 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 633147003121 RNase E interface [polypeptide binding]; other site 633147003122 trimer interface [polypeptide binding]; other site 633147003123 active site 633147003124 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 633147003125 putative nucleic acid binding region [nucleotide binding]; other site 633147003126 G-X-X-G motif; other site 633147003127 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 633147003128 RNA binding site [nucleotide binding]; other site 633147003129 domain interface; other site 633147003130 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 633147003131 16S/18S rRNA binding site [nucleotide binding]; other site 633147003132 S13e-L30e interaction site [polypeptide binding]; other site 633147003133 25S rRNA binding site [nucleotide binding]; other site 633147003134 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 633147003135 Recombination protein O N terminal; Region: RecO_N; pfam11967 633147003136 Recombination protein O C terminal; Region: RecO_C; pfam02565 633147003137 GTPase Era; Reviewed; Region: era; PRK00089 633147003138 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 633147003139 G1 box; other site 633147003140 GTP/Mg2+ binding site [chemical binding]; other site 633147003141 Switch I region; other site 633147003142 G2 box; other site 633147003143 Switch II region; other site 633147003144 G3 box; other site 633147003145 G4 box; other site 633147003146 G5 box; other site 633147003147 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 633147003148 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 633147003149 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 633147003150 PhoH-like protein; Region: PhoH; pfam02562 633147003151 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 633147003152 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 633147003153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147003154 FeS/SAM binding site; other site 633147003155 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 633147003156 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633147003157 HSP70 interaction site [polypeptide binding]; other site 633147003158 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633147003159 Zn binding sites [ion binding]; other site 633147003160 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 633147003161 dimer interface [polypeptide binding]; other site 633147003162 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 633147003163 HSP70 interaction site [polypeptide binding]; other site 633147003164 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 633147003165 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 633147003166 Zn binding sites [ion binding]; other site 633147003167 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 633147003168 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 633147003169 HemN C-terminal domain; Region: HemN_C; pfam06969 633147003170 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 633147003171 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 633147003172 FMN binding site [chemical binding]; other site 633147003173 active site 633147003174 catalytic residues [active] 633147003175 substrate binding site [chemical binding]; other site 633147003176 GTP-binding protein LepA; Provisional; Region: PRK05433 633147003177 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 633147003178 G1 box; other site 633147003179 putative GEF interaction site [polypeptide binding]; other site 633147003180 GTP/Mg2+ binding site [chemical binding]; other site 633147003181 Switch I region; other site 633147003182 G2 box; other site 633147003183 G3 box; other site 633147003184 Switch II region; other site 633147003185 G4 box; other site 633147003186 G5 box; other site 633147003187 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 633147003188 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 633147003189 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 633147003190 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 633147003191 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 633147003192 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 633147003193 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 633147003194 Competence protein; Region: Competence; pfam03772 633147003195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633147003196 SLBB domain; Region: SLBB; pfam10531 633147003197 comEA protein; Region: comE; TIGR01259 633147003198 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 633147003199 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 633147003200 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 633147003201 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 633147003202 Ligand Binding Site [chemical binding]; other site 633147003203 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 633147003204 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 633147003205 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 633147003206 catalytic site [active] 633147003207 G-X2-G-X-G-K; other site 633147003208 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 633147003209 active site 633147003210 dimer interface [polypeptide binding]; other site 633147003211 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 633147003212 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 633147003213 heterodimer interface [polypeptide binding]; other site 633147003214 active site 633147003215 FMN binding site [chemical binding]; other site 633147003216 homodimer interface [polypeptide binding]; other site 633147003217 substrate binding site [chemical binding]; other site 633147003218 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 633147003219 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 633147003220 FAD binding pocket [chemical binding]; other site 633147003221 FAD binding motif [chemical binding]; other site 633147003222 phosphate binding motif [ion binding]; other site 633147003223 beta-alpha-beta structure motif; other site 633147003224 NAD binding pocket [chemical binding]; other site 633147003225 Iron coordination center [ion binding]; other site 633147003226 dihydroorotase; Validated; Region: pyrC; PRK09357 633147003227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633147003228 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 633147003229 active site 633147003230 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 633147003231 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633147003232 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633147003233 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 633147003234 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147003235 active site 633147003236 putative glycosyl transferase; Provisional; Region: PRK10073 633147003237 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147003238 active site 633147003239 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 633147003240 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 633147003241 Walker A/P-loop; other site 633147003242 ATP binding site [chemical binding]; other site 633147003243 Q-loop/lid; other site 633147003244 ABC transporter signature motif; other site 633147003245 Walker B; other site 633147003246 D-loop; other site 633147003247 H-loop/switch region; other site 633147003248 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 633147003249 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 633147003250 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 633147003251 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 633147003252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633147003253 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 633147003254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633147003255 DNA binding residues [nucleotide binding] 633147003256 DNA primase; Validated; Region: dnaG; PRK05667 633147003257 CHC2 zinc finger; Region: zf-CHC2; pfam01807 633147003258 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 633147003259 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 633147003260 active site 633147003261 metal binding site [ion binding]; metal-binding site 633147003262 interdomain interaction site; other site 633147003263 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 633147003264 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 633147003265 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 633147003266 active site 633147003267 Riboflavin kinase; Region: Flavokinase; pfam01687 633147003268 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 633147003269 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 633147003270 RNA binding site [nucleotide binding]; other site 633147003271 active site 633147003272 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 633147003273 DHH family; Region: DHH; pfam01368 633147003274 Ribosome-binding factor A; Region: RBFA; pfam02033 633147003275 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633147003276 translation initiation factor IF-2; Region: IF-2; TIGR00487 633147003277 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 633147003278 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 633147003279 G1 box; other site 633147003280 putative GEF interaction site [polypeptide binding]; other site 633147003281 GTP/Mg2+ binding site [chemical binding]; other site 633147003282 Switch I region; other site 633147003283 G2 box; other site 633147003284 G3 box; other site 633147003285 Switch II region; other site 633147003286 G4 box; other site 633147003287 G5 box; other site 633147003288 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 633147003289 Translation-initiation factor 2; Region: IF-2; pfam11987 633147003290 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 633147003291 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 633147003292 NusA N-terminal domain; Region: NusA_N; pfam08529 633147003293 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 633147003294 RNA binding site [nucleotide binding]; other site 633147003295 homodimer interface [polypeptide binding]; other site 633147003296 NusA-like KH domain; Region: KH_5; pfam13184 633147003297 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 633147003298 G-X-X-G motif; other site 633147003299 Sm and related proteins; Region: Sm_like; cl00259 633147003300 ribosome maturation protein RimP; Reviewed; Region: PRK00092 633147003301 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 633147003302 putative oligomer interface [polypeptide binding]; other site 633147003303 putative RNA binding site [nucleotide binding]; other site 633147003304 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 633147003305 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 633147003306 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633147003307 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 633147003308 catalytic loop [active] 633147003309 iron binding site [ion binding]; other site 633147003310 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 633147003311 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 633147003312 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 633147003313 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633147003314 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 633147003315 Predicted oxidoreductase [General function prediction only]; Region: COG3573 633147003316 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 633147003317 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 633147003318 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 633147003319 Predicted acyl esterases [General function prediction only]; Region: COG2936 633147003320 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 633147003321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147003322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147003323 acyl carrier protein; Provisional; Region: acpP; PRK00982 633147003324 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; pfam01515 633147003325 butyrate kinase; Provisional; Region: PRK03011 633147003326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147003327 putative substrate translocation pore; other site 633147003328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147003329 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633147003330 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 633147003331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633147003332 NAD(P) binding site [chemical binding]; other site 633147003333 active site 633147003334 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 633147003335 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 633147003336 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633147003337 HIGH motif; other site 633147003338 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 633147003339 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 633147003340 active site 633147003341 KMSKS motif; other site 633147003342 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 633147003343 tRNA binding surface [nucleotide binding]; other site 633147003344 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 633147003345 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 633147003346 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147003347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147003348 active site 633147003349 phosphorylation site [posttranslational modification] 633147003350 intermolecular recognition site; other site 633147003351 dimerization interface [polypeptide binding]; other site 633147003352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147003353 DNA binding site [nucleotide binding] 633147003354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147003355 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147003356 dimer interface [polypeptide binding]; other site 633147003357 phosphorylation site [posttranslational modification] 633147003358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147003359 ATP binding site [chemical binding]; other site 633147003360 Mg2+ binding site [ion binding]; other site 633147003361 G-X-G motif; other site 633147003362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147003363 Major Facilitator Superfamily; Region: MFS_1; pfam07690 633147003364 putative substrate translocation pore; other site 633147003365 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 633147003366 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 633147003367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147003368 FeS/SAM binding site; other site 633147003369 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 633147003370 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 633147003371 Tetratricopeptide repeat; Region: TPR_12; pfam13424 633147003372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147003373 binding surface 633147003374 TPR motif; other site 633147003375 Tetratricopeptide repeat; Region: TPR_12; pfam13424 633147003376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147003377 binding surface 633147003378 TPR motif; other site 633147003379 Tetratricopeptide repeat; Region: TPR_12; pfam13424 633147003380 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 633147003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147003382 Walker A motif; other site 633147003383 ATP binding site [chemical binding]; other site 633147003384 Walker B motif; other site 633147003385 arginine finger; other site 633147003386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147003387 Walker A motif; other site 633147003388 ATP binding site [chemical binding]; other site 633147003389 Walker B motif; other site 633147003390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 633147003391 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 633147003392 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 633147003393 ligand binding site [chemical binding]; other site 633147003394 flexible hinge region; other site 633147003395 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 633147003396 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 633147003397 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 633147003398 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 633147003399 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 633147003400 active site 633147003401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 633147003402 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 633147003403 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 633147003404 DXD motif; other site 633147003405 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633147003406 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633147003407 RNA binding surface [nucleotide binding]; other site 633147003408 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633147003409 active site 633147003410 lipoprotein signal peptidase; Provisional; Region: PRK14787 633147003411 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 633147003412 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 633147003413 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 633147003414 active site 633147003415 HIGH motif; other site 633147003416 nucleotide binding site [chemical binding]; other site 633147003417 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 633147003418 active site 633147003419 KMSKS motif; other site 633147003420 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 633147003421 tRNA binding surface [nucleotide binding]; other site 633147003422 anticodon binding site; other site 633147003423 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 633147003424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 633147003425 FtsH Extracellular; Region: FtsH_ext; pfam06480 633147003426 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 633147003427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147003428 Walker A motif; other site 633147003429 ATP binding site [chemical binding]; other site 633147003430 Walker B motif; other site 633147003431 arginine finger; other site 633147003432 Peptidase family M41; Region: Peptidase_M41; pfam01434 633147003433 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 633147003434 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 633147003435 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 633147003436 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 633147003437 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 633147003438 signal recognition particle protein; Provisional; Region: PRK10867 633147003439 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 633147003440 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633147003441 P loop; other site 633147003442 GTP binding site [chemical binding]; other site 633147003443 Signal peptide binding domain; Region: SRP_SPB; pfam02978 633147003444 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 633147003445 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 633147003446 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 633147003447 P loop; other site 633147003448 GTP binding site [chemical binding]; other site 633147003449 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 633147003450 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 633147003451 Walker A/P-loop; other site 633147003452 ATP binding site [chemical binding]; other site 633147003453 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 633147003454 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 633147003455 ABC transporter signature motif; other site 633147003456 Walker B; other site 633147003457 D-loop; other site 633147003458 H-loop/switch region; other site 633147003459 ribonuclease III; Reviewed; Region: rnc; PRK00102 633147003460 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 633147003461 dimerization interface [polypeptide binding]; other site 633147003462 active site 633147003463 metal binding site [ion binding]; metal-binding site 633147003464 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 633147003465 dsRNA binding site [nucleotide binding]; other site 633147003466 acyl carrier protein; Provisional; Region: acpP; PRK00982 633147003467 putative phosphate acyltransferase; Provisional; Region: PRK05331 633147003468 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 633147003469 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 633147003470 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 633147003471 RHS Repeat; Region: RHS_repeat; cl11982 633147003472 RHS Repeat; Region: RHS_repeat; pfam05593 633147003473 RHS Repeat; Region: RHS_repeat; cl11982 633147003474 RHS Repeat; Region: RHS_repeat; cl11982 633147003475 RHS Repeat; Region: RHS_repeat; pfam05593 633147003476 RHS Repeat; Region: RHS_repeat; pfam05593 633147003477 RHS Repeat; Region: RHS_repeat; pfam05593 633147003478 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 633147003479 RHS Repeat; Region: RHS_repeat; cl11982 633147003480 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 633147003481 RHS Repeat; Region: RHS_repeat; cl11982 633147003482 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 633147003483 Putative amidase domain; Region: Amidase_6; pfam12671 633147003484 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 633147003485 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 633147003486 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 633147003487 active site 633147003488 (T/H)XGH motif; other site 633147003489 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 633147003490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147003491 S-adenosylmethionine binding site [chemical binding]; other site 633147003492 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 633147003493 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 633147003494 generic binding surface II; other site 633147003495 ssDNA binding site; other site 633147003496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147003497 ATP binding site [chemical binding]; other site 633147003498 putative Mg++ binding site [ion binding]; other site 633147003499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147003500 nucleotide binding region [chemical binding]; other site 633147003501 ATP-binding site [chemical binding]; other site 633147003502 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 633147003503 DAK2 domain; Region: Dak2; pfam02734 633147003504 Asp23 family; Region: Asp23; pfam03780 633147003505 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 633147003506 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 633147003507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003508 motif II; other site 633147003509 Thiamine pyrophosphokinase; Region: TPK; cd07995 633147003510 active site 633147003511 dimerization interface [polypeptide binding]; other site 633147003512 thiamine binding site [chemical binding]; other site 633147003513 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 633147003514 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 633147003515 putative RNA binding site [nucleotide binding]; other site 633147003516 16S rRNA methyltransferase B; Provisional; Region: PRK14902 633147003517 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 633147003518 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 633147003519 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 633147003520 putative active site [active] 633147003521 substrate binding site [chemical binding]; other site 633147003522 putative cosubstrate binding site; other site 633147003523 catalytic site [active] 633147003524 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 633147003525 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 633147003526 active site 633147003527 catalytic residues [active] 633147003528 metal binding site [ion binding]; metal-binding site 633147003529 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 633147003530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147003531 ATP binding site [chemical binding]; other site 633147003532 putative Mg++ binding site [ion binding]; other site 633147003533 helicase superfamily c-terminal domain; Region: HELICc; smart00490 633147003534 S-adenosylmethionine synthetase; Validated; Region: PRK05250 633147003535 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 633147003536 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 633147003537 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 633147003538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147003539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147003540 Predicted membrane protein [Function unknown]; Region: COG1511 633147003541 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 633147003542 Predicted membrane protein [Function unknown]; Region: COG1511 633147003543 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 633147003544 Predicted membrane protein [Function unknown]; Region: COG1511 633147003545 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 633147003546 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 633147003547 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 633147003548 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633147003549 active site 633147003550 HIGH motif; other site 633147003551 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 633147003552 active site 633147003553 KMSKS motif; other site 633147003554 RelB antitoxin; Region: RelB; cl01171 633147003555 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 633147003556 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 633147003557 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 633147003558 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 633147003559 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 633147003560 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 633147003561 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 633147003562 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 633147003563 active site 633147003564 NTP binding site [chemical binding]; other site 633147003565 metal binding triad [ion binding]; metal-binding site 633147003566 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 633147003567 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147003568 Zn2+ binding site [ion binding]; other site 633147003569 Mg2+ binding site [ion binding]; other site 633147003570 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 633147003571 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633147003572 trimer interface [polypeptide binding]; other site 633147003573 active site 633147003574 G bulge; other site 633147003575 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 633147003576 trimer interface [polypeptide binding]; other site 633147003577 active site 633147003578 G bulge; other site 633147003579 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 633147003580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003581 motif II; other site 633147003582 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 633147003583 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 633147003584 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 633147003585 DivIVA protein; Region: DivIVA; pfam05103 633147003586 DivIVA domain; Region: DivI1A_domain; TIGR03544 633147003587 YGGT family; Region: YGGT; pfam02325 633147003588 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 633147003589 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 633147003590 Protein of unknown function (DUF552); Region: DUF552; pfam04472 633147003591 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 633147003592 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 633147003593 catalytic residue [active] 633147003594 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 633147003595 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 633147003596 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 633147003597 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 633147003598 nucleotide binding site [chemical binding]; other site 633147003599 SulA interaction site; other site 633147003600 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 633147003601 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 633147003602 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 633147003603 FAD binding domain; Region: FAD_binding_4; pfam01565 633147003604 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 633147003605 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 633147003606 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633147003607 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633147003608 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633147003609 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 633147003610 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 633147003611 active site 633147003612 homodimer interface [polypeptide binding]; other site 633147003613 cell division protein FtsW; Region: ftsW; TIGR02614 633147003614 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 633147003615 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633147003616 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633147003617 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 633147003618 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 633147003619 Mg++ binding site [ion binding]; other site 633147003620 putative catalytic motif [active] 633147003621 putative substrate binding site [chemical binding]; other site 633147003622 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 633147003623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633147003624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633147003625 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 633147003626 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633147003627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633147003628 Cell division protein FtsL; Region: FtsL; cl11433 633147003629 MraW methylase family; Region: Methyltransf_5; cl17771 633147003630 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 633147003631 MraZ protein; Region: MraZ; pfam02381 633147003632 cell division protein MraZ; Reviewed; Region: PRK00326 633147003633 MraZ protein; Region: MraZ; pfam02381 633147003634 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 633147003635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633147003636 active site 633147003637 DNA binding site [nucleotide binding] 633147003638 Int/Topo IB signature motif; other site 633147003639 CTP synthetase; Validated; Region: pyrG; PRK05380 633147003640 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 633147003641 Catalytic site [active] 633147003642 active site 633147003643 UTP binding site [chemical binding]; other site 633147003644 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 633147003645 active site 633147003646 putative oxyanion hole; other site 633147003647 catalytic triad [active] 633147003648 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 633147003649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147003650 Walker A/P-loop; other site 633147003651 ATP binding site [chemical binding]; other site 633147003652 Q-loop/lid; other site 633147003653 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 633147003654 ABC transporter signature motif; other site 633147003655 Walker B; other site 633147003656 D-loop; other site 633147003657 H-loop/switch region; other site 633147003658 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 633147003659 ATP-NAD kinase; Region: NAD_kinase; pfam01513 633147003660 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 633147003661 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633147003662 RNA binding surface [nucleotide binding]; other site 633147003663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 633147003664 S-adenosylmethionine binding site [chemical binding]; other site 633147003665 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 633147003666 putative RNA binding site [nucleotide binding]; other site 633147003667 Asp23 family; Region: Asp23; cl00574 633147003668 elongation factor P; Validated; Region: PRK00529 633147003669 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 633147003670 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 633147003671 RNA binding site [nucleotide binding]; other site 633147003672 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 633147003673 RNA binding site [nucleotide binding]; other site 633147003674 Domain of unknown function (DUF956); Region: DUF956; pfam06115 633147003675 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 633147003676 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 633147003677 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633147003678 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633147003679 active pocket/dimerization site; other site 633147003680 active site 633147003681 phosphorylation site [posttranslational modification] 633147003682 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 633147003683 active site 633147003684 phosphorylation site [posttranslational modification] 633147003685 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147003686 domain interaction interfaces [polypeptide binding]; other site 633147003687 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147003688 domain interaction interfaces [polypeptide binding]; other site 633147003689 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147003690 domain interaction interfaces [polypeptide binding]; other site 633147003691 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147003692 domain interaction interfaces [polypeptide binding]; other site 633147003693 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633147003694 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633147003695 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633147003696 active site 633147003697 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633147003698 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633147003699 metal binding site [ion binding]; metal-binding site 633147003700 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 633147003701 Shikimate kinase; Region: SKI; pfam01202 633147003702 ADP binding site [chemical binding]; other site 633147003703 magnesium binding site [ion binding]; other site 633147003704 putative shikimate binding site; other site 633147003705 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 633147003706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003707 motif II; other site 633147003708 YceG-like family; Region: YceG; pfam02618 633147003709 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 633147003710 dimerization interface [polypeptide binding]; other site 633147003711 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 633147003712 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 633147003713 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 633147003714 motif 1; other site 633147003715 active site 633147003716 motif 2; other site 633147003717 motif 3; other site 633147003718 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 633147003719 DHHA1 domain; Region: DHHA1; pfam02272 633147003720 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 633147003721 Domain of unknown function DUF20; Region: UPF0118; pfam01594 633147003722 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 633147003723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 633147003724 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 633147003725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 633147003726 DNA binding residues [nucleotide binding] 633147003727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 633147003728 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 633147003729 recombination factor protein RarA; Reviewed; Region: PRK13342 633147003730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147003731 Walker A motif; other site 633147003732 ATP binding site [chemical binding]; other site 633147003733 Walker B motif; other site 633147003734 arginine finger; other site 633147003735 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 633147003736 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 633147003737 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 633147003738 Zn2+ binding site [ion binding]; other site 633147003739 Mg2+ binding site [ion binding]; other site 633147003740 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 633147003741 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 633147003742 active site 633147003743 catalytic triad [active] 633147003744 oxyanion hole [active] 633147003745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633147003746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 633147003747 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 633147003748 active site 633147003749 metal binding site [ion binding]; metal-binding site 633147003750 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 633147003751 additional DNA contacts [nucleotide binding]; other site 633147003752 mismatch recognition site; other site 633147003753 active site 633147003754 zinc binding site [ion binding]; other site 633147003755 DNA intercalation site [nucleotide binding]; other site 633147003756 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 633147003757 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 633147003758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 633147003759 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633147003760 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003761 active site 633147003762 motif I; other site 633147003763 motif II; other site 633147003764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003765 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 633147003766 metal ion-dependent adhesion site (MIDAS); other site 633147003767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147003768 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 633147003769 Walker A motif; other site 633147003770 ATP binding site [chemical binding]; other site 633147003771 Walker B motif; other site 633147003772 arginine finger; other site 633147003773 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 633147003774 Uncharacterized conserved protein [Function unknown]; Region: COG2461 633147003775 Family of unknown function (DUF438); Region: DUF438; pfam04282 633147003776 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 633147003777 PAS domain; Region: PAS_10; pfam13596 633147003778 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 633147003779 FtsX-like permease family; Region: FtsX; pfam02687 633147003780 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 633147003781 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633147003782 FtsX-like permease family; Region: FtsX; pfam02687 633147003783 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633147003784 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633147003785 Walker A/P-loop; other site 633147003786 ATP binding site [chemical binding]; other site 633147003787 Q-loop/lid; other site 633147003788 ABC transporter signature motif; other site 633147003789 Walker B; other site 633147003790 D-loop; other site 633147003791 H-loop/switch region; other site 633147003792 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147003793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147003794 DNA-binding site [nucleotide binding]; DNA binding site 633147003795 UTRA domain; Region: UTRA; pfam07702 633147003796 YolD-like protein; Region: YolD; pfam08863 633147003797 DNA polymerase IV; Reviewed; Region: PRK03103 633147003798 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 633147003799 active site 633147003800 DNA binding site [nucleotide binding] 633147003801 DJ-1 family protein; Region: not_thiJ; TIGR01383 633147003802 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 633147003803 conserved cys residue [active] 633147003804 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 633147003805 L-lactate permease; Region: Lactate_perm; cl00701 633147003806 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 633147003807 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 633147003808 Peptidase family C69; Region: Peptidase_C69; pfam03577 633147003809 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 633147003810 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 633147003811 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 633147003812 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 633147003813 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 633147003814 AzlC protein; Region: AzlC; pfam03591 633147003815 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147003816 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147003817 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633147003818 dimerization interface [polypeptide binding]; other site 633147003819 Protein of unknown function (DUF328); Region: DUF328; pfam03883 633147003820 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 633147003821 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 633147003822 HPr interaction site; other site 633147003823 glycerol kinase (GK) interaction site [polypeptide binding]; other site 633147003824 active site 633147003825 phosphorylation site [posttranslational modification] 633147003826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 633147003827 hypothetical protein; Provisional; Region: PRK13663 633147003828 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 633147003829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147003830 Walker A/P-loop; other site 633147003831 ATP binding site [chemical binding]; other site 633147003832 Q-loop/lid; other site 633147003833 ABC transporter signature motif; other site 633147003834 Walker B; other site 633147003835 D-loop; other site 633147003836 H-loop/switch region; other site 633147003837 TOBE domain; Region: TOBE_2; pfam08402 633147003838 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 633147003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147003840 putative PBP binding loops; other site 633147003841 dimer interface [polypeptide binding]; other site 633147003842 ABC-ATPase subunit interface; other site 633147003843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147003844 dimer interface [polypeptide binding]; other site 633147003845 conserved gate region; other site 633147003846 putative PBP binding loops; other site 633147003847 ABC-ATPase subunit interface; other site 633147003848 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 633147003849 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 633147003850 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 633147003851 Zn binding site [ion binding]; other site 633147003852 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 633147003853 active site 633147003854 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147003855 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147003856 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633147003857 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147003858 putative DNA binding site [nucleotide binding]; other site 633147003859 putative Zn2+ binding site [ion binding]; other site 633147003860 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 633147003861 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 633147003862 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 633147003863 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 633147003864 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 633147003865 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 633147003866 trimer interface [polypeptide binding]; other site 633147003867 active site 633147003868 substrate binding site [chemical binding]; other site 633147003869 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 633147003870 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 633147003871 dimer interface [polypeptide binding]; other site 633147003872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147003873 catalytic residue [active] 633147003874 6-phosphofructokinase; Provisional; Region: PRK03202 633147003875 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 633147003876 active site 633147003877 ADP/pyrophosphate binding site [chemical binding]; other site 633147003878 dimerization interface [polypeptide binding]; other site 633147003879 allosteric effector site; other site 633147003880 fructose-1,6-bisphosphate binding site; other site 633147003881 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 633147003882 dimer interface [polypeptide binding]; other site 633147003883 active site 633147003884 metal binding site [ion binding]; metal-binding site 633147003885 glutathione binding site [chemical binding]; other site 633147003886 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 633147003887 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 633147003888 active site 633147003889 catalytic site [active] 633147003890 substrate binding site [chemical binding]; other site 633147003891 heat shock protein 90; Provisional; Region: PRK05218 633147003892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147003893 ATP binding site [chemical binding]; other site 633147003894 Mg2+ binding site [ion binding]; other site 633147003895 G-X-G motif; other site 633147003896 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 633147003897 catalytic motif [active] 633147003898 Zn binding site [ion binding]; other site 633147003899 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 633147003900 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 633147003901 catalytic triad [active] 633147003902 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 633147003903 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633147003904 helix-hairpin-helix signature motif; other site 633147003905 active site 633147003906 Restriction endonuclease NotI; Region: NotI; pfam12183 633147003907 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 633147003908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147003909 non-specific DNA binding site [nucleotide binding]; other site 633147003910 salt bridge; other site 633147003911 sequence-specific DNA binding site [nucleotide binding]; other site 633147003912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633147003913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147003914 homodimer interface [polypeptide binding]; other site 633147003915 catalytic residue [active] 633147003916 Predicted flavoprotein [General function prediction only]; Region: COG0431 633147003917 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 633147003918 Predicted permeases [General function prediction only]; Region: COG0679 633147003919 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 633147003920 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 633147003921 ATP-grasp domain; Region: ATP-grasp_4; cl17255 633147003922 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 633147003923 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 633147003924 dimer interface [polypeptide binding]; other site 633147003925 active site 633147003926 glycine loop; other site 633147003927 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 633147003928 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147003929 FeS/SAM binding site; other site 633147003930 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 633147003931 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 633147003932 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633147003933 methionine aminopeptidase; Provisional; Region: PRK12318 633147003934 SEC-C motif; Region: SEC-C; pfam02810 633147003935 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 633147003936 active site 633147003937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 633147003938 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 633147003939 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 633147003940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147003941 active site 633147003942 motif I; other site 633147003943 motif II; other site 633147003944 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 633147003945 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 633147003946 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 633147003947 active site turn [active] 633147003948 phosphorylation site [posttranslational modification] 633147003949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147003950 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 633147003951 DNA-binding site [nucleotide binding]; DNA binding site 633147003952 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633147003953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147003954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147003955 dimer interface [polypeptide binding]; other site 633147003956 phosphorylation site [posttranslational modification] 633147003957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147003958 ATP binding site [chemical binding]; other site 633147003959 G-X-G motif; other site 633147003960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147003962 active site 633147003963 phosphorylation site [posttranslational modification] 633147003964 intermolecular recognition site; other site 633147003965 dimerization interface [polypeptide binding]; other site 633147003966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147003967 DNA binding site [nucleotide binding] 633147003968 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 633147003969 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 633147003970 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 633147003971 acyl-activating enzyme (AAE) consensus motif; other site 633147003972 AMP binding site [chemical binding]; other site 633147003973 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 633147003974 Phosphopantetheine attachment site; Region: PP-binding; cl09936 633147003975 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 633147003976 DltD C-terminal region; Region: DltD_C; pfam04914 633147003977 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 633147003978 putative uracil binding site [chemical binding]; other site 633147003979 putative active site [active] 633147003980 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 633147003981 synthetase active site [active] 633147003982 NTP binding site [chemical binding]; other site 633147003983 metal binding site [ion binding]; metal-binding site 633147003984 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147003985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147003986 dimer interface [polypeptide binding]; other site 633147003987 phosphorylation site [posttranslational modification] 633147003988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147003989 ATP binding site [chemical binding]; other site 633147003990 Mg2+ binding site [ion binding]; other site 633147003991 G-X-G motif; other site 633147003992 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147003993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147003994 active site 633147003995 phosphorylation site [posttranslational modification] 633147003996 intermolecular recognition site; other site 633147003997 dimerization interface [polypeptide binding]; other site 633147003998 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633147003999 FtsX-like permease family; Region: FtsX; pfam02687 633147004000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633147004001 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633147004002 Walker A/P-loop; other site 633147004003 ATP binding site [chemical binding]; other site 633147004004 Q-loop/lid; other site 633147004005 ABC transporter signature motif; other site 633147004006 Walker B; other site 633147004007 D-loop; other site 633147004008 H-loop/switch region; other site 633147004009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147004010 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 633147004011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147004012 ATP binding site [chemical binding]; other site 633147004013 Mg2+ binding site [ion binding]; other site 633147004014 G-X-G motif; other site 633147004015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147004016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147004017 active site 633147004018 phosphorylation site [posttranslational modification] 633147004019 intermolecular recognition site; other site 633147004020 dimerization interface [polypeptide binding]; other site 633147004021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147004022 DNA binding site [nucleotide binding] 633147004023 YhhN-like protein; Region: YhhN; cl01505 633147004024 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 633147004025 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 633147004026 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 633147004027 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147004028 non-specific DNA binding site [nucleotide binding]; other site 633147004029 salt bridge; other site 633147004030 sequence-specific DNA binding site [nucleotide binding]; other site 633147004031 Phage Terminase; Region: Terminase_1; pfam03354 633147004032 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09644 633147004033 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 633147004034 tetramer interface [polypeptide binding]; other site 633147004035 putative DNA binding site [nucleotide binding]; other site 633147004036 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 633147004037 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 633147004038 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 633147004039 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 633147004040 thymidine kinase; Provisional; Region: PRK04296 633147004041 Protein of unknown function (DUF419); Region: DUF419; cl15265 633147004042 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 633147004043 phosphate binding site [ion binding]; other site 633147004044 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 633147004045 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 633147004046 active site 633147004047 NAD binding site [chemical binding]; other site 633147004048 metal binding site [ion binding]; metal-binding site 633147004049 BtpA family; Region: BtpA; cl00440 633147004050 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633147004051 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147004052 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 633147004053 substrate binding site [chemical binding]; other site 633147004054 ATP binding site [chemical binding]; other site 633147004055 Isochorismatase family; Region: Isochorismatase; pfam00857 633147004056 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 633147004057 catalytic triad [active] 633147004058 conserved cis-peptide bond; other site 633147004059 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147004060 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 633147004061 TM-ABC transporter signature motif; other site 633147004062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 633147004063 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 633147004064 TM-ABC transporter signature motif; other site 633147004065 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 633147004066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004067 Walker A/P-loop; other site 633147004068 ATP binding site [chemical binding]; other site 633147004069 Q-loop/lid; other site 633147004070 ABC transporter signature motif; other site 633147004071 Walker B; other site 633147004072 D-loop; other site 633147004073 H-loop/switch region; other site 633147004074 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 633147004075 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 633147004076 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147004077 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147004078 DNA-binding site [nucleotide binding]; DNA binding site 633147004079 UTRA domain; Region: UTRA; pfam07702 633147004080 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 633147004081 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 633147004082 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 633147004083 Ligand Binding Site [chemical binding]; other site 633147004084 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147004085 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 633147004086 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147004087 catalytic residue [active] 633147004088 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 633147004089 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 633147004090 anti sigma factor interaction site; other site 633147004091 regulatory phosphorylation site [posttranslational modification]; other site 633147004092 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 633147004093 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 633147004094 Mg2+ binding site [ion binding]; other site 633147004095 G-X-G motif; other site 633147004096 GAF domain; Region: GAF_2; pfam13185 633147004097 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 633147004098 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 633147004099 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 633147004100 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004101 Walker A/P-loop; other site 633147004102 ATP binding site [chemical binding]; other site 633147004103 Q-loop/lid; other site 633147004104 ABC transporter signature motif; other site 633147004105 Walker B; other site 633147004106 D-loop; other site 633147004107 H-loop/switch region; other site 633147004108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633147004109 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633147004110 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004111 Walker A/P-loop; other site 633147004112 ATP binding site [chemical binding]; other site 633147004113 Q-loop/lid; other site 633147004114 ABC transporter signature motif; other site 633147004115 Walker B; other site 633147004116 D-loop; other site 633147004117 H-loop/switch region; other site 633147004118 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 633147004119 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 633147004120 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 633147004121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004122 dimer interface [polypeptide binding]; other site 633147004123 conserved gate region; other site 633147004124 putative PBP binding loops; other site 633147004125 ABC-ATPase subunit interface; other site 633147004126 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633147004127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004128 dimer interface [polypeptide binding]; other site 633147004129 conserved gate region; other site 633147004130 putative PBP binding loops; other site 633147004131 ABC-ATPase subunit interface; other site 633147004132 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 633147004133 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633147004134 Preprotein translocase SecG subunit; Region: SecG; pfam03840 633147004135 triosephosphate isomerase; Provisional; Region: PRK14567 633147004136 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 633147004137 substrate binding site [chemical binding]; other site 633147004138 dimer interface [polypeptide binding]; other site 633147004139 catalytic triad [active] 633147004140 Phosphoglycerate kinase; Region: PGK; pfam00162 633147004141 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 633147004142 substrate binding site [chemical binding]; other site 633147004143 hinge regions; other site 633147004144 ADP binding site [chemical binding]; other site 633147004145 catalytic site [active] 633147004146 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 633147004147 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 633147004148 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 633147004149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 633147004150 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 633147004151 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 633147004152 AAA domain; Region: AAA_33; pfam13671 633147004153 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 633147004154 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 633147004155 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 633147004156 putative active site [active] 633147004157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 633147004158 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 633147004159 NAD(P) binding site [chemical binding]; other site 633147004160 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633147004161 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633147004162 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 633147004163 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 633147004164 active pocket/dimerization site; other site 633147004165 active site 633147004166 phosphorylation site [posttranslational modification] 633147004167 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633147004168 active site 633147004169 phosphorylation site [posttranslational modification] 633147004170 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 633147004171 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 633147004172 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 633147004173 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 633147004174 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 633147004175 putative active site cavity [active] 633147004176 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 633147004177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 633147004178 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 633147004179 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 633147004180 inhibitor site; inhibition site 633147004181 active site 633147004182 dimer interface [polypeptide binding]; other site 633147004183 catalytic residue [active] 633147004184 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 633147004185 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 633147004186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633147004187 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 633147004188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004189 Walker A/P-loop; other site 633147004190 ATP binding site [chemical binding]; other site 633147004191 Q-loop/lid; other site 633147004192 ABC transporter signature motif; other site 633147004193 Walker B; other site 633147004194 D-loop; other site 633147004195 H-loop/switch region; other site 633147004196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 633147004197 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 633147004198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004199 dimer interface [polypeptide binding]; other site 633147004200 conserved gate region; other site 633147004201 putative PBP binding loops; other site 633147004202 ABC-ATPase subunit interface; other site 633147004203 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633147004204 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004205 Walker A/P-loop; other site 633147004206 ATP binding site [chemical binding]; other site 633147004207 Q-loop/lid; other site 633147004208 ABC transporter signature motif; other site 633147004209 Walker B; other site 633147004210 D-loop; other site 633147004211 H-loop/switch region; other site 633147004212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 633147004213 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633147004214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004215 dimer interface [polypeptide binding]; other site 633147004216 conserved gate region; other site 633147004217 putative PBP binding loops; other site 633147004218 ABC-ATPase subunit interface; other site 633147004219 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 633147004220 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633147004221 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 633147004222 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 633147004223 GIY-YIG motif/motif A; other site 633147004224 active site 633147004225 catalytic site [active] 633147004226 putative DNA binding site [nucleotide binding]; other site 633147004227 metal binding site [ion binding]; metal-binding site 633147004228 UvrB/uvrC motif; Region: UVR; pfam02151 633147004229 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 633147004230 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 633147004231 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 633147004232 aspartate racemase; Region: asp_race; TIGR00035 633147004233 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 633147004234 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 633147004235 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 633147004236 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 633147004237 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 633147004238 substrate binding site [chemical binding]; other site 633147004239 glutamase interaction surface [polypeptide binding]; other site 633147004240 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 633147004241 catalytic residues [active] 633147004242 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 633147004243 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 633147004244 putative active site [active] 633147004245 oxyanion strand; other site 633147004246 catalytic triad [active] 633147004247 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 633147004248 putative active site pocket [active] 633147004249 4-fold oligomerization interface [polypeptide binding]; other site 633147004250 metal binding residues [ion binding]; metal-binding site 633147004251 3-fold/trimer interface [polypeptide binding]; other site 633147004252 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 633147004253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 633147004254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 633147004255 homodimer interface [polypeptide binding]; other site 633147004256 catalytic residue [active] 633147004257 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 633147004258 histidinol dehydrogenase; Region: hisD; TIGR00069 633147004259 NAD binding site [chemical binding]; other site 633147004260 dimerization interface [polypeptide binding]; other site 633147004261 product binding site; other site 633147004262 substrate binding site [chemical binding]; other site 633147004263 zinc binding site [ion binding]; other site 633147004264 catalytic residues [active] 633147004265 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 633147004266 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 633147004267 dimer interface [polypeptide binding]; other site 633147004268 motif 1; other site 633147004269 active site 633147004270 motif 2; other site 633147004271 motif 3; other site 633147004272 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 633147004273 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 633147004274 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 633147004275 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 633147004276 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 633147004277 putative deacylase active site [active] 633147004278 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 633147004279 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633147004280 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 633147004281 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 633147004282 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 633147004283 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147004284 salt bridge; other site 633147004285 non-specific DNA binding site [nucleotide binding]; other site 633147004286 sequence-specific DNA binding site [nucleotide binding]; other site 633147004287 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 633147004288 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 633147004289 flavoprotein, HI0933 family; Region: TIGR00275 633147004290 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 633147004291 Peptidase family C69; Region: Peptidase_C69; cl17793 633147004292 Immunoglobulin domain; Region: Ig; cl11960 633147004293 excinuclease ABC subunit B; Provisional; Region: PRK05298 633147004294 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147004295 ATP binding site [chemical binding]; other site 633147004296 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147004297 nucleotide binding region [chemical binding]; other site 633147004298 ATP-binding site [chemical binding]; other site 633147004299 Ultra-violet resistance protein B; Region: UvrB; pfam12344 633147004300 UvrB/uvrC motif; Region: UVR; pfam02151 633147004301 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 633147004302 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 633147004303 N-acetyl-D-glucosamine binding site [chemical binding]; other site 633147004304 catalytic residue [active] 633147004305 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 633147004306 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 633147004307 CoA-binding site [chemical binding]; other site 633147004308 ATP-binding [chemical binding]; other site 633147004309 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 633147004310 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 633147004311 metal binding site [ion binding]; metal-binding site 633147004312 peptidase T; Region: peptidase-T; TIGR01882 633147004313 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 633147004314 metal binding site [ion binding]; metal-binding site 633147004315 dimer interface [polypeptide binding]; other site 633147004316 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 633147004317 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633147004318 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 633147004319 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004320 Walker A/P-loop; other site 633147004321 ATP binding site [chemical binding]; other site 633147004322 Q-loop/lid; other site 633147004323 ABC transporter signature motif; other site 633147004324 Walker B; other site 633147004325 D-loop; other site 633147004326 H-loop/switch region; other site 633147004327 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 633147004328 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 633147004329 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 633147004330 Walker A/P-loop; other site 633147004331 ATP binding site [chemical binding]; other site 633147004332 Q-loop/lid; other site 633147004333 ABC transporter signature motif; other site 633147004334 Walker B; other site 633147004335 D-loop; other site 633147004336 H-loop/switch region; other site 633147004337 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 633147004338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 633147004339 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 633147004340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004341 dimer interface [polypeptide binding]; other site 633147004342 conserved gate region; other site 633147004343 putative PBP binding loops; other site 633147004344 ABC-ATPase subunit interface; other site 633147004345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 633147004346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004347 dimer interface [polypeptide binding]; other site 633147004348 conserved gate region; other site 633147004349 putative PBP binding loops; other site 633147004350 ABC-ATPase subunit interface; other site 633147004351 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 633147004352 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 633147004353 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 633147004354 RNA binding site [nucleotide binding]; other site 633147004355 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 633147004356 RNA binding site [nucleotide binding]; other site 633147004357 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 633147004358 RNA binding site [nucleotide binding]; other site 633147004359 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 633147004360 RNA binding site [nucleotide binding]; other site 633147004361 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 633147004362 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 633147004363 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 633147004364 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633147004365 metal-binding site [ion binding] 633147004366 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 633147004367 RNA/DNA hybrid binding site [nucleotide binding]; other site 633147004368 active site 633147004369 DNA polymerase I; Provisional; Region: PRK05755 633147004370 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 633147004371 active site 633147004372 metal binding site 1 [ion binding]; metal-binding site 633147004373 putative 5' ssDNA interaction site; other site 633147004374 metal binding site 3; metal-binding site 633147004375 metal binding site 2 [ion binding]; metal-binding site 633147004376 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 633147004377 putative DNA binding site [nucleotide binding]; other site 633147004378 putative metal binding site [ion binding]; other site 633147004379 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 633147004380 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 633147004381 active site 633147004382 DNA binding site [nucleotide binding] 633147004383 catalytic site [active] 633147004384 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 633147004385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 633147004386 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 633147004387 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 633147004388 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633147004389 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 633147004390 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 633147004391 Putative esterase; Region: Esterase; pfam00756 633147004392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 633147004393 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 633147004394 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 633147004395 nucleotide binding pocket [chemical binding]; other site 633147004396 K-X-D-G motif; other site 633147004397 catalytic site [active] 633147004398 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 633147004399 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 633147004400 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 633147004401 Dimer interface [polypeptide binding]; other site 633147004402 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 633147004403 ligand binding site [chemical binding]; other site 633147004404 active site 633147004405 UGI interface [polypeptide binding]; other site 633147004406 catalytic site [active] 633147004407 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633147004408 metal-binding site [ion binding] 633147004409 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 633147004410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147004411 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633147004412 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 633147004413 metal-binding site [ion binding] 633147004414 C-terminal domain of Faecalibacterium prausnitzii A2-165 FrmR , and related domains; this domain family was previously known as part of DUF156; Region: FpFrmR-Cterm-like_DUF156; cd10156 633147004415 putative homodimer interface [polypeptide binding]; other site 633147004416 putative homotetramer interface [polypeptide binding]; other site 633147004417 putative allosteric switch controlling residues; other site 633147004418 putative metal binding site [ion binding]; other site 633147004419 putative homodimer-homodimer interface [polypeptide binding]; other site 633147004420 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 633147004421 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 633147004422 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 633147004423 protein binding site [polypeptide binding]; other site 633147004424 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147004425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147004426 DNA binding site [nucleotide binding] 633147004427 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633147004428 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633147004429 Walker A/P-loop; other site 633147004430 ATP binding site [chemical binding]; other site 633147004431 Q-loop/lid; other site 633147004432 ABC transporter signature motif; other site 633147004433 Walker B; other site 633147004434 D-loop; other site 633147004435 H-loop/switch region; other site 633147004436 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147004437 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147004438 substrate binding pocket [chemical binding]; other site 633147004439 membrane-bound complex binding site; other site 633147004440 hinge residues; other site 633147004441 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 633147004442 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633147004443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004444 dimer interface [polypeptide binding]; other site 633147004445 conserved gate region; other site 633147004446 putative PBP binding loops; other site 633147004447 ABC-ATPase subunit interface; other site 633147004448 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 633147004449 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 633147004450 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 633147004451 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 633147004452 Protein of unknown function (DUF3793); Region: DUF3793; pfam12672 633147004453 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 633147004454 substrate binding site [chemical binding]; other site 633147004455 THF binding site; other site 633147004456 zinc-binding site [ion binding]; other site 633147004457 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633147004458 FtsX-like permease family; Region: FtsX; pfam02687 633147004459 FtsX-like permease family; Region: FtsX; pfam02687 633147004460 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633147004461 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633147004462 Walker A/P-loop; other site 633147004463 ATP binding site [chemical binding]; other site 633147004464 Q-loop/lid; other site 633147004465 ABC transporter signature motif; other site 633147004466 Walker B; other site 633147004467 D-loop; other site 633147004468 H-loop/switch region; other site 633147004469 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 633147004470 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147004471 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 633147004472 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 633147004473 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 633147004474 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 633147004475 G1 box; other site 633147004476 GTP/Mg2+ binding site [chemical binding]; other site 633147004477 Switch I region; other site 633147004478 G2 box; other site 633147004479 G3 box; other site 633147004480 Switch II region; other site 633147004481 G4 box; other site 633147004482 G5 box; other site 633147004483 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 633147004484 Nucleoside recognition; Region: Gate; pfam07670 633147004485 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 633147004486 Nucleoside recognition; Region: Gate; pfam07670 633147004487 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 633147004488 FeoA domain; Region: FeoA; cl00838 633147004489 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 633147004490 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 633147004491 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 633147004492 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 633147004493 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 633147004494 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 633147004495 putative catalytic site [active] 633147004496 putative metal binding site [ion binding]; other site 633147004497 putative phosphate binding site [ion binding]; other site 633147004498 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 633147004499 GSH binding site [chemical binding]; other site 633147004500 catalytic residues [active] 633147004501 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 633147004502 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147004503 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004504 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633147004505 Walker A/P-loop; other site 633147004506 ATP binding site [chemical binding]; other site 633147004507 Q-loop/lid; other site 633147004508 ABC transporter signature motif; other site 633147004509 Walker B; other site 633147004510 D-loop; other site 633147004511 H-loop/switch region; other site 633147004512 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147004513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004515 Walker A/P-loop; other site 633147004516 ATP binding site [chemical binding]; other site 633147004517 Q-loop/lid; other site 633147004518 ABC transporter signature motif; other site 633147004519 Walker B; other site 633147004520 D-loop; other site 633147004521 H-loop/switch region; other site 633147004522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 633147004523 non-specific DNA binding site [nucleotide binding]; other site 633147004524 salt bridge; other site 633147004525 sequence-specific DNA binding site [nucleotide binding]; other site 633147004526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 633147004527 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004528 Walker A/P-loop; other site 633147004529 ATP binding site [chemical binding]; other site 633147004530 Q-loop/lid; other site 633147004531 ABC transporter signature motif; other site 633147004532 Walker B; other site 633147004533 D-loop; other site 633147004534 H-loop/switch region; other site 633147004535 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 633147004536 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 633147004537 dimer interface [polypeptide binding]; other site 633147004538 anticodon binding site; other site 633147004539 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633147004540 motif 1; other site 633147004541 dimer interface [polypeptide binding]; other site 633147004542 active site 633147004543 motif 2; other site 633147004544 GAD domain; Region: GAD; pfam02938 633147004545 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 633147004546 active site 633147004547 motif 3; other site 633147004548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 633147004549 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 633147004550 HlyD family secretion protein; Region: HlyD_3; pfam13437 633147004551 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 633147004552 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 633147004553 Walker A/P-loop; other site 633147004554 ATP binding site [chemical binding]; other site 633147004555 Q-loop/lid; other site 633147004556 ABC transporter signature motif; other site 633147004557 Walker B; other site 633147004558 D-loop; other site 633147004559 H-loop/switch region; other site 633147004560 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 633147004561 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 633147004562 FtsX-like permease family; Region: FtsX; pfam02687 633147004563 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 633147004564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147004565 motif II; other site 633147004566 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 633147004567 4Fe-4S binding domain; Region: Fer4_6; pfam12837 633147004568 4Fe-4S binding domain; Region: Fer4; pfam00037 633147004569 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 633147004570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 633147004571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 633147004572 active site 633147004573 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147004574 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147004575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633147004576 dimerization interface [polypeptide binding]; other site 633147004577 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 633147004578 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 633147004579 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 633147004580 dimer interface [polypeptide binding]; other site 633147004581 motif 1; other site 633147004582 active site 633147004583 motif 2; other site 633147004584 motif 3; other site 633147004585 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 633147004586 anticodon binding site; other site 633147004587 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 633147004588 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 633147004589 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 633147004590 homodimer interface [polypeptide binding]; other site 633147004591 substrate-cofactor binding pocket; other site 633147004592 catalytic residue [active] 633147004593 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 633147004594 HTH domain; Region: HTH_11; pfam08279 633147004595 3H domain; Region: 3H; pfam02829 633147004596 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 633147004597 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 633147004598 dimerization interface [polypeptide binding]; other site 633147004599 active site 633147004600 L-aspartate oxidase; Provisional; Region: PRK06175 633147004601 FAD binding domain; Region: FAD_binding_2; pfam00890 633147004602 Quinolinate synthetase A protein; Region: NadA; pfam02445 633147004603 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 633147004604 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 633147004605 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 633147004606 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 633147004607 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 633147004608 active site 633147004609 dimer interface [polypeptide binding]; other site 633147004610 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 633147004611 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 633147004612 substrate binding [chemical binding]; other site 633147004613 active site 633147004614 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 633147004615 AAA ATPase domain; Region: AAA_16; pfam13191 633147004616 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 633147004617 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 633147004618 dimer interface [polypeptide binding]; other site 633147004619 active site 633147004620 metal binding site [ion binding]; metal-binding site 633147004621 BtpA family; Region: BtpA; cl00440 633147004622 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 633147004623 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 633147004624 N- and C-terminal domain interface [polypeptide binding]; other site 633147004625 putative active site [active] 633147004626 MgATP binding site [chemical binding]; other site 633147004627 catalytic site [active] 633147004628 metal binding site [ion binding]; metal-binding site 633147004629 putative xylulose binding site [chemical binding]; other site 633147004630 putative homodimer interface [polypeptide binding]; other site 633147004631 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147004632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147004633 DNA-binding site [nucleotide binding]; DNA binding site 633147004634 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 633147004635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147004636 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147004637 DNA-binding site [nucleotide binding]; DNA binding site 633147004638 UTRA domain; Region: UTRA; pfam07702 633147004639 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 633147004640 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 633147004641 fructoselysine 3-epimerase; Provisional; Region: PRK09856 633147004642 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 633147004643 DNA interaction; other site 633147004644 Metal-binding active site; metal-binding site 633147004645 fructoselysine 6-kinase; Provisional; Region: PRK09813 633147004646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147004647 substrate binding site [chemical binding]; other site 633147004648 ATP binding site [chemical binding]; other site 633147004649 fructoselysine 6-kinase; Provisional; Region: PRK09813 633147004650 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147004651 substrate binding site [chemical binding]; other site 633147004652 ATP binding site [chemical binding]; other site 633147004653 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 633147004654 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147004655 substrate binding site [chemical binding]; other site 633147004656 ATP binding site [chemical binding]; other site 633147004657 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 633147004658 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 633147004659 inhibitor site; inhibition site 633147004660 active site 633147004661 dimer interface [polypeptide binding]; other site 633147004662 catalytic residue [active] 633147004663 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 633147004664 substrate binding site [chemical binding]; other site 633147004665 dimer interface [polypeptide binding]; other site 633147004666 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 633147004667 ATP binding site [chemical binding]; other site 633147004668 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 633147004669 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 633147004670 active site 633147004671 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 633147004672 S-formylglutathione hydrolase; Region: PLN02442 633147004673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147004674 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633147004675 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 633147004676 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 633147004677 AP (apurinic/apyrimidinic) site pocket; other site 633147004678 Metal-binding active site; metal-binding site 633147004679 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 633147004680 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 633147004681 putative active site [active] 633147004682 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 633147004683 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 633147004684 classical (c) SDRs; Region: SDR_c; cd05233 633147004685 NAD(P) binding site [chemical binding]; other site 633147004686 active site 633147004687 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 633147004688 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 633147004689 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 633147004690 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 633147004691 active site 633147004692 Protein of unknown function (DUF523); Region: DUF523; pfam04463 633147004693 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 633147004694 TfoX N-terminal domain; Region: TfoX_N; pfam04993 633147004695 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 633147004696 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 633147004697 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 633147004698 Uncharacterized conserved protein [Function unknown]; Region: COG1432 633147004699 LabA_like proteins; Region: LabA_like; cd06167 633147004700 putative metal binding site [ion binding]; other site 633147004701 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 633147004702 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 633147004703 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 633147004704 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147004705 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147004706 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 633147004707 30S subunit binding site; other site 633147004708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147004709 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147004710 substrate binding pocket [chemical binding]; other site 633147004711 membrane-bound complex binding site; other site 633147004712 hinge residues; other site 633147004713 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 633147004714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147004715 active site 633147004716 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 633147004717 active site 633147004718 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 633147004719 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 633147004720 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 633147004721 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 633147004722 active site 633147004723 HIGH motif; other site 633147004724 KMSKS motif; other site 633147004725 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 633147004726 tRNA binding surface [nucleotide binding]; other site 633147004727 anticodon binding site; other site 633147004728 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 633147004729 Predicted methyltransferases [General function prediction only]; Region: COG0313 633147004730 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 633147004731 putative SAM binding site [chemical binding]; other site 633147004732 putative homodimer interface [polypeptide binding]; other site 633147004733 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 633147004734 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147004735 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 633147004736 PSP1 C-terminal conserved region; Region: PSP1; cl00770 633147004737 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 633147004738 DNA polymerase III subunit delta'; Validated; Region: PRK08485 633147004739 thymidylate kinase; Validated; Region: tmk; PRK00698 633147004740 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 633147004741 TMP-binding site; other site 633147004742 ATP-binding site [chemical binding]; other site 633147004743 DNA topoisomerase I; Validated; Region: PRK07219 633147004744 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 633147004745 active site 633147004746 putative interdomain interaction site [polypeptide binding]; other site 633147004747 putative metal-binding site [ion binding]; other site 633147004748 putative nucleotide binding site [chemical binding]; other site 633147004749 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 633147004750 domain I; other site 633147004751 DNA binding groove [nucleotide binding] 633147004752 phosphate binding site [ion binding]; other site 633147004753 domain II; other site 633147004754 domain III; other site 633147004755 nucleotide binding site [chemical binding]; other site 633147004756 catalytic site [active] 633147004757 domain IV; other site 633147004758 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 633147004759 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 633147004760 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 633147004761 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 633147004762 anti sigma factor interaction site; other site 633147004763 regulatory phosphorylation site [posttranslational modification]; other site 633147004764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 633147004765 TPR motif; other site 633147004766 binding surface 633147004767 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 633147004768 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147004769 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147004770 catalytic residue [active] 633147004771 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 633147004772 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 633147004773 DHH family; Region: DHH; pfam01368 633147004774 DHHA2 domain; Region: DHHA2; pfam02833 633147004775 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 633147004776 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 633147004777 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147004778 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147004779 S-ribosylhomocysteinase; Provisional; Region: PRK02260 633147004780 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 633147004781 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 633147004782 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 633147004783 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 633147004784 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 633147004785 active site 633147004786 metal binding site [ion binding]; metal-binding site 633147004787 nudix motif; other site 633147004788 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 633147004789 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 633147004790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 633147004791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 633147004792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 633147004793 dimerization interface [polypeptide binding]; other site 633147004794 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 633147004795 Flavoprotein; Region: Flavoprotein; pfam02441 633147004796 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 633147004797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 633147004798 transmembrane helices; other site 633147004799 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 633147004800 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 633147004801 Mechanosensitive ion channel; Region: MS_channel; pfam00924 633147004802 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 633147004803 Part of AAA domain; Region: AAA_19; pfam13245 633147004804 Family description; Region: UvrD_C_2; pfam13538 633147004805 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 633147004806 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 633147004807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 633147004808 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 633147004809 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 633147004810 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147004811 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 633147004812 Walker A/P-loop; other site 633147004813 ATP binding site [chemical binding]; other site 633147004814 Q-loop/lid; other site 633147004815 ABC transporter signature motif; other site 633147004816 Walker B; other site 633147004817 D-loop; other site 633147004818 H-loop/switch region; other site 633147004819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004820 Walker A/P-loop; other site 633147004821 ATP binding site [chemical binding]; other site 633147004822 Q-loop/lid; other site 633147004823 ABC transporter signature motif; other site 633147004824 Walker B; other site 633147004825 D-loop; other site 633147004826 H-loop/switch region; other site 633147004827 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004828 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004829 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633147004830 Walker A/P-loop; other site 633147004831 ATP binding site [chemical binding]; other site 633147004832 Q-loop/lid; other site 633147004833 ABC transporter signature motif; other site 633147004834 Walker B; other site 633147004835 D-loop; other site 633147004836 H-loop/switch region; other site 633147004837 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147004838 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004840 Walker A/P-loop; other site 633147004841 ATP binding site [chemical binding]; other site 633147004842 Q-loop/lid; other site 633147004843 ABC transporter signature motif; other site 633147004844 Walker B; other site 633147004845 D-loop; other site 633147004846 H-loop/switch region; other site 633147004847 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 633147004848 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 633147004849 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 633147004850 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 633147004851 Walker A/P-loop; other site 633147004852 ATP binding site [chemical binding]; other site 633147004853 Q-loop/lid; other site 633147004854 ABC transporter signature motif; other site 633147004855 Walker B; other site 633147004856 D-loop; other site 633147004857 H-loop/switch region; other site 633147004858 TOBE domain; Region: TOBE_2; pfam08402 633147004859 4-alpha-glucanotransferase; Provisional; Region: PRK14508 633147004860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 633147004861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004862 dimer interface [polypeptide binding]; other site 633147004863 conserved gate region; other site 633147004864 putative PBP binding loops; other site 633147004865 ABC-ATPase subunit interface; other site 633147004866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004867 dimer interface [polypeptide binding]; other site 633147004868 conserved gate region; other site 633147004869 putative PBP binding loops; other site 633147004870 ABC-ATPase subunit interface; other site 633147004871 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 633147004872 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 633147004873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 633147004874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 633147004875 DNA binding site [nucleotide binding] 633147004876 domain linker motif; other site 633147004877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 633147004878 dimerization interface [polypeptide binding]; other site 633147004879 ligand binding site [chemical binding]; other site 633147004880 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 633147004881 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 633147004882 active site 633147004883 catalytic site [active] 633147004884 hybrid cluster protein; Provisional; Region: PRK05290 633147004885 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 633147004886 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 633147004887 ACS interaction site; other site 633147004888 CODH interaction site; other site 633147004889 metal cluster binding site [ion binding]; other site 633147004890 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 633147004891 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 633147004892 Walker A/P-loop; other site 633147004893 ATP binding site [chemical binding]; other site 633147004894 Q-loop/lid; other site 633147004895 ABC transporter signature motif; other site 633147004896 Walker B; other site 633147004897 D-loop; other site 633147004898 H-loop/switch region; other site 633147004899 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 633147004900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004901 dimer interface [polypeptide binding]; other site 633147004902 conserved gate region; other site 633147004903 putative PBP binding loops; other site 633147004904 ABC-ATPase subunit interface; other site 633147004905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 633147004906 dimer interface [polypeptide binding]; other site 633147004907 conserved gate region; other site 633147004908 putative PBP binding loops; other site 633147004909 ABC-ATPase subunit interface; other site 633147004910 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 633147004911 substrate binding pocket [chemical binding]; other site 633147004912 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 633147004913 membrane-bound complex binding site; other site 633147004914 hinge residues; other site 633147004915 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 633147004916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 633147004917 Ligand Binding Site [chemical binding]; other site 633147004918 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 633147004919 EamA-like transporter family; Region: EamA; pfam00892 633147004920 EamA-like transporter family; Region: EamA; pfam00892 633147004921 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 633147004922 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 633147004923 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 633147004924 Peptidase M16C associated; Region: M16C_assoc; pfam08367 633147004925 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 633147004926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147004927 active site 633147004928 motif I; other site 633147004929 motif II; other site 633147004930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 633147004931 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 633147004932 ATP cone domain; Region: ATP-cone; pfam03477 633147004933 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 633147004934 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 633147004935 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 633147004936 FeS/SAM binding site; other site 633147004937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147004938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147004939 dimer interface [polypeptide binding]; other site 633147004940 phosphorylation site [posttranslational modification] 633147004941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147004942 ATP binding site [chemical binding]; other site 633147004943 Mg2+ binding site [ion binding]; other site 633147004944 G-X-G motif; other site 633147004945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147004946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147004947 active site 633147004948 phosphorylation site [posttranslational modification] 633147004949 intermolecular recognition site; other site 633147004950 dimerization interface [polypeptide binding]; other site 633147004951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147004952 DNA binding site [nucleotide binding] 633147004953 Transcription factor homologous to NACalpha-BTF3 [Transcription]; Region: EGD2; COG1308 633147004954 Type III pantothenate kinase; Region: Pan_kinase; cl17198 633147004955 OPT oligopeptide transporter protein; Region: OPT; cl14607 633147004956 OPT oligopeptide transporter protein; Region: OPT; cl14607 633147004957 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 633147004958 FMN binding site [chemical binding]; other site 633147004959 dimer interface [polypeptide binding]; other site 633147004960 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147004961 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147004962 phosphopeptide binding site; other site 633147004963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 633147004964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 633147004965 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 633147004966 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147004967 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 633147004968 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147004969 Walker A/P-loop; other site 633147004970 ATP binding site [chemical binding]; other site 633147004971 Q-loop/lid; other site 633147004972 ABC transporter signature motif; other site 633147004973 Walker B; other site 633147004974 D-loop; other site 633147004975 H-loop/switch region; other site 633147004976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004977 Walker A/P-loop; other site 633147004978 ATP binding site [chemical binding]; other site 633147004979 Q-loop/lid; other site 633147004980 ABC transporter signature motif; other site 633147004981 Walker B; other site 633147004982 D-loop; other site 633147004983 H-loop/switch region; other site 633147004984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147004985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004987 Walker A/P-loop; other site 633147004988 ATP binding site [chemical binding]; other site 633147004989 Q-loop/lid; other site 633147004990 ABC transporter signature motif; other site 633147004991 Walker B; other site 633147004992 D-loop; other site 633147004993 H-loop/switch region; other site 633147004994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147004995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147004996 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147004997 Walker A/P-loop; other site 633147004998 ATP binding site [chemical binding]; other site 633147004999 Q-loop/lid; other site 633147005000 ABC transporter signature motif; other site 633147005001 Walker B; other site 633147005002 D-loop; other site 633147005003 H-loop/switch region; other site 633147005004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 633147005005 Proteins of 100 residues with WXG; Region: WXG100; cl02005 633147005006 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 633147005007 RHS Repeat; Region: RHS_repeat; pfam05593 633147005008 RHS Repeat; Region: RHS_repeat; cl11982 633147005009 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 633147005010 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147005011 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147005012 phosphopeptide binding site; other site 633147005013 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 633147005014 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 633147005015 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 633147005016 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 633147005017 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 633147005018 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 633147005019 Catalytic domain of Protein Kinases; Region: PKc; cd00180 633147005020 active site 633147005021 ATP binding site [chemical binding]; other site 633147005022 substrate binding site [chemical binding]; other site 633147005023 activation loop (A-loop); other site 633147005024 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 633147005025 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 633147005026 tartrate dehydrogenase; Provisional; Region: PRK08194 633147005027 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 633147005028 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 633147005029 substrate binding site [chemical binding]; other site 633147005030 Dehydratase family; Region: ILVD_EDD; cl00340 633147005031 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 633147005032 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 633147005033 substrate binding site [chemical binding]; other site 633147005034 ligand binding site [chemical binding]; other site 633147005035 2-isopropylmalate synthase; Validated; Region: PRK00915 633147005036 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 633147005037 active site 633147005038 catalytic residues [active] 633147005039 metal binding site [ion binding]; metal-binding site 633147005040 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 633147005041 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 633147005042 active site 633147005043 EDD domain protein, DegV family; Region: DegV; TIGR00762 633147005044 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 633147005045 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 633147005046 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 633147005047 putative NADH binding site [chemical binding]; other site 633147005048 putative active site [active] 633147005049 nudix motif; other site 633147005050 putative metal binding site [ion binding]; other site 633147005051 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 633147005052 active site 633147005053 catalytic residues [active] 633147005054 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 633147005055 Beta-lactamase; Region: Beta-lactamase; pfam00144 633147005056 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 633147005057 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 633147005058 ligand binding site [chemical binding]; other site 633147005059 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 633147005060 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 633147005061 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 633147005062 FAD binding domain; Region: FAD_binding_4; pfam01565 633147005063 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 633147005064 Predicted membrane protein [Function unknown]; Region: COG3601 633147005065 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 633147005066 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147005067 Walker A/P-loop; other site 633147005068 ATP binding site [chemical binding]; other site 633147005069 Q-loop/lid; other site 633147005070 ABC transporter signature motif; other site 633147005071 Walker B; other site 633147005072 D-loop; other site 633147005073 H-loop/switch region; other site 633147005074 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633147005075 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147005076 Walker A/P-loop; other site 633147005077 ATP binding site [chemical binding]; other site 633147005078 Q-loop/lid; other site 633147005079 ABC transporter signature motif; other site 633147005080 Walker B; other site 633147005081 D-loop; other site 633147005082 H-loop/switch region; other site 633147005083 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147005084 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 633147005085 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 633147005086 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 633147005087 dimerization interface [polypeptide binding]; other site 633147005088 ATP binding site [chemical binding]; other site 633147005089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 633147005090 dimerization interface [polypeptide binding]; other site 633147005091 ATP binding site [chemical binding]; other site 633147005092 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 633147005093 putative active site [active] 633147005094 catalytic triad [active] 633147005095 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 633147005096 reactive center loop; other site 633147005097 UDP-glucose 4-epimerase; Region: PLN02240 633147005098 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 633147005099 NAD binding site [chemical binding]; other site 633147005100 homodimer interface [polypeptide binding]; other site 633147005101 active site 633147005102 substrate binding site [chemical binding]; other site 633147005103 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 633147005104 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 633147005105 substrate binding pocket [chemical binding]; other site 633147005106 chain length determination region; other site 633147005107 substrate-Mg2+ binding site; other site 633147005108 catalytic residues [active] 633147005109 aspartate-rich region 1; other site 633147005110 active site lid residues [active] 633147005111 aspartate-rich region 2; other site 633147005112 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 633147005113 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 633147005114 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 633147005115 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 633147005116 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 633147005117 Substrate binding site; other site 633147005118 Mg++ binding site; other site 633147005119 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 633147005120 active site 633147005121 substrate binding site [chemical binding]; other site 633147005122 CoA binding site [chemical binding]; other site 633147005123 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 633147005124 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 633147005125 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147005126 active site 633147005127 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 633147005128 putative substrate binding pocket [chemical binding]; other site 633147005129 AC domain interface; other site 633147005130 catalytic triad [active] 633147005131 AB domain interface; other site 633147005132 interchain disulfide; other site 633147005133 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 633147005134 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 633147005135 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 633147005136 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 633147005137 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 633147005138 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 633147005139 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 633147005140 Soluble P-type ATPase [General function prediction only]; Region: COG4087 633147005141 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 633147005142 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 633147005143 putative active site [active] 633147005144 catalytic residue [active] 633147005145 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 633147005146 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 633147005147 FAD binding pocket [chemical binding]; other site 633147005148 FAD binding motif [chemical binding]; other site 633147005149 phosphate binding motif [ion binding]; other site 633147005150 beta-alpha-beta structure motif; other site 633147005151 NAD binding pocket [chemical binding]; other site 633147005152 Iron coordination center [ion binding]; other site 633147005153 putative oxidoreductase; Provisional; Region: PRK12831 633147005154 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 633147005155 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 633147005156 short chain dehydrogenase; Provisional; Region: PRK08226 633147005157 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 633147005158 NAD(P) binding site [chemical binding]; other site 633147005159 active site 633147005160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 633147005161 active site 633147005162 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 633147005163 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 633147005164 active site 633147005165 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 633147005166 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 633147005167 active site 633147005168 dimerization interface 3.5A [polypeptide binding]; other site 633147005169 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 633147005170 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633147005171 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147005172 Walker A/P-loop; other site 633147005173 ATP binding site [chemical binding]; other site 633147005174 Q-loop/lid; other site 633147005175 ABC transporter signature motif; other site 633147005176 Walker B; other site 633147005177 D-loop; other site 633147005178 H-loop/switch region; other site 633147005179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 633147005180 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 633147005181 Walker A/P-loop; other site 633147005182 ATP binding site [chemical binding]; other site 633147005183 Q-loop/lid; other site 633147005184 ABC transporter signature motif; other site 633147005185 Walker B; other site 633147005186 D-loop; other site 633147005187 H-loop/switch region; other site 633147005188 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 633147005189 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 633147005190 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 633147005191 alphaNTD homodimer interface [polypeptide binding]; other site 633147005192 alphaNTD - beta interaction site [polypeptide binding]; other site 633147005193 alphaNTD - beta' interaction site [polypeptide binding]; other site 633147005194 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 633147005195 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 633147005196 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 633147005197 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 633147005198 RNA binding surface [nucleotide binding]; other site 633147005199 30S ribosomal protein S11; Validated; Region: PRK05309 633147005200 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 633147005201 30S ribosomal protein S13; Region: bact_S13; TIGR03631 633147005202 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 633147005203 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 633147005204 rRNA binding site [nucleotide binding]; other site 633147005205 predicted 30S ribosome binding site; other site 633147005206 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 633147005207 active site 633147005208 adenylate kinase; Reviewed; Region: adk; PRK00279 633147005209 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 633147005210 AMP-binding site [chemical binding]; other site 633147005211 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 633147005212 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 633147005213 SecY translocase; Region: SecY; pfam00344 633147005214 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 633147005215 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 633147005216 23S rRNA binding site [nucleotide binding]; other site 633147005217 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 633147005218 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 633147005219 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 633147005220 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 633147005221 23S rRNA interface [nucleotide binding]; other site 633147005222 5S rRNA interface [nucleotide binding]; other site 633147005223 L27 interface [polypeptide binding]; other site 633147005224 L5 interface [polypeptide binding]; other site 633147005225 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 633147005226 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633147005227 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 633147005228 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 633147005229 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 633147005230 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 633147005231 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 633147005232 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 633147005233 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 633147005234 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 633147005235 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 633147005236 RNA binding site [nucleotide binding]; other site 633147005237 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 633147005238 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 633147005239 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 633147005240 putative translocon interaction site; other site 633147005241 23S rRNA interface [nucleotide binding]; other site 633147005242 signal recognition particle (SRP54) interaction site; other site 633147005243 L23 interface [polypeptide binding]; other site 633147005244 trigger factor interaction site; other site 633147005245 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 633147005246 23S rRNA interface [nucleotide binding]; other site 633147005247 5S rRNA interface [nucleotide binding]; other site 633147005248 putative antibiotic binding site [chemical binding]; other site 633147005249 L25 interface [polypeptide binding]; other site 633147005250 L27 interface [polypeptide binding]; other site 633147005251 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 633147005252 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 633147005253 G-X-X-G motif; other site 633147005254 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 633147005255 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 633147005256 putative translocon binding site; other site 633147005257 protein-rRNA interface [nucleotide binding]; other site 633147005258 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 633147005259 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 633147005260 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 633147005261 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 633147005262 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 633147005263 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 633147005264 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 633147005265 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 633147005266 elongation factor G; Reviewed; Region: PRK00007 633147005267 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 633147005268 G1 box; other site 633147005269 putative GEF interaction site [polypeptide binding]; other site 633147005270 GTP/Mg2+ binding site [chemical binding]; other site 633147005271 Switch I region; other site 633147005272 G2 box; other site 633147005273 G3 box; other site 633147005274 Switch II region; other site 633147005275 G4 box; other site 633147005276 G5 box; other site 633147005277 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 633147005278 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 633147005279 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 633147005280 30S ribosomal protein S7; Validated; Region: PRK05302 633147005281 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 633147005282 S17 interaction site [polypeptide binding]; other site 633147005283 S8 interaction site; other site 633147005284 16S rRNA interaction site [nucleotide binding]; other site 633147005285 streptomycin interaction site [chemical binding]; other site 633147005286 23S rRNA interaction site [nucleotide binding]; other site 633147005287 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 633147005288 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147005289 dimerization interface [polypeptide binding]; other site 633147005290 putative DNA binding site [nucleotide binding]; other site 633147005291 putative Zn2+ binding site [ion binding]; other site 633147005292 DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906 633147005293 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 633147005294 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 633147005295 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 633147005296 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 633147005297 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 633147005298 cleft; other site 633147005299 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 633147005300 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 633147005301 DNA binding site [nucleotide binding] 633147005302 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 633147005303 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 633147005304 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 633147005305 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 633147005306 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 633147005307 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 633147005308 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 633147005309 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 633147005310 RPB10 interaction site [polypeptide binding]; other site 633147005311 RPB1 interaction site [polypeptide binding]; other site 633147005312 RPB11 interaction site [polypeptide binding]; other site 633147005313 RPB3 interaction site [polypeptide binding]; other site 633147005314 RPB12 interaction site [polypeptide binding]; other site 633147005315 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 633147005316 peripheral dimer interface [polypeptide binding]; other site 633147005317 core dimer interface [polypeptide binding]; other site 633147005318 L10 interface [polypeptide binding]; other site 633147005319 L11 interface [polypeptide binding]; other site 633147005320 putative EF-Tu interaction site [polypeptide binding]; other site 633147005321 putative EF-G interaction site [polypeptide binding]; other site 633147005322 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 633147005323 23S rRNA interface [nucleotide binding]; other site 633147005324 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 633147005325 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 633147005326 mRNA/rRNA interface [nucleotide binding]; other site 633147005327 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 633147005328 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 633147005329 23S rRNA interface [nucleotide binding]; other site 633147005330 L7/L12 interface [polypeptide binding]; other site 633147005331 putative thiostrepton binding site; other site 633147005332 L25 interface [polypeptide binding]; other site 633147005333 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 633147005334 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 633147005335 putative homodimer interface [polypeptide binding]; other site 633147005336 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 633147005337 heterodimer interface [polypeptide binding]; other site 633147005338 homodimer interface [polypeptide binding]; other site 633147005339 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 633147005340 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 633147005341 elongation factor Tu; Reviewed; Region: PRK00049 633147005342 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 633147005343 G1 box; other site 633147005344 GEF interaction site [polypeptide binding]; other site 633147005345 GTP/Mg2+ binding site [chemical binding]; other site 633147005346 Switch I region; other site 633147005347 G2 box; other site 633147005348 G3 box; other site 633147005349 Switch II region; other site 633147005350 G4 box; other site 633147005351 G5 box; other site 633147005352 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 633147005353 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 633147005354 Antibiotic Binding Site [chemical binding]; other site 633147005355 YacP-like NYN domain; Region: NYN_YacP; pfam05991 633147005356 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 633147005357 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 633147005358 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 633147005359 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 633147005360 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633147005361 active site 633147005362 HIGH motif; other site 633147005363 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 633147005364 KMSKS motif; other site 633147005365 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 633147005366 tRNA binding surface [nucleotide binding]; other site 633147005367 anticodon binding site; other site 633147005368 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 633147005369 homotrimer interaction site [polypeptide binding]; other site 633147005370 zinc binding site [ion binding]; other site 633147005371 CDP-binding sites; other site 633147005372 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 633147005373 substrate binding site; other site 633147005374 dimer interface; other site 633147005375 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 633147005376 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 633147005377 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 633147005378 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 633147005379 Clp amino terminal domain; Region: Clp_N; pfam02861 633147005380 Clp amino terminal domain; Region: Clp_N; pfam02861 633147005381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147005382 Walker A motif; other site 633147005383 ATP binding site [chemical binding]; other site 633147005384 Walker B motif; other site 633147005385 arginine finger; other site 633147005386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147005387 Walker A motif; other site 633147005388 ATP binding site [chemical binding]; other site 633147005389 Walker B motif; other site 633147005390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 633147005391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 633147005392 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 633147005393 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 633147005394 dimer interface [polypeptide binding]; other site 633147005395 putative anticodon binding site; other site 633147005396 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 633147005397 motif 1; other site 633147005398 active site 633147005399 motif 2; other site 633147005400 motif 3; other site 633147005401 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 633147005402 dimer interface [polypeptide binding]; other site 633147005403 putative tRNA-binding site [nucleotide binding]; other site 633147005404 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 633147005405 metal ion-dependent adhesion site (MIDAS); other site 633147005406 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 633147005407 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 633147005408 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 633147005409 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 633147005410 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 633147005411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 633147005412 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 633147005413 histone acetyltransferase, ELP3 family; Region: ELP3; TIGR01211 633147005414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 633147005415 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147005416 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147005417 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 633147005418 Walker A/P-loop; other site 633147005419 ATP binding site [chemical binding]; other site 633147005420 Q-loop/lid; other site 633147005421 ABC transporter signature motif; other site 633147005422 Walker B; other site 633147005423 D-loop; other site 633147005424 H-loop/switch region; other site 633147005425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147005426 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147005427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005428 Walker A/P-loop; other site 633147005429 ATP binding site [chemical binding]; other site 633147005430 Q-loop/lid; other site 633147005431 ABC transporter signature motif; other site 633147005432 Walker B; other site 633147005433 D-loop; other site 633147005434 H-loop/switch region; other site 633147005435 MarR family; Region: MarR_2; pfam12802 633147005436 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 633147005437 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 633147005438 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 633147005439 Flavodoxin domain; Region: Flavodoxin_5; cl17428 633147005440 Uncharacterized conserved protein [Function unknown]; Region: COG0327 633147005441 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 633147005442 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633147005443 active site 633147005444 active pocket/dimerization site; other site 633147005445 phosphorylation site [posttranslational modification] 633147005446 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 633147005447 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 633147005448 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 633147005449 active site 633147005450 phosphorylation site [posttranslational modification] 633147005451 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 633147005452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 633147005453 Walker A motif; other site 633147005454 ATP binding site [chemical binding]; other site 633147005455 Transcriptional antiterminator [Transcription]; Region: COG3933 633147005456 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 633147005457 active pocket/dimerization site; other site 633147005458 active site 633147005459 phosphorylation site [posttranslational modification] 633147005460 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147005461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147005462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005463 Walker A/P-loop; other site 633147005464 ATP binding site [chemical binding]; other site 633147005465 Q-loop/lid; other site 633147005466 ABC transporter signature motif; other site 633147005467 Walker B; other site 633147005468 D-loop; other site 633147005469 H-loop/switch region; other site 633147005470 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 633147005471 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 633147005472 Walker A/P-loop; other site 633147005473 ATP binding site [chemical binding]; other site 633147005474 Q-loop/lid; other site 633147005475 ABC transporter signature motif; other site 633147005476 Walker B; other site 633147005477 D-loop; other site 633147005478 H-loop/switch region; other site 633147005479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 633147005480 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 633147005481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005482 Walker A/P-loop; other site 633147005483 ATP binding site [chemical binding]; other site 633147005484 Q-loop/lid; other site 633147005485 ABC transporter signature motif; other site 633147005486 Walker B; other site 633147005487 D-loop; other site 633147005488 H-loop/switch region; other site 633147005489 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 633147005490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005491 Walker A/P-loop; other site 633147005492 ATP binding site [chemical binding]; other site 633147005493 Q-loop/lid; other site 633147005494 ABC transporter signature motif; other site 633147005495 Walker B; other site 633147005496 D-loop; other site 633147005497 H-loop/switch region; other site 633147005498 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 633147005499 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 633147005500 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 633147005501 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 633147005502 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 633147005503 dimerization interface [polypeptide binding]; other site 633147005504 DPS ferroxidase diiron center [ion binding]; other site 633147005505 ion pore; other site 633147005506 Uncharacterized conserved protein [Function unknown]; Region: COG1479 633147005507 Protein of unknown function DUF262; Region: DUF262; pfam03235 633147005508 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 633147005509 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 633147005510 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 633147005511 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 633147005512 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 633147005513 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 633147005514 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 633147005515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 633147005516 active site 633147005517 DNA binding site [nucleotide binding] 633147005518 Int/Topo IB signature motif; other site 633147005519 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 633147005520 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 633147005521 HsdM N-terminal domain; Region: HsdM_N; pfam12161 633147005522 Methyltransferase domain; Region: Methyltransf_26; pfam13659 633147005523 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 633147005524 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 633147005525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147005526 ATP binding site [chemical binding]; other site 633147005527 putative Mg++ binding site [ion binding]; other site 633147005528 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 633147005529 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 633147005530 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 633147005531 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 633147005532 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 633147005533 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 633147005534 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 633147005535 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 633147005536 active site 633147005537 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 633147005538 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 633147005539 active site 633147005540 trimer interface [polypeptide binding]; other site 633147005541 allosteric site; other site 633147005542 active site lid [active] 633147005543 hexamer (dimer of trimers) interface [polypeptide binding]; other site 633147005544 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 633147005545 active site 633147005546 dimerization interface [polypeptide binding]; other site 633147005547 ribonuclease PH; Reviewed; Region: rph; PRK00173 633147005548 Ribonuclease PH; Region: RNase_PH_bact; cd11362 633147005549 hexamer interface [polypeptide binding]; other site 633147005550 active site 633147005551 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 633147005552 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 633147005553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 633147005554 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 633147005555 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 633147005556 NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179 633147005557 putative active site [active] 633147005558 metal binding site [ion binding]; metal-binding site 633147005559 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 633147005560 active site 633147005561 phosphorylation site [posttranslational modification] 633147005562 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 633147005563 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 633147005564 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 633147005565 active site 633147005566 P-loop; other site 633147005567 phosphorylation site [posttranslational modification] 633147005568 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147005569 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147005570 DNA-binding site [nucleotide binding]; DNA binding site 633147005571 UTRA domain; Region: UTRA; pfam07702 633147005572 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 633147005573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 633147005574 DNA-binding site [nucleotide binding]; DNA binding site 633147005575 UTRA domain; Region: UTRA; pfam07702 633147005576 exopolyphosphatase; Region: exo_poly_only; TIGR03706 633147005577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 633147005578 nucleotide binding site [chemical binding]; other site 633147005579 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 633147005580 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 633147005581 homodimer interface [polypeptide binding]; other site 633147005582 metal binding site [ion binding]; metal-binding site 633147005583 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 633147005584 homodimer interface [polypeptide binding]; other site 633147005585 active site 633147005586 putative chemical substrate binding site [chemical binding]; other site 633147005587 metal binding site [ion binding]; metal-binding site 633147005588 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 633147005589 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 633147005590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 633147005591 ATP binding site [chemical binding]; other site 633147005592 putative Mg++ binding site [ion binding]; other site 633147005593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 633147005594 nucleotide binding region [chemical binding]; other site 633147005595 ATP-binding site [chemical binding]; other site 633147005596 TRCF domain; Region: TRCF; pfam03461 633147005597 putative bifunctional 4-alpha-glucanotransferase/glycogen debranching enzyme; Provisional; Region: PRK14510 633147005598 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 633147005599 active site 633147005600 homodimer interface [polypeptide binding]; other site 633147005601 catalytic site [active] 633147005602 4-alpha-glucanotransferase; Provisional; Region: PRK14508 633147005603 glycogen synthase; Provisional; Region: glgA; PRK00654 633147005604 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 633147005605 ADP-binding pocket [chemical binding]; other site 633147005606 homodimer interface [polypeptide binding]; other site 633147005607 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 633147005608 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 633147005609 ligand binding site; other site 633147005610 oligomer interface; other site 633147005611 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 633147005612 dimer interface [polypeptide binding]; other site 633147005613 N-terminal domain interface [polypeptide binding]; other site 633147005614 sulfate 1 binding site; other site 633147005615 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 633147005616 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 633147005617 ligand binding site; other site 633147005618 oligomer interface; other site 633147005619 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 633147005620 dimer interface [polypeptide binding]; other site 633147005621 N-terminal domain interface [polypeptide binding]; other site 633147005622 sulfate 1 binding site; other site 633147005623 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 633147005624 homodimer interface [polypeptide binding]; other site 633147005625 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 633147005626 active site pocket [active] 633147005627 glycogen branching enzyme; Provisional; Region: PRK12313 633147005628 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 633147005629 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 633147005630 active site 633147005631 catalytic site [active] 633147005632 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 633147005633 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 633147005634 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633147005635 minor groove reading motif; other site 633147005636 helix-hairpin-helix signature motif; other site 633147005637 substrate binding pocket [chemical binding]; other site 633147005638 active site 633147005639 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 633147005640 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 633147005641 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 633147005642 catalytic residue [active] 633147005643 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 633147005644 Rubrerythrin [Energy production and conversion]; Region: COG1592 633147005645 binuclear metal center [ion binding]; other site 633147005646 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 633147005647 iron binding site [ion binding]; other site 633147005648 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 633147005649 endonuclease III; Region: ENDO3c; smart00478 633147005650 minor groove reading motif; other site 633147005651 helix-hairpin-helix signature motif; other site 633147005652 substrate binding pocket [chemical binding]; other site 633147005653 active site 633147005654 Rrf2 family protein; Region: rrf2_super; TIGR00738 633147005655 Transcriptional regulator; Region: Rrf2; pfam02082 633147005656 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 633147005657 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 633147005658 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 633147005659 recombination protein RecR; Reviewed; Region: recR; PRK00076 633147005660 RecR protein; Region: RecR; pfam02132 633147005661 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 633147005662 putative active site [active] 633147005663 putative metal-binding site [ion binding]; other site 633147005664 tetramer interface [polypeptide binding]; other site 633147005665 hypothetical protein; Validated; Region: PRK00153 633147005666 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 633147005667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147005668 Walker A motif; other site 633147005669 ATP binding site [chemical binding]; other site 633147005670 Walker B motif; other site 633147005671 arginine finger; other site 633147005672 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 633147005673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 633147005674 catalytic core [active] 633147005675 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 633147005676 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 633147005677 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 633147005678 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 633147005679 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 633147005680 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 633147005681 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 633147005682 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 633147005683 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 633147005684 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 633147005685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147005686 active site 633147005687 phosphorylation site [posttranslational modification] 633147005688 intermolecular recognition site; other site 633147005689 dimerization interface [polypeptide binding]; other site 633147005690 LytTr DNA-binding domain; Region: LytTR; pfam04397 633147005691 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 633147005692 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 633147005693 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 633147005694 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 633147005695 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 633147005696 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 633147005697 active site 633147005698 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 633147005699 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 633147005700 domain interaction interfaces [polypeptide binding]; other site 633147005701 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 633147005702 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 633147005703 active site 633147005704 dimer interface [polypeptide binding]; other site 633147005705 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 633147005706 dimer interface [polypeptide binding]; other site 633147005707 active site 633147005708 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 633147005709 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 633147005710 catalytic residues [active] 633147005711 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 633147005712 active site 633147005713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 633147005714 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 633147005715 active site 633147005716 metal binding site [ion binding]; metal-binding site 633147005717 homotetramer interface [polypeptide binding]; other site 633147005718 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 633147005719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147005720 active site 633147005721 phosphorylation site [posttranslational modification] 633147005722 intermolecular recognition site; other site 633147005723 dimerization interface [polypeptide binding]; other site 633147005724 LytTr DNA-binding domain; Region: LytTR; smart00850 633147005725 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 633147005726 Histidine kinase; Region: His_kinase; pfam06580 633147005727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147005728 ATP binding site [chemical binding]; other site 633147005729 Mg2+ binding site [ion binding]; other site 633147005730 G-X-G motif; other site 633147005731 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 633147005732 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 633147005733 QueT transporter; Region: QueT; cl01932 633147005734 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633147005735 Uncharacterized conserved protein [Function unknown]; Region: COG1284 633147005736 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 633147005737 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 633147005738 agmatine deiminase; Region: agmatine_aguA; TIGR03380 633147005739 putrescine carbamoyltransferase; Provisional; Region: PRK02255 633147005740 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 633147005741 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 633147005742 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 633147005743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 633147005744 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 633147005745 DNA binding residues [nucleotide binding] 633147005746 dimerization interface [polypeptide binding]; other site 633147005747 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 633147005748 carbamate kinase; Reviewed; Region: PRK12686 633147005749 putative substrate binding site [chemical binding]; other site 633147005750 nucleotide binding site [chemical binding]; other site 633147005751 nucleotide binding site [chemical binding]; other site 633147005752 homodimer interface [polypeptide binding]; other site 633147005753 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 633147005754 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 633147005755 active site 633147005756 HIGH motif; other site 633147005757 nucleotide binding site [chemical binding]; other site 633147005758 active site 633147005759 KMSKS motif; other site 633147005760 seryl-tRNA synthetase; Provisional; Region: PRK05431 633147005761 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 633147005762 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 633147005763 dimer interface [polypeptide binding]; other site 633147005764 active site 633147005765 motif 1; other site 633147005766 motif 2; other site 633147005767 motif 3; other site 633147005768 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 633147005769 Catalytic domain of Protein Kinases; Region: PKc; cd00180 633147005770 active site 633147005771 ATP binding site [chemical binding]; other site 633147005772 substrate binding site [chemical binding]; other site 633147005773 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 633147005774 substrate binding site [chemical binding]; other site 633147005775 activation loop (A-loop); other site 633147005776 activation loop (A-loop); other site 633147005777 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 633147005778 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147005779 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147005780 phosphopeptide binding site; other site 633147005781 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 633147005782 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 633147005783 phosphopeptide binding site; other site 633147005784 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 633147005785 active site 633147005786 BofC C-terminal domain; Region: BofC_C; pfam08955 633147005787 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 633147005788 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 633147005789 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 633147005790 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 633147005791 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 633147005792 Catalytic domain of Protein Kinases; Region: PKc; cd00180 633147005793 active site 633147005794 ATP binding site [chemical binding]; other site 633147005795 substrate binding site [chemical binding]; other site 633147005796 activation loop (A-loop); other site 633147005797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 633147005798 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147005799 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147005800 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 633147005801 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 633147005802 3-ketoacyl-CoA synthase; Region: PLN02932 633147005803 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 633147005804 active site 633147005805 ATP binding site [chemical binding]; other site 633147005806 substrate binding site [chemical binding]; other site 633147005807 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 633147005808 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633147005809 dimerization interface [polypeptide binding]; other site 633147005810 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147005811 dimer interface [polypeptide binding]; other site 633147005812 phosphorylation site [posttranslational modification] 633147005813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147005814 ATP binding site [chemical binding]; other site 633147005815 Mg2+ binding site [ion binding]; other site 633147005816 G-X-G motif; other site 633147005817 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147005818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147005819 active site 633147005820 phosphorylation site [posttranslational modification] 633147005821 intermolecular recognition site; other site 633147005822 dimerization interface [polypeptide binding]; other site 633147005823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147005824 DNA binding site [nucleotide binding] 633147005825 adenylosuccinate lyase; Provisional; Region: PRK07492 633147005826 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 633147005827 tetramer interface [polypeptide binding]; other site 633147005828 active site 633147005829 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 633147005830 argininosuccinate lyase; Provisional; Region: PRK00855 633147005831 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 633147005832 active sites [active] 633147005833 tetramer interface [polypeptide binding]; other site 633147005834 argininosuccinate synthase; Provisional; Region: PRK13820 633147005835 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 633147005836 ANP binding site [chemical binding]; other site 633147005837 Substrate Binding Site II [chemical binding]; other site 633147005838 Substrate Binding Site I [chemical binding]; other site 633147005839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147005840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 633147005841 dimerization interface [polypeptide binding]; other site 633147005842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 633147005843 dimer interface [polypeptide binding]; other site 633147005844 phosphorylation site [posttranslational modification] 633147005845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147005846 ATP binding site [chemical binding]; other site 633147005847 Mg2+ binding site [ion binding]; other site 633147005848 G-X-G motif; other site 633147005849 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 633147005850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 633147005851 active site 633147005852 phosphorylation site [posttranslational modification] 633147005853 intermolecular recognition site; other site 633147005854 dimerization interface [polypeptide binding]; other site 633147005855 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 633147005856 DNA binding site [nucleotide binding] 633147005857 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 633147005858 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 633147005859 catalytic residues [active] 633147005860 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633147005861 4Fe-4S binding domain; Region: Fer4_5; pfam12801 633147005862 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 633147005863 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 633147005864 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 633147005865 Bifunctional nuclease; Region: DNase-RNase; pfam02577 633147005866 DNA gyrase subunit A; Validated; Region: PRK05560 633147005867 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 633147005868 CAP-like domain; other site 633147005869 active site 633147005870 primary dimer interface [polypeptide binding]; other site 633147005871 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005872 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005873 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 633147005877 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 633147005878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147005879 ATP binding site [chemical binding]; other site 633147005880 Mg2+ binding site [ion binding]; other site 633147005881 G-X-G motif; other site 633147005882 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 633147005883 anchoring element; other site 633147005884 dimer interface [polypeptide binding]; other site 633147005885 ATP binding site [chemical binding]; other site 633147005886 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 633147005887 active site 633147005888 putative metal-binding site [ion binding]; other site 633147005889 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 633147005890 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 633147005891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005892 Walker A/P-loop; other site 633147005893 ATP binding site [chemical binding]; other site 633147005894 Q-loop/lid; other site 633147005895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 633147005896 ABC transporter signature motif; other site 633147005897 Walker B; other site 633147005898 D-loop; other site 633147005899 H-loop/switch region; other site 633147005900 DNA polymerase III subunit beta; Validated; Region: PRK05643 633147005901 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 633147005902 putative DNA binding surface [nucleotide binding]; other site 633147005903 dimer interface [polypeptide binding]; other site 633147005904 beta-clamp/clamp loader binding surface; other site 633147005905 beta-clamp/translesion DNA polymerase binding surface; other site 633147005906 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 633147005907 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 633147005908 Walker A motif; other site 633147005909 ATP binding site [chemical binding]; other site 633147005910 Walker B motif; other site 633147005911 arginine finger; other site 633147005912 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 633147005913 DnaA box-binding interface [nucleotide binding]; other site 633147005914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 633147005915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 633147005916 ATP binding site [chemical binding]; other site 633147005917 Mg2+ binding site [ion binding]; other site 633147005918 G-X-G motif; other site 633147005919 Transcriptional regulators [Transcription]; Region: MarR; COG1846 633147005920 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 633147005921 dimerization interface [polypeptide binding]; other site 633147005922 putative Zn2+ binding site [ion binding]; other site 633147005923 putative DNA binding site [nucleotide binding]; other site 633147005924 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 633147005925 Ribonuclease P; Region: Ribonuclease_P; pfam00825 633147005926 Haemolytic domain; Region: Haemolytic; pfam01809 633147005927 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 633147005928 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 633147005929 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 633147005930 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 633147005931 G-X-X-G motif; other site 633147005932 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 633147005933 RxxxH motif; other site 633147005934 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 633147005935 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726